BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0599.0051.p (336 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3K8L8.1 B3K8L8_9BACI Cytidyltransferase-related domain protein 591 e-167 B8FBW9.1 B8FBW9_DESAA Cytidyltransferase-related domain protein 363 9e-99 A7BW96.1 A7BW96_9GAMM Transcriptional regulator nadR 357 1e-96 A9AV85.1 A9AV85_HERA2 ATPase/kinase involved in NAD metabolism 345 5e-93 B1DD54.1 B1DD54_9BACL Cytidyltransferase-related domain protein 344 8e-93 >B3K8L8.1 B3K8L8_9BACI Cytidyltransferase-related domain protein Length = 336 Score = 591 bits (1524), Expect = e-167, Method: Compositional matrix adjust. Identities = 285/335 (85%), Positives = 300/335 (89%) Query: 1 MKTLGLTLGKFAPLHKGHQFMIETALQEVDELXXXXXXXXXXXXPLHIRANWIRKLYPAV 60 MKTLGLTLGKFAPLHKGHQFMIETALQEVDEL PLHIRANWIR+LYPAV Sbjct: 1 MKTLGLTLGKFAPLHKGHQFMIETALQEVDELIVVIYETPVTPIPLHIRANWIRRLYPAV 60 Query: 61 RVIEAWDGPDGYSDDREHEIREEQYILGLLNGEQVTHFYSSEFYGEHMSIALGXXXXXXX 120 RVIEAWDGPDGYSDDREHE+REEQYILGLLNGEQVTHFYSSEFYG HMS+ALG Sbjct: 61 RVIEAWDGPDGYSDDREHEVREEQYILGLLNGEQVTHFYSSEFYGRHMSLALGSVDRRVD 120 Query: 121 XXXXXXXXSATMVRSDPYKYRAYVSDIVYRDLITKVVFVGAMSTGKSTITEALAQRYHTT 180 SATM+RSDPYKYR ++SDIVYRDLITKVVFVGAMSTGKSTITEALA+RY+TT Sbjct: 121 EARKRVPISATMIRSDPYKYREFISDIVYRDLITKVVFVGAMSTGKSTITEALARRYNTT 180 Query: 181 YAGEYGRDYWTEHQVDRRIGLKAFDEIAVGHIEREEQALLQANKYLFVDTNAITTYMFAL 240 YA EYGRDYWTEHQVDRRIGL+AFDEIAVGHIEREEQALL AN++LFVDTNAITTYMFAL Sbjct: 181 YASEYGRDYWTEHQVDRRIGLEAFDEIAVGHIEREEQALLAANRFLFVDTNAITTYMFAL 240 Query: 241 DYHGRAPERLTRIALENAQRYDLFFLCDDDIPYEDTWDRSGNQKRHIFHKQIIADLKERR 300 DYHGRAPE LTRIALENAQRYDLFFLCDDDIPY+DTWDRSG+QKRH+FHKQIIADLKERR Sbjct: 241 DYHGRAPELLTRIALENAQRYDLFFLCDDDIPYDDTWDRSGDQKRHVFHKQIIADLKERR 300 Query: 301 IPYITLRGSLEERMCKVDEVLAKFKPYSNYFGELG 335 IPYITLRGSLEERM KVDEVLAKF+PY NYFGEL Sbjct: 301 IPYITLRGSLEERMRKVDEVLAKFEPYRNYFGELN 335 >B8FBW9.1 B8FBW9_DESAA Cytidyltransferase-related domain protein Length = 342 Score = 363 bits (933), Expect = 9e-99, Method: Compositional matrix adjust. Identities = 176/329 (53%), Positives = 220/329 (66%) Query: 1 MKTLGLTLGKFAPLHKGHQFMIETALQEVDELXXXXXXXXXXXXPLHIRANWIRKLYPAV 60 MK GLTLGKFAP HKGHQF+IETA +EVDEL PL +RANWIRKLYP V Sbjct: 1 MKKTGLTLGKFAPFHKGHQFLIETAFREVDELMILVYETGLMDAPLQVRANWIRKLYPQV 60 Query: 61 RVIEAWDGPDGYSDDREHEIREEQYILGLLNGEQVTHFYSSEFYGEHMSIALGXXXXXXX 120 RVIEAW GP GY + E + YIL ++ E++THF+S EFYGEH+S ALG Sbjct: 61 RVIEAWGGPPGYGNSPEIVKEQNDYILSVIGDEKITHFFSGEFYGEHVSKALGANDRRVD 120 Query: 121 XXXXXXXXSATMVRSDPYKYRAYVSDIVYRDLITKVVFVGAMSTGKSTITEALAQRYHTT 180 S T +R D + R +V +VYRDL+T V F+GA STGK+T+ +ALA++Y T Sbjct: 121 PDRRHLPVSGTQIRQDLFANRKFVDPLVYRDLVTWVCFMGAPSTGKTTLVQALAEKYQTV 180 Query: 181 YAGEYGRDYWTEHQVDRRIGLKAFDEIAVGHIEREEQALLQANKYLFVDTNAITTYMFAL 240 + EYG +YW E+ VDRRI L F+EI + H+ RE+ + AN+YLF DT ITTY++A Sbjct: 181 FMTEYGGEYWRENHVDRRITLDQFEEIPLEHMRREDVLVQDANQYLFCDTCPITTYVYAK 240 Query: 241 DYHGRAPERLTRIALENAQRYDLFFLCDDDIPYEDTWDRSGNQKRHIFHKQIIADLKERR 300 DYHG A L + A ++ RYDLFFLCD DIPY DTWDRSG+ KR F QI DL ERR Sbjct: 241 DYHGEAGPVLEKAARDSQSRYDLFFLCDADIPYADTWDRSGDVKRQWFQNQIKGDLAERR 300 Query: 301 IPYITLRGSLEERMCKVDEVLAKFKPYSN 329 IPY LRG +EER+ +V+ VL++FK + N Sbjct: 301 IPYFVLRGGVEERIAQVEHVLSRFKKFGN 329 >A7BW96.1 A7BW96_9GAMM Transcriptional regulator nadR Length = 363 Score = 357 bits (915), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 171/332 (51%), Positives = 222/332 (66%), Gaps = 1/332 (0%) Query: 2 KTLGLTLGKFAPLHKGHQFMIETALQEVDELXXXX-XXXXXXXXPLHIRANWIRKLYPAV 60 KT GLTLGKFAPLHKGHQ +IETAL E+DE+ PL++R NW+RKLYP + Sbjct: 16 KTHGLTLGKFAPLHKGHQLVIETALAEMDEVTVIIYDAPETTRIPLNVRTNWLRKLYPLI 75 Query: 61 RVIEAWDGPDGYSDDREHEIREEQYILGLLNGEQVTHFYSSEFYGEHMSIALGXXXXXXX 120 ++IEAWDGP + E + + E YI+ LN +THFYSSEFYGEH+S+AL Sbjct: 76 KIIEAWDGPTEVGNTPEIKRKHENYIINELNISGITHFYSSEFYGEHISVALSAINRLVN 135 Query: 121 XXXXXXXXSATMVRSDPYKYRAYVSDIVYRDLITKVVFVGAMSTGKSTITEALAQRYHTT 180 S T +R +P+ R Y+ +VY+DLIT VVF+GA STGK+TIT +AQ Y T Sbjct: 136 PSRQIIPISGTKIRENPFVCREYIPPLVYKDLITNVVFLGAPSTGKTTITRRMAQEYDTV 195 Query: 181 YAGEYGRDYWTEHQVDRRIGLKAFDEIAVGHIEREEQALLQANKYLFVDTNAITTYMFAL 240 + EYGR+YW ++QV+RR+ L+ EIA GH+EREE+ + QAN+YLF DTNA+TT+MF+ Sbjct: 196 WMPEYGREYWEKNQVERRLSLEQLVEIAEGHLEREEKLIYQANQYLFTDTNALTTFMFSQ 255 Query: 241 DYHGRAPERLTRIALENAQRYDLFFLCDDDIPYEDTWDRSGNQKRHIFHKQIIADLKERR 300 YH +L + + RYDL FLCD DIPY DTWDRSG+ R F KQII +L R+ Sbjct: 256 YYHQTVASKLIELVNLVSSRYDLVFLCDTDIPYHDTWDRSGDVNRKTFQKQIIEELLARK 315 Query: 301 IPYITLRGSLEERMCKVDEVLAKFKPYSNYFG 332 IP+I L G+LE R+ KV +L+KF+ Y N G Sbjct: 316 IPFIVLNGNLETRVTKVKTILSKFQKYQNTNG 347 >A9AV85.1 A9AV85_HERA2 ATPase/kinase involved in NAD metabolism Length = 334 Score = 345 bits (884), Expect = 5e-93, Method: Compositional matrix adjust. Identities = 173/329 (52%), Positives = 221/329 (67%), Gaps = 1/329 (0%) Query: 5 GLTLGKFAPLHKGHQFMIETALQEVDELXXXX-XXXXXXXXPLHIRANWIRKLYPAVRVI 63 GLTLGKFAPLHKGHQ MIETAL EV EL PL +R+ W+R+LYP +VI Sbjct: 3 GLTLGKFAPLHKGHQLMIETALSEVAELQIIIYDSPEQTSVPLPVRSAWLRELYPQAQVI 62 Query: 64 EAWDGPDGYSDDREHEIREEQYILGLLNGEQVTHFYSSEFYGEHMSIALGXXXXXXXXXX 123 EAWDGP + RE + E Y++ L ++HFYSSEFYGEHMS ALG Sbjct: 63 EAWDGPSVIGNTREIQQLHEDYVIQQLGISNISHFYSSEFYGEHMSQALGAINRQVDPPR 122 Query: 124 XXXXXSATMVRSDPYKYRAYVSDIVYRDLITKVVFVGAMSTGKSTITEALAQRYHTTYAG 183 SAT +RSDPY+YR ++ VYRDLI K+V +GA STGK+T+T LA+ ++T + Sbjct: 123 NQVPISATQIRSDPYRYREFLHPRVYRDLIMKIVLLGAPSTGKTTLTATLAETFNTQWMP 182 Query: 184 EYGRDYWTEHQVDRRIGLKAFDEIAVGHIEREEQALLQANKYLFVDTNAITTYMFALDYH 243 EYGR+YW +HQ +RR+ + EIA GH EREEQ LL++N+YLFVDTNA+TTY FAL YH Sbjct: 183 EYGREYWEQHQSNRRLTPQQLVEIAEGHREREEQRLLESNRYLFVDTNALTTYHFALSYH 242 Query: 244 GRAPERLTRIALENAQRYDLFFLCDDDIPYEDTWDRSGNQKRHIFHKQIIADLKERRIPY 303 GRA RL ++A + QRYDL +CD DIPY+DTWDRSG +R IF KQ+ A L++RR PY Sbjct: 243 GRAEPRLAQLADQAQQRYDLVLVCDSDIPYDDTWDRSGEVQRTIFQKQLFAQLQQRRQPY 302 Query: 304 ITLRGSLEERMCKVDEVLAKFKPYSNYFG 332 + G LE+R+ +V +L + + Y N Sbjct: 303 YLISGPLEQRIAQVQSLLQRHQLYHNLLA 331 >B1DD54.1 B1DD54_9BACL Cytidyltransferase-related domain protein Length = 341 Score = 344 bits (882), Expect = 8e-93, Method: Compositional matrix adjust. Identities = 182/332 (54%), Positives = 224/332 (67%), Gaps = 1/332 (0%) Query: 1 MKTLGLTLGKFAPLHKGHQFMIETALQEVDELXXXX-XXXXXXXXPLHIRANWIRKLYPA 59 +K +GLTLGKFAP H+GHQ ++ETAL+EVD L PL +RA WIRKLYP Sbjct: 3 VKKVGLTLGKFAPFHRGHQHVVETALREVDHLIVVIYDSPEVTPVPLSVRARWIRKLYPT 62 Query: 60 VRVIEAWDGPDGYSDDREHEIREEQYILGLLNGEQVTHFYSSEFYGEHMSIALGXXXXXX 119 V V+EAWDGP D E + +E YILGLL G +VTHFYSSEFYGEHMS ALG Sbjct: 63 VEVLEAWDGPSDSGDTPEVKRIQENYILGLLGGRKVTHFYSSEFYGEHMSEALGAVNRQV 122 Query: 120 XXXXXXXXXSATMVRSDPYKYRAYVSDIVYRDLITKVVFVGAMSTGKSTITEALAQRYHT 179 S T VR ++ ++ V VYRDLIT VF+GA STGK+T+ LA T Sbjct: 123 DPLRETFPVSGTKVREGLFENKSLVEPAVYRDLITNAVFLGAPSTGKTTLASRLAVELQT 182 Query: 180 TYAGEYGRDYWTEHQVDRRIGLKAFDEIAVGHIEREEQALLQANKYLFVDTNAITTYMFA 239 + EYGR+YW EHQ++RR+ L+ EIA GH+EREE+ LL+A LFVDTNAITTYMF+ Sbjct: 183 VWMPEYGREYWEEHQIERRLTLEQLVEIAEGHLEREERLLLEARDALFVDTNAITTYMFS 242 Query: 240 LDYHGRAPERLTRIALENAQRYDLFFLCDDDIPYEDTWDRSGNQKRHIFHKQIIADLKER 299 L YHG A +L +A+ RYDL FLC+DDIPY+DT DRSG R IF KQI+ADL ER Sbjct: 243 LYYHGEAHPKLKEMAVHCVSRYDLVFLCEDDIPYDDTPDRSGEVNRSIFQKQIVADLIER 302 Query: 300 RIPYITLRGSLEERMCKVDEVLAKFKPYSNYF 331 +IP+I LRGSLEER+ +V VL +++ Y N + Sbjct: 303 KIPFIPLRGSLEERVQQVKAVLGRYEKYRNPY 334 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.322 0.138 0.417 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 1,865,276,285 Number of extensions: 70731276 Number of successful extensions: 203670 Number of sequences better than 1.0e-05: 250 Number of HSP's gapped: 203395 Number of HSP's successfully gapped: 250 Length of query: 336 Length of database: 3,060,696,203 Length adjustment: 136 Effective length of query: 200 Effective length of database: 1,779,438,163 Effective search space: 355887632600 Effective search space used: 355887632600 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 131 (55.1 bits)