BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0591.0011.p (522 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KEX4.1 B3KEX4_9BACI Histidine kinase internal region 563 e-158 B1D9Q3.1 B1D9Q3_9BACL Integral membrane sensor signal transducti... 334 1e-89 B1D916.1 B1D916_9BACL Integral membrane sensor signal transducti... 298 8e-79 B1DFU1.1 B1DFU1_9BACL Integral membrane sensor signal transducti... 281 8e-74 C4ZHY0.1 C4ZHY0_9FIRM Two-component sensor histidine kinase 186 4e-45 >B3KEX4.1 B3KEX4_9BACI Histidine kinase internal region Length = 623 Score = 563 bits (1450), Expect = e-158, Method: Compositional matrix adjust. Identities = 279/510 (54%), Positives = 376/510 (73%), Gaps = 10/510 (1%) Query: 1 LSLERTISNLNHVSQQLALQGSIGKKVDLLLSSDKQFERAVLTEEINTEINLISFTNPTI 60 LSLE T+ NLNHVSQQL +G++G++++ L + + ++R+ LT+EI ++NLI+FTNP + Sbjct: 106 LSLENTLDNLNHVSQQLTFKGNVGRQLEKFLMAKQPYDRSYLTDEIKNQLNLITFTNPNV 165 Query: 61 GLMMYYSKVKGTYMFNSTIVKEDYEITGLPLLAEYFRISYFGPHISNERYNDEYVISALR 120 GL +YY + T +F +T +K+ ++I GLP++A Y+ I+YFGPHIS +R+N++YV+SALR Sbjct: 166 GLTLYYLRDDQTTLFENTGMKQPFDIDGLPIIAAYYGITYFGPHISKDRFNNQYVLSALR 225 Query: 121 KVDLPGDPDDMYVYVESGFKMTPSIFE-DNQEDASYYLILDNDKRIAYSDVPEDFAMDDY 179 KVDLP +D YVY+ESGFK+T SI + D + +LILDN+ RI+YS++ + F + Sbjct: 226 KVDLP-QREDAYVYIESGFKLTQSILDLDEVSKHANHLILDNNGRISYSELQDIFPENSI 284 Query: 180 FADS-GSSGDAGLQNGYYWFESTSNQGWSVISLIPVNEYNQQKNRWVIQMIYXXXXXXXX 238 F+D+ S G+ + YYW+ SNQGWSV+SLI ++YN++KNRW++QM+ Sbjct: 285 FSDALAPSLVTGITSDYYWYRQVSNQGWSVVSLIAKSDYNREKNRWMMQMLGLALLFAVV 344 Query: 239 XXXIAWFLWKMVYVPLQQFNHQIKSIAQRN-TAVTEVTRIXXXXXPEFDFLLKQLQNMKN 297 I W LWKMVY PL +FN +IKSIA N A +RI PEF+ +L Q Q+MK Sbjct: 345 SLTIGWLLWKMVYRPLSRFNKEIKSIAGSNFNAAATQSRI-----PEFEMVLNQFQHMKV 399 Query: 298 QIAELIQEVEVKEKGRADLEVEKLLYQINPHFLMNTLDTVHWLAVMNGQKDIDKLVVSLN 357 QI +L EV+ KEK RADLE+EKL YQINPHFLMNTLDT HWLAVMNGQ++ID+LV SLN Sbjct: 400 QITQLYSEVKAKEKRRADLEIEKLQYQINPHFLMNTLDTAHWLAVMNGQEEIDRLVTSLN 459 Query: 358 KLLYYNLGKRGLVSTIREEIDSIRQYLTLQQVRYDFGFDVRIHVDDDVLELPIPRFILQP 417 KLLYYNL K V+TIR+EIDS++QYL LQQ+RY+F FDV IHVDD +LE+ +PRFILQP Sbjct: 460 KLLYYNLRKGNSVATIRDEIDSLKQYLILQQIRYNFQFDVNIHVDDALLEVTVPRFILQP 519 Query: 418 VLENSLYHGLHDEGYIQVEVGKEEGQIIISVYDNGAGISAEEIAKLLHQQQVEQQKAGMG 477 ++ENSLYHGL D G I+V V K + ++ I + DNG GIS E+I LL Q+Q E+ + GMG Sbjct: 520 LVENSLYHGLDDNGRIEVVVRKND-RLEIEIRDNGGGISEEKIEALLEQEQTERHRVGMG 578 Query: 478 IGMSYVKRMIENQYGGLASLEIHSELGQGT 507 IG++YVKRM+E Y G ASL + SELG+GT Sbjct: 579 IGLNYVKRMLEFHYEGKASLTVTSELGKGT 608 >B1D9Q3.1 B1D9Q3_9BACL Integral membrane sensor signal transduction histidine kinase Length = 580 Score = 334 bits (857), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 188/521 (36%), Positives = 301/521 (57%), Gaps = 17/521 (3%) Query: 2 SLERTISNLNHVSQQLALQGSIGKKVDLLLSSDKQFERAVLTEEINTEINLISFTNPTIG 61 SLE T+ NL VSQQ++ QG +G+ ++ L +S+ +E++ L I + +++ +NPTIG Sbjct: 67 SLEETLENLYDVSQQMSYQGFVGRDMEALQTSEDNYEKSQLVVNIQRNMGILNASNPTIG 126 Query: 62 LMMYYSKVKGTYMFNSTIVKEDY-EITGLPLLAEYFRISYFGPHISNERYNDEYVISALR 120 L+ YY G +N+ I ++ + + LP L+ + + GPH++ +YND V S +R Sbjct: 127 LVFYYDTTTGEIQYNNYITRDLHPDFDSLPKLSVHSDHVFNGPHLTLYKYNDIPVFSIVR 186 Query: 121 KVDLPGDPDD-MYVYVESGFKMTPSIFEDNQEDASY-YLILDNDKRIAYSDVPEDFAMDD 178 V DP + + VY E+ + +I Q +L++D D + +SD PE Sbjct: 187 SVGGITDPGNPLLVYAETNVSVIKNILNKEQYGMKVSHLLMDKDGTVLFSDKPE------ 240 Query: 179 YFADSGSSGDAGLQNGYYWFESTSNQGWSVISLIPVNEYNQQKNRWVIQMIYXXXXXXXX 238 GS+ D G YY+ E T +QGW + + EY ++ W ++ + Sbjct: 241 -LTPIGSTYDPGKLKRYYFHEVTGSQGWRLGVFVEKGEYQKEIRDWFVKYAFIVVLGLLI 299 Query: 239 XXXIAWFLWKMVYVPLQQFNHQIKS-IAQRNTAVTEVTRIXXXXXPEFDFLLKQLQNMKN 297 A+ WK+V PL + I + I+Q A ++T + EFDFL++ +M+ Sbjct: 300 SIWSAFRTWKVVISPLHRIRKGISAVISQEPNANFQMTGLR-----EFDFLIQNFNDMQF 354 Query: 298 QIAELIQEVEVKEKGRADLEVEKLLYQINPHFLMNTLDTVHWLAVMNGQKDIDKLVVSLN 357 +I +LI EV + + ++E+EKL+ QINPHFL NTL+T WLA + GQ +ID+ + Sbjct: 355 RIQKLIMEVAKEASEKQEIEMEKLMAQINPHFLYNTLNTAQWLARLKGQHEIDRFLSLFT 414 Query: 358 KLLYYNLGKRGLVSTIREEIDSIRQYLTLQQVRYDFGFDVRIHVDDDVLELPIPRFILQP 417 K+L YNL K G + T+++EI+S+ Y+ LQ++RYDF FDVR + + L P+PRFILQP Sbjct: 415 KVLKYNLAKDGAIVTLKDEIESLNDYVELQKIRYDFEFDVRYSIPEPFLATPLPRFILQP 474 Query: 418 VLENSLYHGLHDE-GYIQVEVGKEEGQIIISVYDNGAGISAEEIAKLLHQQQVEQQKAGM 476 ++EN+LYHG+ DE G I+V + EG +++ V DNG GIS E+I +LL + +G+ Sbjct: 475 IVENALYHGMMDEKGIIEVTAEEREGMLVLMVKDNGNGISPEKIKELLESDTRKNNISGL 534 Query: 477 GIGMSYVKRMIENQYGGLASLEIHSELGQGTTVFLKLPSME 517 GIG++YV R + + GG + L I S++G+GTTV + +P E Sbjct: 535 GIGLNYVVRTLSSFTGGASQLRIDSQIGEGTTVSIHMPMHE 575 >B1D916.1 B1D916_9BACL Integral membrane sensor signal transduction histidine kinase Length = 592 Score = 298 bits (764), Expect = 8e-79, Method: Compositional matrix adjust. Identities = 181/515 (35%), Positives = 284/515 (55%), Gaps = 16/515 (3%) Query: 8 SNLNHVSQQLALQGSIGKKVDLLLSSDKQFERAVLTEEINTEINLISFTNPTIGLMMYYS 67 +NL V+QQ+ +G++G ++ +S+ + + +L+ +I+ I LI+F+NP + L+MYY+ Sbjct: 82 NNLLQVTQQMTPEGTVGHLMETYVSTADIYSQRLLSRDISYNIGLITFSNPAMQLVMYYN 141 Query: 68 KVKGTYMFNSTIVKEDYEITGLPLLAEYFRISYFGPHISNERYNDEYVISALRKVDLPGD 127 + G + V+ D+++ LP +A + Y PH S R++D+ V+S R+V D Sbjct: 142 EANGQAALTNLPVRADFKLESLPDVAGMGELRYQSPHKSLCRFSDDLVVSVTREVTF-SD 200 Query: 128 PDDMYVYVESGFKMTPSIFEDNQED--ASYYLIL-DNDKRIAYSDVPEDFAMDDYFADSG 184 + VYVE+ + P+ E Y L+ D + + YS F + G Sbjct: 201 GTKLVVYVEAKTDI-PTDMSSVTESLKMPYSLVFTDPEGYVTYSSNEAAFKAGQHLELKG 259 Query: 185 SSGDAGLQNGYYWFESTSNQGWSVISLIPVNEYNQQKNRWVIQMIYXXXXXXXXXXXIAW 244 SG + Y W T + G+ + L+PV+ YN + W M + + Sbjct: 260 QSGTT---DEYVWNRMTGDYGYDITMLLPVSYYNHELYTWKNHMYWILAIALLMMFMLTL 316 Query: 245 FLWKMVYVPLQQFNHQIKSIAQRNTAVTEVTRIXXXXXPEFDFLLKQLQNMKNQIAELIQ 304 L +++ P + ++++ + T+ EFD + Q MK QI +LI Sbjct: 317 VLRRLINRPFRLIEKEMRTFGKGYMGTTQ----YHTGIDEFDRIFDQFNIMKRQIQKLII 372 Query: 305 EVEVKEKGRADLEVEKLLYQINPHFLMNTLDTVHWLAVMNGQKDIDKLVVSLNKLLYYNL 364 +VE KEK R LE+EKL YQINPHFLMNTL++V WLAVM+ Q++I+K + SL LL YNL Sbjct: 373 DVEQKEKRRHQLEIEKLAYQINPHFLMNTLNSVRWLAVMHKQEEIEKFISSLIILLNYNL 432 Query: 365 GKRGLVSTIREEIDSIRQYLTLQQVRYDFGFDVRIHVDDDVLELPIPRFILQPVLENSLY 424 GK +T R EI +R YL LQQ+R+DF + I + L+ P+ RFILQP++EN++ Sbjct: 433 GKSEEKATFRSEIQVMRTYLELQQMRHDFEVKLDI-AEGTYLDSPVARFILQPIVENAVC 491 Query: 425 HGLHDEGYIQVEVGKEEG--QIIISVYDNGAGISAEEIAKLLHQQQVEQQKAGMGIGMSY 482 HGL D G +++ V +E + I++ D+G G+S E +A LL + +QQ+ G GIG+ Y Sbjct: 492 HGLDDNGMLEISVVPDEAAQMVRITIRDDGKGLSQETLA-LLQRDTPDQQQTGWGIGLRY 550 Query: 483 VKRMIENQYGGLASLEIHSELGQGTTVFLKLPSME 517 V+ M+E+ YG A + I S QGTTV L LP +E Sbjct: 551 VRSMLESSYGHKARMGIDSTPNQGTTVTLTLPFLE 585 >B1DFU1.1 B1DFU1_9BACL Integral membrane sensor signal transduction histidine kinase Length = 582 Score = 281 bits (720), Expect = 8e-74, Method: Compositional matrix adjust. Identities = 171/522 (32%), Positives = 286/522 (54%), Gaps = 13/522 (2%) Query: 2 SLERTISNLNHVSQQLALQGSIGKKVDLLLSSD-KQFERAVLTEEINTEINLISFTNPTI 60 S++ ++ NL + S+QL L G IGK+++ ++ ++ + +I + + LIS+ N + Sbjct: 63 SMQSSLDNLGYASRQLTLDGDIGKRLEQYMNPTIPNNLKSEIQSDIESRLTLISYANQGL 122 Query: 61 GLMMYYSKVKGTYMFNSTIVKEDYEITGLPLLAEYFRISYFGPHISNERYNDEYVISALR 120 G M Y+ + +F + ++K++ + P L Y GPH S Y+D V S ++ Sbjct: 123 GPMYYFIPEQQMNLFQTMLLKKNIDPMEYPTLFTDPLTLYQGPHPSIYLYSDNIVFSIVQ 182 Query: 121 KVDLPGDPDDMYVYVESGFKMTPSIFEDNQEDASY-YLILDNDKRIAYSDVPEDFAMDDY 179 ++ + YVY+E+ FK+ +F + + YLILD+ + YSD+ + + ++ Sbjct: 183 EMTGNKNLPKTYVYIETNFKVFQDLFPKDAFGFNVNYLILDSSNTVLYSDLTDSYPINSE 242 Query: 180 FADSGSSGDAGLQNGYYWFESTSNQGWSVISLIPVNEYNQQKNRWVIQMIYXXXXXXXXX 239 + SGS G F WS+++++ + + + W I+ Sbjct: 243 MSLSGSQSQVINDKGKKLFVQRGEGNWSIVAVVNKRDLSDEIISWSIRYGAIAVGSLIIS 302 Query: 240 XXIAWFLWKMVYVPLQQFNHQIKSIA--QRNTAVTEVTRIXXXXXPEFDFLLKQLQNMKN 297 +AW W+ + L +IK Q + + I EFD ++ + M+ Sbjct: 303 LLLAWMTWRFINQKLSLLKEEIKQTTDLQFDRPYVPMNII------EFDEVVDRFYLMRT 356 Query: 298 QIAELIQEVEVKEKGRADLEVEKLLYQINPHFLMNTLDTVHWLAVMNGQKDIDKLVVSLN 357 +I +LI EVE KEK + LEV+KL YQINPHF+ NTL+T+ W+A M+ Q++I LV + Sbjct: 357 RIRDLIVEVEEKEKNKRKLEVQKLKYQINPHFIHNTLNTIQWIARMHKQEEIVNLVSIFS 416 Query: 358 KLLYYNLGKRGLVSTIREEIDSIRQYLTLQQVRYDFGFDVRIHVDDDVLELPIPRFILQP 417 ++L+YNLGK G + +REEI +++ Y+ LQ++RY+ F V ++ D ELPI RF++QP Sbjct: 417 RILHYNLGKEGEIVHLREEISALKDYVALQKIRYNHHFHVLFEIEPDTEELPIIRFLIQP 476 Query: 418 VLENSLYHGLHDE-GYIQVEVGKE-EGQIIISVYDNGAGISAEEIAKLLHQQQVEQQKAG 475 ++EN++YH D+ G I V V KE E II V DNG G+ E I +LL+ E++K+G Sbjct: 477 LVENAMYHAFTDDNGQITVRVFKENEAYFIIEVEDNGQGMDTETIQRLLYSDN-EKRKSG 535 Query: 476 MGIGMSYVKRMIENQYGGLASLEIHSELGQGTTVFLKLPSME 517 MGIG+ +V MI +G EI SELG+GT + ++LP ++ Sbjct: 536 MGIGLKFVNHMIREYFGEEHRFEISSELGKGTMIRIRLPILD 577 >C4ZHY0.1 C4ZHY0_9FIRM Two-component sensor histidine kinase Length = 383 Score = 186 bits (473), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 115/335 (34%), Positives = 188/335 (56%), Gaps = 10/335 (2%) Query: 192 QNGYYWFESTSNQGWSVISLIPVNEYNQQKNRWVIQMIYXXXXXXXXXXXIAWFLWKMVY 251 Q GY S G++ +P N Y ++ N W ++++ +L++++ Sbjct: 38 QEGYKIMVYRSTIGYANAIALPENIYQKEMNMWRLKLVVIILSAFGIFSCSVIYLYRLIC 97 Query: 252 VPLQQFNHQIKSIAQRNTAVTEVTRIXXXXXPEFDFLLKQLQNMKNQIAELIQEVEVKEK 311 PL Q QI + N A+ + EFD L+ +++ MK QI LI +V KEK Sbjct: 98 KPLNQLQKQIIQVG--NGALHGERQ--EYEIKEFDDLMHEVEQMKEQIRNLIDDVVEKEK 153 Query: 312 GRADLEVEKLLYQINPHFLMNTLDTVHWLAVMNGQKDIDKLVVSLNKLLYYNLGKRGLVS 371 E EKLLYQINPHFL+NTL++V W+A M+ Q +I + V L +LL YNLGK G+ + Sbjct: 154 NIQRTEYEKLLYQINPHFLLNTLNSVQWMARMSKQNNIMEFVQRLKRLLSYNLGKEGMQT 213 Query: 372 TIREEIDSIRQYLTLQQVRYDFGFDVRIHVDDDVLELPIPRFILQPVLENSLYHGLHDEG 431 T+R EID ++ Y+ L+Q+RYDF ++ + + LE P R +LQP++EN++ +GL ++ Sbjct: 214 TLRTEIDIVKDYIALEQMRYDFVIEMNVE-EGRYLEQPTVRMLLQPLVENAIRYGLGNDE 272 Query: 432 YIQVEVGKE--EGQIIISVYDNGAGISAEEIAKL---LHQQQVEQQKAGMGIGMSYVKRM 486 I ++V ++ G I++ D+G G++ EEI ++ + Q GIG+ YVK M Sbjct: 273 KITIQVFEDNIRGLAGITILDSGNGLTQEEIYQINEPFDYDVKKMQHGNRGIGLRYVKAM 332 Query: 487 IENQYGGLASLEIHSELGQGTTVFLKLPSMEVLPN 521 +++ Y G +L ++ + G GT + + +P E L N Sbjct: 333 LDSFYEGETTLFVNCKKGYGTKITILIPIQEELRN 367 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.318 0.137 0.392 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,997,946,877 Number of extensions: 129560727 Number of successful extensions: 358266 Number of sequences better than 1.0e-05: 2219 Number of HSP's gapped: 358651 Number of HSP's successfully gapped: 2219 Length of query: 522 Length of database: 3,060,696,203 Length adjustment: 140 Effective length of query: 382 Effective length of database: 1,741,754,103 Effective search space: 665350067346 Effective search space used: 665350067346 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 134 (56.2 bits)