BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0586.0070.p (698 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KIB4.1 B3KIB4_9BACI DNA topoisomerase EC=5.99.1.2 1230 0.0 B1DLV9.1 B1DLV9_9BACL DNA topoisomerase EC=5.99.1.2 1130 0.0 Q9KA23.1 TOP1_BACHD DNA topoisomerase 1 EC=5.99.1.2 1009 0.0 Q5WFP7.1 Q5WFP7_BACSK DNA topoisomerase EC=5.99.1.2 979 0.0 C0ZFB0.1 C0ZFB0_BREBN DNA topoisomerase I EC=5.99.1.2 971 0.0 >B3KIB4.1 B3KIB4_9BACI DNA topoisomerase EC=5.99.1.2 Length = 699 Score = 1230 bits (3182), Expect = 0.0, Method: Compositional matrix adjust. Identities = 588/698 (84%), Positives = 639/698 (91%) Query: 1 MADALVIVESPAKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFSPKYITIRGK 60 MAD+LVIVESPAKAKTIGKYLGSKYIVKASMGH+RDLPKSQIGVEVENDF+PKYITIRGK Sbjct: 1 MADSLVIVESPAKAKTIGKYLGSKYIVKASMGHVRDLPKSQIGVEVENDFNPKYITIRGK 60 Query: 61 GSILKELKDASKKVKKVYLAADPDREGEAIAWHLAHALDLDNSEECRVVFNEITKQAVKD 120 GS+LKELKDASKKVKKVYLAADPDREGEAIAWHLAHAL+LD+++ RVVFNEITK AVKD Sbjct: 61 GSVLKELKDASKKVKKVYLAADPDREGEAIAWHLAHALELDDTQSLRVVFNEITKTAVKD 120 Query: 121 AFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIIMDREN 180 AFKTPRKINMDLVNAQQARRILDRLVGYKISP+LWKKVKKGLSAGRVQSVAVKII+DREN Sbjct: 121 AFKTPRKINMDLVNAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVAVKIILDREN 180 Query: 181 EISAFVPTEYWSITAKLGIRDALFEAKFHKLNGEKKELGNENDVKEVLDAIKDAAFKVSE 240 EISAFVP EYW+ITAKL I+ + FEAKF +LNG KKEL NE +V E+L+AI+DA+FKV E Sbjct: 181 EISAFVPEEYWTITAKLAIKGSAFEAKFTQLNGAKKELTNEQEVNEILEAIRDASFKVGE 240 Query: 241 VKEKERQRHPSAPFTTSSLQQEAARKLGFRAAKTMSVAQQLYEGVELGKEGTVGLITYMR 300 VKE+ERQRHPS PFTTSSLQQEAARKLGFRAAKTMSVAQQLYEGVELGKEGTVGLITYMR Sbjct: 241 VKERERQRHPSPPFTTSSLQQEAARKLGFRAAKTMSVAQQLYEGVELGKEGTVGLITYMR 300 Query: 301 TDSTRLSATAQEEAKELILAKYGEKFVPESPRQYSKKAAGAQDAHEAIRPTSALREPEMV 360 TDSTR+S TAQEEAKE I KYG+ FVPESPRQYSKKAA AQDAHEAIRPTS LR+PE + Sbjct: 301 TDSTRISGTAQEEAKEYITEKYGDPFVPESPRQYSKKAANAQDAHEAIRPTSVLRDPESM 360 Query: 361 KEFMSRDQFRLYKLIWERFVSSQMSSAVLDTLSVDITAGTAVFRAVGSKVSFPGFMKVYV 420 K +MSRDQ RLYKL+WERFV+SQMSSAVLDTLSVDITAG VFRA GSKV FPGFMKVYV Sbjct: 361 KPYMSRDQLRLYKLVWERFVASQMSSAVLDTLSVDITAGNTVFRATGSKVRFPGFMKVYV 420 Query: 421 EGNDDGTTDEEKFLPPLQAGDDLKKQEIEPKQHFTQPPPRYTEARLVKTLEELGIGRPST 480 EGNDDGTT+E+K+LP L +GD L+KQ+IEPKQHFTQPPPRYTEARLV+TLEELGIGRPST Sbjct: 421 EGNDDGTTEEDKYLPELHSGDILEKQDIEPKQHFTQPPPRYTEARLVRTLEELGIGRPST 480 Query: 481 YAPTLETIQKRGYVAIEEKKFMPTELGELIIEQMEQFFPEILDVEFTAHMEDDLDHVEDG 540 YAPTLETIQKRGYVAIEEKKFMPTELGEL+IEQMEQFFPEIL+VEFTA+ME+DLDHVE+G Sbjct: 481 YAPTLETIQKRGYVAIEEKKFMPTELGELVIEQMEQFFPEILNVEFTANMEEDLDHVEEG 540 Query: 541 EEDWVKVLAEFYTSFEKRLVFAXXXXXXXXXXXXVSDEMCEKCGKPMVYKLGRFGKFLAC 600 EDWVKVLAEFY SFEKRL A VSDE+CEKCGKP+VYKLGRFGKFLAC Sbjct: 541 SEDWVKVLAEFYESFEKRLEVAEEEMKEIEIEDEVSDEICEKCGKPLVYKLGRFGKFLAC 600 Query: 601 SGFPDCRNTKPIVKDIGVSCPKCHEGKVVERRSKKGRVFYGCDQYPGCDFVSWDRPSVKP 660 SGFP+CRNTKPIVKDIGVSCPKC EG VVERRSKKGRVF+GCD+YP CDFVSWD+PS KP Sbjct: 601 SGFPECRNTKPIVKDIGVSCPKCKEGHVVERRSKKGRVFFGCDRYPECDFVSWDKPSTKP 660 Query: 661 CPVCGSWMIEKRSKQGTKLQCTSCDHTEAVLEGEELAE 698 CP C S M+EK+SKQG KLQCTSCD++E V E +E A+ Sbjct: 661 CPNCSSLMVEKKSKQGIKLQCTSCDYSEMVEEQDEAAD 698 >B1DLV9.1 B1DLV9_9BACL DNA topoisomerase EC=5.99.1.2 Length = 698 Score = 1130 bits (2923), Expect = 0.0, Method: Compositional matrix adjust. Identities = 535/695 (76%), Positives = 600/695 (86%) Query: 1 MADALVIVESPAKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFSPKYITIRGK 60 MAD+LVIVESPAKAKTIGKYLGSKYIVKASMGHIRDLPKSQ GVEVEN F PKYITIRGK Sbjct: 1 MADSLVIVESPAKAKTIGKYLGSKYIVKASMGHIRDLPKSQTGVEVENGFQPKYITIRGK 60 Query: 61 GSILKELKDASKKVKKVYLAADPDREGEAIAWHLAHALDLDNSEECRVVFNEITKQAVKD 120 GS+LKELKDASKKVK V+LAADPDREGEAIAWHLAH L+LD ++ CRVVFNEITKQAVKD Sbjct: 61 GSVLKELKDASKKVKHVFLAADPDREGEAIAWHLAHYLELDETDTCRVVFNEITKQAVKD 120 Query: 121 AFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIIMDREN 180 AFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSV VK+I+DREN Sbjct: 121 AFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVCVKLIIDREN 180 Query: 181 EISAFVPTEYWSITAKLGIRDALFEAKFHKLNGEKKELGNENDVKEVLDAIKDAAFKVSE 240 EI AF+P EYWSITAKL + FEAK+H + GEK+EL NE +++ +L A+ FKV+E Sbjct: 181 EIDAFIPEEYWSITAKLTQQGVPFEAKYHSIKGEKRELHNEEEMQAILAALSGNQFKVAE 240 Query: 241 VKEKERQRHPSAPFTTSSLQQEAARKLGFRAAKTMSVAQQLYEGVELGKEGTVGLITYMR 300 VKEKER R+P+ PF TSSLQQEAARKLGFRA+KTMSVAQQLYEGVELGKEGTVGLITYMR Sbjct: 241 VKEKERLRNPAPPFITSSLQQEAARKLGFRASKTMSVAQQLYEGVELGKEGTVGLITYMR 300 Query: 301 TDSTRLSATAQEEAKELILAKYGEKFVPESPRQYSKKAAGAQDAHEAIRPTSALREPEMV 360 TDSTR+S AQEEAKE I KYG F PE PR Y+KK + AQDAHEAIRPTS LR+PE + Sbjct: 301 TDSTRISPVAQEEAKEYIEGKYGPSFYPEQPRVYTKKNSNAQDAHEAIRPTSTLRDPESM 360 Query: 361 KEFMSRDQFRLYKLIWERFVSSQMSSAVLDTLSVDITAGTAVFRAVGSKVSFPGFMKVYV 420 K F+SRDQFRLYKL+WERFVSSQM+SAVLDT++VD+ +G FRA GSK+ F GFMKVYV Sbjct: 361 KPFLSRDQFRLYKLVWERFVSSQMASAVLDTMTVDLASGDVTFRASGSKIKFAGFMKVYV 420 Query: 421 EGNDDGTTDEEKFLPPLQAGDDLKKQEIEPKQHFTQPPPRYTEARLVKTLEELGIGRPST 480 EGNDDGT +E KFLPP GD + IEPKQHFTQPPPRY+EARLVKTLEELGIGRPST Sbjct: 421 EGNDDGTEEEHKFLPPFAIGDVVTSDSIEPKQHFTQPPPRYSEARLVKTLEELGIGRPST 480 Query: 481 YAPTLETIQKRGYVAIEEKKFMPTELGELIIEQMEQFFPEILDVEFTAHMEDDLDHVEDG 540 YAPTLETIQKRGYVAIEEKKF+PTELG+L+ + ME+FFPEILD EFTA ME DLDHVEDG Sbjct: 481 YAPTLETIQKRGYVAIEEKKFIPTELGDLVNQLMEEFFPEILDSEFTAKMETDLDHVEDG 540 Query: 541 EEDWVKVLAEFYTSFEKRLVFAXXXXXXXXXXXXVSDEMCEKCGKPMVYKLGRFGKFLAC 600 EDWV+VL++FY SFEKRL A VSDE+CEKCG+ MVYK+GRFGKFLAC Sbjct: 541 MEDWVRVLSQFYESFEKRLEVAEEEMKEVEIQDEVSDEICEKCGRHMVYKMGRFGKFLAC 600 Query: 601 SGFPDCRNTKPIVKDIGVSCPKCHEGKVVERRSKKGRVFYGCDQYPGCDFVSWDRPSVKP 660 SGFPDCRNTKPIVKDIGV+CPKC EGK++ERRSKKGR+FYGCD YP CD+VSWD+P+ KP Sbjct: 601 SGFPDCRNTKPIVKDIGVTCPKCGEGKIIERRSKKGRIFYGCDTYPACDYVSWDKPTNKP 660 Query: 661 CPVCGSWMIEKRSKQGTKLQCTSCDHTEAVLEGEE 695 CP C S ++EKR++ G KLQC +CD++E + E E+ Sbjct: 661 CPNCDSMLVEKRNRSGAKLQCPNCDYSEEISEDEQ 695 >Q9KA23.1 TOP1_BACHD DNA topoisomerase 1 EC=5.99.1.2 Length = 690 Score = 1009 bits (2609), Expect = 0.0, Method: Compositional matrix adjust. Identities = 467/688 (67%), Positives = 574/688 (83%), Gaps = 1/688 (0%) Query: 1 MADALVIVESPAKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFSPKYITIRGK 60 MAD LVIVESPAKAKTIGKYLG KY VKASMGH+RDLPKSQ+GV++E+++SP+YITIRGK Sbjct: 1 MADYLVIVESPAKAKTIGKYLGKKYTVKASMGHVRDLPKSQMGVDIEDEYSPRYITIRGK 60 Query: 61 GSILKELKDASKKVKKVYLAADPDREGEAIAWHLAHALDLDNSEECRVVFNEITKQAVKD 120 G +LKELK A+KKVK+VYLAADPDREGEAIAWHLAH+LD+D + ECRVVFNEITKQA+KD Sbjct: 61 GPVLKELKSAAKKVKRVYLAADPDREGEAIAWHLAHSLDIDETSECRVVFNEITKQAIKD 120 Query: 121 AFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIIMDREN 180 AFK+PR INMDLV+AQQARR+LDRLVGY ISPLLWKKVKKGLSAGRVQSVAVK+I+DRE Sbjct: 121 AFKSPRPINMDLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIDREK 180 Query: 181 EISAFVPTEYWSITAKLGIRDALFEAKFHKLNGEKKELGNENDVKEVLDAIKDAAFKVSE 240 EI AF P EYWSI + FEAKF+ NG+K EL +E+DV VL +K F V Sbjct: 181 EIQAFEPEEYWSIQGTFALDGEPFEAKFYGTNGKKVELKSEDDVNNVLAKLKGDQFHVDS 240 Query: 241 VKEKERQRHPSAPFTTSSLQQEAARKLGFRAAKTMSVAQQLYEGVELGKEGTVGLITYMR 300 V++KER+R+P +PFTTSSLQQEAARKL FRA KTM +AQQLYEG++LGKEGTVGLITYMR Sbjct: 241 VQKKERKRNPVSPFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIDLGKEGTVGLITYMR 300 Query: 301 TDSTRLSATAQEEAKELILAKYGEKFVPESPRQYSKKAAGAQDAHEAIRPTSALREPEMV 360 TDSTR+S TA+ E KE I +K+G+++ ++ + KK +QDAHEAIRPTS R+P+ + Sbjct: 301 TDSTRISDTAKAETKEYIESKFGKEYA-QNGTKAVKKDKKSQDAHEAIRPTSVERDPKSL 359 Query: 361 KEFMSRDQFRLYKLIWERFVSSQMSSAVLDTLSVDITAGTAVFRAVGSKVSFPGFMKVYV 420 KE++SRDQ RLYKLIWER V+SQM+ A++DT++VD++ +FRA GSKV FPGFMKVY+ Sbjct: 360 KEYLSRDQLRLYKLIWERLVASQMAPAIMDTMTVDLSNEGVLFRATGSKVKFPGFMKVYI 419 Query: 421 EGNDDGTTDEEKFLPPLQAGDDLKKQEIEPKQHFTQPPPRYTEARLVKTLEELGIGRPST 480 EGND+G +E++ LP LQ G + K+EIEP QHFTQPPPRYTEARLVKT+EELGIGRPST Sbjct: 420 EGNDEGKKEEDRLLPNLQEGQTVTKEEIEPSQHFTQPPPRYTEARLVKTMEELGIGRPST 479 Query: 481 YAPTLETIQKRGYVAIEEKKFMPTELGELIIEQMEQFFPEILDVEFTAHMEDDLDHVEDG 540 YAPTL+TIQKRGYVA++E++F+PTELGE+++E M +FFPEILDVEFTA MEDDLD +E+G Sbjct: 480 YAPTLDTIQKRGYVALDERRFVPTELGEIVLELMTEFFPEILDVEFTAKMEDDLDSIEEG 539 Query: 541 EEDWVKVLAEFYTSFEKRLVFAXXXXXXXXXXXXVSDEMCEKCGKPMVYKLGRFGKFLAC 600 ++ W+K++ +FY FE+RL A + EMCEKCG MVYK+GR+GKF+AC Sbjct: 540 KQQWIKIIDDFYKGFEERLKVAEEEMKEVEIKDEPTGEMCEKCGHEMVYKMGRYGKFMAC 599 Query: 601 SGFPDCRNTKPIVKDIGVSCPKCHEGKVVERRSKKGRVFYGCDQYPGCDFVSWDRPSVKP 660 S FPDCRNTKPIVK+IGV CPKC +G++VER+SKK RVFYGC+QYP CDFVSWD+P + Sbjct: 600 SNFPDCRNTKPIVKEIGVKCPKCEKGEIVERKSKKRRVFYGCNQYPECDFVSWDKPIARS 659 Query: 661 CPVCGSWMIEKRSKQGTKLQCTSCDHTE 688 CP C S+++EKR+K+ ++QC+SCD+ E Sbjct: 660 CPKCSSYLVEKRTKKQVQVQCSSCDYKE 687 >Q5WFP7.1 Q5WFP7_BACSK DNA topoisomerase EC=5.99.1.2 Length = 690 Score = 979 bits (2532), Expect = 0.0, Method: Compositional matrix adjust. Identities = 456/688 (66%), Positives = 560/688 (81%), Gaps = 1/688 (0%) Query: 1 MADALVIVESPAKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFSPKYITIRGK 60 M+D LVIVESPAKAKTIGKYLG KY+VKASMGH+RDLPKSQ+GV VE+++ P+YITIRGK Sbjct: 1 MSDYLVIVESPAKAKTIGKYLGKKYVVKASMGHVRDLPKSQMGVSVEDNYEPRYITIRGK 60 Query: 61 GSILKELKDASKKVKKVYLAADPDREGEAIAWHLAHALDLDNSEECRVVFNEITKQAVKD 120 G +LKELK A+KK K+VYLAADPDREGEAIAWHLAH+L++D + +CRVVFNEITK A+KD Sbjct: 61 GPVLKELKTAAKKAKRVYLAADPDREGEAIAWHLAHSLNIDENSDCRVVFNEITKTAIKD 120 Query: 121 AFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIIMDREN 180 AFK PR INMDLV+AQQARRILDRLVGY ISPLLWKKVKKGLSAGRVQSVAVK+I DRE Sbjct: 121 AFKHPRPINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKLITDREK 180 Query: 181 EISAFVPTEYWSITAKLGIRDALFEAKFHKLNGEKKELGNENDVKEVLDAIKDAAFKVSE 240 EI FVP EYWSIT + D FEAKF+ NG+K+ L +E +V EVL IK F V++ Sbjct: 181 EIQQFVPEEYWSITGTFLLGDEPFEAKFYGRNGKKESLTSEENVNEVLKQIKGKQFAVAD 240 Query: 241 VKEKERQRHPSAPFTTSSLQQEAARKLGFRAAKTMSVAQQLYEGVELGKEGTVGLITYMR 300 V +KER+R+P +PFTTSSLQQEAARKL FRA KTM +AQQLYEG++LGKEGTVGLITYMR Sbjct: 241 VVKKERRRNPVSPFTTSSLQQEAARKLNFRAKKTMLIAQQLYEGIDLGKEGTVGLITYMR 300 Query: 301 TDSTRLSATAQEEAKELILAKYGEKFVPESPRQYSKKAAGAQDAHEAIRPTSALREPEMV 360 TDSTR+S TA++E E I + YGE++ + R+ K+ AQDAHEAIRPTS EP+ + Sbjct: 301 TDSTRISDTAKQETYEYIRSTYGEEYARKGERK-QKQDKNAQDAHEAIRPTSVKYEPKQL 359 Query: 361 KEFMSRDQFRLYKLIWERFVSSQMSSAVLDTLSVDITAGTAVFRAVGSKVSFPGFMKVYV 420 KE++SRDQ RLY+LIWER V+S+M+ A++DT++VD+ FRA GSKV FPGFMKVY+ Sbjct: 360 KEYLSRDQLRLYRLIWERLVASEMAPAIMDTMTVDLENNGVKFRANGSKVKFPGFMKVYI 419 Query: 421 EGNDDGTTDEEKFLPPLQAGDDLKKQEIEPKQHFTQPPPRYTEARLVKTLEELGIGRPST 480 EGNDD +E++ LP L G ++K E+ P QHFTQPPPRYTEARLVKTLEELGIGRPST Sbjct: 420 EGNDDNKKEEDRLLPALAKGQQVEKTEVTPNQHFTQPPPRYTEARLVKTLEELGIGRPST 479 Query: 481 YAPTLETIQKRGYVAIEEKKFMPTELGELIIEQMEQFFPEILDVEFTAHMEDDLDHVEDG 540 YAPTL+TIQ+RGYVA++EK+F+PTELGE++++ + +FFPEILDVEFTA ME+DLD +EDG Sbjct: 480 YAPTLDTIQRRGYVALDEKRFVPTELGEIVLDLIVEFFPEILDVEFTAKMEEDLDSIEDG 539 Query: 541 EEDWVKVLAEFYTSFEKRLVFAXXXXXXXXXXXXVSDEMCEKCGKPMVYKLGRFGKFLAC 600 ++W+ ++ +FY SFEKRL A + E CEKCG MVYK+GR+GKF+AC Sbjct: 540 RDNWISIIDQFYQSFEKRLKVAEEEMEEVEIKDEPAGEDCEKCGHEMVYKMGRYGKFMAC 599 Query: 601 SGFPDCRNTKPIVKDIGVSCPKCHEGKVVERRSKKGRVFYGCDQYPGCDFVSWDRPSVKP 660 S FP+CRNTK IVK+IGV+CP C +G +VER+SKK R+FYGCD+YP C+FVSWD+P +P Sbjct: 600 SNFPECRNTKAIVKEIGVTCPTCKQGNIVERKSKKRRIFYGCDRYPDCEFVSWDKPISRP 659 Query: 661 CPVCGSWMIEKRSKQGTKLQCTSCDHTE 688 CP C ++EK+SK+G + CTSCD+ E Sbjct: 660 CPKCQGLLVEKKSKKGVFVACTSCDYEE 687 >C0ZFB0.1 C0ZFB0_BREBN DNA topoisomerase I EC=5.99.1.2 Length = 692 Score = 971 bits (2511), Expect = 0.0, Method: Compositional matrix adjust. Identities = 471/690 (68%), Positives = 559/690 (81%), Gaps = 4/690 (0%) Query: 1 MADALVIVESPAKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFSPKYITIRGK 60 MAD LVIVESP KAKTIGKYLGSKYIVKAS+GH+RDLPKSQ+GV+V ++F PKYITIRGK Sbjct: 1 MADTLVIVESPTKAKTIGKYLGSKYIVKASIGHVRDLPKSQMGVDVTHNFEPKYITIRGK 60 Query: 61 GSILKELKDASKKVKKVYLAADPDREGEAIAWHLAHALDLDNSEECRVVFNEITKQAVKD 120 G +LK LKDA+KKVKKVYLAADPDREGEAIAWHLA L LD ++ RVVFNEITK A+K+ Sbjct: 61 GDVLKGLKDAAKKVKKVYLAADPDREGEAIAWHLAQYLGLDMNQPLRVVFNEITKDAIKE 120 Query: 121 AFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIIMDREN 180 AFK PR INMDLVNAQQARRILDRLVGY ISP+LWKKV+KGLSAGRVQSVAVK+IMDRE Sbjct: 121 AFKHPRHINMDLVNAQQARRILDRLVGYNISPILWKKVRKGLSAGRVQSVAVKLIMDRER 180 Query: 181 EISAFVPTEYWSITAKLGIRDALFEAKFHKLNGEKKELGNENDVKEVLDAIKDAAFKVSE 240 EI F+P EYW+I + L AKF+ EK EL +E+DV VL +K+ + V + Sbjct: 181 EIQEFIPEEYWTIASTLISDGKEINAKFYGYGDEKVELHSEDDVAAVLKRMKNKPYVVQK 240 Query: 241 VKEKERQRHPSAPFTTSSLQQEAARKLGFRAAKTMSVAQQLYEGVELG-KEGTVGLITYM 299 V ++ER+R+P+ PF TSSLQQEAARKL FR +KTM +AQ+LYEG+++G KEG VGLITYM Sbjct: 241 VTKRERKRNPAPPFITSSLQQEAARKLNFRTSKTMRIAQELYEGIDVGNKEGAVGLITYM 300 Query: 300 RTDSTRLSATAQEEAKELILAKYGEKFVPESPRQYSKKAAGAQDAHEAIRPTSALREPEM 359 RTDSTRLS TAQ EAKE IL KYG +V PR +K AQDAHEAIRPT +R P+ Sbjct: 301 RTDSTRLSVTAQNEAKEYILEKYGPDYVLSEPRNQAKN-ENAQDAHEAIRPTGVMRTPDE 359 Query: 360 VKEFMSRDQFRLYKLIWERFVSSQMSSAVLDTLSVDITAGTAVFRAVGSKVSFPGFMKVY 419 +KE++SRDQ RLY+LIWERF++SQMSSAVLDT+SVDI AG FRA GSKV FPGFMKVY Sbjct: 360 IKEYLSRDQLRLYRLIWERFLASQMSSAVLDTMSVDIDAGGVTFRATGSKVKFPGFMKVY 419 Query: 420 VEGNDDGTTDEEKFLPPLQAGDDLKKQEIEPKQHFTQPPPRYTEARLVKTLEELGIGRPS 479 +EGNDDG T+EE FLPP++ G L ++EIEP QHFTQPPPR++EAR++K++EE+GIGRPS Sbjct: 420 IEGNDDG-TEEESFLPPIEEGQILDQKEIEPSQHFTQPPPRFSEARMLKSMEEMGIGRPS 478 Query: 480 TYAPTLETIQKRGYVAIEEKKFMPTELGELIIEQMEQFFPEILDVEFTAHMEDDLDHVED 539 TYAPTLETIQKRGYVA+EEK+F+PTELGE++I +E+FFPEIL+VEFTAHME LD++E Sbjct: 479 TYAPTLETIQKRGYVALEEKRFVPTELGEIVITLVEEFFPEILNVEFTAHMESGLDNIEA 538 Query: 540 GEEDWVKVLAEFYTSFEKRLVFAXXXXXXXXXXXXVSDEMCEKCGKPMVYKLGRFGKFLA 599 G +WV+VL +FY F KR+V A SDE CE CG MVYKLGRFGKFLA Sbjct: 539 GNTNWVQVLDDFYQDFAKRVVVAEEEMKEVELKVEESDETCELCGSVMVYKLGRFGKFLA 598 Query: 600 CSGFPDCRNTKPIVKDIGVSCPKCHEGKVVERRSKKGRVFYGCDQYPGCDFVSWDRPSVK 659 CSGFPDCRNTKPIVK+IGV CP+C G+++ER+SKK R+FYGC+QYP CDFVSWD+P + Sbjct: 599 CSGFPDCRNTKPIVKEIGVKCPQCETGEIIERKSKKSRIFYGCNQYPECDFVSWDKPIAR 658 Query: 660 PCPVCGSWMIE-KRSKQGTKLQCTSCDHTE 688 PCP C S ++E KR KQG + CT CD+ E Sbjct: 659 PCPKCSSMLVEKKRKKQGVSIICTKCDYQE 688 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.316 0.133 0.386 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 4,025,446,480 Number of extensions: 170182727 Number of successful extensions: 486709 Number of sequences better than 1.0e-05: 3545 Number of HSP's gapped: 469663 Number of HSP's successfully gapped: 4361 Length of query: 698 Length of database: 3,060,696,203 Length adjustment: 143 Effective length of query: 555 Effective length of database: 1,713,491,058 Effective search space: 950987537190 Effective search space used: 950987537190 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 135 (56.6 bits)