BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0580.0046.p (574 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KA48.1 B3KA48_9BACI Histidine kinase internal region 833 0.0 B1D770.1 B1D770_9BACL Integral membrane sensor signal transducti... 285 9e-75 B3KK08.1 B3KK08_9BACI Histidine kinase internal region 262 6e-68 B1DAF1.1 B1DAF1_9BACL Integral membrane sensor signal transducti... 221 1e-55 Q8R7Q4.1 Q8R7Q4_THETN Predicted ATPase 217 3e-54 >B3KA48.1 B3KA48_9BACI Histidine kinase internal region Length = 574 Score = 833 bits (2152), Expect = 0.0, Method: Compositional matrix adjust. Identities = 399/574 (69%), Positives = 478/574 (83%), Gaps = 2/574 (0%) Query: 1 MKLRRKILFAIILLVFIPVIVMGSVTYINFSNAMEKKSSNFYWISLLETDRKLKFALSEI 60 MKLRRKIL AIILLVFIPVI +G V+Y +FS AMEKKS++FYWISLLETDRKLKFAL+EI Sbjct: 1 MKLRRKILLAIILLVFIPVIALGGVSYYSFSEAMEKKSNDFYWISLLETDRKLKFALNEI 60 Query: 61 TSITNSAITQPAIQQSLKQPDFVLTYDRKQEINNLLINHPMITSFSLYGKDRLLYQYNAP 120 T+I+NSAITQ ++QQ LKQP++ +TY+R+QEINNL INHPMI SF+ Y DRL+Y N Sbjct: 61 TTISNSAITQQSVQQMLKQPEYAVTYERRQEINNL-INHPMIASFAFYSNDRLMYNTNGG 119 Query: 121 MSFADMRQQTWYGAMERAEGRPVWXXXXXXXXXXXXXXVLVQARIIKDYYSLEDIGYLVV 180 M ++RQQ WY A+E+AEGRPVW VL+Q+R+IKDYYSLEDIG +V+ Sbjct: 120 MELQELRQQAWYEAVEKAEGRPVWVGPGENGSAADGAPVLIQSRVIKDYYSLEDIGTVVI 179 Query: 181 YVKPDLLDQIFWEAATLKKGDILLVNKQGNIVFNKSGEHIGQRTDFPFLQENYNQE-QDY 239 YVKPDLLDQ+FWEAATLK+GDILLVN+QG+IVF+KSG HIG+RT+FPFL ++Y + Y Sbjct: 180 YVKPDLLDQVFWEAATLKQGDILLVNQQGHIVFSKSGGHIGERTEFPFLSDSYKTNGKGY 239 Query: 240 YIDNYQGEKSLITFLPSHNADWYLAAITPMNLISSESVSIRNIALILGAVSLISAFLFDH 299 YID Y GEKSLIT+ PSHN DW+L AITP LIS+ESV IRN+ALILG +SL+SAFLFD Sbjct: 240 YIDQYAGEKSLITYSPSHNKDWFLVAITPSKLISAESVPIRNLALILGLISLVSAFLFDR 299 Query: 300 YFIRRLVRSINSAVNGMKRVKQGIFTPINVPARADDESDSLIDGFNRMSSQISELIEQVQ 359 +F+RR+VRSI SAVNGMKRVKQGIF PI A+DE+D LIDGFNRMS+QI ELI QV+ Sbjct: 300 FFVRRMVRSIISAVNGMKRVKQGIFVPIPSHNVAEDETDLLIDGFNRMSTQIQELIGQVE 359 Query: 360 TEQGRKKEAEMQALMAQINPHFIYNSLESINSMAVLAGNRDISKMVVSLGRLLRISISQN 419 TEQ RKKEAE+QAL+AQINPHFIYNSLESINSMAVL GN+DISKMV+SLG+LLRISIS++ Sbjct: 360 TEQARKKEAELQALVAQINPHFIYNSLESINSMAVLQGNKDISKMVISLGKLLRISISEH 419 Query: 420 QELIPLQMEFEHVRHYLDIQKFRFEDKFSYALELPASLKNLMTQKLIVQPIVENALYHAI 479 ELIPL ME EHV+HY+ IQKFRFE+KF Y +ELP L++ +TQKLIVQPIVENALYH I Sbjct: 420 HELIPLSMELEHVQHYMRIQKFRFEEKFDYGIELPNELRHYVTQKLIVQPIVENALYHGI 479 Query: 480 EQMEEHGVITISAEETGKDLIIIVKDNGPGFELATLMSLWNEERTNPKKYSDSGVGLKNV 539 E MEE G+I+I E G+D++I V+DNGPGF+ TLM LWN + KKY ++GVGLKNV Sbjct: 480 EPMEESGLISIKVSENGEDIVIDVEDNGPGFDPETLMKLWNSDPGQLKKYRENGVGLKNV 539 Query: 540 HERLNIRFGNPYGIVVCSSPGFGSTICIRIPRIL 573 HERL IRFG+ YG+++CSSPG+GS I IRIP+IL Sbjct: 540 HERLRIRFGSRYGLMICSSPGYGSLIRIRIPKIL 573 >B1D770.1 B1D770_9BACL Integral membrane sensor signal transduction histidine kinase Length = 606 Score = 285 bits (729), Expect = 9e-75, Method: Compositional matrix adjust. Identities = 186/604 (30%), Positives = 308/604 (50%), Gaps = 37/604 (6%) Query: 1 MKLRRKILFAIILLVFIPVIVMGSVTYINFSNAMEKKSSNFYWISLLETDRKLKFALSEI 60 M LR K++ A I LV +P+I +G V+++N + +EKK S ISL +K+ E+ Sbjct: 1 MNLRPKLMLAFIFLVVVPMIGLGIVSFLNTESVLEKKYSEQTEISLKAVGGNIKYFFKEL 60 Query: 61 TSITNSAITQPAIQQSLKQPDFVLTYD---------RKQEINNLLINHPMITSFSLYGKD 111 +++ +T +Q +L + + D ++E+ +L HP ++ LY D Sbjct: 61 DQLSDGNLTSSEVQDTLNYSKYYSSDDASTLIAINQSEKEMKRILFQHPAVSFVVLYAMD 120 Query: 112 RLLYQ-------YNAPMSFADMRQQTWYGAMERAEGRPVWXXXXXXXXXXXXXXVL-VQA 163 +++ P++F ++ Q Y + GRP W L Q Sbjct: 121 GTMFRAFRNDPTTFRPIAFEALKDQPLYNETIKLGGRPKWIGPYEHQELTGVEPPLFTQL 180 Query: 164 RIIKDYYSLEDIGYLVVYVKPD----LLDQIFWEAATLKKGDILLVNKQGNIVFNKSGEH 219 R++KDY +L D+G ++ K + +L+ A ++VN +G ++ + SG+H Sbjct: 181 RLVKDYETLADLGLMITQYKTEEVYSMLNTFLNPEAEGPNSRYVIVNSEGLVMLD-SGKH 239 Query: 220 IGQRTDFPFLQENYNQEQDYYID---NYQGEKSLITFLPSHNADWYLAAITPMNLISSES 276 + T+ Q Y + GE SL++ DW L ++ +++++E+ Sbjct: 240 F-EGTNISEYSSALPQNTADYSSARLRFNGEDSLVSSYNLGFNDWVLVSVKSWDMLTNEN 298 Query: 277 VSIRNIALILGAVSLISAFLFDHYFIRRLVRSINSAVNGMKRVKQGIFTPINVPARADDE 336 ++ + ++SA LF+ +F+ R+ +SI V M+ V+QG+ I V A+ DE Sbjct: 299 ERFVQWIGMITILCILSAILFNIFFVNRVAKSIIKVVRKMRLVEQGLLD-IRVNAQGKDE 357 Query: 337 SDSLIDGFNRMSSQISELIEQVQTEQGRKKEAEMQALMAQINPHFIYNSLESINSMAVLA 396 + L + FN M +I +L+ +V+TEQ RK+ AEM + AQI PHF++N+LESIN++A Sbjct: 358 TVLLANSFNSMVQRIGDLLTEVRTEQERKQHAEMMLMQAQIKPHFLFNTLESINALAAQN 417 Query: 397 GNRDISKMVVSLGRLLRISISQNQELIPLQMEFEHVRHYLDIQKFRFEDKFSYALELPAS 456 I MV L LLR S+ ++E+ L E EHVR YL+IQK+RFED F+Y L + Sbjct: 418 EGGKIMMMVRRLSNLLRTSMHHSEEIF-LSQEIEHVRSYLEIQKYRFEDLFTYELNVSEE 476 Query: 457 LKNLMTQKLIVQPIVENALYHAIEQMEE-HGVITISAEETGKDLIIIVKDNGPGFELATL 515 KL +QP+VEN++ H E +E+ G+ITI ++I+V DNG G TL Sbjct: 477 AFEYSILKLTLQPLVENSIQHGFEGLEDGAGMITIEVTVEAHQIVILVSDNGHGMNEQTL 536 Query: 516 MSLWNEE-------RTNPKKYSD-SGVGLKNVHERLNIRFGNPYGIVVCSSPGFGSTICI 567 E R N + + G+GL+NV +RL I +G YG+ +CS+ G+G+ I Sbjct: 537 KKFAEREQPLPSGKRRNAAELGERRGLGLRNVADRLRIHYGPSYGLRICSAEGYGTVIRC 596 Query: 568 RIPR 571 IP+ Sbjct: 597 TIPK 600 >B3KK08.1 B3KK08_9BACI Histidine kinase internal region Length = 620 Score = 262 bits (670), Expect = 6e-68, Method: Compositional matrix adjust. Identities = 185/610 (30%), Positives = 305/610 (50%), Gaps = 47/610 (7%) Query: 1 MKLRRKILFAIILLVFIPVIVMGSVTYINFSNAMEKKSSNFYWISLLETDRKLKFALSEI 60 M LR K+ A + L+ IP+ V+G T+ N++E+K S SL + E+ Sbjct: 3 MNLRNKLFTAFLGLIIIPLFVLGLFTFFITYNSIEEKYSQQAEYSLKAISYSILNVFKEM 62 Query: 61 TSITNSAITQPAIQQSL--KQPDF-----------VLTYDRKQEINNLLINHPMITSFSL 107 +T++ I +L K PD + DR++ NLL NHP I+ L Sbjct: 63 EYVTDNGIATSVFAMALNAKDPDAQNLIKESNADQLKLNDRQRSFRNLLYNHPAISYAFL 122 Query: 108 YGKDRLLYQYNAP-----------MSFADMRQQTWYGAMERAEGRPVWXXXXXXXXXXXX 156 Y ++ +AP + + + Y + + G P W Sbjct: 123 YHFNK----ESAPIPIFSKEDFRTLPYEQFKNSPLYEEVVKLNGIPKWLAPHEFPELTGA 178 Query: 157 XXVLVQARIIKDYYSLEDIGYLVVYVKPDLLDQIFWEAA---TLKKGDILLVNKQGNIVF 213 V Q R+IKD +L +G LVV +K ++IF L+ +LVN +G I+F Sbjct: 179 DPVFTQIRLIKDVTTLRKLGILVVQIKRWEFEEIFRNLTLPNNLQNTSFMLVNNEGFILF 238 Query: 214 NKSGEHIGQRTDFPFLQENYNQEQDY--YIDNYQGEKSLITFLPSHNADWYLAAITPMNL 271 + GQ +++ + +Q Y + + G++++++ ++ W + ++T N Sbjct: 239 DPQNGMDGQNIS-QYMKRDVEFKQGYQSFKAKFNGKENIVSIYHLNDYGWNIVSVTDWNS 297 Query: 272 ISSESVSIRNIALILGAVSLISAFLFDHYFIRRLVRSINSAVNGMKRVKQGIFTPINVPA 331 +S E S ++ + L++A +F+ F+ R+ +I V M+RV+ G V Sbjct: 298 LSQEVTSFAKWFFVIMGICLVTAIVFNRLFMNRITGTIAVIVRFMRRVEDGDLNA-RVEE 356 Query: 332 RADDESDSLIDGFNRMSSQISELIEQVQTEQGRKKEAEMQALMAQINPHFIYNSLESINS 391 + +DE L GFN + ++I+ L Q++ EQ +K +AEM+ L AQI PHF++N+LESIN Sbjct: 357 KGEDELLLLSKGFNNLMNRINNLFAQIKKEQRQKTDAEMRVLQAQIKPHFLFNTLESINV 416 Query: 392 MAVLAGNRDISKMVVSLGRLLRISISQNQELIPLQMEFEHVRHYLDIQKFRFEDKFSYAL 451 +AV R +S+MV L +LRISI Q++E I L E +H++ YL+IQKFRFED F Y + Sbjct: 417 LAVQNEGRKVSEMVYRLASILRISI-QDKEEITLDEEIKHLQSYLEIQKFRFEDLFEYEI 475 Query: 452 ELPASLKNLMTQKLIVQPIVENALYHAIEQMEEHGVITISAEETGKDLIIIVKDNGPGF- 510 ++P L + KL +QP+VEN++ H E + G I ISA + +++I V+DNG G Sbjct: 476 DVPKELMHSRILKLTLQPLVENSIQHGFEGISYTGWIRISAWKELGNVVIRVEDNGLGMT 535 Query: 511 -ELATLMSLWNEERTNPKKYS---------DSGVGLKNVHERLNIRFGNPYGIVVCSSPG 560 E ++ E P + + G+GL++V +RL I++G YG+ +CSS Sbjct: 536 SEQLSMFEYMVSEDGVPDQTTLQNLKVNQERRGLGLRSVADRLRIQYGPYYGLFICSSRP 595 Query: 561 FGSTICIRIP 570 G+ I IP Sbjct: 596 GGTVIQCVIP 605 >B1DAF1.1 B1DAF1_9BACL Integral membrane sensor signal transduction histidine kinase Length = 596 Score = 221 bits (563), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 156/567 (27%), Positives = 275/567 (48%), Gaps = 30/567 (5%) Query: 23 GSVTYINFSNAMEKKSSNFYWISLLETDRKLKFALSEITSITNSAITQPAIQQSLKQPDF 82 G ++Y N+ ++ K + N+ + L L ++ +++ + +QQ + + Sbjct: 38 GFISYQNYIQSINKNTKNYVTELISNMQANLDSHLEDMMTVSKIPLYSVEMQQYMSHQEM 97 Query: 83 VLTYDRKQEINNLLINHPMITSFSLYGKDR---LLYQYNAPMSFADM--RQQTWYGAMER 137 L R+ + L++ +S Y D + Y+ DM + W Sbjct: 98 TLEKQRQMDFYIGLLDSMRKNLYSAYLYDNYGNVFYRIKTDAIREDMMSHYEEWKRLAIE 157 Query: 138 AEGRPVWXXXXXXXXXXXXXXVLVQA-RIIKDYYSLEDIGYLVVYVKPDLLDQIFWEAAT 196 G PV L R I+D +LE IGY+ V +++ + E T Sbjct: 158 GNGNPVIIPTQRVMRANGTPQYLFTVLRSIRDIGTLETIGYVAVDADIHVIEDVVQELNT 217 Query: 197 LKKGDILLVNKQGNIVFNKSGEHIGQRTDFP---FLQENYNQEQDYYIDNYQGEKSLITF 253 + G L+++ Q N+ ++ +H+ T+ +Q + + + G + ++ Sbjct: 218 VTNGKTLIIDGQNNVAYDS--DHVLTATNITGNEVIQRAVGDQGSFNV-VVDGSSYICSY 274 Query: 254 LPSHNADWYLAAITPMNLISSESVSIRNIAL-----ILG---AVSLISAFLFDHYFIRRL 305 S + W + A P++ + ++ RN+ L I+G VS+I AF+ + Sbjct: 275 SVSKDTGWKIFAFVPVDYLHHDAQLTRNVTLTTTIGIIGFALLVSVILAFM--------M 326 Query: 306 VRSINSAVNGMKRVKQGIFTPINVPARADDESDSLIDGFNRMSSQISELIEQVQTEQGRK 365 RS+ + M+ V+ G ++ + DE L FNRM ++ ELI ++ Q RK Sbjct: 327 TRSLRQMTDLMRTVRGGNL-DVSFDVKQKDEVGILGTEFNRMLRRMKELISEIYVIQSRK 385 Query: 366 KEAEMQALMAQINPHFIYNSLESINSMAVLAGNRDISKMVVSLGRLLRISISQNQELIPL 425 KEA+++AL +QINPHFIYN+LE+I A + + ++++M +LG+LLR SI++ +E + L Sbjct: 386 KEADLEALQSQINPHFIYNTLETIRMTAEINDDEEVAEMTFTLGKLLRYSINRGRETVEL 445 Query: 426 QMEFEHVRHYLDIQKFRFEDKFSYALELPASLKNLMTQKLIVQPIVENALYHAIEQMEEH 485 + E +H+ YL + ++RF ++F A ++P L N KL QPIVENA+ H +E Sbjct: 446 REELQHLERYLQLLRYRFSNRFVVAFDIPQELMNFPVMKLTFQPIVENAILHGMEGKPNE 505 Query: 486 GVITISAEETGKDLIIIVKDNGPGFELATLMSLWNE-ERTNPKKYSDSGVGLKNVHERLN 544 I +SAE + LI +KD G G + TL L T S +GVGL+NV+ER+ Sbjct: 506 VTIRLSAELKEQLLIFSIKDEGAGMDGMTLDLLRQAMNGTRESASSKTGVGLRNVNERIK 565 Query: 545 IRFGNPYGIVVCSSPGFGSTICIRIPR 571 + +G YG+ + S G G+T+ +++PR Sbjct: 566 LHYGETYGLEIESKWGEGTTVNLKLPR 592 >Q8R7Q4.1 Q8R7Q4_THETN Predicted ATPase Length = 593 Score = 217 bits (552), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 159/586 (27%), Positives = 296/586 (50%), Gaps = 41/586 (6%) Query: 12 ILLVFIPVIVMGSVTYINFS-----NAMEKKSSNFYWISLLETDRKL----KFALSEITS 62 IL++F ++V+ S+ + FS N ++K+ N SLL +++ F ++ Sbjct: 18 ILILFYGIVVITSLLIVFFSYTISINQLKKEVGN----SLLRDTKRIAASIDFLQRDVNE 73 Query: 63 ITNSAITQPAIQQSLKQPDFVLTYDRKQEINNLLINHPMITSFSLYG--KDRLLYQYNAP 120 +++ + IQ + P T + +LL + I+ +LY D+ + ++ Sbjct: 74 LSSFLVLDQRIQNFI-SPHSDFTKYSLGPLASLLASKDYISFIALYSFQGDKYYFSNDSS 132 Query: 121 MSFADM---RQQTWYGAMERAEGRPVWXXXXXX---XXXXXXXXVLVQARIIKDYYSLED 174 D+ ++ ++Y + G P+W + AR++ D+ + + Sbjct: 133 TLIMDLELIKRTSFYREVLEKNGAPMWLSLENLPFDLIIKNNYPKIAMARVLLDFNTYKP 192 Query: 175 IGYLVVYVKPDLLDQIFWEAATLKKGDILLVNKQGNIV-FNKSGEHIGQRTDFPFLQENY 233 G LV+ + +++++ E K+ + ++ GNI+ F + ++ L + Sbjct: 193 EGLLVICINIPTIEKVYSENLKEKESAFFIADRNGNIISFKSTFSGFTPKSAQNILAKYL 252 Query: 234 NQEQDYYIDNYQGEKSLITFLPSHNADWYLAAITPM-NLISSESVSIRNIALILGAVSLI 292 +Q+ I N K L+T P +DW L ++ + N I+S +S L + L+ Sbjct: 253 KDKQNVVI-NINSSKLLVTSSPIPTSDWRLVSVVSLKNAINSIRISFIEFYLRILVFCLL 311 Query: 293 SAFLFDHYFIRRLVRSINSAVNGMKRVKQG-IFTPINVPARADDESDSLIDGFNRMSSQI 351 AFL YF R L + N MK+V+QG + + + DE +I +NRM +I Sbjct: 312 FAFLVSMYFSRALTHPLERLANSMKKVRQGNLEEKVEFEYHSKDEIAIVIKEYNRMVERI 371 Query: 352 SELIEQVQTEQGRKKEAEMQALMAQINPHFIYNSLESINSMAVLAGNRDISKMVVSLGRL 411 ++LI ++ + K+EAE++AL AQINPHF+YN+L++I A A +R++S+M+ SL RL Sbjct: 372 NDLINRILKLEINKREAELKALEAQINPHFLYNTLDTIFWKAEKAKDRELSEMIYSLSRL 431 Query: 412 LRISISQNQELIPLQMEFEHVRHYLDIQKFRFEDKFSYALELPASLKNLMTQKLIVQPIV 471 R+++++ +E I ++ E E + YL +Q R+++KF Y++++ + + KLI+QP V Sbjct: 432 FRLTLNRGEEFIQVRGEKELIERYLFLQSKRYKNKFKYSVKISDEILDYYIPKLILQPFV 491 Query: 472 ENALYHAIEQMEEHGVITISAEETGKDLIIIVKDNGPGFELATLMSLWNEERTNPKKYSD 531 ENA+ H +E E + + E+ G++L I+KDNGPG TL L K++ + Sbjct: 492 ENAIVHGLENNSEESFVEVIGEKEGENLKFIIKDNGPGMSEETLEKL--------KRFIE 543 Query: 532 S-------GVGLKNVHERLNIRFGNPYGIVVCSSPGFGSTICIRIP 570 S G ++NV+ERL + +G+ Y + + S G G+TI + +P Sbjct: 544 SENIEEKVGYAIRNVNERLRLYYGDKYELKIESRQGEGTTISLILP 589 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.321 0.137 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,107,783,356 Number of extensions: 124300742 Number of successful extensions: 388899 Number of sequences better than 1.0e-05: 2179 Number of HSP's gapped: 386237 Number of HSP's successfully gapped: 2179 Length of query: 574 Length of database: 3,060,696,203 Length adjustment: 141 Effective length of query: 433 Effective length of database: 1,732,333,088 Effective search space: 750100227104 Effective search space used: 750100227104 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 134 (56.2 bits)