BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0565.0005.p (882 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KHG9.1 B3KHG9_9BACI Ribonucleoside-diphosphate reductase, aden... 1370 0.0 B1DBN2.1 B1DBN2_9BACL Ribonucleoside-diphosphate reductase, aden... 1264 0.0 C0UU90.1 C0UU90_9BACT Ribonucleoside-diphosphate reductase, aden... 617 e-174 B7R7T8.1 B7R7T8_9THEO Ribonucleoside-diphosphate reductase EC=1.... 588 e-166 Q8R7R2.1 Q8R7R2_THETN Ribonucleoside-diphosphate reductase EC=1.... 578 e-162 >B3KHG9.1 B3KHG9_9BACI Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent Length = 883 Score = 1370 bits (3547), Expect = 0.0, Method: Compositional matrix adjust. Identities = 685/894 (76%), Positives = 726/894 (81%), Gaps = 31/894 (3%) Query: 3 RKQRLEGLSEKIFLDRYAWKDADSNNAKVGDVVLVLTKDDPKFPTKEVGEIVERTGRIVT 62 + QRLEGLSEKIFLDRYAWKDAD+NNAKVGDVVLVLTKDDPKFPTKEVGEIV+R GR VT Sbjct: 5 QNQRLEGLSEKIFLDRYAWKDADTNNAKVGDVVLVLTKDDPKFPTKEVGEIVKREGRKVT 64 Query: 63 VKTRSGELVESDVEKLTLNIEKTPEEMWDRLASAMASVESTPELQEEWTGKFRSILDDWK 122 VKTR GELVESDVEKLTL IEKTPEEMWDRLA+AM+SVE+TPELQEEW GKFR ILDDWK Sbjct: 65 VKTRKGELVESDVEKLTLTIEKTPEEMWDRLAAAMSSVEATPELQEEWRGKFREILDDWK 124 Query: 123 LVPGGRIAAGAGASEELTLFNCYVVPSPKDSRGGIMQTLSEMTEIMARGGGVGINLSSLR 182 LVPGGRIAAGAGAS+ELTLFNCYV+PSPKDSRGGIM+TLSEMTEIMARGGGVGINLSSLR Sbjct: 125 LVPGGRIAAGAGASDELTLFNCYVIPSPKDSRGGIMETLSEMTEIMARGGGVGINLSSLR 184 Query: 183 PRRAIVRXXXXXXXXXXXXXXLFSYTTGLIEQGGSRRGALMLMINDWHPDVVDFITVKQT 242 PRRAIVR LFSYTTGLIEQGGSRRGALMLM+NDWHPDV DFITVKQT Sbjct: 185 PRRAIVRGVNGSSSGAVSWGGLFSYTTGLIEQGGSRRGALMLMMNDWHPDVEDFITVKQT 244 Query: 243 MGQVTNANLSVCVSNSFMKAVKEDLDWELVFPDTTDPDYDAVWDGDLDKWKADGRAVIPY 302 MGQVTNANLSVCVSN FMKAVKEDLDWELVFPDTTDPDYD +WDGDLDKWK GR +IPY Sbjct: 245 MGQVTNANLSVCVSNDFMKAVKEDLDWELVFPDTTDPDYDELWDGDLDKWKKAGRRIIPY 304 Query: 303 RTVKARDVWHTIIESAWKSAEPGVVFMEYYNQMSNSWYFNPIICTNPCGEQGLPGWGVCN 362 +TVKAR+VWHTIIESAWKSAEPGVVFMEYYNQMSNSWYFNPIICTNPCGEQGLPGWGVCN Sbjct: 305 KTVKAREVWHTIIESAWKSAEPGVVFMEYYNQMSNSWYFNPIICTNPCGEQGLPGWGVCN 364 Query: 363 LSAVNLSKFYDAENHDVDWADLATTTRYSVRFLDNVIDKTPYHFPENEANQRKERRVGLG 422 LSA+NLSKFYD NHDV W +LATTTRYSVRFLDNVID+TPYHF ENE NQ+KERRVGLG Sbjct: 365 LSAMNLSKFYDEANHDVAWDELATTTRYSVRFLDNVIDRTPYHFEENELNQKKERRVGLG 424 Query: 423 TMGLAELMIKLNIRYGSPESLEFLDKLYGXXXXYGFMAREAYLASSEIAGEKGSFQAFDT 482 TMGLAELMIKLNIRYGSPESLEFLDKL YGF+AREAYLAS++IA EKGSFQAFD Sbjct: 425 TMGLAELMIKLNIRYGSPESLEFLDKL------YGFIAREAYLASADIAEEKGSFQAFDA 478 Query: 483 EKYLLSGFMKNITETYPEVGEAIRKNGMRNVTVITQAPXXXXXXXXXXXXXIEPYFAFKY 542 E YL SGFMKN+ E YPEV EA+RK G RNVTVITQAP IEPYFAFKY Sbjct: 479 ELYLQSGFMKNMAEVYPEVAEAVRKKGARNVTVITQAPTGSTGTMVGTSTGIEPYFAFKY 538 Query: 543 FRQSRLGYDEQFVPIAQEWLEAHPGEELPDYFVTSMDLSAKDHIRAQAAIQRWVDSSISK 602 FRQSRLG+DEQFVPIAQ+WL++HPGEELPDY+VT+M LSA+DHIR QAAIQRWVDSSISK Sbjct: 539 FRQSRLGFDEQFVPIAQDWLDSHPGEELPDYYVTAMSLSAEDHIRVQAAIQRWVDSSISK 598 Query: 603 TANCPSDFTVEETAELYEMAFDLGCKGVTIYRDGSRDVQVLETSKKEDKK---------- 652 TANCPSDFTVE+T LYE+AFDLGCKGVTIYRDGSRDVQVL+T KKEDK Sbjct: 599 TANCPSDFTVEDTKRLYELAFDLGCKGVTIYRDGSRDVQVLQTEKKEDKAAEATTASTAE 658 Query: 653 ---DXXXXXXXXXXXXXXXXXXXXXXXXXXXQGSAVDKQYKKRPQVLRGATYKINTPFGM 709 + S +DKQYKKRPQVLRGATYK+NTPFGM Sbjct: 659 AALEQSAAGQAAEETASVEPAAASVVVTASPSKSGLDKQYKKRPQVLRGATYKMNTPFGM 718 Query: 710 AYITINDLDGIPAEIFLNVGKAGSDVFAMAEALGRVCSLFLRYGDHGEKVELLIKHLKXX 769 AYITINDLDGIP+EIFLNVGKAGSDVFAMAEALGRVCSLFLRYGDHG KVELLIKHLK Sbjct: 719 AYITINDLDGIPSEIFLNVGKAGSDVFAMAEALGRVCSLFLRYGDHGNKVELLIKHLKGI 778 Query: 770 XXXXXXXXXXNRVESIADAVAKALETHVLNNAH--DDHVPAPIAATLELDFNEALSAELK 827 NRVESIADAVAKALETHV NNA DH PAP+AAT+ A Sbjct: 779 GGTGAIGFGANRVESIADAVAKALETHVANNAEADHDHDPAPVAATMAPADAGEGGATAA 838 Query: 828 SSVPAAAXXXXXXXXXXXXXXXXXXRDLCPSCGSASLINIEGCKTCSNCGYSRC 881 + DLCPSCG ASLINIEGCKTC NCGYS+C Sbjct: 839 AGHGGHGAHAGGSMSL----------DLCPSCGGASLINIEGCKTCGNCGYSKC 882 >B1DBN2.1 B1DBN2_9BACL Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent Length = 864 Score = 1264 bits (3272), Expect = 0.0, Method: Compositional matrix adjust. Identities = 635/882 (71%), Positives = 690/882 (78%), Gaps = 28/882 (3%) Query: 5 QRLEGLSEKIFLDRYAWKDADSNNAKVGDVVLVLTKDDPKFPTKEVGEIVERTGRIVTVK 64 Q+LEGLSEKIFLDRYAWK+AD+ N VGDVVLVLTKDDPKFP KEVGE+ R+G VTVK Sbjct: 5 QKLEGLSEKIFLDRYAWKNADTKNTAVGDVVLVLTKDDPKFPAKEVGEVTGRSGDEVTVK 64 Query: 65 TRSGELVESDVEKLTLNIEKTPEEMWDRLASAMASVESTPELQEEWTGKFRSILDDWKLV 124 RSG+ V S VEKLTL IEKTPEEMW+RLA AMA VE E + WT +FR ILDDWKLV Sbjct: 65 LRSGDTVTSSVEKLTLTIEKTPEEMWNRLAGAMAGVEQGEEKRRTWTERFRYILDDWKLV 124 Query: 125 PGGRIAAGAGASEELTLFNCYVVPSPKDSRGGIMQTLSEMTEIMARGGGVGINLSSLRPR 184 PGGRIAAGAGAS+ELTLFNCYV+PSPKDSRGGIM TLSEMTEIMARGGGVGINLSSLRPR Sbjct: 125 PGGRIAAGAGASDELTLFNCYVIPSPKDSRGGIMTTLSEMTEIMARGGGVGINLSSLRPR 184 Query: 185 RAIVRXXXXXXXXXXXXXXLFSYTTGLIEQGGSRRGALMLMINDWHPDVVDFITVKQTMG 244 RA+V LFSYTTGLIEQGGSRRGALMLMINDWHPDV+DFITVKQTMG Sbjct: 185 RAVVAGVNGSSSGAVSWGGLFSYTTGLIEQGGSRRGALMLMINDWHPDVLDFITVKQTMG 244 Query: 245 QVTNANLSVCVSNSFMKAVKEDLDWELVFPDTTDPDYDAVWDGDLDKWKADGRAVIPYRT 304 QVTNANLSVCVSN+FMKAVKEDLDWELVFPDT + DYD +WDGDL+ WK G+ V+ Y+T Sbjct: 245 QVTNANLSVCVSNAFMKAVKEDLDWELVFPDTKETDYDELWDGDLEAWKKLGKKVVHYKT 304 Query: 305 VKARDVWHTIIESAWKSAEPGVVFMEYYNQMSNSWYFNPIICTNPCGEQGLPGWGVCNLS 364 V+ARDVWHTIIESAWKSAEPGVVFMEYYNQMSNSWYFNPIICTNPCGEQGLPGWGVCNLS Sbjct: 305 VRARDVWHTIIESAWKSAEPGVVFMEYYNQMSNSWYFNPIICTNPCGEQGLPGWGVCNLS 364 Query: 365 AVNLSKFYDAENHDVDWADLATTTRYSVRFLDNVIDKTPYHFPENEANQRKERRVGLGTM 424 A+NLSKFYD HDV+W +L T++SVRFLDNVID TPYHF ENE NQ+KERRVGLGTM Sbjct: 365 AINLSKFYDESKHDVNWEELGKVTQWSVRFLDNVIDTTPYHFEENEKNQKKERRVGLGTM 424 Query: 425 GLAELMIKLNIRYGSPESLEFLDKLYGXXXXYGFMAREAYLASSEIAGEKGSFQAFDTEK 484 GLAELMIKL +RYGSPESL FLDK+ YGFMAREAYLAS+EIA EKGSF+AFD EK Sbjct: 425 GLAELMIKLGVRYGSPESLLFLDKI------YGFMAREAYLASAEIASEKGSFEAFDAEK 478 Query: 485 YLLSGFMKNITETYPEVGEAIRKNGMRNVTVITQAPXXXXXXXXXXXXXIEPYFAFKYFR 544 +L SGFMKN+ +PEVGEA+ GMRNVTVITQAP IEPYFAF+YFR Sbjct: 479 FLQSGFMKNMVSEFPEVGEAVLAKGMRNVTVITQAPTGSTGTMVGTSTGIEPYFAFEYFR 538 Query: 545 QSRLGYDEQFVPIAQEWLEAHPGEELPDYFVTSMDLSAKDHIRAQAAIQRWVDSSISKTA 604 QSRLG+D+Q VPIAQ W +AHPGEELPDYFVT+M+LSAKDHIR QAAIQRWVDSSISKTA Sbjct: 539 QSRLGFDKQLVPIAQAWKDAHPGEELPDYFVTAMNLSAKDHIRVQAAIQRWVDSSISKTA 598 Query: 605 NCPSDFTVEETAELYEMAFDLGCKGVTIYRDGSRDVQVLETSKKEDKKDXXXXXXXXXXX 664 NCPSDFTVEET ELYEMAFDLGCKGVTIYRDGSRDVQVL T K ++K D Sbjct: 599 NCPSDFTVEETKELYEMAFDLGCKGVTIYRDGSRDVQVLSTKKDDEKPDAAGEAAAAAEA 658 Query: 665 XXXXXXXXXXXXXXXXQGSA-----VDKQYKKRPQVLRGATYKINTPFGMAYITINDLDG 719 + S DKQYK+RPQ+LRGATYK+NTPFGMAYITINDL+G Sbjct: 659 VKEEDKLENLNTTLNAKESPQVEQEFDKQYKRRPQILRGATYKVNTPFGMAYITINDLNG 718 Query: 720 IPAEIFLNVGKAGSDVFAMAEALGRVCSLFLRYGDHGEKVELLIKHLKXXXXXXXXXXXX 779 IP EIFLNVGKAGSDVFAMAEALGRVCSLFLRYGDHG KV+LLIKHLK Sbjct: 719 IPGEIFLNVGKAGSDVFAMAEALGRVCSLFLRYGDHGNKVKLLIKHLKGIGGTGAIGFGA 778 Query: 780 NRVESIADAVAKALETHVLNNAHDDHVPAPIAATLELDFNEALSAELKSSVPAAAXXXXX 839 NRVESIADAVAKALE H+ + P+ A + F A +AE Sbjct: 779 NRVESIADAVAKALEIHIESTNEQAAAYEPVKAASAVAFAAAPAAE-------------- 824 Query: 840 XXXXXXXXXXXXXRDLCPSCGSASLINIEGCKTCSNCGYSRC 881 RDLCPSCGSASLINIEGCK CSNCGYS+C Sbjct: 825 ---DSHKHGEVTSRDLCPSCGSASLINIEGCKQCSNCGYSKC 863 >C0UU90.1 C0UU90_9BACT Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent Length = 811 Score = 617 bits (1592), Expect = e-174, Method: Compositional matrix adjust. Identities = 346/821 (42%), Positives = 467/821 (56%), Gaps = 86/821 (10%) Query: 82 IEKTPEEMWDRLASAMASVESTPELQEEWTGKFRSILDDWKLVPGGRIAAGAGASEELTL 141 +E PEEMW R+A A+A+VE PE Q +WT +F IL ++ VPGGRI +GAG+ E+T Sbjct: 56 LEHYPEEMWLRVAKAIAAVEPNPEAQRQWTLRFYDILQGFRFVPGGRILSGAGSGAEVTY 115 Query: 142 FNCYVVPSPKDSRGGIMQTLSEMTEIMARGGGVGINLSSLRPRRAIVRXXXXXXXXXXXX 201 +NC+V+PSP+DS GI + ++ IM R GGVG+NLSSLRPR A ++ Sbjct: 116 YNCFVIPSPEDSVEGIFRNITTAAHIMRRSGGVGVNLSSLRPRGAYIKTVNGTSSGPCSW 175 Query: 202 XXLFSYTTG-LIEQGGSRRGALMLMINDWHPDVVDFITVK-QTMGQVTNANLSVCVSNSF 259 L+S TG +I QGGSRRGALM+M++D HPD+ +F+ K + G + +ANLSV VS++F Sbjct: 176 AILYSDMTGKVIIQGGSRRGALMIMLDDDHPDIEEFVEYKRKNPGHIDHANLSVAVSDAF 235 Query: 260 MKAVKEDLDWELVFPDTTDPDYDAVWDGDLDKWKADGRAVIPYRTVKARDVWHTIIESAW 319 M+AVK+DL W+L W G + WK T++ARD+W I ESAW Sbjct: 236 MEAVKKDLPWDLK------------WQGKV--WK----------TIRARDLWRKIAESAW 271 Query: 320 KSAEPGVVFMEYYNQMSNSWYFNPIICTNPCGEQGLPGWGVCNLSAVNLSKFY---DAEN 376 AEPG+VF++ YN+ SN+WYF I C NPCGEQGLP WGVCNL A+NL F D E Sbjct: 272 AYAEPGLVFIDRYNKRSNTWYFENIRCVNPCGEQGLPPWGVCNLGALNLLAFVKHIDGET 331 Query: 377 HDVDWADLATTTRYSVRFLDNVIDKTPYHFPENEANQRK-ERRVGLGTMGLAELMIKLNI 435 + D+ DLA T R ++RFLDNVID T Y FPENE Q+ RR GLGTMGLA+++IKL + Sbjct: 332 Y-FDFEDLANTARVAIRFLDNVIDATVYPFPENEEAQKHGARRTGLGTMGLADVLIKLGV 390 Query: 436 RYGSPESLEFLDKLYGXXXXYGFMAREAYLASSEIAGEKGSFQAFDTEKYLLSGFMKNIT 495 +YGSPE+ ++++Y + AY AS+++A EKG F FD +KY+ F++ + Sbjct: 391 KYGSPEAEPLVERIYRT------IRDAAYDASADLAAEKGPFPKFDRDKYMQGEFIRELP 444 Query: 496 ETYPEVGEAIRKNGMRNVTVITQAPXXXXXXXXXXXXXIEPYFAFKYFRQSRLGYDEQFV 555 E E+ IR+ G+RN ++TQAP IEP FAF R+ RLG + Sbjct: 445 E---EIQAKIRRQGIRNAVLLTQAPTGTTSSLAGVNSGIEPVFAFVTKRRDRLGEHLLYH 501 Query: 556 PIAQEWLEAHPGEELPDYFVTSMDLSAKDHIRAQAAIQRWVDSSISKTANCPSDFTVEET 615 P+AQEW++AHPG+ LPDYFV+S DL+ ++HIR QA +Q++ DSSISKT N P D TVE+ Sbjct: 502 PLAQEWMDAHPGKPLPDYFVSSADLTPEEHIRIQAVVQKYTDSSISKTVNGPEDNTVEDV 561 Query: 616 AELYEMAFDLGCKGVTIYRDGSRD--VQVLETSKKEDKKDXXXXXXXXXXXXXXXXXXXX 673 LY +A+D GCKG+T YR GSRD ++ ++T KE + Sbjct: 562 ERLYMLAYDTGCKGITYYRQGSRDAVLEAVDTKPKEKAEKPEEAPKASHPEVHRST---- 617 Query: 674 XXXXXXXQGSAVDKQYKKRPQVLRGATYKINTPFGMAYITINDLDGIPAEIFLNVGKAGS 733 KKRP V+ G T +I P G IT+N D E+F+N+GKAGS Sbjct: 618 ---------------LKKRPDVVSGYTRQIRAPEGKVNITLNSDDEGLLEVFINLGKAGS 662 Query: 734 DVFAMAEALGRVCSLFLRYG---DHGEKVELLIKHLKXXXXXXXXXXXXNRVESIADAVA 790 D+ AMAEALGR+ S L+ E+ + L+ +V+S+ DAV Sbjct: 663 DIAAMAEALGRLISFALQMPSPMSPNERAAEIADQLRGIGGSRSVGFGPGQVKSLPDAVG 722 Query: 791 KALETHVLN----------NAHDDHVPAPIAATLELDFNEALSAELKSSVPAAAXXXXXX 840 +AL H+ + N H D + A + + N E S+ Sbjct: 723 QALLKHLQSEGIALSNGNGNGHADVESKELVAVVAQNGNHG--EETPESI---------- 770 Query: 841 XXXXXXXXXXXXRDLCPSCGSASLINIEGCKTCSNCGYSRC 881 +LCPSCG SLI EGCK C CGYS C Sbjct: 771 AQKLLEKTYQLTGNLCPSCGCNSLIAQEGCKKCYTCGYSEC 811 >B7R7T8.1 B7R7T8_9THEO Ribonucleoside-diphosphate reductase EC=1.17.4.1 Length = 724 Score = 588 bits (1517), Expect = e-166, Method: Compositional matrix adjust. Identities = 322/807 (39%), Positives = 461/807 (57%), Gaps = 116/807 (14%) Query: 82 IEKTPEEMWDRLASAMASVESTPELQEEWTGKFRSILDDWKLVPGGRIAAGAGASEELTL 141 +EK PEEM+ R+A A+A+ E E+ F ++ +WK +PGGRI AGAG E+T Sbjct: 27 VEKKPEEMFKRVAKAIATNEKEEEM-------FYKVMSEWKFIPGGRILAGAGTGREVTY 79 Query: 142 FNCYVVP----SPK---DSRGGIMQTLSEMTEIMARGGGVGINLSSLRPRRAIVRXXXXX 194 FNC+V+P PK DSR IM T+++M EI +RGGGVGIN S+LRPR A V+ Sbjct: 80 FNCFVIPVEANDPKKGNDSRAAIMDTIAKMLEINSRGGGVGINWSTLRPRGAYVKGVGGT 139 Query: 195 XXXXXXXXXLFSYTTGLIEQGGSRRGALMLMINDWHPDVVDFITVKQTMGQVTNANLSVC 254 + +EQGGSRR ALM M+ DWHPD+ +FI VK+ + ++ ANLSV Sbjct: 140 SSGAVSWMLAANEVATQVEQGGSRRAALMFMLWDWHPDIEEFIKVKKDLTKMQQANLSVA 199 Query: 255 VSNSFMKAVKEDLDWELVFPDTTDPDYDAVWDGDLDKWKADGRAVIPYRTVKARDVWHTI 314 VS++FM+AV +D W+L FPDT+ P+YDA W GDL++WKA G + Y+ + AR++W+ I Sbjct: 200 VSDAFMEAVAQDKMWKLEFPDTSHPNYDAEWKGDLNEWKAKGYPTVVYKEIPARELWNKI 259 Query: 315 IESAWKSAEPGVVFMEYYNQMSNSWYFNPIICTNPCGEQGLPGWGVCNLSAVNLSKFYDA 374 + +AW+SAEPGVVF+E YN++SN++Y II TNPCGE GL +GVCNL A+NL F Sbjct: 260 VTAAWESAEPGVVFLERYNKLSNTYYITKIISTNPCGELGLEPYGVCNLGAINLVAF--V 317 Query: 375 ENHDVDWADLATTTRYSVRFLDNVIDKTPYHFPENEANQRKERRVGLGTMGLAELMIKLN 434 EN +++ +L T + +VRFLDNV+D Y P+N+ +K RRVGLG MGLA+ +I +N Sbjct: 318 ENGRINFEELEETVKIAVRFLDNVLDLGAYVLPQNKEMAQKLRRVGLGLMGLADALILMN 377 Query: 435 IRYGSPESLEFLDKLYGXXXXYGFMAREAYLASSEIAGEKGSFQAFDTEKYLLSGFMKNI 494 +RYGS ESL+ +++ + AY AS E+A EKG F F +KYL F++ + Sbjct: 378 LRYGSEESLKATEEIVKR------IRDAAYRASVELAKEKGPFPEFVADKYLKGQFIQRL 431 Query: 495 TETYPEVGEAIRKNGMRNVTVITQAPXXXXXXXXXXXXXIEPYFAFKYFRQSRLGYDEQF 554 + ++ + I K G+RN T++TQAP IEP FA +Y R+ R G Sbjct: 432 PK---DIRDEIAKYGIRNATILTQAPTGTTSILAGVSSGIEPNFAKEYVRKDRTG----- 483 Query: 555 VPIAQEWLEAHPGEELPDYFVTSMDLSAKDHIRAQAAIQRWVDSSISKTANCPSDFTVEE 614 + WL +P FV++ +++ ++H++ QA +Q+++DSSISKT N P TV++ Sbjct: 484 THTVKHWLADYPA------FVSAHEVTPEEHVKMQAVLQKYIDSSISKTINLPRTATVDD 537 Query: 615 TAELYEMAFDLGCKGVTIYRDGSRDVQVLETSKKEDKKDXXXXXXXXXXXXXXXXXXXXX 674 +Y +A++LGCKG+T+YRDGSR+ ++ +K ++K Sbjct: 538 IDNIYRLAYELGCKGITVYRDGSREGVLVTDTKPQEK----------------------- 574 Query: 675 XXXXXXQGSAVDKQYKKRPQVLRGATYKINTPFGMAYITINDLDGIPAEIFLNVGKAGSD 734 + +RP VL+G T +I TP G AY+TIN +D P E+F+N+G+AGSD Sbjct: 575 ------------TKITERPPVLKGITKRIETPLGRAYVTINFIDNKPFEVFVNIGRAGSD 622 Query: 735 VFAMAEALGRVCSLFLRYGDHGEKVELLIKHLKXXXXXXXXXXXXNRVESIADAVAKALE 794 V A EA+ R+ SL LR G VE +I+ L NRV S+ DA+ KAL Sbjct: 623 VAAFTEAIARLISLALR---GGVAVEDIIEQLVGIGGATTIGFGENRVLSVPDAIGKALR 679 Query: 795 THVLNNAHDDHVPAPIAATLELDFNEALSAELKSSVPAAAXXXXXXXXXXXXXXXXXXRD 854 N ++ +SV +A D Sbjct: 680 -----NGYEQQ---------------------GNSVKVSATNV----------------D 697 Query: 855 LCPSCGSASLINIEGCKTCSNCGYSRC 881 +CP CG A+ + EGCKTC NCGYS+C Sbjct: 698 ICPVCGMATFVYTEGCKTCLNCGYSQC 724 >Q8R7R2.1 Q8R7R2_THETN Ribonucleoside-diphosphate reductase EC=1.17.4.1 Length = 691 Score = 578 bits (1489), Expect = e-162, Method: Compositional matrix adjust. Identities = 317/800 (39%), Positives = 455/800 (56%), Gaps = 116/800 (14%) Query: 89 MWDRLASAMASVESTPELQEEWTGKFRSILDDWKLVPGGRIAAGAGASEELTLFNCYVVP 148 M+ R+A A+A+ E E+ F ++ +WK +PGGRI AGAG E+T FNC+V+P Sbjct: 1 MFKRVAKAIATNEKEEEM-------FYKVMSEWKFIPGGRILAGAGTGREVTYFNCFVIP 53 Query: 149 ----SPK---DSRGGIMQTLSEMTEIMARGGGVGINLSSLRPRRAIVRXXXXXXXXXXXX 201 PK DSR IM T+++M EI +RGGGVGIN S+LRPR A V+ Sbjct: 54 VEANDPKKGNDSRAAIMDTIAKMLEINSRGGGVGINWSTLRPRGAYVKGVGGTSSGAVSW 113 Query: 202 XXLFSYTTGLIEQGGSRRGALMLMINDWHPDVVDFITVKQTMGQVTNANLSVCVSNSFMK 261 + +EQGGSRR ALM M+ DWHPD+ +FI VK+ + ++ ANLSV VS++FM+ Sbjct: 114 MLAANEVATQVEQGGSRRAALMFMLWDWHPDIEEFIKVKKDLTKMQQANLSVAVSDAFME 173 Query: 262 AVKEDLDWELVFPDTTDPDYDAVWDGDLDKWKADGRAVIPYRTVKARDVWHTIIESAWKS 321 AV +D W+L FPDT+ P+YDA W GDL++WKA G + Y+ + AR++W+ I+ +AW+S Sbjct: 174 AVAQDKMWKLEFPDTSHPNYDAEWKGDLNEWKAKGYPTVVYKEIPARELWNKIVTAAWES 233 Query: 322 AEPGVVFMEYYNQMSNSWYFNPIICTNPCGEQGLPGWGVCNLSAVNLSKFYDAENHDVDW 381 AEPGVVF+E YN++SN++Y II TNPCGE GL +GVCNL A+NL F EN +++ Sbjct: 234 AEPGVVFLERYNKLSNTYYITKIISTNPCGELGLEPYGVCNLGAINLVAF--VENGKINF 291 Query: 382 ADLATTTRYSVRFLDNVIDKTPYHFPENEANQRKERRVGLGTMGLAELMIKLNIRYGSPE 441 +L T + +VRFLDNV+D Y P+N+ +K RRVGLG MGLA+ +I +N+RYGS E Sbjct: 292 EELEETVKIAVRFLDNVLDLGAYVLPQNKEMAQKLRRVGLGLMGLADALILMNLRYGSEE 351 Query: 442 SLEFLDKLYGXXXXYGFMAREAYLASSEIAGEKGSFQAFDTEKYLLSGFMKNITETYPEV 501 SL+ +++ + AY AS E+A EKG F F +KYL F++ + + ++ Sbjct: 352 SLKATEEIVRR------IRDAAYRASVELAKEKGPFPEFVADKYLKGQFIQRLPK---DI 402 Query: 502 GEAIRKNGMRNVTVITQAPXXXXXXXXXXXXXIEPYFAFKYFRQSRLGYDEQFVPIAQEW 561 + I K G+RN T++TQAP IEP FA +Y R+ R G + W Sbjct: 403 RDEIAKYGIRNATILTQAPTGTTSILAGVSSGIEPNFAKEYVRKDRTG-----THTVKHW 457 Query: 562 LEAHPGEELPDYFVTSMDLSAKDHIRAQAAIQRWVDSSISKTANCPSDFTVEETAELYEM 621 L +P FV++ +++ ++H++ QA +Q+++DSSISKT N P TV++ +Y + Sbjct: 458 LADYPA------FVSAHEVTPEEHVKMQAVLQKYIDSSISKTINLPRTATVDDIDNIYRL 511 Query: 622 AFDLGCKGVTIYRDGSRDVQVLETSKKEDKKDXXXXXXXXXXXXXXXXXXXXXXXXXXXQ 681 A++LGCKG+T+YRDGSR+ ++ +K ++K Sbjct: 512 AYELGCKGITVYRDGSREGVLVTDTKPQEK------------------------------ 541 Query: 682 GSAVDKQYKKRPQVLRGATYKINTPFGMAYITINDLDGIPAEIFLNVGKAGSDVFAMAEA 741 + +RP VL+G T +I TP G AY+TIN +D P E+F+N+G+AGSDV A EA Sbjct: 542 -----TKITERPPVLKGITKRIETPLGRAYVTINFIDNKPFEVFVNIGRAGSDVAAFTEA 596 Query: 742 LGRVCSLFLRYGDHGEKVELLIKHLKXXXXXXXXXXXXNRVESIADAVAKALETHVLNNA 801 + R+ SL LR G VE +I+ L NRV S+ DA+ KAL N Sbjct: 597 IARLISLALR---GGVAVEDIIEQLVGIGGATTIGFGENRVLSVPDAIGKALR-----NG 648 Query: 802 HDDHVPAPIAATLELDFNEALSAELKSSVPAAAXXXXXXXXXXXXXXXXXXRDLCPSCGS 861 ++ +SV +A D+CP CG Sbjct: 649 YEQQ---------------------GNSVKVSATNV----------------DICPVCGM 671 Query: 862 ASLINIEGCKTCSNCGYSRC 881 A+ + EGCKTC NCGYS+C Sbjct: 672 ATFVYTEGCKTCLNCGYSQC 691 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.317 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 4,718,894,720 Number of extensions: 183891368 Number of successful extensions: 469638 Number of sequences better than 1.0e-05: 2151 Number of HSP's gapped: 463240 Number of HSP's successfully gapped: 2629 Length of query: 882 Length of database: 3,060,696,203 Length adjustment: 145 Effective length of query: 737 Effective length of database: 1,694,649,028 Effective search space: 1248956333636 Effective search space used: 1248956333636 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 136 (57.0 bits)