BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0560.0026.p (2351 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value O30408.1 TYCB_BREPA Tyrocidine synthetase 2 ATP-dependent prolin... 1509 0.0 C0ZDA6.1 C0ZDA6_BREBN Tyrocidine synthetase II EC=5.1.1.11 1476 0.0 C0ZDA7.1 C0ZDA7_BREBN Tyrocidine synthetase III 1450 0.0 O30409.1 TYCC_BREPA Tyrocidine synthetase 3 ATP-dependent aspara... 1442 0.0 P0C064.2 GRSB_BREBE Gramicidin S synthetase 2 ATP-dependent prol... 1364 0.0 >O30408.1 TYCB_BREPA Tyrocidine synthetase 2 ATP-dependent proline adenylase ATP-dependent phenylalanine adenylase ATP-dependent D-phenylalanine adenylase Phenylalanine racemase [ATP-hydrolyzing] EC=5.1.1.11 Length = 3587 Score = 1509 bits (3906), Expect = 0.0, Method: Compositional matrix adjust. Identities = 785/1888 (41%), Positives = 1167/1888 (61%), Gaps = 39/1888 (2%) Query: 14 TSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQHLSNR 72 T++ +K++KYWL+R G + D P + EG+ L L + LQ ++ + Sbjct: 1232 TTDYQKQEKYWLDRFAGEIPVLNLPMDYPRPAVQSFEGERYL-FRTEKQLLESLQDVAQK 1290 Query: 73 SDDSLYYILLTALKWLIVKHTESSIITV----ASPVYMDENSTSEAYNHYVPIIDTFTTG 128 + +LY +LL A L+ K++ + + A V+ D S + + + + + + Sbjct: 1291 TGTTLYMVLLAAYHVLLSKYSGQDDVMIGTVTAGRVHPDTESMTGMFVNTLAMRNQSAPT 1350 Query: 129 MTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHND---- 184 TFR+ LL+V++ TL A++H YPF++++E + +R + + L +L N+ D Sbjct: 1351 KTFRQFLLEVKDNTLAAFEHGQYPFEELVEKLAIQRNRSRNPLFDTLFILQNMDADLIEL 1410 Query: 185 ---AVIPDVGSNIVFGF------TRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQILKGA 235 V P V V F + + AG+S + K F R + +++ Y QIL+ Sbjct: 1411 DGLTVTPYVPEGEVAKFDLSLEASENQAGLSFCFEFCTKLFARETIERMSLHYLQILQAV 1470 Query: 236 AENVSIKLGS--MXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQVRQTPDHVAVKFN 293 + N +L M T E TL +LFE Q ++TP+ AV F Sbjct: 1471 SANTEQELAQIEMLTAHEKQELLVHFNDTAALYPAES-TLSQLFEDQAQKTPEQTAVVFG 1529 Query: 294 NQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLPLDI 353 ++ +TYR+LN +AN+LA LR +GV A Q VG++ +RS++MA GI+ ILK+G AY+P+D Sbjct: 1530 DKRLTYRELNERANQLAHTLRAKGVQAEQSVGIMAQRSLEMAIGIIAILKAGGAYVPIDP 1589 Query: 354 KSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDLILGRALD 413 P ER+ +++ED + ++ +Q EK+ + + + LD++ +++ + A D Sbjct: 1590 DYPNERIAYMLEDCR-RLVLTQQQLAEKMTAN-VECLYLDEEGSYSPQTENIEPIHTAAD 1647 Query: 414 HPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDGFLTSFF 473 AY+IYTSGTTG+PKGV++EHR I N++ W + E++ D S+ FD F +FF Sbjct: 1648 L-AYIIYTSGTTGRPKGVMVEHRGIVNSVTWNRDEFALSVRDSGTLSLSFAFDAFALTFF 1706 Query: 474 TPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEAQSLRIV 533 T IVSG+TVV + + EA+DP+A+ LI + ++ + VP+++ A+L P + +S++ V Sbjct: 1707 TLIVSGSTVVLMPDHEAKDPIALRNLIAAWECSYVVFVPSMFQAILECSTPADIRSIQAV 1766 Query: 534 TLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELTIGKPIGNTR 593 L GEK++P L+ K +HP M ++N YGPTESSV+AT RD +PD +TIG+PI NT Sbjct: 1767 MLGGEKLSPKLVQLCKAMHPQMSVMNAYGPTESSVMATYLRDTQPDQP-ITIGRPIANTA 1825 Query: 594 VYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERMYRTGDLAR 653 +YIV + +L G+VGE+CI G GLARGY LT +KFV+NP ERMY+TGDL R Sbjct: 1826 IYIVDQHHQLLPVGVVGEICIGGHGLARGYWKKPELTAEKFVANPAVPGERMYKTGDLGR 1885 Query: 654 WTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNSRICAYI 713 W G I+ IGR D Q+K+RGYRIE+GEIE LL Y+ EA+V ++D +S + AY+ Sbjct: 1886 WLHDGTIDFIGRVDDQIKVRGYRIEVGEIEAVLLAYDQTNEAIVVAYQDDRGDSYLAAYV 1945 Query: 714 VCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLKELGARF 773 + ELR L + LP YM+PT+ QL+ FP+TP GK+DR AL + GA + Sbjct: 1946 TGKTAIEESELRAHLLRELPAYMVPTYLIQLDAFPLTPNGKVDRKALPKPEGKPATGAAY 2005 Query: 774 QHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVEIELDEI 833 P E+E++LV IW+N L + V + D+FF LGGHSLKA +++++H+EFQ+++ L + Sbjct: 2006 VAPATEVEAKLVAIWENALGISGVGVLDHFFELGGHSLKAMTVVAQVHREFQIDLLLKQF 2065 Query: 834 FEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGESTSYNMPEV 893 F TI +LA LI+ ++I P E + YYP+SSAQ+RMY L+ LEG SYN P + Sbjct: 2066 FAAPTIRDLARLIEHSEQAAGAAIQPAEPQAYYPVSSAQQRMYLLHQLEGAGISYNTPGI 2125 Query: 894 MVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYT---EEKID 950 +++EG+LD Q+ + L+ ++ RH+ILRTSF M+ E VQ +HD + +++Y E++ID Sbjct: 2126 IMLEGKLDREQLANALQALVDRHDILRTSFEMVGDELVQKIHDRVAVNMEYVTAEEQQID 2185 Query: 951 DIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLY 1010 D+ F++PFDL PL R+ ++K+A +L ++DMHHI +D SI + ELA LY Sbjct: 2186 DL---FHAFVRPFDLSVPPLLRMSLVKLADERHLLLYDMHHIAADAASITILFDELAELY 2242 Query: 1011 GNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSY 1070 LPE IQ+KDF+VW+K E+ FKQQE +WL F G + +++P D+ RP KS+ Sbjct: 2243 QGRELPEMRIQYKDFAVWQKALHESDAFKQQEAYWLSTFAGNITAVDVPTDFPRPAVKSF 2302 Query: 1071 EGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQ 1130 G ++ ++D+E L ELA TL+M+LLA +N++L+K Q+DIIVG+P++ R + Sbjct: 2303 AGGQVTLSMDQELLSALHELAAHTNTTLFMVLLAAYNVLLAKYAGQDDIIVGTPISGRSR 2362 Query: 1131 VELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRD 1190 EL V+GMF +TLA+RN P K FK FL EVK +AL AFD+QDY FE ++ KL I RD Sbjct: 2363 AELAPVVGMFVHTLAIRNKPTAEKTFKQFLQEVKQNALDAFDHQDYPFESLVEKLGIPRD 2422 Query: 1191 TGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEH--NISRFDITLHCLEGLDGLLHCSF 1248 GRNPLFD M ILQN ++ ++ YE + ++++FD++ H E L Sbjct: 2423 PGRNPLFDTMFILQNDELHAKTLDQLVYRPYESDSALDVAKFDLSFHLTERETDLF-LRL 2481 Query: 1249 EYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSFDLP 1307 EYCT+LFK++TVE M + I+ V A+ E + +I M++ Q +L AFN T + Sbjct: 2482 EYCTKLFKQQTVERMAHHFLQILRAVTANPENELQEIEMLTAAEKQMLLVAFNDTHREYR 2541 Query: 1308 ADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMF 1367 ADQTI LFEE A++ + AL F ++ MS+ ELN+RANQLA +LREKGV +V L+ Sbjct: 2542 ADQTIQQLFEELAEKMPEHTALVFEEKRMSFRELNERANQLAAVLREKGVGPAQIVALLV 2601 Query: 1368 ERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEV 1427 ERS EM+I L LK+GGA+LP+DPDYP ERI++M+EDS +LV+T + + EV Sbjct: 2602 ERSAEMVIATLATLKAGGAFLPVDPDYPEERIRYMLEDSQAKLVVTHAHLLHKVSSQSEV 2661 Query: 1428 IDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLK 1487 +D++ G NLP N SDLAY+IYTSGTTGKPKG +LEHKG+ NL A L Sbjct: 2662 VDVDDPGSYATQTDNLPCANTPSDLAYIIYTSGTTGKPKGVMLEHKGVANLQAVFAHHLG 2721 Query: 1488 IQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAIL 1547 + ++R F+SISFD S+ D+ +L G TL + +++++ND F ++ N IT L Sbjct: 2722 VTPQDRAGHFASISFDASVWDMFGPLLSGATLYVLSRDVINDFQRFAEYVRDNAITFLTL 2781 Query: 1548 PPTYLANLNPNNIHTVDKMITIGSAISSGLVNEWKRKCEYINAYGPTETTVYSSVWIANK 1607 PPTY L P + ++ +IT GSA S LV++WK K Y+N YGPTE+TV +++W A K Sbjct: 2782 PPTYAIYLEPEQVPSLRTLITAGSASSVALVDKWKEKVTYVNGYGPTESTVCATLWKA-K 2840 Query: 1608 QGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKII 1667 E + + IGKPI NT++YI+D L+ G GELCI G+ L RGYW RPE+TA+K + Sbjct: 2841 PDEPVETITIGKPIQNTKLYIVDDQLQLKAPGQMGELCISGLSLARGYWNRPELTAEKFV 2900 Query: 1668 TAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKD- 1726 K+YRTGDLARWLPDG +EYLGR+D QVKIRG RVE E+++ LL+ + +K+ Sbjct: 2901 DNPFVPGTKMYRTGDLARWLPDGTIEYLGRIDHQVKIRGHRVELGEVESVLLRYDTVKEA 2960 Query: 1727 VIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGK 1786 +TH ++ Q A +CAYY++ + + +LR + ++LP +M+PA+F+++E PLT N K Sbjct: 2961 AAITHEDDRGQ-AYLCAYYVAEGEATPAQLRAYMENELPNYMVPAFFIQLEKMPLTPNDK 3019 Query: 1787 IDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAM 1846 ID+K LP P R Y P+ E+E +LA +W +VL +++VG +DNFFE+GGDS+KA+ Sbjct: 3020 IDRKALPKPNQEENRTEQYAAPQTELEQLLAGIWADVLGIKQVGTQDNFFELGGDSIKAI 3079 Query: 1847 QVAAILGKHRLHMEIKDLFHRQKIAELS 1874 QV+ L + +K+LF I E + Sbjct: 3080 QVSTRLNASGWTLAMKELFQYPTIEEAA 3107 Score = 1270 bits (3287), Expect = 0.0, Method: Compositional matrix adjust. Identities = 741/2018 (36%), Positives = 1139/2018 (56%), Gaps = 129/2018 (6%) Query: 119 VPIIDTFTTGMTFRESLLQVRETTLGAYDHQDYPFDKI-IEDVQAISDRDFSFVRHVLC- 176 +P G TF E L V + TL Q P++ + + D+Q S + H+L Sbjct: 302 IPFRVQAKAGQTFSELLQAVHKRTL-----QSQPYEHVPLYDIQTQSVLKQELIDHLLVI 356 Query: 177 ----LLTNIHNDAVIPDVGSNI----VFGFTRDDAGI--------SLNLIYNLKYFTRNF 220 L+ + A+ +G I +F T D + + YN F Sbjct: 357 ENYPLVEALQKKALNQQIGFTITAVEMFEPTNYDLTVMVMPKEELAFRFDYNAALFDEQV 416 Query: 221 VMQLAKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQ 280 V +LA QI A N ++L + +T T + T++ELF +Q Sbjct: 417 VQKLAGHLQQIADCVANNSGVELCQIPLLTEAETSQLLAKRTETAADYPAATMHELFSRQ 476 Query: 281 VRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILG 340 +TP+ VAV F +Q +TYR+L+ K+N+LAR LR +G+G +VG L++RS+DM GILG Sbjct: 477 AEKTPEQVAVVFADQHLTYRELDEKSNQLARFLRKKGIGTGSLVGTLLDRSLDMIVGILG 536 Query: 341 ILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLEN 400 +LK+G A++P+D + P ER+ +++ + + + V+ K+ T I ++ V+ E Sbjct: 537 VLKAGGAFVPIDPELPAERIAYMLTHSRVPLVVTQNHLRAKVTTPTET-IDINTAVIGE- 594 Query: 401 ESDLDLILGRALDHPA---YVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRM 457 ES + +L+ P Y+IYTSGTTGQPKGV++EHR+++N + + + + +++ Sbjct: 595 ESRAPI---ESLNQPHDLFYIIYTSGTTGQPKGVMLEHRNMANLMHFTFDQTNIAFHEKV 651 Query: 458 LQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSA 517 LQ + FD F+ ++SG + + R + I +I+ +++P + Sbjct: 652 LQYTTCSFDVCYQEIFSTLLSGGQLYLITNELRRHVEKLFAFIQEKQIS-ILSLPVSFLK 710 Query: 518 LLRNMKPEEAQS----LRIVTLAGEKVTPNLLIASKQLHPGME-----IVNEYGPTESSV 568 + N + + AQS ++ + AGE+ L+ + +L + + N YGP+E+ V Sbjct: 711 FIFNEQ-DYAQSFPRCVKHIITAGEQ-----LVVTHELQKYLRQHRVFLHNHYGPSETHV 764 Query: 569 LATLKRDLKPDDTELT-IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNE 627 + T D EL IGKPI NT +YI+ + L+LK G+VGEL ISGA + RGYLH Sbjct: 765 VTTCTMDPGQAIPELPPIGKPISNTGIYILDEGLQLKPEGIVGELYISGANVGRGYLHQP 824 Query: 628 VLTRDKFVSNPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLL 687 LT +KF+ NP++ ERMYRTGDLA W G++E +GR D QVK+RG+RIELGEIE+RLL Sbjct: 825 ELTAEKFLDNPYQPGERMYRTGDLALWLPDGQLEFLGRIDHQVKIRGHRIELGEIESRLL 884 Query: 688 EYNGITEAVVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQF 747 + I EAVV D+ +CAY+V + LS E+R L+++LPEYM+P+ F LE+ Sbjct: 885 NHPAIKEAVVIDRADETGGKFLCAYVVLQKALSDEEMRAYLAQALPEYMIPSFFVTLERI 944 Query: 748 PMTPTGKMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLG 807 P+TP GK DR AL + + A + PT E+E +LV IW+ +L V + I D+FF LG Sbjct: 945 PVTPNGKTDRRALPKPEGSAKTKADYVAPTTELEQKLVAIWEQILGVSPIGIQDHFFTLG 1004 Query: 808 GHSLKATMLLSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYP 867 GHSLKA L+SR+ KE Q ++ L +FE+ TI LAA ++ Y +I E + YYP Sbjct: 1005 GHSLKAIQLISRIQKECQADVPLRVLFEQPTIQALAAYVEGGEESAYLAIPQAEPQAYYP 1064 Query: 868 MSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIH 927 +SSAQKRM L L+ ST YN+P M++EG LD ++E + +++RHE LRTSFH I+ Sbjct: 1065 VSSAQKRMLILNQLDPHSTVYNLPVAMILEGTLDKARLEHAISNLVARHESLRTSFHTIN 1124 Query: 928 HEPVQVVHDTIDFSIDY---TEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYL 984 EPV +H+ I Y EE+++++ L F+QPFDL T+PL RV ++K+A ++ Sbjct: 1125 GEPVSRIHEQGHLPIVYLETAEEQVNEVIL---GFMQPFDLVTAPLCRVGLVKLAENRHV 1181 Query: 985 FMFDMHHIISDGISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEF 1044 + DMHHIISDG+S L + + + LY N LPE I +KDF+VWEK + D+++QE++ Sbjct: 1182 LIIDMHHIISDGVSSQLILNDFSRLYQNKALPEQRIHYKDFAVWEKAWTQTTDYQKQEKY 1241 Query: 1045 WLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLA 1104 WL F GE+P+L LP+DY RP +S+EG + F +K+ L+++A G TLYM+LLA Sbjct: 1242 WLDRFAGEIPVLNLPMDYPRPAVQSFEGERYLFRTEKQLLESLQDVAQKTGTTLYMVLLA 1301 Query: 1105 LFNIMLSKITNQEDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVK 1164 ++++LSK + Q+D+++G+ R + ES+ GMF NTLAMRN A K F+ FL EVK Sbjct: 1302 AYHVLLSKYSGQDDVMIGTVTAGRVHPDTESMTGMFVNTLAMRNQSAPTKTFRQFLLEVK 1361 Query: 1165 SSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHE 1224 + L+AF++ Y FEE++ KL I R+ RNPLFD + ILQN+ + + + V+ Y E Sbjct: 1362 DNTLAAFEHGQYPFEELVEKLAIQRNRSRNPLFDTLFILQNMDADLIELDGLTVTPYVPE 1421 Query: 1225 HNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISD 1284 +++FD++L E GL C FE+CT+LF RET+E M + I+ V A+ E ++ Sbjct: 1422 GEVAKFDLSLEASENQAGLSFC-FEFCTKLFARETIERMSLHYLQILQAVSANTEQELAQ 1480 Query: 1285 ICMVSENAVQQILA-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNK 1343 I M++ + Q++L FN T+ PA+ T+ LFE+QA++ ++ A+ F D+ ++Y ELN+ Sbjct: 1481 IEMLTAHEKQELLVHFNDTAALYPAESTLSQLFEDQAQKTPEQTAVVFGDKRLTYRELNE 1540 Query: 1344 RANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMI 1403 RANQLA LR KGV A VG+M +RS EM IG + ILK+GGAY+PIDPDYP ERI +M+ Sbjct: 1541 RANQLAHTLRAKGVQAEQSVGIMAQRSLEMAIGIIAILKAGGAYVPIDPDYPNERIAYML 1600 Query: 1404 EDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTG 1463 ED +LVLTQ + + E + L+ G + N+ I+ ++DLAY+IYTSGTTG Sbjct: 1601 EDCR-RLVLTQQQLAEKMTANVECLYLDEEGSYSPQTENIEPIHTAADLAYIIYTSGTTG 1659 Query: 1464 KPKGTLLEHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTT 1523 +PKG ++EH+GIVN N+++ + R+ S +FD + I+ G T+ L Sbjct: 1660 RPKGVMVEHRGIVNSVTWNRDEFALSVRDSGTLSLSFAFDAFALTFFTLIVSGSTVVLMP 1719 Query: 1524 KEILNDNSCFEAFLNSNRITAAILPPTYLANL----NPNNIHTVDKMITIGSAISSGLVN 1579 D + + + + P+ + P +I ++ ++ G +S LV Sbjct: 1720 DHEAKDPIALRNLIAAWECSYVVFVPSMFQAILECSTPADIRSIQAVMLGGEKLSPKLVQ 1779 Query: 1580 EWKR---KCEYINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQ 1636 K + +NAYGPTE++V ++ + + D P+ IG+PI NT +YI+D++ L Sbjct: 1780 LCKAMHPQMSVMNAYGPTESSVMATYL---RDTQPDQPITIGRPIANTAIYIVDQHHQLL 1836 Query: 1637 PVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLG 1696 PVG+ GE+CIGG GL RGYWK+PE+TA+K + ++Y+TGDL RWL DG ++++G Sbjct: 1837 PVGVVGEICIGGHGLARGYWKKPELTAEKFVANPAVPGERMYKTGDLGRWLHDGTIDFIG 1896 Query: 1697 RMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTEL 1756 R+D+Q+K+RG+R+E EI+A LL + + IV ++ + + AY +EL Sbjct: 1897 RVDDQIKVRGYRIEVGEIEAVLLAYDQTNEAIVVAYQDDRGDSYLAAYVTGKTAIEESEL 1956 Query: 1757 RKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELML 1816 R LL +LP +M+P Y ++++AFPLT NGK+D+K LP PE + Y+ P E+E L Sbjct: 1957 RAHLLRELPAYMVPTYLIQLDAFPLTPNGKVDRKALPKPEGKPATGAAYVAPATEVEAKL 2016 Query: 1817 AEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGKHRLHMEIK-DLFHRQKIAELSE 1875 +WE L + VG+ D+FFE+GG SLKAM V A ++H E + DL +Q A + Sbjct: 2017 VAIWENALGISGVGVLDHFFELGGHSLKAMTVVA-----QVHREFQIDLLLKQFFA--AP 2069 Query: 1876 CVRDLRNNPIVENPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKH 1935 +RDL I+ S A+I+ P Sbjct: 2070 TIRDLAR---------LIEHSEQAAGAAIQ---------------------PAEPQAYYP 2099 Query: 1936 LPAAVQKYHLMNAEKVHTSIPFRSCGDI---GKIQK-----AILRLVNEQVLLRSVIVND 1987 + +A Q+ +L++ + I + + G I GK+ + A+ LV+ +LR+ Sbjct: 2100 VSSAQQRMYLLH-QLEGAGISYNTPGIIMLEGKLDREQLANALQALVDRHDILRTSFEMV 2158 Query: 1988 GENTYFYEHGSV-YNLPFILIDLSGFDAARRSECLAYLQDHFNKL--PFERDNGLLYRLV 2044 G+ H V N+ ++ + D D F+ PF+ L R+ Sbjct: 2159 GDELVQKIHDRVAVNMEYVTAEEQQID------------DLFHAFVRPFDLSVPPLLRMS 2206 Query: 2045 LVQTAPEDYMLLYSADHAVSDGLSLGIITDQLAAYFAG 2082 LV+ A E ++LLY H +D S+ I+ D+LA + G Sbjct: 2207 LVKLADERHLLLYDMHHIAADAASITILFDELAELYQG 2244 Score = 543 bits (1400), Expect = e-152, Method: Compositional matrix adjust. Identities = 383/1282 (29%), Positives = 649/1282 (50%), Gaps = 106/1282 (8%) Query: 863 RDYYPMSSAQKRMYALYH--LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILR 920 +D Y ++ Q+ M L+H L+ E S+ + + ++G+LDVG L ++ R+++ R Sbjct: 10 QDMYALTPMQEGM--LFHALLDQEHNSHLVQMSISLQGDLDVGLFTDSLHVLVERYDVFR 67 Query: 921 TSF-HMIHHEPVQVVHDTIDFSIDYTEEKIDDIRLEADRFIQ--------PFDLDTSPLF 971 T F + +P+QVV I++ + D + R+ Q F L PL Sbjct: 68 TLFLYEKLKQPLQVVLKQRPIPIEFYDLSACDESEKQLRYTQYKRADQERTFHLAKDPLM 127 Query: 972 RVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLY-----GNAVLPEPEIQFKDFS 1026 RV + +++ Y ++ HHI+ DG + +L +Y A+ EP + F Sbjct: 128 RVALFQMSQHDYQVIWSFHHILMDGWCFSIIFDDLLAIYLSLQNKTALSLEPVQPYSRFI 187 Query: 1027 VWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRK 1086 W ++ + +W + LP + K+++ ++ F+L++ T++ Sbjct: 188 NWLEKQNKQAALN----YWSDYLEAYEQKTTLP-KKEAAFAKAFQPTQYRFSLNRTLTKQ 242 Query: 1087 LKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQ--VELESVMGMFSNTL 1144 L +A N TL ++ ++ ++L K D++ GS V+ R V ++ ++G+F NT+ Sbjct: 243 LGTIASQNQVTLSTVIQTIWGVLLQKYNAAHDVLFGSVVSGRPTDIVGIDKMVGLFINTI 302 Query: 1145 AMRNFPAGNKRFKDFLNEVKSSALSA----------FDNQDYQFEEMISKLDIVRDTGRN 1194 R + F + L V L + Q +E+I L ++ + Sbjct: 303 PFRVQAKAGQTFSELLQAVHKRTLQSQPYEHVPLYDIQTQSVLKQELIDHLLVIENY--- 359 Query: 1195 PLFDAMLILQNIAVN-QFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYCTR 1253 PL +A LQ A+N Q F V +E + +D+T+ + + L F+Y Sbjct: 360 PLVEA---LQKKALNQQIGFTITAVEMFEP----TNYDLTVMVMPKEE--LAFRFDYNAA 410 Query: 1254 LFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILA-FNQTSFDLPADQTI 1312 LF + V+ + +L+ I + V + + + I +++E Q+LA +T+ D PA T+ Sbjct: 411 LFDEQVVQKLAGHLQQIADCVANNSGVELCQIPLLTEAETSQLLAKRTETAADYPA-ATM 469 Query: 1313 HGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFE 1372 H LF QA++ ++ A+ F DQ ++Y EL++++NQLAR LR+KG+ GS+VG + +RS + Sbjct: 470 HELFSRQAEKTPEQVAVVFADQHLTYRELDEKSNQLARFLRKKGIGTGSLVGTLLDRSLD 529 Query: 1373 MMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNC 1432 M++G LG+LK+GGA++PIDP+ P ERI +M+ S + LV+TQN + E ID+N Sbjct: 530 MIVGILGVLKAGGAFVPIDPELPAERIAYMLTHSRVPLVVTQNHLRAKVTTPTETIDINT 589 Query: 1433 AGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRE 1492 A + + + +N+ DL Y+IYTSGTTG+PKG +LEH+ + NL +Q I E Sbjct: 590 AVIGEESRAPIESLNQPHDLFYIIYTSGTTGQPKGVMLEHRNMANLMHFTFDQTNIAFHE 649 Query: 1493 RVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYL 1552 +V+Q+++ SFDV +I ++L GG L L T E+ AF+ +I+ LP ++L Sbjct: 650 KVLQYTTCSFDVCYQEIFSTLLSGGQLYLITNELRRHVEKLFAFIQEKQISILSLPVSFL 709 Query: 1553 A------NLNPNNIHTVDKMITIGSA-ISSGLVNEWKRKCEYI--NAYGPTETTVYSSVW 1603 + + V +IT G + + + ++ R+ N YGP+ET V ++ Sbjct: 710 KFIFNEQDYAQSFPRCVKHIITAGEQLVVTHELQKYLRQHRVFLHNHYGPSETHVVTTCT 769 Query: 1604 IANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTA 1663 + Q + P PIGKPI NT +YILD+ L+P GI GEL I G + RGY +PE+TA Sbjct: 770 MDPGQAIPELP-PIGKPISNTGIYILDEGLQLKPEGIVGELYISGANVGRGYLHQPELTA 828 Query: 1664 DKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEG 1723 +K + ++YRTGDLA WLPDG LE+LGR+D QVKIRG R+E EI++ LL Sbjct: 829 EKFLDNPYQPGERMYRTGDLALWLPDGQLEFLGRIDHQVKIRGHRIELGEIESRLLNHPA 888 Query: 1724 IKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTS 1783 IK+ +V R ++ +CAY + S E+R L LPE+MIP++FV +E P+T Sbjct: 889 IKEAVVIDRADETGGKFLCAYVVLQKALSDEEMRAYLAQALPEYMIPSFFVTLERIPVTP 948 Query: 1784 NGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSL 1843 NGK D++ LP PE S + + Y+ P E+E L +WE++L + +GI+D+FF +GG SL Sbjct: 949 NGKTDRRALPKPEGSAKTKADYVAPTTELEQKLVAIWEQILGVSPIGIQDHFFTLGGHSL 1008 Query: 1844 KAMQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSSGTEGDAS 1903 KA+Q+ + + K EC D+ + E P + ++ EG Sbjct: 1009 KAIQLISRIQK--------------------ECQADVPLRVLFEQPTIQALAAYVEGGEE 1048 Query: 1904 IEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHTSIPFRSCGDI 1963 L + + + Q S + L+ L Y+L A + ++ D Sbjct: 1049 SAYLA---IPQAEPQAYYPVSSAQKRMLILNQLDPHSTVYNLPVAMILEGTL------DK 1099 Query: 1964 GKIQKAILRLVNEQVLLRSVI--VNDGENTYFYEHGSVYNLPFILIDLSGFDAARRSECL 2021 +++ AI LV LR+ +N + +E G +LP + ++ + + L Sbjct: 1100 ARLEHAISNLVARHESLRTSFHTINGEPVSRIHEQG---HLPIVYLETA--EEQVNEVIL 1154 Query: 2022 AYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQLAAYFA 2081 ++Q PF+ L R+ LV+ A ++L+ H +SDG+S +I + + + Sbjct: 1155 GFMQ------PFDLVTAPLCRVGLVKLAENRHVLIIDMHHIISDGVSSQLILNDFSRLYQ 1208 Query: 2082 GDSSLPVHSLKHHQNY--WDYA 2101 + +LP + H++++ W+ A Sbjct: 1209 -NKALPEQRI-HYKDFAVWEKA 1228 Score = 510 bits (1314), Expect = e-142, Method: Compositional matrix adjust. Identities = 347/1128 (30%), Positives = 556/1128 (49%), Gaps = 62/1128 (5%) Query: 1 MSIQNANINV----LLSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRL 56 M IQ + V L + K+++ YWL+ G+ T + TD + A+ + L Sbjct: 2250 MRIQYKDFAVWQKALHESDAFKQQEAYWLSTFAGNITAVDVPTDFPRPAVKSFAGGQVTL 2309 Query: 57 DIPDGLFQQLQHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSE--- 113 + L L L+ ++ +L+ +LL A L+ K+ I V +P+ S +E Sbjct: 2310 SMDQELLSALHELAAHTNTTLFMVLLAAYNVLLAKYAGQDDIIVGTPI--SGRSRAELAP 2367 Query: 114 ---AYNHYVPIIDTFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSF 170 + H + I + T TF++ L +V++ L A+DHQDYPF+ ++E + D + Sbjct: 2368 VVGMFVHTLAIRNKPTAEKTFKQFLQEVKQNALDAFDHQDYPFESLVEKLGIPRDPGRNP 2427 Query: 171 VRHVLCLLTN--IH-------------NDAVIPDVGSNIVFGFTRDDAGISLNLIYNLKY 215 + + +L N +H +D+ + ++ F T + + L L Y K Sbjct: 2428 LFDTMFILQNDELHAKTLDQLVYRPYESDSALDVAKFDLSFHLTERETDLFLRLEYCTKL 2487 Query: 216 FTRNFVMQLAKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNME-DMTLY 274 F + V ++A + QIL+ N +L + T++ D T+ Sbjct: 2488 FKQQTVERMAHHFLQILRAVTANPENELQEIEMLTAAEKQMLLVAFNDTHREYRADQTIQ 2547 Query: 275 ELFEKQVRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDM 334 +LFE+ + P+H A+ F + +++R+LN +AN+LA VLR +GVG QIV LLVERS +M Sbjct: 2548 QLFEELAEKMPEHTALVFEEKRMSFRELNERANQLAAVLREKGVGPAQIVALLVERSAEM 2607 Query: 335 AGGILGILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDD 394 L LK+G A+LP+D PEER+++++ED+ ++ V++ K+ V+ +DD Sbjct: 2608 VIATLATLKAGGAFLPVDPDYPEERIRYMLEDSQAKLVVTHAHLLHKVSSQS-EVVDVDD 2666 Query: 395 DVLLENESDLDLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDAS 454 ++D +L AY+IYTSGTTG+PKGV++EH+ ++N Sbjct: 2667 PGSYATQTD-NLPCANTPSDLAYIIYTSGTTGKPKGVMLEHKGVANLQAVFAHHLGVTPQ 2725 Query: 455 DRMLQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTL 514 DR S FD + F P++SGAT+ L D + + + IT F+ +P Sbjct: 2726 DRAGHFASISFDASVWDMFGPLLSGATLYVLSRDVINDFQRFAEYVRDNAIT-FLTLPPT 2784 Query: 515 YSALLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKR 574 Y+ L +PE+ SLR + AG + L+ K+ + VN YGPTES+V ATL + Sbjct: 2785 YAIYL---EPEQVPSLRTLITAGSASSVALVDKWKE---KVTYVNGYGPTESTVCATLWK 2838 Query: 575 DLKPDDT--ELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRD 632 KPD+ +TIGKPI NT++YIV D L+LKA G +GELCISG LARGY + LT + Sbjct: 2839 -AKPDEPVETITIGKPIQNTKLYIVDDQLQLKAPGQMGELCISGLSLARGYWNRPELTAE 2897 Query: 633 KFVSNPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGI 692 KFV NPF +MYRTGDLARW G IE +GR D QVK+RG+R+ELGE+E+ LL Y+ + Sbjct: 2898 KFVDNPFVPGTKMYRTGDLARWLPDGTIEYLGRIDHQVKIRGHRVELGEVESVLLRYDTV 2957 Query: 693 TEAVVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPT 752 EA ED + +CAY V + + +LR + LP YM+P F QLE+ P+TP Sbjct: 2958 KEAAAITHEDDRGQAYLCAYYVAEGEATPAQLRAYMENELPNYMVPAFFIQLEKMPLTPN 3017 Query: 753 GKMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLK 812 K+DR AL + ++ P E+E L IW +VL + +V DNFF LGG S+K Sbjct: 3018 DKIDRKALPKPNQEENRTEQYAAPQTELEQLLAGIWADVLGIKQVGTQDNFFELGGDSIK 3077 Query: 813 ATMLLSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQ 872 A + +RL+ + + E+F+ TI A + + ++ E ++ Q Sbjct: 3078 AIQVSTRLNASGWT-LAMKELFQYPTIEEAALRVIPNSRESEQGVVEGE----IALTPIQ 3132 Query: 873 KRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQ 932 K +A + + +N ++ E D G V +Q++ H+ LR + Q Sbjct: 3133 KWFFA--NNFTDRHHWNQAVMLFREDGFDEGLVRQAFQQIVEHHDALRMVYKQEDGAIKQ 3190 Query: 933 VVHDTID-----FSIDYTEEKIDDIRL--EADRFIQPFDLDTSPLFRVKIIKIASRHYLF 985 + D +S D + R+ +D+ DL+ PL V + +L Sbjct: 3191 INRGLTDERFRFYSYDLKNHANSEARILELSDQIQSSIDLEHGPLVHVALFATKDGDHL- 3249 Query: 986 MFDMHHIISDGISIGLFIKELALLYGNA------VLPEPEIQFKDFSVWEKESAENGDFK 1039 + +HH++ DG+S + ++ + Y A VLP+ FKD++ ++ A++ + Sbjct: 3250 LVAIHHLVVDGVSWRILFEDFSSAYSQALHQQEIVLPKKTDSFKDWAAQLQKYADSDELL 3309 Query: 1040 QQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKL 1087 ++ +W + + LP D+ K + F L T L Sbjct: 3310 REVAYWHNL-ETTTTTAALPTDFVTADRKQKHTRTLSFALTVPQTENL 3356 >C0ZDA6.1 C0ZDA6_BREBN Tyrocidine synthetase II EC=5.1.1.11 Length = 3589 Score = 1476 bits (3820), Expect = 0.0, Method: Compositional matrix adjust. Identities = 827/2123 (38%), Positives = 1237/2123 (58%), Gaps = 77/2123 (3%) Query: 11 LLSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRLDIPDGLFQQLQHLS 70 L T E +K++ YW R + D + ++ E L LQ ++ Sbjct: 1229 LAQTDEYRKQEAYWTQRFADEIPVLNLPLDYSRPSVQSSEGERYLFRSEKQLSDGLQRVA 1288 Query: 71 NRSDDSLYYILLTALKWLIVKHTESSIITV----ASPVYMDENSTSEAYNHYVPIIDTFT 126 + +LY +L+ A L+ K++ + V A + D S + + + + + + Sbjct: 1289 AETGTTLYMVLMAAYHVLLAKYSGQEDMVVGTVTAGRTHPDTESITGMFVNTLAMRNQPV 1348 Query: 127 TGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHND-- 184 +F++ L +V++ TL A++H +YPF++++E + +R + + L +L N+ D Sbjct: 1349 ATKSFKQFLQEVKDNTLAAFEHGEYPFEELVEKLAVNRNRSRNPLFDTLFILQNMDADPI 1408 Query: 185 -----AVIPDVGSNIVFGF------TRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQILK 233 V P V + F T++ AG+ + K F + + ++++ Y QIL+ Sbjct: 1409 NIEGMTVTPYVPEGKMAKFDLSLEATQNHAGLLFCFEFCTKLFKQETIERMSRHYIQILQ 1468 Query: 234 GAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNME-DMTLYELFEKQVRQTPDHVAVKF 292 +N ++ L + T + ++ + TL +LFE+QV +TPD +A+ Sbjct: 1469 EITQNTNLALYEIEMLTEQEKQELLVHFNDTSKPVQLESTLTQLFEEQVGKTPDQIALVC 1528 Query: 293 NNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLPLD 352 ++ +TY++LN KAN+LAR LR +GV A+Q VG++ RS++M GIL ILKSG AY+P+D Sbjct: 1529 GDKKLTYQELNKKANQLARTLRKKGVKADQRVGIMANRSLEMVIGILAILKSGGAYVPID 1588 Query: 353 IKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLEN-ESDLDLILGRA 411 + P +R+ +++ED + ++ + K+ G+ + L+D ++LD I Sbjct: 1589 PEYPNDRIAYMLEDCEARLVLTQEHLGAKVAA-GVECLYLEDKSNYSRITTNLDPI--HT 1645 Query: 412 LDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDGFLTS 471 H AY+IYTSGTTG+PKGV+ EHR I N++ W K E + DR L S+ FD F + Sbjct: 1646 ATHLAYIIYTSGTTGKPKGVMGEHRGIVNSVTWNKQELALSVHDRGLLPLSFAFDAFALT 1705 Query: 472 FFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEAQSLR 531 FF I+SG+TVV + EA+DP+A+ LI+ ++ + VP+++ A+L EE L+ Sbjct: 1706 FFALIISGSTVVLTKDEEAKDPIALKNLISSWSCSYTVCVPSMFQAILECSTTEEISPLK 1765 Query: 532 IVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELTIGKPIGN 591 +V L GEK++P L+ K+++P M VN YGPTESSV+AT D PD +TIG+PI N Sbjct: 1766 MVMLGGEKLSPKLVEMCKEMNPQMITVNAYGPTESSVIATYLCDALPD-APITIGRPIAN 1824 Query: 592 TRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERMYRTGDL 651 T +YIV + +L G+VGE+CI G GLARGY + LT +KFVSNPF ERMY+TGDL Sbjct: 1825 TSIYIVDHSHQLLPIGVVGEICIGGLGLARGYWNKPELTEEKFVSNPFVPGERMYKTGDL 1884 Query: 652 ARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNSRICA 711 RW G IE GR D QVK+RGYRIE+GEIE+ L Y EA+V ++D + ++ + A Sbjct: 1885 GRWLPDGTIEFAGRLDEQVKVRGYRIEIGEIESVLFSYEMTNEAIVVAYQDGSGDAYLAA 1944 Query: 712 YIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLKELGA 771 Y +S + LR LS+ LP YM+PT+ QL+ FP+TP GK+DR AL + G Sbjct: 1945 YFTGKENISEVALRTHLSQELPAYMVPTYLVQLDTFPLTPNGKIDRKALPKPEGKPTTGV 2004 Query: 772 RFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVEIELD 831 + P NE+E+ L +IW+NVL + + + DNFF LGGHSLKA +++ +H+EFQ+++ L Sbjct: 2005 EYAAPANEVEATLAKIWENVLGISGIGVMDNFFELGGHSLKAMTVVAHVHREFQIDLTLK 2064 Query: 832 EIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGESTSYNMP 891 FE+ T+ L+ LI + + + I P E+++YYP+SSAQ+RMY L+ LEG SYN P Sbjct: 2065 HFFEQPTVRALSRLIANSENTSDALIQPAERQEYYPVSSAQQRMYVLHQLEGAGISYNTP 2124 Query: 892 EVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDY---TEEK 948 ++++EG+LD Q+ L+ ++ RHEI RTSF M+ + VQ +HD ++ + Y E + Sbjct: 2125 GMIMLEGQLDRDQMVHALQALVDRHEIWRTSFEMLGDQLVQKIHDRVEVEMAYRSAEEHQ 2184 Query: 949 IDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELAL 1008 ID+I F+ PFDL PL R+ +++I+ ++ ++DMHHI SD S+ L ELA Sbjct: 2185 IDEI---FQAFVHPFDLAVPPLLRMGLVQISDERHVLLYDMHHIASDASSVPLIFNELAE 2241 Query: 1009 LYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHK 1068 LY LPE IQ+KDFSVW+K E+ DFK+QEE+W F+G +LE+P D+ RP K Sbjct: 2242 LYQGRQLPELRIQYKDFSVWQKRFTESDDFKKQEEYWRHAFEGHNSVLEIPTDFPRPPVK 2301 Query: 1069 SYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRR 1128 S+EG +I D+ L LA + TL+M+LLA +N++LSK T Q+DI+VG+P++ + Sbjct: 2302 SFEGDQIVLATDRPLLEALHALAAETKTTLFMVLLAAYNVLLSKYTGQDDIVVGTPISGK 2361 Query: 1129 RQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIV 1188 + ELE ++GMF NTLA+RN P K FK+FL EVK +AL A+D+QDY E ++ KL I Sbjct: 2362 TRAELEPIVGMFVNTLAIRNKPTAEKTFKEFLMEVKQNALDAYDHQDYPLESLVEKLGIQ 2421 Query: 1189 RDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEH--NISRFDITLHCLEGLDGLLHC 1246 RD GRNPLFD M ILQ + Q G++ YE IS+FD++ H E LL Sbjct: 2422 RDPGRNPLFDTMFILQTDELYQKTLGQLTYHPYEPTSALAISKFDLSFHLTERETDLL-L 2480 Query: 1247 SFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILA-FNQTSFD 1305 EY T+LF+R+TV+ M + I+ V A+ + ++ I M++ Q +L FN T + Sbjct: 2481 RLEYSTKLFRRDTVDRMSRHFMQILRNVAAEPDRQLQAIEMLTAEEKQLLLVEFNHTDRE 2540 Query: 1306 LPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGL 1365 DQTI LFEE D+ A+ F ++ M+Y ELN+RANQLA +LREKG+ +V + Sbjct: 2541 YTEDQTIQQLFEELVANTPDQTAIVFEEKQMTYEELNERANQLATVLREKGLGPSQIVVM 2600 Query: 1366 MFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDG 1425 M ERS EM+I L ILK+GGA+LP+DPDYP ERI++MIEDS +LVLT + + + Sbjct: 2601 MVERSLEMVIATLAILKAGGAFLPVDPDYPEERIRYMIEDSQAKLVLTHSHLIHKVSSQA 2660 Query: 1426 EVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQ 1485 E+IDL A + NL IN+ SDLAY+IYTSGTTG PKG +LEHKG NL A K Sbjct: 2661 EIIDLGDAESYSAQTDNLLCINKPSDLAYIIYTSGTTGNPKGVMLEHKGAANLQAMFKNH 2720 Query: 1486 LKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAA 1545 + ++R F+SISFD S+ D+ M++L G TL + +++ +ND FE +++ N IT Sbjct: 2721 FGVTPQDRPGHFASISFDASVWDMFMALLTGATLYIISRDTINDFRKFEEYVHKNGITIL 2780 Query: 1546 ILPPTYLANLNPNNIHTVDKMITIGSAISSGLVNEWKRKCEYINAYGPTETTVYSSVWIA 1605 LPPTY L P+ + ++ +IT GSA S+ LV +WK K YINAYGPTE+T+ ++ W A Sbjct: 2781 TLPPTYAIYLEPDRMPSLRILITAGSAASTALVEQWKEKVTYINAYGPTESTICATTWKA 2840 Query: 1606 NKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADK 1665 V + IGKPI NT+++I+D+ L+ VG GELCI G+ L RGYW RPE+TA+K Sbjct: 2841 LPHEPVGQTITIGKPIQNTKLFIVDEQMQLKTVGQIGELCISGVALARGYWNRPELTAEK 2900 Query: 1666 IITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIK 1725 + K+YRTGDLA+WLPDGN+EYLGR+D QVK+RG RVE E+++ LL+ E I Sbjct: 2901 FVDNPFVPGEKMYRTGDLAKWLPDGNIEYLGRIDHQVKVRGHRVELGEVESVLLRYETIV 2960 Query: 1726 DVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNG 1785 + + + L +CAYY++ S +LR+ + +LP +M+P++FV+M+ PLT N Sbjct: 2961 EAVAITHLDDLGQPYLCAYYVADGAASPAQLREFMGKELPNYMVPSFFVQMDKMPLTPND 3020 Query: 1786 KIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKA 1845 KID+K LP P + + Y P+NE+E +LA W EVL + +VG++DNFFE+GGDS+KA Sbjct: 3021 KIDRKALPKPSHEEKPGREYEAPQNELEHLLATTWAEVLGIGQVGMKDNFFELGGDSIKA 3080 Query: 1846 MQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSSGTEGDASIE 1905 +QV+ L + +K+LF I +++ V + NN D EG+ + Sbjct: 3081 IQVSTRLHAAGWTLAMKELFQYPTIEQVAAHV--IPNN-------RESDQGVVEGEIDLT 3131 Query: 1906 VLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHTSIPFRSCG-DIG 1964 + W E RN ++H A + FR G D G Sbjct: 3132 PIQK-WFFE------------RN----------FTDRHHWNQAVML-----FREDGFDPG 3163 Query: 1965 KIQKAILRLVNEQVLLRSVIVNDGEN-TYFYEHGSVYNLPFILIDLSGFDAARRSECLAY 2023 +Q+A ++V LR + + E T + F DL D A + + Sbjct: 3164 LVQQAFYKIVEHHDALRMIYKQENETITQINRALTGERFRFHSYDLK--DHANSAAHIWE 3221 Query: 2024 LQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQL-AAYFAG 2082 L +H + + G L L L T D++L+ + H V DG+S I+ + +AY Sbjct: 3222 LSNHIQS-SIDLEQGPLVHLALFSTTEGDHLLI-AIHHLVVDGVSWRILFEDFSSAYSQA 3279 Query: 2083 DSSLPVHSLKHHQNYWDYADQMQ 2105 + + K ++ D++ Q+Q Sbjct: 3280 LHNQEIVLPKKTDSFKDWSAQLQ 3302 Score = 1269 bits (3284), Expect = 0.0, Method: Compositional matrix adjust. Identities = 685/1698 (40%), Positives = 1031/1698 (60%), Gaps = 32/1698 (1%) Query: 205 ISLNLIYNLKYFTRNFVMQLAKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRT 264 I++ YN F F+ ++A QI A N + L + T Sbjct: 401 IAMRFDYNAAVFDDAFIQKMAGHLKQIATWVANNPRVNLQQVTLLTETEKQQLMARNLDT 460 Query: 265 YQNMEDMTLYELFEKQVRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIV 324 T++ELF +QV +TPDHVAV F Q +TYR+L+ K+N+LAR LR +G+ A+ +V Sbjct: 461 SAAYPTKTMHELFMEQVERTPDHVAVVFGEQHLTYRELDEKSNQLARFLRGKGIAADSLV 520 Query: 325 GLLVERSIDMAGGILGILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKR 384 G +++RSI+M GILG+LK+G A++P+D + PEER+ +++E +GI+ V+ + EKL Sbjct: 521 GTMMDRSIEMIVGILGVLKAGGAFVPIDPELPEERIAYMLEHSGIQWVVTQQHLLEKLSA 580 Query: 385 DGLTVIRLDDDVLLENESDLDLILGRALDHPA---YVIYTSGTTGQPKGVIIEHRSISNT 441 T+ + E+ + +++I + P Y+IYTSGTTG+PKGV++EH++++N Sbjct: 581 STETIDISAPAIWEESSASVEMI-----NQPEDLFYIIYTSGTTGKPKGVMLEHQNMANL 635 Query: 442 IQWRKSEYSFDASDRMLQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLIT 501 + + ++ + D +++LQ + FD F+ ++SG + + R+ + I Sbjct: 636 MHFTFAKTNIDFHEKVLQYTTCSFDVCYQEIFSTLLSGGQLYLITNEMRRNVEKLFAFIQ 695 Query: 502 LHKITHFIAVPTLYSALLRNMKPEEAQS----LRIVTLAGEK--VTPNLLIASKQLHPGM 555 ++I+ +++P + + N K + AQS ++ + AGE+ VT L + H + Sbjct: 696 ENQIS-ILSLPVSFLKFIFNEK-DYAQSFPRCVKHIITAGEQLVVTHELQKYLRNHHVFL 753 Query: 556 EIVNEYGPTESSVLATLKRDLKPDDTELT-IGKPIGNTRVYIVGDNLELKAAGMVGELCI 614 N YGP+E+ V+ T D D EL IGKPI NT +YI+ + L+LK G+VGEL I Sbjct: 754 H--NHYGPSETHVVTTYTMDPSMDIPELPPIGKPISNTGIYILDEKLQLKPEGIVGELYI 811 Query: 615 SGAGLARGYLHNEVLTRDKFVSNPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRG 674 SGA + RGYLHN LT +KF+ NP+++ ERMYRTGDLARW G IE +GR D QVK+RG Sbjct: 812 SGANVGRGYLHNPELTAEKFLENPYQSGERMYRTGDLARWMPDGNIEFLGRIDHQVKIRG 871 Query: 675 YRIELGEIENRLLEYNGITEAVVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPE 734 +RIELGEIE+ LL + I EAVV D+ +CAY+V +S ELR LS++LPE Sbjct: 872 HRIELGEIESHLLNHALIKEAVVIDRTDETGGKYLCAYVVLAEEVSNEELRAYLSRTLPE 931 Query: 735 YMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEV 794 YM+P+ F +LE+ P+TP GK DR AL + GA + PT E+E ++ IW++VL V Sbjct: 932 YMIPSFFMKLERIPVTPNGKTDRRALPIPEGNAFTGADYLAPTTELEQKMAAIWESVLGV 991 Query: 795 DKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTY 854 + I DNFF LGGHSLKA L+SR+ K+ Q ++ L +F++ TI +A ++ + GTY Sbjct: 992 SPIGIQDNFFTLGGHSLKAIHLISRMQKDCQTDVPLRVLFDRPTIQEIAKYVEGEEAGTY 1051 Query: 855 SSILPTEKRDYYPMSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMIS 914 +I +++YP+SSAQKRM L L+ ST YN+P V V++GEL+V Q+E+ + ++S Sbjct: 1052 LAIPQVTMQEHYPVSSAQKRMLILNQLDPASTVYNLPVVTVLDGELNVPQMENAISGLVS 1111 Query: 915 RHEILRTSFHMIHHEPVQVVHDTIDFSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVK 974 RHE LRTSFH I+ E VQ +H I Y E + + F++PFDL+ +PL RV Sbjct: 1112 RHESLRTSFHTINGELVQRIHPECKLPIAYMEATENRLNQVITDFMRPFDLEKAPLSRVG 1171 Query: 975 IIKIASRHYLFMFDMHHIISDGISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAE 1034 ++K+ R ++ + DMHHIISDG+S + + +LA LY + LPE IQ+KDF+VWEK A+ Sbjct: 1172 LVKLGERRHVMIIDMHHIISDGVSSQIILNDLAQLYQDKSLPEQRIQYKDFAVWEKGLAQ 1231 Query: 1035 NGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDN 1094 ++++QE +W + F E+P+L LP+DY RP +S EG + F +K+ + L+ +A + Sbjct: 1232 TDEYRKQEAYWTQRFADEIPVLNLPLDYSRPSVQSSEGERYLFRSEKQLSDGLQRVAAET 1291 Query: 1095 GATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNK 1154 G TLYM+L+A ++++L+K + QED++VG+ R + ES+ GMF NTLAMRN P K Sbjct: 1292 GTTLYMVLMAAYHVLLAKYSGQEDMVVGTVTAGRTHPDTESITGMFVNTLAMRNQPVATK 1351 Query: 1155 RFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFG 1214 FK FL EVK + L+AF++ +Y FEE++ KL + R+ RNPLFD + ILQN+ + Sbjct: 1352 SFKQFLQEVKDNTLAAFEHGEYPFEELVEKLAVNRNRSRNPLFDTLFILQNMDADPINIE 1411 Query: 1215 EMKVSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQV 1274 M V+ Y E +++FD++L + GLL C FE+CT+LFK+ET+E M + I+ ++ Sbjct: 1412 GMTVTPYVPEGKMAKFDLSLEATQNHAGLLFC-FEFCTKLFKQETIERMSRHYIQILQEI 1470 Query: 1275 IADREIRISDICMVSENAVQQILA-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLD 1333 + + + +I M++E Q++L FN TS + + T+ LFEEQ + D+ AL D Sbjct: 1471 TQNTNLALYEIEMLTEQEKQELLVHFNDTSKPVQLESTLTQLFEEQVGKTPDQIALVCGD 1530 Query: 1334 QTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPD 1393 + ++Y ELNK+ANQLAR LR+KGV A VG+M RS EM+IG L ILKSGGAY+PIDP+ Sbjct: 1531 KKLTYQELNKKANQLARTLRKKGVKADQRVGIMANRSLEMVIGILAILKSGGAYVPIDPE 1590 Query: 1394 YPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLA 1453 YP +RI +M+ED +LVLTQ + E + L + +NL I+ ++ LA Sbjct: 1591 YPNDRIAYMLEDCEARLVLTQEHLGAKVAAGVECLYLEDKSNYSRITTNLDPIHTATHLA 1650 Query: 1454 YMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSI 1513 Y+IYTSGTTGKPKG + EH+GIVN NK++L + +R + S +FD + I Sbjct: 1651 YIIYTSGTTGKPKGVMGEHRGIVNSVTWNKQELALSVHDRGLLPLSFAFDAFALTFFALI 1710 Query: 1514 LLGGTLCLTTKEILNDNSCFEAFLNSNRITAAI-LPPTYLANLNPNNIHTVD--KMITIG 1570 + G T+ LT E D + ++S + + +P + A L + + KM+ +G Sbjct: 1711 ISGSTVVLTKDEEAKDPIALKNLISSWSCSYTVCVPSMFQAILECSTTEEISPLKMVMLG 1770 Query: 1571 S-AISSGLV---NEWKRKCEYINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQM 1626 +S LV E + +NAYGPTE++V ++ D P+ IG+PI NT + Sbjct: 1771 GEKLSPKLVEMCKEMNPQMITVNAYGPTESSVIATYLC---DALPDAPITIGRPIANTSI 1827 Query: 1627 YILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARW 1686 YI+D L P+G+ GE+CIGG+GL RGYW +PE+T +K ++ ++Y+TGDL RW Sbjct: 1828 YIVDHSHQLLPIGVVGEICIGGLGLARGYWNKPELTEEKFVSNPFVPGERMYKTGDLGRW 1887 Query: 1687 LPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYI 1746 LPDG +E+ GR+DEQVK+RG+R+E EI++ L E + IV ++ A + AY+ Sbjct: 1888 LPDGTIEFAGRLDEQVKVRGYRIEIGEIESVLFSYEMTNEAIVVAYQDGSGDAYLAAYFT 1947 Query: 1747 SAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYI 1806 + S LR L +LP +M+P Y V+++ FPLT NGKID+K LP PE Y Sbjct: 1948 GKENISEVALRTHLSQELPAYMVPTYLVQLDTFPLTPNGKIDRKALPKPEGKPTTGVEYA 2007 Query: 1807 PPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGKH-RLHMEIKDLF 1865 P NE+E LA++WE VL + +G+ DNFFE+GG SLKAM V A + + ++ + +K F Sbjct: 2008 APANEVEATLAKIWENVLGISGIGVMDNFFELGGHSLKAMTVVAHVHREFQIDLTLKHFF 2067 Query: 1866 HRQKIAELSECVRDLRNN 1883 + + LS + + N Sbjct: 2068 EQPTVRALSRLIANSENT 2085 Score = 541 bits (1394), Expect = e-151, Method: Compositional matrix adjust. Identities = 391/1292 (30%), Positives = 652/1292 (50%), Gaps = 131/1292 (10%) Query: 863 RDYYPMSSAQKRMYALYH--LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILR 920 +D Y ++ Q+ M L+H L+ E S+ + + +EG LDVG + L ++ R ++ R Sbjct: 10 QDMYLLTPMQEGM--LFHALLDEEHNSHLVQMSVSIEGNLDVGLYTNSLHVLVERFDVFR 67 Query: 921 TSF-HMIHHEPVQVVHDTIDFSIDYTEEKIDDIRLEADRFIQ--------PFDLDTSPLF 971 T F + +P+QVV I + + D + + R+ Q F L L Sbjct: 68 TLFLYEKLKQPLQVVMKERPIPILFCDLTAYDEQEKQQRYTQYKRNDQEKTFHLAKDSLM 127 Query: 972 RVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLY-----GNAVLPEPEIQFKDFS 1026 RV I ++ Y ++ HHI+ DG + +L +Y G + +P + F Sbjct: 128 RVAIFQMTESKYEIIWSFHHILMDGWCFSIIFDDLLSVYLSLKNGAPISLDPVQPYSQFI 187 Query: 1027 VWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRK 1086 W + + ++ L+ F+ + L + + ++ ++ F LD+ T++ Sbjct: 188 RWLGKQDKEAALAYWRDY-LEQFEQQTSLPR----FGKSSSNAFLPAQYRFVLDRMVTQQ 242 Query: 1087 LKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQ--VELESVMGMFSNTL 1144 L +A N TL ++ L+ I+L D++ GS V+ R V ++ ++G+F NT+ Sbjct: 243 LSAIASQNQVTLPTVIQTLWGILLQSYNTTNDVLFGSVVSGRPTEIVGIDKMVGLFINTI 302 Query: 1145 AMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTG-RNPLFDAMLIL 1203 R ++ F D + +V + Q Y E + DI D+ + L D ++++ Sbjct: 303 PFRVQAKNDQTFVDLIQDVHQRTRQS---QPY---EHVPLYDIQNDSVLKQDLIDHLMVI 356 Query: 1204 QNIAV----------NQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYCTR 1253 +N + Q F + V +E + +D+T+ + + + F+Y Sbjct: 357 ENYPLVEALQKKAETRQVCFAIVNVEMFEP----TNYDMTVMVMPKEE--IAMRFDYNAA 410 Query: 1254 LFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILAFN-QTSFDLPADQTI 1312 +F ++ M +LK I V + + + + +++E QQ++A N TS P +T+ Sbjct: 411 VFDDAFIQKMAGHLKQIATWVANNPRVNLQQVTLLTETEKQQLMARNLDTSAAYPT-KTM 469 Query: 1313 HGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFE 1372 H LF EQ +R D A+ F +Q ++Y EL++++NQLAR LR KG+ A S+VG M +RS E Sbjct: 470 HELFMEQVERTPDHVAVVFGEQHLTYRELDEKSNQLARFLRGKGIAADSLVGTMMDRSIE 529 Query: 1373 MMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNC 1432 M++G LG+LK+GGA++PIDP+ P ERI +M+E SGIQ V+TQ L E ID++ Sbjct: 530 MIVGILGVLKAGGAFVPIDPELPEERIAYMLEHSGIQWVVTQQHLLEKLSASTETIDISA 589 Query: 1433 AGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRE 1492 + +++ +IN+ DL Y+IYTSGTTGKPKG +LEH+ + NL + I E Sbjct: 590 PAIWEESSASVEMINQPEDLFYIIYTSGTTGKPKGVMLEHQNMANLMHFTFAKTNIDFHE 649 Query: 1493 RVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYL 1552 +V+Q+++ SFDV +I ++L GG L L T E+ + AF+ N+I+ LP ++L Sbjct: 650 KVLQYTTCSFDVCYQEIFSTLLSGGQLYLITNEMRRNVEKLFAFIQENQISILSLPVSFL 709 Query: 1553 ------ANLNPNNIHTVDKMITIGSA-ISSGLVNEWKRKCEYI--NAYGPTETTVYSSVW 1603 + + V +IT G + + + ++ R N YGP+ET V ++ + Sbjct: 710 KFIFNEKDYAQSFPRCVKHIITAGEQLVVTHELQKYLRNHHVFLHNHYGPSETHVVTT-Y 768 Query: 1604 IANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTA 1663 + ++ + PIGKPI NT +YILD+ L+P GI GEL I G + RGY PE+TA Sbjct: 769 TMDPSMDIPELPPIGKPISNTGIYILDEKLQLKPEGIVGELYISGANVGRGYLHNPELTA 828 Query: 1664 DKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEG 1723 +K + ++YRTGDLARW+PDGN+E+LGR+D QVKIRG R+E EI++ LL Sbjct: 829 EKFLENPYQSGERMYRTGDLARWMPDGNIEFLGRIDHQVKIRGHRIELGEIESHLLNHAL 888 Query: 1724 IKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTS 1783 IK+ +V R ++ +CAY + A + S ELR L LPE+MIP++F+++E P+T Sbjct: 889 IKEAVVIDRTDETGGKYLCAYVVLAEEVSNEELRAYLSRTLPEYMIPSFFMKLERIPVTP 948 Query: 1784 NGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSL 1843 NGK D++ LP+PE + + Y+ P E+E +A +WE VL + +GI+DNFF +GG SL Sbjct: 949 NGKTDRRALPIPEGNAFTGADYLAPTTELEQKMAAIWESVLGVSPIGIQDNFFTLGGHSL 1008 Query: 1844 KAMQVAAILGKH-RLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSSGTEGDA 1902 KA+ + + + K + + ++ LF R I E+++ V EG+ Sbjct: 1009 KAIHLISRMQKDCQTDVPLRVLFDRPTIQEIAKYV---------------------EGEE 1047 Query: 1903 SIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHTSIPFRSCGD 1962 + L + ++ QE S + L+ L A Y+L + + + Sbjct: 1048 AGTYLA---IPQVTMQEHYPVSSAQKRMLILNQLDPASTVYNLPVVTVLDGEL------N 1098 Query: 1963 IGKIQKAILRLVNEQVLLRSVIVNDGENTYFYEHGSVYNLPFILIDLSGFDAAR-RSEC- 2020 + +++ AI LV+ LR T F+ ++G R EC Sbjct: 1099 VPQMENAISGLVSRHESLR---------TSFH-------------TINGELVQRIHPECK 1136 Query: 2021 --LAYLQDHFNKL---------PFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSL 2069 +AY++ N+L PF+ + L R+ LV+ ++++ H +SDG+S Sbjct: 1137 LPIAYMEATENRLNQVITDFMRPFDLEKAPLSRVGLVKLGERRHVMIIDMHHIISDGVSS 1196 Query: 2070 GIITDQLAAYFAGDSSLPVHSLKHHQNYWDYA 2101 II + LA + D SLP ++ Y D+A Sbjct: 1197 QIILNDLAQLYQ-DKSLPEQRIQ----YKDFA 1223 Score = 496 bits (1276), Expect = e-137, Method: Compositional matrix adjust. Identities = 336/1094 (30%), Positives = 542/1094 (49%), Gaps = 73/1094 (6%) Query: 14 TSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKE-SLRLDIPDGLFQQLQHLSN 71 + + KK+++YW + G + I TD P EG + L D P Sbjct: 2268 SDDFKKQEEYWRHAFEGHNSVLEIPTDFPRPPVKSFEGDQIVLATDRPLLEALHALAAET 2327 Query: 72 RSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYNHYVPIIDTF------ 125 ++ +L+ +LL A L+ K+T I V +P+ + E PI+ F Sbjct: 2328 KT--TLFMVLLAAYNVLLSKYTGQDDIVVGTPISGKTRAELE------PIVGMFVNTLAI 2379 Query: 126 ----TTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDR------DFSFV---- 171 T TF+E L++V++ L AYDHQDYP + ++E + D D F+ Sbjct: 2380 RNKPTAEKTFKEFLMEVKQNALDAYDHQDYPLESLVEKLGIQRDPGRNPLFDTMFILQTD 2439 Query: 172 ---RHVLCLLT--NIHNDAVIPDVGSNIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAK 226 + L LT + + ++ F T + + L L Y+ K F R+ V ++++ Sbjct: 2440 ELYQKTLGQLTYHPYEPTSALAISKFDLSFHLTERETDLLLRLEYSTKLFRRDTVDRMSR 2499 Query: 227 QYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRT-YQNMEDMTLYELFEKQVRQTP 285 + QIL+ A +L ++ T + ED T+ +LFE+ V TP Sbjct: 2500 HFMQILRNVAAEPDRQLQAIEMLTAEEKQLLLVEFNHTDREYTEDQTIQQLFEELVANTP 2559 Query: 286 DHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSG 345 D A+ F + +TY +LN +AN+LA VLR +G+G +QIV ++VERS++M L ILK+G Sbjct: 2560 DQTAIVFEEKQMTYEELNERANQLATVLREKGLGPSQIVVMMVERSLEMVIATLAILKAG 2619 Query: 346 AAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLD 405 A+LP+D PEER++++IED+ ++ +++ K+ +I L D ++D Sbjct: 2620 GAFLPVDPDYPEERIRYMIEDSQAKLVLTHSHLIHKVSSQA-EIIDLGDAESYSAQTDNL 2678 Query: 406 LILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIF 465 L + + D AY+IYTSGTTG PKGV++EH+ +N K+ + DR S F Sbjct: 2679 LCINKPSDL-AYIIYTSGTTGNPKGVMLEHKGAANLQAMFKNHFGVTPQDRPGHFASISF 2737 Query: 466 DGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPE 525 D + F +++GAT+ + D + + + IT + +P Y+ L +P+ Sbjct: 2738 DASVWDMFMALLTGATLYIISRDTINDFRKFEEYVHKNGIT-ILTLPPTYAIYL---EPD 2793 Query: 526 EAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDL--KPDDTEL 583 SLRI+ AG + L+ +Q + +N YGPTES++ AT + L +P + Sbjct: 2794 RMPSLRILITAGSAASTALV---EQWKEKVTYINAYGPTESTICATTWKALPHEPVGQTI 2850 Query: 584 TIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANE 643 TIGKPI NT+++IV + ++LK G +GELCISG LARGY + LT +KFV NPF E Sbjct: 2851 TIGKPIQNTKLFIVDEQMQLKTVGQIGELCISGVALARGYWNRPELTAEKFVDNPFVPGE 2910 Query: 644 RMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQ 703 +MYRTGDLA+W G IE +GR D QVK+RG+R+ELGE+E+ LL Y I EAV D Sbjct: 2911 KMYRTGDLAKWLPDGNIEYLGRIDHQVKVRGHRVELGEVESVLLRYETIVEAVAITHLDD 2970 Query: 704 NDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNN 763 +CAY V D S +LRE + K LP YM+P+ F Q+++ P+TP K+DR AL Sbjct: 2971 LGQPYLCAYYVADGAASPAQLREFMGKELPNYMVPSFFVQMDKMPLTPNDKIDRKALPKP 3030 Query: 764 QDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKE 823 ++ G ++ P NE+E L W VL + +V + DNFF LGG S+KA + +RLH Sbjct: 3031 SHEEKPGREYEAPQNELEHLLATTWAEVLGIGQVGMKDNFFELGGDSIKAIQVSTRLHAA 3090 Query: 824 FQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSA--QKRMYALYHL 881 + + E+F+ TI +AA + + ++ E D P+ ++ +H Sbjct: 3091 GWT-LAMKELFQYPTIEQVAAHVIPNNRESDQGVVEGEI-DLTPIQKWFFERNFTDRHH- 3147 Query: 882 EGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFS 941 +N ++ E D G V+ +++ H+ LR + + Q+ Sbjct: 3148 ------WNQAVMLFREDGFDPGLVQQAFYKIVEHHDALRMIYKQENETITQINRALTGER 3201 Query: 942 IDYTEEKIDD-------IRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIIS 994 + + D I ++ DL+ PL + + +L + +HH++ Sbjct: 3202 FRFHSYDLKDHANSAAHIWELSNHIQSSIDLEQGPLVHLALFSTTEGDHL-LIAIHHLVV 3260 Query: 995 DGISIGLFIKELALLYGNA------VLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKM 1048 DG+S + ++ + Y A VLP+ FKD+S + AE+ + ++ +W + Sbjct: 3261 DGVSWRILFEDFSSAYSQALHNQEIVLPKKTDSFKDWSAQLQNYAESDELLREAAYWHNL 3320 Query: 1049 FKGEVPLLELPVDY 1062 + +LP D+ Sbjct: 3321 -ESTATAEKLPTDF 3333 >C0ZDA7.1 C0ZDA7_BREBN Tyrocidine synthetase III Length = 6487 Score = 1450 bits (3754), Expect = 0.0, Method: Compositional matrix adjust. Identities = 773/1912 (40%), Positives = 1157/1912 (60%), Gaps = 63/1912 (3%) Query: 9 NVLLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDG--LFQQ 65 N T E ++ YW++ G + TD P S EG+ RL G L ++ Sbjct: 2257 NQWYETDEFTAQEAYWIDTFTGEIPVLNLATDYPRPSVKSFEGE---RLVFGSGALLKKE 2313 Query: 66 LQHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYNHYVPIIDTF 125 L L++ + +LY +LL A L+ K++ I V +P ++ +++ II F Sbjct: 2314 LNRLAHSTGATLYMVLLAAYHVLLSKYSGQEDIVVGAPTAGRSHAETDS------IIGMF 2367 Query: 126 TTGM----------TFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVL 175 + TF L +V+ TL A+++QDYP D++I+ + D + + + Sbjct: 2368 VNTLALRNEPVGTKTFLSFLAEVKNNTLKAFENQDYPLDELIDKLNIQRDLSRNPLFDTV 2427 Query: 176 CLLTNIHND-------------AVIPDVGSNIVFGFTRDDAGISLNLIYNLKYFTRNFVM 222 +L N+ A + ++ +D I +L Y K FTR + Sbjct: 2428 FILQNMDQKPFEMEQLTFTPYMAEVNQAKFDLSLEAYEEDEEIVFSLDYCTKLFTRKTIE 2487 Query: 223 QLAKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNM-EDMTLYELFEKQV 281 +A + +IL E +I L + + ++ ++ TL+ELFE+QV Sbjct: 2488 NIAAHFIRILHAVIEQQAIPLSEITMLSAEEKHRLLVEFNQMHKEYPQNKTLHELFEEQV 2547 Query: 282 RQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGI 341 +TP A++ + ++YR+LN +AN+LA LR +GV ANQ VG++ RS++M GI+ I Sbjct: 2548 EKTPLVAAIEIGGKQMSYRELNERANQLAVTLRERGVKANQFVGIMANRSMEMVVGIMAI 2607 Query: 342 LKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLE-- 399 LK+G AY+P+D + PE+R+ +++ED + +++K KL + +R++ L E Sbjct: 2608 LKAGGAYVPIDPEYPEDRVAYMLEDCEARLVLTHKHLGAKLA----SSVRVECLYLEEEH 2663 Query: 400 ----NESDLDLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASD 455 N S+L+ I + AY+IYTSGTTG+PKGV+IEHR I N++ W+K EY F D Sbjct: 2664 NYSPNRSNLEPI--QTASDLAYLIYTSGTTGKPKGVMIEHRGIVNSVLWKKEEYQFSVQD 2721 Query: 456 RMLQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLY 515 R L S+ FDGF+ SFFTPI+SG+T V + + EA+DPL++ +LI + T VP+L+ Sbjct: 2722 RNLVPLSFAFDGFVLSFFTPILSGSTAVLVKDEEAKDPLSLRRLIAAARCTQMTCVPSLF 2781 Query: 516 SALLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRD 575 A+L + SL+ VTL GEKV+ L+ S + +P + I NEYGPTESSV+AT +R Sbjct: 2782 QAILECGSAADISSLQTVTLGGEKVSAQLVEKSNKQNPQLVIANEYGPTESSVVATWQRI 2841 Query: 576 LKPDDTELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFV 635 + D T +TIG+PI NT +YIV +L+ G+VGE+CI G GLARGY + LT +KFV Sbjct: 2842 SQLDST-ITIGRPIANTSIYIVDKFHQLQPIGVVGEICIGGHGLARGYWNKPELTAEKFV 2900 Query: 636 SNPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEA 695 S+P+ ERMY+TGDL +W G IE IGR D QVK+RGYRIE+GEIE+ +L Y + A Sbjct: 2901 SHPYLEGERMYKTGDLGKWLPDGTIEFIGRLDEQVKVRGYRIEIGEIESVMLSYEKLISA 2960 Query: 696 VVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKM 755 VV + EDQ S + AY + L +L LSKSLP YM+P H QL+ P+TP GK+ Sbjct: 2961 VVIVHEDQQGQSSLAAYYTAEEKLEVSKLWSYLSKSLPSYMIPAHLVQLDFLPLTPNGKL 3020 Query: 756 DRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATM 815 DR AL + GA + P + +ESRLVEIW++VL V + + DNFF LGGHSLKA Sbjct: 3021 DRKALPKPEGRPVTGAEYVAPASPLESRLVEIWEHVLGVTDIGVLDNFFQLGGHSLKAMS 3080 Query: 816 LLSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRM 875 L +++H+E+QVE+ L +F TI LA+ I++ T+ I P ++YYP+SSAQKRM Sbjct: 3081 LAAQIHREYQVELPLSVLFATPTIQALASYIETSGKDTHVPIHPAPWQEYYPVSSAQKRM 3140 Query: 876 YALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVH 935 + L EG ST YNMP VM +EG+LD + E+ ++++I RHE LRTSFH ++ EPVQ VH Sbjct: 3141 FVLRQFEGTSTVYNMPSVMFIEGDLDHARFETAIQELIKRHESLRTSFHTVNGEPVQRVH 3200 Query: 936 DTIDFSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISD 995 + ++ ++ Y + D + + F+Q FDL+ +PL RV + ++A +LF+ DMHHIISD Sbjct: 3201 EAVELNVRYEDLTEDQVEQTIETFVQAFDLEKAPLLRVGLFRLAENRHLFLMDMHHIISD 3260 Query: 996 GISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPL 1055 G+S+G+ ++E + Y N +LPE IQ+KDF+VW+ + + + + E +WLK F G++P+ Sbjct: 3261 GVSVGIIMEEFSKFYRNQLLPELSIQYKDFAVWQTDLFQTDIYTKHENYWLKSFAGDIPV 3320 Query: 1056 LELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITN 1115 L LP DY RP+ +S+EG I F DK L +LA +N TL+M+LLA +N++LSK + Sbjct: 3321 LNLPADYSRPLVQSFEGDCISFHTDKTLMDDLYKLAHENQTTLFMVLLAAYNVLLSKYSG 3380 Query: 1116 QEDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQD 1175 QEDI+VG+P+ R ++E V+GMF NTLA+RN+P G K F+ FL +VK + L A+ +QD Sbjct: 3381 QEDIVVGTPIAGRSHADVEKVLGMFVNTLALRNYPDGTKSFQAFLEDVKQNTLQAYAHQD 3440 Query: 1176 YQFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFY--EHEHNISRFDIT 1233 Y FE ++ KL+I RD RNPLFD M ILQN+ ++ +K Y + + ++FD+T Sbjct: 3441 YPFEALVEKLEIQRDLSRNPLFDTMFILQNLDKKAYELDGLKFEAYSGDGQQGNAKFDLT 3500 Query: 1234 LHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAV 1293 L E G +H S Y T+LF R+T+E M + ++ VIAD+ + +I ++ E Sbjct: 3501 LEAHEDETG-IHFSLVYSTKLFHRDTMERMAGHFLQVLRGVIADQTAALHEIDLLGEEEK 3559 Query: 1294 QQI-LAFNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLL 1352 + +AFN T P + TI LFEEQ KR + A+ +Q ++Y ELN++ANQ+A +L Sbjct: 3560 HLVTVAFNNTFAAYPRESTIQELFEEQVKRTPEHAAVVMNEQMLTYWELNQKANQIASVL 3619 Query: 1353 REKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVL 1412 R V SVVG++ +RS EM+ G +GI+K+GGAYL IDP++P ERI +M+ED G+++VL Sbjct: 3620 RRLEVGRDSVVGMLADRSLEMITGIMGIIKAGGAYLGIDPEHPAERISYMLEDGGVKVVL 3679 Query: 1413 TQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEH 1472 Q + ++ I L L D SNL +N + DLAY++YTSG+TGKPKG ++EH Sbjct: 3680 VQRHLLHLVEEGLIPIILEDESLEQADASNLTNLNDAKDLAYVMYTSGSTGKPKGVMVEH 3739 Query: 1473 KGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSC 1532 + + L + +++++ +R++Q +I FD +I ++L G +L L +K++L D Sbjct: 3740 RNVTRLV-KHTNYVQVREEDRMIQTGAIGFDAMTFEIFGALLHGASLFLVSKDVLLDAEK 3798 Query: 1533 FEAFLNSNRITAAIL-PPTY--LANLNPNNIHTVDKMITIGSAISS---GLVNEWKRKCE 1586 +FL NRIT L P + L+ NP + +I G A+S VN E Sbjct: 3799 LGSFLRENRITTMWLTSPLFNQLSQNNPAMFEGLRALIVGGEALSPRHINKVNSAHPALE 3858 Query: 1587 YINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCI 1646 N YGPTE T +S+ ++ K E +D +PIGKPI N+ YI+D+Y QP+G+PGELC+ Sbjct: 3859 IWNGYGPTENTTFSTCYLIEK--EFEDNIPIGKPITNSTAYIVDRYNQPQPIGVPGELCV 3916 Query: 1647 GGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRG 1706 GG G+ RGY +PE+TA+K + +YRTGDLARW DG +EYLGR+D+QVKIRG Sbjct: 3917 GGDGVARGYLNKPELTAEKFVPNPFVLGENMYRTGDLARWKADGTIEYLGRIDQQVKIRG 3976 Query: 1707 FRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPE 1766 +R+E EI+ L +E +K+ +VT + ++CAY++S + V ELR+ + +LP Sbjct: 3977 YRIELGEIETVLTNLEKVKEAVVTVLDDTNGQKALCAYFVSEEELDVVELREAISKELPS 4036 Query: 1767 FMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRL 1826 +M+PA++V+ME PLT+NGK++++ LP P + S Y+ P+N E LAE+W+EVL + Sbjct: 4037 YMVPAFYVQMEKLPLTANGKVNRRALPEPSGDRVQGSTYVAPQNATEQKLAEIWQEVLGI 4096 Query: 1827 EKVGIEDNFFEVGGDSLKAMQVAAILGK-HRLHMEIKDLFHRQKIAELSECV 1877 +GI DNFFE+GG SLKAM V + K ++ + +K LF I EL+ + Sbjct: 4097 HPIGIHDNFFELGGHSLKAMNVITQVHKAFQVELPLKALFETPTIHELAAYI 4148 Score = 1368 bits (3540), Expect = 0.0, Method: Compositional matrix adjust. Identities = 774/2131 (36%), Positives = 1200/2131 (56%), Gaps = 102/2131 (4%) Query: 1 MSIQNANINV----LLSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRL 56 +SIQ + V L T K + YWL G + D + + + + Sbjct: 3283 LSIQYKDFAVWQTDLFQTDIYTKHENYWLKSFAGDIPVLNLPADYSRPLVQSFEGDCISF 3342 Query: 57 DIPDGLFQQLQHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTS 112 L L L++ + +L+ +LL A L+ K++ I V +P+ + D Sbjct: 3343 HTDKTLMDDLYKLAHENQTTLFMVLLAAYNVLLSKYSGQEDIVVGTPIAGRSHADVEKVL 3402 Query: 113 EAYNHYVPIIDTFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVR 172 + + + + + +F+ L V++ TL AY HQDYPF+ ++E ++ D + + Sbjct: 3403 GMFVNTLALRNYPDGTKSFQAFLEDVKQNTLQAYAHQDYPFEALVEKLEIQRDLSRNPLF 3462 Query: 173 HVLCLLTNIHNDAVIPD-----------VGSNIVFGFT----RDDAGISLNLIYNLKYFT 217 + +L N+ A D N F T D+ GI +L+Y+ K F Sbjct: 3463 DTMFILQNLDKKAYELDGLKFEAYSGDGQQGNAKFDLTLEAHEDETGIHFSLVYSTKLFH 3522 Query: 218 RNFVMQLAKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNM-EDMTLYEL 276 R+ + ++A + Q+L+G + + L + T+ + T+ EL Sbjct: 3523 RDTMERMAGHFLQVLRGVIADQTAALHEIDLLGEEEKHLVTVAFNNTFAAYPRESTIQEL 3582 Query: 277 FEKQVRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAG 336 FE+QV++TP+H AV N Q +TY +LN KAN++A VLR VG + +VG+L +RS++M Sbjct: 3583 FEEQVKRTPEHAAVVMNEQMLTYWELNQKANQIASVLRRLEVGRDSVVGMLADRSLEMIT 3642 Query: 337 GILGILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDV 396 GI+GI+K+G AYL +D + P ER+ +++ED G++V + + L +GL I L+D+ Sbjct: 3643 GIMGIIKAGGAYLGIDPEHPAERISYMLEDGGVKVVLVQRHLLH-LVEEGLIPIILEDES 3701 Query: 397 LLENESDLDLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDR 456 L + ++ L A D AYV+YTSG+TG+PKGV++EHR+++ ++ + DR Sbjct: 3702 LEQADASNLTNLNDAKDL-AYVMYTSGSTGKPKGVMVEHRNVTRLVK-HTNYVQVREEDR 3759 Query: 457 MLQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYS 516 M+Q + FD F ++ GA++ + + D + + ++IT L++ Sbjct: 3760 MIQTGAIGFDAMTFEIFGALLHGASLFLVSKDVLLDAEKLGSFLRENRITTMWLTSPLFN 3819 Query: 517 ALLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDL 576 L +N P + LR + + GE ++P + HP +EI N YGPTE++ +T Sbjct: 3820 QLSQN-NPAMFEGLRALIVGGEALSPRHINKVNSAHPALEIWNGYGPTENTTFSTCYLIE 3878 Query: 577 KPDDTELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVS 636 K + + IGKPI N+ YIV + + G+ GELC+ G G+ARGYL+ LT +KFV Sbjct: 3879 KEFEDNIPIGKPITNSTAYIVDRYNQPQPIGVPGELCVGGDGVARGYLNKPELTAEKFVP 3938 Query: 637 NPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAV 696 NPF E MYRTGDLARW G IE +GR D QVK+RGYRIELGEIE L + EAV Sbjct: 3939 NPFVLGENMYRTGDLARWKADGTIEYLGRIDQQVKIRGYRIELGEIETVLTNLEKVKEAV 3998 Query: 697 VALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMD 756 V + +D N +CAY V + L +ELRE++SK LP YM+P + Q+E+ P+T GK++ Sbjct: 3999 VTVLDDTNGQKALCAYFVSEEELDVVELREAISKELPSYMVPAFYVQMEKLPLTANGKVN 4058 Query: 757 RNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATML 816 R AL + G+ + P N E +L EIW+ VL + + IHDNFF LGGHSLKA + Sbjct: 4059 RRALPEPSGDRVQGSTYVAPQNATEQKLAEIWQEVLGIHPIGIHDNFFELGGHSLKAMNV 4118 Query: 817 LSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMY 876 ++++HK FQVE+ L +FE TI LAA I + + +I P E D+YP+S AQKRMY Sbjct: 4119 ITQVHKAFQVELPLKALFETPTIHELAAYITASEMEQFETIQPVEHADFYPVSFAQKRMY 4178 Query: 877 ALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHD 936 L+ EG SYN+P VM+++G LD + E +R ++ RHE LRTSFH + EPVQ VH+ Sbjct: 4179 ILHEFEGSGISYNVPNVMIIDGHLDYERFEYAIRTLVKRHESLRTSFHSKNGEPVQRVHE 4238 Query: 937 TIDFSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDG 996 + I +E D + +QPFDL+ +PLFRV +IK+ + +LF DMHHIISDG Sbjct: 4239 DVTLLIGISEATDDQVEQRIQELVQPFDLEVAPLFRVDLIKLGAERHLFFMDMHHIISDG 4298 Query: 997 ISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLL 1056 +S+ + KE A LY LP+ IQ+KDF+ W+ + A++ F++QE++W +F GE+PLL Sbjct: 4299 VSLAVIAKEFASLYEKNQLPDMRIQYKDFAAWQTKLAQSERFQKQEDYWTNVFAGELPLL 4358 Query: 1057 ELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQ 1116 LP D+ RP +S+EG + +L++LA + G+TL+M+LLA +N++LSK T Q Sbjct: 4359 NLPNDFPRPTVQSFEGDTVAIGTGNHLLAELRQLAANTGSTLFMVLLAAYNVLLSKYTGQ 4418 Query: 1117 EDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDY 1176 E+I+VG+P+ R ++E ++GMF NTLA++N G+ F++FL +VK +AL AF++QDY Sbjct: 4419 EEIVVGTPIAGRSHADVERIVGMFVNTLALKNVAGGDLTFREFLGDVKQNALHAFEHQDY 4478 Query: 1177 QFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHC 1236 FE ++ KL + RD RNPLFD M L + + + +S Y + I++FDI L Sbjct: 4479 PFEHLVDKLQVRRDLSRNPLFDTMFSLGLADSSALEIAGLNMSAYPVDGKIAKFDIALDA 4538 Query: 1237 LEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQI 1296 +E D LL F YCT+LF +E+++ M + ++ +IA+ + ++++I ++S++ ++Q+ Sbjct: 4539 MEQQDELL-VQFSYCTKLFAKESIDRMATHYIHLLQTIIANPDRKLAEISVLSKDEMEQM 4597 Query: 1297 LA-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREK 1355 L FN T+ P ++T LFEEQ ++ ++ A+ D+ ++Y ELN++ANQLAR+LR+ Sbjct: 4598 LHDFNATNVAYPTNKTFQELFEEQVEKTPNQVAVICEDEQLTYRELNEKANQLARVLRQM 4657 Query: 1356 GVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQN 1415 GV S VG+M +RS M++G LGILK+GGAY+PIDPDYP ER F++EDS +L LT Sbjct: 4658 GVKPESTVGIMVDRSLHMVVGTLGILKAGGAYVPIDPDYPLERQAFILEDSDAKLFLTLQ 4717 Query: 1416 IPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGI 1475 L F E + L+ GL + SNL + AY+IYTSGTTGKPKG ++EH+ Sbjct: 4718 KMNTQLVFPYETLYLDAEGLYQGEASNLEPVALPEHAAYIIYTSGTTGKPKGVVIEHRSY 4777 Query: 1476 VNLTASNKEQLKIQDRE-RVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFE 1534 N+ + +++ + R++Q +S +FDVS D + ++L GG L + E+ D + Sbjct: 4778 ANVAFAWQDEYHLDTFPVRLLQMASFAFDVSTGDFARALLTGGQLVICPNEVKMDPASLY 4837 Query: 1535 AFLNSNRIT------AAILPPTYLANLNPNNIHTVDKMITIGSAISSG-----LVNEWKR 1583 + IT A I+P + N +I + K++ +G+ S L+ + Sbjct: 4838 EIIKRYEITIFEATPALIMPLMHYIYENKLDISQM-KLLILGADSCSAEDFKTLLTRFSH 4896 Query: 1584 KCEYINAYGPTETTVYSSVWIANKQGEV-DDPVPIGKPILNTQMYILDKYRNLQPVGIPG 1642 +N+YG TE + SS + + VPIGKP+ N QMY++D+ NLQPVG+ G Sbjct: 4897 TLRIVNSYGVTEACIDSSYYEETDVSSIRSGTVPIGKPLPNMQMYVMDQQLNLQPVGVVG 4956 Query: 1643 ELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQV 1702 ELCIGG G+ RGY RPE+T +K + + +YRTGDLA+W DGN+E+LGR D QV Sbjct: 4957 ELCIGGAGVARGYLNRPELTVEKFVPNPFAPGELLYRTGDLAKWRADGNMEFLGRNDHQV 5016 Query: 1703 KIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLS 1762 KIRG R+E EI+ +L K++GI + +V R++ Q +CAY ++ + ++RKQLL Sbjct: 5017 KIRGVRIELGEIETQLRKLDGILEAVVVAREDHRQEKYLCAYMVADHEIDTAQVRKQLLK 5076 Query: 1763 KLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEE 1822 +LP+ MIP+YFV +EA PLT+NGKID++ LPVP+ S+ R + Y+ PR E+E LA VWE+ Sbjct: 5077 ELPQAMIPSYFVTLEALPLTANGKIDRRSLPVPDVSLLRTTEYVAPRTELEAQLARVWEQ 5136 Query: 1823 VLRLEKVGIEDNFFEVGGDSLKAMQV-AAILGKHRLHMEIKDLFHRQKIAELSECVRDLR 1881 VL +E+VG+ D+FF +GG SL+AM V +++ ++++ + ++ LF + I +L+ + + Sbjct: 5137 VLNVEQVGVLDDFFAIGGHSLRAMSVISSMHNEYQVDIPLRVLFEKPTIQQLAAYIEETA 5196 Query: 1882 NNPIVENPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQ 1941 ++ SI+ AP G + ++ Q Sbjct: 5197 KEYVI--------------------------------------SIKPAPAQGYYPVSSAQ 5218 Query: 1942 K--YHLMNAEKVHTSIPFRSCGDI-GKIQKAILRLVNEQVLLR------SVIVNDGENTY 1992 K Y L E V S S I GK++ L +Q++ R S V +GE Sbjct: 5219 KRMYILHQFEGVGISYNMPSTMLIEGKLEPERLETAFKQLIARHESLRTSFAVVNGEPVQ 5278 Query: 1993 FYEHGSVYNLPFILIDLSGFDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPED 2052 + L + I + E L+ L PF+ L R+ L+Q + Sbjct: 5279 KIHEEVSFELSYTTI-----TEDQAQEVLSSLVQ-----PFDLGVAPLLRVRLLQIGEDR 5328 Query: 2053 YMLLYSADHAVSDGLSLGIITDQLAAYFAGD 2083 ++L H++SDG+S GI+ L + GD Sbjct: 5329 HVLFTDTHHSISDGVSSGILLSDLVQLYQGD 5359 Score = 1348 bits (3488), Expect = 0.0, Method: Compositional matrix adjust. Identities = 768/2144 (35%), Positives = 1206/2144 (56%), Gaps = 107/2144 (4%) Query: 9 NVLLSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRLDIPDGLFQQLQH 68 N L T KK++ +WLN + TD + + + + D L ++L+ Sbjct: 1220 NELFQTDVYKKQELHWLNTFADEIPLLNLPTDYPRPTIQSFAGDLVLFDTGKELTERLRK 1279 Query: 69 LSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPIIDT 124 ++ + +LY +LL A L+ K++ I V +PV + D S + + + + + Sbjct: 1280 VAGDTSTTLYMVLLAAYHVLLSKYSGQEDIIVGTPVAGRSHADVESIMGIFVNTLAMRNQ 1339 Query: 125 FTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHND 184 + TF + L +V++ L AYD+QDYPF++++E + D + + + L N + Sbjct: 1340 PVSDKTFTQFLQEVKQNALAAYDNQDYPFEELVEKLAIQRDISRNPLFDTMFSLENANQQ 1399 Query: 185 AV-IPDVGS------------NIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQI 231 ++ I + + ++ + + I + K F + + ++A Y +I Sbjct: 1400 SLKIEQLTAAPYELFNKISKFDLALNASESQSDIHFQFAFGTKLFAKETIQKMAHHYLEI 1459 Query: 232 LKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTY-QNMEDMTLYELFEKQVRQTPDHVAV 290 L+ + KL + T+ + D L++LFE+QV TPD VAV Sbjct: 1460 LRTICAQPNAKLAEIDMMTEAEKRALLLNVNDTFVERSADQVLHQLFEEQVVLTPDQVAV 1519 Query: 291 KFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLP 350 ++ ++TYR LNA+AN++AR+LR++G + ++G++V+RSI+M +L +LK+G AY P Sbjct: 1520 AYDGYTLTYRQLNARANQVARMLRSKGTQPDTLIGIMVDRSIEMVVSMLAVLKAGGAYTP 1579 Query: 351 LDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLE-NESDLDLILG 409 +D P ER+Q+++ D+ + ++ + +E ++ G +I +DD+ + ++++LD + G Sbjct: 1580 MDPTYPPERIQYMLSDSKAPILLTQRHLKETVEYTG-EIIDVDDEAIYAGDDTNLDNVAG 1638 Query: 410 RALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDGFL 469 R D AYVIYTSG+TG PKGV+I H++I N + W K+ + D +LQ + FD + Sbjct: 1639 R--DDLAYVIYTSGSTGNPKGVMISHQAICNHMLWMKNAFPLLTEDAVLQKTPFSFDASV 1696 Query: 470 TSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEAQS 529 F+ P+++GA +V RD + ++I KIT VP+L ++ S Sbjct: 1697 WEFYLPLITGARLVLAKPDGHRDIAYMTRMIREEKITTLQMVPSLLDLIMTEPGWSSCTS 1756 Query: 530 LRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLK-PDDTELTIGKP 588 L+ V GE +T L+ Q +++N YGPTES++ AT + P+ + + IGKP Sbjct: 1757 LQRVFCGGEALTAALVSRFYQTQTA-QLINLYGPTESTIDATYWICPRLPEHSVIPIGKP 1815 Query: 589 IGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERMYRT 648 I N R+Y+V + +L+ G+ GELCI+G GLARGY + E LT F+ NPFE RMYRT Sbjct: 1816 IDNVRLYVVNASNQLQPVGVAGELCIAGDGLARGYWNREELTEASFIDNPFEPGSRMYRT 1875 Query: 649 GDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNSR 708 GD+ R+ G +E +GR D QVK+RG+RIELGEIE RLL++ I A+V D+ + Sbjct: 1876 GDMVRYLACGNVEYLGRIDHQVKIRGHRIELGEIEARLLQHEWIKTAIVLARPDEKGQNN 1935 Query: 709 ICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLKE 768 + AYIV D+ + +LR L+ LP YM+P++F LE+ P+T GK+DR AL + Sbjct: 1936 LYAYIVSDQEMKTADLRAYLASHLPSYMVPSYFVYLEKLPLTANGKVDRKALPQPEGAST 1995 Query: 769 LGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVEI 828 + P NE+E+ LV+IW++VL + + +HD+FF LGGHSLKA ++S +H+ QV++ Sbjct: 1996 SEIVYVAPRNEVEATLVDIWQSVLGQNPIWVHDHFFELGGHSLKAMNVISLIHRTLQVDV 2055 Query: 829 ELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGESTSY 888 L +FE TI +L+A I + G Y++I P +K++YY +SSAQKRM+ L +EG SY Sbjct: 2056 PLKTLFESPTIADLSAYIATAGKGKYTTIEPVQKQEYYSVSSAQKRMFILRQMEGAGISY 2115 Query: 889 NMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYTEEK 948 NMP ++ ++G+LD +++ L+ ++ RHE LRTSFH + E VQ VH+ ++ I E Sbjct: 2116 NMPGILYIDGKLDTERLQQALKSVVRRHESLRTSFHSMKGETVQRVHEDVELDISLMEST 2175 Query: 949 IDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELAL 1008 +++ ++FIQPFDL+ +PL R ++K+A +LFM D+HHI+ DG+SIG+ ++ELA Sbjct: 2176 EGELKQIVEQFIQPFDLEKAPLMRAGLVKLAPERHLFMLDLHHIVVDGVSIGILVQELAQ 2235 Query: 1009 LYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHK 1068 LY LPE IQ+KDF+ W+ + E +F QE +W+ F GE+P+L L DY RP K Sbjct: 2236 LYHGEELPELSIQYKDFAHWQNQWYETDEFTAQEAYWIDTFTGEIPVLNLATDYPRPSVK 2295 Query: 1069 SYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRR 1128 S+EG ++ F ++L LA GATLYM+LLA ++++LSK + QEDI+VG+P R Sbjct: 2296 SFEGERLVFGSGALLKKELNRLAHSTGATLYMVLLAAYHVLLSKYSGQEDIVVGAPTAGR 2355 Query: 1129 RQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIV 1188 E +S++GMF NTLA+RN P G K F FL EVK++ L AF+NQDY +E+I KL+I Sbjct: 2356 SHAETDSIIGMFVNTLALRNEPVGTKTFLSFLAEVKNNTLKAFENQDYPLDELIDKLNIQ 2415 Query: 1189 RDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCSF 1248 RD RNPLFD + ILQN+ F+ ++ + Y E N ++FD++L E D + S Sbjct: 2416 RDLSRNPLFDTVFILQNMDQKPFEMEQLTFTPYMAEVNQAKFDLSLEAYEE-DEEIVFSL 2474 Query: 1249 EYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILA-FNQTSFDLP 1307 +YCT+LF R+T+E + + I++ VI + I +S+I M+S ++L FNQ + P Sbjct: 2475 DYCTKLFTRKTIENIAAHFIRILHAVIEQQAIPLSEITMLSAEEKHRLLVEFNQMHKEYP 2534 Query: 1308 ADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMF 1367 ++T+H LFEEQ ++ A+E + MSY ELN+RANQLA LRE+GV A VG+M Sbjct: 2535 QNKTLHELFEEQVEKTPLVAAIEIGGKQMSYRELNERANQLAVTLRERGVKANQFVGIMA 2594 Query: 1368 ERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEV 1427 RS EM++G + ILK+GGAY+PIDP+YP +R+ +M+ED +LVLT L Sbjct: 2595 NRSMEMVVGIMAILKAGGAYVPIDPEYPEDRVAYMLEDCEARLVLTHKHLGAKL---ASS 2651 Query: 1428 IDLNCAGLN-----NMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASN 1482 + + C L + + SNL I +SDLAY+IYTSGTTGKPKG ++EH+GIVN Sbjct: 2652 VRVECLYLEEEHNYSPNRSNLEPIQTASDLAYLIYTSGTTGKPKGVMIEHRGIVNSVLWK 2711 Query: 1483 KE--QLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSN 1540 KE Q +QDR V S +FD ++ IL G T L E D + + Sbjct: 2712 KEEYQFSVQDRNLVPL--SFAFDGFVLSFFTPILSGSTAVLVKDEEAKDPLSLRRLIAAA 2769 Query: 1541 RITA-AILPPTYLANLNPNNIHTVDKMITI---GSAISSGLV---NEWKRKCEYINAYGP 1593 R T +P + A L + + + T+ G +S+ LV N+ + N YGP Sbjct: 2770 RCTQMTCVPSLFQAILECGSAADISSLQTVTLGGEKVSAQLVEKSNKQNPQLVIANEYGP 2829 Query: 1594 TETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTR 1653 TE++V ++ W + ++D + IG+PI NT +YI+DK+ LQP+G+ GE+CIGG GL R Sbjct: 2830 TESSVVAT-W--QRISQLDSTITIGRPIANTSIYIVDKFHQLQPIGVVGEICIGGHGLAR 2886 Query: 1654 GYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQE 1713 GYW +PE+TA+K ++ ++Y+TGDL +WLPDG +E++GR+DEQVK+RG+R+E E Sbjct: 2887 GYWNKPELTAEKFVSHPYLEGERMYKTGDLGKWLPDGTIEFIGRLDEQVKVRGYRIEIGE 2946 Query: 1714 IKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYF 1773 I++ +L E + +V ++Q +S+ AYY + V++L L LP +MIPA+ Sbjct: 2947 IESVMLSYEKLISAVVIVHEDQQGQSSLAAYYTAEEKLEVSKLWSYLSKSLPSYMIPAHL 3006 Query: 1774 VRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIED 1833 V+++ PLT NGK+D+K LP PE + Y+ P + +E L E+WE VL + +G+ D Sbjct: 3007 VQLDFLPLTPNGKLDRKALPKPEGRPVTGAEYVAPASPLESRLVEIWEHVLGVTDIGVLD 3066 Query: 1834 NFFEVGGDSLKAMQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRI 1893 NFF++GG SLKAM +AA + HR+ EL V L P ++ I Sbjct: 3067 NFFQLGGHSLKAMSLAAQI-------------HREYQVELPLSV--LFATPTIQALASYI 3111 Query: 1894 DSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHT 1953 ++SG D + + + W QE S + V + Y++ + + Sbjct: 3112 ETSGK--DTHVPIHPAPW------QEYYPVSSAQKRMFVLRQFEGTSTVYNMPSVMFIEG 3163 Query: 1954 SIPFRSCGDIGKIQKAILRLVNEQVLLR-SVIVNDGENTYFYEHGSVYNLPFILIDLSGF 2012 + D + + AI L+ LR S +GE N+ + DL+ Sbjct: 3164 DL------DHARFETAIQELIKRHESLRTSFHTVNGEPVQRVHEAVELNVRY--EDLTED 3215 Query: 2013 DAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGII 2072 + E F+ + L R+ L + A ++ L H +SDG+S+GII Sbjct: 3216 QVEQTIETFVQ--------AFDLEKAPLLRVGLFRLAENRHLFLMDMHHIISDGVSVGII 3267 Query: 2073 TDQLAAYFAGDSSLPVHSLKH------------------HQNYW 2098 ++ + ++ + LP S+++ H+NYW Sbjct: 3268 MEEFSKFYR-NQLLPELSIQYKDFAVWQTDLFQTDIYTKHENYW 3310 Score = 1259 bits (3257), Expect = 0.0, Method: Compositional matrix adjust. Identities = 712/1915 (37%), Positives = 1102/1915 (57%), Gaps = 62/1915 (3%) Query: 11 LLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQHL 69 L + +K++ YW N G + D P + EG +++ + + L +L+ L Sbjct: 4334 LAQSERFQKQEDYWTNVFAGELPLLNLPNDFPRPTVQSFEG-DTVAIGTGNHLLAELRQL 4392 Query: 70 SNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPIIDTF 125 + + +L+ +LL A L+ K+T I V +P+ + D + + + + + Sbjct: 4393 AANTGSTLFMVLLAAYNVLLSKYTGQEEIVVGTPIAGRSHADVERIVGMFVNTLALKNVA 4452 Query: 126 TTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQA--------ISDRDFSF-VRHVLC 176 +TFRE L V++ L A++HQDYPF+ +++ +Q + D FS + Sbjct: 4453 GGDLTFREFLGDVKQNALHAFEHQDYPFEHLVDKLQVRRDLSRNPLFDTMFSLGLADSSA 4512 Query: 177 LLTNIHNDAVIPDVGSNIVFGFTRDDAGISLNLIYNLKYFTRNFVMQ----LAKQYFQIL 232 L N + P G F D L+ Y T+ F + +A Y +L Sbjct: 4513 LEIAGLNMSAYPVDGKIAKFDIALDAMEQQDELLVQFSYCTKLFAKESIDRMATHYIHLL 4572 Query: 233 KGAAENVSIKLGSMXXXXXXXXXXXXXXQTRT-YQNMEDMTLYELFEKQVRQTPDHVAVK 291 + N KL + T + T ELFE+QV +TP+ VAV Sbjct: 4573 QTIIANPDRKLAEISVLSKDEMEQMLHDFNATNVAYPTNKTFQELFEEQVEKTPNQVAVI 4632 Query: 292 FNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLPL 351 ++ +TYR+LN KAN+LARVLR GV VG++V+RS+ M G LGILK+G AY+P+ Sbjct: 4633 CEDEQLTYRELNEKANQLARVLRQMGVKPESTVGIMVDRSLHMVVGTLGILKAGGAYVPI 4692 Query: 352 DIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENE-SDLDLILGR 410 D P ER F++ED+ ++ ++ ++ +L T + LD + L + E S+L+ + Sbjct: 4693 DPDYPLERQAFILEDSDAKLFLTLQKMNTQLVFPYET-LYLDAEGLYQGEASNLEPV--- 4748 Query: 411 AL-DHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASD-RMLQLFSYIFDGF 468 AL +H AY+IYTSGTTG+PKGV+IEHRS +N + EY D R+LQ+ S+ FD Sbjct: 4749 ALPEHAAYIIYTSGTTGKPKGVVIEHRSYANVAFAWQDEYHLDTFPVRLLQMASFAFDVS 4808 Query: 469 LTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPE--E 526 F +++G +V DP ++ ++I ++IT F A P L L+ + + Sbjct: 4809 TGDFARALLTGGQLVICPNEVKMDPASLYEIIKRYEITIFEATPALIMPLMHYIYENKLD 4868 Query: 527 AQSLRIVTLAGEKVTP-NLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTE--- 582 ++++ L + + + + + IVN YG TE+ + ++ + Sbjct: 4869 ISQMKLLILGADSCSAEDFKTLLTRFSHTLRIVNSYGVTEACIDSSYYEETDVSSIRSGT 4928 Query: 583 LTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEAN 642 + IGKP+ N ++Y++ L L+ G+VGELCI GAG+ARGYL+ LT +KFV NPF Sbjct: 4929 VPIGKPLPNMQMYVMDQQLNLQPVGVVGELCIGGAGVARGYLNRPELTVEKFVPNPFAPG 4988 Query: 643 ERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWED 702 E +YRTGDLA+W G +E +GR D QVK+RG RIELGEIE +L + +GI EAVV ED Sbjct: 4989 ELLYRTGDLAKWRADGNMEFLGRNDHQVKIRGVRIELGEIETQLRKLDGILEAVVVARED 5048 Query: 703 QNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRN 762 +CAY+V D + ++R+ L K LP+ M+P++F LE P+T GK+DR +L Sbjct: 5049 HRQEKYLCAYMVADHEIDTAQVRKQLLKELPQAMIPSYFVTLEALPLTANGKIDRRSLPV 5108 Query: 763 NQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHK 822 + P E+E++L +W+ VL V++V + D+FF +GGHSL+A ++S +H Sbjct: 5109 PDVSLLRTTEYVAPRTELEAQLARVWEQVLNVEQVGVLDDFFAIGGHSLRAMSVISSMHN 5168 Query: 823 EFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLE 882 E+QV+I L +FEK TI LAA I+ SI P + YYP+SSAQKRMY L+ E Sbjct: 5169 EYQVDIPLRVLFEKPTIQQLAAYIEETAKEYVISIKPAPAQGYYPVSSAQKRMYILHQFE 5228 Query: 883 GESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSI 942 G SYNMP M++EG+L+ ++E+ +Q+I+RHE LRTSF +++ EPVQ +H+ + F + Sbjct: 5229 GVGISYNMPSTMLIEGKLEPERLETAFKQLIARHESLRTSFAVVNGEPVQKIHEEVSFEL 5288 Query: 943 DYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLF 1002 YT D + +QPFDL +PL RV++++I ++ D HH ISDG+S G+ Sbjct: 5289 SYTTITEDQAQEVLSSLVQPFDLGVAPLLRVRLLQIGEDRHVLFTDTHHSISDGVSSGIL 5348 Query: 1003 IKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDY 1062 + +L LY VLPE IQ++DFSVW++E + F +QE +W ++F E+P+L L D+ Sbjct: 5349 LSDLVQLYQGDVLPELRIQYRDFSVWQQELFRSDAFNKQEHYWAQVFADEIPVLNLQTDF 5408 Query: 1063 KRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVG 1122 RP +++ G + K+ L +LA + G TLYM+LLA +N++LSK + QEDIIVG Sbjct: 5409 TRPSIQNFAGDQYSIGTGKQLMEGLNQLARETGTTLYMVLLATYNVLLSKYSGQEDIIVG 5468 Query: 1123 SPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMI 1182 +P+T R +LE ++GMF NTLAMRN P K F + L EVK +AL A+ +QDY FEE++ Sbjct: 5469 TPITGRSHADLEPIVGMFVNTLAMRNKPHAGKTFTELLLEVKQNALDAYAHQDYPFEELV 5528 Query: 1183 SKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFY--EHEHNISRFDITLHCLEGL 1240 KLDI RD RNPLFD M +QN + N + ++ + + N S+FD+TL E Sbjct: 5529 EKLDIPRDLSRNPLFDTMFTVQNNSDNAIDLHGLTLAPFMTDQAGNHSKFDLTLIATEER 5588 Query: 1241 DGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AF 1299 + + EY T LF RET+E + ++ AI V+ + IR+S+I M+ +QI +F Sbjct: 5589 EE-IRIGVEYSTSLFTRETIERLSNHFMAIAQIVVQNPHIRLSEIDMLKAEEKKQIFESF 5647 Query: 1300 NQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTA 1359 N T+ + D+T+H LFEEQ + ++ A+ F Q+++Y +LN++AN+LAR+LR KGV Sbjct: 5648 NDTAVNYVQDKTLHQLFEEQVAKTPNQEAILFNGQSLTYSKLNEQANRLARVLRTKGVGP 5707 Query: 1360 GSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYN 1419 +V +M ERS EM+IG LGILK+GGAY+PIDP YP ERI++++ DS L+L Q+ Sbjct: 5708 DRLVAVMAERSPEMIIGILGILKAGGAYVPIDPAYPQERIQYLLADSNAALLLCQSHLSE 5767 Query: 1420 WLDFDGEVID---LNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIV 1476 L +D L+ +DGSNL +N+ +DLAY+IYTSGTTGKPKG ++ H+GIV Sbjct: 5768 LLSRVSSGLDWLELSAKHDVEIDGSNLSSLNQPTDLAYVIYTSGTTGKPKGVMIPHRGIV 5827 Query: 1477 NLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAF 1536 N +++ ++ +Q S +FD + + +L G T L +E D + Sbjct: 5828 NCLQWRRDEYGFGPGDKALQVFSFAFDGFVASLFAPLLGGATCVLPREEEAKDPVALKKL 5887 Query: 1537 LNSNRIT---------AAILPPTYLANLNPNNIHTVDKMITIGSAISSGLVNEWKRK--- 1584 + S +T AIL + A+ +P T+ G + + LV + K K Sbjct: 5888 IASAGVTHYYGVPSLFQAILDCSTAADFSPLRCVTLG-----GEKLPAQLVQKTKEKHPA 5942 Query: 1585 CEYINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGEL 1644 E N YGPTE +V +++ ++ E + IG+P+ N Q+YI+D +LQP+G+ GEL Sbjct: 5943 IEINNEYGPTENSVVTTI---SRSIEAGQDITIGRPLANVQVYIVDTQHHLQPIGVVGEL 5999 Query: 1645 CIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKI 1704 CIGG GL +GY +PE+T +K + +Y+TGDL +W DG ++Y+GR DEQVK+ Sbjct: 6000 CIGGPGLAKGYLNKPELTQEKFVPNPFVPGELMYKTGDLVKWRADGTIDYIGRADEQVKV 6059 Query: 1705 RGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHAS-ICAYYISAMDYSVTELRKQLLSK 1763 RG+R+E EI++ +L +GI +V ++++L +CAY + A + SV+ELR+ L + Sbjct: 6060 RGYRIEIGEIESTILAYDGIDQAVVVVQEDELTAGQYLCAYLVPAAEVSVSELRRHLTKE 6119 Query: 1764 LPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEV 1823 LP +M+P+YFV+++ PL++NGK+D+K LP P+ S ++ PR IE LA +W+EV Sbjct: 6120 LPAYMVPSYFVQLDQLPLSANGKVDRKALPKPKPSDATTREFVAPRTAIEYQLAAIWQEV 6179 Query: 1824 LRLEKVGIEDNFFEVGGDSLKA-MQVAAILGKHRLHMEIKDLFHRQKIAELSECV 1877 L ++ +GI D+FFE+GG SLKA + VA + ++ + + +F I ++++ + Sbjct: 6180 LGIDPIGITDHFFELGGHSLKATLLVAKVYEYMQIELPLNLIFQHPTIEKVADFI 6234 Score = 1228 bits (3178), Expect = 0.0, Method: Compositional matrix adjust. Identities = 685/1858 (36%), Positives = 1063/1858 (57%), Gaps = 78/1858 (4%) Query: 270 DMTLYELFEKQVRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVE 329 D T++EL +Q RQTP AV +TY++L ++N+LAR LR +G+ IV ++ E Sbjct: 463 DKTIFELIAEQARQTPSKAAVICGEDRLTYQELQERSNQLARALRGKGITQGSIVSIMAE 522 Query: 330 RSIDMAGGILGILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTV 389 S+++ I+ +LKSG AYLP+D + P ER+Q+L++D+ ++ ++ +EK++ +G + Sbjct: 523 HSLELIVAIMAVLKSGGAYLPIDPEYPIERIQYLLDDSQTKILLTQSHLQEKVEFEG-DI 581 Query: 390 IRLDDDVLLENESDLDLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEY 449 + LD+ L E +S DL D AY+IYTSG+TG PKG +I H+ + N I W EY Sbjct: 582 LYLDNPSLFEGDST-DLDNSCKPDDLAYMIYTSGSTGNPKGAMITHQGLVNYIWWANKEY 640 Query: 450 -SFDASDRMLQLFSYI-FDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITH 507 +A D L+S I FD +TS FTP++SG T+ D + +I I Sbjct: 641 VQGEAVD--FPLYSSISFDLTITSIFTPLLSGNTIYVY---RGADKVQVILDIIQDNQVG 695 Query: 508 FIAVPTLYSALLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPG----MEIVNEYGP 563 I + + L+ + + S+R + GE + L +K+++ ++I NEYGP Sbjct: 696 IIKLTPTHLKLIEEIDGTNS-SIRRFIVGGENLPTKL---AKRIYENFGQNVKIFNEYGP 751 Query: 564 TESSV--LATLKRDLKPDDTELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLAR 621 TE+ V + L KP + IG P N ++Y++ +++ G GE+ I+G G+A+ Sbjct: 752 TETVVGCMIYLYDPKKPIQESVPIGVPADNVQLYLLDSSMQPIPVGSAGEMYIAGDGVAK 811 Query: 622 GYLHNEVLTRDKFVSNPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGE 681 GY + LT +KF+ NPF +MYRTGDLA+W G +E +GR D QVK+RG+RIE+GE Sbjct: 812 GYFNRPELTEEKFIDNPFRPGTKMYRTGDLAKWLPDGNMEYVGRIDHQVKIRGHRIEMGE 871 Query: 682 IENRLLEYNGITEAVVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHF 741 IE RL ++ I EAVV +D + + + AY+V ++ L+ ELRE L +LP YM+P+ F Sbjct: 872 IETRLAQHEWIKEAVVIAEKDDSGQNVLYAYMVSEQELTVSELREHLGSTLPSYMIPSFF 931 Query: 742 FQLEQFPMTPTGKMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHD 801 +LE+ P+T GK++R L G + P NE E++L EIW+ VL V +V +HD Sbjct: 932 VRLEEIPLTANGKVERKKLPKPDGAVVTGTAYVAPQNETETKLAEIWQQVLGVSRVGVHD 991 Query: 802 NFFMLGGHSLKATMLLSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTE 861 +FF LGGHSLKA ++ ++ K +V++ + +FE T+ LAA + Y++I P E Sbjct: 992 HFFDLGGHSLKAMTVIFQVSKALEVDLPVKALFENPTVSELAAFLSKSGKSKYTAIQPVE 1051 Query: 862 KRDYYPMSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRT 921 +++YP+SSAQKRMY L EG SYN+ M++EG+LD + + ++++ RHE LRT Sbjct: 1052 VKEFYPVSSAQKRMYILQQFEGSGISYNISGAMLLEGKLDYDRFANTVKRLAERHEALRT 1111 Query: 922 SFHMIHHEPVQVVHDTIDFSI---DYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKI 978 SFH I EPVQ VH+ ++ I TE+K + I + F++PFDL +PL R ++++ Sbjct: 1112 SFHRIDGEPVQKVHEEVEVPILMLTSTEDKAEQIMRD---FVRPFDLGIAPLIRTGLVQL 1168 Query: 979 ASRHYLFMFDMHHIISDGISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDF 1038 +LFM DMHHIISDG+S + + E A LY L +Q+KDF+ W+ E + + Sbjct: 1169 GEDRHLFMLDMHHIISDGVSSQILLSEFAKLYQGEALQPLSLQYKDFAAWQNELFQTDVY 1228 Query: 1039 KQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATL 1098 K+QE WL F E+PLL LP DY RP +S+ G + F KE T +L+++AGD TL Sbjct: 1229 KKQELHWLNTFADEIPLLNLPTDYPRPTIQSFAGDLVLFDTGKELTERLRKVAGDTSTTL 1288 Query: 1099 YMLLLALFNIMLSKITNQEDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKD 1158 YM+LLA ++++LSK + QEDIIVG+PV R ++ES+MG+F NTLAMRN P +K F Sbjct: 1289 YMVLLAAYHVLLSKYSGQEDIIVGTPVAGRSHADVESIMGIFVNTLAMRNQPVSDKTFTQ 1348 Query: 1159 FLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKV 1218 FL EVK +AL+A+DNQDY FEE++ KL I RD RNPLFD M L+N + ++ Sbjct: 1349 FLQEVKQNALAAYDNQDYPFEELVEKLAIQRDISRNPLFDTMFSLENANQQSLKIEQLTA 1408 Query: 1219 SFYEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADR 1278 + YE + IS+FD+ L+ E +H F + T+LF +ET++ M + I+ + A Sbjct: 1409 APYELFNKISKFDLALNASESQSD-IHFQFAFGTKLFAKETIQKMAHHYLEILRTICAQP 1467 Query: 1279 EIRISDICMVSENAVQQILA-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMS 1337 ++++I M++E + +L N T + ADQ +H LFEEQ D+ A+ + T++ Sbjct: 1468 NAKLAEIDMMTEAEKRALLLNVNDTFVERSADQVLHQLFEEQVVLTPDQVAVAYDGYTLT 1527 Query: 1338 YGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGE 1397 Y +LN RANQ+AR+LR KG +++G+M +RS EM++ L +LK+GGAY P+DP YP E Sbjct: 1528 YRQLNARANQVARMLRSKGTQPDTLIGIMVDRSIEMVVSMLAVLKAGGAYTPMDPTYPPE 1587 Query: 1398 RIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIY 1457 RI++M+ DS ++LTQ +++ GE+ID++ + D +NL + DLAY+IY Sbjct: 1588 RIQYMLSDSKAPILLTQRHLKETVEYTGEIIDVDDEAIYAGDDTNLDNVAGRDDLAYVIY 1647 Query: 1458 TSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGG 1517 TSG+TG PKG ++ H+ I N K + + V+Q + SFD S+ + + ++ G Sbjct: 1648 TSGSTGNPKGVMISHQAICNHMLWMKNAFPLLTEDAVLQKTPFSFDASVWEFYLPLITGA 1707 Query: 1518 TLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYL----ANLNPNNIHTVDKMITIGSAI 1573 L L + D + + +IT + P+ L ++ ++ ++ G A+ Sbjct: 1708 RLVLAKPDGHRDIAYMTRMIREEKITTLQMVPSLLDLIMTEPGWSSCTSLQRVFCGGEAL 1767 Query: 1574 SSGLVNEW--KRKCEYINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDK 1631 ++ LV+ + + + IN YGPTE+T+ ++ WI + E +PIGKPI N ++Y+++ Sbjct: 1768 TAALVSRFYQTQTAQLINLYGPTESTIDATYWICPRLPE-HSVIPIGKPIDNVRLYVVNA 1826 Query: 1632 YRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGN 1691 LQPVG+ GELCI G GL RGYW R E+T I ++YRTGD+ R+L GN Sbjct: 1827 SNQLQPVGVAGELCIAGDGLARGYWNREELTEASFIDNPFEPGSRMYRTGDMVRYLACGN 1886 Query: 1692 LEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDY 1751 +EYLGR+D QVKIRG R+E EI+A LL+ E IK IV R ++ ++ AY +S + Sbjct: 1887 VEYLGRIDHQVKIRGHRIELGEIEARLLQHEWIKTAIVLARPDEKGQNNLYAYIVSDQEM 1946 Query: 1752 SVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNE 1811 +LR L S LP +M+P+YFV +E PLT+NGK+D+K LP PE + Y+ PRNE Sbjct: 1947 KTADLRAYLASHLPSYMVPSYFVYLEKLPLTANGKVDRKALPQPEGASTSEIVYVAPRNE 2006 Query: 1812 IELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGKH-RLHMEIKDLFHRQKI 1870 +E L ++W+ VL + + D+FFE+GG SLKAM V +++ + ++ + +K LF I Sbjct: 2007 VEATLVDIWQSVLGQNPIWVHDHFFELGGHSLKAMNVISLIHRTLQVDVPLKTLFESPTI 2066 Query: 1871 AELSECVRDLRNNPIVENPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAP 1930 A+LS I ++G +IE ++ QE S + Sbjct: 2067 ADLS----------------AYIATAGKGKYTTIE--------PVQKQEYYSVSSAQKRM 2102 Query: 1931 LVGKHLPAAVQKYHLMNAEKVHTSIPFRSCGDIGKIQKAILRLVNEQVLLRSVIVNDGEN 1990 + + + A Y++ + + D ++Q+A+ +V LR+ + Sbjct: 2103 FILRQMEGAGISYNMPGILYIDGKL------DTERLQQALKSVVRRHESLRTSFHSMKGE 2156 Query: 1991 TYFYEHGSVYNLPFILIDLSGFDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAP 2050 T H V +D+S ++ L + + F + PF+ + L R LV+ AP Sbjct: 2157 TVQRVHEDVE------LDISLMESTEGE--LKQIVEQFIQ-PFDLEKAPLMRAGLVKLAP 2207 Query: 2051 EDYMLLYSADHAVSDGLSLGIITDQLAAYFAGDS----SLPVHSLKHHQNYWDYADQM 2104 E ++ + H V DG+S+GI+ +LA + G+ S+ H QN W D+ Sbjct: 2208 ERHLFMLDLHHIVVDGVSIGILVQELAQLYHGEELPELSIQYKDFAHWQNQWYETDEF 2265 Score = 595 bits (1535), Expect = e-167, Method: Compositional matrix adjust. Identities = 332/873 (38%), Positives = 499/873 (57%), Gaps = 47/873 (5%) Query: 11 LLSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRLDIPDGLFQQLQHLS 70 L + K++ YW + TD + ++ + + L + L L+ Sbjct: 5378 LFRSDAFNKQEHYWAQVFADEIPVLNLQTDFTRPSIQNFAGDQYSIGTGKQLMEGLNQLA 5437 Query: 71 NRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYNHYVPIIDTFT---- 126 + +LY +LL L+ K++ I V +P+ T ++ PI+ F Sbjct: 5438 RETGTTLYMVLLATYNVLLSKYSGQEDIIVGTPI------TGRSHADLEPIVGMFVNTLA 5491 Query: 127 ------TGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTN 180 G TF E LL+V++ L AY HQDYPF++++E + D + + + + N Sbjct: 5492 MRNKPHAGKTFTELLLEVKQNALDAYAHQDYPFEELVEKLDIPRDLSRNPLFDTMFTVQN 5551 Query: 181 IHNDAVIPDVGSNIVFGFTRDDAG-----------------ISLNLIYNLKYFTRNFVMQ 223 ++A+ D+ + F D AG I + + Y+ FTR + + Sbjct: 5552 NSDNAI--DLHGLTLAPFMTDQAGNHSKFDLTLIATEEREEIRIGVEYSTSLFTRETIER 5609 Query: 224 LAKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQN-MEDMTLYELFEKQVR 282 L+ + I + +N I+L + T N ++D TL++LFE+QV Sbjct: 5610 LSNHFMAIAQIVVQNPHIRLSEIDMLKAEEKKQIFESFNDTAVNYVQDKTLHQLFEEQVA 5669 Query: 283 QTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGIL 342 +TP+ A+ FN QS+TY LN +AN+LARVLR +GVG +++V ++ ERS +M GILGIL Sbjct: 5670 KTPNQEAILFNGQSLTYSKLNEQANRLARVLRTKGVGPDRLVAVMAERSPEMIIGILGIL 5729 Query: 343 KSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKR--DGLTVIRLDDDVLLEN 400 K+G AY+P+D P+ER+Q+L+ D+ + + E L R GL + L ++ Sbjct: 5730 KAGGAYVPIDPAYPQERIQYLLADSNAALLLCQSHLSELLSRVSSGLDWLELS----AKH 5785 Query: 401 ESDLDLILGRALDHP---AYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRM 457 + ++D +L+ P AYVIYTSGTTG+PKGV+I HR I N +QWR+ EY F D+ Sbjct: 5786 DVEIDGSNLSSLNQPTDLAYVIYTSGTTGKPKGVMIPHRGIVNCLQWRRDEYGFGPGDKA 5845 Query: 458 LQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSA 517 LQ+FS+ FDGF+ S F P++ GAT V E EA+DP+A+ +LI +TH+ VP+L+ A Sbjct: 5846 LQVFSFAFDGFVASLFAPLLGGATCVLPREEEAKDPVALKKLIASAGVTHYYGVPSLFQA 5905 Query: 518 LLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLK 577 +L + LR VTL GEK+ L+ +K+ HP +EI NEYGPTE+SV+ T+ R ++ Sbjct: 5906 ILDCSTAADFSPLRCVTLGGEKLPAQLVQKTKEKHPAIEINNEYGPTENSVVTTISRSIE 5965 Query: 578 PDDTELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSN 637 ++TIG+P+ N +VYIV L+ G+VGELCI G GLA+GYL+ LT++KFV N Sbjct: 5966 AGQ-DITIGRPLANVQVYIVDTQHHLQPIGVVGELCIGGPGLAKGYLNKPELTQEKFVPN 6024 Query: 638 PFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVV 697 PF E MY+TGDL +W G I+ IGRAD QVK+RGYRIE+GEIE+ +L Y+GI +AVV Sbjct: 6025 PFVPGELMYKTGDLVKWRADGTIDYIGRADEQVKVRGYRIEIGEIESTILAYDGIDQAVV 6084 Query: 698 ALWEDQ-NDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMD 756 + ED+ +CAY+V +S ELR L+K LP YM+P++F QL+Q P++ GK+D Sbjct: 6085 VVQEDELTAGQYLCAYLVPAAEVSVSELRRHLTKELPAYMVPSYFVQLDQLPLSANGKVD 6144 Query: 757 RNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATML 816 R AL + F P IE +L IW+ VL +D + I D+FF LGGHSLKAT+L Sbjct: 6145 RKALPKPKPSDATTREFVAPRTAIEYQLAAIWQEVLGIDPIGITDHFFELGGHSLKATLL 6204 Query: 817 LSRLHKEFQVEIELDEIFEKQTICNLAALIKSK 849 ++++++ Q+E+ L+ IF+ TI +A I K Sbjct: 6205 VAKVYEYMQIELPLNLIFQHPTIEKVADFITHK 6237 Score = 537 bits (1384), Expect = e-150, Method: Compositional matrix adjust. Identities = 381/1267 (30%), Positives = 653/1267 (51%), Gaps = 92/1267 (7%) Query: 866 YPMSSAQKRMYALYHL--EGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSF 923 YP++ Q+ M L+H + S++Y + ++G+ + E + ++I +E+LRT F Sbjct: 11 YPLTPLQEGM--LFHAVKDTGSSAYCLQMSAKLQGDFQLSIFEKSMNKLIENYEVLRTVF 68 Query: 924 -HMIHHEPVQVVHDTIDFSIDY-------TEEKIDDIRLEADRFIQPFDLDTSPLFRVKI 975 + P QVV ++ + +++ D I+ ++ F+L L + I Sbjct: 69 VYQNLQRPRQVVFKERKVTVHFENIAHLPIDDQNDYIKAYTNQ-QHTFELTKDVLMKAAI 127 Query: 976 IKIASRHYLFMFDMHHIISDGISIGLFIKEL-----ALLYGNAVLPEPEIQFKDFSVW-E 1029 + + Y F++ HHII DG S+G+ + +L A+ G AV E + ++ W + Sbjct: 128 FQTEANQYQFVWAFHHIIVDGWSLGVLLHKLLGYYAAIRKGEAVPREATKPYSEYIKWLD 187 Query: 1030 KESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKE 1089 K++ E + +W K +G + P +Y + FT+ E T++L + Sbjct: 188 KQNKE-----EALTYWQKYLEGYDHQADFPKKKNVAEDGNYVHVENLFTIAPEKTQQLMQ 242 Query: 1090 LAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQ--VELESVMGMFSNTLAMR 1147 +A N AT+ + +L+ I+ SK N +D++ GS V+ R +ES++G+F NT+ R Sbjct: 243 IANRNQATMSSVFQSLWGILASKYKNSDDVVFGSVVSGRPPGIQGIESMVGLFINTIPTR 302 Query: 1148 NFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNIA 1207 + F + V+ AL++ E+ SK + + L D ++ +N Sbjct: 303 VQTNRKQTFSGLVKTVQKQALASAAYDFAPLYEIQSKTVL-----KQELIDHLVTYENYP 357 Query: 1208 VNQFQFGEMKVSF---YEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMI 1264 + E + F E+ + +D + ++ Y +++ + + Sbjct: 358 DDASNDREDSLGFQFNVENGEEQTSYDFNVVVAVAPSNEMYVKLSYNAAVYEESFMNRVE 417 Query: 1265 DYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSFDLPADQTIHGLFEEQAKRR 1323 +LK I+ QVI + + ++DI ++++ QQ+L A+N T+ D P D+TI L EQA++ Sbjct: 418 GHLKTIIEQVIHNPNVLLNDIGIITDEEKQQLLVAYNDTTADYPRDKTIFELIAEQARQT 477 Query: 1324 GDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKS 1383 + A+ + ++Y EL +R+NQLAR LR KG+T GS+V +M E S E+++ + +LKS Sbjct: 478 PSKAAVICGEDRLTYQELQERSNQLARALRGKGITQGSIVSIMAEHSLELIVAIMAVLKS 537 Query: 1384 GGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNL 1443 GGAYLPIDP+YP ERI+++++DS +++LTQ+ ++F+G+++ L+ L D ++L Sbjct: 538 GGAYLPIDPEYPIERIQYLLDDSQTKILLTQSHLQEKVEFEGDILYLDNPSLFEGDSTDL 597 Query: 1444 PVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVN-LTASNKEQLKIQDRERVVQFSSISF 1502 + DLAYMIYTSG+TG PKG ++ H+G+VN + +NKE ++ + + + +SSISF Sbjct: 598 DNSCKPDDLAYMIYTSGSTGNPKGAMITHQGLVNYIWWANKEYVQGEAVDFPL-YSSISF 656 Query: 1503 DVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYLA---NLNPNN 1559 D+++ I +L G T+ + + + N++ L PT+L ++ N Sbjct: 657 DLTITSIFTPLLSGNTIYVYRGA--DKVQVILDIIQDNQVGIIKLTPTHLKLIEEIDGTN 714 Query: 1560 IHTVDKMITIGSAISSGLVNE----WKRKCEYINAYGPTETTVYSSVWIANKQGEVDDPV 1615 ++ + I G + + L + + + N YGPTET V +++ + + + + V Sbjct: 715 -SSIRRFIVGGENLPTKLAKRIYENFGQNVKIFNEYGPTETVVGCMIYLYDPKKPIQESV 773 Query: 1616 PIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRIG 1675 PIG P N Q+Y+LD PVG GE+ I G G+ +GY+ RPE+T +K I Sbjct: 774 PIGVPADNVQLYLLDSSMQPIPVGSAGEMYIAGDGVAKGYFNRPELTEEKFIDNPFRPGT 833 Query: 1676 KVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQ 1735 K+YRTGDLA+WLPDGN+EY+GR+D QVKIRG R+E EI+ L + E IK+ +V K+ Sbjct: 834 KMYRTGDLAKWLPDGNMEYVGRIDHQVKIRGHRIEMGEIETRLAQHEWIKEAVVIAEKDD 893 Query: 1736 LQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVP 1795 + AY +S + +V+ELR+ L S LP +MIP++FVR+E PLT+NGK+++K LP P Sbjct: 894 SGQNVLYAYMVSEQELTVSELREHLGSTLPSYMIPSFFVRLEEIPLTANGKVERKKLPKP 953 Query: 1796 ENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGKH 1855 + ++ + Y+ P+NE E LAE+W++VL + +VG+ D+FF++GG SLKAM V Sbjct: 954 DGAVVTGTAYVAPQNETETKLAEIWQQVLGVSRVGVHDHFFDLGGHSLKAMTV------- 1006 Query: 1856 RLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSSGTEGDASIEVLCSIWLGEI 1915 +F K E+ V+ L NP V + SG +I+ + E+ Sbjct: 1007 --------IFQVSKALEVDLPVKALFENPTVSELAAFLSKSGKSKYTAIQPV------EV 1052 Query: 1916 KDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHTSIPFRSCGDIGKIQKAILRLVN 1975 K E S + + + + Y++ A + + D + + RL Sbjct: 1053 K--EFYPVSSAQKRMYILQQFEGSGISYNISGAMLLEGKL------DYDRFANTVKRLAE 1104 Query: 1976 EQVLLRSVIVN-DGENTYFYEHGSVYNLPFILIDLSGFDAARRSECLAYLQDHFNKLPFE 2034 LR+ DGE H V +P IL+ S D A + ++D PF+ Sbjct: 1105 RHEALRTSFHRIDGEPVQKV-HEEV-EVP-ILMLTSTEDKAEQ-----IMRDFVR--PFD 1154 Query: 2035 RDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQLAAYFAGDSSLPVHSLKHH 2094 L R LVQ + ++ + H +SDG+S I+ + A + G++ P+ SL+ Sbjct: 1155 LGIAPLIRTGLVQLGEDRHLFMLDMHHIISDGVSSQILLSEFAKLYQGEALQPL-SLQ-- 1211 Query: 2095 QNYWDYA 2101 Y D+A Sbjct: 1212 --YKDFA 1216 >O30409.1 TYCC_BREPA Tyrocidine synthetase 3 ATP-dependent asparagine adenylase ATP-dependent glutamine adenylase ATP-dependent tyrosine adenylase ATP-dependent valine adenylase ATP-dependent ornithine adenylase ATP-dependent leucine adenylase Length = 6486 Score = 1442 bits (3732), Expect = 0.0, Method: Compositional matrix adjust. Identities = 748/1899 (39%), Positives = 1144/1899 (60%), Gaps = 41/1899 (2%) Query: 12 LSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRLDIPDGLFQQLQHLSN 71 T E +++ YWLN G + TD + ++ + L +QL L+ Sbjct: 2260 FQTEEFAEQEAYWLNTFTGEIPVLNLPTDYPRPSVKSFAGDRFVFGSGTALPKQLHQLAQ 2319 Query: 72 RSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEA----YNHYVPIIDTFTT 127 + +LY +LL A L+ K++ I V +P ++ +E+ + + + + + Sbjct: 2320 ETGTTLYMVLLAAYNVLLSKYSRQEDIIVGAPTAGRSHAETESIVGMFVNTLALRNEPAG 2379 Query: 128 GMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHN---- 183 G TFR+ L +V+ TLGA++HQDYP D++++ + D + + + +L N+ Sbjct: 2380 GKTFRDFLAEVKINTLGAFEHQDYPLDELVDKLDMQRDLSRNPLFDTVFILQNMEQKPFE 2439 Query: 184 ---------DAVIPDVGSNIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQILKG 234 A + ++ ++A I +L Y+ K F+R + ++A + QIL+ Sbjct: 2440 MEQLTITPYSAEVKQAKFDLSLEAYEENAEIIFSLDYSTKLFSRETIEKIATHFIQILRA 2499 Query: 235 AAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNM-EDMTLYELFEKQVRQTPDHVAVKFN 293 + L + +++ ++ TL LFE+Q ++P AV+ + Sbjct: 2500 VIAEPEMPLSEITMLTEAEKQRLLVDFNGAHKDFPQNKTLQALFEEQAEKSPQATAVEIS 2559 Query: 294 NQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLPLDI 353 Q ++Y++LN +AN+LA LR +GV +Q VG++ RS++M GIL ILK+G AY+P+D Sbjct: 2560 GQPLSYQELNERANQLAATLRERGVQPDQPVGIMANRSVEMVVGILAILKAGGAYVPIDP 2619 Query: 354 KSPEERLQFLIEDAGIEVAVSNKQTEEKLKRD-GLTVIRLDDDVLLE-NESDLDLILGRA 411 + PEER+ +++ D + ++ K KL + LDD+ + S+L I Sbjct: 2620 EYPEERVAYMLTDCQARLVLTQKHLGAKLGSSVTAECLYLDDESNYGVHRSNLQPI--NT 2677 Query: 412 LDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDGFLTS 471 AY+IYTSGTTG+PKGV++EHR I N + W+K+EY DR L S+ FD F+ S Sbjct: 2678 ASDLAYIIYTSGTTGKPKGVMVEHRGIVNNVLWKKAEYQMKVGDRSLLSLSFAFDAFVLS 2737 Query: 472 FFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEAQSLR 531 FFTP++SGATVV ++ EA+DP+++ +LI + T VP+L+ A+L P + + L+ Sbjct: 2738 FFTPVLSGATVVLAEDEEAKDPVSLKKLIAASRCTLMTGVPSLFQAILECSTPADIRPLQ 2797 Query: 532 IVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELTIGKPIGN 591 VTL GEK+T L+ KQL+P + IVNEYGPTESSV+AT +R PD +TIG+PI N Sbjct: 2798 TVTLGGEKITAQLVEKCKQLNPDLVIVNEYGPTESSVVATWQRLAGPD-AAITIGRPIAN 2856 Query: 592 TRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERMYRTGDL 651 T +YIV +L+ G+VGE+CI G GLARGY + LT +KFVS+PF A ERMY+TGDL Sbjct: 2857 TSLYIVNQYHQLQPIGVVGEICIGGRGLARGYWNKPALTEEKFVSHPFAAGERMYKTGDL 2916 Query: 652 ARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNSRICA 711 +W G IE IGR D QVK+RGYRIE+GEIE+ LL +T AVV ++EDQ S + A Sbjct: 2917 GKWLPDGTIEYIGRIDEQVKVRGYRIEIGEIESALLAAEKLTAAVVVVYEDQLGQSALAA 2976 Query: 712 YIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLKELGA 771 Y D L +L LSK LP YM+P HF QL+Q P+TP GK+D+ AL + A Sbjct: 2977 YFTADEQLDVTKLWSHLSKRLPSYMIPAHFVQLDQLPLTPNGKVDKKALPKPEGKPVTEA 3036 Query: 772 RFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVEIELD 831 ++ PTN +ES+L EIW+ VL V + I DNFF +GGHSLKA + +++H+E+QVE+ L Sbjct: 3037 QYVAPTNAVESKLAEIWERVLGVSGIGILDNFFQIGGHSLKAMAVAAQVHREYQVELPLK 3096 Query: 832 EIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGESTSYNMP 891 +F + TI LA + + TY I P ++YYP+SSAQKRMY L T YNMP Sbjct: 3097 VLFAQPTIKALAQYVATSGKETYVPIEPAPLQEYYPVSSAQKRMYVLRQFADTGTVYNMP 3156 Query: 892 EVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYTEEKIDD 951 + +EG+LD + E+ + ++ RHE LRTSFH ++ EPVQ VH+ ++ ++ Y E Sbjct: 3157 SALYIEGDLDRKRFEAAIHGLVERHESLRTSFHTVNGEPVQRVHEHVELNVQYAEVTEAQ 3216 Query: 952 IRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLYG 1011 + + F+Q FDL +PL RV + K+A++ +LF+ DMHHIISDG+S G+ ++E + LY Sbjct: 3217 VEPTVESFVQAFDLTKAPLLRVGLFKLAAKRHLFLLDMHHIISDGVSAGIIMEEFSKLYR 3276 Query: 1012 NAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYE 1071 LP + +KDF+VW+ E ++ + + E +WL F G++P+L LP D+ RP+ +S+E Sbjct: 3277 GEELPALSVHYKDFAVWQSELFQSDVYTEHENYWLNAFSGDIPVLNLPADFSRPLTQSFE 3336 Query: 1072 GSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQV 1131 G + F DK L +LA ++ +TL+M+LLA +N++L+K + QEDI+VG+P+ R Sbjct: 3337 GDCVSFQADKALLDDLHKLAQESQSTLFMVLLAAYNVLLAKYSGQEDIVVGTPIAGRSHA 3396 Query: 1132 ELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDT 1191 ++E+V+GMF NTLA+RN+P K F+ FL EVK + L A+ +QDY FE ++ KLDI RD Sbjct: 3397 DIENVLGMFVNTLALRNYPVETKHFQAFLEEVKQNTLQAYAHQDYPFEALVEKLDIQRDL 3456 Query: 1192 GRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYC 1251 RNPLFD M ILQN+ ++ +K+ Y + ++FD+TL E G +H + Y Sbjct: 3457 SRNPLFDTMFILQNLDQKAYELDGLKLEAYPAQAGNAKFDLTLEAHEDETG-IHFALVYS 3515 Query: 1252 TRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQI-LAFNQTSFDLPADQ 1310 T+LF+RE++E M + ++ QV+AD+ + +I ++SE + + + FN T P D Sbjct: 3516 TKLFQRESIERMAGHFLQVLRQVVADQATALREISLLSEEERRIVTVDFNNTFAAYPRDL 3575 Query: 1311 TIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERS 1370 TI LFE+QA + + A+ Q ++Y ELN++ANQLA +LR+ GV S+VGL+ +RS Sbjct: 3576 TIQELFEQQAAKTPEHAAVVMDGQMLTYRELNEKANQLAHVLRQNGVGKESIVGLLADRS 3635 Query: 1371 FEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGE---V 1427 EM+ G +GILK+GGAYL +DP++P ER+ +M+ED G+++VL Q + L GE Sbjct: 3636 LEMITGIMGILKAGGAYLGLDPEHPSERLAYMLEDGGVKVVLVQK---HLLPLVGEGLMP 3692 Query: 1428 IDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLK 1487 I L L D N ++N +SDLAY++YTSG+TGKPKG ++EH+ + L + ++ Sbjct: 3693 IVLEEESLRPEDCGNPAIVNGASDLAYVMYTSGSTGKPKGVMVEHRNVTRLVM-HTNYVQ 3751 Query: 1488 IQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAIL 1547 +++ +R++Q +I FD +I ++L G +L L +K++L D FL +N+IT L Sbjct: 3752 VRESDRMIQTGAIGFDAMTFEIFGALLHGASLYLVSKDVLLDAEKLGDFLRTNQITTMWL 3811 Query: 1548 -PPTY--LANLNPNNIHTVDKMITIGSAISSGLVNEWKRK---CEYINAYGPTETTVYSS 1601 P + L+ NP ++ +I G A+S +N K E N YGPTE T +S+ Sbjct: 3812 TSPLFNQLSQDNPAMFDSLRALIVGGEALSPKHINRVKSALPDLEIWNGYGPTENTTFST 3871 Query: 1602 VWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEM 1661 ++ + E + +PIGKPI N+ YI+D QP+G+PGELC+GG G+ RGY +PE+ Sbjct: 3872 CYLIEQHFE--EQIPIGKPIANSTAYIVDGNNQPQPIGVPGELCVGGDGVARGYVNKPEL 3929 Query: 1662 TADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKI 1721 TA+K + + +YRTGDLARWLPDG +EYLGR+D+QVKIRG+R+E EI+ L + Sbjct: 3930 TAEKFVPNPFAPGETMYRTGDLARWLPDGTIEYLGRIDQQVKIRGYRIELGEIETVLSQQ 3989 Query: 1722 EGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPL 1781 +K+ +V + ++CAY++ ELR+ + +LP +M+PAY+V+ME PL Sbjct: 3990 AQVKEAVVAVIEEANGQKALCAYFVPEQAVDAAELREAMSKQLPGYMVPAYYVQMEKLPL 4049 Query: 1782 TSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGD 1841 T+NGK+D++ LP P S ++ +N+ E L ++W+EVL + +GI DNFFE+GG Sbjct: 4050 TANGKVDRRALPQPSGERTTGSAFVAAQNDTEAKLQQIWQEVLGIPAIGIHDNFFEIGGH 4109 Query: 1842 SLKAMQVAAILGK-HRLHMEIKDLFHRQKIAELSECVRD 1879 SLKAM V + K ++ + +K LF I EL+ + + Sbjct: 4110 SLKAMNVITQVHKTFQVELPLKALFATPTIHELAAHIAE 4148 Score = 1399 bits (3621), Expect = 0.0, Method: Compositional matrix adjust. Identities = 789/2145 (36%), Positives = 1216/2145 (56%), Gaps = 109/2145 (5%) Query: 9 NVLLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQ 67 N L T KK++++WLN + TD P S G L L ++LQ Sbjct: 1220 NELFQTEAYKKQEQHWLNTFADEIPLLNLPTDYPRPSVQSFAGDLVL-FAAGKELLERLQ 1278 Query: 68 HLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPIID 123 +++ + +LY ILL A L+ K+T I V +PV + D + + + + + + Sbjct: 1279 QVASETGTTLYMILLAAYNVLLSKYTGQEDIIVGTPVAGRSHADVENIMGIFVNTLALRN 1338 Query: 124 TFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHN 183 + TF + L +V++ L AYDHQDYPF++++E + D + + L L N + Sbjct: 1339 QPASSKTFAQFLQEVKQNALAAYDHQDYPFEELVEKLAIQRDISRNPLFDTLFSLENANQ 1398 Query: 184 DAV-IPDVGS------------NIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQ 230 ++ I ++ + ++ + A I L + K F + V ++A+ Y + Sbjct: 1399 QSLAIAELTASPYELFNKISKFDLALNASESPADIQFQLTFATKLFKKETVERMARHYLE 1458 Query: 231 ILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTY-QNMEDMTLYELFEKQVRQTPDHVA 289 IL+ +E + L + T+ + L++L E+Q +TPD VA Sbjct: 1459 ILRWISEQPTASLADIDMMTEAEKRTLLLNVNDTFVERTAATALHQLVEEQAARTPDEVA 1518 Query: 290 VKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYL 349 V + ++TYR+LNA+AN+LAR+LR+ G G + ++G++V+RS M G+L +LK+G AY Sbjct: 1519 VVYEEYALTYRELNARANQLARLLRSHGTGPDTLIGIMVDRSPGMVVGMLAVLKAGGAYT 1578 Query: 350 PLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLEN-ESDLDLIL 408 P+D P ER+Q+++ D+ + ++ + +E G +I +D++ + +++LD + Sbjct: 1579 PIDPSYPPERIQYMLSDSQAPILLTQRHLQELAAYQG-EIIDVDEEAIYTGADTNLDNVA 1637 Query: 409 GRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDGF 468 G+ D AYVIYTSG+TG PKGV+I H++I N + W + + D +LQ + FD Sbjct: 1638 GK--DDLAYVIYTSGSTGNPKGVMISHQAICNHMLWMRETFPLTTEDAVLQKTPFSFDAS 1695 Query: 469 LTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEAQ 528 + F+ P+++G +V RD + +LI KIT VP+L ++ + Sbjct: 1696 VWEFYLPLITGGQLVLAKPDGHRDIAYMTRLIRDEKITTLQMVPSLLDLVMTDPGWSACT 1755 Query: 529 SLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDD-TELTIGK 587 SL+ V GE +TP L+ + +++N YGPTE+++ AT + + + + IGK Sbjct: 1756 SLQRVFCGGEALTPALVSRFYETQQA-QLINLYGPTETTIDATYWPCPRQQEYSAIPIGK 1814 Query: 588 PIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERMYR 647 PI N R+Y+V + +L+ G+ GELCI+G GLARGY E LT+ FV NPFE MYR Sbjct: 1815 PIDNVRLYVVNASNQLQPVGVAGELCIAGDGLARGYWQREELTKASFVDNPFEPGGTMYR 1874 Query: 648 TGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNS 707 TGD+ R+ G IE +GR D QVK+RG+RIELGEIE LL++ + VV +D + Sbjct: 1875 TGDMVRYLPDGHIEYLGRIDHQVKIRGHRIELGEIEATLLQHEAVKAVVVMARQDGKGQN 1934 Query: 708 RICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLK 767 + AY+V ++ + ELR LS +LP YM+P+ F LEQ P++ GK+DR AL +D Sbjct: 1935 SLYAYVVAEQDIQTAELRTYLSATLPAYMVPSAFVFLEQLPLSANGKVDRKALPQPEDAA 1994 Query: 768 ELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVE 827 A + P NE E++L IW++VL V+ + +HD+FF LGGHSLKA ++S L + FQV+ Sbjct: 1995 ASAAVYVAPRNEWEAKLAAIWESVLGVEPIGVHDHFFELGGHSLKAMHVISLLQRSFQVD 2054 Query: 828 IELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGESTS 887 + L +FE TI LA L+ + R GTY++I P EK++YYP+S+AQKRM+ L +EG S Sbjct: 2055 VPLKVLFESPTIAGLAPLVAAARKGTYTAIPPVEKQEYYPVSAAQKRMFILQQMEGAGIS 2114 Query: 888 YNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYTEE 947 YNMP M ++G+LD +++ L+ ++ RHE LRTSFH + E VQ VHD +D +I + E Sbjct: 2115 YNMPGFMYLDGKLDTERLQQALKSLVQRHESLRTSFHSVQGETVQRVHDDVDLAISFGEA 2174 Query: 948 KIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELA 1007 + R A++FIQPFDL T+PL R +IK+A +LFM D+HHI+ DG+SIGL I+E A Sbjct: 2175 TEAETRQIAEQFIQPFDLGTAPLLRAGLIKLAPERHLFMLDLHHIVVDGVSIGLLIEEFA 2234 Query: 1008 LLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVH 1067 LY LP IQ+KDF+ W+++ + +F +QE +WL F GE+P+L LP DY RP Sbjct: 2235 QLYHGEELPALRIQYKDFAKWQQDWFQTEEFAEQEAYWLNTFTGEIPVLNLPTDYPRPSV 2294 Query: 1068 KSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTR 1127 KS+ G + F ++L +LA + G TLYM+LLA +N++LSK + QEDIIVG+P Sbjct: 2295 KSFAGDRFVFGSGTALPKQLHQLAQETGTTLYMVLLAAYNVLLSKYSRQEDIIVGAPTAG 2354 Query: 1128 RRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDI 1187 R E ES++GMF NTLA+RN PAG K F+DFL EVK + L AF++QDY +E++ KLD+ Sbjct: 2355 RSHAETESIVGMFVNTLALRNEPAGGKTFRDFLAEVKINTLGAFEHQDYPLDELVDKLDM 2414 Query: 1188 VRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCS 1247 RD RNPLFD + ILQN+ F+ ++ ++ Y E ++FD++L E + + S Sbjct: 2415 QRDLSRNPLFDTVFILQNMEQKPFEMEQLTITPYSAEVKQAKFDLSLEAYEE-NAEIIFS 2473 Query: 1248 FEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILA-FNQTSFDL 1306 +Y T+LF RET+E + + I+ VIA+ E+ +S+I M++E Q++L FN D Sbjct: 2474 LDYSTKLFSRETIEKIATHFIQILRAVIAEPEMPLSEITMLTEAEKQRLLVDFNGAHKDF 2533 Query: 1307 PADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLM 1366 P ++T+ LFEEQA++ A+E Q +SY ELN+RANQLA LRE+GV VG+M Sbjct: 2534 PQNKTLQALFEEQAEKSPQATAVEISGQPLSYQELNERANQLAATLRERGVQPDQPVGIM 2593 Query: 1367 FERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGE 1426 RS EM++G L ILK+GGAY+PIDP+YP ER+ +M+ D +LVLTQ L G Sbjct: 2594 ANRSVEMVVGILAILKAGGAYVPIDPEYPEERVAYMLTDCQARLVLTQKHLGAKL---GS 2650 Query: 1427 VIDLNCAGLNN-----MDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTAS 1481 + C L++ + SNL IN +SDLAY+IYTSGTTGKPKG ++EH+GIVN Sbjct: 2651 SVTAECLYLDDESNYGVHRSNLQPINTASDLAYIIYTSGTTGKPKGVMVEHRGIVNNVLW 2710 Query: 1482 NKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNR 1541 K + +++ +R + S +FD ++ +L G T+ L E D + + ++R Sbjct: 2711 KKAEYQMKVGDRSLLSLSFAFDAFVLSFFTPVLSGATVVLAEDEEAKDPVSLKKLIAASR 2770 Query: 1542 ITAAILPPTYLANL----NPNNIHTVDKMITIGSAISSGLVNEWKR---KCEYINAYGPT 1594 T P+ + P +I + + G I++ LV + K+ +N YGPT Sbjct: 2771 CTLMTGVPSLFQAILECSTPADIRPLQTVTLGGEKITAQLVEKCKQLNPDLVIVNEYGPT 2830 Query: 1595 ETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRG 1654 E++V ++ W + D + IG+PI NT +YI+++Y LQP+G+ GE+CIGG GL RG Sbjct: 2831 ESSVVAT-W--QRLAGPDAAITIGRPIANTSLYIVNQYHQLQPIGVVGEICIGGRGLARG 2887 Query: 1655 YWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEI 1714 YW +P +T +K ++ + ++Y+TGDL +WLPDG +EY+GR+DEQVK+RG+R+E EI Sbjct: 2888 YWNKPALTEEKFVSHPFAAGERMYKTGDLGKWLPDGTIEYIGRIDEQVKVRGYRIEIGEI 2947 Query: 1715 KAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFV 1774 ++ LL E + +V ++QL +++ AY+ + VT+L L +LP +MIPA+FV Sbjct: 2948 ESALLAAEKLTAAVVVVYEDQLGQSALAAYFTADEQLDVTKLWSHLSKRLPSYMIPAHFV 3007 Query: 1775 RMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDN 1834 +++ PLT NGK+D+K LP PE + Y+ P N +E LAE+WE VL + +GI DN Sbjct: 3008 QLDQLPLTPNGKVDKKALPKPEGKPVTEAQYVAPTNAVESKLAEIWERVLGVSGIGILDN 3067 Query: 1835 FFEVGGDSLKAMQVAA-ILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRI 1893 FF++GG SLKAM VAA + ++++ + +K LF + I L++ V Sbjct: 3068 FFQIGGHSLKAMAVAAQVHREYQVELPLKVLFAQPTIKALAQYVA--------------- 3112 Query: 1894 DSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHT 1953 +SG E IE QE S + V + Y++ +A + Sbjct: 3113 -TSGKETYVPIE--------PAPLQEYYPVSSAQKRMYVLRQFADTGTVYNMPSALYIEG 3163 Query: 1954 SIPFRSCGDIGKIQKAILRLVNEQVLLRSVI--VNDGENTYFYEHGSVYNLPFILIDLSG 2011 + D + + AI LV LR+ VN +EH + N+ + + + Sbjct: 3164 DL------DRKRFEAAIHGLVERHESLRTSFHTVNGEPVQRVHEHVEL-NVQYAEVTEAQ 3216 Query: 2012 FDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGI 2071 + S A+ K P L R+ L + A + ++ L H +SDG+S GI Sbjct: 3217 VEPTVESFVQAF---DLTKAP-------LLRVGLFKLAAKRHLFLLDMHHIISDGVSAGI 3266 Query: 2072 ITDQLAAYFAGDSSLPVHSLKH------------------HQNYW 2098 I ++ + + G+ LP S+ + H+NYW Sbjct: 3267 IMEEFSKLYRGE-ELPALSVHYKDFAVWQSELFQSDVYTEHENYW 3310 Score = 1347 bits (3485), Expect = 0.0, Method: Compositional matrix adjust. Identities = 761/2118 (35%), Positives = 1195/2118 (56%), Gaps = 102/2118 (4%) Query: 11 LLSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSAL----GIEGKESLRLDIPDGLFQQL 66 L + + + YWLN G D +L P + EG + + L L Sbjct: 3297 LFQSDVYTEHENYWLNAFSG---DIPVLNLPADFSRPLTQSFEG-DCVSFQADKALLDDL 3352 Query: 67 QHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPII 122 L+ S +L+ +LL A L+ K++ I V +P+ + D + + + + + Sbjct: 3353 HKLAQESQSTLFMVLLAAYNVLLAKYSGQEDIVVGTPIAGRSHADIENVLGMFVNTLALR 3412 Query: 123 DTFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIH 182 + F+ L +V++ TL AY HQDYPF+ ++E + D + + + +L N+ Sbjct: 3413 NYPVETKHFQAFLEEVKQNTLQAYAHQDYPFEALVEKLDIQRDLSRNPLFDTMFILQNLD 3472 Query: 183 NDA---------VIPDVGSNIVFGFT----RDDAGISLNLIYNLKYFTRNFVMQLAKQYF 229 A P N F T D+ GI L+Y+ K F R + ++A + Sbjct: 3473 QKAYELDGLKLEAYPAQAGNAKFDLTLEAHEDETGIHFALVYSTKLFQRESIERMAGHFL 3532 Query: 230 QILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNM-EDMTLYELFEKQVRQTPDHV 288 Q+L+ + + L + T+ D+T+ ELFE+Q +TP+H Sbjct: 3533 QVLRQVVADQATALREISLLSEEERRIVTVDFNNTFAAYPRDLTIQELFEQQAAKTPEHA 3592 Query: 289 AVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAY 348 AV + Q +TYR+LN KAN+LA VLR GVG IVGLL +RS++M GI+GILK+G AY Sbjct: 3593 AVVMDGQMLTYRELNEKANQLAHVLRQNGVGKESIVGLLADRSLEMITGIMGILKAGGAY 3652 Query: 349 LPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDLIL 408 L LD + P ERL +++ED G++V + K L +GL I L+++ L + I+ Sbjct: 3653 LGLDPEHPSERLAYMLEDGGVKVVLVQKHLL-PLVGEGLMPIVLEEESLRPEDCGNPAIV 3711 Query: 409 GRALDHPAYVIYTSGTTGQPKGVIIEHRSIS------NTIQWRKSEYSFDASDRMLQLFS 462 A D AYV+YTSG+TG+PKGV++EHR+++ N +Q R+S DRM+Q + Sbjct: 3712 NGASDL-AYVMYTSGSTGKPKGVMVEHRNVTRLVMHTNYVQVRES-------DRMIQTGA 3763 Query: 463 YIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNM 522 FD F ++ GA++ + + D + + ++IT L++ L ++ Sbjct: 3764 IGFDAMTFEIFGALLHGASLYLVSKDVLLDAEKLGDFLRTNQITTMWLTSPLFNQLSQD- 3822 Query: 523 KPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTE 582 P SLR + + GE ++P + K P +EI N YGPTE++ +T + + + Sbjct: 3823 NPAMFDSLRALIVGGEALSPKHINRVKSALPDLEIWNGYGPTENTTFSTCYLIEQHFEEQ 3882 Query: 583 LTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEAN 642 + IGKPI N+ YIV N + + G+ GELC+ G G+ARGY++ LT +KFV NPF Sbjct: 3883 IPIGKPIANSTAYIVDGNNQPQPIGVPGELCVGGDGVARGYVNKPELTAEKFVPNPFAPG 3942 Query: 643 ERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWED 702 E MYRTGDLARW G IE +GR D QVK+RGYRIELGEIE L + + EAVVA+ E+ Sbjct: 3943 ETMYRTGDLARWLPDGTIEYLGRIDQQVKIRGYRIELGEIETVLSQQAQVKEAVVAVIEE 4002 Query: 703 QNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRN 762 N +CAY V ++ + A ELRE++SK LP YM+P ++ Q+E+ P+T GK+DR AL Sbjct: 4003 ANGQKALCAYFVPEQAVDAAELREAMSKQLPGYMVPAYYVQMEKLPLTANGKVDRRALPQ 4062 Query: 763 NQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHK 822 + G+ F N+ E++L +IW+ VL + + IHDNFF +GGHSLKA +++++HK Sbjct: 4063 PSGERTTGSAFVAAQNDTEAKLQQIWQEVLGIPAIGIHDNFFEIGGHSLKAMNVITQVHK 4122 Query: 823 EFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLE 882 FQVE+ L +F TI LAA I + +I P E +YP+S AQKRMY L+ E Sbjct: 4123 TFQVELPLKALFATPTIHELAAHIAESAFEQFETIQPVEPAAFYPVSFAQKRMYILHQFE 4182 Query: 883 GESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSI 942 G SYN+P V+V+EG+LD + + ++ ++ RHE LRTSFH ++ EP+Q VH ++ + Sbjct: 4183 GSGISYNVPSVLVLEGKLDYDRFAAAIQSLVKRHESLRTSFHSVNGEPLQRVHPDVELPV 4242 Query: 943 DYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLF 1002 E D IQPFDL+ +PLFRV +IK+ + +LF DMHHIISDG+S+ + Sbjct: 4243 RLLEATEDQSESLIQELIQPFDLEIAPLFRVNLIKLGAERHLFFMDMHHIISDGVSLAVI 4302 Query: 1003 IKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDY 1062 ++E+A LY L + IQ+KDF+VW+ + A++ F++QE+FW + F GE+PLL LP DY Sbjct: 4303 VEEIASLYAGKQLSDLRIQYKDFAVWQTKLAQSDRFQKQEDFWTRTFAGEIPLLNLPHDY 4362 Query: 1063 KRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVG 1122 RP +S++G + +L++LA + G TL+M+LLA ++++LSK QE+I+VG Sbjct: 4363 PRPSVQSFDGDTVALGTGHHLLEQLRKLAAETGTTLFMVLLAAYHVLLSKYAGQEEIVVG 4422 Query: 1123 SPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMI 1182 +P+ R ++E ++GMF NTLA++N AG+ F+ FL +VK +AL AF++QDY FE ++ Sbjct: 4423 TPIAGRSHADVERIVGMFVNTLALKNTAAGSLSFRAFLEDVKQNALHAFEHQDYPFEHLV 4482 Query: 1183 SKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDG 1242 KL + RD RNPLFD M L + + ++KVS Y +I++FD++L +E DG Sbjct: 4483 EKLQVRRDLSRNPLFDTMFSLGLAESAEGEVADLKVSPYPVNGHIAKFDLSLDAMEKQDG 4542 Query: 1243 LLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQ 1301 LL F YCT+LF +ETV+ + + ++ + AD +I ++ I ++S+ + +L +F Sbjct: 4543 LL-VQFSYCTKLFAKETVDRLAAHYVQLLQTITADPDIELARISVLSKAETEHMLHSFLA 4601 Query: 1302 TSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGS 1361 T P D+T LFEEQ ++ +E A+ F ++ ++Y ELN +ANQLAR+LR KGV S Sbjct: 4602 TKTAYPTDKTFQKLFEEQVEKTPNEIAVLFGNEQLTYQELNAKANQLARVLRRKGVKPES 4661 Query: 1362 VVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWL 1421 VG++ +RS M+IG L +LK+GG ++PIDPDYP ER FM+EDS +L+LT + + Sbjct: 4662 TVGILVDRSLYMVIGMLAVLKAGGTFVPIDPDYPLERQAFMLEDSEAKLLLTLQKMNSQV 4721 Query: 1422 DFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTAS 1481 F E L+ ++ + NL + + ++AY+IYTSGTTGKPKG ++EH+ N+ + Sbjct: 4722 AFPYETFYLDTETVDQEETGNLEHVAQPENVAYIIYTSGTTGKPKGVVIEHRSYANVAFA 4781 Query: 1482 NKEQLKIQDRE-RVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSN 1540 K++ + R++Q +S +FDVS D + ++L GG L + + D + + + Sbjct: 4782 WKDEYHLDSFPVRLLQMASFAFDVSTGDFARALLTGGQLVICPNGVKMDPASLYETIRRH 4841 Query: 1541 RIT------AAILPPTYLANLNPNNIHTVDKMITIGSAISSG-----LVNEWKRKCEYIN 1589 IT A I+P + N ++ + K++ +G+ L+ + +K IN Sbjct: 4842 EITIFEATPALIMPLMHYVYENELDMSQM-KLLILGADSCPAEDFKTLLARFGQKMRIIN 4900 Query: 1590 AYGPTETTVYSSVWIANKQGEV-DDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGG 1648 +YG TE + +S + + VPIGKP+ N MY++D + NLQPVG+ GELCIGG Sbjct: 4901 SYGVTEACIDTSYYEETDVTAIRSGTVPIGKPLPNMTMYVVDAHLNLQPVGVVGELCIGG 4960 Query: 1649 IGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFR 1708 G+ RGY RPE+T +K + + ++YRTGDLA+W DGN+E+LGR D QVKIRG R Sbjct: 4961 AGVARGYLNRPELTEEKFVPNPFAPGERLYRTGDLAKWRADGNVEFLGRNDHQVKIRGVR 5020 Query: 1709 VEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFM 1768 +E EI+ +L K++GI + +V R+++ Q +CAY ++ ELR LL +LP+ M Sbjct: 5021 IELGEIETQLRKLDGITEAVVVAREDRGQEKELCAYVVADHKLDTAELRANLLKELPQAM 5080 Query: 1769 IPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEK 1828 IPAYFV ++A PLT+NGK+D++ LP P+ +M R + Y+ PR+ E LA+VWE+VL + + Sbjct: 5081 IPAYFVTLDALPLTANGKVDRRSLPAPDVTMLRTTEYVAPRSVWEARLAQVWEQVLNVPQ 5140 Query: 1829 VGIEDNFFEVGGDSLKAMQV-AAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVE 1887 VG D+FF +GG SL+AM+V +++ ++++ + ++ LF + I EL+ + + + Sbjct: 5141 VGALDDFFALGGHSLRAMRVLSSMHNEYQVDIPLRILFEKPTIQELAAFIEETAKGNVF- 5199 Query: 1888 NPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMN 1947 SIE ++ Q S + + Y++ + Sbjct: 5200 ---------------SIE--------PVQKQAYYPVSSAQKRMYILDQFEGVGISYNMPS 5236 Query: 1948 AEKVHTSIPFRSCGDIGKIQKAILRLVNEQVLLRS--VIVNDGENTYFYEHGSVYNLPFI 2005 + + + +++ A RL+ LR+ +VN +E ++PF Sbjct: 5237 TMLIEGKL------ERTRVEAAFQRLIARHESLRTSFAVVNGEPVQNIHE-----DVPFA 5285 Query: 2006 LIDLSGFDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSD 2065 L + R + +Q PF+ + L R+ L++ + Y+L H++SD Sbjct: 5286 LAYSEVTEQEARELVSSLVQ------PFDLEVAPLIRVSLLKIGEDRYVLFTDMHHSISD 5339 Query: 2066 GLSLGIITDQLAAYFAGD 2083 G+S GI+ + + GD Sbjct: 5340 GVSSGILLAEWVQLYQGD 5357 Score = 1303 bits (3373), Expect = 0.0, Method: Compositional matrix adjust. Identities = 730/1921 (38%), Positives = 1104/1921 (57%), Gaps = 65/1921 (3%) Query: 11 LLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQHL 69 L + +K++ +W G + D P S +G +++ L L +QL+ L Sbjct: 4332 LAQSDRFQKQEDFWTRTFAGEIPLLNLPHDYPRPSVQSFDG-DTVALGTGHHLLEQLRKL 4390 Query: 70 SNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPIIDTF 125 + + +L+ +LL A L+ K+ I V +P+ + D + + + + +T Sbjct: 4391 AAETGTTLFMVLLAAYHVLLSKYAGQEEIVVGTPIAGRSHADVERIVGMFVNTLALKNTA 4450 Query: 126 TTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISD--RDFSF-VRHVLCLLTNIH 182 ++FR L V++ L A++HQDYPF+ ++E +Q D R+ F L L + Sbjct: 4451 AGSLSFRAFLEDVKQNALHAFEHQDYPFEHLVEKLQVRRDLSRNPLFDTMFSLGLAESAE 4510 Query: 183 NDAV------IPDVGSNIVFGFTRD----DAGISLNLIYNLKYFTRNFVMQLAKQYFQIL 232 + P G F + D G+ + Y K F + V +LA Y Q+L Sbjct: 4511 GEVADLKVSPYPVNGHIAKFDLSLDAMEKQDGLLVQFSYCTKLFAKETVDRLAAHYVQLL 4570 Query: 233 KGAAENVSIKLG--SMXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQVRQTPDHVAV 290 + + I+L S+ T+T D T +LFE+QV +TP+ +AV Sbjct: 4571 QTITADPDIELARISVLSKAETEHMLHSFLATKTAYPT-DKTFQKLFEEQVEKTPNEIAV 4629 Query: 291 KFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLP 350 F N+ +TY++LNAKAN+LARVLR +GV VG+LV+RS+ M G+L +LK+G ++P Sbjct: 4630 LFGNEQLTYQELNAKANQLARVLRRKGVKPESTVGILVDRSLYMVIGMLAVLKAGGTFVP 4689 Query: 351 LDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDLILGR 410 +D P ER F++ED+ ++ ++ ++ ++ T + V E +L+ + Sbjct: 4690 IDPDYPLERQAFMLEDSEAKLLLTLQKMNSQVAFPYETFYLDTETVDQEETGNLEHVAQP 4749 Query: 411 ALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASD-RMLQLFSYIFDGFL 469 ++ AY+IYTSGTTG+PKGV+IEHRS +N K EY D+ R+LQ+ S+ FD Sbjct: 4750 --ENVAYIIYTSGTTGKPKGVVIEHRSYANVAFAWKDEYHLDSFPVRLLQMASFAFDVST 4807 Query: 470 TSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEE--A 527 F +++G +V DP ++ + I H+IT F A P L L+ + E Sbjct: 4808 GDFARALLTGGQLVICPNGVKMDPASLYETIRRHEITIFEATPALIMPLMHYVYENELDM 4867 Query: 528 QSLRIVTLAGEKVTP---NLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELT 584 ++++ L + L+A + M I+N YG TE+ + + ++T++T Sbjct: 4868 SQMKLLILGADSCPAEDFKTLLA--RFGQKMRIINSYGVTEACIDTSYY-----EETDVT 4920 Query: 585 --------IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVS 636 IGKP+ N +Y+V +L L+ G+VGELCI GAG+ARGYL+ LT +KFV Sbjct: 4921 AIRSGTVPIGKPLPNMTMYVVDAHLNLQPVGVVGELCIGGAGVARGYLNRPELTEEKFVP 4980 Query: 637 NPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAV 696 NPF ER+YRTGDLA+W G +E +GR D QVK+RG RIELGEIE +L + +GITEAV Sbjct: 4981 NPFAPGERLYRTGDLAKWRADGNVEFLGRNDHQVKIRGVRIELGEIETQLRKLDGITEAV 5040 Query: 697 VALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMD 756 V ED+ +CAY+V D L ELR +L K LP+ M+P +F L+ P+T GK+D Sbjct: 5041 VVAREDRGQEKELCAYVVADHKLDTAELRANLLKELPQAMIPAYFVTLDALPLTANGKVD 5100 Query: 757 RNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATML 816 R +L + P + E+RL ++W+ VL V +V D+FF LGGHSL+A + Sbjct: 5101 RRSLPAPDVTMLRTTEYVAPRSVWEARLAQVWEQVLNVPQVGALDDFFALGGHSLRAMRV 5160 Query: 817 LSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMY 876 LS +H E+QV+I L +FEK TI LAA I+ G SI P +K+ YYP+SSAQKRMY Sbjct: 5161 LSSMHNEYQVDIPLRILFEKPTIQELAAFIEETAKGNVFSIEPVQKQAYYPVSSAQKRMY 5220 Query: 877 ALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHD 936 L EG SYNMP M++EG+L+ +VE+ +++I+RHE LRTSF +++ EPVQ +H+ Sbjct: 5221 ILDQFEGVGISYNMPSTMLIEGKLERTRVEAAFQRLIARHESLRTSFAVVNGEPVQNIHE 5280 Query: 937 TIDFSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDG 996 + F++ Y+E + R +QPFDL+ +PL RV ++KI Y+ DMHH ISDG Sbjct: 5281 DVPFALAYSEVTEQEARELVSSLVQPFDLEVAPLIRVSLLKIGEDRYVLFTDMHHSISDG 5340 Query: 997 ISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLL 1056 +S G+ + E LY VLPE IQ+KDF+VW++E +++ F +QE +WL+ F ++P+L Sbjct: 5341 VSSGILLAEWVQLYQGDVLPELRIQYKDFAVWQQEFSQSAAFHKQEAYWLQTFADDIPVL 5400 Query: 1057 ELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQ 1116 LP D+ RP +S+ G + K T L +LA G TLYM+LLA +N++L+K Q Sbjct: 5401 NLPTDFTRPSTQSFAGDQCTIGAGKALTEGLHQLAQATGTTLYMVLLAAYNVLLAKYAGQ 5460 Query: 1117 EDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDY 1176 EDIIVG+P+T R +LE ++GMF NTLAMRN P K F +FL EVK +AL A+ +QDY Sbjct: 5461 EDIIVGTPITGRSHADLEPIVGMFVNTLAMRNKPQREKTFSEFLQEVKQNALDAYGHQDY 5520 Query: 1177 QFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFY--EHEHNISRFDITL 1234 FEE++ KL I RD RNPLFD + QN E ++ + + ++FD+T Sbjct: 5521 PFEELVEKLAIARDLSRNPLFDTVFTFQNSTEEVMTLPECTLAPFMTDETGQHAKFDLTF 5580 Query: 1235 HCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQ 1294 E + + EY T LF RET+E + I ++ + IR+ +I M+ Q Sbjct: 5581 SATEEREEMT-IGVEYSTSLFTRETMERFSRHFLTIAASIVQNPHIRLGEIDMLLPEEKQ 5639 Query: 1295 QILA-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLR 1353 QILA FN T+ D+T+H LFEEQ + D+ AL F +Q+++Y ELN+RAN+LAR+LR Sbjct: 5640 QILAGFNDTAVSYALDKTLHQLFEEQVDKTPDQAALLFSEQSLTYSELNERANRLARVLR 5699 Query: 1354 EKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLT 1413 KGV +V +M ERS EM+IG LGILK+GGAY+P+DP YP ERI++++EDS L+L+ Sbjct: 5700 AKGVGPDRLVAIMAERSPEMVIGILGILKAGGAYVPVDPGYPQERIQYLLEDSNAALLLS 5759 Query: 1414 QNIPYNWLDFDG----EVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTL 1469 Q L E +DLN + GSNLP +N+ +DLAY+IYTSGTTGKPKG + Sbjct: 5760 QAHLLPLLAQVSSELPECLDLNAELDAGLSGSNLPAVNQPTDLAYVIYTSGTTGKPKGVM 5819 Query: 1470 LEHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILND 1529 + H+GIVN +++ ++ +Q S +FD + + +L G T L + D Sbjct: 5820 IPHQGIVNCLQWRRDEYGFGPSDKALQVFSFAFDGFVASLFAPLLGGATCVLPQEAAAKD 5879 Query: 1530 NSCFEAFLNSNRITAAI-LPPTYLANLNPNNIHTVDKMITI---GSAISSGLVNEWKRKC 1585 + + + +T +P + A L+ + +++ + G + LV + K K Sbjct: 5880 PVALKKLMAATEVTHYYGVPSLFQAILDCSTTTDFNQLRCVTLGGEKLPVQLVQKTKEKH 5939 Query: 1586 EYI---NAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPG 1642 I N YGPTE +V +++ ++ E + IG+P+ N Q+YI+D+ +LQP+G+ G Sbjct: 5940 PAIEINNEYGPTENSVVTTI---SRSIEAGQAITIGRPLANVQVYIVDEQHHLQPIGVVG 5996 Query: 1643 ELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQV 1702 ELCIGG GL RGY +PE+TA+K + ++Y+TGDL +W DG +EY+GR DEQV Sbjct: 5997 ELCIGGAGLARGYLNKPELTAEKFVANPFRPGERMYKTGDLVKWRTDGTIEYIGRADEQV 6056 Query: 1703 KIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHAS-ICAYYISAMDYSVTELRKQLL 1761 K+RG+R+E EI++ +L +GI +V R + S +CAY+++A SV+ LR L Sbjct: 6057 KVRGYRIEIGEIESAVLAYQGIDQAVVVARDDDATAGSYLCAYFVAATAVSVSGLRSHLA 6116 Query: 1762 SKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWE 1821 +LP +MIP+YFV ++ PL++NGK+D+K LP P+ S Y+ PRN E LA +W+ Sbjct: 6117 KELPAYMIPSYFVELDQLPLSANGKVDRKALPKPQQSDATTREYVAPRNATEQQLAAIWQ 6176 Query: 1822 EVLRLEKVGIEDNFFEVGGDSLKA-MQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDL 1880 EVL +E +GI D FFE+GG SLKA + +A + ++ + + +F I ++++ + Sbjct: 6177 EVLGVEPIGITDQFFELGGHSLKATLLIAKVYEYMQIELPLNLIFQYPTIEKVADFITHK 6236 Query: 1881 R 1881 R Sbjct: 6237 R 6237 Score = 1212 bits (3137), Expect = 0.0, Method: Compositional matrix adjust. Identities = 684/1858 (36%), Positives = 1064/1858 (57%), Gaps = 85/1858 (4%) Query: 270 DMTLYELFEKQVRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVE 329 D T++EL +Q +TP AV ++TY++L ++ +LA LR +G+ + IV ++ E Sbjct: 463 DKTIFELIAEQASRTPAKAAVVCGEDTLTYQELMERSAQLANALREKGIASGSIVSIMAE 522 Query: 330 RSIDMAGGILGILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTV 389 S+++ I+ +L+SGAAYLP+D + P++R+Q+L++D+ + ++ + ++ G +V Sbjct: 523 HSLELIVAIMAVLRSGAAYLPIDPEYPQDRIQYLLDDSQTTLLLTQSHLQPNIRFAG-SV 581 Query: 390 IRLDDDVLLENESDLDLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEY 449 + LDD L E S D AY+IYTSG+TG PKG +I H+ + N I W Y Sbjct: 582 LYLDDRSLYEGGST-SFAPESKPDDLAYMIYTSGSTGNPKGAMITHQGLVNYIWWANKVY 640 Query: 450 -SFDASDRMLQLFSYI-FDGFLTSFFTPIVSGATV-VFLDETEARDPLAIIQLITLHKIT 506 +A D L+S I FD +TS FTP++SG T+ V+ + + I+ +I +K+ Sbjct: 641 VQGEAVD--FPLYSSISFDLTVTSIFTPLLSGNTIHVYRGADKVQ---VILDIIKDNKVG 695 Query: 507 HFIAVPTLYSALLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLH----PGMEIVNEYG 562 PT + L+ ++ +A S+R + GE + L +KQ++ ++I NEYG Sbjct: 696 IIKLTPT-HLKLIEHID-GKASSIRRFIVGGENLPTKL---AKQIYDHFGENVQIFNEYG 750 Query: 563 PTESSVLATLKRDLKPDDT---ELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGL 619 PTE+ V+ + P T + IG P N ++Y++ +++ G +GE+ I+G G+ Sbjct: 751 PTET-VVGCMIYLYDPQTTTQESVPIGVPADNVQLYLLDASMQPVPVGSLGEMYIAGDGV 809 Query: 620 ARGYLHNEVLTRDKFVSNPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIEL 679 A+GY + LT++KF+ NPF +MYRTGDLA+W G +E GR D QVK+RG+RIE+ Sbjct: 810 AKGYFNRPELTKEKFIDNPFRPGTKMYRTGDLAKWLPDGNMEYAGRMDYQVKIRGHRIEM 869 Query: 680 GEIENRLLEYNGITEAVVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPT 739 GEIE RL ++ + EAVV + +D++ + + AY+V +R L+ ELRE L ++LP YM+P+ Sbjct: 870 GEIETRLTQHEAVKEAVVIVEKDESGQNVLYAYLVSERELTVAELREFLGRTLPSYMIPS 929 Query: 740 HFFQLEQFPMTPTGKMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSI 799 F +L + P+T GK++R L G + P NEIE++L EIW+ VL + +V I Sbjct: 930 FFIRLAEIPLTANGKVERKKLPKPAGAVVTGTAYAAPQNEIEAKLAEIWQQVLGISQVGI 989 Query: 800 HDNFFMLGGHSLKATMLLSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILP 859 HD+FF LGGHSLKA ++ ++ K +VE+ + +FE T+ LA + Y++I P Sbjct: 990 HDDFFDLGGHSLKAMTVVFQVSKALEVELPVKALFEHPTVAELARFLSRSEKTEYTAIQP 1049 Query: 860 TEKRDYYPMSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEIL 919 +++YP+SSAQKRMY L EG SYN+ +++EG+LD + S ++Q+ RHE L Sbjct: 1050 VAAQEFYPVSSAQKRMYILQQFEGNGISYNISGAILLEGKLDYARFASAVQQLAERHEAL 1109 Query: 920 RTSFHMIHHEPVQVVHDTID---FSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKII 976 RTSFH I EPVQ VH+ ++ F ++ E++ + I E F++PFDL +PL R ++ Sbjct: 1110 RTSFHRIDGEPVQKVHEEVEVPLFMLEAPEDQAEKIMRE---FVRPFDLGVAPLMRTGLL 1166 Query: 977 KIASRHYLFMFDMHHIISDGISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENG 1036 K+ +LF+ DMHHIISDG+S + ++E A LY A L +Q+KDF+ W+ E + Sbjct: 1167 KLGKDRHLFLLDMHHIISDGVSSQILLREFAELYQGADLQPLSLQYKDFAAWQNELFQTE 1226 Query: 1037 DFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGA 1096 +K+QE+ WL F E+PLL LP DY RP +S+ G + F KE +L+++A + G Sbjct: 1227 AYKKQEQHWLNTFADEIPLLNLPTDYPRPSVQSFAGDLVLFAAGKELLERLQQVASETGT 1286 Query: 1097 TLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRF 1156 TLYM+LLA +N++LSK T QEDIIVG+PV R ++E++MG+F NTLA+RN PA +K F Sbjct: 1287 TLYMILLAAYNVLLSKYTGQEDIIVGTPVAGRSHADVENIMGIFVNTLALRNQPASSKTF 1346 Query: 1157 KDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEM 1216 FL EVK +AL+A+D+QDY FEE++ KL I RD RNPLFD + L+N E+ Sbjct: 1347 AQFLQEVKQNALAAYDHQDYPFEELVEKLAIQRDISRNPLFDTLFSLENANQQSLAIAEL 1406 Query: 1217 KVSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIA 1276 S YE + IS+FD+ L+ E + + T+LFK+ETVE M + I+ + Sbjct: 1407 TASPYELFNKISKFDLALNASES-PADIQFQLTFATKLFKKETVERMARHYLEILRWISE 1465 Query: 1277 DREIRISDICMVSENAVQQILA-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQT 1335 ++DI M++E + +L N T + A +H L EEQA R DE A+ + + Sbjct: 1466 QPTASLADIDMMTEAEKRTLLLNVNDTFVERTAATALHQLVEEQAARTPDEVAVVYEEYA 1525 Query: 1336 MSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYP 1395 ++Y ELN RANQLARLLR G +++G+M +RS M++G L +LK+GGAY PIDP YP Sbjct: 1526 LTYRELNARANQLARLLRSHGTGPDTLIGIMVDRSPGMVVGMLAVLKAGGAYTPIDPSYP 1585 Query: 1396 GERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYM 1455 ERI++M+ DS ++LTQ + GE+ID++ + +NL + DLAY+ Sbjct: 1586 PERIQYMLSDSQAPILLTQRHLQELAAYQGEIIDVDEEAIYTGADTNLDNVAGKDDLAYV 1645 Query: 1456 IYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILL 1515 IYTSG+TG PKG ++ H+ I N +E + + V+Q + SFD S+ + + ++ Sbjct: 1646 IYTSGSTGNPKGVMISHQAICNHMLWMRETFPLTTEDAVLQKTPFSFDASVWEFYLPLIT 1705 Query: 1516 GGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTY--LANLNP--NNIHTVDKMITIGS 1571 GG L L + D + + +IT + P+ L +P + ++ ++ G Sbjct: 1706 GGQLVLAKPDGHRDIAYMTRLIRDEKITTLQMVPSLLDLVMTDPGWSACTSLQRVFCGGE 1765 Query: 1572 AISSGLVNEW--KRKCEYINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYIL 1629 A++ LV+ + ++ + IN YGPTETT+ ++ W +Q E +PIGKPI N ++Y++ Sbjct: 1766 ALTPALVSRFYETQQAQLINLYGPTETTIDATYWPCPRQQEY-SAIPIGKPIDNVRLYVV 1824 Query: 1630 DKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPD 1689 + LQPVG+ GELCI G GL RGYW+R E+T + G +YRTGD+ R+LPD Sbjct: 1825 NASNQLQPVGVAGELCIAGDGLARGYWQREELTKASFVDNPFEPGGTMYRTGDMVRYLPD 1884 Query: 1690 GNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAM 1749 G++EYLGR+D QVKIRG R+E EI+A LL+ E +K V+V R++ S+ AY ++ Sbjct: 1885 GHIEYLGRIDHQVKIRGHRIELGEIEATLLQHEAVKAVVVMARQDGKGQNSLYAYVVAEQ 1944 Query: 1750 DYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPR 1809 D ELR L + LP +M+P+ FV +E PL++NGK+D+K LP PE++ + Y+ PR Sbjct: 1945 DIQTAELRTYLSATLPAYMVPSAFVFLEQLPLSANGKVDRKALPQPEDAAASAAVYVAPR 2004 Query: 1810 NEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGKH-RLHMEIKDLFHRQ 1868 NE E LA +WE VL +E +G+ D+FFE+GG SLKAM V ++L + ++ + +K LF Sbjct: 2005 NEWEAKLAAIWESVLGVEPIGVHDHFFELGGHSLKAMHVISLLQRSFQVDVPLKVLFESP 2064 Query: 1869 KIAELSECVRDLRNNPIVENPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRN 1928 IA L+ V R P ++ QE + + Sbjct: 2065 TIAGLAPLVAAARKGTYTAIP------------------------PVEKQEYYPVSAAQK 2100 Query: 1929 APLVGKHLPAAVQKYHLMNAEKVHTSIPFRSCGDIGKIQKAILRLVNEQVLLRSVIVNDG 1988 + + + A Y++ + + D ++Q+A+ LV LR+ + Sbjct: 2101 RMFILQQMEGAGISYNMPGFMYLDGKL------DTERLQQALKSLVQRHESLRTSFHSVQ 2154 Query: 1989 ENTYFYEHGSVYNLPFILIDLS-GFDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQ 2047 T H V DL+ F A +E + PF+ L R L++ Sbjct: 2155 GETVQRVHDDV--------DLAISFGEATEAETRQIAEQFIQ--PFDLGTAPLLRAGLIK 2204 Query: 2048 TAPEDYMLLYSADHAVSDGLSLGIITDQLAAYFAGDSSLPVHSLKHHQNYWDYADQMQ 2105 APE ++ + H V DG+S+G++ ++ A + G+ LP ++ Y D+A Q Sbjct: 2205 LAPERHLFMLDLHHIVVDGVSIGLLIEEFAQLYHGE-ELPALRIQ----YKDFAKWQQ 2257 Score = 520 bits (1340), Expect = e-145, Method: Compositional matrix adjust. Identities = 333/1041 (31%), Positives = 556/1041 (53%), Gaps = 50/1041 (4%) Query: 866 YPMSSAQKRMYALYH--LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSF 923 YP++ Q+ M L+H + S++Y + +EG+ + E L +++ +E+LRT+F Sbjct: 11 YPLTPLQEGM--LFHAVTDTGSSAYCLQMSATIEGDFHLPLFEKSLNKLVENYEVLRTAF 68 Query: 924 -HMIHHEPVQVVHDTIDFSIDYTEEKIDDI-RLEADRFIQP-------FDLDTSPLFRVK 974 + P QVV ++ E I + E D +IQ FDL L + Sbjct: 69 VYQNMQRPRQVVFKERKVTVPC--ENIAHLPSAEQDAYIQAYTKQHHAFDLTKDNLMKAA 126 Query: 975 IIKIASRHYLFMFDMHHIISDGISIGLFIKEL-----ALLYGNAVLPEPEIQFKDFSVWE 1029 I + A Y ++ HHII DG ++G+ + +L AL G + E + ++ W Sbjct: 127 IFQTAENKYRLVWAFHHIIVDGWTLGVLLHKLLTYYAALRKGEPIPREATKPYSEYIKWL 186 Query: 1030 KESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKE 1089 + +N D + +W G P YE + FT+ E T++L + Sbjct: 187 DK--QNKD--EALAYWQNYLAGYDHQAAFPKKKLGTEASRYEHVEAMFTIAPEKTQQLIQ 242 Query: 1090 LAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVT-RRRQVE-LESVMGMFSNTLAMR 1147 +A N AT+ + AL+ I+ S N +D++ GS V+ R Q++ +ES++G+F NT+ R Sbjct: 243 IANQNQATMSSVFQALWGILASTYKNADDVVFGSVVSGRPPQIQGIESMVGLFINTIPTR 302 Query: 1148 NFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEM--ISKLDIVRDTGRNPLFDAMLILQN 1205 + F + L V+ AL+ + Y F + I +++ L D ++ +N Sbjct: 303 VQTNKQQTFSELLQTVQKQALA---SATYDFAPLYEIQSTTVLKQE----LIDHLVTFEN 355 Query: 1206 IAVNQFQFGEMKVSF---YEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVET 1262 + + E + F E + +D+ + L+ Y +++ V Sbjct: 356 YPDHSMKHLEESLGFQFTVESGDEQTSYDLNVVVALAPSNELYVKLSYNAAVYESSFVNR 415 Query: 1263 MIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSFDLPADQTIHGLFEEQAK 1321 + +L+ +++QVI + + + +I +++E QQ+L A+N T+ + P D+TI L EQA Sbjct: 416 IEGHLRTVIDQVIGNPHVHLHEIGIITEEEKQQLLVAYNDTAAEYPRDKTIFELIAEQAS 475 Query: 1322 RRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGIL 1381 R + A+ + T++Y EL +R+ QLA LREKG+ +GS+V +M E S E+++ + +L Sbjct: 476 RTPAKAAVVCGEDTLTYQELMERSAQLANALREKGIASGSIVSIMAEHSLELIVAIMAVL 535 Query: 1382 KSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGS 1441 +SG AYLPIDP+YP +RI+++++DS L+LTQ+ + F G V+ L+ L + Sbjct: 536 RSGAAYLPIDPEYPQDRIQYLLDDSQTTLLLTQSHLQPNIRFAGSVLYLDDRSLYEGGST 595 Query: 1442 NLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVN-LTASNKEQLKIQDRERVVQFSSI 1500 + ++ DLAYMIYTSG+TG PKG ++ H+G+VN + +NK ++ + + + +SSI Sbjct: 596 SFAPESKPDDLAYMIYTSGSTGNPKGAMITHQGLVNYIWWANKVYVQGEAVDFPL-YSSI 654 Query: 1501 SFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYLANLN--PN 1558 SFD+++ I +L G T+ + + + N++ L PT+L + Sbjct: 655 SFDLTVTSIFTPLLSGNTIHVYRGA--DKVQVILDIIKDNKVGIIKLTPTHLKLIEHIDG 712 Query: 1559 NIHTVDKMITIGSAISSGLVNE----WKRKCEYINAYGPTETTVYSSVWIANKQGEVDDP 1614 ++ + I G + + L + + + N YGPTET V +++ + Q + Sbjct: 713 KASSIRRFIVGGENLPTKLAKQIYDHFGENVQIFNEYGPTETVVGCMIYLYDPQTTTQES 772 Query: 1615 VPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRI 1674 VPIG P N Q+Y+LD PVG GE+ I G G+ +GY+ RPE+T +K I Sbjct: 773 VPIGVPADNVQLYLLDASMQPVPVGSLGEMYIAGDGVAKGYFNRPELTKEKFIDNPFRPG 832 Query: 1675 GKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKN 1734 K+YRTGDLA+WLPDGN+EY GRMD QVKIRG R+E EI+ L + E +K+ +V K+ Sbjct: 833 TKMYRTGDLAKWLPDGNMEYAGRMDYQVKIRGHRIEMGEIETRLTQHEAVKEAVVIVEKD 892 Query: 1735 QLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPV 1794 + + AY +S + +V ELR+ L LP +MIP++F+R+ PLT+NGK+++K LP Sbjct: 893 ESGQNVLYAYLVSERELTVAELREFLGRTLPSYMIPSFFIRLAEIPLTANGKVERKKLPK 952 Query: 1795 PENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGK 1854 P ++ + Y P+NEIE LAE+W++VL + +VGI D+FF++GG SLKAM V + K Sbjct: 953 PAGAVVTGTAYAAPQNEIEAKLAEIWQQVLGISQVGIHDDFFDLGGHSLKAMTVVFQVSK 1012 Query: 1855 H-RLHMEIKDLFHRQKIAELS 1874 + + +K LF +AEL+ Sbjct: 1013 ALEVELPVKALFEHPTVAELA 1033 >P0C064.2 GRSB_BREBE Gramicidin S synthetase 2 ATP-dependent proline adenylase ATP-dependent valine adenylase ATP-dependent ornithine adenylase ATP-dependent leucine adenylase Length = 4450 Score = 1364 bits (3530), Expect = 0.0, Method: Compositional matrix adjust. Identities = 795/2153 (36%), Positives = 1232/2153 (57%), Gaps = 117/2153 (5%) Query: 9 NVLLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDG--LFQQ 65 N LL + ++K++ YWLN + TD P + +GK R G L Sbjct: 1226 NRLLQSDVIEKQEAYWLNVFTEEIPVLNLPTDYPRPTIQSFDGK---RFTFSTGKQLMDD 1282 Query: 66 LQHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPI 121 L ++ + +LY +LL A + K++ I V +P+ + D + + + + I Sbjct: 1283 LYKVATETGTTLYMVLLAAYNVFLSKYSGQDDIVVGTPIAGRSHADVENMLGMFVNTLAI 1342 Query: 122 IDTFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTN- 180 TF++ L V++T L AY++ DYPFD ++E + D + + + +L N Sbjct: 1343 RSRLNNEDTFKDFLANVKQTALHAYENPDYPFDTLVEKLGIQRDLSRNPLFDTMFVLQNT 1402 Query: 181 ------IHNDAVIPDVGS------NIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQY 228 + + P V + ++ + + I L L Y K FT V ++A + Sbjct: 1403 DRKSFEVEQITITPYVPNSRHSKFDLTLEVSEEQNEILLCLEYCTKLFTDKTVERMAGHF 1462 Query: 229 FQILKGAAENVSIKLGSMXXXXXXXXXXXXXX---QTRTYQNMEDMTLYELFEKQVRQTP 285 QIL N +I + + TY +M+ T+ LFE+QV +TP Sbjct: 1463 LQILHAIVGNPTIIISEIEILSEEEKQHILFEFNDTKTTYPHMQ--TIQGLFEEQVEKTP 1520 Query: 286 DHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSG 345 DHVAV + +Q++TYR+LN +AN++ARVLR +GV + IVGLLVERS +M GI+GILK+G Sbjct: 1521 DHVAVGWKDQALTYRELNERANQVARVLRQKGVQPDNIVGLLVERSPEMLVGIMGILKAG 1580 Query: 346 AAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLD 405 AYLPLD + P +R+ ++I+D G+ + ++ +Q L D + LD+D L + +S Sbjct: 1581 GAYLPLDPEYPADRISYMIQDCGVRIMLT-QQHLLSLVHDEFDCVILDEDSLYKGDSSNL 1639 Query: 406 LILGRALDHPAYVIYTSGTTGQPKGVIIEHRSI------SNTIQWRKSEYSFDASDRMLQ 459 + +A D AY++YTSG+TG+PKGV++EHR++ +N +Q R+ DR++Q Sbjct: 1640 APVNQAGDL-AYIMYTSGSTGKPKGVMVEHRNVIRLVKNTNYVQVRED-------DRIIQ 1691 Query: 460 LFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALL 519 + FD F ++ GA + + + D + + + ++IT L++ L Sbjct: 1692 TGAIGFDALTFEVFGSLLHGAELYPVTKDVLLDAEKLHKFLQANQITIMWLTSPLFNQLS 1751 Query: 520 RNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPD 579 + + E LR + + G+ ++P + K+ P + + N YGPTE++ +T K Sbjct: 1752 QGTE-EMFAGLRSLIVGGDALSPKHINNVKRKCPNLTMWNGYGPTENTTFSTCFLIDKEY 1810 Query: 580 DTELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPF 639 D + IGK I N+ VYI+ +L+ G+ GELC+ G G+ARGY++ LT +KFV NPF Sbjct: 1811 DDNIPIGKAISNSTVYIMDRYGQLQPVGVPGELCVGGDGVARGYMNQPALTEEKFVPNPF 1870 Query: 640 EANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVAL 699 ERMYRTGDLARW G IE +GR D QVK+RGYRIE GEIE L+++ + E+V+ + Sbjct: 1871 APGERMYRTGDLARWLPDGTIEYLGRIDQQVKIRGYRIEPGEIETLLVKHKKVKESVIMV 1930 Query: 700 WEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNA 759 ED N +CAY V + ++ ELRE ++K LP YM+P +F Q+EQ P+T GK++R+A Sbjct: 1931 VEDNNGQKALCAYYVPEEEVTVSELREYIAKELPVYMVPAYFVQIEQMPLTQNGKVNRSA 1990 Query: 760 LRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSR 819 L + P+++IE +L EIW NVL V+K+ + DNFF LGGHSL+A ++S+ Sbjct: 1991 LPKPDGEFGTATEYVAPSSDIEMKLAEIWHNVLGVNKIGVLDNFFELGGHSLRAMTMISQ 2050 Query: 820 LHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALY 879 +HKEF VE+ L +FE TI LA I G Y +I P +DYYP+SSAQKRMY LY Sbjct: 2051 VHKEFDVELPLKVLFETPTISALAQYIADGEKGMYLAIQPVTPQDYYPVSSAQKRMYILY 2110 Query: 880 HLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTID 939 EG +YN+P VM +EG+LD + E ++ +I+RHE LRTSF+ ++ EPVQ VH ++ Sbjct: 2111 EFEGAGITYNVPNVMFIEGKLDYQRFEYAIKSLINRHEALRTSFYSLNGEPVQRVHQNVE 2170 Query: 940 FSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISI 999 I Y+E K D+I + F+QPFDL+ +P RV ++K+AS +LF+ DMHHIISDG+S+ Sbjct: 2171 LQIAYSEAKEDEIEQIVESFVQPFDLEIAPALRVGLVKLASDRHLFLMDMHHIISDGVSM 2230 Query: 1000 GLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELP 1059 + KE+A LY L E IQ+KDF+VW+ E ++ ++Q+ +WL F ++P+L L Sbjct: 2231 QIITKEIADLYKGKELAELHIQYKDFAVWQNEWFQSAALEKQKTYWLNTFAEDIPVLNLS 2290 Query: 1060 VDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDI 1119 DY RP +S+EG + F+ K+ +LK LA + G TLYMLLLA +N++L K + QE+I Sbjct: 2291 TDYPRPTIQSFEGDIVTFSAGKQLAEELKRLATETGTTLYMLLLAAYNVLLHKYSGQEEI 2350 Query: 1120 IVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFE 1179 +VG+P+ R ++E+++GMF NTLA++N P + F +FL EVK +AL AF+NQDY FE Sbjct: 2351 VVGTPIAGRSHADVENIVGMFVNTLALKNTPIAVRTFHEFLLEVKQNALEAFENQDYPFE 2410 Query: 1180 EMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSF--YEHEHNISRFDITLHCL 1237 +I KL + RD RNPLFD M L NI Q + G +SF YE ++ I++FDI+ L Sbjct: 2411 NLIEKLQVRRDLSRNPLFDTMFSLSNID-EQVEIGIEGLSFSPYEMQYWIAKFDISFDIL 2469 Query: 1238 EGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL 1297 E D + F YCT LFK+ET+E + + I+ +++ + EI++ +I M+SE Q++L Sbjct: 2470 EKQDDI-QFYFNYCTNLFKKETIERLATHFMHILQEIVINPEIKLCEINMLSEEEQQRVL 2528 Query: 1298 A-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKG 1356 FN T ++ H LFEEQ ++ D A+ + +SY ELN +ANQLAR+LR+KG Sbjct: 2529 YDFNGTDATYATNKIFHELFEEQVEKTPDHIAVIDEREKLSYQELNAKANQLARVLRQKG 2588 Query: 1357 VTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNI 1416 V S+VG+M +RS +M++G LG+LK+GGAY+PID DYP ERI +M+EDSG L+LTQ Sbjct: 2589 VQPNSMVGIMVDRSLDMIVGMLGVLKAGGAYVPIDIDYPQERISYMMEDSGAALLLTQQK 2648 Query: 1417 PYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIV 1476 + F G+++ L+ + + SNL I R D+AY+IYTSGTTGKPKG ++EH+ V Sbjct: 2649 LTQQIAFSGDILYLDQEEWLHEEASNLEPIARPQDIAYIIYTSGTTGKPKGVMIEHQSYV 2708 Query: 1477 NLTASNKEQLKIQDRE-RVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEA 1535 N+ + K+ ++ R++Q +S +FDVS D + ++L GG L + E+ D + A Sbjct: 2709 NVAMAWKDAYRLDTFPVRLLQMASFAFDVSAGDFARALLTGGQLIVCPNEVKMDPASLYA 2768 Query: 1536 FLNSNRIT------AAILP---PTYLANLNPNNIHTVDKMITIGSAISS-----GLVNEW 1581 + IT A ++P Y L+ + + +++ +GS S LV+ + Sbjct: 2769 IIKKYDITIFEATPALVIPLMEYIYEQKLDISQL----QILIVGSDSCSMEDFKTLVSRF 2824 Query: 1582 KRKCEYINAYGPTETTVYSSVWIANKQG-EVDDPVPIGKPILNTQMYILDKYRNLQPVGI 1640 +N+YG TE + SS + V VPIGKP N +MYI+++Y +QPVG+ Sbjct: 2825 GSTIRIVNSYGVTEACIDSSYYEQPLSSLHVTGTVPIGKPYANMKMYIMNQYLQIQPVGV 2884 Query: 1641 PGELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDE 1700 GELCIGG G+ RGY RP++TA+K + K+YRTGDLARW+PDGN+E+LGR D Sbjct: 2885 IGELCIGGAGVARGYLNRPDLTAEKFVPNPFVPGEKLYRTGDLARWMPDGNVEFLGRNDH 2944 Query: 1701 QVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQL 1760 QVKIRG R+E EI+A+L K + IK+ V R++ ++ +CAY ++ + +V ELR L Sbjct: 2945 QVKIRGIRIELGEIEAQLRKHDSIKEATVIAREDHMKEKYLCAYMVTEGEVNVAELRAYL 3004 Query: 1761 LSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVW 1820 + LP MIP+YFV +EA PLT+NGKID++ LP P+ S+ + Y+ PR +E L E+W Sbjct: 3005 ATDLPAAMIPSYFVSLEAMPLTANGKIDKRSLPEPDGSISIGTEYVAPRTMLEGKLEEIW 3064 Query: 1821 EEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDL 1880 ++VL L++VGI D+FF +GG SLKAM V + + H++ E+ +R L Sbjct: 3065 KDVLGLQRVGIHDDFFTIGGHSLKAMAVISQV-------------HKECQTEVP--LRVL 3109 Query: 1881 RNNPIVENPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAV 1940 P ++ I+ + TE +I+ + Q+ S + + Sbjct: 3110 FETPTIQGLAKYIEETDTEQYMAIQ--------PVSGQDYYPVSSAQKRMFIVNQFDGVG 3161 Query: 1941 QKYHLMNAEKVHTSIPFRSCGDIGKIQKAILRLVNEQVLLRSV--IVNDGENTYFYEHGS 1998 Y++ + + + + +++ A RL+ LR+ I+N +E Sbjct: 3162 ISYNMPSIMLIEGKL------ERTRLESAFKRLIERHESLRTSFEIINGKPVQKIHEEAD 3215 Query: 1999 VYNLPFILIDLSGFDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYS 2058 +N+ + +E + + D F + PF+ L R+ L++ + ++L++ Sbjct: 3216 -FNMSY---------QVASNEQVEKMIDEFIQ-PFDLSVAPLLRVELLKLEEDRHVLIFD 3264 Query: 2059 ADHAVSDGLSLGIITDQLAAYFAGDSSLPVHSLKHH-----QNYWDYADQMQK 2106 H +SDG+S I+ +L + G+ +LP +++ QN W ++ +K Sbjct: 3265 MHHIISDGISSNILMKELGELYQGN-ALPELRIQYKDFAVWQNEWFQSEAFKK 3316 Score = 1339 bits (3465), Expect = 0.0, Method: Compositional matrix adjust. Identities = 745/1928 (38%), Positives = 1134/1928 (58%), Gaps = 61/1928 (3%) Query: 9 NVLLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQ 67 N ++ ++K+K YWLN + TD P + EG + + L ++L+ Sbjct: 2261 NEWFQSAALEKQKTYWLNTFAEDIPVLNLSTDYPRPTIQSFEG-DIVTFSAGKQLAEELK 2319 Query: 68 HLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPIID 123 L+ + +LY +LL A L+ K++ I V +P+ + D + + + + + + Sbjct: 2320 RLATETGTTLYMLLLAAYNVLLHKYSGQEEIVVGTPIAGRSHADVENIVGMFVNTLALKN 2379 Query: 124 TFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHN 183 T TF E LL+V++ L A+++QDYPF+ +IE +Q D + + + L+NI Sbjct: 2380 TPIAVRTFHEFLLEVKQNALEAFENQDYPFENLIEKLQVRRDLSRNPLFDTMFSLSNIDE 2439 Query: 184 DAVIPDVG--------------SNIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYF 229 I G +I F I Y F + + +LA + Sbjct: 2440 QVEIGIEGLSFSPYEMQYWIAKFDISFDILEKQDDIQFYFNYCTNLFKKETIERLATHFM 2499 Query: 230 QILKGAAENVSIKLGSMXXXXXXXXXXXXXX---QTRTYQNMEDMTLYELFEKQVRQTPD 286 IL+ N IKL + TY + +ELFE+QV +TPD Sbjct: 2500 HILQEIVINPEIKLCEINMLSEEEQQRVLYDFNGTDATYAT--NKIFHELFEEQVEKTPD 2557 Query: 287 HVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGA 346 H+AV + ++Y++LNAKAN+LARVLR +GV N +VG++V+RS+DM G+LG+LK+G Sbjct: 2558 HIAVIDEREKLSYQELNAKANQLARVLRQKGVQPNSMVGIMVDRSLDMIVGMLGVLKAGG 2617 Query: 347 AYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDL 406 AY+P+DI P+ER+ +++ED+G + ++ ++ +++ G ++ LD + L E+ Sbjct: 2618 AYVPIDIDYPQERISYMMEDSGAALLLTQQKLTQQIAFSG-DILYLDQEEWLHEEASNLE 2676 Query: 407 ILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASD-RMLQLFSYIF 465 + R D AY+IYTSGTTG+PKGV+IEH+S N K Y D R+LQ+ S+ F Sbjct: 2677 PIARPQD-IAYIIYTSGTTGKPKGVMIEHQSYVNVAMAWKDAYRLDTFPVRLLQMASFAF 2735 Query: 466 DGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPE 525 D F +++G ++ DP ++ +I + IT F A P L L+ + + Sbjct: 2736 DVSAGDFARALLTGGQLIVCPNEVKMDPASLYAIIKKYDITIFEATPALVIPLMEYIYEQ 2795 Query: 526 --EAQSLRIVTLAGEKVT-PNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDT- 581 + L+I+ + + + + + + IVN YG TE+ + ++ +P + Sbjct: 2796 KLDISQLQILIVGSDSCSMEDFKTLVSRFGSTIRIVNSYGVTEACIDSSYYE--QPLSSL 2853 Query: 582 ----ELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSN 637 + IGKP N ++YI+ L+++ G++GELCI GAG+ARGYL+ LT +KFV N Sbjct: 2854 HVTGTVPIGKPYANMKMYIMNQYLQIQPVGVIGELCIGGAGVARGYLNRPDLTAEKFVPN 2913 Query: 638 PFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVV 697 PF E++YRTGDLARW G +E +GR D QVK+RG RIELGEIE +L +++ I EA V Sbjct: 2914 PFVPGEKLYRTGDLARWMPDGNVEFLGRNDHQVKIRGIRIELGEIEAQLRKHDSIKEATV 2973 Query: 698 ALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDR 757 ED +CAY+V + ++ ELR L+ LP M+P++F LE P+T GK+D+ Sbjct: 2974 IAREDHMKEKYLCAYMVTEGEVNVAELRAYLATDLPAAMIPSYFVSLEAMPLTANGKIDK 3033 Query: 758 NALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLL 817 +L +G + P +E +L EIWK+VL + +V IHD+FF +GGHSLKA ++ Sbjct: 3034 RSLPEPDGSISIGTEYVAPRTMLEGKLEEIWKDVLGLQRVGIHDDFFTIGGHSLKAMAVI 3093 Query: 818 SRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYA 877 S++HKE Q E+ L +FE TI LA I+ Y +I P +DYYP+SSAQKRM+ Sbjct: 3094 SQVHKECQTEVPLRVLFETPTIQGLAKYIEETDTEQYMAIQPVSGQDYYPVSSAQKRMFI 3153 Query: 878 LYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDT 937 + +G SYNMP +M++EG+L+ ++ES +++I RHE LRTSF +I+ +PVQ +H+ Sbjct: 3154 VNQFDGVGISYNMPSIMLIEGKLERTRLESAFKRLIERHESLRTSFEIINGKPVQKIHEE 3213 Query: 938 IDFSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGI 997 DF++ Y + + D FIQPFDL +PL RV+++K+ ++ +FDMHHIISDGI Sbjct: 3214 ADFNMSYQVASNEQVEKMIDEFIQPFDLSVAPLLRVELLKLEEDRHVLIFDMHHIISDGI 3273 Query: 998 SIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLE 1057 S + +KEL LY LPE IQ+KDF+VW+ E ++ FK+QEE+W+ +F E P+L+ Sbjct: 3274 SSNILMKELGELYQGNALPELRIQYKDFAVWQNEWFQSEAFKKQEEYWVNVFADERPILD 3333 Query: 1058 LPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQE 1117 +P DY RP+ +S++G+++ F K+ L +A + G TLYM+LLA +N++LSK + QE Sbjct: 3334 IPTDYPRPMQQSFDGAQLTFGTGKQLMDGLYRVATETGTTLYMVLLAAYNVLLSKYSGQE 3393 Query: 1118 DIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQ 1177 DIIVG+P+ R +LE+++GMF NTLAMRN P G K FK F++E+K +AL+AF+NQDY Sbjct: 3394 DIIVGTPIVGRSHTDLENIVGMFVNTLAMRNKPEGEKTFKAFVSEIKQNALAAFENQDYP 3453 Query: 1178 FEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMK------VSFYEHEHNISRFD 1231 FEE+I KL+I RD RNPLFD + LQNI F+ E+ VS EH ++FD Sbjct: 3454 FEELIEKLEIQRDLSRNPLFDTLFSLQNIGEESFELAELTCKPFDLVSKLEH----AKFD 3509 Query: 1232 ITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSEN 1291 ++L +E + + +YCT+L+K +TVE + + IV ++ + ++++SDI M+SE Sbjct: 3510 LSLVAVEKEEEIAF-GLQYCTKLYKEKTVEQLAQHFIQIVKAIVENPDVKLSDIDMLSEE 3568 Query: 1292 AVQQI-LAFNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLAR 1350 +QI L FN T P +QTI LFEEQ K+ + A+ + Q ++Y ELN +ANQLAR Sbjct: 3569 EKKQIMLEFNDTKIQYPQNQTIQELFEEQVKKTPEHIAIVWEGQALTYHELNIKANQLAR 3628 Query: 1351 LLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQL 1410 +LREKGVT V +M ERS EM++G ILK+GGAY+PIDP YP ERI++++EDSG L Sbjct: 3629 VLREKGVTPNHPVAIMTERSLEMIVGIFSILKAGGAYVPIDPAYPQERIQYLLEDSGATL 3688 Query: 1411 VLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLL 1470 +LTQ+ N L D E +DL DG+NLP +N+S+DLAY+IYTSGTTGKPKG ++ Sbjct: 3689 LLTQSHVLNKLPVDIEWLDLTDEQNYVEDGTNLPFMNQSTDLAYIIYTSGTTGKPKGVMI 3748 Query: 1471 EHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDN 1530 EH+ I+N KE+ + + +Q S +FD + + IL G T L +E D Sbjct: 3749 EHQSIINCLQWRKEEYEFGPGDTALQVFSFAFDGFVASLFAPILAGATSVLPKEEEAKDP 3808 Query: 1531 SCFEAFLNSNRITAAI-LPPTYLANLNPNNIHTVDKM--ITIGS----AISSGLVNEWKR 1583 + + S IT +P + A L+ ++ + + +T+G A + E + Sbjct: 3809 VALKKLIASEEITHYYGVPSLFSAILDVSSSKDLQNLRCVTLGGEKLPAQIVKKIKEKNK 3868 Query: 1584 KCEYINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGE 1643 + E N YGPTE +V +++ + +V+ + IG P+ N +YI++ LQPVG+ GE Sbjct: 3869 EIEVNNEYGPTENSVVTTIM---RDIQVEQEITIGCPLSNVDVYIVNCNHQLQPVGVVGE 3925 Query: 1644 LCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVK 1703 LCIGG GL RGY +PE+TADK + ++Y+TGDLA+W DG +EY+GR+DEQVK Sbjct: 3926 LCIGGQGLARGYLNKPELTADKFVVNPFVPGERMYKTGDLAKWRSDGMIEYVGRVDEQVK 3985 Query: 1704 IRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSK 1763 +RG+R+E EI++ +L+ E IK+ +V ++ +CAY + D +LR L Sbjct: 3986 VRGYRIELGEIESAILEYEKIKEAVVIVSEHTASEQMLCAYIVGEEDVLTLDLRSYLAKL 4045 Query: 1764 LPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEV 1823 LP +MIP YF+++++ PLT NGK+D+K LP P+ Y+ PRNEIE L +W+EV Sbjct: 4046 LPSYMIPNYFIQLDSIPLTPNGKVDRKALPEPQTIGLMAREYVAPRNEIEAQLVLIWQEV 4105 Query: 1824 LRLEKVGIEDNFFEVGGDSLKA-MQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRN 1882 L +E +GI DNFFE+GG SLKA + VA I ++ M + +F I +++E + + Sbjct: 4106 LGIELIGITDNFFELGGHSLKATLLVAKIYEYMQIEMPLNVVFKHSTIMKIAEYITHQES 4165 Query: 1883 NPIVENPV 1890 V P+ Sbjct: 4166 ENNVHQPI 4173 Score = 1322 bits (3422), Expect = 0.0, Method: Compositional matrix adjust. Identities = 747/2139 (34%), Positives = 1221/2139 (57%), Gaps = 101/2139 (4%) Query: 12 LSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKE--SLRLDIPDGLFQQLQHL 69 L + ++ +YW ++ D + K+A+ E R L QQL + Sbjct: 190 LEKQDKQEALRYWKEHLMNY--DQSVTLPKKKAAINNTTYEPAQFRFAFDKVLTQQLLRI 247 Query: 70 SNRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEA------YNHYVPIID 123 +N+S +L + T ++ K+ ++ + S V + S + + +P+ Sbjct: 248 ANQSQVTLNIVFQTIWGIVLQKYNSTNDVVYGSVVSGRPSEISGIEKMVGLFINTLPLRI 307 Query: 124 TFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLC-----LL 178 +F E + V + L + H+ +P + ++Q ++ + + H++ L+ Sbjct: 308 QTQKDQSFIELVKTVHQNVLFSQQHEYFP----LYEIQNHTELKQNLIDHIMVIENYPLV 363 Query: 179 TNIHNDAVIPDVGSNI--------------VFGFTRDDAGISLNLIYNLKYFTRNFVMQL 224 + ++++ VG + V RD+ IS+ L YN + +F+ ++ Sbjct: 364 EELQKNSIMQKVGFTVRDVKMFEPTNYDMTVMVLPRDE--ISVRLDYNAAVYDIDFIRKI 421 Query: 225 AKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQVRQT 284 ++ A N + + + + D T+++LF +QV +T Sbjct: 422 EGHMKEVALCVANNPHVLVQDVPLLTKQEKQHLLVELHDSITEYPDKTIHQLFTEQVEKT 481 Query: 285 PDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKS 344 P+HVAV F ++ +TYR+L+ ++N+LAR LR +GV I+G+++ERS++M GILGILK+ Sbjct: 482 PEHVAVVFEDEKVTYRELHERSNQLARFLREKGVKKESIIGIMMERSVEMIVGILGILKA 541 Query: 345 GAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDL 404 G A++P+D + P+ER+ ++++ + + ++ + ++K T++ D + E ++ Sbjct: 542 GGAFVPIDPEYPKERIGYMLD--SVRLVLTQRHLKDKFAFTKETIVIEDPSISHELTEEI 599 Query: 405 DLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYI 464 D I + Y+IYTSGTTG+PKGV++EH++I N + + + + + SD++LQ + Sbjct: 600 DYI--NESEDLFYIIYTSGTTGKPKGVMLEHKNIVNLLHFTFEKTNINFSDKVLQYTTCS 657 Query: 465 FDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKP 524 FD F+ ++SG + + + RD + L+ I ++ P + + N + Sbjct: 658 FDVCYQEIFSTLLSGGQLYLIRKETQRDVEQLFDLVKRENI-EVLSFPVAFLKFIFNERE 716 Query: 525 ---EEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDT 581 ++ + AGE++ N + + N YGP+E+ V+ T + + + Sbjct: 717 FINRFPTCVKHIITAGEQLVVNNEFKRYLHEHNVHLHNHYGPSETHVVTTYTINPEAEIP 776 Query: 582 ELT-IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFE 640 EL IGKPI NT +YI+ +L+ G+VGEL ISGA + RGYL+N+ LT +KF ++PF Sbjct: 777 ELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGANVGRGYLNNQELTAEKFFADPFR 836 Query: 641 ANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALW 700 NERMYRTGDLARW G IE +GRAD QVK+RG+RIELGEIE +LL G+ EAVV Sbjct: 837 PNERMYRTGDLARWLPDGNIEFLGRADHQVKIRGHRIELGEIEAQLLNCKGVKEAVVIDK 896 Query: 701 EDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNAL 760 D +CAY+V + ++ ELRE L K+LP+YM+P+ F L+Q P+TP GK+DR +L Sbjct: 897 ADDKGGKYLCAYVVMEVEVNDSELREYLGKALPDYMIPSFFVPLDQLPLTPNGKIDRKSL 956 Query: 761 RNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRL 820 N + + A++ PTNE+E +L +IW+ VL + ++ I DNFF LGGHSLKA L+SR+ Sbjct: 957 PNLEGIVNTNAKYVVPTNELEEKLAKIWEEVLGISQIGIQDNFFSLGGHSLKAITLISRM 1016 Query: 821 HKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYH 880 +KE V+I L +FE TI ++ I + +Y +I P +++YYP+SS QKRM+ L Sbjct: 1017 NKECNVDIPLRLLFEAPTIQEISNYINGAKKESYVAIQPVPEQEYYPVSSVQKRMFILNE 1076 Query: 881 LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDF 940 + T+YN+P VM ++G+L+ Q+E+ +++++ RHE LRTSFH I+ EPVQ VH ++ Sbjct: 1077 FDRSGTAYNLPGVMFLDGKLNYRQLEAAVKKLVERHEALRTSFHSINGEPVQRVHQNVEL 1136 Query: 941 SIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIG 1000 I Y+E D + F+QPF L+ +PL RV ++K+ + +LF+ DMHHIISDG+S+ Sbjct: 1137 QIAYSESTEDQVERIIAEFMQPFALEVAPLLRVGLVKLEAERHLFIMDMHHIISDGVSMQ 1196 Query: 1001 LFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPV 1060 + I+E+A LY LP IQ+KDF+VW ++ ++QE +WL +F E+P+L LP Sbjct: 1197 IMIQEIADLYKEKELPTLGIQYKDFTVWHNRLLQSDVIEKQEAYWLNVFTEEIPVLNLPT 1256 Query: 1061 DYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDII 1120 DY RP +S++G + F+ K+ L ++A + G TLYM+LLA +N+ LSK + Q+DI+ Sbjct: 1257 DYPRPTIQSFDGKRFTFSTGKQLMDDLYKVATETGTTLYMVLLAAYNVFLSKYSGQDDIV 1316 Query: 1121 VGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEE 1180 VG+P+ R ++E+++GMF NTLA+R+ FKDFL VK +AL A++N DY F+ Sbjct: 1317 VGTPIAGRSHADVENMLGMFVNTLAIRSRLNNEDTFKDFLANVKQTALHAYENPDYPFDT 1376 Query: 1181 MISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGL 1240 ++ KL I RD RNPLFD M +LQN F+ ++ ++ Y S+FD+TL E Sbjct: 1377 LVEKLGIQRDLSRNPLFDTMFVLQNTDRKSFEVEQITITPYVPNSRHSKFDLTLEVSEEQ 1436 Query: 1241 DGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AF 1299 + +L C EYCT+LF +TVE M + I++ ++ + I IS+I ++SE Q IL F Sbjct: 1437 NEILLC-LEYCTKLFTDKTVERMAGHFLQILHAIVGNPTIIISEIEILSEEEKQHILFEF 1495 Query: 1300 NQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTA 1359 N T P QTI GLFEEQ ++ D A+ + DQ ++Y ELN+RANQ+AR+LR+KGV Sbjct: 1496 NDTKTTYPHMQTIQGLFEEQVEKTPDHVAVGWKDQALTYRELNERANQVARVLRQKGVQP 1555 Query: 1360 GSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYN 1419 ++VGL+ ERS EM++G +GILK+GGAYLP+DP+YP +RI +MI+D G++++LTQ + Sbjct: 1556 DNIVGLLVERSPEMLVGIMGILKAGGAYLPLDPEYPADRISYMIQDCGVRIMLTQQHLLS 1615 Query: 1420 WLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLT 1479 + + + + L+ L D SNL +N++ DLAY++YTSG+TGKPKG ++EH+ ++ L Sbjct: 1616 LVHDEFDCVILDEDSLYKGDSSNLAPVNQAGDLAYIMYTSGSTGKPKGVMVEHRNVIRL- 1674 Query: 1480 ASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNS 1539 N +++++ +R++Q +I FD ++ S+L G L TK++L D FL + Sbjct: 1675 VKNTNYVQVREDDRIIQTGAIGFDALTFEVFGSLLHGAELYPVTKDVLLDAEKLHKFLQA 1734 Query: 1540 NRITAAILPPTYLANLNPNN---IHTVDKMITIGSAISSGLVNEWKRKCEYI---NAYGP 1593 N+IT L L+ + +I G A+S +N KRKC + N YGP Sbjct: 1735 NQITIMWLTSPLFNQLSQGTEEMFAGLRSLIVGGDALSPKHINNVKRKCPNLTMWNGYGP 1794 Query: 1594 TETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTR 1653 TE T +S+ ++ +K E DD +PIGK I N+ +YI+D+Y LQPVG+PGELC+GG G+ R Sbjct: 1795 TENTTFSTCFLIDK--EYDDNIPIGKAISNSTVYIMDRYGQLQPVGVPGELCVGGDGVAR 1852 Query: 1654 GYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQE 1713 GY +P +T +K + + ++YRTGDLARWLPDG +EYLGR+D+QVKIRG+R+EP E Sbjct: 1853 GYMNQPALTEEKFVPNPFAPGERMYRTGDLARWLPDGTIEYLGRIDQQVKIRGYRIEPGE 1912 Query: 1714 IKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYF 1773 I+ L+K + +K+ ++ ++ ++CAYY+ + +V+ELR+ + +LP +M+PAYF Sbjct: 1913 IETLLVKHKKVKESVIMVVEDNNGQKALCAYYVPEEEVTVSELREYIAKELPVYMVPAYF 1972 Query: 1774 VRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIED 1833 V++E PLT NGK+++ LP P+ + Y+ P ++IE+ LAE+W VL + K+G+ D Sbjct: 1973 VQIEQMPLTQNGKVNRSALPKPDGEFGTATEYVAPSSDIEMKLAEIWHNVLGVNKIGVLD 2032 Query: 1834 NFFEVGGDSLKAM-QVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGR 1892 NFFE+GG SL+AM ++ + + + + +K LF I+ L++ + D Sbjct: 2033 NFFELGGHSLRAMTMISQVHKEFDVELPLKVLFETPTISALAQYIAD------------- 2079 Query: 1893 IDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVH 1952 G +G + + + Q+ S + + A Y++ N + Sbjct: 2080 ----GEKG-------MYLAIQPVTPQDYYPVSSAQKRMYILYEFEGAGITYNVPNVMFIE 2128 Query: 1953 TSIPFRSCGDIGKIQKAILRLVNEQVLLRSVIVNDGENTYFYEHGSVYNLPFILIDLS-G 2011 + D + + AI L+N LR+ +++ +G ++L Sbjct: 2129 GKL------DYQRFEYAIKSLINRHEALRT--------SFYSLNGEPVQRVHQNVELQIA 2174 Query: 2012 FDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGI 2071 + A+ E ++ PF+ + R+ LV+ A + ++ L H +SDG+S+ I Sbjct: 2175 YSEAKEDEIEQIVESFVQ--PFDLEIAPALRVGLVKLASDRHLFLMDMHHIISDGVSMQI 2232 Query: 2072 ITDQLAAYFAGDSSLPVH----SLKHHQNYWDYADQMQK 2106 IT ++A + G +H QN W + ++K Sbjct: 2233 ITKEIADLYKGKELAELHIQYKDFAVWQNEWFQSAALEK 2271 Score = 532 bits (1370), Expect = e-148, Method: Compositional matrix adjust. Identities = 386/1278 (30%), Positives = 646/1278 (50%), Gaps = 116/1278 (9%) Query: 863 RDYYPMSSAQKRMYALYH--LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILR 920 +D Y +S Q+ M L+H L+ + ++ + + +EG +DV + L +I R+++ R Sbjct: 10 QDMYRLSPMQEGM--LFHALLDKDKNAHLVQMSIAIEGIVDVELLSESLNILIDRYDVFR 67 Query: 921 TSF-HMIHHEPVQVV----------HDTIDFSIDYTEEKIDDIRLEADRFIQPFDLDTSP 969 T+F H +P+QVV D + E+ I+ + + + FDL P Sbjct: 68 TTFLHEKIKQPLQVVLKERPVQLQFKDISSLDEEKREQAIEQYKYQDGETV--FDLTRDP 125 Query: 970 LFRVKIIKIASRHYLFMFDMHHIISDG----------ISIGLFIKELALLYGNAVLPEPE 1019 L RV I + +Y ++ HHI+ DG +I L +KE L AV P Sbjct: 126 LMRVAIFQTGKVNYQMIWSFHHILMDGWCFNIIFNDLFNIYLSLKEKKPLQLEAVQP--- 182 Query: 1020 IQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTL 1079 +K F W E D ++ +W + + LP + +YE ++ F Sbjct: 183 --YKQFIKW----LEKQDKQEALRYWKEHLMNYDQSVTLPKKKAAINNTTYEPAQFRFAF 236 Query: 1080 DKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQ--VELESVM 1137 DK T++L +A + TL ++ ++ I+L K + D++ GS V+ R +E ++ Sbjct: 237 DKVLTQQLLRIANQSQVTLNIVFQTIWGIVLQKYNSTNDVVYGSVVSGRPSEISGIEKMV 296 Query: 1138 GMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLF 1197 G+F NTL +R ++ F + + V + L + ++ + E+ + ++ ++ L Sbjct: 297 GLFINTLPLRIQTQKDQSFIELVKTVHQNVLFSQQHEYFPLYEIQNHTELKQN-----LI 351 Query: 1198 DAMLILQNIA-VNQFQFGEM--KVSFYEHEHNI---SRFDITLHCLEGLDGLLHCSFEYC 1251 D +++++N V + Q + KV F + + + +D+T+ L + + +Y Sbjct: 352 DHIMVIENYPLVEELQKNSIMQKVGFTVRDVKMFEPTNYDMTVMVLPRDE--ISVRLDYN 409 Query: 1252 TRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILAFNQTSFDLPADQT 1311 ++ + + + ++K + V + + + D+ ++++ Q +L S D+T Sbjct: 410 AAVYDIDFIRKIEGHMKEVALCVANNPHVLVQDVPLLTKQEKQHLLVELHDSITEYPDKT 469 Query: 1312 IHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSF 1371 IH LF EQ ++ + A+ F D+ ++Y EL++R+NQLAR LREKGV S++G+M ERS Sbjct: 470 IHQLFTEQVEKTPEHVAVVFEDEKVTYRELHERSNQLARFLREKGVKKESIIGIMMERSV 529 Query: 1372 EMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLN 1431 EM++G LGILK+GGA++PIDP+YP ERI +M++ ++LVLTQ + F E I + Sbjct: 530 EMIVGILGILKAGGAFVPIDPEYPKERIGYMLD--SVRLVLTQRHLKDKFAFTKETIVIE 587 Query: 1432 CAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDR 1491 +++ + IN S DL Y+IYTSGTTGKPKG +LEHK IVNL E+ I Sbjct: 588 DPSISHELTEEIDYINESEDLFYIIYTSGTTGKPKGVMLEHKNIVNLLHFTFEKTNINFS 647 Query: 1492 ERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTY 1551 ++V+Q+++ SFDV +I ++L GG L L KE D + I P + Sbjct: 648 DKVLQYTTCSFDVCYQEIFSTLLSGGQLYLIRKETQRDVEQLFDLVKRENIEVLSFPVAF 707 Query: 1552 LA---------NLNPNNIHTVDKMITIGSAISSGLVNEWKR-----KCEYINAYGPTETT 1597 L N P V +IT G + NE+KR N YGP+ET Sbjct: 708 LKFIFNEREFINRFPT---CVKHIITAGEQLVVN--NEFKRYLHEHNVHLHNHYGPSETH 762 Query: 1598 VYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWK 1657 V ++ I N + E+ + PIGKPI NT +YILD+ + LQP GI GEL I G + RGY Sbjct: 763 VVTTYTI-NPEAEIPELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGANVGRGYLN 821 Query: 1658 RPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAE 1717 E+TA+K ++YRTGDLARWLPDGN+E+LGR D QVKIRG R+E EI+A+ Sbjct: 822 NQELTAEKFFADPFRPNERMYRTGDLARWLPDGNIEFLGRADHQVKIRGHRIELGEIEAQ 881 Query: 1718 LLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRME 1777 LL +G+K+ +V + + +CAY + ++ + +ELR+ L LP++MIP++FV ++ Sbjct: 882 LLNCKGVKEAVVIDKADDKGGKYLCAYVVMEVEVNDSELREYLGKALPDYMIPSFFVPLD 941 Query: 1778 AFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFE 1837 PLT NGKID+K LP E + ++ Y+ P NE+E LA++WEEVL + ++GI+DNFF Sbjct: 942 QLPLTPNGKIDRKSLPNLEGIVNTNAKYVVPTNELEEKLAKIWEEVLGISQIGIQDNFFS 1001 Query: 1838 VGGDSLKAMQVAAILGKH-RLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSS 1896 +GG SLKA+ + + + K + + ++ LF I E+S I+ + Sbjct: 1002 LGGHSLKAITLISRMNKECNVDIPLRLLFEAPTIQEIS----------------NYINGA 1045 Query: 1897 GTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHTSIP 1956 E +I+ + +QE S++ + + Y+L + + Sbjct: 1046 KKESYVAIQ--------PVPEQEYYPVSSVQKRMFILNEFDRSGTAYNLPGVMFLDGKLN 1097 Query: 1957 FRSCGDIGKIQKAILRLVNEQVLLRSVIVN-DGENTYFYEHGSVYNLPFILIDLSGFDAA 2015 +R +++ A+ +LV LR+ + +GE + + S D Sbjct: 1098 YR------QLEAAVKKLVERHEALRTSFHSINGEPVQRVHQNVELQIAY---SESTEDQV 1148 Query: 2016 RRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQ 2075 R ++Q PF + L R+ LV+ E ++ + H +SDG+S+ I+ + Sbjct: 1149 ERI-IAEFMQ------PFALEVAPLLRVGLVKLEAERHLFIMDMHHIISDGVSMQIMIQE 1201 Query: 2076 LAAYFAGDSSLPVHSLKH 2093 +A + + LP +++ Sbjct: 1202 IADLYK-EKELPTLGIQY 1218 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.320 0.137 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 13,775,421,021 Number of extensions: 596303955 Number of successful extensions: 1595619 Number of sequences better than 1.0e-05: 16366 Number of HSP's gapped: 1466716 Number of HSP's successfully gapped: 33699 Length of query: 2351 Length of database: 3,060,696,203 Length adjustment: 152 Effective length of query: 2199 Effective length of database: 1,628,701,923 Effective search space: 3581515528677 Effective search space used: 3581515528677 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 140 (58.5 bits)