BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0557.0015.p (564 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B1D4J9.1 B1D4J9_9BACL von Willebrand factor type A 873 0.0 B3K3Q6.1 B3K3Q6_9BACI von Willebrand factor type A 871 0.0 A3DK47.1 A3DK47_CLOTH von Willebrand factor, type A 743 0.0 B4BD57.1 B4BD57_CLOTM von Willebrand factor type A 743 0.0 Q8TN39.1 Q8TN39_METAC Putative uncharacterized protein 679 0.0 >B1D4J9.1 B1D4J9_9BACL von Willebrand factor type A Length = 562 Score = 873 bits (2255), Expect = 0.0, Method: Compositional matrix adjust. Identities = 417/562 (74%), Positives = 488/562 (86%) Query: 3 MAEKGKKGIILVVIAASVFALIYFGITLTSNLGKSDKEISAEDAGRKLNKLYKEIDVTVA 62 M K K +I VV+ A VF L+Y G+TLTSNLGKS E++AE+AG +L+KL+K+I T Sbjct: 1 MQRKSKFLLISVVLLAVVFGLVYAGVTLTSNLGKSKAEVTAENAGDRLSKLFKKISPTTE 60 Query: 63 DTVKGQIDLDPADIGGSLPDIAKFPVSVDNTTDSFVEIFSSTEKSGTGNDGWLNEVAAAF 122 VKGQIDLDP D+ SLPDI KFP++V+NT D+FVEIFSSTEKSGTG DGWL +VA F Sbjct: 61 TPVKGQIDLDPVDVAASLPDINKFPITVNNTNDNFVEIFSSTEKSGTGVDGWLTDVATEF 120 Query: 123 NDARIMIGGKQVSVRIRNIASGTATDYIRSGKYIPDAFTPSNELWGEMVKASGTPAELIT 182 N A I + GK VSV+IRNIASGTATDYI+SGKY+PDAFTPSNELWGEMV+ASG +L+T Sbjct: 121 NKANITVNGKPVSVKIRNIASGTATDYIKSGKYVPDAFTPSNELWGEMVQASGVKTQLVT 180 Query: 183 KRMTGNVAGVVTNKKKYDELVGKYGSLNVKTITDAIAGNELSMGYTDPFASSTGLNFLVT 242 KR+ GNV G+V K KYD ++ KYGS+N++++T+AIA NELSMGYTDPFASSTGLNFLVT Sbjct: 181 KRLVGNVPGIVIAKAKYDAMIDKYGSVNIQSVTEAIANNELSMGYTDPFASSTGLNFLVT 240 Query: 243 ALGTFDSSDLLSDKAVQGFERFQANVPFIASTTLQMRDAAKTGALDAFVLEYQTYVNAPD 302 AL TFDS+DLLSDKAVQ FE+FQ+NVPFIASTT+QMRDAAK+GALD FVLEYQTYVNA D Sbjct: 241 ALHTFDSTDLLSDKAVQEFEKFQSNVPFIASTTIQMRDAAKSGALDGFVLEYQTYVNATD 300 Query: 303 LKSGYVFTPFGVRHDSPLYALGNLPREKEDILHKFAEFAEQDQYQKLAADKGFNGLDDYV 362 LKSGYVFTPFG RHDSPLYALG+LP+EK DIL KFAEF QD+Y K A +KGFNGL+ Y Sbjct: 301 LKSGYVFTPFGFRHDSPLYALGDLPQEKLDILKKFAEFVTQDKYMKTAQEKGFNGLETYK 360 Query: 363 SEAAPVEGTLLTSAQKLWKEKKDGSKPIAAVFVADISGSMAGEPLNHLKESLLKGQKFLG 422 SE APV+G LLTSAQK+WKEKK+G+KPI AVFV D+SGSM GEPLN LKESLLKGQK+LG Sbjct: 361 SELAPVDGDLLTSAQKVWKEKKNGNKPITAVFVTDVSGSMDGEPLNRLKESLLKGQKYLG 420 Query: 423 KDNSIGFVSYSSEVTINLPIAKYDTNQQSMFVGAINSLQAAGGTATFDGMIVAMKMLQDQ 482 +DNSIG VSYS VTI LPIAKYDTNQQS+FVGA+NSLQ+ GGTATFDG++VA+K+L+DQ Sbjct: 421 RDNSIGLVSYSDGVTIKLPIAKYDTNQQSLFVGAVNSLQSGGGTATFDGIVVALKLLEDQ 480 Query: 483 LAANPGVKPLIFVLSDGETNEGHSLDEIRGLIETYKIPVYTIGYNANIKALESISSINEA 542 LA +P KP+IFVLSDGETN+G++L +I+GLIETYKIP+YTIGYNANI+AL++ISSINEA Sbjct: 481 LATDPNTKPVIFVLSDGETNQGYTLQDIKGLIETYKIPIYTIGYNANIQALQNISSINEA 540 Query: 543 ANINADTDDVVYKIGNLLNVQM 564 A+INADTDDVVYKIGNL NVQM Sbjct: 541 ASINADTDDVVYKIGNLFNVQM 562 >B3K3Q6.1 B3K3Q6_9BACI von Willebrand factor type A Length = 562 Score = 871 bits (2251), Expect = 0.0, Method: Compositional matrix adjust. Identities = 417/540 (77%), Positives = 480/540 (88%) Query: 25 YFGITLTSNLGKSDKEISAEDAGRKLNKLYKEIDVTVADTVKGQIDLDPADIGGSLPDIA 84 Y GITLTSNLGKS E+ +E A +K+NK+YK+I VT AD +KGQ+DLDP + SLPDI+ Sbjct: 23 YAGITLTSNLGKSQAEVDSEGAAKKINKIYKDITVTTADPIKGQVDLDPVAVADSLPDIS 82 Query: 85 KFPVSVDNTTDSFVEIFSSTEKSGTGNDGWLNEVAAAFNDARIMIGGKQVSVRIRNIASG 144 KFP+SV+NTTD +VEIFSS EK+G G DGWLNEVA FN ++ ++ GK VSV+IRNIASG Sbjct: 83 KFPISVENTTDLYVEIFSSPEKAGPGIDGWLNEVAEEFNKSKPVVNGKPVSVKIRNIASG 142 Query: 145 TATDYIRSGKYIPDAFTPSNELWGEMVKASGTPAELITKRMTGNVAGVVTNKKKYDELVG 204 TATDYI SGKY+PDAFTPSNELWGEMVK G AEL++KR+TGNV GVVT K KYDELV Sbjct: 143 TATDYITSGKYVPDAFTPSNELWGEMVKEYGVKAELVSKRLTGNVTGVVTRKAKYDELVE 202 Query: 205 KYGSLNVKTITDAIAGNELSMGYTDPFASSTGLNFLVTALGTFDSSDLLSDKAVQGFERF 264 KYGSLNVKT+TDAIA NEL+MGYTDPFASSTGLNFL+TAL TFDS+++L +KAVQGFE+F Sbjct: 203 KYGSLNVKTLTDAIANNELAMGYTDPFASSTGLNFLITALETFDSNNILGEKAVQGFEKF 262 Query: 265 QANVPFIASTTLQMRDAAKTGALDAFVLEYQTYVNAPDLKSGYVFTPFGVRHDSPLYALG 324 QANVPF ASTT+QMRDAAK+G LDAFVLEYQT+VNA D+KSGYVFTPFGVRHDSPLYALG Sbjct: 263 QANVPFTASTTIQMRDAAKSGMLDAFVLEYQTFVNAADMKSGYVFTPFGVRHDSPLYALG 322 Query: 325 NLPREKEDILHKFAEFAEQDQYQKLAADKGFNGLDDYVSEAAPVEGTLLTSAQKLWKEKK 384 LP+EK DI+ KFAEF EQD+YQ++A KGFNGL+DY SE V+ +LL SAQKLWKEKK Sbjct: 323 KLPKEKLDIIKKFAEFVEQDKYQQMADKKGFNGLNDYQSELEVVDSSLLPSAQKLWKEKK 382 Query: 385 DGSKPIAAVFVADISGSMAGEPLNHLKESLLKGQKFLGKDNSIGFVSYSSEVTINLPIAK 444 DG+KP+AAVFVAD+SGSM GEPLN LKESLL GQK+LG+DNSIGFVSYS++VTINLPI K Sbjct: 383 DGNKPVAAVFVADVSGSMDGEPLNRLKESLLTGQKYLGRDNSIGFVSYSTDVTINLPIGK 442 Query: 445 YDTNQQSMFVGAINSLQAAGGTATFDGMIVAMKMLQDQLAANPGVKPLIFVLSDGETNEG 504 YD NQQSMFVGAINSL+A+G TATFDG++VAMKMLQD++AANP VKPLIFVLSDGETN G Sbjct: 443 YDLNQQSMFVGAINSLEASGNTATFDGIVVAMKMLQDEMAANPDVKPLIFVLSDGETNVG 502 Query: 505 HSLDEIRGLIETYKIPVYTIGYNANIKALESISSINEAANINADTDDVVYKIGNLLNVQM 564 HSLD+IRGLI+ +KIPVYTIGYNA+I+AL+SISSINEAA+INADTDDVVYKIG LLNVQM Sbjct: 503 HSLDDIRGLIQAFKIPVYTIGYNADIQALQSISSINEAASINADTDDVVYKIGQLLNVQM 562 >A3DK47.1 A3DK47_CLOTH von Willebrand factor, type A Length = 565 Score = 743 bits (1917), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/554 (63%), Positives = 446/554 (80%) Query: 11 IILVVIAASVFALIYFGITLTSNLGKSDKEISAEDAGRKLNKLYKEIDVTVADTVKGQID 70 +IL+ IA VF LIY GI+LT N GKS K IS E A +KL+KLYK+I V + + KGQ+D Sbjct: 12 VILLGIALVVFGLIYGGISLTQNFGKSQKVISMESAEKKLDKLYKDITVNIIEPKKGQVD 71 Query: 71 LDPADIGGSLPDIAKFPVSVDNTTDSFVEIFSSTEKSGTGNDGWLNEVAAAFNDARIMIG 130 +DP D+ SLPDI+K+P V+ TT +F+EIFSSTEKSG DGWL +VA FN A I + Sbjct: 72 IDPPDLKESLPDISKYPPQVEETTGTFIEIFSSTEKSGEKKDGWLLDVAREFNRANIQVN 131 Query: 131 GKQVSVRIRNIASGTATDYIRSGKYIPDAFTPSNELWGEMVKASGTPAELITKRMTGNVA 190 GK VSVRIR IASG ATDYI SGKY+PDAFTPSNELWGEM++ASG L+ KR+ GNVA Sbjct: 132 GKPVSVRIRGIASGLATDYIISGKYLPDAFTPSNELWGEMIRASGVDISLVEKRLAGNVA 191 Query: 191 GVVTNKKKYDELVGKYGSLNVKTITDAIAGNELSMGYTDPFASSTGLNFLVTALGTFDSS 250 GV+ +K KY+EL+ KYGS+N+K IT+A+A NE++MGYT+PFASSTG+NFLV+ L TFDS Sbjct: 192 GVLLSKAKYEELLQKYGSINLKNITEAVAANEIAMGYTNPFASSTGMNFLVSTLSTFDSK 251 Query: 251 DLLSDKAVQGFERFQANVPFIASTTLQMRDAAKTGALDAFVLEYQTYVNAPDLKSGYVFT 310 ++LS+KA++GFE+FQ N+PF+A TTLQMR++AK+G LD F+LEYQTY N P+LK YVFT Sbjct: 252 NILSEKAIEGFEKFQTNIPFVAYTTLQMRESAKSGVLDGFILEYQTYENTPELKKDYVFT 311 Query: 311 PFGVRHDSPLYALGNLPREKEDILHKFAEFAEQDQYQKLAADKGFNGLDDYVSEAAPVEG 370 PFGVRHDSP+YA+GNL +EK++IL+KF EF + + Q+LA + GFN LDDY+ E + +G Sbjct: 312 PFGVRHDSPMYAIGNLTQEKKEILNKFVEFCKSSKSQELATEYGFNRLDDYLPEISNFDG 371 Query: 371 TLLTSAQKLWKEKKDGSKPIAAVFVADISGSMAGEPLNHLKESLLKGQKFLGKDNSIGFV 430 + AQKLWKEKKD + I AVFVAD+SGSMAGEPLN LK+SL+ G K++ D SIG V Sbjct: 372 EAIMKAQKLWKEKKDVNNDIVAVFVADVSGSMAGEPLNRLKQSLINGSKYISSDVSIGLV 431 Query: 431 SYSSEVTINLPIAKYDTNQQSMFVGAINSLQAAGGTATFDGMIVAMKMLQDQLAANPGVK 490 SYS++V INLPIAK+D NQ+S+FVGA+ SL A G TATFD +IVA KML+++ A NP K Sbjct: 432 SYSTDVNINLPIAKFDLNQRSLFVGAVESLAAGGNTATFDAIIVATKMLKEEKAKNPNAK 491 Query: 491 PLIFVLSDGETNEGHSLDEIRGLIETYKIPVYTIGYNANIKALESISSINEAANINADTD 550 ++FVLSDG TN GHSL++I+ +++T+ IP+YTIGYNANIKALE++S INEAANINADT+ Sbjct: 492 LMLFVLSDGVTNYGHSLNDIKDMMKTFGIPIYTIGYNANIKALETLSQINEAANINADTE 551 Query: 551 DVVYKIGNLLNVQM 564 DVVY++G+L N QM Sbjct: 552 DVVYQLGSLFNAQM 565 >B4BD57.1 B4BD57_CLOTM von Willebrand factor type A Length = 565 Score = 743 bits (1917), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/554 (63%), Positives = 446/554 (80%) Query: 11 IILVVIAASVFALIYFGITLTSNLGKSDKEISAEDAGRKLNKLYKEIDVTVADTVKGQID 70 +IL+ IA VF LIY GI+LT N GKS K IS E A +KL+KLYK+I V + + KGQ+D Sbjct: 12 VILLGIALVVFGLIYGGISLTQNFGKSQKVISMESAEKKLDKLYKDITVNIIEPKKGQVD 71 Query: 71 LDPADIGGSLPDIAKFPVSVDNTTDSFVEIFSSTEKSGTGNDGWLNEVAAAFNDARIMIG 130 +DP D+ SLPDI+K+P V+ TT +F+EIFSSTEKSG DGWL +VA FN A I + Sbjct: 72 IDPPDLKESLPDISKYPPQVEETTGTFIEIFSSTEKSGEKKDGWLLDVAREFNRANIQVN 131 Query: 131 GKQVSVRIRNIASGTATDYIRSGKYIPDAFTPSNELWGEMVKASGTPAELITKRMTGNVA 190 GK VSVRIR IASG ATDYI SGKY+PDAFTPSNELWGEM++ASG L+ KR+ GNVA Sbjct: 132 GKPVSVRIRGIASGLATDYIISGKYLPDAFTPSNELWGEMIRASGVDISLVEKRLAGNVA 191 Query: 191 GVVTNKKKYDELVGKYGSLNVKTITDAIAGNELSMGYTDPFASSTGLNFLVTALGTFDSS 250 GV+ +K KY+EL+ KYGS+N+K IT+A+A NE++MGYT+PFASSTG+NFLV+ L TFDS Sbjct: 192 GVLLSKAKYEELLQKYGSINLKNITEAVAANEIAMGYTNPFASSTGMNFLVSTLSTFDSK 251 Query: 251 DLLSDKAVQGFERFQANVPFIASTTLQMRDAAKTGALDAFVLEYQTYVNAPDLKSGYVFT 310 ++LS+KA++GFE+FQ N+PF+A TTLQMR++AK+G LD F+LEYQTY N P+LK YVFT Sbjct: 252 NILSEKAIEGFEKFQTNIPFVAYTTLQMRESAKSGVLDGFILEYQTYENTPELKKDYVFT 311 Query: 311 PFGVRHDSPLYALGNLPREKEDILHKFAEFAEQDQYQKLAADKGFNGLDDYVSEAAPVEG 370 PFGVRHDSP+YA+GNL +EK++IL+KF EF + + Q+LA + GFN LDDY+ E + +G Sbjct: 312 PFGVRHDSPMYAIGNLTQEKKEILNKFVEFCKSSKSQELATEYGFNRLDDYLPEISNFDG 371 Query: 371 TLLTSAQKLWKEKKDGSKPIAAVFVADISGSMAGEPLNHLKESLLKGQKFLGKDNSIGFV 430 + AQKLWKEKKD + I AVFVAD+SGSMAGEPLN LK+SL+ G K++ D SIG V Sbjct: 372 EAIMKAQKLWKEKKDVNNDIVAVFVADVSGSMAGEPLNRLKQSLINGSKYISSDVSIGLV 431 Query: 431 SYSSEVTINLPIAKYDTNQQSMFVGAINSLQAAGGTATFDGMIVAMKMLQDQLAANPGVK 490 SYS++V INLPIAK+D NQ+S+FVGA+ SL A G TATFD +IVA KML+++ A NP K Sbjct: 432 SYSTDVNINLPIAKFDLNQRSLFVGAVESLAAGGNTATFDAIIVATKMLKEEKAKNPNAK 491 Query: 491 PLIFVLSDGETNEGHSLDEIRGLIETYKIPVYTIGYNANIKALESISSINEAANINADTD 550 ++FVLSDG TN GHSL++I+ +++T+ IP+YTIGYNANIKALE++S INEAANINADT+ Sbjct: 492 LMLFVLSDGVTNYGHSLNDIKDMMKTFGIPIYTIGYNANIKALETLSQINEAANINADTE 551 Query: 551 DVVYKIGNLLNVQM 564 DVVY++G+L N QM Sbjct: 552 DVVYQLGSLFNAQM 565 >Q8TN39.1 Q8TN39_METAC Putative uncharacterized protein Length = 551 Score = 679 bits (1752), Expect = 0.0, Method: Compositional matrix adjust. Identities = 331/567 (58%), Positives = 431/567 (76%), Gaps = 21/567 (3%) Query: 3 MAEKGKKGIILVVIAASV--FALIYFGITLTSNLGKSDKEISAEDAGRKLNKLYKEIDVT 60 M + +IL +I A+V F L+Y IT+ +G S+ L+ + ++I+V Sbjct: 1 MLNESNNKVILKIIGAAVVVFVLVYLAITI---IGPSEG---------SLDDIIEDINVN 48 Query: 61 VADTVKGQIDLDPA---DIGGSLPDIAKFPVSVDNTTDSFVEIFSSTEKSGTGNDGWLNE 117 G + + P + +LP+I+ +P V+N+T +++EIFSSTEK+G+G DGWL E Sbjct: 49 TVSHPMGHVVISPNLDDSLTENLPEISNYPPQVNNSTPTYIEIFSSTEKAGSGADGWLTE 108 Query: 118 VAAAFNDARIMIGGKQVSVRIRNIASGTATDYIRSGKYIPDAFTPSNELWGEMVKASGTP 177 VA FN A I I GKQVSVR+R I SG A DYI SGKY+PDA+TPSNELWGEM+ + G Sbjct: 109 VARDFNSAAITIDGKQVSVRLRGIPSGEAADYITSGKYLPDAYTPSNELWGEMIISKGVK 168 Query: 178 AELITKRMTGNVAGVVTNKKKYDELVGKYGSLNVKTITDAIAGNELSMGYTDPFASSTGL 237 AEL+ +R+ GNVAG++ K K DELV K+G +N KTITDA+A EL+MGYT+PFASSTGL Sbjct: 169 AELVQERLVGNVAGILLTKSKKDELVDKHGEINTKTITDAVANKELAMGYTNPFASSTGL 228 Query: 238 NFLVTALGTFDSSDLLSDKAVQGFERFQANVPFIASTTLQMRDAAKTGALDAFVLEYQTY 297 NFL+++L TFDSS+LLSDKA GFE FQ N+P +A TTLQMR++AK+G LD FVLEYQTY Sbjct: 229 NFLISSLYTFDSSNLLSDKAKSGFESFQINIPLVAYTTLQMRESAKSGVLDGFVLEYQTY 288 Query: 298 VNAPDLKSGYVFTPFGVRHDSPLYALGNLPREKEDILHKFAEFAEQDQYQKLAADKGFNG 357 VN PD++ Y FTPFG RHD+P+YA+G L EK L++F EF++Q++YQ L + GFNG Sbjct: 289 VNTPDIRY-YEFTPFGFRHDNPMYAIGELSGEKRKTLNEFVEFSQQEKYQTLGTEYGFNG 347 Query: 358 LDDYVSEAAPVEGTLLTSAQKLWKEKKDGSKPIAAVFVADISGSMAGEPLNHLKESLLKG 417 ++Y SE PV G ++ AQKLWKEKK KPI AVFVAD+SGSM GEPLN+LK+SLL+G Sbjct: 348 FNEYQSETEPVSGDVIFQAQKLWKEKK---KPICAVFVADVSGSMMGEPLNNLKDSLLRG 404 Query: 418 QKFLGKDNSIGFVSYSSEVTINLPIAKYDTNQQSMFVGAINSLQAAGGTATFDGMIVAMK 477 Q ++G+DN IG VSYS++V I+LPIAK+D NQ++ F GA+N LQA GGTATFDG+ VAMK Sbjct: 405 QYYIGEDNMIGLVSYSNDVNIDLPIAKFDLNQRASFAGAVNDLQAGGGTATFDGIAVAMK 464 Query: 478 MLQDQLAANPGVKPLIFVLSDGETNEGHSLDEIRGLIETYKIPVYTIGYNANIKALESIS 537 M+Q+Q AA+P ++P+IFVLSDGETN+GH L++I+G++E IP+YTIGYNANI AL++IS Sbjct: 465 MIQEQRAADPNIRPVIFVLSDGETNKGHPLNDIKGIVEDTGIPIYTIGYNANIPALQAIS 524 Query: 538 SINEAANINADTDDVVYKIGNLLNVQM 564 SINEAA+INADTDDVVYK+GNL N +M Sbjct: 525 SINEAASINADTDDVVYKLGNLFNAEM 551 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.314 0.133 0.369 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,266,556,544 Number of extensions: 140476137 Number of successful extensions: 290426 Number of sequences better than 1.0e-05: 108 Number of HSP's gapped: 290592 Number of HSP's successfully gapped: 108 Length of query: 564 Length of database: 3,060,696,203 Length adjustment: 141 Effective length of query: 423 Effective length of database: 1,732,333,088 Effective search space: 732776896224 Effective search space used: 732776896224 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 134 (56.2 bits)