BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0510.0006.p (466 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3K5C2.1 B3K5C2_9BACI Xanthine/uracil/vitamin C permease 435 e-120 A4J729.1 A4J729_DESRM Xanthine/uracil/vitamin C permease 404 e-111 A1HSV8.1 A1HSV8_9FIRM Xanthine/uracil/vitamin C permease 400 e-109 B0TED4.1 B0TED4_HELMI Xanthine/uracil permease family protein, p... 399 e-109 C1TB07.1 C1TB07_9FIRM Permease 372 e-101 >B3K5C2.1 B3K5C2_9BACI Xanthine/uracil/vitamin C permease Length = 456 Score = 435 bits (1119), Expect = e-120, Method: Compositional matrix adjust. Identities = 244/466 (52%), Positives = 310/466 (66%), Gaps = 11/466 (2%) Query: 1 LNRFFKLKENGTTVRTEIMAGLTTFMAMAYILSVNPGTLTAFGRIDMGWYSVFLATALAA 60 + RFFKLKE+GT VRTEI+AGLTTFM MAYIL VN L G + VF ATA+ A Sbjct: 1 MERFFKLKEHGTNVRTEIIAGLTTFMTMAYILLVNNLFLGPDGA-GIPQEGVFFATAVGA 59 Query: 61 GIFTIAMGLFINFPVALAPGMGLNAYFASVVLSSATTDHEFTWQMGLTAVFISGIIFILL 120 G+ T+AMG F+N PVALAPGMGLNAYF +VVLSS + TWQ L AVFISGI+FI+L Sbjct: 60 GLVTMAMGFFVNIPVALAPGMGLNAYFMTVVLSS---NGAITWQAALGAVFISGIVFIIL 116 Query: 121 TITRVRQILLTAIPDSLKHAITVGIGLFITIIGLKNSGLMTIGVEAGKDIAANKFTDVLS 180 T+T+VRQ+LLTA+P++LK AITVGIGLFITI+GLK ++T + G DI+ + Sbjct: 117 TVTKVRQMLLTAVPNNLKIAITVGIGLFITIVGLKLGNIVTASINPGTDISHPVPGGAFN 176 Query: 181 FETVIHMGS-LENTNXXXXXXXXXXXXXXXXXXXRGAILFGILGTTVVAILMGAVDFSTL 239 + +G+ +EN + +GA+L GI+ TT++ I MG D S L Sbjct: 177 ----LGLGNFVENKDTLLAIIGLFLIAILMVLKLKGALLIGIVLTTLIGIPMGVTDLSGL 232 Query: 240 SNPQTPWVPDFSQLNFWEFDWEGIMHTGIVSAIATFTFVELFDTFGTLVGTAERAGIMKN 299 S W+P F L + D +G + G++ I FTFVELFDTFGTLVGTA RAG++KN Sbjct: 233 STAS--WIPSFDNLAVGQMDLKGALGIGLIEVIFIFTFVELFDTFGTLVGTAGRAGLLKN 290 Query: 300 PEEGKKRVGNAMFVDAVAVAGGAMLGTSTTTAYVESAAGVAEGGRTGLTAVTTGVCXXXX 359 EEG+K++G AM VDA V+ GA LGTST TA+VES +GVAEGGRTGLTAVTTGV Sbjct: 291 KEEGEKKLGKAMLVDAGGVSAGAFLGTSTITAFVESTSGVAEGGRTGLTAVTTGVLFILA 350 Query: 360 XXXXXXXXXIPGPATAAALIIVGVLMAQSIRQIDFQDMVLAIPAFLTFAIMPFTYNIANG 419 +P ATA AL+IVGVLM +R I++ D + A PAFLT +MPFT IANG Sbjct: 351 LFLAPIALVVPSAATAPALVIVGVLMMSQVRDIEWDDFMQAFPAFLTIILMPFTGGIANG 410 Query: 420 ISFGIVTYVILACVANLAGKKKYDIHWMMWLLAVLIVLRYVLIGSQ 465 IS GI+ YVILA L G+ +HW+MW+L V+I++RY +G++ Sbjct: 411 ISAGIIAYVILAVFGKLIGRTDTKVHWLMWILFVIILIRYAFLGAE 456 >A4J729.1 A4J729_DESRM Xanthine/uracil/vitamin C permease Length = 457 Score = 404 bits (1039), Expect = e-111, Method: Compositional matrix adjust. Identities = 243/476 (51%), Positives = 304/476 (63%), Gaps = 31/476 (6%) Query: 1 LNRFFKLKENGTTVRTEIMAGLTTFMAMAYILSVNPGTLTAFGRIDMGWYSVFLATALAA 60 L + FKLKEN TTVRTE++AGLTTFM MAYIL +NP L G M +VF ATA+A Sbjct: 2 LEQLFKLKENKTTVRTEVVAGLTTFMTMAYILFLNPNILAGTG---MDKNAVFFATAMAG 58 Query: 61 GIFTIAMGLFINFPVALAPGMGLNAYFASVVLSSATTDHEFTWQMGLTAVFISGIIFILL 120 + TIAMGLF+NFP+ALAPGMGLNAYFA+V A W+ L AVFISGIIF++L Sbjct: 59 AVVTIAMGLFVNFPIALAPGMGLNAYFAAV----AAQGQGMPWETALGAVFISGIIFLIL 114 Query: 121 TITRVRQILLTAIPDSLKHAITVGIGLFITIIGLKNSGLMTIGVEAGKDIAANKFTDVLS 180 T+T++RQIL+ AIP+S+K AITVGIGLFITIIGLK S + V+AG I D L Sbjct: 115 TVTQIRQILMVAIPNSMKRAITVGIGLFITIIGLKLSEVAI--VKAGPVIPPT--MDALQ 170 Query: 181 ---------FETVIHMGSLENTNXXXXXXXXXXXXXXXXXXXRGAILFGILGTTVVAILM 231 FE +GS N + +G++L GI+ TT++ I M Sbjct: 171 KGGVATLKFFEWNSFIGSFHNPSMVLTIIGLIITGILMSRGVKGSLLIGIVLTTIIGIPM 230 Query: 232 GAVDFSTLSNPQTPW-VPDFSQLNFWEFDWEGIMHTGIVSAIATFTFVELFDTFGTLVGT 290 G + + TP+ +PD SQ+ + D G G+ + + TFTFVELFDTFGTLVGT Sbjct: 231 GV---TVIPENFTPFAIPDLSQVYVGKLDIMGAFEMGLWTIVFTFTFVELFDTFGTLVGT 287 Query: 291 AERAGIMKNPEEGKK-RVGNAMFVDAVAVAGGAMLGTSTTTAYVESAAGVAEGGRTGLTA 349 A +AG++ E G+ ++G AM VDA+ V+ GA +GTST TAYVESAAGV EGGRTGLTA Sbjct: 288 AGKAGLLD--ENGQSPKIGKAMLVDALGVSFGAFMGTSTVTAYVESAAGVGEGGRTGLTA 345 Query: 350 VTTGVCXXXXXXXXXXXXXIPGPATAAALIIVGVLMAQSIRQIDFQDMVLAIPAFLTFAI 409 VTTG IP ATA ALIIVG+LM +IR+IDF D PAFLTFA+ Sbjct: 346 VTTGAMFLLALVIAPLAGLIPNAATAPALIIVGLLMVSAIREIDFDDFTEGFPAFLTFAL 405 Query: 410 MPFTYNIANGISFGIVTYVILACVANLAGKKKYDIHWMMWLLAVLIVLRYVLIGSQ 465 MPFTYNIANGI+ GIV Y L +A + ++HWMM+LL V+IV RY+ +G + Sbjct: 406 MPFTYNIANGIAAGIVFYTTL----KVASGRAKEVHWMMYLLFVIIVARYLFLGGE 457 >A1HSV8.1 A1HSV8_9FIRM Xanthine/uracil/vitamin C permease Length = 456 Score = 400 bits (1029), Expect = e-109, Method: Compositional matrix adjust. Identities = 232/468 (49%), Positives = 303/468 (64%), Gaps = 21/468 (4%) Query: 1 LNRFFKLKENGTTVRTEIMAGLTTFMAMAYILSVNPGTLTAFGRIDMGWYSVFLATALAA 60 L + F+L T V+TE+MAG+TTFM MAYIL VNP L A G M +V LATAL A Sbjct: 2 LEKLFELSARKTDVKTEVMAGITTFMTMAYILFVNPSILGAAG---MDKNAVLLATALGA 58 Query: 61 GIFTIAMGLFINFPVALAPGMGLNAYFASVVLSSATTDHEFTWQMGLTAVFISGIIFILL 120 G+ TI MGLF+N+P+ALAPGMGLNA++A V+ +WQ+ L AVFISG+IFILL Sbjct: 59 GLVTIMMGLFVNYPIALAPGMGLNAFYAFTVV----IGMGVSWQVALGAVFISGLIFILL 114 Query: 121 TITRVRQILLTAIPDSLKHAITVGIGLFITIIGLKNSGLMTIGVEA-----GKDIAANKF 175 T+T +RQ+L+ +P SLKHAITVGIGLFITIIGLK SG+M+I + K +AA Sbjct: 115 TVTNIRQLLVEGMPTSLKHAITVGIGLFITIIGLKLSGIMSIRLSLIPPTLEKIVAAKGN 174 Query: 176 TDVLSFETVIHMGSLENTNXXXXXXXXXXXXXXXXXXXRGAILFGILGTTVVAILMGAVD 235 + FET+I +G L + + RGA+L GIL TT++ I+MG V Sbjct: 175 GTPMHFETIIELGKLADPHVLLAVFGLVLIAVLMARNVRGAMLIGILTTTIIGIVMGIVK 234 Query: 236 FSTLSNPQTPWVPDFSQLNFWEFDWEGIMHTGIVSAIATFTFVELFDTFGTLVGTAERAG 295 +P VPDFS+ F+ D G +H G+++ I TFTFVELFDT GTLVG A +AG Sbjct: 235 IPAGFSPIA--VPDFSRNAFFALDIWGAIHMGLLTIIFTFTFVELFDTMGTLVGAATKAG 292 Query: 296 IMKNPEEGK-KRVGNAMFVDAVAVAGGAMLGTSTTTAYVESAAGVAEGGRTGLTAVTTGV 354 ++ + GK +G AM VDA V+ GA+LGTST TAYVESAAG+ GGRTGLTA+ G+ Sbjct: 293 LVD--KNGKFPGIGKAMMVDATGVSLGALLGTSTITAYVESAAGIGAGGRTGLTAIVCGI 350 Query: 355 CXXXXXXXXXXXXXIPGPATAAALIIVGVLMAQSIRQIDFQDMVLAIPAFLTFAIMPFTY 414 IP ATA ALIIVG LM +S+R IDF D ++PAF T +MPFTY Sbjct: 351 LFLLALFFTPLAGLIPDAATAPALIIVGALMLESVRHIDFSDFTESMPAFATIVLMPFTY 410 Query: 415 NIANGISFGIVTYVILACVANLAGKKKYDIHWMMWLLAVLIVLRYVLI 462 +IANGIS G+V Y +L V+ + ++HW++++LAVL+VLR++ + Sbjct: 411 SIANGISAGLVLYPVLKLVSG----RGREVHWIVYILAVLVVLRFIFL 454 >B0TED4.1 B0TED4_HELMI Xanthine/uracil permease family protein, putative Length = 454 Score = 399 bits (1024), Expect = e-109, Method: Compositional matrix adjust. Identities = 235/470 (50%), Positives = 297/470 (63%), Gaps = 22/470 (4%) Query: 1 LNRFFKLKENGTTVRTEIMAGLTTFMAMAYILSVNPGTLTAFGRIDMGWYSVFLATALAA 60 L + F LK GT V TEI AG+TTFM MAYIL+VNPG L+A G M +VF AT + A Sbjct: 2 LEKLFHLKAKGTDVATEITAGITTFMTMAYILAVNPGILSATG---MSKDAVFFATCVGA 58 Query: 61 GIFTIAMGLFINFPVALAPGMGLNAYFASVVLSSATTDHEFTWQMGLTAVFISGIIFILL 120 G+ TIAMGL++NFPVALAPGMGLNAYFA V A+ W + L AVFISG+IFI+L Sbjct: 59 GLVTIAMGLYVNFPVALAPGMGLNAYFAVV----ASQRGGIPWDVALGAVFISGLIFIVL 114 Query: 121 TITRVRQILLTAIPDSLKHAITVGIGLFITIIGLKNSGLMTIGVEAGKDIA----ANKFT 176 T+T+VRQ+L+ A+P SLK AIT GIGLFITIIGLK + L + + G + + + Sbjct: 115 TVTQVRQLLIEAVPTSLKKAITAGIGLFITIIGLKLAHLTVVSLHLGPSLGNLTGSGGYG 174 Query: 177 DVLSFETVIHMGSLENTNXXXXXXXXXXXXXXXXXXXRGAILFGILGTTVVAILMGAVDF 236 +L FE + +GS + RGA+L GI+ TT++ + MG Sbjct: 175 QLLYFEWDLIIGSFLKPDTMLALFGLILTAILMAMQVRGALLIGIVTTTLLGVPMGV--- 231 Query: 237 STLSNPQTPWVPDFSQLNFWEFDWEGIMHTGIVSAIATFTFVELFDTFGTLVGTAERAGI 296 + + + W P F+ L + G + G++S + TFTFVELFDTFGTLVGTA RAG+ Sbjct: 232 TKIGDFAFTW-PAFNDLAVGSLNIAGALELGLISVVLTFTFVELFDTFGTLVGTAGRAGL 290 Query: 297 MKNPEEGKK-RVGNAMFVDAVAVAGGAMLGTSTTTAYVESAAGVAEGGRTGLTAVTTGVC 355 + E+G+ ++G AM VDA V+ GA LGTST TAYVESAAG+ EGGRTGLTAVTTG+ Sbjct: 291 LD--EQGRSPQIGKAMLVDAAGVSLGAFLGTSTITAYVESAAGIGEGGRTGLTAVTTGIL 348 Query: 356 XXXXXXXXXXXXXIPGPATAAALIIVGVLMAQSIRQIDFQDMVLAIPAFLTFAIMPFTYN 415 IP ATA ALIIVGVLM +R IDF D A PAFLTF +MPFTYN Sbjct: 349 FLLALVLAPFFRLIPDAATAPALIIVGVLMIGVVRDIDFDDFTDAFPAFLTFTLMPFTYN 408 Query: 416 IANGISFGIVTYVILACVANLAGKKKYDIHWMMWLLAVLIVLRYVLIGSQ 465 IANGI+ GIV Y +L V K +HW+M+LL +L++ RYV +G Sbjct: 409 IANGIAAGIVFYTLLKAVTG----KARQVHWLMYLLTILVIWRYVTLGGH 454 >C1TB07.1 C1TB07_9FIRM Permease Length = 458 Score = 372 bits (956), Expect = e-101, Method: Compositional matrix adjust. Identities = 227/481 (47%), Positives = 304/481 (63%), Gaps = 40/481 (8%) Query: 1 LNRFFKLKENGTTVRTEIMAGLTTFMAMAYILSVNPGTLTAFGRIDMGWYSVFLATALAA 60 L R FKL++ T VRTE++AG TTFM MAYIL +NP L+A G M +VF ATA+AA Sbjct: 2 LERIFKLRQYHTDVRTEVIAGTTTFMTMAYILFLNPNILSATG---MNKDAVFFATAVAA 58 Query: 61 GIFTIAMGLFINFPVALAPGMGLNAYFASVVLSSATTDHEFTWQMGLTAVFISGIIFILL 120 GI TIAMGL +NFP+ALAPGMGLNAYFA+V A WQ L AVFISG+IFI+L Sbjct: 59 GIVTIAMGLIVNFPIALAPGMGLNAYFAAV----AAQGVGIPWQTALGAVFISGLIFIIL 114 Query: 121 TITRVRQILLTAIPDSLKHAITVGIGLFITIIGLKNSGLMTI-----------GVEAGKD 169 T+T++RQ+L+ A+P+SLK AI VGIGLFITI+G+K S +M + G++ Sbjct: 115 TVTKIRQLLVEAVPNSLKRAIIVGIGLFITILGIKMSEIMVVKAGPVIPPTLEGLQKSGG 174 Query: 170 IAANKFTDVLSFETVIHMGSLENTNXXXXXXXXXXXXXXXXXXXRGAILFGILGTTVVAI 229 +A KF FE I MGS N +G++L GIL T++ I Sbjct: 175 VATLKF-----FEWNIFMGSFANPATLLALIGLVITGILMARKVKGSLLLGILAATLIGI 229 Query: 230 LMGAV----DFSTLSNPQTPWVPDFSQLNFWEFDWEGIMHTGIVSAIATFTFVELFDTFG 285 +G +FS S +PDFS L + D +G ++ G+++A+ TFTFVELFDTFG Sbjct: 230 PLGVTVVPPNFSPFS------LPDFSHLAVGKMDIKGALNMGLLTAVFTFTFVELFDTFG 283 Query: 286 TLVGTAERAGIMKNPEEGKK-RVGNAMFVDAVAVAGGAMLGTSTTTAYVESAAGVAEGGR 344 TL+GTA +AG++ E+G+ R+G AM VDA V+ GA++GTST TAY+ES AG+ EGGR Sbjct: 284 TLIGTAGKAGLLD--EKGRSPRIGRAMLVDAFGVSFGALMGTSTVTAYIESTAGIGEGGR 341 Query: 345 TGLTAVTTGVCXXXXXXXXXXXXXIPGPATAAALIIVGVLMAQSIRQIDFQDMVLAIPAF 404 TGLTAVTTG IP ATA LIIVG+LM ++ IDF ++ +PAF Sbjct: 342 TGLTAVTTGALFLLALVLAPIAGLIPSAATAPVLIIVGLLMCSAVAGIDFDNISDGLPAF 401 Query: 405 LTFAIMPFTYNIANGISFGIVTYVILACVANLAGKKKYDIHWMMWLLAVLIVLRYVLIGS 464 LT IMPFTY+IANGI+ GI+ Y +L +A + ++HW+M++L L++ RY+ + Sbjct: 402 LTMVIMPFTYSIANGIAAGIIFYTVL----KVATGRIKEVHWLMYILFFLVIARYLFLAG 457 Query: 465 Q 465 + Sbjct: 458 E 458 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.326 0.139 0.412 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,419,222,465 Number of extensions: 93817438 Number of successful extensions: 381063 Number of sequences better than 1.0e-05: 1992 Number of HSP's gapped: 371812 Number of HSP's successfully gapped: 2261 Length of query: 466 Length of database: 3,060,696,203 Length adjustment: 139 Effective length of query: 327 Effective length of database: 1,751,175,118 Effective search space: 572634263586 Effective search space used: 572634263586 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 133 (55.8 bits)