BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0506.0005.p (470 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3K6T4.1 B3K6T4_9BACI DNA mismatch repair protein MutL 543 e-152 B1DG20.1 B1DG20_9BACL DNA mismatch repair protein MutL 442 e-122 C0ZEZ3.1 C0ZEZ3_BREBN DNA mismatch repair protein MutL 419 e-115 A7GR98.1 MUTL_BACCN DNA mismatch repair protein mutL 404 e-111 C5D9H6.1 C5D9H6_9BACI DNA mismatch repair protein MutL 402 e-110 >B3K6T4.1 B3K6T4_9BACI DNA mismatch repair protein MutL Length = 660 Score = 543 bits (1400), Expect = e-152, Method: Compositional matrix adjust. Identities = 259/350 (74%), Positives = 308/350 (88%), Gaps = 1/350 (0%) Query: 1 VLDEHIANQIAAGEVVERPASVVKELVENAIDAGSTRIEVSVEEGGLQSIRVKDNGSGID 60 +LDEHIANQIAAGEVVERPASVVKELVENAIDAGST+I+VSVEEGGL SIRV DNG+GID Sbjct: 6 ILDEHIANQIAAGEVVERPASVVKELVENAIDAGSTKIDVSVEEGGLDSIRVTDNGAGID 65 Query: 61 PEDCETAFYRHATSKIVNGRDLFQITSLGFRGEALPSIASVSKLSLLTSSNEDGKGRALD 120 PEDCETAFYRHATSKI GRDLFQITSLGFRGEALPSIA+VSK+ L+TS+ +DG+GR ++ Sbjct: 66 PEDCETAFYRHATSKIAEGRDLFQITSLGFRGEALPSIAAVSKVRLVTSNAQDGRGRKIE 125 Query: 121 IEGGKLIRNEDEPAGKGSDLAVRELFYNTPARLKYMKSVQTELGHISDTMYRVALAHPSI 180 IEGG L NE+ A +G+D V+ELFYNTPARLKYMK++QTELGHISD MYR+AL+ P I Sbjct: 126 IEGGHLRVNEETAAPRGTDFLVKELFYNTPARLKYMKTIQTELGHISDYMYRLALSRPDI 185 Query: 181 SFTLHHNGNQLLHTLGNGDLLQVIAAVYGTSAAKAMLPLAAEDPDYRISGYVSRPEWTRS 240 +FTL HNGN LL TLGNGD LQVIAAVYGT +AKAMLP AAE+ DY +SGY+SRP++TR+ Sbjct: 186 AFTLRHNGNSLLQTLGNGDALQVIAAVYGTQSAKAMLPFAAENMDYTLSGYISRPDYTRA 245 Query: 241 NRNAVTTIVGGRYIRSNGLNAAIMRAYHTLLPINRYPLLVLQLEMHPSLVDVNVHPAKLE 300 NRN ++ I+ GRYIR+ GL AI+R YHTLLPINR+PL+V+QL MHPSL+DVNVHP+KLE Sbjct: 246 NRNGMSLIINGRYIRNYGLMQAILRGYHTLLPINRFPLVVIQLSMHPSLIDVNVHPSKLE 305 Query: 301 VRFSKEAELYAFVEQEIRKVLMGQSLIPRPSKEIIGAKGSSSFIQEQFAF 350 VRFSKE EL+AFVE+E+RKVL + LIPRP+K+ IG K ++++IQEQ +F Sbjct: 306 VRFSKEQELFAFVEEEVRKVLQQEILIPRPAKQNIG-KSNNAYIQEQLSF 354 >B1DG20.1 B1DG20_9BACL DNA mismatch repair protein MutL Length = 679 Score = 442 bits (1138), Expect = e-122, Method: Compositional matrix adjust. Identities = 216/352 (61%), Positives = 277/352 (78%), Gaps = 2/352 (0%) Query: 1 VLDEHIANQIAAGEVVERPASVVKELVENAIDAGSTRIEVSVEEGGLQSIRVKDNGSGID 60 VLDE +ANQIAAGEVVERPASV+KELVENAIDAGS+ I++++EEGGL IRV DNG+GI+ Sbjct: 6 VLDEQLANQIAAGEVVERPASVIKELVENAIDAGSSVIDITIEEGGLSFIRVTDNGAGIE 65 Query: 61 PEDCETAFYRHATSKIVNGRDLFQITSLGFRGEALPSIASVSKLSLLTSSNEDGKGRALD 120 P D ETAF RHATSKI + DLF+I SLGFRGEALPSIA+VS+L ++S + G + L Sbjct: 66 PGDMETAFQRHATSKISSSSDLFKIASLGFRGEALPSIAAVSRLECVSSIDSTGLAQRLF 125 Query: 121 IEGGKLIRNEDEPAGKGSDLAVRELFYNTPARLKYMKSVQTELGHISDTMYRVALAHPSI 180 IEGG + +E + +G+D++VR+LFYNTPARLKYMK++QTELGHI+D +YR+ALAHP I Sbjct: 126 IEGGTVTASEPANSPQGTDMSVRDLFYNTPARLKYMKAIQTELGHITDYVYRIALAHPGI 185 Query: 181 SFTLHHNGNQLLHTLGNGDLLQVIAAVYGTSAAKAMLPLAAEDPDYRISGYVSRPEWTRS 240 + TL HNG+ LL TLG GD LQVIAAVYGT+ AKAML + E DY + GY+S+PE TR+ Sbjct: 186 AITLKHNGSVLLRTLGTGDRLQVIAAVYGTNTAKAMLKVEGETSDYDLRGYISKPELTRA 245 Query: 241 NRNAVTTIVGGRYIRSNGLNAAIMRAYHTLLPINRYPLLVLQLEMHPSLVDVNVHPAKLE 300 NRN +T IV GRYIRS+ +N AI++AYHTLLPINR+P++VL++ MHPSL+DVNVHP+K+E Sbjct: 246 NRNGMTVIVNGRYIRSHAVNQAILQAYHTLLPINRFPIVVLEIGMHPSLLDVNVHPSKME 305 Query: 301 VRFSKEAELYAFVEQEIRKVLMGQSLIPRPSKEIIGAKGSSSFIQEQFAFSK 352 VRFSKE EL VEQ ++ L IP P+++ + F+Q+ +F + Sbjct: 306 VRFSKENELRTLVEQAVKGALGQVRHIPGPAEK--PEREKPLFVQDAISFHR 355 >C0ZEZ3.1 C0ZEZ3_BREBN DNA mismatch repair protein MutL Length = 690 Score = 419 bits (1076), Expect = e-115, Method: Compositional matrix adjust. Identities = 211/348 (60%), Positives = 263/348 (75%) Query: 1 VLDEHIANQIAAGEVVERPASVVKELVENAIDAGSTRIEVSVEEGGLQSIRVKDNGSGID 60 VLDE +AN IAAGEVVERPASVVKELVEN+IDA +T IE+ VEEGGL+ IR+ DNG G+D Sbjct: 6 VLDEQLANMIAAGEVVERPASVVKELVENSIDARATTIEIHVEEGGLEMIRIVDNGRGMD 65 Query: 61 PEDCETAFYRHATSKIVNGRDLFQITSLGFRGEALPSIASVSKLSLLTSSNEDGKGRALD 120 EDC+ AF RHATSKI N RDLF+I +LGFRGEALPSIA+VS++ L +S++ G L Sbjct: 66 REDCQLAFERHATSKISNARDLFRIRTLGFRGEALPSIAAVSRMELTSSTSSSEVGTHLL 125 Query: 121 IEGGKLIRNEDEPAGKGSDLAVRELFYNTPARLKYMKSVQTELGHISDTMYRVALAHPSI 180 IEGG+L D+ A KG+++ VR LF+NTPARLKYMKS+ TE+GHISD + R+AL HPSI Sbjct: 126 IEGGQLGTISDKAAVKGTEVCVRSLFFNTPARLKYMKSIATEVGHISDYVNRLALTHPSI 185 Query: 181 SFTLHHNGNQLLHTLGNGDLLQVIAAVYGTSAAKAMLPLAAEDPDYRISGYVSRPEWTRS 240 SF L HNG LL T G+G LL V+AA+YG AK +LP+A E DY+ SG++S+ E TR+ Sbjct: 186 SFLLTHNGKTLLQTSGDGKLLHVMAAIYGVQVAKLLLPIAGETLDYKWSGFLSKTEVTRA 245 Query: 241 NRNAVTTIVGGRYIRSNGLNAAIMRAYHTLLPINRYPLLVLQLEMHPSLVDVNVHPAKLE 300 NR+ ++T+V GRY+RS +N AIMR YHTLLPI RYP++ LQ+EM PSLVDVNVHPAKLE Sbjct: 246 NRSYLSTLVNGRYVRSYSINNAIMRGYHTLLPIGRYPIVALQIEMDPSLVDVNVHPAKLE 305 Query: 301 VRFSKEAELYAFVEQEIRKVLMGQSLIPRPSKEIIGAKGSSSFIQEQF 348 RFSKE EL + +EQ +++ L I RP AK + +Q QF Sbjct: 306 ARFSKEDELCSAIEQSVKETLRQGLGIVRPMVTQPKAKVVTQVVQPQF 353 >A7GR98.1 MUTL_BACCN DNA mismatch repair protein mutL Length = 649 Score = 404 bits (1038), Expect = e-111, Method: Compositional matrix adjust. Identities = 200/349 (57%), Positives = 253/349 (72%), Gaps = 2/349 (0%) Query: 2 LDEHIANQIAAGEVVERPASVVKELVENAIDAGSTRIEVSVEEGGLQSIRVKDNGSGIDP 61 LDE ++N IAAGEVVERPASVVKELVEN+IDA ST IE+ +EE GL IR+ DNG GI Sbjct: 7 LDEQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDNGDGIAE 66 Query: 62 EDCETAFYRHATSKIVNGRDLFQITSLGFRGEALPSIASVSKLSLLTSSNEDGKGRALDI 121 EDC AF RHATSKI + DLF+I +LGFRGEALPSIASVS+L L+TS+ D G L I Sbjct: 67 EDCIVAFERHATSKIKDENDLFRIRTLGFRGEALPSIASVSELELVTSTG-DAPGTHLII 125 Query: 122 EGGKLIRNEDEPAGKGSDLAVRELFYNTPARLKYMKSVQTELGHISDTMYRVALAHPSIS 181 +GG++I+ E + KG+D+ V+ LF+NTPARLKYMK++ TELG+I+D +YR+A++HP +S Sbjct: 126 KGGEIIKQEKTASRKGTDITVQNLFFNTPARLKYMKTIHTELGNITDIVYRIAMSHPEVS 185 Query: 182 FTLHHNGNQLLHTLGNGDLLQVIAAVYGTSAAKAMLPLAAEDPDYRISGYVSRPEWTRSN 241 L HN +LLHT GNGD+ QV+AA+Y AK ++P+ AE D+ I GYV+ PE TR++ Sbjct: 186 LKLFHNTKKLLHTSGNGDVRQVLAAIYSIQVAKKLIPIEAESLDFTIRGYVTLPEVTRAS 245 Query: 242 RNAVTTIVGGRYIRSNGLNAAIMRAYHTLLPINRYPLLVLQLEMHPSLVDVNVHPAKLEV 301 RN ++TIV GRY+R+ L AI + YHTLLP+ RYP+ L +EM P LVDVNVHPAKLEV Sbjct: 246 RNYMSTIVNGRYVRNYVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHPAKLEV 305 Query: 302 RFSKEAELYAFVEQEIRKVLMGQSLIPRPSKEIIGAKGSSSFIQEQFAF 350 RFSKE EL F+EQ ++ LIP K +QEQF F Sbjct: 306 RFSKEQELLQFIEQTLQDAFKKVQLIPDAGV-TTKKKTKDESVQEQFHF 353 >C5D9H6.1 C5D9H6_9BACI DNA mismatch repair protein MutL Length = 619 Score = 402 bits (1032), Expect = e-110, Method: Compositional matrix adjust. Identities = 195/327 (59%), Positives = 250/327 (76%), Gaps = 1/327 (0%) Query: 2 LDEHIANQIAAGEVVERPASVVKELVENAIDAGSTRIEVSVEEGGLQSIRVKDNGSGIDP 61 LD+ ++N+IAAGEVVERPASVVKELVENA+DA ST IE+ +EE GL IRV DNG G++ Sbjct: 7 LDDQLSNKIAAGEVVERPASVVKELVENAVDANSTIIEIELEEAGLTKIRVIDNGDGMEE 66 Query: 62 EDCETAFYRHATSKIVNGRDLFQITSLGFRGEALPSIASVSKLSLLTSSNEDGKGRALDI 121 +DC AF RHATSKI + DLF+I +LGFRGEALPSIASVS++ + TS+ DG G + + Sbjct: 67 DDCLVAFERHATSKIKDEHDLFRIRTLGFRGEALPSIASVSEVEMKTSTG-DGPGTKVVL 125 Query: 122 EGGKLIRNEDEPAGKGSDLAVRELFYNTPARLKYMKSVQTELGHISDTMYRVALAHPSIS 181 +GGKL+ +E + KG+D+ V LF+NTPARLKYMK++ TELGH++D + R+A+AHP IS Sbjct: 126 KGGKLVVHERTTSRKGTDITVSNLFFNTPARLKYMKTIHTELGHVTDVVNRLAMAHPDIS 185 Query: 182 FTLHHNGNQLLHTLGNGDLLQVIAAVYGTSAAKAMLPLAAEDPDYRISGYVSRPEWTRSN 241 F L H+G QLL+T GNGD+ V+AA+YG AK M+P+ AE D+ + GY+S PE TR++ Sbjct: 186 FRLRHHGKQLLYTSGNGDVRHVLAAIYGMDVAKKMIPIQAESLDFTVQGYISLPEVTRAS 245 Query: 242 RNAVTTIVGGRYIRSNGLNAAIMRAYHTLLPINRYPLLVLQLEMHPSLVDVNVHPAKLEV 301 RN ++TIV GRY+R+ L AI YHTLLPI RYP++ L + M P LVDVNVHPAKLEV Sbjct: 246 RNYISTIVNGRYVRNIPLAKAIEAGYHTLLPIGRYPIVFLSIAMDPILVDVNVHPAKLEV 305 Query: 302 RFSKEAELYAFVEQEIRKVLMGQSLIP 328 RFSKEAEL V Q IR+ L ++LIP Sbjct: 306 RFSKEAELNELVTQAIRQALQARTLIP 332 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.318 0.134 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,612,296,996 Number of extensions: 105338866 Number of successful extensions: 301094 Number of sequences better than 1.0e-05: 1842 Number of HSP's gapped: 298251 Number of HSP's successfully gapped: 1846 Length of query: 470 Length of database: 3,060,696,203 Length adjustment: 139 Effective length of query: 331 Effective length of database: 1,751,175,118 Effective search space: 579638964058 Effective search space used: 579638964058 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 133 (55.8 bits)