BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0500.0011.p (461 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value A3IYS8.1 A3IYS8_9CHRO Coproporphyrinogen III oxidase 389 e-106 B9XL16.1 B9XL16_9BACT Coproporphyrinogen dehydrogenase EC=1.3.99.22 357 1e-96 Q1D8C4.1 Q1D8C4_MYXXD Coproporphyrinogen III oxidase family protein 354 1e-95 A9B7V6.1 A9B7V6_HERA2 Coproporphyrinogen dehydrogenase EC=1.3.99.22 330 3e-88 A8CY29.1 A8CY29_9CHLR Radical SAM domain protein 323 2e-86 >A3IYS8.1 A3IYS8_9CHRO Coproporphyrinogen III oxidase Length = 447 Score = 389 bits (998), Expect = e-106, Method: Compositional matrix adjust. Identities = 195/435 (44%), Positives = 265/435 (60%), Gaps = 4/435 (0%) Query: 28 EHITADPYRNYLYSYPHKTAYRDLNPPVPLEPLWREEPAESFFLYMHIPFCGARCGFCNL 87 E + A PY+ Y+YSYPHKTAYR LNPP+ L +W E + FLY+HIPFC RCGFCNL Sbjct: 14 ELLAASPYQTYVYSYPHKTAYRPLNPPIQLSDVWSRENRNALFLYIHIPFCEMRCGFCNL 73 Query: 88 FTLPDKRAEVHTVYVDALERQARQWAAFTGGKPFARFAIGGGTPSLLAPAQLRRLFRIAE 147 FT+ K + + YV L+RQ+ + G FARFA+GGGTP+ L L+ + IAE Sbjct: 74 FTMVQKDEDFVSQYVATLKRQSERVKQALGESKFARFALGGGTPTRLPFQALKAVLDIAE 133 Query: 148 DIMGLDPASASISVETSPETLTEDKLNILKEHTVDRVSMGIQSFVAAESAAIYRPQNPDE 207 + MG + + SVE SPET T+DKLN+L++ +DR+S+G+QSFV E AI R Q + Sbjct: 134 NTMGANLQAIPCSVEVSPETATQDKLNLLRDRGIDRISIGVQSFVDTEVLAIQRRQEATQ 193 Query: 208 VYRALELLKLYDFPVLNLDLIYGLPGQTVDSWLYSLEQAVNHEPEEIFIYPLYTRDHTIV 267 V L +K +FP LN+DLIYGLPGQT+D+WLYSL+QA+ +PEEI++YPLY R T + Sbjct: 194 VKEVLTSIKDKNFPTLNIDLIYGLPGQTIDTWLYSLQQAIAFQPEEIYLYPLYVRPLTGM 253 Query: 268 KPEDIRRQTDIRHECYRAAQQLLAEHGYTQYSMRRFARATAGTHKSIIDYSCQEEGMVGL 327 + + DIR CYR + L +GY Q SMR F + + + + Y CQ +GMVGL Sbjct: 254 DCTN-KEWDDIRLNCYRQGRDFLLANGYQQISMRMFQKPSNSNISAPV-YCCQADGMVGL 311 Query: 328 GCGARSYTRNVHYASRYGVSRKATESIIADYV--AAERYDTADYGIVLSLEEQKRRYILK 385 GCGARSYT+ +HYAS Y V K +SI+ Y+ E +D +YG L E+++RRYIL Sbjct: 312 GCGARSYTKQLHYASEYAVGAKGIQSILQAYLDTPTESFDYINYGFTLDTEDRQRRYILI 371 Query: 386 AVLHSEGLKLADYSGRFGSSLWRDHPXXXXXXXXXXXXXXXXXXXXXXXXXXYSDSIGDW 445 ++L +EGL + Y FG+ L D+P SD+IG W Sbjct: 372 SLLSNEGLNIKQYHHIFGTELLIDYPELTELLERNLAIKDRDTISLTELGIERSDTIGYW 431 Query: 446 FISGEIREQMERFVL 460 F S ++R+ M + L Sbjct: 432 FFSNKVRKLMTEYEL 446 >B9XL16.1 B9XL16_9BACT Coproporphyrinogen dehydrogenase EC=1.3.99.22 Length = 444 Score = 357 bits (916), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 190/423 (44%), Positives = 249/423 (58%), Gaps = 4/423 (0%) Query: 35 YRNYLYSYPHKTAYRDLNPPVPLEPLWREEPAESFFLYMHIPFCGARCGFCNLFTLPDKR 94 Y Y Y+YPHKTAYR L +PL LW + + FLY+H+PFC RCGFCNLFT + Sbjct: 18 YEAYTYAYPHKTAYRSLAEQIPLRTLWETQQCNALFLYVHVPFCEMRCGFCNLFTTTNPN 77 Query: 95 AEVHTVYVDALERQARQWAAFTGGKPFARFAIGGGTPSLLAPAQLRRLFRIAEDIMGLDP 154 + Y+ AL+RQA FAR A GGGTP+ L PA+L LF + E+IMG D Sbjct: 78 QTLIDGYLAALQRQASVVRDALHNPAFARLAFGGGTPTFLEPAELEILFAVVEEIMGADS 137 Query: 155 ASASISVETSPETLTEDKLNILKEHTVDRVSMGIQSFVAAESAAIYRPQNPDEVYRALEL 214 S SVETSP T T ++LN+L +H VDR+S+GIQSF+ E AA+ R Q EV AL+ Sbjct: 138 RSLPFSVETSPATATCERLNLLHDHGVDRISIGIQSFLEHEVAAVGRSQKRQEVETALQN 197 Query: 215 LKLYDFPVLNLDLIYGLPGQTVDSWLYSLEQAVNHEPEEIFIYPLYTRDHTIVKPEDIRR 274 ++ +FP LN+DLIYGLPGQT+DSW+ SL A+ + PEE+F+YPLY R T + +D R Sbjct: 198 IRSLNFPTLNIDLIYGLPGQTMDSWMESLSSALQYRPEELFLYPLYVRPLTGLGRKD-RH 256 Query: 275 QTDIRHECYRAAQQLLAEHGYTQYSMRRFARATAGTHKSIIDYSCQEEGMVGLGCGARSY 334 D+R + YR A+ L +GYTQ SMR F A T + Y QE+GM+GLGCGARSY Sbjct: 257 WEDLRLQMYREARSRLLANGYTQISMRMFRAEHAPTAEGPA-YCAQEDGMIGLGCGARSY 315 Query: 335 TRNVHYASRYGVSRKATESIIADY--VAAERYDTADYGIVLSLEEQKRRYILKAVLHSEG 392 TRN+HYA Y V ++I + +++ ADYG +L EQKRRY+ + +L + G Sbjct: 316 TRNLHYAMPYAVDSINVRNLIQSFNQTTEDQFAHADYGFILDDSEQKRRYVAQTLLLASG 375 Query: 393 LKLADYSGRFGSSLWRDHPXXXXXXXXXXXXXXXXXXXXXXXXXXYSDSIGDWFISGEIR 452 L L Y RFG+S++ D P SD IG W S ++ Sbjct: 376 LPLDFYQKRFGTSVFEDLPELCELEVLGFAVRESQLLRLTTEGMERSDVIGPWLYSPQVV 435 Query: 453 EQM 455 E M Sbjct: 436 ELM 438 >Q1D8C4.1 Q1D8C4_MYXXD Coproporphyrinogen III oxidase family protein Length = 438 Score = 354 bits (908), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 193/440 (43%), Positives = 254/440 (57%), Gaps = 9/440 (2%) Query: 23 VTQWREHITADPYRNYLYSYPHKTAYRDLNPPVPLEPLWREEPAESFFLYMHIPFCGARC 82 +T+ + + PY YLY YPHKTAYR P +PLE +W EE ++ FLY+H+PFC RC Sbjct: 1 MTRLEQMLEGSPYVAYLYGYPHKTAYRPFTPALPLESVWAEERRDALFLYIHVPFCEMRC 60 Query: 83 GFCNLFTLPDKRAEVHTVYVDALERQARQWAAFTGGKPFARFAIGGGTPSLLAPAQLRRL 142 GFCNLFT + +V Y+ AL R+ ++ G FAR AIGGGTP+LL A L + Sbjct: 61 GFCNLFTAAGPKQDVVDGYLGALVRETKRVKEALGTASFARAAIGGGTPTLLDVAGLNTV 120 Query: 143 FRIAEDIMGLDPASASISVETSPETLTEDKLNILKEHTVDRVSMGIQSFVAAESAAIYRP 202 F +AE +MG D + +SVE SPET+ KL +L+ DRVSMGIQSF+ AE AA+ RP Sbjct: 121 FDMAEGVMGADMKNIPVSVEVSPETVDAQKLQVLRSRGTDRVSMGIQSFIEAEVAAVKRP 180 Query: 203 QNPDEVYRALELLKLYDFPVLNLDLIYGLPGQTVDSWLYSLEQAVNHEPEEIFIYPLYTR 262 Q +V AL+L++ FP LNLDLIYG+ GQT +S+LYSL A+ + PEEI++YPLY R Sbjct: 181 QKTAQVEAALDLIRSTGFPTLNLDLIYGMEGQTEESFLYSLRTALRYSPEEIYLYPLYVR 240 Query: 263 DHTIVKPEDIRRQTDIRHECYRAAQQLLAEHGYTQYSMRRFARATAGTHKSIIDYSCQEE 322 T + + R D+R YR + L GYTQ SMR F RA Y CQE+ Sbjct: 241 PLTFLG-KKARAWDDLRLSLYRVGRDFLLSEGYTQVSMRMF-RARHAPDAGGPVYRCQED 298 Query: 323 GMVGLGCGARSYTRNVHYASRYGVSRKATESIIADYVAAER----YDTADYGIVLSLEEQ 378 GMVGLGCGARSYT VHY+S Y V + SII+ Y +ER + YG L E+ Sbjct: 299 GMVGLGCGARSYTGQVHYSSEYAVGSREVRSIISSY--SERSEASFGEVGYGFRLDSAER 356 Query: 379 KRRYILKAVLHSEGLKLADYSGRFGSSLWRDHPXXXXXXXXXXXXXXXXXXXXXXXXXXY 438 +RRY+L ++L ++G+ LA Y RF S D P Sbjct: 357 RRRYMLLSLL-ADGVDLAVYRQRFCSDALEDFPELEELEAHGLARKNGGVVQLTAAGVER 415 Query: 439 SDSIGDWFISGEIREQMERF 458 SD IG W S +++ M+ + Sbjct: 416 SDMIGPWLHSDQVQAMMKEY 435 >A9B7V6.1 A9B7V6_HERA2 Coproporphyrinogen dehydrogenase EC=1.3.99.22 Length = 439 Score = 330 bits (845), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 179/436 (41%), Positives = 244/436 (55%), Gaps = 3/436 (0%) Query: 27 REHITADPYRNYLYSYPHKTAYRDLNPPVPLEPLWREEPAESFFLYMHIPFCGARCGFCN 86 RE+ A PY Y YSYPHK+AYR L P L +W +E + FLY+HIPFC RCGFCN Sbjct: 4 REYANATPYMGYSYSYPHKSAYRQLEPR-SLREVWADEAHDQLFLYLHIPFCEMRCGFCN 62 Query: 87 LFTLPDKRAEVHTVYVDALERQARQWAAFTGGKPFARFAIGGGTPSLLAPAQLRRLFRIA 146 LFT + V Y+ LE Q + G F+R AIGGGTP+ L+ ++L +LF ++ Sbjct: 63 LFTTTNPNESVVQRYLATLELQMQALHNELGAVQFSRMAIGGGTPTYLSASELEQLFSMS 122 Query: 147 EDIMGLDPASASISVETSPETLTEDKLNILKEHTVDRVSMGIQSFVAAESAAIYRPQNPD 206 + +G++ + +SVETSP T T D++ IL + VDRVS+G+QSF+ E+ A R Q Sbjct: 123 QRWLGVNSRAIPLSVETSPHTATADRMAILAQAGVDRVSIGVQSFLDHEAHAAGRAQRRP 182 Query: 207 EVYRALELLKLYDFPVLNLDLIYGLPGQTVDSWLYSLEQAVNHEPEEIFIYPLYTRDHTI 266 EV +AL ++ P LN+DLIYGLP Q+V +WL SLE + PEE+++YPLY R T Sbjct: 183 EVEQALATVRAAQIPTLNIDLIYGLPNQSVATWLESLEIGLQWRPEELYLYPLYVRPLTG 242 Query: 267 VKPEDIRRQTDIRHECYRAAQQLLAEHGYTQYSMRRFARATAGTHKSIIDYSCQEEGMVG 326 + + D+R ECYRA ++ L GY Q SMR F A A Y CQ +GM+G Sbjct: 243 LDRRGTGWEHDLRLECYRAGRERLLAAGYQQISMRMFRAAHAPDDSQAPRYCCQTDGMLG 302 Query: 327 LGCGARSYTRNVHYASRYGVSRKATESIIADYVAAERYDTA--DYGIVLSLEEQKRRYIL 384 LG GARSYTR +HY+S Y V + II +Y D + DYG V+S EQ+RR+++ Sbjct: 303 LGAGARSYTRKLHYSSDYAVGASSVRQIIQNYNQRSLLDLSQVDYGCVVSSTEQRRRFVI 362 Query: 385 KAVLHSEGLKLADYSGRFGSSLWRDHPXXXXXXXXXXXXXXXXXXXXXXXXXXYSDSIGD 444 +++L GL Y +FGS + D SD IG Sbjct: 363 QSLLQVSGLDTQAYRAQFGSDVLADLSQINELIEIGWAEYQHGIYQLTPAGLERSDLIGP 422 Query: 445 WFISGEIREQMERFVL 460 W S +IR+ F+L Sbjct: 423 WLYSPQIRQLSAEFIL 438 >A8CY29.1 A8CY29_9CHLR Radical SAM domain protein Length = 698 Score = 323 bits (829), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 182/438 (41%), Positives = 240/438 (54%), Gaps = 12/438 (2%) Query: 34 PYRNYLYSYPHKTAYRDLNPPVPLEPLWREEPAESFFLYMHIPFCGARCGFCNLFTLPDK 93 PY+ Y YSYPHKTAYR L PP L LW EP +S FLY+H+PFC RCGFCNLF L Sbjct: 261 PYQAYSYSYPHKTAYRPLQPPRALRELWAGEPRDSLFLYLHVPFCSYRCGFCNLFALARP 320 Query: 94 RAEVHTVYVDALERQARQWAAFTGGKPFARFAIGGGTPSLLAPAQLRRLFRIAEDIMGLD 153 Y+ +E+Q R G F RFAIGGGTPS L AQLRRLF + E +D Sbjct: 321 EPAKVERYLAQMEQQLRATCEALGEHRFVRFAIGGGTPSYLDAAQLRRLFDMVERHARID 380 Query: 154 PASASISVETSPETLTEDKLNILKEHTVDRVSMGIQSFVAAESAAIYRPQNPDEVYRALE 213 + +E SPET+ +K+ + +E +DRVSMGIQSF AE A+ RPQ V +A+ Sbjct: 381 LRAIPAGIEVSPETVDAEKMALCRERGIDRVSMGIQSFSEAEVRALVRPQQRAVVEQAIA 440 Query: 214 LLKLYDFPVLNLDLIYGLPGQTVDSWLYSLEQAVNHEPEEIFIYPLYTRDHTIVKPEDIR 273 ++ LNLDLIYG+ GQTV S+L S++ A+ H +E+++YPLY R T + + + Sbjct: 441 TIRAAGIATLNLDLIYGIAGQTVASFLASIDSALEHRAQELYLYPLYVRPLTGLGRIEAK 500 Query: 274 RQT---------DIRHECYRAAQQLLAEHGYTQYSMRRFARATAGTHKSIIDYSCQEEGM 324 T D R Y A + L GY Q SMR F RA + Y CQ +GM Sbjct: 501 AGTRLPLQAEPMDERLALYEAGRDRLLAAGYEQVSMRMF-RAPHAPDIAAPVYCCQSDGM 559 Query: 325 VGLGCGARSYTRNVHYASRYGVSRKATESIIADYVA--AERYDTADYGIVLSLEEQKRRY 382 VG+GCGARSYT +HY+S YGV+R++ I+ Y+ A + ADYGI L EE++RR+ Sbjct: 560 VGIGCGARSYTSTLHYSSEYGVARRSVAEILDHYLERDAASFAAADYGIALGEEERRRRH 619 Query: 383 ILKAVLHSEGLKLADYSGRFGSSLWRDHPXXXXXXXXXXXXXXXXXXXXXXXXXXYSDSI 442 ++++L GL ADY RFG+ P +D+I Sbjct: 620 AIQSLLIRPGLDRADYRRRFGADCLEQLPQLRELFEHALAVENGELIELTDAGLARADTI 679 Query: 443 GDWFISGEIREQMERFVL 460 G W S I E+M + L Sbjct: 680 GPWLASAAIVERMRDYRL 697 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.321 0.137 0.420 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,749,176,639 Number of extensions: 113951870 Number of successful extensions: 256824 Number of sequences better than 1.0e-05: 2622 Number of HSP's gapped: 250822 Number of HSP's successfully gapped: 2622 Length of query: 461 Length of database: 3,060,696,203 Length adjustment: 139 Effective length of query: 322 Effective length of database: 1,751,175,118 Effective search space: 563878387996 Effective search space used: 563878387996 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 133 (55.8 bits)