BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0489.0025.p (1943 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Q2XP40.1 Q2XP40_BACSU SubA 1272 0.0 O68006.1 BACA_BACLI Bacitracin synthetase 1 ATP-dependent isoleu... 1270 0.0 C3IK59.1 C3IK59_BACTU AMP-binding enzyme 1269 0.0 B7IJF1.1 B7IJF1_BACC2 Bacitracin synthetase 1 EC=5.1.1.3 1264 0.0 C3DKL0.1 C3DKL0_BACTS AMP-binding enzyme 1264 0.0 >Q2XP40.1 Q2XP40_BACSU SubA Length = 5254 Score = 1272 bits (3291), Expect = 0.0, Method: Compositional matrix adjust. Identities = 686/1709 (40%), Positives = 1013/1709 (59%), Gaps = 49/1709 (2%) Query: 248 VLKHPAQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVTFR 307 V KH + G+ H E + +L+ FN T +YP++ T+H+LF + + P A+ F Sbjct: 2 VAKHSLE-NGVFHKMTENEKELILH-FNNTKTDYPKNKTLHELFEEQAMKTPDHTALVFG 59 Query: 308 NQSITYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPIDP 367 Q +TY ELN GIG I A+I RS +M PIDP Sbjct: 60 AQRMTYRELNEKANQTARLLREKGIGRGSIAAIIADRSFEMIIGIIGILKAGGAYLPIDP 119 Query: 368 GLPANRIAYMLDDAGVQVILTN----TSVENQGNRIVLDMRSLGLDHGAPLPVPPVHSSR 423 P +RIA+ML D V+LT ++ + + LD + D + P+ V+ S Sbjct: 120 ETPKDRIAFMLSDTKAAVLLTQGKAADGIDCGADIVQLDREAS--DGFSKEPLSSVNDSG 177 Query: 424 NLAYCMYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESI 483 + AY +YTSG+TG PKG++ H S++ ++ + + + L L+ SFD + Sbjct: 178 DTAYIIYTSGSTGTPKGVITPHYSVIRVVQN-TNYIDITEDDVILQLSNYSFDGSVFDIF 236 Query: 484 LPLLAGYQLVIADELQQKDVHALLALVKQAEISVMQTTPSRXXXXXXXXXXXXXXXXXRY 543 LL G LV+ ++ +++ L + + + ++SVM T + R Sbjct: 237 GALLNGASLVMIEKEALLNINRLGSAINEEKVSVMFITTA--LFNMIADIHVDCLSNLRK 294 Query: 544 LLIGGEPLPQALAEQARSILPGGRIFNLYGPTETTIWSTAQEVT-----AGPVNIGKPLK 598 +L GGE + + + ++ ++YGPTE+T+++T + A + IG PL Sbjct: 295 ILFGGERASIPHVRKVLNHVGRDKLIHVYGPTESTVYATYYFINEIDDEAETIPIGSPLA 354 Query: 599 NTQVYILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGD 658 NT V I+++ L PIGVPG L I G G+ +GY N ELTA++FI +P+ PGE++ TGD Sbjct: 355 NTSVLIMDEAGKLVPIGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFIPGERLCKTGD 414 Query: 659 IARWTEEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLV 718 +A+W +G IE++GR D QVKIRG+RIEL EIE +L+ H I +++V + D++ P + Sbjct: 415 LAKWLPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDEESRPYIC 474 Query: 719 AYYTAARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPVTVTLVQP 778 AY TA R +S EL+ FL + LP YMIP +F+++ K+PL +GK+D KALP T Sbjct: 475 AYITANREISLDELKGFLGEKLPEYMIPAYFVKLDKLPLTKNGKVDRKALPEPDRTAGAE 534 Query: 779 GETRKPQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINKCFPVSFQF 838 E P++E EEKL +W+ VL + G+ D F +MGG+S+ M+L+ +I + V Sbjct: 535 NEYEAPRNETEEKLAAVWQDVLHVEKAGIHDHFAQMGGHSLHAMELIAKIKEKMNVEIPL 594 Query: 839 THFIERQTIERIADFIKEAIQEERKEELPFIAADPANRHEPFPLTNVQMAYYLGRSSHFE 898 + TI+ ++ FI+ QE++ + L AADP N HE FPLT +Q+AY +GR FE Sbjct: 595 HQLFKLATIKELSAFIEANHQEDKGDTLVTRAADPENIHEIFPLTGIQLAYLVGRDETFE 654 Query: 899 LGGVSTHSYLEMATELDIRRLNQCLNTLIQRHPALHTVYLPDATQQILPEVPEYTICEYD 958 +GGV+T+ +E ++D+ R L LI RHP L T+ + TQ+IL YTI D Sbjct: 655 IGGVATNLTVEFEADVDLNRFQLTLQKLIDRHPILRTIVFENGTQKILEATQRYTIETQD 714 Query: 959 LSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAFRSSPEESLLCISFDLLIMDAYS 1018 L G+TEE N RI ++R++M+ I +P+VWPLFE+ F E+ ++ D LI D S Sbjct: 715 LRGFTEEEINVRILEQREKMTSKIIDPSVWPLFELKTFMLPGEKKYFFLNVDPLICDGSS 774 Query: 1019 LEILQEEIMALYADRSLQLEELSITFRDYLVGYQQMKSGKWYLEDKEYWLQKVEDFPLAP 1078 ++ L E LY + LQL L +FRDY++ K Y +D++YWL K++ FP AP Sbjct: 775 MKRLIREFKQLYENPGLQLPSLEYSFRDYVLASINFKQTSRYQKDQQYWLDKLDHFPSAP 834 Query: 1079 GLPLLTQPQHVKNPYFKRKSKHYSQQHWRQLKQISQNHNLTPSAVLCTVYAEVLANWSNQ 1138 LPL + P HV P FK+ S W +LK+ +++H+LTP++VLC YA +LA WS Q Sbjct: 835 ELPLKSDPAHVAKPSFKKFSTFLDGHTWNELKKKARHHHLTPTSVLCAAYAYILAYWSRQ 894 Query: 1139 PQFGLNLTLFNRLPLHSDVDKLIGDFTSLLLLEVRMNPN-DSFWEKAGNIQRVLMEALAH 1197 F +NLT+FNR+P H DV +IGDFTSL+LL++ N SFW A N+Q L+EAL H Sbjct: 895 NHFAINLTVFNRIPFHPDVKNMIGDFTSLMLLDIHAEENMSSFWRFALNVQDTLLEALEH 954 Query: 1198 RHFDGIDVMREISKRRALGNKALLPIVFTSALFDNGEDGGEAAENHGEASDGEQSTNGIT 1257 RH+DG+DV+R I+K+ + KA++PIVFTS L +N +D ++ D + T Sbjct: 955 RHYDGVDVIRNIAKKNGMNKKAVMPIVFTSVLSENPDDSFDS------LVDFDNIHFFST 1008 Query: 1258 QTSQVYLDNQVALIHGKMVINWDYISELFDPAVMDAMFAQYLSRIEAILYSREEMGFPAL 1317 +TSQVY+DNQV I+G + I WDY+ ++F+ V+++MF QY++ I+ + S E++ + Sbjct: 1009 RTSQVYIDNQVYEINGGLYITWDYVEQIFEHEVIESMFDQYIAVIQKAV-SGEDVSTIQM 1067 Query: 1318 PASDYTSIQAYNHTEEPIPSKTLHGLFEEAVHQTPYAVAIEADNLSITYKELDDRADKVA 1377 I AYN T++ +K LH LF V P +A++ + +TY+ELD+++++VA Sbjct: 1068 NEKSRQMISAYNDTDQSFDAKPLHELFTGQVKHGPDRMALKHHDEVMTYQELDEKSNQVA 1127 Query: 1378 GSLRSLGVSAGDRVGVIARKEIATFINILGILKSGAAYVPIDPEYPQERVDYIRNHSQCK 1437 L GV GD +GVI ++ + T +N+L +LK+GAAY+P+DP+YP+ER YI++ S CK Sbjct: 1128 RFLIGKGVEKGDYIGVIGKRSLGTIVNLLAVLKTGAAYIPLDPDYPEERKAYIQSKSNCK 1187 Query: 1438 LVLETDYYEK-NCRGQHPAELQRHNLPESLAYVIYTSGSTGNPKGVMISHQAACNTVQDI 1496 ++ D Y+K + A + R + +AYVI+TSGSTG PKGV I+H AA NT+ DI Sbjct: 1188 FLISHDVYDKEHIERFSKAPVDRKVDLDDMAYVIFTSGSTGKPKGVQITHGAAANTIHDI 1247 Query: 1497 NQKFQVGAADRMLGISSLCFDLSVYDIFGAFAAGATLVLVKDQKDIRQLADTLSAQKITI 1556 N+KF V D ++GISSLCFDLSVYD+FGA ++GA+LV++ DQ+D+ L T ++ITI Sbjct: 1248 NEKFNVTEQDNIMGISSLCFDLSVYDVFGALSSGASLVIIDDQRDVFSLKGTAEKERITI 1307 Query: 1557 WNSVPAIMDRVGSEIRAQGIYQE---NLDLRLVLLSGDWIPLHLPETVKQLFPAAKLISC 1613 WNSVPAIM +Y + N LRL+LLSGDWIPL LP T+K+ F A++IS Sbjct: 1308 WNSVPAIMGMTAD------VYPDNELNHHLRLILLSGDWIPLQLPATIKKTFKNAEVISL 1361 Query: 1614 GGATEASIWSIYYPIDEVMPQWTSIPYGMPLANQQFYVLNQQMDYCPLEVSGELYIGGSG 1673 GGATE SIWSIYYPI +V W SIPYG PLANQ+ YVLNQ CP+ V GELYIGG+G Sbjct: 1362 GGATEGSIWSIYYPIQKVEEDWKSIPYGKPLANQKIYVLNQNKQLCPVGVEGELYIGGAG 1421 Query: 1674 VANGYLNDPEKPSHSFIHHPELGYIYRTGDYGVLHRDGCIEFLGRKDQQVKVGGYRIELG 1733 VA+GY++D EK HSFI H ELGYIY+TGDYGVL DG +EFLGRKD QVK+ GYR+E+G Sbjct: 1422 VASGYIHDQEKTEHSFIQHQELGYIYKTGDYGVLKEDGYVEFLGRKDSQVKIRGYRVEMG 1481 Query: 1734 EVEAQLLRCGGVRHAVVLAADGED--KRLGAYLIPDSQSADQAAFINEVRARIAKVLPDY 1791 E+E L+ + A V+ D K L A+++ A+ A +V+ + K LPDY Sbjct: 1482 EIENTLVSHQEITKASVIDYTSPDGIKNLYAFVV-----AENAISQLDVKEFLQKTLPDY 1536 Query: 1792 MIPHYFVVLEQFPLTANGKMDVQALLKL---QPAGNKQTSAYTAPRNDVEERIVNIFKEL 1848 MIP FV +E+ PLT NGK+D + L L A Q P N+ + ++ I+K++ Sbjct: 1537 MIPAKFVQIEEIPLTVNGKVDKRTLHDLAEQHTADEGQRGGRMLPENETQAMLLEIWKDI 1596 Query: 1849 LEADQVGTLDNFFEMGINSVQIAMINNKLKQEFQKEIPLLTLFEYANIHALAGYLSGNDQ 1908 D + +++E+G +S++ I ++ + E+P+ +F+ I AL YL ++ Sbjct: 1597 FGLDSINLDVSYYEIGGDSLKAISIITEINKRMNVEMPISEIFKNDTIIALDHYLKNREE 1656 Query: 1909 NEPDDVPQEQQVTRNQGKERMKQRSAKRR 1937 ++ E + + + KE A++R Sbjct: 1657 SD-----MEHPIQKAREKEYYPTSPAQQR 1680 Score = 837 bits (2161), Expect = 0.0, Method: Compositional matrix adjust. Identities = 582/1930 (30%), Positives = 945/1930 (48%), Gaps = 128/1930 (6%) Query: 14 YWLETFSGEIPLLHLPADHSRPAFKTYRGSAEMFSIPKEQVLEIKQLAAEQEATLYMVLF 73 YWL+ + L P D+ R T+ GS+ + +E I++LA TLY V+ Sbjct: 1859 YWLDVYRDIPSKLDFPYDYKRHHIDTFEGSSVFLEMERELSDHIRKLAKHNGTTLYTVML 1918 Query: 74 AVWNILLAKLSDQEEIIVGVPTSGRNHSDIEHVIGMFVNTLPIKSRISAKLTFAEILHAM 133 + + +LL K ++Q +I+VG +GR H D++ V G+FVNTL +++ + +F L Sbjct: 1919 SAYYVLLNKYTNQTDIVVGTAAAGRLHPDLQDVFGVFVNTLALRNEVDTSYSFKGFLQQT 1978 Query: 134 KANISNALEHQDYPFEDLVSQLQITRDFGRNPLFDVMFXXXXXXXXXXXXXXXXXXELQM 193 K A ++ +YPF+DL+ +L R+ RNPLFD MF ++++ Sbjct: 1979 KERTIAAFDNSEYPFDDLIRKLNGVRESNRNPLFDTMFVLEDARMFTKQKG-----DVKL 2033 Query: 194 KPYPYTTTTSRFDLTLDGEERAGELVFTLEYATDLFTRETVMRLIRYFRTILLEVLKHPA 253 P + ++FD+ + + ++V +EY+T LF ET+ ++ + IL EV ++ Sbjct: 2034 SPIIFELDNAKFDMIFNVLDFEQKIVLNIEYSTSLFKDETIQKIAEDYFRILEEVSENLD 2093 Query: 254 QKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVTFRNQSITY 313 I + QE LL FN T YP+ +HQLF + K P AV F +Q +TY Sbjct: 2094 VALHQIDMISRQEKRTLLESFNHTKTAYPKGKAIHQLFEEQAKRIPDHTAVVFEDQKLTY 2153 Query: 314 DELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPIDPGLPANR 373 +LN G+ PD +V ++ RS DM PIDP P R Sbjct: 2154 RQLNEKANQVARLLREKGVKPDTLVGIMMERSSDMIAAILGVLKAGGAYLPIDPEYPLER 2213 Query: 374 IAYMLDDAGVQVILTNTSV--ENQGNRIVL----DMRSLGLDHGAPLPVPPVHSSRNLAY 427 + YM D+ V+VI+++ + E I L D R G D + V+ S +LAY Sbjct: 2214 MRYMAFDSEVKVIISDVPLAEELTAESIELIHMDDERIAGQDRS---DIDNVNQSGDLAY 2270 Query: 428 CMYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESILPLL 487 +YTSG+TG PKG+++EH+SL+N S G+ + ++SFD F E + Sbjct: 2271 VIYTSGSTGKPKGVMIEHQSLINLCSWHQSCFEVGQNDNSSIYASISFDAFVWELFPYIT 2330 Query: 488 AGYQLVIADELQQKDVHALLALVKQAEISV-MQTTPSRXXXXXXXXXXXXXXXXXRYLLI 546 AG + + ++ + DV L I++ TP R LL Sbjct: 2331 AGATVHVLNQETRLDVEKLNRYFHDHHITISFLPTP------VCEQFTALDNHSLRTLLT 2384 Query: 547 GGEPLPQALAEQARSILPGGRIFNLYGPTETTIWSTAQEVTAGPVNI--GKPLKNTQVYI 604 GG+ L E++ RI N YGPTE T+ +T+ + NI GKP+ N +VYI Sbjct: 2385 GGDKL-NVFKEKSY------RIVNNYGPTENTVVATSFPIDKSHQNIPIGKPIDNVKVYI 2437 Query: 605 LNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGDIARWTE 664 LN +L L P+G G L I G G+ RGY N PELT ++FI+NP+ PGE++Y TGD+A+ Sbjct: 2438 LNKDLQLCPLGASGELCIAGEGLARGYVNRPELTREKFIENPFVPGERMYRTGDLAKMLP 2497 Query: 665 EGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLVAYYTAA 724 +G I++LGR D QVKIRGYRIE EIE +L + IE++ V A+ D +P L AY T Sbjct: 2498 DGDIQFLGRVDQQVKIRGYRIEPGEIENRLLKYEKIEEAAVIAREDGDHDPYLCAYVTVK 2557 Query: 725 RTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPVTVTLVQPGETRKP 784 + V ++R FL K LP YMIPQ+F+++ +PL ++GK+D K+LP ++ P Sbjct: 2558 KEVEPEKIRAFLKKSLPDYMIPQYFVQLDGLPLTVNGKVDKKSLPVPERSVTMDRRYEAP 2617 Query: 785 QDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINKCFPVSFQFTHFIER 844 +D++EEKL+ IW++ L I G+ FFE GG+S++ LV I+K V E Sbjct: 2618 RDQMEEKLVSIWEEALGINKIGINSHFFEAGGHSLKAAALVSTIHKELNVKLPLRQIFET 2677 Query: 845 QTIERIADFIKEAIQEERKEELPFIAADPANRHEPFPLTNVQMAYYLGRSSHFELGGVST 904 TI+ + ++I A +E F + + L++ Q Y+ L + Sbjct: 2678 PTIKGLREYIGAA------KESAFTSIGKTEEKPYYRLSSAQKRLYI-------LSQTGS 2724 Query: 905 HSYLEM------ATELDIRRLNQCLNTLIQRHPALHTVYL---PDATQQILPEVPEYTIC 955 H M + DIRR L +++RH + T ++ + QQI E+ ++ + Sbjct: 2725 HVAYNMPFAMTLEGDFDIRRFENTLKNMVKRHESFRTSFVMIDGEVMQQIEKEI-DFQVA 2783 Query: 956 EYDLSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAFRSSPEESLLCISFDLLIMD 1015 D+ + E K K + F+ PL + + E LL +I D Sbjct: 2784 YSDIGKESAEEKIKSFIRP--------FHLEKAPLLRAEVVKLNEREHLLMFDMHHIISD 2835 Query: 1016 AYSLEILQEEIMALYADRSLQLEELSITFRDYLVGYQQMKSGKWYLEDKEYWLQKVEDFP 1075 S +I +E+ ALY +SL+ I ++DY + +EYWL+ + Sbjct: 2836 GVSTDIFIQELGALYEGKSLK--PFHIQYKDYAEWENSHARSEELKRQEEYWLKTYKG-- 2891 Query: 1076 LAPGLPLLTQPQHVKNPYFKRK-----SKHYSQQHWRQLKQISQNHNLTPSAVLCTVYAE 1130 +P+L P K P K + + +R+L+ +++ + +T +L Y Sbjct: 2892 ---DIPVLDLPTDHKRPLTKSSEGDTVTAAIESETFRKLQHMAKENGVTMYMLLLAGYTA 2948 Query: 1131 VLANWSNQPQFGLNLTLFNRLPLHSDVDKLIGDFTSLLLLEVRMNPNDSFWEKAGNIQRV 1190 +L+ ++ Q + R H D+ LIG F + L + +F ++ Sbjct: 2949 LLSKYTGQEDIIVGTPAAGR--NHEDIQHLIGMFVNTLAIRNHPERKKTFRHYLQEVKEN 3006 Query: 1191 LMEALAHRHFDGIDVMREISKRRALGNKALLPIVFTSALFDNGEDGGEAAENHGEASDGE 1250 ++A ++ + +++ +++ +R + P+ T ++ N + AE G S Sbjct: 3007 TLQAYENQDYPFEELVEKVNIKRDMARN---PLFDTMLVYHNTDVKPFEAE--GLRSRLV 3061 Query: 1251 QSTNGITQTSQVYLDNQVALIHGKMVINWDYISELFDPAVMDAMFAQYLSRIEAILYSRE 1310 + GI++ ++ A + + +Y + LF+ M+ + +S +E Sbjct: 3062 EIKRGISKFDITVTASEAA---DGLRLEVEYSTTLFNKERMERLSEHLISLLEQAA-DHP 3117 Query: 1311 EMGFPAL----PASDYTSIQAYNHTEEPIPSK-TLHGLFEEAVHQTPYAVAIEADNLSIT 1365 ++ + + + +N T+ + T+ LFE+ +TP A+ + +I+ Sbjct: 3118 DIAINQIDVLTKGERHRVLYDFNRTDGVFCKEMTIPELFEKQAEKTPDHPAVAFGDETIS 3177 Query: 1366 YKELDDRADKVAGSLRSLGVSAGDRVGVIARKEIATFINILGILKSGAAYVPIDPEYPQE 1425 Y+EL++RA+ +A +LR GV G++ + I + I+GILK+G AY+PIDP YPQE Sbjct: 3178 YRELNERANSLAFTLRQKGVGPDVIAGILTERSIEMIVGIMGILKAGGAYLPIDPAYPQE 3237 Query: 1426 RVDYIRNHSQCKLVLET-----------DYYEKNCRGQ--HPAELQRHNLPESLAYVIYT 1472 R+ Y+ S ++ D + GQ H L+ PE LAYVIYT Sbjct: 3238 RISYMLKDSDVSVLCAAGDVDLGEAYAGDIIRIDQTGQNDHVENLKHDIKPEHLAYVIYT 3297 Query: 1473 SGSTGNPKGVMISHQAACNTVQDINQKF--QVGAADRMLGISSLCFDLSVYDIFGAFAAG 1530 SGSTG PKGVMI H + N V +N++ + A + ++ FD SV IF A G Sbjct: 3298 SGSTGQPKGVMIEHHSVNNLVHGLNERIYHHLDAHLNVALVAPYIFDASVKQIFAALLFG 3357 Query: 1531 ATLVLVKDQK--DIRQLADTLSAQKITIWNSVPAIMDRVGSEIRAQGIYQENLDLRLVLL 1588 TL +V + D L + S I + + PA ++ + + + DL+ +++ Sbjct: 3358 HTLCIVPRETAWDAMSLIEYYSKNNINVSDMTPAHLNMLAYVDKT----ELEFDLKELIV 3413 Query: 1589 SGDWIPLHLPETVKQLFPAAKLISCG-----GATEASIWSIYYPIDE-VMPQWTSIPYGM 1642 GD + P+ + LF +SC G TE + + + I+ +PQ SIP G Sbjct: 3414 GGDALT---PDVIGGLFHKFPNLSCNITNVYGPTECCVDAASHQIESGKVPQTPSIPIGR 3470 Query: 1643 PLANQQFYVLNQQMDYCPLEVSGELYIGGSGVANGYLNDPEKPSHSFIHHP-ELG-YIYR 1700 PL N Y++++ + P+ ++GEL I G GVA GY+N PE + F+ HP E G +Y+ Sbjct: 3471 PLLNTSIYIVDKDLRPLPVGIAGELCIAGEGVARGYVNRPELTAEKFVDHPFEPGKKMYK 3530 Query: 1701 TGDYGVLHRDGCIEFLGRKDQQVKVGGYRIELGEVEAQLLRCGGVRHAVVLAADGEDKRL 1760 TGD + DG IEFLGR D QVK+ GYRIELGEVE QLL ++ A V++ G+D+ Sbjct: 3531 TGDLAMWLPDGQIEFLGRADHQVKIRGYRIELGEVEQQLLSHEKIKEAAVIS--GKDQNG 3588 Query: 1761 GAYLIPDSQSADQAAFINEVRARIAKVLPDYMIPHYFVVLEQFPLTANGKMDVQALLKLQ 1820 +YL ++DQ VR + + +PDYMIP YFV L++ P T +GK+D AL + Sbjct: 3589 NSYLCA-YFASDQELPAANVRQFLEREMPDYMIPSYFVKLDRLPRTPSGKVDRSAL--PE 3645 Query: 1821 PAGNK-QTSAYTAPRNDVEERIVNIFKELLEADQVGTLDNFFEMGINSVQ-IAMINNKLK 1878 GN + + Y PRN++E ++V +++E+L A+ +G +FF G +S++ + +++ + K Sbjct: 3646 ADGNLIEGTRYDPPRNEIERKLVQVWREILGAEDIGISHHFFAAGGDSIKALQIVSRQAK 3705 Query: 1879 QEFQKEIPLL 1888 + E+ L Sbjct: 3706 MNLKLEMKAL 3715 Score = 670 bits (1728), Expect = 0.0, Method: Compositional matrix adjust. Identities = 521/1951 (26%), Positives = 902/1951 (46%), Gaps = 142/1951 (7%) Query: 14 YWLETF-----SGEIPLLHLPADHSRPAFKTYRGSAEMFSIPKEQVLEIKQLAAEQEATL 68 YWL+ + E+PL PA ++P+FK + + + E+K+ A T Sbjct: 822 YWLDKLDHFPSAPELPLKSDPAHVAKPSFKKFSTFLDGHTWN-----ELKKKARHHHLTP 876 Query: 69 YMVLFAVWNILLAKLSDQEEIIVGVPTSGR--NHSDIEHVIGMFVNTLPIKSRISAKLT- 125 VL A + +LA S Q + + R H D++++IG F + + + ++ Sbjct: 877 TSVLCAAYAYILAYWSRQNHFAINLTVFNRIPFHPDVKNMIGDFTSLMLLDIHAEENMSS 936 Query: 126 FAEILHAMKANISNALEHQDYPFEDLVSQLQITRDFGRNPLFDVMFXXXXXXXXXXXXXX 185 F ++ + ALEH+ Y D++ + + + ++F Sbjct: 937 FWRFALNVQDTLLEALEHRHYDGVDVIRNIAKKNGMNKKAVMPIVFTSVLSENPDDSFDS 996 Query: 186 XXXXELQMKPYPYTTTTSRFDLTLDGEERAGELVFTLEYATDLFTRETVMRLIRYFRTIL 245 + + ++T TS+ + E G L T +Y +F E + + + ++ Sbjct: 997 LVDFD---NIHFFSTRTSQVYIDNQVYEINGGLYITWDYVEQIFEHEVIESMFDQYIAVI 1053 Query: 246 LEVLKHPAQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVT 305 + + + I + N+++ ++++ +N T + + +H+LF +VK P + A+ Sbjct: 1054 QKAVS--GEDVSTIQM--NEKSRQMISAYNDTDQSF-DAKPLHELFTGQVKHGPDRMALK 1108 Query: 306 FRNQSITYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPI 365 ++ +TY EL+ G+ + +I RS+ P+ Sbjct: 1109 HHDEVMTYQELDEKSNQVARFLIGKGVEKGDYIGVIGKRSLGTIVNLLAVLKTGAAYIPL 1168 Query: 366 DPGLPANRIAYMLDDAGVQVILTNTSVENQGNRIVLDMRSLGLDHGAPLPVPPVHSSRNL 425 DP P R AY+ + + ++++ + + ++ + PV ++ Sbjct: 1169 DPDYPEERKAYIQSKSNCKFLISHDVYDKEH-----------IERFSKAPVDRKVDLDDM 1217 Query: 426 AYCMYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESILP 485 AY ++TSG+TG PKG+ + H + N I++ + + + + ++++ FD+ + Sbjct: 1218 AYVIFTSGSTGKPKGVQITHGAAANTIHDINEKFNVTEQDNIMGISSLCFDLSVYDVFGA 1277 Query: 486 LLAGYQLVIADELQQKDVHALLALVKQAEISVMQTTPSRXXXXXXXXXXXXXXXXXRYLL 545 L +G LVI D+ Q+DV +L ++ I++ + P+ R +L Sbjct: 1278 LSSGASLVIIDD--QRDVFSLKGTAEKERITIWNSVPAIMGMTADVYPDNELNHHLRLIL 1335 Query: 546 IGGEPLPQALAEQARSILPGGRIFNLYGPTETTIWST---AQEVTAGPVNI--GKPLKNT 600 + G+ +P L + + +L G TE +IWS Q+V +I GKPL N Sbjct: 1336 LSGDWIPLQLPATIKKTFKNAEVISLGGATEGSIWSIYYPIQKVEEDWKSIPYGKPLANQ 1395 Query: 601 QVYILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGDIA 660 ++Y+LN L P+GV G LYIGG GV GY ++ E T FI ++ IY TGD Sbjct: 1396 KIYVLNQNKQLCPVGVEGELYIGGAGVASGYIHDQEKTEHSFIQ--HQELGYIYKTGDYG 1453 Query: 661 RWTEEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLVAY 720 E+G +E+LGR D QVKIRGYR+E+ EIE L +H I K+ V L A+ Sbjct: 1454 VLKEDGYVEFLGRKDSQVKIRGYRVEMGEIENTLVSHQEITKASVIDYTSPDGIKNLYAF 1513 Query: 721 YTAARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPV----TVTLV 776 A +S +++EFL K LP YMIP F++I +IPL ++GK+D + L + T Sbjct: 1514 VVAENAISQLDVKEFLQKTLPDYMIPAKFVQIEEIPLTVNGKVDKRTLHDLAEQHTADEG 1573 Query: 777 QPGETRKPQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINKCFPVSF 836 Q G P++E + LLEIWK + + + ++E+GG+S++ + ++ EINK V Sbjct: 1574 QRGGRMLPENETQAMLLEIWKDIFGLDSINLDVSYYEIGGDSLKAISIITEINKRMNVEM 1633 Query: 837 QFTHFIERQTIERIADFIKEAIQEERKEELPFIAADPANRHEPFPLTNVQMAYYLGRSSH 896 + + TI + ++K +EE E P A E +P + Q Y+ Sbjct: 1634 PISEIFKNDTIIALDHYLKN--REESDMEHPI---QKAREKEYYPTSPAQQRMYMLSMLE 1688 Query: 897 FELGGVSTHSYLEMATELDIRRLNQCLNTLIQRHPALHT---VYLPDATQQILPEVPEYT 953 E G L + ++ +L L T +QRH L T + + Q+I V Sbjct: 1689 NERGAYHIPMALLVEGRINAMQLESALKTFLQRHEILRTGFEIQNNELIQKIYENVDFRL 1748 Query: 954 ICEYDLSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAFRSSPEESLLCISFDLLI 1013 E + T++ IT + S F+ + PL + +L I+F +I Sbjct: 1749 EYECLDASITDQHALMEITSRYCKESIKPFDLSRPPLMRAKLIKIDDIRHILVINFHHII 1808 Query: 1014 MDAYSLEILQEEIMALYADRSLQLEELSITFRDYLVGYQQMKSGKWYLEDKEYWLQKVED 1073 D S IL +I+ LY++ + L E+++ ++DY+ + + YWL D Sbjct: 1809 SDGVSQGILMNKILELYSN--VPLPEVNVQYKDYVEWNHTFNQSAAMKKQEAYWLDVYRD 1866 Query: 1074 FPLAPGLPLLTQPQHVKNPYFKRKSKHYSQQHWRQLKQISQNHNLTPSAVLCTVYAEVLA 1133 P P + H+ ++ ++++++++ T V+ + Y +L Sbjct: 1867 IPSKLDFPYDYKRHHIDTFEGSSVFLEMERELSDHIRKLAKHNGTTLYTVMLSAYYVLLN 1926 Query: 1134 NWSNQPQFGLNLTLFNRLPLHSDVDKLIGDFTSLLLLEVRMNPNDSFWEKAGNIQRVLME 1193 ++NQ + RL H D+ + G F + L L ++ + SF + + Sbjct: 1927 KYTNQTDIVVGTAAAGRL--HPDLQDVFGVFVNTLALRNEVDTSYSFKGFLQQTKERTIA 1984 Query: 1194 ALAHRHFDGIDVMREISKRRALGNKALLPIVFTSALFDNGEDGGEAAENHGEASDGEQST 1253 A + + D++R+++ R L +F ED + G+ + + Sbjct: 1985 AFDNSEYPFDDLIRKLNGVRESNRNPLFDTMFVL------EDARMFTKQKGDV----KLS 2034 Query: 1254 NGITQTSQVYLDN--QVALIHGKMVINWDYISELFDPAVMDAMFAQYLSRIEAI------ 1305 I + D V K+V+N +Y + LF + + Y +E + Sbjct: 2035 PIIFELDNAKFDMIFNVLDFEQKIVLNIEYSTSLFKDETIQKIAEDYFRILEEVSENLDV 2094 Query: 1306 ------LYSREEMGFPALPASDYTSIQAYNHTEEPIPS-KTLHGLFEEAVHQTPYAVAIE 1358 + SR+E T ++++NHT+ P K +H LFEE + P A+ Sbjct: 2095 ALHQIDMISRQE---------KRTLLESFNHTKTAYPKGKAIHQLFEEQAKRIPDHTAVV 2145 Query: 1359 ADNLSITYKELDDRADKVAGSLRSLGVSAGDRVGVIARKEIATFINILGILKSGAAYVPI 1418 ++ +TY++L+++A++VA LR GV VG++ + ILG+LK+G AY+PI Sbjct: 2146 FEDQKLTYRQLNEKANQVARLLREKGVKPDTLVGIMMERSSDMIAAILGVLKAGGAYLPI 2205 Query: 1419 DPEYPQERVDYIRNHSQCKLVLE---------------TDYYEKNCRGQHPAELQRHNLP 1463 DPEYP ER+ Y+ S+ K+++ ++ GQ +++ N Sbjct: 2206 DPEYPLERMRYMAFDSEVKVIISDVPLAEELTAESIELIHMDDERIAGQDRSDIDNVNQS 2265 Query: 1464 ESLAYVIYTSGSTGNPKGVMISHQAACNTVQDINQKFQVGAADRMLGISSLCFDLSVYDI 1523 LAYVIYTSGSTG PKGVMI HQ+ N F+VG D +S+ FD V+++ Sbjct: 2266 GDLAYVIYTSGSTGKPKGVMIEHQSLINLCSWHQSCFEVGQNDNSSIYASISFDAFVWEL 2325 Query: 1524 FGAFAAGATLVLVKDQK--DIRQLADTLSAQKITIWNSVPAIMDRVGSEIRAQGIYQENL 1581 F AGAT+ ++ + D+ +L ITI + +P + + Q +N Sbjct: 2326 FPYITAGATVHVLNQETRLDVEKLNRYFHDHHITI-SFLP-------TPVCEQFTALDNH 2377 Query: 1582 DLRLVLLSGDWIPLHLPETVKQLFPAAKLISCGGATEASIWSIYYPIDEVMPQWTSIPYG 1641 LR +L GD + + ++ + +++ G TE ++ + +PID+ +IP G Sbjct: 2378 SLRTLLTGGDKLNVFKEKSYR-------IVNNYGPTENTVVATSFPIDK---SHQNIPIG 2427 Query: 1642 MPLANQQFYVLNQQMDYCPLEVSGELYIGGSGVANGYLNDPEKPSHSFIHHPEL--GYIY 1699 P+ N + Y+LN+ + CPL SGEL I G G+A GY+N PE FI +P + +Y Sbjct: 2428 KPIDNVKVYILNKDLQLCPLGASGELCIAGEGLARGYVNRPELTREKFIENPFVPGERMY 2487 Query: 1700 RTGDYGVLHRDGCIEFLGRKDQQVKVGGYRIELGEVEAQLLRCGGVRHAVVLA-ADGE-D 1757 RTGD + DG I+FLGR DQQVK+ GYRIE GE+E +LL+ + A V+A DG+ D Sbjct: 2488 RTGDLAKMLPDGDIQFLGRVDQQVKIRGYRIEPGEIENRLLKYEKIEEAAVIAREDGDHD 2547 Query: 1758 KRLGAYLIPDSQSADQAAFINEVRARIAKVLPDYMIPHYFVVLEQFPLTANGKMDVQALL 1817 L AY+ + + ++RA + K LPDYMIP YFV L+ PLT NGK+D ++L Sbjct: 2548 PYLCAYVTVKKEVEPE-----KIRAFLKKSLPDYMIPQYFVQLDGLPLTVNGKVDKKSL- 2601 Query: 1818 KLQPAGNKQTSA---YTAPRNDVEERIVNIFKELLEADQVGTLDNFFEMGINSVQIAMIN 1874 P + + Y APR+ +EE++V+I++E L +++G +FFE G +S++ A + Sbjct: 2602 ---PVPERSVTMDRRYEAPRDQMEEKLVSIWEEALGINKIGINSHFFEAGGHSLKAAALV 2658 Query: 1875 NKLKQEFQKEIPLLTLFEYANIHALAGYLSG 1905 + + +E ++PL +FE I L Y+ Sbjct: 2659 STIHKELNVKLPLRQIFETPTIKGLREYIGA 2689 Score = 432 bits (1112), Expect = e-118, Method: Compositional matrix adjust. Identities = 272/867 (31%), Positives = 443/867 (51%), Gaps = 26/867 (2%) Query: 14 YWLETFSGEIPLLHLPADHSRPAFKTYRGSAEMFSIPKEQVLEIKQLAAEQEATLYMVLF 73 YW + G LPA + + Y G ++ S+ KE +I ++A T+ VL Sbjct: 4397 YWKDYLKGYESRSELPAFNRGATSEEYGGKEKVISVSKELTTKITRIAKTHHVTINTVLQ 4456 Query: 74 AVWNILLAKLSDQEEIIVGVPTSGRNH--SDIEHVIGMFVNTLPIKSRISAKLTFAEILH 131 +W ++LAK ++ +E++ G SGR IE ++G+F++T+P + +F E+L Sbjct: 4457 GIWGMILAKYNNTDEVVFGTVVSGREAPVDGIEEMVGLFIHTIPTRISFEGARSFKEVLK 4516 Query: 132 AMKANISNALEHQDYPFEDLVSQLQITRDFGRNPLFDVMFXXXXXXXXXXXXXXXXXXEL 191 +A ++E Y + +L S++Q + R + VM Sbjct: 4517 KTQAE---SIESNRYSYMNL-SEIQELSEMKRELITHVMAFQNYAFDEELFRSQSGESGF 4572 Query: 192 QMKPYPYTTTTSRFDLTLDGEERAGELVFTLEYATDLFTRETVMRLIRYFRTILLEVLKH 251 +++ + + +D L G +L L + +++ + L ++ T+ +V + Sbjct: 4573 ELEGV-HGKERTNYDFNLTGVLEDEQLKLKLTFNENVYDNTIIETLEKHIITVAEQVAED 4631 Query: 252 PAQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVTFRNQSI 311 Q I+L +E R+L+ FN T YP+ +H+LF + + P Q A+ F +Q + Sbjct: 4632 ETQTLRDINLVSKEEKHRILHIFNDTKTNYPKDKPLHELFEEQAMKTPDQTALVFGSQRM 4691 Query: 312 TYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPIDPGLPA 371 TY ELN GIG I A+I RS +M PIDP P Sbjct: 4692 TYRELNKKANQTARLLREKGIGRGSIAAIIADRSFEMIIGIIGILKAGGAYLPIDPETPR 4751 Query: 372 NRIAYMLDDAGVQVILTNTSVENQGNRIVLDMRSLGLDHGAPLPVPPVHSSRNLAYCMYT 431 +RI YML ++G +++T S+ + +D+RS L +P V+SS + AY +YT Sbjct: 4752 DRIDYMLKNSGAALLVTTDSLLQPFDIRTVDLRSDELHLLGEENLPRVNSSSDTAYIVYT 4811 Query: 432 SGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESILPLLAGYQ 491 SG+TG PKG+++ H S ++ + + + L L+ SFD + LL G Sbjct: 4812 SGSTGTPKGVVIPHYSAARVVQN-TNYIDITEDDAILQLSNYSFDGSVFDIFGALLNGAS 4870 Query: 492 LVIADELQQKDVHALLALVKQAEISVMQTTPSRXXXXXXXXXXXXXXXXXRYLLIGGEPL 551 LV+ ++ + H L ++K+ ++SVM T + R +L GGE Sbjct: 4871 LVLIEKETVLNTHELAEVIKKEQVSVMFITTA--LFNTLADINIGCLAKLRKILFGGE-- 4926 Query: 552 PQALAEQARSILP-GGR--IFNLYGPTETTIWSTAQEVT-----AGPVNIGKPLKNTQVY 603 +A R +L GR + ++YGPTE+T+++T + A + IG PL NT V Sbjct: 4927 -RASIPHVRKVLDHAGRDKLIHVYGPTESTVYATYYFINEIDEKADTIPIGSPLANTSVL 4985 Query: 604 ILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGDIARWT 663 I+++ L PIGVPG L I G G+ +GY ELTA++FI +P+ PGE++Y TGD+A+W Sbjct: 4986 IMDEAGKLVPIGVPGELCIAGDGLSKGYLKREELTAEKFIPHPFMPGERLYKTGDLAKWL 5045 Query: 664 EEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLVAYYTA 723 +G IE++GR D QVKIRG+RIEL EIE +L+ H I +++V + D ++ P + AY TA Sbjct: 5046 PDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDGENRPYICAYITA 5105 Query: 724 ARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPVTVTLVQPGETRK 783 R +S EL+ FL + LP YMIP +F+ + K+PL +GK+D KALP + E Sbjct: 5106 KREISLDELKGFLGEKLPEYMIPAYFVNMDKLPLTKNGKVDRKALPEPDRSAGTEAEYEA 5165 Query: 784 PQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINKCFPVSFQFTHFIE 843 P++ VE++++ I + VL G+ FF+ GGNS++ MQ V+ INK F + + + F + Sbjct: 5166 PRNYVEQRIISILEDVLGTERMGISCHFFDKGGNSLKAMQAVHSINKTFGIDMRISTFFK 5225 Query: 844 RQTIERIADFI-----KEAIQEERKEE 865 T + +A F+ + A+ EE EE Sbjct: 5226 HPTAKSLARFVLTAEAESAVSEEYAEE 5252 Score = 374 bits (959), Expect = e-101, Method: Compositional matrix adjust. Identities = 297/1074 (27%), Positives = 519/1074 (48%), Gaps = 96/1074 (8%) Query: 880 FPLTNVQMAYYLGRSSHFELGGVSTHSYLEMATELDIRRLNQCLNTLIQRHPALHTVYLP 939 +PL N+Q + G +E+ + L + + +++RH L + Sbjct: 4209 YPLANMQKGMLFHNAMDQTSGAYLQQIVIELKGRVHPDILEESFHEIVKRHEILRASFEY 4268 Query: 940 DAT---QQILPEVPEYTICEYDLSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAF 996 + T +QI+ + DL+G +++ I F+ + L + Sbjct: 4269 EITSEPRQIIARERKTPFASIDLTGENRTRQHRFIETYLKEDQEKGFDLSSEALMRVCLI 4328 Query: 997 RSSPEESLLCISFDLLIMDAYSLEILQEEIMALYAD----RSLQLEELSITFRDYLVGYQ 1052 R + E L S +++D + L I+ E+ +LY S +L+E + DY+ Sbjct: 4329 RMNDESYRLIWSHHHILLDGWCLGIVLSELFSLYGKIMKGESRRLKEPK-PYGDYI---- 4383 Query: 1053 QMKSGKWYLE-DKE----YWLQKVEDFPLAPGLPLLTQPQHVKNPYFKRKSKHYSQQHWR 1107 KW E DKE YW ++ + LP + + K K S++ Sbjct: 4384 -----KWLEEQDKEEAAAYWKDYLKGYESRSELPAFNRGATSEEYGGKEKVISVSKELTT 4438 Query: 1108 QLKQISQNHNLTPSAVLCTVYAEVLANWSNQPQFGLNLTLFNRLPLHSDVDKLIGDFTSL 1167 ++ +I++ H++T + VL ++ +LA ++N + + R +++++G F Sbjct: 4439 KITRIAKTHHVTINTVLQGIWGMILAKYNNTDEVVFGTVVSGREAPVDGIEEMVGLFIHT 4498 Query: 1168 LLLEVRMNPNDSFWEKAGNIQRVLMEA--LAHRHFDGIDVMREISKRRALGNKALLPIVF 1225 + + SF E Q +E+ ++ + I + E+ + A F Sbjct: 4499 IPTRISFEGARSFKEVLKKTQAESIESNRYSYMNLSEIQELSEMKRELITHVMAFQNYAF 4558 Query: 1226 TSALF--DNGEDGGEAAENHGEASDGEQSTNGITQTSQVYLDNQVALIHGKMVINWDYIS 1283 LF +GE G E E G++ TN + V D Q+ L K+ N Sbjct: 4559 DEELFRSQSGESGFEL-----EGVHGKERTNYDFNLTGVLEDEQLKL---KLTFN----E 4606 Query: 1284 ELFDPAVMDAMFAQYLSRIEAI------------LYSREEMGFPALPASDYTSIQAYNHT 1331 ++D +++ + ++ E + L S+EE + + +N T Sbjct: 4607 NVYDNTIIETLEKHIITVAEQVAEDETQTLRDINLVSKEE---------KHRILHIFNDT 4657 Query: 1332 EEPIPS-KTLHGLFEEAVHQTPYAVAIEADNLSITYKELDDRADKVAGSLRSLGVSAGDR 1390 + P K LH LFEE +TP A+ + +TY+EL+ +A++ A LR G+ G Sbjct: 4658 KTNYPKDKPLHELFEEQAMKTPDQTALVFGSQRMTYRELNKKANQTARLLREKGIGRGSI 4717 Query: 1391 VGVIARKEIATFINILGILKSGAAYVPIDPEYPQERVDYIRNHSQCKLVLETDYYEK--- 1447 +IA + I I+GILK+G AY+PIDPE P++R+DY+ +S L++ TD + Sbjct: 4718 AAIIADRSFEMIIGIIGILKAGGAYLPIDPETPRDRIDYMLKNSGAALLVTTDSLLQPFD 4777 Query: 1448 ----NCRGQHPAELQRHNLPE-----SLAYVIYTSGSTGNPKGVMISHQAACNTVQDINQ 1498 + R L NLP AY++YTSGSTG PKGV+I H +A VQ+ N Sbjct: 4778 IRTVDLRSDELHLLGEENLPRVNSSSDTAYIVYTSGSTGTPKGVVIPHYSAARVVQNTNY 4837 Query: 1499 KFQVGAADRMLGISSLCFDLSVYDIFGAFAAGATLVLVKDQK--DIRQLADTLSAQKITI 1556 + D +L +S+ FD SV+DIFGA GA+LVL++ + + +LA+ + +++++ Sbjct: 4838 -IDITEDDAILQLSNYSFDGSVFDIFGALLNGASLVLIEKETVLNTHELAEVIKKEQVSV 4896 Query: 1557 WNSVPAIMDRVGSEIRAQGIYQENLDLRLVLLSGDWIPLHLPETVKQLFPAA--KLISCG 1614 A+ + + ++I + + LR +L G+ +P K L A KLI Sbjct: 4897 MFITTALFNTL-ADINIGCLAK----LRKILFGGERAS--IPHVRKVLDHAGRDKLIHVY 4949 Query: 1615 GATEASIWSIYYPIDEVMPQWTSIPYGMPLANQQFYVLNQQMDYCPLEVSGELYIGGSGV 1674 G TE+++++ YY I+E+ + +IP G PLAN ++++ P+ V GEL I G G+ Sbjct: 4950 GPTESTVYATYYFINEIDEKADTIPIGSPLANTSVLIMDEAGKLVPIGVPGELCIAGDGL 5009 Query: 1675 ANGYLNDPEKPSHSFIHHPEL--GYIYRTGDYGVLHRDGCIEFLGRKDQQVKVGGYRIEL 1732 + GYL E + FI HP + +Y+TGD DG IEF+GR D QVK+ G+RIEL Sbjct: 5010 SKGYLKREELTAEKFIPHPFMPGERLYKTGDLAKWLPDGNIEFIGRIDHQVKIRGFRIEL 5069 Query: 1733 GEVEAQLLRCGGVRHAVV-LAADGEDK-RLGAYLIPDSQSADQAAFINEVRARIAKVLPD 1790 GE+E++L + +V + DGE++ + AY+ +A + ++E++ + + LP+ Sbjct: 5070 GEIESRLEMHEDINETIVTVREDGENRPYICAYI-----TAKREISLDELKGFLGEKLPE 5124 Query: 1791 YMIPHYFVVLEQFPLTANGKMDVQALLKLQPAGNKQTSA-YTAPRNDVEERIVNIFKELL 1849 YMIP YFV +++ PLT NGK+D +AL +P + T A Y APRN VE+RI++I +++L Sbjct: 5125 YMIPAYFVNMDKLPLTKNGKVDRKAL--PEPDRSAGTEAEYEAPRNYVEQRIISILEDVL 5182 Query: 1850 EADQVGTLDNFFEMGINSVQIAMINNKLKQEFQKEIPLLTLFEYANIHALAGYL 1903 +++G +FF+ G NS++ + + + F ++ + T F++ +LA ++ Sbjct: 5183 GTERMGISCHFFDKGGNSLKAMQAVHSINKTFGIDMRISTFFKHPTAKSLARFV 5236 >O68006.1 BACA_BACLI Bacitracin synthetase 1 ATP-dependent isoleucine adenylase ATP-dependent cysteine adenylase ATP-dependent leucine adenylase ATP-dependent glutamate adenylase ATP-dependent isoleucine adenylase Glutamate racemase EC=5.1.1.3 Length = 5255 Score = 1270 bits (3286), Expect = 0.0, Method: Compositional matrix adjust. Identities = 685/1709 (40%), Positives = 1012/1709 (59%), Gaps = 49/1709 (2%) Query: 248 VLKHPAQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVTFR 307 V KH + G+ H E + +L+ FN T +YP++ T+H+LF + + P A+ F Sbjct: 2 VAKHSLE-NGVFHKMTENEKELILH-FNNTKTDYPKNKTLHELFEEQAMKTPDHTALVFG 59 Query: 308 NQSITYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPIDP 367 Q +TY ELN GIG I A+I RS +M PIDP Sbjct: 60 AQRMTYRELNEKANQTARLLREKGIGRGSIAAIIADRSFEMIIGIIGILKAGGAYLPIDP 119 Query: 368 GLPANRIAYMLDDAGVQVILTN----TSVENQGNRIVLDMRSLGLDHGAPLPVPPVHSSR 423 P +RIA+ML D V+LT ++ + + + LD + D + P+ V+ S Sbjct: 120 ETPKDRIAFMLSDTKAAVLLTQGKAADGIDCEADIVQLDREAS--DGFSKEPLSSVNDSG 177 Query: 424 NLAYCMYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESI 483 + AY +YTSG+TG PKG++ H S++ ++ + + L L+ SFD + Sbjct: 178 DTAYIIYTSGSTGTPKGVITPHYSVIRVVQN-TNYIDITEDNVILQLSNYSFDGSVFDIF 236 Query: 484 LPLLAGYQLVIADELQQKDVHALLALVKQAEISVMQTTPSRXXXXXXXXXXXXXXXXXRY 543 LL G LV+ ++ +++ L + + + ++SVM T + R Sbjct: 237 GALLNGASLVMIEKEALLNINRLGSAINEEKVSVMFITTA--LFNMIADIHVDCLSNLRK 294 Query: 544 LLIGGEPLPQALAEQARSILPGGRIFNLYGPTETTIWSTAQEVT-----AGPVNIGKPLK 598 +L GGE + + + ++ ++YGPTE+T+++T + A + IG PL Sbjct: 295 ILFGGERASIPHVRKVLNHVGRDKLIHVYGPTESTVYATYYFINEIDDEAETIPIGSPLA 354 Query: 599 NTQVYILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGD 658 NT V I+++ L PIGVPG L I G G+ +GY N ELTA++FI +P+ PGE++Y TGD Sbjct: 355 NTSVLIMDEAGKLVPIGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFIPGERLYKTGD 414 Query: 659 IARWTEEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLV 718 +A+W +G IE++GR D QVKIRG+RIEL EIE +L+ H I +++V + D++ P + Sbjct: 415 LAKWLPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDEESRPYIC 474 Query: 719 AYYTAARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPVTVTLVQP 778 AY TA R +S EL+ FL + LP YMIP +F+++ K+PL +GK+D KALP T Sbjct: 475 AYITANREISLDELKGFLGEKLPEYMIPAYFVKLDKLPLTKNGKVDRKALPEPDRTAGAE 534 Query: 779 GETRKPQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINKCFPVSFQF 838 E P++E EEKL +W+ VL + G+ D F +MGG+S+ M+L+ +I + V Sbjct: 535 NEYEAPRNETEEKLAAVWQDVLHVEKAGIHDHFAQMGGHSLHAMELIAKIKEKMNVEIPL 594 Query: 839 THFIERQTIERIADFIKEAIQEERKEELPFIAADPANRHEPFPLTNVQMAYYLGRSSHFE 898 + TI+ ++ FI+ QE++ + L AADP N HE FPLT +Q+AY +GR FE Sbjct: 595 HQLFKLATIKELSAFIEANHQEDKGDTLVTRAADPENIHEIFPLTGIQLAYLVGRDETFE 654 Query: 899 LGGVSTHSYLEMATELDIRRLNQCLNTLIQRHPALHTVYLPDATQQILPEVPEYTICEYD 958 +GGV+T+ +E ++D+ R L LI RHP L T+ + TQ+IL YTI D Sbjct: 655 IGGVATNLTVEFEADVDLNRFQLTLQKLIDRHPILRTIVFENGTQKILEATQRYTIETQD 714 Query: 959 LSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAFRSSPEESLLCISFDLLIMDAYS 1018 L G+TEE N RI ++R++M+ I +P+VWPLFE+ F E+ ++ D LI D S Sbjct: 715 LRGFTEEEINVRILEQREKMTSKIIDPSVWPLFELKTFMLPGEKKYFFLNVDPLICDDSS 774 Query: 1019 LEILQEEIMALYADRSLQLEELSITFRDYLVGYQQMKSGKWYLEDKEYWLQKVEDFPLAP 1078 ++ L E LY + LQL L +FRDY++ K Y +D++YWL K++ FP AP Sbjct: 775 MKRLIREFKQLYENPGLQLPSLEYSFRDYVLASINFKQTSRYQKDQQYWLDKLDHFPSAP 834 Query: 1079 GLPLLTQPQHVKNPYFKRKSKHYSQQHWRQLKQISQNHNLTPSAVLCTVYAEVLANWSNQ 1138 LPL + P HV P FK+ S W +LK+ +++H+LTP++VLC YA +LA WS Q Sbjct: 835 ELPLKSDPAHVAKPSFKKFSTFLDGHTWNELKKKARHHHLTPTSVLCAAYAYILAYWSRQ 894 Query: 1139 PQFGLNLTLFNRLPLHSDVDKLIGDFTSLLLLEVRMNPN-DSFWEKAGNIQRVLMEALAH 1197 F +NLT+FNR+P H DV +IGDFTSL+LL++ N SFW A N+Q L+EAL H Sbjct: 895 NHFAINLTVFNRIPFHPDVKNMIGDFTSLMLLDIHAEENMSSFWRFALNVQDTLLEALEH 954 Query: 1198 RHFDGIDVMREISKRRALGNKALLPIVFTSALFDNGEDGGEAAENHGEASDGEQSTNGIT 1257 RH+DG+DV+R I+K+ + KA++PIVFTS L +N +D ++ D + T Sbjct: 955 RHYDGVDVIRNIAKKNGMNKKAVMPIVFTSVLSENPDDSFDS------LVDFDNIHFFST 1008 Query: 1258 QTSQVYLDNQVALIHGKMVINWDYISELFDPAVMDAMFAQYLSRIEAILYSREEMGFPAL 1317 +TSQVY+DNQV I+G + I WDY+ ++F+ V+++MF QY++ I+ + S E++ + Sbjct: 1009 RTSQVYIDNQVYEINGGLYITWDYVEQIFEHEVIESMFDQYIAVIQKAV-SGEDVSTIQM 1067 Query: 1318 PASDYTSIQAYNHTEEPIPSKTLHGLFEEAVHQTPYAVAIEADNLSITYKELDDRADKVA 1377 I AYN T++ +K LH LF V P +A++ + +TY+ELD+++++VA Sbjct: 1068 NEKSRQMISAYNDTDQSFDAKPLHELFTGQVKHGPDRMALKHHDEVMTYQELDEKSNQVA 1127 Query: 1378 GSLRSLGVSAGDRVGVIARKEIATFINILGILKSGAAYVPIDPEYPQERVDYIRNHSQCK 1437 L GV GD +GVI ++ + T +N+L +LK+GAAY+P+DP+YP+ER YI++ S CK Sbjct: 1128 RFLIGKGVEKGDYIGVIGKRSLGTIVNLLAVLKTGAAYIPLDPDYPEERKAYIQSKSNCK 1187 Query: 1438 LVLETDYYEK-NCRGQHPAELQRHNLPESLAYVIYTSGSTGNPKGVMISHQAACNTVQDI 1496 + D Y+K + A + R + +AYVI+TSGSTG PKGV I+H NT+ DI Sbjct: 1188 FFISHDVYDKEHIERFSKAPVDRKVDLDDMAYVIFTSGSTGKPKGVQITHVPQRNTILDI 1247 Query: 1497 NQKFQVGAADRMLGISSLCFDLSVYDIFGAFAAGATLVLVKDQKDIRQLADTLSAQKITI 1556 N+KF V D ++GISSLCFDLSVYD+FGA ++GA+LV++ DQ+D+ L +T ++ITI Sbjct: 1248 NEKFNVTEQDNIMGISSLCFDLSVYDVFGALSSGASLVIIDDQRDVFSLKETAEKERITI 1307 Query: 1557 WNSVPAIMDRVGSEIRAQGIYQE---NLDLRLVLLSGDWIPLHLPETVKQLFPAAKLISC 1613 WNSVPAIM +Y + N LRL+LLSGDWIPL LP T+K+ F A++IS Sbjct: 1308 WNSVPAIMGMTAD------VYPDNELNHHLRLILLSGDWIPLQLPATIKKTFKNAEVISL 1361 Query: 1614 GGATEASIWSIYYPIDEVMPQWTSIPYGMPLANQQFYVLNQQMDYCPLEVSGELYIGGSG 1673 GGATE SIWSIYYPI +V W SIPYG PLANQ+ YVLNQ CP+ V GELYIGG+G Sbjct: 1362 GGATEGSIWSIYYPIQKVEEDWKSIPYGKPLANQKIYVLNQNKQLCPVGVEGELYIGGAG 1421 Query: 1674 VANGYLNDPEKPSHSFIHHPELGYIYRTGDYGVLHRDGCIEFLGRKDQQVKVGGYRIELG 1733 VA+GY++D EK HSFI H ELGYIY+TGDYGVL DG +EFLGRKD QVK+ GYR+E+G Sbjct: 1422 VASGYIHDQEKTEHSFIQHQELGYIYKTGDYGVLKEDGYVEFLGRKDSQVKIRGYRVEMG 1481 Query: 1734 EVEAQLLRCGGVRHAVVLAADGED--KRLGAYLIPDSQSADQAAFINEVRARIAKVLPDY 1791 E+E L+ + A V+ D K L A+++ A+ A +V+ + K LPDY Sbjct: 1482 EIENTLVSHQEITKASVIDYTSPDGIKNLYAFVV-----AENAISQLDVKEFLQKTLPDY 1536 Query: 1792 MIPHYFVVLEQFPLTANGKMDVQALLKL---QPAGNKQTSAYTAPRNDVEERIVNIFKEL 1848 MIP FV +E+ PLT NGK+D + L L A Q P N+ + ++ I+K++ Sbjct: 1537 MIPAKFVQIEEIPLTVNGKVDKRTLHDLAEQHTADEGQRGGRMLPENETQAMLLEIWKDI 1596 Query: 1849 LEADQVGTLDNFFEMGINSVQIAMINNKLKQEFQKEIPLLTLFEYANIHALAGYLSGNDQ 1908 D + +++E+G +S++ I ++ + E+P+ +F+ I AL YL ++ Sbjct: 1597 FGLDSINLDVSYYEIGGDSLKAISIITEINKRMNVEMPISEIFKNDTIIALDHYLKNREE 1656 Query: 1909 NEPDDVPQEQQVTRNQGKERMKQRSAKRR 1937 ++ E + + + KE A++R Sbjct: 1657 SD-----MEHPIQKAREKEYYPTSPAQQR 1680 Score = 838 bits (2165), Expect = 0.0, Method: Compositional matrix adjust. Identities = 585/1957 (29%), Positives = 958/1957 (48%), Gaps = 129/1957 (6%) Query: 14 YWLETFSGEIPLLHLPADHSRPAFKTYRGSAEMFSIPKEQVLEIKQLAAEQEATLYMVLF 73 YWL+ + L P D+ R T+ GS+ + +E I++LA TLY V+ Sbjct: 1859 YWLDVYRDIPSKLDFPYDYKRHHIDTFEGSSVFLEMERELSDHIRKLAKHNGTTLYTVML 1918 Query: 74 AVWNILLAKLSDQEEIIVGVPTSGRNHSDIEHVIGMFVNTLPIKSRISAKLTFAEILHAM 133 + + +LL K ++Q +I+VG +GR H D++ V G+FVNTL +++ + +F E L Sbjct: 1919 SAYYVLLNKYTNQTDIVVGTAAAGRLHPDLQDVFGVFVNTLALRNEVDTSYSFKEFLQQT 1978 Query: 134 KANISNALEHQDYPFEDLVSQLQITRDFGRNPLFDVMFXXXXXXXXXXXXXXXXXXELQM 193 K A ++ +YPF+DL+ +L R+ RNPLFD MF ++++ Sbjct: 1979 KERTIAAFDNSEYPFDDLIRKLNGVRESNRNPLFDTMFVLEDARMFTKQKG-----DVKL 2033 Query: 194 KPYPYTTTTSRFDLTLDGEERAGELVFTLEYATDLFTRETVMRLIRYFRTILLEVLKHPA 253 P + ++FD+ + + ++V +EY+T LF ET+ ++ + IL EV ++ Sbjct: 2034 SPIIFELDNAKFDMIFNVLDFEQKIVLNIEYSTSLFKDETIQKIAEDYFRILEEVSENLD 2093 Query: 254 QKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVTFRNQSITY 313 I + QE LL FN T YP+ +HQLF + K P AV F +Q +TY Sbjct: 2094 VALHQIDMISRQEKRTLLESFNHTKTAYPKGKAIHQLFEEQAKRIPDHTAVVFEDQKLTY 2153 Query: 314 DELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPIDPGLPANR 373 +LN G+ PD +V ++ RS DM PIDP P R Sbjct: 2154 RQLNEKANQVARLLREKGVKPDTLVGIMMERSSDMIAAILGVLKAGGAYLPIDPEYPPER 2213 Query: 374 IAYMLDDAGVQVILTNTSV--ENQGNRIVL----DMRSLGLDHGAPLPVPPVHSSRNLAY 427 + YM D+ V+VI+++ + E I L D R G D + V+ S +LAY Sbjct: 2214 MRYMAFDSEVKVIISDVPLAEELTAESIELIHMDDERIAGQDRS---DIDNVNQSGDLAY 2270 Query: 428 CMYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESILPLL 487 +YTSG+TG PKG+++EH+SL+N S G+ + ++SFD F E + Sbjct: 2271 VIYTSGSTGKPKGVMIEHQSLINLCSWHQSCFEVGQNDNSSIYASISFDAFVWELFPYIT 2330 Query: 488 AGYQLVIADELQQKDVHALLALVKQAEISV-MQTTPSRXXXXXXXXXXXXXXXXXRYLLI 546 AG + + ++ + DV L I++ TP R LL Sbjct: 2331 AGATVHVLNQETRLDVEKLNRYFHDHHITISFLPTP------VCEQFTALDNHSLRTLLT 2384 Query: 547 GGEPLPQALAEQARSILPGGRIFNLYGPTETTIWSTAQEVTAGPVNI--GKPLKNTQVYI 604 GG+ L E++ I+ N YGPTE T+ +T+ + NI GKP+ N +VYI Sbjct: 2385 GGDKL-NVFKEKSYQIV------NNYGPTENTVVATSFPIDKSHQNIPIGKPIDNVKVYI 2437 Query: 605 LNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGDIARWTE 664 LN +L L P+G G L I G G+ RGY N PELT ++FI NP+ PGE++Y TGD+A+ Sbjct: 2438 LNKDLQLCPLGASGELCIAGEGLARGYVNRPELTREKFIGNPFVPGERMYRTGDLAKMLP 2497 Query: 665 EGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLVAYYTAA 724 +G I++LGR D QVKIRGYRIE EIE +L + IE++ V A+ D +P L AY T Sbjct: 2498 DGNIQFLGRVDQQVKIRGYRIEPGEIENRLLKYEKIEEAAVIAREDGDHDPYLCAYVTVK 2557 Query: 725 RTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPVTVTLVQPGETRKP 784 + V ++R FL K LP YMIPQ+F+++ +PL ++GK+D K+LP ++ P Sbjct: 2558 KEVEPEKIRAFLKKSLPDYMIPQYFVQLDGLPLTVNGKVDKKSLPVPERSVTMDRRYEAP 2617 Query: 785 QDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINKCFPVSFQFTHFIER 844 +D++EEKL+ IW++ L I G+ FFE GG+S++ LV I+K V E Sbjct: 2618 RDQMEEKLVSIWEEALGINKIGINSHFFEAGGHSLKAAALVSTIHKELNVKLPLRQIFET 2677 Query: 845 QTIERIADFIKEAIQEERKEELPFIAADPANRHEP-FPLTNVQMAYYLGRSSHFELGGVS 903 TI+ + D R+ + +I D +P + L++ Q Y+ L Sbjct: 2678 PTIKGLRDI------SVRRRKCFYI--DRKTEEKPYYRLSSAQKRLYI-------LSQTG 2722 Query: 904 THSYLEM------ATELDIRRLNQCLNTLIQRHPALHTVYL---PDATQQILPEVPEYTI 954 +H M + DIRR L +++RH + T ++ + QQI E+ ++ + Sbjct: 2723 SHVAYNMPFAMTLEGDFDIRRFENTLKNMVKRHESFRTSFVMIDGEVMQQIEKEI-DFQV 2781 Query: 955 CEYDLSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAFRSSPEESLLCISFDLLIM 1014 D+ + E K K + F+ PL + + E LL +I Sbjct: 2782 AYSDIGKESAEEKIKSFIRP--------FHLEKAPLLRAEVVKLNEREHLLMFDMHHIIS 2833 Query: 1015 DAYSLEILQEEIMALYADRSLQLEELSITFRDYLVGYQQMKSGKWYLEDKEYWLQKVEDF 1074 D S +I +E+ ALY +SL+ I ++DY + +EYWL+ + Sbjct: 2834 DGVSTDIFIQELGALYEGKSLK--PFHIQYKDYAEWENSHARSEELKRQEEYWLKTYKG- 2890 Query: 1075 PLAPGLPLLTQPQHVKNPYFKRK-----SKHYSQQHWRQLKQISQNHNLTPSAVLCTVYA 1129 +P+L P K P K + + +R+L+ +++ + +T +L Y Sbjct: 2891 ----DIPVLDLPIDHKRPLTKSSEGDTVTAAIESETFRKLQHMAKENGVTMYMLLLAGYT 2946 Query: 1130 EVLANWSNQPQFGLNLTLFNRLPLHSDVDKLIGDFTSLLLLEVRMNPNDSFWEKAGNIQR 1189 +L+ ++ Q + R H D+ LIG F + L + +F + ++ Sbjct: 2947 ALLSKYTGQEDIIVGTPAAGR--NHEDIQHLIGMFVNTLAIRNHPEGKKTFRDYLQEVKE 3004 Query: 1190 VLMEALAHRHFDGIDVMREISKRRALGNKALLPIVFTSALFDNGEDGGEAAENHGEASDG 1249 ++A ++ + +++ +++ +R + P+ T ++ N + AE G S Sbjct: 3005 NTLQAYENQDYPFEELVEKVNIKRDMARN---PLFDTMLVYHNTDVKPFEAE--GLRSRL 3059 Query: 1250 EQSTNGITQTSQVYLDNQVALIHGKMVINWDYISELFDPAVMDAMFAQYLSRIEAILYSR 1309 + GI++ ++ A + + +Y + LF+ M+ + +S +E Sbjct: 3060 VEIKRGISKFDITVTASEAA---DGLRLEVEYSTTLFNKERMERLSEHLISLLEQAA-DH 3115 Query: 1310 EEMGFPAL----PASDYTSIQAYNHTEEPIPSK-TLHGLFEEAVHQTPYAVAIEADNLSI 1364 ++ + + + +N T+ + T+ LFE+ +TP A+ + +I Sbjct: 3116 PDIAINQIDVLTKGERHRVLYDFNRTDGVFCKEMTIPELFEKQAEKTPDHPAVAFGDETI 3175 Query: 1365 TYKELDDRADKVAGSLRSLGVSAGDRVGVIARKEIATFINILGILKSGAAYVPIDPEYPQ 1424 +Y+EL++RA+ +A +LR GV G++ + I + I+GILK+G AY+PIDP YPQ Sbjct: 3176 SYRELNERANSLAFTLRQKGVGPDVIAGILTERSIEMIVGIMGILKAGGAYLPIDPAYPQ 3235 Query: 1425 ERVDYIRNHSQCKLVLET-----------DYYEKNCRGQ--HPAELQRHNLPESLAYVIY 1471 ER+ YI S ++ D + GQ H L+ P+ LAYVIY Sbjct: 3236 ERISYIVKDSDVSVLCAAGDVDPGEAYTGDIIRIDQTGQNDHVENLKHDIKPQHLAYVIY 3295 Query: 1472 TSGSTGNPKGVMISHQAACNTVQDINQKF--QVGAADRMLGISSLCFDLSVYDIFGAFAA 1529 TSGSTG PKGVMI H + N V +N++ + A + ++ FD SV IF A Sbjct: 3296 TSGSTGKPKGVMIEHHSVNNLVHGLNERIYQHLDAHLNVALVAPYIFDASVKQIFAALLF 3355 Query: 1530 GATLVLVKDQK--DIRQLADTLSAQKITIWNSVPAIMDRVGSEIRAQGIYQENLDLRLVL 1587 G TL +V + D L + S I + + PA ++ + + + D++ ++ Sbjct: 3356 GHTLCIVPRETAWDAMSLIEYYSKNNINVSDMTPAHLNMLAYVDKT----ELEFDVKELI 3411 Query: 1588 LSGDWIPLHLPETVKQLFPAAKLISCG-----GATEASIWSIYYPIDE-VMPQWTSIPYG 1641 + GD + P+ + LF +SC G TE + + + I+ +PQ SIP G Sbjct: 3412 VGGDALT---PDVIGGLFHKFPNLSCNITNVYGPTECCVDAASHQIESGKVPQTPSIPIG 3468 Query: 1642 MPLANQQFYVLNQQMDYCPLEVSGELYIGGSGVANGYLNDPEKPSHSFIHHP-ELG-YIY 1699 PL N Y++++++ P+ ++GEL I G GVA GY+N PE + F+ HP E G +Y Sbjct: 3469 RPLLNTSIYIVDKELRPLPVGIAGELCIAGEGVARGYVNRPELTAEKFVDHPFEPGKKMY 3528 Query: 1700 RTGDYGVLHRDGCIEFLGRKDQQVKVGGYRIELGEVEAQLLRCGGVRHAVVLAADGEDKR 1759 +TGD + DG IEFLGR D QVK+ GYRIELGEVE QLL ++ A V+A G+D+ Sbjct: 3529 KTGDLAMWLPDGQIEFLGRADHQVKIRGYRIELGEVEQQLLTHEKIKEAAVIA--GKDQN 3586 Query: 1760 LGAYLIPDSQSADQAAFINEVRARIAKVLPDYMIPHYFVVLEQFPLTANGKMDVQALLKL 1819 +YL ++D+ +VR + + +PDYMIP YFV L++ P T +GK+D AL + Sbjct: 3587 GNSYLCA-YIASDKELPAADVRQFLEREMPDYMIPSYFVKLDRLPRTPSGKVDRSALPEA 3645 Query: 1820 QPAGN-KQTSAYTAPRNDVEERIVNIFKELLEADQVGTLDNFFEMGINSVQIAMINNKLK 1878 N + + Y PRN++E ++V +++E+L A+ +G +FF G +S++ I ++L Sbjct: 3646 DGNVNVMEGTGYDPPRNEIERKLVQVWREILGAEDIGISHHFFAAGGDSIKALQIVSRLA 3705 Query: 1879 QEFQKEIPLLTLFEYANIHALAGYLSGNDQNEPDDVP 1915 + ++ + LF I L+ +++ ++ + P Sbjct: 3706 K-MNLKLEMKALFANPKIKDLSRFITEETRHRKHNKP 3741 Score = 669 bits (1726), Expect = 0.0, Method: Compositional matrix adjust. Identities = 522/1945 (26%), Positives = 899/1945 (46%), Gaps = 142/1945 (7%) Query: 14 YWLETF-----SGEIPLLHLPADHSRPAFKTYRGSAEMFSIPKEQVLEIKQLAAEQEATL 68 YWL+ + E+PL PA ++P+FK + + + E+K+ A T Sbjct: 822 YWLDKLDHFPSAPELPLKSDPAHVAKPSFKKFSTFLDGHTWN-----ELKKKARHHHLTP 876 Query: 69 YMVLFAVWNILLAKLSDQEEIIVGVPTSGR--NHSDIEHVIGMFVNTLPIKSRISAKLT- 125 VL A + +LA S Q + + R H D++++IG F + + + ++ Sbjct: 877 TSVLCAAYAYILAYWSRQNHFAINLTVFNRIPFHPDVKNMIGDFTSLMLLDIHAEENMSS 936 Query: 126 FAEILHAMKANISNALEHQDYPFEDLVSQLQITRDFGRNPLFDVMFXXXXXXXXXXXXXX 185 F ++ + ALEH+ Y D++ + + + ++F Sbjct: 937 FWRFALNVQDTLLEALEHRHYDGVDVIRNIAKKNGMNKKAVMPIVFTSVLSENPDDSFDS 996 Query: 186 XXXXELQMKPYPYTTTTSRFDLTLDGEERAGELVFTLEYATDLFTRETVMRLIRYFRTIL 245 + + ++T TS+ + E G L T +Y +F E + + + ++ Sbjct: 997 LVDFD---NIHFFSTRTSQVYIDNQVYEINGGLYITWDYVEQIFEHEVIESMFDQYIAVI 1053 Query: 246 LEVLKHPAQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVT 305 + + + I + N+++ ++++ +N T + + +H+LF +VK P + A+ Sbjct: 1054 QKAVS--GEDVSTIQM--NEKSRQMISAYNDTDQSF-DAKPLHELFTGQVKHGPDRMALK 1108 Query: 306 FRNQSITYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPI 365 ++ +TY EL+ G+ + +I RS+ P+ Sbjct: 1109 HHDEVMTYQELDEKSNQVARFLIGKGVEKGDYIGVIGKRSLGTIVNLLAVLKTGAAYIPL 1168 Query: 366 DPGLPANRIAYMLDDAGVQVILTNTSVENQGNRIVLDMRSLGLDHGAPLPVPPVHSSRNL 425 DP P R AY+ + + +++ + + ++ + PV ++ Sbjct: 1169 DPDYPEERKAYIQSKSNCKFFISHDVYDKEH-----------IERFSKAPVDRKVDLDDM 1217 Query: 426 AYCMYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESILP 485 AY ++TSG+TG PKG+ + H N I++ + + + + ++++ FD+ + Sbjct: 1218 AYVIFTSGSTGKPKGVQITHVPQRNTILDINEKFNVTEQDNIMGISSLCFDLSVYDVFGA 1277 Query: 486 LLAGYQLVIADELQQKDVHALLALVKQAEISVMQTTPSRXXXXXXXXXXXXXXXXXRYLL 545 L +G LVI D+ Q+DV +L ++ I++ + P+ R +L Sbjct: 1278 LSSGASLVIIDD--QRDVFSLKETAEKERITIWNSVPAIMGMTADVYPDNELNHHLRLIL 1335 Query: 546 IGGEPLPQALAEQARSILPGGRIFNLYGPTETTIWST---AQEVTAGPVNI--GKPLKNT 600 + G+ +P L + + +L G TE +IWS Q+V +I GKPL N Sbjct: 1336 LSGDWIPLQLPATIKKTFKNAEVISLGGATEGSIWSIYYPIQKVEEDWKSIPYGKPLANQ 1395 Query: 601 QVYILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGDIA 660 ++Y+LN L P+GV G LYIGG GV GY ++ E T FI ++ IY TGD Sbjct: 1396 KIYVLNQNKQLCPVGVEGELYIGGAGVASGYIHDQEKTEHSFIQ--HQELGYIYKTGDYG 1453 Query: 661 RWTEEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLVAY 720 E+G +E+LGR D QVKIRGYR+E+ EIE L +H I K+ V L A+ Sbjct: 1454 VLKEDGYVEFLGRKDSQVKIRGYRVEMGEIENTLVSHQEITKASVIDYTSPDGIKNLYAF 1513 Query: 721 YTAARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPV----TVTLV 776 A +S +++EFL K LP YMIP F++I +IPL ++GK+D + L + T Sbjct: 1514 VVAENAISQLDVKEFLQKTLPDYMIPAKFVQIEEIPLTVNGKVDKRTLHDLAEQHTADEG 1573 Query: 777 QPGETRKPQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINKCFPVSF 836 Q G P++E + LLEIWK + + + ++E+GG+S++ + ++ EINK V Sbjct: 1574 QRGGRMLPENETQAMLLEIWKDIFGLDSINLDVSYYEIGGDSLKAISIITEINKRMNVEM 1633 Query: 837 QFTHFIERQTIERIADFIKEAIQEERKEELPFIAADPANRHEPFPLTNVQMAYYLGRSSH 896 + + TI + ++K +EE E P A E +P + Q Y+ Sbjct: 1634 PISEIFKNDTIIALDHYLKN--REESDMEHPI---QKAREKEYYPTSPAQQRMYMLSMLE 1688 Query: 897 FELGGVSTHSYLEMATELDIRRLNQCLNTLIQRHPALHT---VYLPDATQQILPEVPEYT 953 E G L + ++ +L L T +QRH L T + + Q+I V Sbjct: 1689 NERGAYHIPMALLVEGRINAMQLENALKTFLQRHEILRTGFEIQNNELIQKIYENVDFRL 1748 Query: 954 ICEYDLSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAFRSSPEESLLCISFDLLI 1013 E + T++ IT + S F+ + PL + +L I+F +I Sbjct: 1749 EYECLDASITDQHALMEITSRYCKESIKPFDLSRPPLMRAKLIKIDDIRHILVINFHHII 1808 Query: 1014 MDAYSLEILQEEIMALYADRSLQLEELSITFRDYLVGYQQMKSGKWYLEDKEYWLQKVED 1073 D S IL EI+ LY++ + L E+++ ++DY+ + + YWL D Sbjct: 1809 SDGVSQGILMNEILELYSN--VPLPEVNVQYKDYVEWNHTFNQSAAMKKQEAYWLDVYRD 1866 Query: 1074 FPLAPGLPLLTQPQHVKNPYFKRKSKHYSQQHWRQLKQISQNHNLTPSAVLCTVYAEVLA 1133 P P + H+ ++ ++++++++ T V+ + Y +L Sbjct: 1867 IPSKLDFPYDYKRHHIDTFEGSSVFLEMERELSDHIRKLAKHNGTTLYTVMLSAYYVLLN 1926 Query: 1134 NWSNQPQFGLNLTLFNRLPLHSDVDKLIGDFTSLLLLEVRMNPNDSFWEKAGNIQRVLME 1193 ++NQ + R LH D+ + G F + L L ++ + SF E + + Sbjct: 1927 KYTNQTDIVVGTAAAGR--LHPDLQDVFGVFVNTLALRNEVDTSYSFKEFLQQTKERTIA 1984 Query: 1194 ALAHRHFDGIDVMREISKRRALGNKALLPIVFTSALFDNGEDGGEAAENHGEASDGEQST 1253 A + + D++R+++ R L +F ED + G+ + + Sbjct: 1985 AFDNSEYPFDDLIRKLNGVRESNRNPLFDTMFVL------EDARMFTKQKGDV----KLS 2034 Query: 1254 NGITQTSQVYLDN--QVALIHGKMVINWDYISELFDPAVMDAMFAQYLSRIEAI------ 1305 I + D V K+V+N +Y + LF + + Y +E + Sbjct: 2035 PIIFELDNAKFDMIFNVLDFEQKIVLNIEYSTSLFKDETIQKIAEDYFRILEEVSENLDV 2094 Query: 1306 ------LYSREEMGFPALPASDYTSIQAYNHTEEPIPS-KTLHGLFEEAVHQTPYAVAIE 1358 + SR+E T ++++NHT+ P K +H LFEE + P A+ Sbjct: 2095 ALHQIDMISRQE---------KRTLLESFNHTKTAYPKGKAIHQLFEEQAKRIPDHTAVV 2145 Query: 1359 ADNLSITYKELDDRADKVAGSLRSLGVSAGDRVGVIARKEIATFINILGILKSGAAYVPI 1418 ++ +TY++L+++A++VA LR GV VG++ + ILG+LK+G AY+PI Sbjct: 2146 FEDQKLTYRQLNEKANQVARLLREKGVKPDTLVGIMMERSSDMIAAILGVLKAGGAYLPI 2205 Query: 1419 DPEYPQERVDYIRNHSQCKLVLE---------------TDYYEKNCRGQHPAELQRHNLP 1463 DPEYP ER+ Y+ S+ K+++ ++ GQ +++ N Sbjct: 2206 DPEYPPERMRYMAFDSEVKVIISDVPLAEELTAESIELIHMDDERIAGQDRSDIDNVNQS 2265 Query: 1464 ESLAYVIYTSGSTGNPKGVMISHQAACNTVQDINQKFQVGAADRMLGISSLCFDLSVYDI 1523 LAYVIYTSGSTG PKGVMI HQ+ N F+VG D +S+ FD V+++ Sbjct: 2266 GDLAYVIYTSGSTGKPKGVMIEHQSLINLCSWHQSCFEVGQNDNSSIYASISFDAFVWEL 2325 Query: 1524 FGAFAAGATLVLVKDQK--DIRQLADTLSAQKITIWNSVPAIMDRVGSEIRAQGIYQENL 1581 F AGAT+ ++ + D+ +L ITI + +P + + Q +N Sbjct: 2326 FPYITAGATVHVLNQETRLDVEKLNRYFHDHHITI-SFLP-------TPVCEQFTALDNH 2377 Query: 1582 DLRLVLLSGDWIPLHLPETVKQLFPAAKLISCGGATEASIWSIYYPIDEVMPQWTSIPYG 1641 LR +L GD + + ++ ++++ G TE ++ + +PID+ +IP G Sbjct: 2378 SLRTLLTGGDKLNVFKEKSY-------QIVNNYGPTENTVVATSFPIDK---SHQNIPIG 2427 Query: 1642 MPLANQQFYVLNQQMDYCPLEVSGELYIGGSGVANGYLNDPEKPSHSFIHHPEL--GYIY 1699 P+ N + Y+LN+ + CPL SGEL I G G+A GY+N PE FI +P + +Y Sbjct: 2428 KPIDNVKVYILNKDLQLCPLGASGELCIAGEGLARGYVNRPELTREKFIGNPFVPGERMY 2487 Query: 1700 RTGDYGVLHRDGCIEFLGRKDQQVKVGGYRIELGEVEAQLLRCGGVRHAVVLA-ADGE-D 1757 RTGD + DG I+FLGR DQQVK+ GYRIE GE+E +LL+ + A V+A DG+ D Sbjct: 2488 RTGDLAKMLPDGNIQFLGRVDQQVKIRGYRIEPGEIENRLLKYEKIEEAAVIAREDGDHD 2547 Query: 1758 KRLGAYLIPDSQSADQAAFINEVRARIAKVLPDYMIPHYFVVLEQFPLTANGKMDVQALL 1817 L AY+ + + ++RA + K LPDYMIP YFV L+ PLT NGK+D ++L Sbjct: 2548 PYLCAYVTVKKEVEPE-----KIRAFLKKSLPDYMIPQYFVQLDGLPLTVNGKVDKKSL- 2601 Query: 1818 KLQPAGNKQTSA---YTAPRNDVEERIVNIFKELLEADQVGTLDNFFEMGINSVQIAMIN 1874 P + + Y APR+ +EE++V+I++E L +++G +FFE G +S++ A + Sbjct: 2602 ---PVPERSVTMDRRYEAPRDQMEEKLVSIWEEALGINKIGINSHFFEAGGHSLKAAALV 2658 Query: 1875 NKLKQEFQKEIPLLTLFEYANIHAL 1899 + + +E ++PL +FE I L Sbjct: 2659 STIHKELNVKLPLRQIFETPTIKGL 2683 Score = 426 bits (1094), Expect = e-116, Method: Compositional matrix adjust. Identities = 267/867 (30%), Positives = 440/867 (50%), Gaps = 26/867 (2%) Query: 14 YWLETFSGEIPLLHLPADHSRPAFKTYRGSAEMFSIPKEQVLEIKQLAAEQEATLYMVLF 73 YW + G LPA + + Y G ++ S KE +I ++A + T+ VL Sbjct: 4398 YWKDYLKGYESRSELPAFNRGATSEEYCGKEKVISFSKELTTKITRIAKQHHVTINTVLQ 4457 Query: 74 AVWNILLAKLSDQEEIIVGVPTSGRNH--SDIEHVIGMFVNTLPIKSRISAKLTFAEILH 131 +W ++LAK + +E++ G SGR IE ++G+F++T+P + +F E+L Sbjct: 4458 GIWGMILAKYKNTDEVVFGTVVSGREAPVDGIEEMVGLFIHTIPTRISFEGARSFKEVLK 4517 Query: 132 AMKANISNALEHQDYPFEDLVSQLQITRDFGRNPLFDVMFXXXXXXXXXXXXXXXXXXEL 191 +A ++E Y + +L S++Q+ + R + VM Sbjct: 4518 KTQAE---SIESNRYSYMNL-SEIQVLSEMKRELITHVMAFQNYAFDEELFRSQSGETGF 4573 Query: 192 QMKPYPYTTTTSRFDLTLDGEERAGELVFTLEYATDLFTRETVMRLIRYFRTILLEVLKH 251 +++ + + ++ L G +L L + +++ + L ++ T+ +V + Sbjct: 4574 ELEGV-HGKERTNYNFNLTGVLEDEQLKLKLTFNENVYDNTIIETLEKHIITVAEQVAED 4632 Query: 252 PAQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVTFRNQSI 311 Q I+L +E R+L+ FN T YP+ +H+LF + + P A+ F Q + Sbjct: 4633 ETQTLRDINLVSKEEQHRILHTFNDTKTGYPKDKPLHELFEEQAMKTPDHTALVFGAQRM 4692 Query: 312 TYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPIDPGLPA 371 TY ELN GIG I A+I RS +M PIDP P Sbjct: 4693 TYRELNEKANQTARLLREKGIGRGSIAAIIADRSFEMIIGIIGILKAGGTYLPIDPETPR 4752 Query: 372 NRIAYMLDDAGVQVILTNTSVENQGNRIVLDMRSLGLDHGAPLPVPPVHSSRNLAYCMYT 431 +RI YML ++G +++T S+ + +D+ S L + +P V+ S + AY +YT Sbjct: 4753 DRIDYMLKNSGAALLVTTDSLLKPFDIKTVDLCSDELHLLSEENLPRVNRSSDTAYIVYT 4812 Query: 432 SGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESILPLLAGYQ 491 SG+TG PKG+++ H S ++ + + L L+ SFD + LL G Sbjct: 4813 SGSTGTPKGVVIPHYSAARVVKN-TNYIDITGNDVILQLSNYSFDGSVFDIFGALLNGAS 4871 Query: 492 LVIADELQQKDVHALLALVKQAEISVMQTTPSRXXXXXXXXXXXXXXXXXRYLLIGGEPL 551 LV+ ++ + H L ++K+ ++SVM T + R +L GGE Sbjct: 4872 LVLIEKETVLNTHELAEVIKKEQVSVMFITTA--LFNTLADINIGCLAKLRKILFGGE-- 4927 Query: 552 PQALAEQARSILPG---GRIFNLYGPTETTIWSTAQEVT-----AGPVNIGKPLKNTQVY 603 +A R +L ++ ++YGPTE+T+++T + A + IG PL NT V Sbjct: 4928 -RASIPHVRKVLDHVGRDKLIHVYGPTESTVYATYYFINEIDDEAETIPIGSPLANTSVL 4986 Query: 604 ILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGDIARWT 663 I+++ L PIGVPG L I G G+ +GY N ELTA++FI +P+ PGE++Y TGD+A+W Sbjct: 4987 IMDEAGKLLPIGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFIPGERLYKTGDLAKWL 5046 Query: 664 EEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLVAYYTA 723 +G IE++GR D QVKIRG+RIEL EIE +L+ H I +++V + D++ P + AY TA Sbjct: 5047 PDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDEESRPYICAYITA 5106 Query: 724 ARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPVTVTLVQPGETRK 783 R +S EL+ FL + LP YMIP +F+++ K+PL +GK+D KALP + E Sbjct: 5107 NREISLDELKGFLGEKLPDYMIPAYFVKMDKLPLTKNGKVDRKALPEPDRSAGTEAEYEA 5166 Query: 784 PQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINKCFPVSFQFTHFIE 843 P++ VE++++ I + VL G+ FF+ GGNS++ MQ V+ INK F + + + F + Sbjct: 5167 PRNYVEQRIISILEDVLGTERMGISCHFFDKGGNSLKAMQAVHSINKTFGIDMRISTFFK 5226 Query: 844 RQTIERIADFI-----KEAIQEERKEE 865 T + +A F+ + A+ EE EE Sbjct: 5227 HPTAKSLARFVLTAEAESAVSEEYAEE 5253 Score = 377 bits (967), Expect = e-102, Method: Compositional matrix adjust. Identities = 291/1072 (27%), Positives = 515/1072 (48%), Gaps = 92/1072 (8%) Query: 880 FPLTNVQMAYYLGRSSHFELGGVSTHSYLEMATELDIRRLNQCLNTLIQRHPALHTVYLP 939 +PL N+Q + G +++ + L + + +++RH L + Sbjct: 4210 YPLANMQKGMLFHNAMDQTSGAYFQQIVIKLKGRVHPDILEESFHEIVKRHEILRASFEY 4269 Query: 940 DAT---QQILPEVPEYTICEYDLSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAF 996 + T +QI+ + DL+G +++ I F+ + L + Sbjct: 4270 EITAEPRQIIARDRKTPFTSIDLTGENRTRQHRFIETYLKEDQEKGFDLSSEALMRVCLI 4329 Query: 997 RSSPEESLLCISFDLLIMDAYSLEILQEEIMALYAD----RSLQLEELSITFRDYLVGYQ 1052 + S E L S +++D + L I+ E+ +LY S +L+E + DY+ Sbjct: 4330 KMSDESYRLIWSHHHILLDGWCLGIVLSELFSLYGKIMKGESRRLKEPK-PYGDYI---- 4384 Query: 1053 QMKSGKWY-LEDKE----YWLQKVEDFPLAPGLPLLTQPQHVKNPYFKRKSKHYSQQHWR 1107 KW +D+E YW ++ + LP + + K K +S++ Sbjct: 4385 -----KWLEKQDQEEAVAYWKDYLKGYESRSELPAFNRGATSEEYCGKEKVISFSKELTT 4439 Query: 1108 QLKQISQNHNLTPSAVLCTVYAEVLANWSNQPQFGLNLTLFNRLPLHSDVDKLIGDFTSL 1167 ++ +I++ H++T + VL ++ +LA + N + + R +++++G F Sbjct: 4440 KITRIAKQHHVTINTVLQGIWGMILAKYKNTDEVVFGTVVSGREAPVDGIEEMVGLFIHT 4499 Query: 1168 LLLEVRMNPNDSFWEKAGNIQRVLMEA--LAHRHFDGIDVMREISKRRALGNKALLPIVF 1225 + + SF E Q +E+ ++ + I V+ E+ + A F Sbjct: 4500 IPTRISFEGARSFKEVLKKTQAESIESNRYSYMNLSEIQVLSEMKRELITHVMAFQNYAF 4559 Query: 1226 TSALF--DNGEDGGEAAENHGEASDGEQSTNGITQTSQVYLDNQVALIHGKMVINWDYIS 1283 LF +GE G E E G++ TN + V D Q+ L K+ N Sbjct: 4560 DEELFRSQSGETGFEL-----EGVHGKERTNYNFNLTGVLEDEQLKL---KLTFN----E 4607 Query: 1284 ELFDPAVMDAMFAQYLSRIEAI------------LYSREEMGFPALPASDYTSIQAYNHT 1331 ++D +++ + ++ E + L S+EE + + +N T Sbjct: 4608 NVYDNTIIETLEKHIITVAEQVAEDETQTLRDINLVSKEEQ---------HRILHTFNDT 4658 Query: 1332 EEPIPS-KTLHGLFEEAVHQTPYAVAIEADNLSITYKELDDRADKVAGSLRSLGVSAGDR 1390 + P K LH LFEE +TP A+ +TY+EL+++A++ A LR G+ G Sbjct: 4659 KTGYPKDKPLHELFEEQAMKTPDHTALVFGAQRMTYRELNEKANQTARLLREKGIGRGSI 4718 Query: 1391 VGVIARKEIATFINILGILKSGAAYVPIDPEYPQERVDYIRNHSQCKLVLETDYYEKN-- 1448 +IA + I I+GILK+G Y+PIDPE P++R+DY+ +S L++ TD K Sbjct: 4719 AAIIADRSFEMIIGIIGILKAGGTYLPIDPETPRDRIDYMLKNSGAALLVTTDSLLKPFD 4778 Query: 1449 ------CRGQ----HPAELQRHNLPESLAYVIYTSGSTGNPKGVMISHQAACNTVQDINQ 1498 C + L R N AY++YTSGSTG PKGV+I H +A V++ N Sbjct: 4779 IKTVDLCSDELHLLSEENLPRVNRSSDTAYIVYTSGSTGTPKGVVIPHYSAARVVKNTNY 4838 Query: 1499 KFQVGAADRMLGISSLCFDLSVYDIFGAFAAGATLVLVKDQK--DIRQLADTLSAQKITI 1556 + D +L +S+ FD SV+DIFGA GA+LVL++ + + +LA+ + +++++ Sbjct: 4839 -IDITGNDVILQLSNYSFDGSVFDIFGALLNGASLVLIEKETVLNTHELAEVIKKEQVSV 4897 Query: 1557 WNSVPAIMDRVGSEIRAQGIYQENLDLRLVLLSGDWIPLHLPETVKQLFPAAKLISCGGA 1616 A+ + + ++I + + LR +L G+ + V KLI G Sbjct: 4898 MFITTALFNTL-ADINIGCLAK----LRKILFGGERASIPHVRKVLDHVGRDKLIHVYGP 4952 Query: 1617 TEASIWSIYYPIDEVMPQWTSIPYGMPLANQQFYVLNQQMDYCPLEVSGELYIGGSGVAN 1676 TE+++++ YY I+E+ + +IP G PLAN ++++ P+ V GEL I G G++ Sbjct: 4953 TESTVYATYYFINEIDDEAETIPIGSPLANTSVLIMDEAGKLLPIGVPGELCIAGDGLSK 5012 Query: 1677 GYLNDPEKPSHSFIHHPEL--GYIYRTGDYGVLHRDGCIEFLGRKDQQVKVGGYRIELGE 1734 GYLN E + FI HP + +Y+TGD DG IEF+GR D QVK+ G+RIELGE Sbjct: 5013 GYLNREELTAEKFIPHPFIPGERLYKTGDLAKWLPDGNIEFIGRIDHQVKIRGFRIELGE 5072 Query: 1735 VEAQLLRCGGVRHAVVLAADGEDKR--LGAYLIPDSQSADQAAFINEVRARIAKVLPDYM 1792 +E++L + +V + E+ R + AY+ +A++ ++E++ + + LPDYM Sbjct: 5073 IESRLEMHEDINETIVTVREDEESRPYICAYI-----TANREISLDELKGFLGEKLPDYM 5127 Query: 1793 IPHYFVVLEQFPLTANGKMDVQALLKLQPAGNKQTSA-YTAPRNDVEERIVNIFKELLEA 1851 IP YFV +++ PLT NGK+D +AL +P + T A Y APRN VE+RI++I +++L Sbjct: 5128 IPAYFVKMDKLPLTKNGKVDRKAL--PEPDRSAGTEAEYEAPRNYVEQRIISILEDVLGT 5185 Query: 1852 DQVGTLDNFFEMGINSVQIAMINNKLKQEFQKEIPLLTLFEYANIHALAGYL 1903 +++G +FF+ G NS++ + + + F ++ + T F++ +LA ++ Sbjct: 5186 ERMGISCHFFDKGGNSLKAMQAVHSINKTFGIDMRISTFFKHPTAKSLARFV 5237 >C3IK59.1 C3IK59_BACTU AMP-binding enzyme Length = 2338 Score = 1269 bits (3283), Expect = 0.0, Method: Compositional matrix adjust. Identities = 724/1851 (39%), Positives = 1077/1851 (58%), Gaps = 96/1851 (5%) Query: 57 IKQLAAEQEATLYMVLFAVWNILLAKLSDQEEIIVGVPTSGRNHSDIEHVIGMFVNTLPI 116 I++++ Q+ L+ A + LA +DQE I +G+P +N E++ + +P+ Sbjct: 62 IQKISKSQDLLLFSWFQAALRVCLAHYTDQERITIGIPRIEKNLEQSENLNKL----IPL 117 Query: 117 KSRISAKLTFAEILHAMKANISNALEHQDYPFEDLVSQLQITRDFGRN----PLFDVMFX 172 S I H +PF+ LV++++ T FG PL +++ Sbjct: 118 GSEI----------------------HPHHPFKQLVNEIEQTTLFGYENQEYPLSELLVK 155 Query: 173 XXXXXXXXXXXXXXXXXELQMKPYPYTTTTSRFDLTLDGEERAGELVFTLEYATDLFTRE 232 E ++ Y + +L L + E+ E+ +R Sbjct: 156 HNLTPFQIVIGMEGLHNENSLEEY------AENNLALWIRRKWNEIHNEFEFQISCKSRS 209 Query: 233 --TVMRLIRYFRTILLEVLKHP--AQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVH 288 ++ + + +L +V ++P A K I + +E LN F QT + + + Sbjct: 210 FSSLQQFANSYCYVLKQVSQNPNLALKDICIIAEEEKELLEGLNTF-QTGIDLFQ--SFQ 266 Query: 289 QLFAARVKEHPHQAAVTFRNQSITYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDM 348 LF A+V + P Q AV +QS+TY ELN G+ + I+ ++ RS++M Sbjct: 267 DLFEAQVLKTPDQIAVVCNDQSLTYRELNKKANQLASILQSKGVSKESIIGVMVDRSLEM 326 Query: 349 XXXXXXXXXXXXXXXPIDPGLPANRIAYMLDDAGVQVILTNTSVEN----QGNRIVLDMR 404 PIDP P RI YML D+ + +L+ + E G + LD Sbjct: 327 IIGMMGILKAGAAYLPIDPNYPTERIEYMLQDSQAKYLLSKRTEEVLPQFAGEVLYLDKE 386 Query: 405 SLGLDHGAPLPVPPVHSSRNLAYCMYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKG 464 L G + H+ +LAY +YTSG+TG PKG+++E +SL++F + + + + Sbjct: 387 YLF--QGEESNLVREHNPNDLAYVIYTSGSTGNPKGVMIEQKSLVHFLNVMREKVK--AN 442 Query: 465 ETFLSLTTVSFDIFWLESILPLLAGYQLVIADELQQKDVHALLALVKQAEISVMQTTPSR 524 ++FL L +VSFDI LE LPL G ++VIA E +Q L LVK+ ++ + ++TPSR Sbjct: 443 QSFLFLASVSFDISLLEICLPLTQGSKVVIATE-EQFATKELAHLVKKHKVDLWESTPSR 501 Query: 525 XXXXXXXXXXXXXXXXXRYLLIGGEPLPQALAEQARSILPGGRIFNLYGPTETTIWSTAQ 584 + +L+ GE L E+ R I I N+YGPTETTI +T + Sbjct: 502 MEVILSDPEGANFLKDLKSILLAGEAFSIDLVEKIRCI-SEATILNIYGPTETTICATVK 560 Query: 585 EV-TAGPVNIGKPLKNTQVYILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFI 643 ++ T+ V IGKP N YILN L+P G+PG L I G V RGY +LT ++F+ Sbjct: 561 DLSTSKEVTIGKPNPNYHSYILNKYGQLKPFGIPGELCIAGVAVARGYLGKSKLTDEKFV 620 Query: 644 DNPYRPGEQIYCTGDIARWTEEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKS 703 +P+ GE +Y TGD+ RW G +EYLGR D QVKIRGYRIEL EIE QL +P I ++ Sbjct: 621 QSPFAAGEMMYHTGDLVRWLPNGELEYLGRMDHQVKIRGYRIELREIETQLREYPEINQA 680 Query: 704 VVRAQRDDQDEPMLVAYYTAARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKL 763 +V Q + +L AYY + VS E+R++L LP +MIP+ +++ +IPL +GK+ Sbjct: 681 IVVDQVYG-NRKLLAAYYVSDNKVSFGEIRKYLSDKLPEFMIPEKMIQVEEIPLNPNGKV 739 Query: 764 DVKALPPVTVTLVQPGETRKPQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQ 823 D K L +T T P++E+E+KL+ W+KV+ I G+ D FF + G SI+ +Q Sbjct: 740 DRKRLLDITQTDYVSIPYVAPRNEIEQKLVRAWEKVMEIEGIGIHDNFFALKGESIKALQ 799 Query: 824 LVYEINK-CFPVSFQFTHFIERQTIERIADFIKEAIQEERKEELPFIAADPANRHEPFPL 882 ++ + K C +S T F + TI +++ +K +EE E P D +N PF L Sbjct: 800 VINLLRKDCLKIST--TDFFKHPTIAQLSSCVKLEHKEENFESKPTHVKDLSN---PFSL 854 Query: 883 TNVQMAYYLGRSSHFELGGVSTHSYLEMATELDIRRLNQCLNTLIQRHPALHTVYLPDAT 942 T VQ AY LGR+S FEL G+S +Y E T LDI RL++ +I RHP L V LP+ Sbjct: 855 TEVQTAYMLGRNSQFELSGISPQTYFEYETALDINRLSKSFQKVIHRHPMLRAVILPEGK 914 Query: 943 QQILPEVPEYTICEYDLSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAFRSSPEE 1002 QQIL VP+Y I L + ++ R+ +ER RM++H+F WPLFE+ AF + Sbjct: 915 QQILQSVPDYEIEIESLIDLDDRNQHARLQEERSRMTNHVFPLGQWPLFELKAFLLKEDT 974 Query: 1003 SLLCISFDLLIMDAYSLEILQEEIMALYADRSLQLEELSITFRDYLVGYQQMKSGKWYLE 1062 LLC +D L+MD S+ I+ ++++ Y + +LE LS F+DY+ Y +MK Y Sbjct: 975 YLLCFRYDALLMDGASMNIVGQDLLHYYYKPNQKLESLSFDFQDYMFIYDEMKQIGEYKT 1034 Query: 1063 DKEYWLQKVEDFPLAPGLPLLTQPQHVKNPYFKRKSKHYSQQHWRQLKQISQNHNLTPSA 1122 K+YW K+ DFP AP L L P + P F+ +K + W +L++++Q +TPSA Sbjct: 1035 AKDYWTSKLPDFPFAPSLLLKKDPAEIATPKFQSLTKILDNEKWTKLRKLAQEKEVTPSA 1094 Query: 1123 VLCTVYAEVLANWSNQPQFGLNLTLFNRLPLHSDVDKLIGDFTSLLLLEVRMNPNDSFWE 1182 +LCT+Y +VLA WSNQ + +NLT+FNR P+H +V++++GDFTSL+LL+V + P +F+ Sbjct: 1095 LLCTIYGDVLAYWSNQRRLAINLTVFNRYPVHDEVEQIVGDFTSLILLDVDVKPEQTFFT 1154 Query: 1183 KAGNIQRVLMEALAHRHFDGIDVMREISKRRALGNKALLPIVFTSALFDNG----EDGGE 1238 + Q L++ L HRH+DG++ +R+ ++ + KA++PIVFTS L G E G Sbjct: 1155 RVKETQSTLLDGLEHRHYDGVNFIRDFTRYHQMTPKAVMPIVFTSMLAGAGAFSWEQLGS 1214 Query: 1239 AAENHGEASDGEQSTNGITQTSQVYLDNQVALIHGKMVINWDYISELFDPAVMDAMFAQY 1298 H +T QVYLDN V +G+++I+W+Y+ ELFD V++AMF+Q+ Sbjct: 1215 LRYIHA-------------RTPQVYLDNVVIEKNGELLISWNYVEELFDIDVIEAMFSQF 1261 Query: 1299 LSRIEAILYSREEMGFPALPASDYTSIQAYNHTEEPIPSKTLHGLFEEAVHQTPYAVAIE 1358 + +E L + ++ + SD T I+ YN T E IPS TL+ LF + V +TP VA+ Sbjct: 1262 VDLLEQ-LVKQSDITSLQMKESDQTLIEQYNETTEKIPSTTLYQLFTDQVKRTPNEVAVV 1320 Query: 1359 ADNLSITYKELDDRADKVAGSLRSLGVSAGDRVGVIARKEIATFINILGILKSGAAYVPI 1418 + +TY EL R++++A L+ G+ GD+VG++A++ + T +N+LGILK+GAAYVPI Sbjct: 1321 FEQKWLTYSELHKRSNQIAHFLKEQGIGLGDKVGLLAKRRVDTIVNMLGILKAGAAYVPI 1380 Query: 1419 DPEYPQERVDYIRNHSQCKLVLETDYYEKNCRGQHPAE-LQRHNLPESLAYVIYTSGSTG 1477 DP +P +R YI +S CKL+LE YE+N + E + PE +AY+IYTSGSTG Sbjct: 1381 DPNHPLDRQTYILKNSSCKLLLEPSLYEENDLSFYTTEDMPAIAGPEDIAYIIYTSGSTG 1440 Query: 1478 NPKGVMISHQAACNTVQDINQKFQVGAADRMLGISSLCFDLSVYDIFGAFAAGATLVLVK 1537 PKGV+I+HQA NT+QDINQK++V DR++GISS+CFDLSVYDIFGA + GA LV+++ Sbjct: 1441 KPKGVIITHQAVTNTIQDINQKYEVNEDDRIIGISSMCFDLSVYDIFGALSTGAMLVMIR 1500 Query: 1538 DQKDIRQLADTLSAQKITIWNSVPAIMDRVGSEIRAQGIYQENLDLRLVLLSGDWIPLHL 1597 D +D+++L T+ + ITIWN+VPAIMD ++ G + E+ LRLVL SGDWIPL L Sbjct: 1501 DPRDMQELIRTVERRGITIWNTVPAIMDLALDQV---GSHFEHSSLRLVLHSGDWIPLSL 1557 Query: 1598 PETVKQLFPAAKLISCGGATEASIWSIYYPIDEVMPQWTSIPYGMPLANQQFYVLNQQMD 1657 PE +K+ FP A+++S GGATEASIWSIYYP+ +V W SIPYGMPLANQ +YVLN + Sbjct: 1558 PEKIKRHFPIAEVVSLGGATEASIWSIYYPVKQVESHWNSIPYGMPLANQTYYVLNYEKK 1617 Query: 1658 YCPLEVSGELYIGGSGVANGYLNDPEKPSHSFIHHPELGYIYRTGDYGVLHRDGCIEFLG 1717 CP+ V G+LYIGG G+A GYLND +K + +F+ HP+ G IY+TGD G +H +G IEFLG Sbjct: 1618 MCPVGVIGDLYIGGVGLAKGYLNDEKKTNEAFVSHPDFGLIYKTGDCGKMHSEGYIEFLG 1677 Query: 1718 RKDQQVKVGGYRIELGEVEAQLLRCGGVRHAVVLAADGED--KRLGAYLIPDSQSADQAA 1775 R+D QVK+ GYR+EL E+ LL V HAVV+ E+ K L AY++ +Q Sbjct: 1678 RQDYQVKIQGYRVELEEIAHCLLTYKQVEHAVVIDQTDENGIKFLVAYVV-----TEQNI 1732 Query: 1776 FINEVRARIAKVLPDYMIPHYFVVLEQFPLTANGKMDVQALLKLQPAGNKQTS-AYTAPR 1834 E+R + LPDYMIP YFV L+Q PLT NGK+D +AL P KQT+ + AP+ Sbjct: 1733 STTELRKHLRDHLPDYMIPSYFVYLDQLPLTPNGKLDRKAL----PTPEKQTNEVFIAPK 1788 Query: 1835 NDVEERIVNIFKELLEADQVGTLDNFFEMGINSVQIAMINNKL-KQEFQKE 1884 ++E+ + +I++E+L+ DQVG D+FF +G +S++ ++ +L +Q F+ E Sbjct: 1789 TEMEKILTSIWQEVLKIDQVGVNDHFFALGGDSIKAIQVSVRLYRQGFELE 1839 Score = 345 bits (885), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 304/1251 (24%), Positives = 547/1251 (43%), Gaps = 121/1251 (9%) Query: 19 FSGEIPLLHLPADHSRPAFKTYRGSAEMFSIPKEQVLEIKQLAAEQEATLYMVLFAVWNI 78 F+ + L PA+ + P F++ + E+ ++++LA E+E T +L ++ Sbjct: 1048 FAPSLLLKKDPAEIATPKFQSLTKI-----LDNEKWTKLRKLAQEKEVTPSALLCTIYGD 1102 Query: 79 LLAKLSDQEEIIVGVPTSGRN--HSDIEHVIGMFVNTLPIKSRISAKLTFAEILHAMKAN 136 +LA S+Q + + + R H ++E ++G F + + + + + TF + ++ Sbjct: 1103 VLAYWSNQRRLAINLTVFNRYPVHDEVEQIVGDFTSLILLDVDVKPEQTFFTRVKETQST 1162 Query: 137 ISNALEHQDYPFEDLVSQLQITRDFGR------NPLFDVMFXXXXXXXXXXXXXXXXXXE 190 + + LEH+ Y + RDF R + ++F + Sbjct: 1163 LLDGLEHRHY------DGVNFIRDFTRYHQMTPKAVMPIVFTSMLAGAGAFSWE-----Q 1211 Query: 191 LQMKPYPYTTTTSRFDLTLDGE--ERAGELVFTLEYATDLFTRETVMRLIRYFRTILLEV 248 L Y + T + LD E+ GEL+ + Y +LF + + + F +L ++ Sbjct: 1212 LGSLRYIHARTPQVY---LDNVVIEKNGELLISWNYVEELFDIDVIEAMFSQFVDLLEQL 1268 Query: 249 LKHPAQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVTFRN 308 +K ++ + L + L+ ++N+T + P T++QLF +VK P++ AV F Sbjct: 1269 VK----QSDITSLQMKESDQTLIEQYNETTEKIPS-TTLYQLFTDQVKRTPNEVAVVFEQ 1323 Query: 309 QSITYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPIDPG 368 + +TY EL+ GIG V L+ R VD PIDP Sbjct: 1324 KWLTYSELHKRSNQIAHFLKEQGIGLGDKVGLLAKRRVDTIVNMLGILKAGAAYVPIDPN 1383 Query: 369 LPANRIAYMLDDAGVQVILTNTSVENQGNRIVLDMRSLGLDHGAPLPVPPVHSSRNLAYC 428 P +R Y+L ++ +++L + E L +P + ++AY Sbjct: 1384 HPLDRQTYILKNSSCKLLLEPSLYEEND-----------LSFYTTEDMPAIAGPEDIAYI 1432 Query: 429 MYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESILPLLA 488 +YTSG+TG PKG+++ H+++ N I+ + + + ++++ FD+ + L Sbjct: 1433 IYTSGSTGKPKGVIITHQAVTNTIQDINQKYEVNEDDRIIGISSMCFDLSVYDIFGALST 1492 Query: 489 GYQLVIADELQQKDVHALLALVKQAEISVMQTTPSRXXXXXXXXXXXXXXXXXRYLLIGG 548 G LV+ + +D+ L+ V++ I++ T P+ R +L G Sbjct: 1493 GAMLVMIRD--PRDMQELIRTVERRGITIWNTVPAIMDLALDQVGSHFEHSSLRLVLHSG 1550 Query: 549 EPLPQALAEQARSILPGGRIFNLYGPTETTIWSTAQEVTA-----GPVNIGKPLKNTQVY 603 + +P +L E+ + P + +L G TE +IWS V + G PL N Y Sbjct: 1551 DWIPLSLPEKIKRHFPIAEVVSLGGATEASIWSIYYPVKQVESHWNSIPYGMPLANQTYY 1610 Query: 604 ILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGDIARWT 663 +LN E + P+GV G LYIGG G+ +GY N+ + T + F+ +P IY TGD + Sbjct: 1611 VLNYEKKMCPVGVIGDLYIGGVGLAKGYLNDEKKTNEAFVSHP--DFGLIYKTGDCGKMH 1668 Query: 664 EEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLVAYYTA 723 EG IE+LGR D+QVKI+GYR+EL EI L T+ +E +VV Q D+ LVAY Sbjct: 1669 SEGYIEFLGRQDYQVKIQGYRVELEEIAHCLLTYKQVEHAVVIDQTDENGIKFLVAYVVT 1728 Query: 724 ARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPVTVTLVQPGETR- 782 + +S ELR+ L LP YMIP +F+ + ++PL +GKLD KALP Q E Sbjct: 1729 EQNISTTELRKHLRDHLPDYMIPSYFVYLDQLPLTPNGKLDRKALP---TPEKQTNEVFI 1785 Query: 783 KPQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINK-----------C 831 P+ E+E+ L IW++VL+I GV D FF +GG+SI+ +Q+ + + Sbjct: 1786 APKTEMEKILTSIWQEVLKIDQVGVNDHFFALGGDSIKAIQVSVRLYRQGFELEPKNLFS 1845 Query: 832 FPVSFQFTHFIER-------------------QTIERIADF-IKEAIQEERKEELPFIAA 871 FP+ F+++ T+ I D + + + +E++P I Sbjct: 1846 FPILRDMVQFVKKLDHFSSSQTNDVNIMNDNKATLLNIKDKQLNQQTLTKIQEKMPDIKI 1905 Query: 872 DPANRHEPFPLTNVQMAYYLGRSSHFELGGVSTHSYLEMATELDIRRLNQCLNTLIQRHP 931 + +PL Q Y ++ + + + ELDI+ QC L+ RH Sbjct: 1906 ERI-----YPLAPFQEVIYEHATNEPDTNAYFEQTIWVLEGELDIKLFIQCFQQLVDRHD 1960 Query: 932 ALHTVYLPDATQQILPEVPEYTICEYDLSGYTEEAKNKRITK-ERDRMSHHIFNPNVWPL 990 +L T+ + D +Q P + YD+ +E +TK E+ N N+ Sbjct: 1961 SLRTIIVQD--EQAKP----WQAVLYDVQINSEIKNLIEMTKQEQQEFLKQWMNENLSRG 2014 Query: 991 FE-------IVAFRSSPEESLLCISFDLLIMDAYSLEILQEEIMALYADRS------LQL 1037 F+ + F+ E + S L+ D +S+ IL +E+ LY + L + Sbjct: 2015 FKNDELMTRLCIFQLGNNEHKVIWSSHHLLCDGWSVSILIDELFQLYETTNAGTTAGLPI 2074 Query: 1038 EELSITFRDYLVGYQQMKSGKWYLEDKEYWLQKVEDFPLAPGLPLLTQPQHVKNPYFKRK 1097 + TF D+ + K+ + +W + + +P P + F Sbjct: 2075 VKPFETFIDWTLVQDHEKA-------RHFWRDYLSGYNQKISIPKKEVPSKSEGLNFTFM 2127 Query: 1098 SKHYSQQHWRQLKQISQNHNLTPSAVLCTVYAEVLANWSNQPQFGLNLTLFNRLPLHSDV 1157 + QL+ +N+T + L V+ +L ++ + L + R P + Sbjct: 2128 DLTLDKDLTNQLQTFVTKNNITMNTALLAVWGILLGKFNGTREVVLPNLVSVRPPEVEGI 2187 Query: 1158 DKLIGDFTSLLLLEVRMNPNDSFWEKAGNIQRVLMEALAHRHFDGIDVMRE 1208 + + G FT++L + + SF + +Q ++ + ++ +D+ ++ Sbjct: 2188 ESMFGLFTNVLPIRLAWTETQSFVDFLQKVQLETLKCNEYAYYSFVDIQKQ 2238 >B7IJF1.1 B7IJF1_BACC2 Bacitracin synthetase 1 EC=5.1.1.3 Length = 2338 Score = 1264 bits (3271), Expect = 0.0, Method: Compositional matrix adjust. Identities = 725/1873 (38%), Positives = 1083/1873 (57%), Gaps = 94/1873 (5%) Query: 57 IKQLAAEQEATLYMVLFAVWNILLAKLSDQEEIIVGVPTSGRNHSDIEHVIGMFVNTLPI 116 I++++ Q+ L+ A + LA +DQE I +G+P +N E++ + +P+ Sbjct: 62 IQKISKSQDLLLFSWFQAALRVCLAHYTDQERITIGIPIIEKNLEQSENLNKL----IPL 117 Query: 117 KSRISAKLTFAEILHAMKANISNALEHQDYPFEDLVSQLQITRDFGRN----PLFDVMFX 172 S I H +PF+ LV++++ T FG PL +++ Sbjct: 118 GSEI----------------------HPHHPFKQLVNEIEQTTLFGYENQEYPLSELLVK 155 Query: 173 XXXXXXXXXXXXXXXXXELQMKPYPYTTTTSRFDLTLDGEERAGELVFTLEYATDLFTRE 232 E ++ Y + +L L + E+ E+ +R Sbjct: 156 HNLTPFQIVIGMEGLHNENSLEEY------AENNLVLWIRRKWNEIHNEFEFQISCKSRS 209 Query: 233 --TVMRLIRYFRTILLEVLKHP--AQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVH 288 ++ + + +L +V ++P A K I + +E LN F QT + + + Sbjct: 210 FSSLQQFANSYCYVLKQVSQNPNLALKDICIIAEEEKELLEGLNTF-QTGIDLFQ--SFQ 266 Query: 289 QLFAARVKEHPHQAAVTFRNQSITYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDM 348 LF A+V + P Q AV +QS+TY ELN G+ + I+ ++ RS++M Sbjct: 267 DLFEAQVLKTPDQIAVVCNDQSLTYRELNKKANQLASILQSKGVSKESIIGVMVDRSLEM 326 Query: 349 XXXXXXXXXXXXXXXPIDPGLPANRIAYMLDDAGVQVILTNTSVE--NQGNRIVLDMRSL 406 PIDP P RI YML D+ + +L+ + E Q VL Sbjct: 327 IIGMMGILKAGAAYLPIDPNYPTERIEYMLQDSQAKYLLSKRTEEVLPQFAGEVLYFDKE 386 Query: 407 GLDHGAPLPVPPVHSSRNLAYCMYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGET 466 L G + H+ +LAY +YTSG+TG PKG+++E +SL++F + + + + ++ Sbjct: 387 YLFQGEESNLVREHNPNDLAYVIYTSGSTGNPKGVMIEQKSLVHFLNVMREKVK--ANQS 444 Query: 467 FLSLTTVSFDIFWLESILPLLAGYQLVIADELQQKDVHALLALVKQAEISVMQTTPSRXX 526 FL L +VSFDI LE LPL G ++VIA E +Q L LVK+ ++ + ++TPSR Sbjct: 445 FLFLASVSFDISLLEICLPLTQGSKVVIATE-EQFATKELAHLVKKHKVDLWESTPSRME 503 Query: 527 XXXXXXXXXXXXXXXRYLLIGGEPLPQALAEQARSILPGGRIFNLYGPTETTIWSTAQEV 586 + +L+ GE L E+ R I I N+YGPTETTI +T +++ Sbjct: 504 VILSDPEGANFLKDLKSILLAGEAFSIDLVEKIRCI-SEATILNIYGPTETTICATIKDL 562 Query: 587 -TAGPVNIGKPLKNTQVYILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDN 645 T+ V IGKP N YILN L+P G+PG L I G V RGY +LT ++F+ + Sbjct: 563 STSKEVTIGKPNPNYHSYILNKYGQLKPFGIPGELCIAGVAVARGYLGKSKLTDEKFVQS 622 Query: 646 PYRPGEQIYCTGDIARWTEEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVV 705 P+ GE +Y TGD+ RW G +EYLGR D QVKIRGYRIEL EIE QL +P I +++V Sbjct: 623 PFAAGEMMYHTGDLVRWLPNGELEYLGRMDHQVKIRGYRIELREIETQLREYPEINQAIV 682 Query: 706 RAQRDDQDEPMLVAYYTAARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDV 765 Q + +L AYY + VS E+R++L LP +MIP+ +++ +IPL +GK+D Sbjct: 683 VDQVYG-NRKLLAAYYVSDNKVSFGEIRKYLSDKLPEFMIPEKMIQVEEIPLNPNGKVDR 741 Query: 766 KALPPVTVTLVQPGETRKPQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLV 825 K L +T T P++E+E+KL+ W+KV+ I G+ D FF + G SI+ +Q++ Sbjct: 742 KRLLDITQTDYVSIPYVAPRNEIEQKLVRAWEKVMEIEGIGIHDNFFALKGESIKALQVI 801 Query: 826 YEINK-CFPVSFQFTHFIERQTIERIADFIKEAIQEERKEELPFIAADPANRHEPFPLTN 884 + K C +S T F + TI +++ +K +EE E P D +N PF LT Sbjct: 802 NLLRKDCLKIST--TDFFKHPTIAQLSSCVKLEHKEENFESKPTHVKDLSN---PFSLTE 856 Query: 885 VQMAYYLGRSSHFELGGVSTHSYLEMATELDIRRLNQCLNTLIQRHPALHTVYLPDATQQ 944 VQ AY LGR+S FEL G+S +Y E T LDI RL++ +I RHP L V LP+ QQ Sbjct: 857 VQTAYMLGRNSQFELSGISPQTYFEYETTLDINRLSKSFQKVIHRHPMLRAVILPEGKQQ 916 Query: 945 ILPEVPEYTICEYDLSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAFRSSPEESL 1004 IL VP+Y I L + +N R+ +ER RM++H+F WPLFE+ AF + L Sbjct: 917 ILQSVPDYQIEIVSLIDLDDRNQNARLQEERSRMTNHVFPLGQWPLFELKAFLLKEDTYL 976 Query: 1005 LCISFDLLIMDAYSLEILQEEIMALYADRSLQLEELSITFRDYLVGYQQMKSGKWYLEDK 1064 LC +D L+MD S+ I+ ++++ Y + +LE LS F+DY+ Y +M+ Y K Sbjct: 977 LCFRYDALLMDGASMNIVGQDLLHYYYKPNQKLESLSFDFQDYMFIYDEMEQIGEYKTAK 1036 Query: 1065 EYWLQKVEDFPLAPGLPLLTQPQHVKNPYFKRKSKHYSQQHWRQLKQISQNHNLTPSAVL 1124 +YW K+ DFP AP L L P + P F+ +K + W +L++++Q +TPSA+L Sbjct: 1037 DYWTSKLPDFPFAPSLLLKKDPAEIATPKFQSLTKILDNEKWTKLRKLAQEKEVTPSALL 1096 Query: 1125 CTVYAEVLANWSNQPQFGLNLTLFNRLPLHSDVDKLIGDFTSLLLLEVRMNPNDSFWEKA 1184 CT+Y +VLA WSNQ + +NLT+FNR P+H +V++++GDFTSL+LL+V + P +F+ + Sbjct: 1097 CTIYGDVLAYWSNQRRLAINLTVFNRYPVHDEVEQIVGDFTSLILLDVDVKPEQTFFTRV 1156 Query: 1185 GNIQRVLMEALAHRHFDGIDVMREISKRRALGNKALLPIVFTSALFDNG----EDGGEAA 1240 Q L++ L HRH+DG++ +R+ ++ + KA++PIVFTS L G E G Sbjct: 1157 KETQSTLLDGLEHRHYDGVNFIRDFTRYHQMTPKAVMPIVFTSMLAGAGAFSWEQLGSLR 1216 Query: 1241 ENHGEASDGEQSTNGITQTSQVYLDNQVALIHGKMVINWDYISELFDPAVMDAMFAQYLS 1300 H +T QVYLDN V +G+++I+W+Y+ ELFD V++AMF+Q++ Sbjct: 1217 YIHA-------------RTPQVYLDNVVIEKNGELLISWNYVEELFDIDVIEAMFSQFVD 1263 Query: 1301 RIEAILYSREEMGFPALPASDYTSIQAYNHTEEPIPSKTLHGLFEEAVHQTPYAVAIEAD 1360 +E L + ++ + SD T I+ YN T E IPS TL+ LF + V +TP VA+ + Sbjct: 1264 LLEQ-LVKQSDITSLQMKESDQTLIEQYNETTEKIPSTTLYQLFTDQVKRTPNEVAVVFE 1322 Query: 1361 NLSITYKELDDRADKVAGSLRSLGVSAGDRVGVIARKEIATFINILGILKSGAAYVPIDP 1420 +TY EL R++++A L+ G+ GD+VG++A++ + T +N+LGILK+GAAYVPIDP Sbjct: 1323 QKWLTYSELHKRSNQIAHFLKEQGIGLGDKVGLLAKRRVDTIVNMLGILKAGAAYVPIDP 1382 Query: 1421 EYPQERVDYIRNHSQCKLVLETDYYEKNCRGQHPAE-LQRHNLPESLAYVIYTSGSTGNP 1479 ++P +R YI +S CK +LE YE+N + E + PE +AY+IYTSGSTG P Sbjct: 1383 DHPLDRQTYILKNSSCKFLLEPSLYEENDLSFYTTEDMPAIAGPEDIAYIIYTSGSTGKP 1442 Query: 1480 KGVMISHQAACNTVQDINQKFQVGAADRMLGISSLCFDLSVYDIFGAFAAGATLVLVKDQ 1539 KGV+I+HQA NT+QDINQK++V DR++ ISS+CFDLSVYDIFGA + GA LV+++D Sbjct: 1443 KGVIITHQAVTNTIQDINQKYEVNEDDRIISISSMCFDLSVYDIFGALSTGAMLVMIRDL 1502 Query: 1540 KDIRQLADTLSAQKITIWNSVPAIMDRVGSEIRAQGIYQENLDLRLVLLSGDWIPLHLPE 1599 +D+++L T+ + ITIWN+VPAIMD ++ G + E+ LRLVL SGDWIPL LPE Sbjct: 1503 RDMQELIRTVERRGITIWNTVPAIMDLALDQV---GSHFEHSSLRLVLHSGDWIPLSLPE 1559 Query: 1600 TVKQLFPAAKLISCGGATEASIWSIYYPIDEVMPQWTSIPYGMPLANQQFYVLNQQMDYC 1659 +K+ FP A+++S GGATEASIWSIYYP+ +V W SIPYGMPLANQ +YVLN + C Sbjct: 1560 KIKRHFPIAEVVSLGGATEASIWSIYYPVKQVESHWNSIPYGMPLANQTYYVLNYEKKMC 1619 Query: 1660 PLEVSGELYIGGSGVANGYLNDPEKPSHSFIHHPELGYIYRTGDYGVLHRDGCIEFLGRK 1719 P+ V G+LYIGG G+A GYLND +K + +F+ HP+ G IY+TGD G +H +G IEFLGR+ Sbjct: 1620 PVGVIGDLYIGGVGLAKGYLNDEKKTNEAFVSHPDFGLIYKTGDCGKMHSEGYIEFLGRQ 1679 Query: 1720 DQQVKVGGYRIELGEVEAQLLRCGGVRHAVVLAADGED--KRLGAYLIPDSQSADQAAFI 1777 D QVK+ GYR+EL E+ LL V HAVV+ E+ K L AY++ +Q Sbjct: 1680 DYQVKIQGYRVELEEISHCLLTYKQVEHAVVIDQTDENGIKFLVAYVV-----TEQNIST 1734 Query: 1778 NEVRARIAKVLPDYMIPHYFVVLEQFPLTANGKMDVQALLKLQPAGNKQTS-AYTAPRND 1836 E+R + LPDYMIP YFV L+Q PLT NGK+D +AL P KQ + + AP+ + Sbjct: 1735 TELRKHLRDHLPDYMIPSYFVYLDQLPLTPNGKLDRKAL----PTPEKQKNEVFIAPKTE 1790 Query: 1837 VEERIVNIFKELLEADQVGTLDNFFEMGINSVQIAMINNKL-KQEFQKEIPLLTLFEYAN 1895 +E+ + +I++E+L+ DQVG D+FF +G +S++ ++ +L +Q F+ E LF + Sbjct: 1791 MEKILTSIWQEVLKIDQVGVNDHFFALGGDSIKAIQVSVRLYRQGFELEPK--NLFSFPI 1848 Query: 1896 IHALAGYLSGNDQ 1908 + + ++ DQ Sbjct: 1849 LRDMVQFVKKLDQ 1861 Score = 352 bits (904), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 305/1250 (24%), Positives = 544/1250 (43%), Gaps = 119/1250 (9%) Query: 19 FSGEIPLLHLPADHSRPAFKTYRGSAEMFSIPKEQVLEIKQLAAEQEATLYMVLFAVWNI 78 F+ + L PA+ + P F++ + E+ ++++LA E+E T +L ++ Sbjct: 1048 FAPSLLLKKDPAEIATPKFQSLTKI-----LDNEKWTKLRKLAQEKEVTPSALLCTIYGD 1102 Query: 79 LLAKLSDQEEIIVGVPTSGRN--HSDIEHVIGMFVNTLPIKSRISAKLTFAEILHAMKAN 136 +LA S+Q + + + R H ++E ++G F + + + + + TF + ++ Sbjct: 1103 VLAYWSNQRRLAINLTVFNRYPVHDEVEQIVGDFTSLILLDVDVKPEQTFFTRVKETQST 1162 Query: 137 ISNALEHQDYPFEDLVSQLQITRDFGR------NPLFDVMFXXXXXXXXXXXXXXXXXXE 190 + + LEH+ Y + RDF R + ++F + Sbjct: 1163 LLDGLEHRHY------DGVNFIRDFTRYHQMTPKAVMPIVFTSMLAGAGAFSWE-----Q 1211 Query: 191 LQMKPYPYTTTTSRFDLTLDGE--ERAGELVFTLEYATDLFTRETVMRLIRYFRTILLEV 248 L Y + T + LD E+ GEL+ + Y +LF + + + F +L ++ Sbjct: 1212 LGSLRYIHARTPQVY---LDNVVIEKNGELLISWNYVEELFDIDVIEAMFSQFVDLLEQL 1268 Query: 249 LKHPAQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVTFRN 308 +K ++ + L + L+ ++N+T + P T++QLF +VK P++ AV F Sbjct: 1269 VK----QSDITSLQMKESDQTLIEQYNETTEKIPS-TTLYQLFTDQVKRTPNEVAVVFEQ 1323 Query: 309 QSITYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPIDPG 368 + +TY EL+ GIG V L+ R VD PIDP Sbjct: 1324 KWLTYSELHKRSNQIAHFLKEQGIGLGDKVGLLAKRRVDTIVNMLGILKAGAAYVPIDPD 1383 Query: 369 LPANRIAYMLDDAGVQVILTNTSVENQGNRIVLDMRSLGLDHGAPLPVPPVHSSRNLAYC 428 P +R Y+L ++ + +L + E L +P + ++AY Sbjct: 1384 HPLDRQTYILKNSSCKFLLEPSLYEEND-----------LSFYTTEDMPAIAGPEDIAYI 1432 Query: 429 MYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESILPLLA 488 +YTSG+TG PKG+++ H+++ N I+ + + +S++++ FD+ + L Sbjct: 1433 IYTSGSTGKPKGVIITHQAVTNTIQDINQKYEVNEDDRIISISSMCFDLSVYDIFGALST 1492 Query: 489 GYQLVIADELQQKDVHALLALVKQAEISVMQTTPSRXXXXXXXXXXXXXXXXXRYLLIGG 548 G LV+ +L +D+ L+ V++ I++ T P+ R +L G Sbjct: 1493 GAMLVMIRDL--RDMQELIRTVERRGITIWNTVPAIMDLALDQVGSHFEHSSLRLVLHSG 1550 Query: 549 EPLPQALAEQARSILPGGRIFNLYGPTETTIWSTAQEVTA-----GPVNIGKPLKNTQVY 603 + +P +L E+ + P + +L G TE +IWS V + G PL N Y Sbjct: 1551 DWIPLSLPEKIKRHFPIAEVVSLGGATEASIWSIYYPVKQVESHWNSIPYGMPLANQTYY 1610 Query: 604 ILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGDIARWT 663 +LN E + P+GV G LYIGG G+ +GY N+ + T + F+ +P IY TGD + Sbjct: 1611 VLNYEKKMCPVGVIGDLYIGGVGLAKGYLNDEKKTNEAFVSHP--DFGLIYKTGDCGKMH 1668 Query: 664 EEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLVAYYTA 723 EG IE+LGR D+QVKI+GYR+EL EI L T+ +E +VV Q D+ LVAY Sbjct: 1669 SEGYIEFLGRQDYQVKIQGYRVELEEISHCLLTYKQVEHAVVIDQTDENGIKFLVAYVVT 1728 Query: 724 ARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPVTVTLVQPGETRK 783 + +S ELR+ L LP YMIP +F+ + ++PL +GKLD KALP P + + Sbjct: 1729 EQNISTTELRKHLRDHLPDYMIPSYFVYLDQLPLTPNGKLDRKALPT-------PEKQKN 1781 Query: 784 -----PQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINK-------- 830 P+ E+E+ L IW++VL+I GV D FF +GG+SI+ +Q+ + + Sbjct: 1782 EVFIAPKTEMEKILTSIWQEVLKIDQVGVNDHFFALGGDSIKAIQVSVRLYRQGFELEPK 1841 Query: 831 ---CFPVSFQFTHFIERQTIERIADFIKEAIQEERKEELPFIAADPANRH---------- 877 FP+ F+++ + I + K L + N+H Sbjct: 1842 NLFSFPILRDMVQFVKKLDQFSSSQTNDVNIMNDNKATLLNVKDKQLNQHTLTKIQEKMP 1901 Query: 878 -----EPFPLTNVQMAYYLGRSSHFELGGVSTHSYLEMATELDIRRLNQCLNTLIQRHPA 932 +PL Q Y ++ + + + ELDI+ QC L+ RH + Sbjct: 1902 DIKIERIYPLAPFQEVIYEHATNEPDTNAYFEQTIWALEGELDIKLFIQCFQQLVDRHDS 1961 Query: 933 LHTVYLPDATQQILPEVPEYTICEYDLSGYTEEAKNKRITK-ERDRMSHHIFNPNVWPLF 991 L T+ + D +Q P + YD+ +E +TK E+ N N+ F Sbjct: 1962 LRTIIVQD--EQAKP----WQAVLYDVQINSEIKNLIEMTKQEQQEFLDQWMNENLSQGF 2015 Query: 992 E-------IVAFRSSPEESLLCISFDLLIMDAYSLEILQEEIMALYADRSL-QLEELSI- 1042 + + F+ E + S L+ D +S+ IL +E+ LY + EL + Sbjct: 2016 KNGELMTRLCIFQLGNNEYKVIWSSHHLLCDGWSVSILIDELFQLYETTNAGTTAELPMV 2075 Query: 1043 ----TFRDYLVGYQQMKSGKWYLEDKEYWLQKVEDFPLAPGLPLLTQPQHVKNPYFKRKS 1098 TF D+ + K+ + +W + + +P P + F Sbjct: 2076 KPFETFIDWTLAQDHEKA-------RHFWRDYLSGYNQKISIPKKKVPSKSEGLNFTFMD 2128 Query: 1099 KHYSQQHWRQLKQISQNHNLTPSAVLCTVYAEVLANWSNQPQFGLNLTLFNRLPLHSDVD 1158 + QL+ +N+T + L V+ +L ++ + L + R P ++ Sbjct: 2129 LTLDKDLTNQLQTFVTKNNITMNTALLAVWGILLGKFNGTREVVLPNLVSVRPPEVEGIE 2188 Query: 1159 KLIGDFTSLLLLEVRMNPNDSFWEKAGNIQRVLMEALAHRHFDGIDVMRE 1208 + G FT++L + + SF + +Q ++ + ++ +D+ ++ Sbjct: 2189 NMFGLFTNVLPIRLAWTETQSFVDFLQKVQLETLKCNEYAYYSFVDIQKQ 2238 >C3DKL0.1 C3DKL0_BACTS AMP-binding enzyme Length = 2338 Score = 1264 bits (3270), Expect = 0.0, Method: Compositional matrix adjust. Identities = 721/1851 (38%), Positives = 1076/1851 (58%), Gaps = 96/1851 (5%) Query: 57 IKQLAAEQEATLYMVLFAVWNILLAKLSDQEEIIVGVPTSGRNHSDIEHVIGMFVNTLPI 116 I+++ Q+ L+ A + LA +DQE I +G+P +N E++ + +P+ Sbjct: 62 IQKINKSQDLLLFSWFQAALRVCLAHYTDQERITIGIPIIEKNLEQSENLNKL----IPL 117 Query: 117 KSRISAKLTFAEILHAMKANISNALEHQDYPFEDLVSQLQITRDFGRN----PLFDVMFX 172 S I H + F+ LV++++ T FG PL +++ Sbjct: 118 GSEI----------------------HPHHTFKQLVNEIEQTTLFGYENQEYPLSELLVK 155 Query: 173 XXXXXXXXXXXXXXXXXELQMKPYPYTTTTSRFDLTLDGEERAGELVFTLEYATDLFTRE 232 E ++ Y + +L L + E+ E+ +R Sbjct: 156 HNLTPFQIVIGMEGLHNENSLEEY------AENNLALWIRRKWNEIHNEFEFQISCKSRS 209 Query: 233 --TVMRLIRYFRTILLEVLKHP--AQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVH 288 ++ + + +L +V ++P A K I + +E LN F QT + + + Sbjct: 210 FSSLQQFANSYCYVLKQVSQNPNLALKDICIIAEEEKELLEGLNTF-QTGIDLFQ--SFQ 266 Query: 289 QLFAARVKEHPHQAAVTFRNQSITYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDM 348 LF A+V + P Q AV +QS+TY ELN G+ + I+ ++ RS++M Sbjct: 267 DLFEAQVLKTPDQIAVVCNDQSLTYRELNKKANQLASILQSKGVSKESIIGVMVDRSLEM 326 Query: 349 XXXXXXXXXXXXXXXPIDPGLPANRIAYMLDDAGVQVILTNTSVEN----QGNRIVLDMR 404 PIDP P RI YML D+ + +L+ + E G + LD Sbjct: 327 IIGMMGILKAGAAYLPIDPNYPTERIEYMLQDSQAKYLLSKRTEEVLPQFAGEVLYLDKE 386 Query: 405 SLGLDHGAPLPVPPVHSSRNLAYCMYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKG 464 L G + H+ +LAY +YTSG+TG PKG+++E +SL++F + + + + Sbjct: 387 YLF--QGEESNLVREHNPNDLAYVIYTSGSTGNPKGVMIEQKSLVHFLNVMREKVK--AN 442 Query: 465 ETFLSLTTVSFDIFWLESILPLLAGYQLVIADELQQKDVHALLALVKQAEISVMQTTPSR 524 ++FL L +VSFDI LE LPL G ++VIA E +Q L LVK+ ++ + ++TPSR Sbjct: 443 QSFLFLASVSFDISLLEICLPLTQGSKVVIATE-EQFATKELAHLVKKHKVDLWESTPSR 501 Query: 525 XXXXXXXXXXXXXXXXXRYLLIGGEPLPQALAEQARSILPGGRIFNLYGPTETTIWSTAQ 584 + +L+ GE L E+ R I I N+YGPTETTI +T + Sbjct: 502 MEVILSDPEGANFLKDLKSILLAGEAFSIDLVEKIRCI-SEATILNIYGPTETTICATVK 560 Query: 585 EV-TAGPVNIGKPLKNTQVYILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFI 643 ++ T+ V IGKP N YILN L+P G+PG L I G V RGY +LT ++F+ Sbjct: 561 DLSTSKEVTIGKPNPNYHSYILNKYGQLKPFGIPGELCIAGVAVARGYLGKSKLTDEKFV 620 Query: 644 DNPYRPGEQIYCTGDIARWTEEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKS 703 +P+ GE +Y TGD+ RW G +EYLGR D QVKIRGYRIEL EIE QL +P I ++ Sbjct: 621 QSPFAAGEMMYHTGDLVRWLPNGELEYLGRMDHQVKIRGYRIELREIETQLREYPEINQA 680 Query: 704 VVRAQRDDQDEPMLVAYYTAARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKL 763 +V Q + +L AYY + VS E+R++L LP +MIP+ +++ +IPL +GK+ Sbjct: 681 IVVDQVYG-NRKLLAAYYVSDNKVSFGEIRKYLSDKLPEFMIPEKMIQVEEIPLNPNGKV 739 Query: 764 DVKALPPVTVTLVQPGETRKPQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQ 823 D K L +T T P++E+E+KL+ W+KV+ I G+ D FF + G SI+ +Q Sbjct: 740 DRKRLLDITQTDYVSIPYVAPRNEIEQKLVRAWEKVMEIEGIGIHDNFFALKGESIKALQ 799 Query: 824 LVYEINK-CFPVSFQFTHFIERQTIERIADFIKEAIQEERKEELPFIAADPANRHEPFPL 882 ++ + K C +S T F + TI +++ +K +EE E P D +N PF L Sbjct: 800 VINLLRKDCLKIST--TDFFKHPTIAQLSSCVKLEHKEENFESKPTHVKDLSN---PFSL 854 Query: 883 TNVQMAYYLGRSSHFELGGVSTHSYLEMATELDIRRLNQCLNTLIQRHPALHTVYLPDAT 942 T VQ AY LGR+S FEL G+S +Y E T LDI RL++ +I RHP L V LP+ Sbjct: 855 TEVQTAYMLGRNSQFELSGISPQTYFEYETALDINRLSKSFQKVIHRHPMLRAVILPEGK 914 Query: 943 QQILPEVPEYTICEYDLSGYTEEAKNKRITKERDRMSHHIFNPNVWPLFEIVAFRSSPEE 1002 QQIL VP+Y I L + ++ R+ +ER RM++H+F WPLFE+ AF + Sbjct: 915 QQILQSVPDYEIEIESLIDLDDRNQHARLQEERSRMTNHVFPLGQWPLFELKAFLLKEDT 974 Query: 1003 SLLCISFDLLIMDAYSLEILQEEIMALYADRSLQLEELSITFRDYLVGYQQMKSGKWYLE 1062 LLC +D L+MD S+ I+ ++++ Y + +LE LS F+DY+ Y +M+ + Y Sbjct: 975 YLLCFRYDALLMDGASMNIVGQDLLHYYYKPNQKLESLSFDFQDYMFIYDEMEQSEEYKT 1034 Query: 1063 DKEYWLQKVEDFPLAPGLPLLTQPQHVKNPYFKRKSKHYSQQHWRQLKQISQNHNLTPSA 1122 K+YW K+ DFP AP L L P + P F+ +K + W +L++++Q +TPSA Sbjct: 1035 AKDYWTSKLPDFPFAPSLLLKKDPAEIATPKFQSLTKILDNKKWTKLRKLAQEKEVTPSA 1094 Query: 1123 VLCTVYAEVLANWSNQPQFGLNLTLFNRLPLHSDVDKLIGDFTSLLLLEVRMNPNDSFWE 1182 +LCT+Y +VLA WSNQ + +NLT+FNR P+H +V++++GDFTSL+LL+V + P +F+ Sbjct: 1095 LLCTIYGDVLAYWSNQRRLAINLTVFNRYPVHDEVEQIVGDFTSLILLDVDVKPEQTFFT 1154 Query: 1183 KAGNIQRVLMEALAHRHFDGIDVMREISKRRALGNKALLPIVFTSALFDNG----EDGGE 1238 + Q L++ L HRH+DG++ +R+ ++ + KA++PIVFTS L G E G Sbjct: 1155 RVKETQSTLLDGLEHRHYDGVNFIRDFTRYHQMTPKAVMPIVFTSMLAGAGAFSWEQLGS 1214 Query: 1239 AAENHGEASDGEQSTNGITQTSQVYLDNQVALIHGKMVINWDYISELFDPAVMDAMFAQY 1298 H +T QVYLDN V +G+++I+W+Y+ ELFD V++AMF+Q+ Sbjct: 1215 LRYIHA-------------RTPQVYLDNVVIEKNGELLISWNYVEELFDIDVIEAMFSQF 1261 Query: 1299 LSRIEAILYSREEMGFPALPASDYTSIQAYNHTEEPIPSKTLHGLFEEAVHQTPYAVAIE 1358 + +E L + ++ + SD T I+ YN T E IPS TL+ LF + V +TP VA+ Sbjct: 1262 VDLLEQ-LVKQSDITSLQMKESDQTLIEQYNETTEKIPSTTLYQLFTDQVKRTPNEVAVV 1320 Query: 1359 ADNLSITYKELDDRADKVAGSLRSLGVSAGDRVGVIARKEIATFINILGILKSGAAYVPI 1418 + +TY EL R++++A L+ G+ GD+VG++A++ + T +N+LGILK+GAAYVPI Sbjct: 1321 FEQKWLTYSELHKRSNQIAHFLKEQGIGLGDKVGLLAKRRVDTIVNMLGILKAGAAYVPI 1380 Query: 1419 DPEYPQERVDYIRNHSQCKLVLETDYYEKNCRGQHPAE-LQRHNLPESLAYVIYTSGSTG 1477 DP++P +R YI +S CKL+LE YE+N + E + PE +AY+IYTSGSTG Sbjct: 1381 DPDHPLDRQTYILKNSSCKLLLEPSLYEENDLSFYTTEDMPAIAGPEDIAYIIYTSGSTG 1440 Query: 1478 NPKGVMISHQAACNTVQDINQKFQVGAADRMLGISSLCFDLSVYDIFGAFAAGATLVLVK 1537 PKGV+I+HQA NT+QDINQK++V DR++ ISS+CFDLSVYDIFGA + GA LV+++ Sbjct: 1441 KPKGVIITHQAVTNTIQDINQKYEVNEDDRIISISSMCFDLSVYDIFGALSTGAMLVMIR 1500 Query: 1538 DQKDIRQLADTLSAQKITIWNSVPAIMDRVGSEIRAQGIYQENLDLRLVLLSGDWIPLHL 1597 D +D+++L T+ + ITIWN+VPAIMD ++ G + E+ LRLVL SGDWIPL L Sbjct: 1501 DPRDMQELIRTVERRGITIWNTVPAIMDLALDQV---GSHFEHSSLRLVLHSGDWIPLSL 1557 Query: 1598 PETVKQLFPAAKLISCGGATEASIWSIYYPIDEVMPQWTSIPYGMPLANQQFYVLNQQMD 1657 PE +K+ FP A+++S GGATEASIWSIYYP+ +V W SIPYGMPLANQ +YVLN + Sbjct: 1558 PEKIKRHFPIAEVVSLGGATEASIWSIYYPVKQVESHWNSIPYGMPLANQTYYVLNYEKK 1617 Query: 1658 YCPLEVSGELYIGGSGVANGYLNDPEKPSHSFIHHPELGYIYRTGDYGVLHRDGCIEFLG 1717 CP+ V G+LYIGG G+A GYLND +K + +F+ HP+ G IY+TGD G +H +G IEFLG Sbjct: 1618 MCPVGVIGDLYIGGVGLAKGYLNDEKKTNEAFVSHPDFGLIYKTGDCGKMHSEGYIEFLG 1677 Query: 1718 RKDQQVKVGGYRIELGEVEAQLLRCGGVRHAVVLAADGED--KRLGAYLIPDSQSADQAA 1775 R+D QVK+ GYR+EL E+ LL V HAVV+ E+ K L AY++ +Q Sbjct: 1678 RQDYQVKIQGYRVELEEIAHCLLTYKQVEHAVVIDQTDENGIKFLVAYVV-----TEQNI 1732 Query: 1776 FINEVRARIAKVLPDYMIPHYFVVLEQFPLTANGKMDVQALLKLQPAGNKQTS-AYTAPR 1834 E+R + LPDYMIP YFV L+Q PLT NGK+D +AL P KQT+ + AP+ Sbjct: 1733 STTELRKHLRDHLPDYMIPSYFVYLDQLPLTPNGKLDRKAL----PTPEKQTNEVFIAPK 1788 Query: 1835 NDVEERIVNIFKELLEADQVGTLDNFFEMGINSVQIAMINNKL-KQEFQKE 1884 ++E+ + +I++E+L+ DQVG D+FF +G +S++ ++ +L +Q F+ E Sbjct: 1789 TEMEKILTSIWQEVLKIDQVGVNDHFFALGGDSIKAIQVSVRLYRQGFELE 1839 Score = 346 bits (888), Expect = 1e-92, Method: Compositional matrix adjust. Identities = 305/1251 (24%), Positives = 548/1251 (43%), Gaps = 121/1251 (9%) Query: 19 FSGEIPLLHLPADHSRPAFKTYRGSAEMFSIPKEQVLEIKQLAAEQEATLYMVLFAVWNI 78 F+ + L PA+ + P F++ + ++ ++++LA E+E T +L ++ Sbjct: 1048 FAPSLLLKKDPAEIATPKFQSLTKI-----LDNKKWTKLRKLAQEKEVTPSALLCTIYGD 1102 Query: 79 LLAKLSDQEEIIVGVPTSGRN--HSDIEHVIGMFVNTLPIKSRISAKLTFAEILHAMKAN 136 +LA S+Q + + + R H ++E ++G F + + + + + TF + ++ Sbjct: 1103 VLAYWSNQRRLAINLTVFNRYPVHDEVEQIVGDFTSLILLDVDVKPEQTFFTRVKETQST 1162 Query: 137 ISNALEHQDYPFEDLVSQLQITRDFGR------NPLFDVMFXXXXXXXXXXXXXXXXXXE 190 + + LEH+ Y + RDF R + ++F + Sbjct: 1163 LLDGLEHRHY------DGVNFIRDFTRYHQMTPKAVMPIVFTSMLAGAGAFSWE-----Q 1211 Query: 191 LQMKPYPYTTTTSRFDLTLDGE--ERAGELVFTLEYATDLFTRETVMRLIRYFRTILLEV 248 L Y + T + LD E+ GEL+ + Y +LF + + + F +L ++ Sbjct: 1212 LGSLRYIHARTPQVY---LDNVVIEKNGELLISWNYVEELFDIDVIEAMFSQFVDLLEQL 1268 Query: 249 LKHPAQKTGLIHLPDNQETDRLLNRFNQTAGEYPEHLTVHQLFAARVKEHPHQAAVTFRN 308 +K ++ + L + L+ ++N+T + P T++QLF +VK P++ AV F Sbjct: 1269 VK----QSDITSLQMKESDQTLIEQYNETTEKIPS-TTLYQLFTDQVKRTPNEVAVVFEQ 1323 Query: 309 QSITYDELNXXXXXXXXXXXXXGIGPDQIVALITTRSVDMXXXXXXXXXXXXXXXPIDPG 368 + +TY EL+ GIG V L+ R VD PIDP Sbjct: 1324 KWLTYSELHKRSNQIAHFLKEQGIGLGDKVGLLAKRRVDTIVNMLGILKAGAAYVPIDPD 1383 Query: 369 LPANRIAYMLDDAGVQVILTNTSVENQGNRIVLDMRSLGLDHGAPLPVPPVHSSRNLAYC 428 P +R Y+L ++ +++L + E L +P + ++AY Sbjct: 1384 HPLDRQTYILKNSSCKLLLEPSLYEEND-----------LSFYTTEDMPAIAGPEDIAYI 1432 Query: 429 MYTSGTTGLPKGILVEHRSLLNFFSAISDVLSFGKGETFLSLTTVSFDIFWLESILPLLA 488 +YTSG+TG PKG+++ H+++ N I+ + + +S++++ FD+ + L Sbjct: 1433 IYTSGSTGKPKGVIITHQAVTNTIQDINQKYEVNEDDRIISISSMCFDLSVYDIFGALST 1492 Query: 489 GYQLVIADELQQKDVHALLALVKQAEISVMQTTPSRXXXXXXXXXXXXXXXXXRYLLIGG 548 G LV+ + +D+ L+ V++ I++ T P+ R +L G Sbjct: 1493 GAMLVMIRD--PRDMQELIRTVERRGITIWNTVPAIMDLALDQVGSHFEHSSLRLVLHSG 1550 Query: 549 EPLPQALAEQARSILPGGRIFNLYGPTETTIWSTAQEVTA-----GPVNIGKPLKNTQVY 603 + +P +L E+ + P + +L G TE +IWS V + G PL N Y Sbjct: 1551 DWIPLSLPEKIKRHFPIAEVVSLGGATEASIWSIYYPVKQVESHWNSIPYGMPLANQTYY 1610 Query: 604 ILNDELLLQPIGVPGILYIGGHGVVRGYQNNPELTAQRFIDNPYRPGEQIYCTGDIARWT 663 +LN E + P+GV G LYIGG G+ +GY N+ + T + F+ +P IY TGD + Sbjct: 1611 VLNYEKKMCPVGVIGDLYIGGVGLAKGYLNDEKKTNEAFVSHP--DFGLIYKTGDCGKMH 1668 Query: 664 EEGTIEYLGRADFQVKIRGYRIELAEIEQQLDTHPAIEKSVVRAQRDDQDEPMLVAYYTA 723 EG IE+LGR D+QVKI+GYR+EL EI L T+ +E +VV Q D+ LVAY Sbjct: 1669 SEGYIEFLGRQDYQVKIQGYRVELEEIAHCLLTYKQVEHAVVIDQTDENGIKFLVAYVVT 1728 Query: 724 ARTVSGAELREFLLKFLPAYMIPQHFMEIGKIPLMISGKLDVKALPPVTVTLVQPGETR- 782 + +S ELR+ L LP YMIP +F+ + ++PL +GKLD KALP Q E Sbjct: 1729 EQNISTTELRKHLRDHLPDYMIPSYFVYLDQLPLTPNGKLDRKALP---TPEKQTNEVFI 1785 Query: 783 KPQDEVEEKLLEIWKKVLRIGDTGVQDGFFEMGGNSIQIMQLVYEINK-----------C 831 P+ E+E+ L IW++VL+I GV D FF +GG+SI+ +Q+ + + Sbjct: 1786 APKTEMEKILTSIWQEVLKIDQVGVNDHFFALGGDSIKAIQVSVRLYRQGFELEPKNLFS 1845 Query: 832 FPVSFQFTHFIER-------------------QTIERIADF-IKEAIQEERKEELPFIAA 871 FP+ F+++ T+ I D + + + +E++P I Sbjct: 1846 FPILRDMVQFVKKLDHFSSSQTNNVNIMNDNKATLLNIKDKQLNQQTLTKIQEKMPDIKI 1905 Query: 872 DPANRHEPFPLTNVQMAYYLGRSSHFELGGVSTHSYLEMATELDIRRLNQCLNTLIQRHP 931 + +PL Q Y ++ + + + ELDI+ QC L+ RH Sbjct: 1906 ERI-----YPLAPFQEVIYEHATNEPDTNAYFEQTIWALEGELDIKLFIQCFQQLVDRHD 1960 Query: 932 ALHTVYLPDATQQILPEVPEYTICEYDLSGYTEEAKNKRITK-ERDRMSHHIFNPNVWPL 990 +L T+ + D +Q P + YD+ +E +TK E+ N N+ Sbjct: 1961 SLRTIIVQD--EQAKP----WQAVLYDVQINSEIKNLIEMTKQEQQEFLDQWMNENLSQG 2014 Query: 991 FE-------IVAFRSSPEESLLCISFDLLIMDAYSLEILQEEIMALY-ADRSLQLEELSI 1042 F+ + F+ E + S L+ D +S+ IL +E+ LY + EL + Sbjct: 2015 FKNGELMTRLCIFQLGNNEYKVIWSSHHLLCDGWSVSILIDELFQLYETTNAGTTAELPM 2074 Query: 1043 -----TFRDYLVGYQQMKSGKWYLEDKEYWLQKVEDFPLAPGLPLLTQPQHVKNPYFKRK 1097 TF D+ + K+ + +W + + +P P + F Sbjct: 2075 VKPFETFIDWTLAQDHEKA-------RHFWRDYLSGYNQKISIPKKKVPSKSEGLNFTFM 2127 Query: 1098 SKHYSQQHWRQLKQISQNHNLTPSAVLCTVYAEVLANWSNQPQFGLNLTLFNRLPLHSDV 1157 + QL+ +N+T + L V+ +L ++ + L + R P + Sbjct: 2128 DLTLDKDLTDQLQTFVTKNNITMNTALLAVWGILLGKFNGTREVVLPNLVSVRPPEVEGI 2187 Query: 1158 DKLIGDFTSLLLLEVRMNPNDSFWEKAGNIQRVLMEALAHRHFDGIDVMRE 1208 + + G FT++L + + SF + +Q ++ + ++ +D+ ++ Sbjct: 2188 ENMFGLFTNVLPIRLAWTETQSFVDFLQKVQLETLKCNEYAYYSFVDIQKQ 2238 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.319 0.137 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 11,221,826,292 Number of extensions: 476646828 Number of successful extensions: 1353418 Number of sequences better than 1.0e-05: 13334 Number of HSP's gapped: 1249045 Number of HSP's successfully gapped: 30561 Length of query: 1943 Length of database: 3,060,696,203 Length adjustment: 151 Effective length of query: 1792 Effective length of database: 1,638,122,938 Effective search space: 2935516304896 Effective search space used: 2935516304896 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 139 (58.2 bits)