BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0489.0022.p (2331 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B8I5H5.1 B8I5H5_CLOCE Amino acid adenylation domain protein 944 0.0 C0ZEG3.1 C0ZEG3_BREBN Putative mixed polyketide synthase/non-rib... 704 0.0 C2XEJ7.1 C2XEJ7_BACCE Putative uncharacterized protein 652 0.0 O30409.1 TYCC_BREPA Tyrocidine synthetase 3 ATP-dependent aspara... 639 e-180 B2IXJ9.1 B2IXJ9_NOSP7 Amino acid adenylation domain protein EC=5... 638 e-180 >B8I5H5.1 B8I5H5_CLOCE Amino acid adenylation domain protein Length = 3695 Score = 944 bits (2439), Expect = 0.0, Method: Compositional matrix adjust. Identities = 562/1651 (34%), Positives = 893/1651 (54%), Gaps = 68/1651 (4%) Query: 679 VVLVLTDSTDWGQALAGEISRHTPHVIHARLAAAYQRESPALYSLAGTEADFCQLLKDTG 738 V ++ D G+ LA ++ + +++ + + Y E DF +L + Sbjct: 966 VTIIFNDEYGMGEELAQKLRAAGTETVEVEFGIDFRQINHSKYMTGTDEGDFRKLFSELN 1025 Query: 739 AMKISKILFAAGMD-DCDTGSISEEERXXXXXXXXXXXXKAWVKQEMNRTELILAGKNGQ 797 +++I++ + ++ D D +E KA + N +L++ N Sbjct: 1026 GRAVNRIIYLSALNFDTDMDIDGLDEAMERGVYNLHRLTKAISESMQNDLDLVIIADNAS 1085 Query: 798 RVLPSDQKIYPYFASLYGMGKVIREEYSGLHCRCIDCDESAPVRELADEVFRPSDHYQIA 857 V+ +KI SLY MG+VI +EY + CRCID D++ + E+ + + ++ Sbjct: 1086 EVVEYQEKINALSGSLYAMGRVIGQEYDNIRCRCIDIDKAVDTDLIISELAQKKFLFNVS 1145 Query: 858 IREGKKYYPQLTPVDLDAFDNSMTGFKEXXXXXXXXXXXXXXXXXAQHIALKHKVKLVLI 917 R G++Y L + +E +++A + +V LV+I Sbjct: 1146 YRNGQRYIQNLQRQSPYSNGGDKIQIREEGVYIVAGGLGGIGLEICRYLAAEKRVNLVMI 1205 Query: 918 SRSRLPARESWEELIQSAQEPDERAAL-----IHSLKHLESNGSQLFTYSADVAELDELS 972 +RS LP R W++L+++ E I S+K L+ GS++ +SAD+A++ + Sbjct: 1206 NRSPLPERSLWDDLLKNTYEGINDTDYNIIDRIQSIKELKDMGSKVLCFSADLADMASVR 1265 Query: 973 PVISRITSQLGKIDGIIHAAGLPGSGLLIEKDGQSFAASVAAKIKGTRHLHLLTRDNPPD 1032 V+ + I+G+I+ AG+ G+LI+KD ++ +A K+ GT L LT ++ D Sbjct: 1266 LVLDEVRKHHANINGVINLAGVFEEGILIKKDTEALKRVIAPKVNGTLILDRLTENDNLD 1325 Query: 1033 FLLLFSSIASVVGGIYLGDYVAGNSYLDAFSGLLAGHTR-LISINWTTWMNTGMAKNTGG 1091 F ++FSSIAS +GG G+Y A N+++D+F+ R +ISINWT W GMA Sbjct: 1326 FFVMFSSIASFIGGHGQGEYSAANAFMDSFAEYKNRTGRKVISINWTGWNQVGMASQYNL 1385 Query: 1092 SLDV-AFRSILPRHALHAFDQILGKKINNIVVGSIQF---------NNDLFWNRPLPVSL 1141 S F+ I A+ AFD+ L + +V+G + + N + ++ + SL Sbjct: 1386 SDGRRIFKLISKEKAIKAFDRALTASLPRVVIGELDYEFMAEYAMDNAYIQLSQEIKNSL 1445 Query: 1142 APAIR--EQIKHPEAEIDVRLTGRADQSYTEIEQQIARIWGNLFQMPNIDIQDNFYELGG 1199 P I+ +Q+K P V GR +Q YT +E+ +A +WG + + IDI +N Y LGG Sbjct: 1446 KPYIKMPQQVKQPGKRKIVLPKGRQNQEYTPMEKGVAAVWGEVLGLEEIDIYENLYNLGG 1505 Query: 1200 TSIMGIKIANRINEQYRVTMTIQDVFTHLTVASLGKLVEQKLGTKTEAGAVNKQEVEYAK 1259 SI+ ++IAN IN++ ++ I D+F +LTV L +E K K E + +E E Sbjct: 1506 DSIIALRIANEINKKLNASIRISDLFEYLTVQRLAAFLEDKTPEK-EVSVKDLRESEKEH 1564 Query: 1260 TSMPLSHAQRRIWFLQKMNPDLVAYNLPFIRYFDMAIDLELLQQAASFLAGRHLLMRTKY 1319 T LS+ Q+RIWFLQ +P + YNLP + + +++++L++A + L RH ++RT + Sbjct: 1565 TYYELSNIQKRIWFLQNYDPQMTVYNLPLVSSINAELNVQVLKEAVNLLIQRHEVLRTVF 1624 Query: 1320 VLKDGNPVQEVLPAYVPAVQSIDAAGQSDPELFVKMNIHQQKMKPFNLEMPPYRIYLYTI 1379 ++G P Q++L Y + +D G+ E + I Q+ KPFNL PP R+ +Y + Sbjct: 1625 GEENGEPYQKILTVYEYEPEVVDLTGEPHKESVLNELIAQENKKPFNLSNPPMRVVVYKL 1684 Query: 1380 SDERACLYINFHHILTDGWSIDIYYRELFSLYQAFLHQQPPRLPEVKEDYFDWILEQKAW 1439 S CLY+N HHI+TDGWS+ I+ EL LY+ + ++ L + Y DW+ +Q W Sbjct: 1685 SSSSYCLYLNIHHIVTDGWSMGIFSYELMKLYEGIVLEKVVELEPLNFRYTDWVKQQLEW 1744 Query: 1440 EESEAFVEHEQFWLKELAKPLPVLSLPSDHKAPAVQTYRGSFHKFTISGELYRKLKAHLE 1499 ++S FVE E +WL+EL KPLPVL+LP D+K P +QTY GSF KF+I G KLK Sbjct: 1745 QDSSEFVEMENYWLQELYKPLPVLNLPVDYKRPQMQTYNGSFIKFSIDGNTTAKLKEFAR 1804 Query: 1500 TQQITANNFLLSAYFLLLHNLSQEQDIIIGVPASGRNEQKWESVAGIFINTLCIRIHFQG 1559 IT N LLSAYF+LL ++ ++DI++G+P +GR ++ E++ G+FINTL IRI+F+ Sbjct: 1805 QHNITLNMALLSAYFVLLKKITADKDIVVGLPVTGRENKELENIMGVFINTLSIRINFEN 1864 Query: 1560 ITTFMELQDAVKHKVWSAMDKAQYPFDLLVEKVNPDRDLSRNPIYNVLFQFYDKLYLENE 1619 I++ +L V+ K A +YPFDL++ K+NP+RDLSR+PI++ +FQ YDK+ E E Sbjct: 1865 ISSLNDLITCVREKCLKAYRNIKYPFDLIISKLNPERDLSRSPIFSTVFQLYDKIPPETE 1924 Query: 1620 GISPFELSCLAQETNQQIEISFEYNSDMYTDSTISRFAGYFLNIIGQVVDKPXXXXXXXX 1679 G S FELS L +E + +IEI EYN+D++ TI RFA Y+ NII + + Sbjct: 1925 GSSMFELSMLCREEDNRIEIRAEYNTDLFEKQTIERFAVYYTNIINAFLIESDMSIDGIE 1984 Query: 1680 XXXXXXXXXXXSRFQGEQADLEDGQTIHGRFEAQVQKNPHAIALVYEEQQMTFQEVNGKA 1739 + F + + + +I FE Q + PH+ ++ T+ ++N A Sbjct: 1985 ILSLEETNRIITLFNATEREYDRTASIDTLFELQAKALPHSQCIIQGNTIYTYAQINSLA 2044 Query: 1740 NQLAWMLTGSGVQRNTPVGIFVDRSFSSVIGILAILKAGGAYVPLDPGYPEDRIAYILAH 1799 N +A L GV + VGI V+RS + ++GIL ILKAG AY+P+DP YP +RI Y+L Sbjct: 2045 NCIARTLLEKGVMKGDIVGIMVERSCNMLVGILGILKAGAAYLPIDPEYPGERINYMLND 2104 Query: 1800 SGAKWLLTENRYLQSVAAFAHEEGIQIINLSPVKEQSAVSQMYLADYEDELSRENPRTGG 1859 S K LLT + +VA + GI + +Y + E+ LS N Sbjct: 2105 SSVKVLLTSGKLKGTVAFY----GISV--------DMDDDGLYTGNCEN-LSINNR---- 2147 Query: 1860 HGPDRM-YIMYTSGSTGKPKGVLVTHSNVLNFVTWSIGELQLQPKDALLLVTSISFDISV 1918 PD + Y++YTSGSTGKPKGV++ H V NF+ + +++ ++L +TS+SFDI + Sbjct: 2148 --PDSLAYVIYTSGSTGKPKGVMIEHQAVCNFIEGMVEKIEFGSGKSILALTSMSFDIFI 2205 Query: 1919 FEIFAALLSGSRLCIASMEHLKDTECLLAYMEAQHITIWHSVPSLMVQLMTLLRHHPGRY 1978 E L G ++ IAS E KD + L ++ I + PS + L++ R Sbjct: 2206 LETILPLCIGMKVVIASEEQQKDPKLLSEIIKQNSIEMLQMTPSRLQLLLS-----DSRG 2260 Query: 1979 RHSPVLQQLRHLMLGGEAWSTSLAASLRETFPQAEIRNMYGPTEATIW--VSSYKPGPEI 2036 R S + Q+ LM+GGEA+ +L ++ A I NMYGPTE TIW + I Sbjct: 2261 RSSLSVPQV--LMVGGEAFPQALLDEVKRC-TNARIYNMYGPTETTIWSTIRELTDRSTI 2317 Query: 2037 DESHPVMLIGRPIANNRLIILDQYGNVCPPGVAGEIYIAGNNVTQGYYNDEEKTRMAFI- 2095 D IG+PIAN ++ I+ + GN+ P G+ GE+ I+G+ +++GY N E T F+ Sbjct: 2318 D-------IGKPIANTQVYIVSESGNLQPIGIPGELCISGDGLSRGYINRPELTLEKFLE 2370 Query: 2096 -PQSNGQIFYKTGDSGRYLPEGNVEFTGRRDQLVKVRGYRIELGEIEQALKELTSLQQIA 2154 P G+ Y+TGD ++LP+GN+E+ R D VK+RGYRIELGEIE+ L + + +++ A Sbjct: 2371 NPYMPGKKMYRTGDFVKWLPDGNIEYIRRIDHQVKLRGYRIELGEIEELLLKYSGVRE-A 2429 Query: 2155 VTAVK--DGETSKIVCLYTGDQPVPQNQLKDAVRKRLPEYMIPAQFFHVERFLLTPNGKM 2212 V VK D E+ K+ T D+ + + +LK + LP+YMIP +E LTPNGK Sbjct: 2430 VVDVKGEDSESRKLGAYVTADRDLTEVELKKYLENELPQYMIPTYIMVLEELPLTPNGKT 2489 Query: 2213 DWRSMEKFV---RETPGSIEAAGIRNEVDKKLSEIWKKLLGIPAVGIQENFFDIGGNSLL 2269 D +++ V T G ++A NE +K L I++ +L I G+ +NFF +GG+SL Sbjct: 2490 DRKALPCPVLTGLNTNGFVDAV---NETEKALQRIYQDVLNIQRAGVNDNFFALGGHSLK 2546 Query: 2270 VVQMQGMIQQEFFQDIPMMDLFKYTSIEKIS 2300 + I +E +IP+ +FK +I++++ Sbjct: 2547 ATILVSRIYKELGTEIPLSAVFKTPTIKELA 2577 Score = 782 bits (2020), Expect = 0.0, Method: Compositional matrix adjust. Identities = 436/1170 (37%), Positives = 670/1170 (57%), Gaps = 66/1170 (5%) Query: 1169 TEIEQQIARIWGNLFQMPNIDIQDNFYELGGTSIMGIKIANRINEQYRVTMTIQDVFTHL 1228 E E+ + RI+ ++ + + DNF+ LGG S+ + +RI ++ + + VF Sbjct: 2512 NETEKALQRIYQDVLNIQRAGVNDNFFALGGHSLKATILVSRIYKELGTEIPLSAVFKTP 2571 Query: 1229 TVASLGKLVEQKLGTKTEAGAVNKQEV-EY-------AKTSMPLSHAQRRIWFLQKMNPD 1280 T+ L A ++N ++ EY +S LS AQRRI+ ++ + + Sbjct: 2572 TIKEL-------------ACSINGTDISEYQPIIPVEKSSSYSLSPAQRRIYLMEAVTGE 2618 Query: 1281 LVAYNLPFIRYFDMAIDLELLQQAASFLAGRHLLMRTKYVLKDGNPVQEVLPAYVPAVQS 1340 AYN+P + + D E +QA L RH ++RT + DG PVQ V P + Sbjct: 2619 STAYNIPVLMDLEGEFDRERFEQAIKNLVARHEILRTYFDAVDGVPVQIVQECMEPEIAY 2678 Query: 1341 ID-AAGQSDPELFVKMNIHQQKMKPFNLEMPP-YRIYLYTISDERACLYINFHHILTDGW 1398 I+ SD + Q +KPFNL+ P +R+ + + R + + HHI+ DG Sbjct: 2679 IEIKEDDSDGNI-------QNLIKPFNLKSGPLFRVKVLLTDNGRKTIMFDIHHIICDGI 2731 Query: 1399 SIDIYYRELFSLYQAFLHQQPPRLPEVKEDYFDWILEQKAWEESEAFVEHEQFWLKELAK 1458 S+ I RE LY+ L E+ Y D++ + + SE + + E +W+ + Sbjct: 2732 SLGILTREFIELYRG------KELKELTVQYRDYVSWKSSLYGSERYKQQENYWMGMFSG 2785 Query: 1459 PLPVLSLPSDHKAPAVQTYRGSFHKFTISGELYRKLKAHLETQQITANNFLLSAYFLLLH 1518 +PVL++P+D+ P VQ+Y G F ++ E+ +KL +++ TA+ LL+ + +LL+ Sbjct: 2786 DIPVLNMPADYTRPTVQSYEGDTVYFELNKEMSKKLHEVETSEKTTASMTLLAVFNVLLY 2845 Query: 1519 NLSQEQDIIIGVPASGRNEQKWESVAGIFINTLCIRIHFQGITTFMELQDAVKHKVWSAM 1578 + ++DII+G+P +GR E++ G+FINTL +R +G TF V+H +A Sbjct: 2846 KYTGQEDIIVGMPVAGRGNADLENMLGVFINTLAMRNRPEGTKTFHNFLQEVRHNALNAY 2905 Query: 1579 DKAQYPFDLLVEKVNPDRDLSRNPIYNVLFQFYDKLY--LENEGI-----------SPFE 1625 + Y F+ LV+K+N RDLSR+P+++V+F + + +E EG+ S F+ Sbjct: 2906 ENQDYQFEELVDKLNVPRDLSRSPLFDVMFIMQNTSFPEIEEEGLRFKSREFDSKSSKFD 2965 Query: 1626 LSCLAQETNQQIEISFEYNSDMYTDSTISRFAGYFLNIIGQVVDKPXXXXXXXXXXXXXX 1685 L+ + E + EY + ++ T+ R + +FLNI+ QV++ P Sbjct: 2966 LTLESVEKENTLHFRLEYCTKIFMRETVERMSLHFLNILEQVLNNPDITLSDIDIITKEE 3025 Query: 1686 XXXXXSRFQGEQADLED-GQ-TIHGRFEAQVQKNPHAIALVYEEQQMTFQEVNGKANQLA 1743 F D D G+ T+H FE Q + P +IA++ E +T+ E+N KAN+LA Sbjct: 3026 KEKIEGVFNATDVDFGDRGKLTVHELFERQAEFRPDSIAVMCEGTGITYNELNEKANKLA 3085 Query: 1744 WMLTGSGVQRNTPVGIFVDRSFSSVIGILAILKAGGAYVPLDPGYPEDRIAYILAHSGAK 1803 +L G++R VGI V +S +IG+L ILKAGGAYVP+DP YP DRI Y+L HS + Sbjct: 3086 RLLQNEGIKREESVGIMVHKSIEMIIGMLGILKAGGAYVPVDPDYPADRIHYMLKHSQTR 3145 Query: 1804 WLLTENRYLQSVAAFAHEEGI--QIINLSPVKEQSAVSQMYLADYEDELSRENPRTGGHG 1861 +L+ + + EE +INLS ++A Y A+ LS N + + Sbjct: 3146 FLIIDQSSFEKTEMINTEENSLEVVINLSEGAGKTAGLIKYTAEDIKNLSPYNLKNKANP 3205 Query: 1862 PDRMYIMYTSGSTGKPKGVLVTHSNVLNFVTWSIGELQLQPKDALLLVTSISFDISVFEI 1921 + MYI+YTSGSTG PKGV V+H+N +N++ WSI + L KD + LVTS+SFDISVFEI Sbjct: 3206 KNLMYIIYTSGSTGLPKGVGVSHANAVNYLNWSIENMSLSHKDVMALVTSMSFDISVFEI 3265 Query: 1922 FAALLSGSRLCIASMEHLKDTECLLAYMEAQHITIWHSVPSLMVQLMTLLRHHPGRYRHS 1981 F +LLSG+ LCI +KD + Y++A +TIWHSVP+LM+QL+T ++ + Sbjct: 3266 FGSLLSGTCLCIVPDSRMKDGSLFMEYIDAGKVTIWHSVPALMIQLLTAVKSRK-TLGNQ 3324 Query: 1982 PVLQQLRHLMLGGEAWSTSLAASLRETFPQAEIRNMYGPTEATIWVSSY----KPGPEID 2037 + ++R +M+GGEAW+ LA +RE F A I NMYGPTEATIWV+S+ PG Sbjct: 3325 ELFSRIRCIMIGGEAWTYELAKDIREYFHHARIVNMYGPTEATIWVTSHDVRDNPG---- 3380 Query: 2038 ESHPVMLIGRPIANNRLIILDQYGNVCPPGVAGEIYIAGNNVTQGYYNDEEKTRMAF-IP 2096 S V+ IG+PI+NN+++ILD +CP G+ G+IYI+G NVT+GYY DEEKTR F + Sbjct: 3381 -SSTVIPIGKPISNNKVLILDSCKKMCPIGIPGDIYISGLNVTRGYYKDEEKTREVFTLY 3439 Query: 2097 QSNGQIFYKTGDSGRYLPEGNVEFTGRRDQLVKVRGYRIELGEIEQALKELTSLQQIAVT 2156 G I Y+TGD GRYL +G +E+ GR+D ++KVRGYRIE+GEIE L + + Q AV Sbjct: 3440 GEKGSIIYRTGDVGRYLSDGTIEYLGRKDGMIKVRGYRIEIGEIENVLLQNEEIIQAAVV 3499 Query: 2157 AVKDGETSKIVCLYTGDQPVPQNQLKDAVRKRLPEYMIPAQFFHVERFLLTPNGKMDWRS 2216 A K GETSK++C YT + +L+ + K+LP+YMIPAQF +E+ +LTPNGK+D +S Sbjct: 3500 AKKSGETSKLICYYTAPREHTYEELRGCLEKKLPDYMIPAQFIWLEKMILTPNGKIDRKS 3559 Query: 2217 MEKF-VRETPGSIEAAGI-RNEVDKKLSEIWKKLLGIPAVGIQENFFDIGGNSLLVVQMQ 2274 + + E S E + +EV++ L+ IW +LL + VG ++NFF +GGNSLLV QM Sbjct: 3560 LAALDIGEPFQSNENYAVPESEVERFLAGIWSQLLDMKKVGTKDNFFSLGGNSLLVNQMH 3619 Query: 2275 GMIQQEFFQDIPMMDLFKYTSIEKISDYLQ 2304 MI +++ I ++D+FKY +I K++D+++ Sbjct: 3620 SMIDEKYPGKIKVIDIFKYPTISKLADFME 3649 Score = 473 bits (1216), Expect = e-130, Method: Compositional matrix adjust. Identities = 250/625 (40%), Positives = 367/625 (58%), Gaps = 43/625 (6%) Query: 37 DVKRQDIAVIGIACRVPGADTPRRFWGNLLGRVNSIGAFPEERLQDLSPF-----IPELE 91 +V QD+A+IGI+ + F+ +L N +G FP+ R QD+ I E E Sbjct: 26 EVSTQDVAIIGISGKFASCGNMDEFYVSLRNGDNLVGKFPQRRKQDIDTILRYMGISEKE 85 Query: 92 ELLAHANHQAGYLEQIAHFDHPFFRIGGKEAMAMEPYQRLFLETAYHAIEDAGYGGDALK 151 + ++ +L +I FD F I KEA M+P QRLFL+TA++AIED+GYGGD L+ Sbjct: 86 TVY----YEGAFLNEIDKFDCSLFNISPKEAGLMDPNQRLFLQTAWNAIEDSGYGGDRLR 141 Query: 152 HSNTGVFVGLETAYQSHYRALLEHEDIS----SLTGSLVGLLANRISYFLDLRGPALVVN 207 S TGV+VG + YR ++ D S S+TG++ ++A+RISY LDL+GP+++V+ Sbjct: 142 SSRTGVYVGYCGDFNEDYRKYVQLMDPSMAALSVTGNIKSIVASRISYLLDLKGPSMLVD 201 Query: 208 TACSSGLVALHQACLALMNKECETALVGGVNLMVIPQATGKLNDL--ETSLGQVKAFDKD 265 TACSS LVA+H AC AL ECETA+ GGV L+++P N + E+S G ++FD+ Sbjct: 202 TACSSTLVAIHLACQALRKGECETAIAGGVKLILLPVDNNPQNGIGIESSSGVTRSFDEY 261 Query: 266 ADGTIWSEGITALLVKPLEKALKDRDPVYAVIKASGVNADGASNGLTAPNPEAETGLFIR 325 +DGT + EG+ A+++KPL+KA++DRD +Y++IK S VN DG S G+T PN +A++ + IR Sbjct: 262 SDGTGFGEGVAAIVLKPLKKAIEDRDNIYSIIKGSAVNQDGTSMGITVPNAQAQSDVIIR 321 Query: 326 TWEKAKIDPLSISYVEAHGTGTLLGDSIELQAINDAFKKYTNTPHICGIGSVKTNIGHTV 385 W+ AKIDP +ISY+EAHGTGT LGD +E+ I AF +YTN C + SVKTNIGH Sbjct: 322 AWKDAKIDPETISYIEAHGTGTNLGDPVEIDGIEMAFAQYTNKKQFCAVSSVKTNIGHLD 381 Query: 386 AASGLASLLKVILSLKHKKIPPSLNYQSPNPFIDADHSAIYVNTEVKDWERRDTARRAGV 445 +A+G+A LLK +LSLKHK++ PSL++ PN I+ +S +Y+N ++ WE RR G+ Sbjct: 382 SAAGIAGLLKAVLSLKHKELFPSLHFDRPNQKINFQNSPVYINDSLEQWENHGGPRRCGI 441 Query: 446 NSFGFSGTNCHVVVEEAPEMNHQAGEG-SSPFHFLTLSAGSTHGLARLIQAYYAFLQDND 504 +SFG SGTNCH+V+EE P++ E +H TLS+ + +GL ++ Y +L Sbjct: 442 SSFGLSGTNCHLVLEEPPQIKSIPEESPGCNYHIFTLSSQNINGLMEQLKNYEKYLNRER 501 Query: 505 QIDLEDLCYTANTGRGHSDSRAAFVFATRDELMKQLANADX------------------- 545 ++ L LC T NTGRGH + R AFV +++EL +++ Sbjct: 502 EVSLGSLCSTTNTGRGHYNFRLAFVITSKNELKEKIQKLSTGGLENFEKYGVYFGKHKIV 561 Query: 546 -----XXXXXXXXXXXXXXXXVQREDLLTAAEELEPDRQNLQLTYEKLAERYVGGFSVDW 600 +Q E L A + + Q +++ E + YV G +V W Sbjct: 562 DKEKESRGNNEYSQEEIADLSLQTETYLNEA--INNESQQKKVSLENICALYVNGANVQW 619 Query: 601 AALYPQ-KRQKLNLPGYPFEKIKLW 624 LY K++LPGY F K + W Sbjct: 620 NRLYKSGSYAKVSLPGYSFMKKRCW 644 >C0ZEG3.1 C0ZEG3_BREBN Putative mixed polyketide synthase/non-ribosomal peptide synthetase Length = 2885 Score = 704 bits (1816), Expect = 0.0, Method: Compositional matrix adjust. Identities = 472/1555 (30%), Positives = 788/1555 (50%), Gaps = 121/1555 (7%) Query: 806 IYPYFASLYGMGKVIREEYSGLHCRCIDC-----DESAPVRELADEVFRPSDHYQIAIRE 860 ++P A L+G+ KVI +E L C +D S V +L E+ D +A R Sbjct: 1185 VFPEKAPLFGLAKVISQENPKLQCFSLDLATEGRSTSQLVGQLLAEIRCNRDDTLVAYR- 1243 Query: 861 GKKYYPQLTPVDLDAFDNSMTGFKEXXXXXXXXXXXXXXXXXAQHIALKHKVKLVLISRS 920 G + P++ D+D +E ++++A + V LVLI+RS Sbjct: 1244 GNRIVPEMNRCDIDKVPKRPVEIRENGVYLIAGGTGKLGLAFSKYLAAQKNVTLVLINRS 1303 Query: 921 RLPARESWEELIQSAQEPDERAALIHSLK---HLESNGSQLFTYSADVAELDELSPVISR 977 LP W+ +Q PD AA LK LE G+Q+ Y+ADV++ ++ + + Sbjct: 1304 PLPPNHEWQARLQ---HPDCSAAEARKLKALLELEEMGAQVVCYAADVSDRQQMEDISEQ 1360 Query: 978 ITSQLGKIDGIIHAAGLPGSGLLIEKDGQSFAASVAAKIKGTRHLHLLTRDNPPDFLLLF 1037 + ++ G I+GII +A + +K F + AK+ GT L + DF ++F Sbjct: 1361 VRARYGPINGIIQSAAHITFETIQKKKFSDFQNGLKAKLAGTVILDQIAEPEHLDFFVIF 1420 Query: 1038 SSIASVVGGIYLGDYVAGNSYLDAFSGLLAGHTR-LISINWTTWMNTGMAKNTGGSLDVA 1096 SS+AS+ GG DYV+ N +LDA+S + R I++NW + G Sbjct: 1421 SSLASIWGGATGSDYVSSNCFLDAYSAARSRTGRPTIALNWYAF---------EGITGPG 1471 Query: 1097 FRSILPRH-ALHAFDQILGKKINNIVVGSIQFNNDLFWNRPLPVSLAPAI---------R 1146 F +P A+ AF L + ++++G W L V L +I R Sbjct: 1472 FIGYMPMDGAIQAFAASLSCQAEHLIIGQFDLQVLKEWAPSLKVKLGDSIFASEKSRKER 1531 Query: 1147 EQIKHPEAEIDVRLTGRAD-QSYTEIEQQIARIWGNLFQMPNIDIQDNFYELGGTSIMGI 1205 E + V L+GR + YT +E + +IW ++ + I D+F+ LGG S++ I Sbjct: 1532 EVPTEVTMQNRVVLSGREEGDHYTSLELALGQIWSDVLGYTELSIDDDFFRLGGDSLLAI 1591 Query: 1206 KIANRINEQYRVTMTIQDVFTHLTVASLGKLVEQKLGTKTEAGAVNKQEVEYAKTSMPLS 1265 I +R+++Q + +TI ++F T+ L L+ E AV+ V + + P + Sbjct: 1592 GIVSRVSKQMQKEITITNLFQTPTIRQLAVLM-----APNEETAVSAIPVAEYREAYPAT 1646 Query: 1266 HAQRRIWFLQKMNPDLVAYNLPFIRYFDMAIDLELLQQAASFLAGRHLLMRTKYVLKDGN 1325 +Q+RI+ L++M VAYN+P + + +D E ++A L RH +RT + + DG Sbjct: 1647 SSQQRIYVLEQMQEGAVAYNIPTVMMLEGELDKEAFERAFISLVQRHESLRTSFSIVDGA 1706 Query: 1326 PVQEVLPA--YVPAVQSIDAAGQSDPELFVKMNIHQQKMKPFNLEMPPY-RIYLYTISDE 1382 +Q V P+ + A +D ++D + V +Q ++PF+L P R L I Sbjct: 1707 LMQTVQPSVDFTLAYSEVD---ENDAKRTV-----EQFIRPFDLSKAPLVRGMLIRIDVN 1758 Query: 1383 RACLYINFHHILTDGWSIDIYYRELFSLYQAFLHQQPPRLPEVKEDYFDWILEQKAWEES 1442 + L + HHI++DG SI+I RE F LYQ LPE++ Y D+ + Q + Sbjct: 1759 KHLLLFDMHHIISDGVSINILIREFFQLYQGL------ELPELRIQYKDYSVWQTEQLGN 1812 Query: 1443 EAFVEHEQFWLKELAKPLPVLSLPSDHKAPAVQTYRGSFHKFTISGELYRKLKAHLETQQ 1502 E+FW EL LPVL+LP+D+ P+VQ++ G F I E+ +K+ A + Sbjct: 1813 GVLAAQEKFWQGELDGELPVLNLPTDYPRPSVQSFDGDVLTFEIPQEMTQKILALAKNNG 1872 Query: 1503 ITANNFLLSAYFLLLHNLSQEQDIIIGVPASGRNEQKWESVAGIFINTLCIRIHFQGITT 1562 T LL A ++L + E+DIIIG P +GR+ E++ G+F+NTL +R + T Sbjct: 1873 ATLYMTLLGALSIMLSKYAGEEDIIIGSPVAGRHHADLENIVGVFLNTLAMRNFPRSDRT 1932 Query: 1563 FMELQDAVKHKVWSAMDKAQYPFDLLVEKVNPDRDLSRNPIYNVLFQFYDKLYLENEG-- 1620 + VK + +A+ A YPF++LV+++ +D +RNP+++V+F L+N G Sbjct: 1933 VADFLQEVKERALAALSHADYPFEMLVDRLTLPKDTARNPLFDVMF------ILQNTGDA 1986 Query: 1621 ----------ISP---------FELSCLAQETNQQIEISFEYNSDMYTDSTISRFAGYFL 1661 +SP F+L+ E Q++ + EY++ +++ TI+ + +F Sbjct: 1987 KGSMSANGLTLSPYPFEQRSAQFDLTFDIIEREQRLIVDIEYSNKLFSKETIASMSTHFQ 2046 Query: 1662 NIIGQVVDKPXXXXXXXXXXXXXXXXXXXSRFQGEQADLEDGQTIHGRFEAQVQKNPHAI 1721 I+ Q+V+ P ++ + +T+ FE +K+P+A+ Sbjct: 2047 KILEQMVEDPEQLIGKMSMLAAEERMLLIDQWNDTSLEYSREKTVVQLFEEVAEKHPNAL 2106 Query: 1722 ALVYEEQQMTFQEVNGKANQLAWMLTGSGVQRNTPVGIFVDRSFSSVIGILAILKAGGAY 1781 A+ ++++T+ E+N +ANQ+A ++ GV +T VG+ +RS ++G++AILKAG A+ Sbjct: 2107 AVSCGDEKVTYAELNKRANQVARLMKQHGVTADTCVGLLTNRSVEMMVGLMAILKAGAAF 2166 Query: 1782 VPLDPGYPEDRIAYILAHSGAKWLLTENRYLQSVAAFAHEEGIQIINLSPVKEQSAVSQM 1841 VP+DP YPE+RI+Y+L +S +LT + + K+ +V ++ Sbjct: 2167 VPIDPHYPEERISYVLENSMTPLVLTHDSLAE-------------------KQWGSVVRV 2207 Query: 1842 YLAD--YEDELSRENPRTGGHGPDRMYIMYTSGSTGKPKGVLVTHSNVLNFVTWSIGE-L 1898 + D E E P G D Y++YTSGSTGKPKGV+V H N+++F + IGE + Sbjct: 2208 DVNDPRIETEDDSNLPPQATPG-DLAYVIYTSGSTGKPKGVMVEHGNLMSFCS-GIGEHI 2265 Query: 1899 QLQPKDALLLVTSISFDISVFEIFAALLSGSRLCIASMEHLKDTECLLAYMEAQHITIWH 1958 D +L VT+ISFDI + E L G + IA+ + D + L + + IT Sbjct: 2266 DFASADKMLAVTTISFDIFLLETIVPLTKGMTVVIATEQQQADPQVLKELILQEEITFLQ 2325 Query: 1959 SVPSLMVQLMTLLRHHPGRYRHSPVLQQLRHLMLGGEAWSTSLAASLRETFPQAEIRNMY 2018 PS +L +L + L L+ +++GGEA S SL LR T +A + N+Y Sbjct: 2326 LTPS---RLQLMLEEKSNLH----ALDSLKAILIGGEALSKSLFQRLR-TQTKARLYNLY 2377 Query: 2019 GPTEATIWVSSYKPGPEIDESHPVMLIGRPIANNRLIILDQYGNVCPPGVAGEIYIAGNN 2078 GPTE TIW S+ + + +E + IG P+ N ++ ILD++ V P + G++YIAG+ Sbjct: 2378 GPTETTIW-STVQDLTDAEE----VTIGAPLPNTQVYILDEHLQVQPMKINGDLYIAGDG 2432 Query: 2079 VTQGYYNDEEKTRMAFIPQ--SNGQIFYKTGDSGRYLPEGNVEFTGRRDQLVKVRGYRIE 2136 VT+GY+ T +IP GQ YKTGD R++P+G +E+ GR D KVRGYRIE Sbjct: 2433 VTRGYFGQPTLTAERYIPNPFQPGQRMYKTGDLARWMPDGRIEYVGRSDFQCKVRGYRIE 2492 Query: 2137 LGEIEQALKELTSLQQIAVTAVKDGETSKIVCLYTGDQPVPQNQLKDAVRKRLPEYMIPA 2196 LGEIE AL + + + V+ + Y + + ++L+ + K LP+YMIP Sbjct: 2493 LGEIETALSQHPDITEAVVSVRDTASNPYLAAYYMAKRTLDSDELRAMLSKSLPDYMIPH 2552 Query: 2197 QFFHVERFLLTPNGKMDWRSMEKFVRETPGSIEAAGIRNEVDKKLSEIWKKLLGIPAVGI 2256 + H+ + LTPNGK+D +S+ + IE ++++++ IW+++L VG+ Sbjct: 2553 FYTHMNMWPLTPNGKLDRKSLPEPDSLQDKHIEYQAPATRLEEQVAGIWQEVLKREMVGM 2612 Query: 2257 QENFFDIGGNSLLVVQMQGMIQQEFFQDIPMMDLFKYTSIEKISDYLQEHTVKVS 2311 Q+NFF IGGNSLL+VQ+ ++Q + + + DLF + ++ ++++L+ + ++ Sbjct: 2613 QDNFFQIGGNSLLLVQVHAKLEQLYPGRVRIADLFAHPTLSSLTNFLKNTALDLA 2667 Score = 468 bits (1204), Expect = e-129, Method: Compositional matrix adjust. Identities = 256/652 (39%), Positives = 385/652 (59%), Gaps = 13/652 (1%) Query: 7 INDHILQLLKSGNLNQEMAVSILEKVNRSSDVKRQDIAVIGIACRVPGADTPRRFWGNLL 66 + +IL+ + + L+++ A+ +L++++ ++ RQDIA+IG+ACR PGA++ +W NL Sbjct: 4 LKKYILEQVAAHRLHEKEALPLLKELSSANVNTRQDIAIIGMACRFPGANSLEEYWNNLK 63 Query: 67 GRVNSIGAFPEERLQDLSPFIPELEELLAHANHQAGYLEQIAHFDHPFFRIGGKEAMAME 126 +SI P R D+ E + GYLE + FDH FF I EA M+ Sbjct: 64 QGHDSISDIPAARRPDVERVAREFFNDTDFQYERMGYLEHVDLFDHAFFEISPAEARTMD 123 Query: 127 PYQRLFLETAYHAIEDAGYGGDALKHSNTGVFVGLETAYQSHYRALLEHEDISSLTGSLV 186 PYQR+FLE A+ E AGY + S TGVF+G +S Y+ +L++ D SSL G++ Sbjct: 124 PYQRMFLELAWETFEHAGYSEKMISGSPTGVFLGY-CDNESQYQRVLKNVDSSSLAGNVA 182 Query: 187 GLLANRISYFLDLRGPALVVNTACSSGLVALHQACLALMNKECETALVGGVNLMVIPQAT 246 ++A+RISY L+L GP+ ++NT+CSS LVALHQAC A+ N +C ALVGGVNL + P Sbjct: 183 AIIASRISYLLNLSGPSQLINTSCSSSLVALHQACQAIGNNDCRMALVGGVNLSLFPIQQ 242 Query: 247 GKLNDLETSLGQVKAFDKDADGTIWSEGITALLVKPLEKALKDRDPVYAVIKASGVNADG 306 + + + KAFD ADGT+W EG+ A+L+K ++A++D D ++AVIK++ VN DG Sbjct: 243 DTDFGIVSVDRKTKAFDDFADGTVWGEGLGAVLLKSYDQAVRDNDYIHAVIKSTAVNCDG 302 Query: 307 ASNGLTAPNPEAETGLFIRTWEKAKIDPLSISYVEAHGTGTLLGDSIELQAINDAFKKYT 366 S +TAPN +++ L TWE+A+I+P SISY+EAHGTGT LGD +E++ I AF+K + Sbjct: 303 RSTSITAPNAISQSALLRTTWERARINPESISYIEAHGTGTRLGDPVEIEGIMHAFQKVS 362 Query: 367 NTPHICGIGSVKTNIGHTVAASGLASLLKVILSLKHKKIPPSLNYQSPN---PFIDADHS 423 C IGSVK+NIGHT+AASG+A ++K +L +KH++IPP+L+ + PN PFID S Sbjct: 363 KRKQFCAIGSVKSNIGHTIAASGVAGIIKTVLMMKHRQIPPTLHVKRPNTLIPFID---S 419 Query: 424 AIYVNTEVKDW--ERRDTARRAGVNSFGFSGTNCHVVVEEAPEMNHQAGEGSSPFHFLTL 481 +Y+N +K W E RRAG+++FG SGTN HV++EE P AG S + +TL Sbjct: 420 PVYINDVLKAWDVEADQPVRRAGISAFGLSGTNAHVILEEPPGREAIAGSESGNY-LITL 478 Query: 482 SAGSTHGLARLIQAYYAFLQDNDQIDLEDLCYTANTGRGHSDSRAAFVFATRDELMKQLA 541 SA ++ L L++ Y FL + L D+C TAN GRGH R AFV ++++ ++++ Sbjct: 479 SAKTSESLWDLLEKYQTFLSGPSEHSLLDMCATANMGRGHYRYRLAFVINSKEDFLQKI- 537 Query: 542 NADXXXXXXXXXXXXXXXXXVQREDLLTAAEELEPDRQNLQLTYE-KLAERYVGGFSVDW 600 + V L + E P + + ++A++YV G ++W Sbjct: 538 HCLCAGERMEDGAPLVDGNQVFYGVLNSRGESSSPISMQIDSSDPVEMAKQYVRGVPINW 597 Query: 601 AALY-PQKRQKLNLPGYPFEKIKLWPTAAVKSGSALEKQPDFQDTANPHEET 651 Y P K +K+ LP Y F K + W + + +E+ A ET Sbjct: 598 LEYYRPVKWKKVPLPTYSFAKTRHWVQTDQPANNMVEQSNAVASVAAQENET 649 >C2XEJ7.1 C2XEJ7_BACCE Putative uncharacterized protein Length = 2534 Score = 652 bits (1682), Expect = 0.0, Method: Compositional matrix adjust. Identities = 389/1215 (32%), Positives = 652/1215 (53%), Gaps = 75/1215 (6%) Query: 1129 NDLFWNRPLPVSLAPAIREQIKHPEAEIDVRLTGRADQ---SYTEIEQQIARIWGNLFQM 1185 N +F PVS P+ + K E +I L Q +E E+++A+ W + + Sbjct: 943 NYVFHLESFPVS--PSGKLDRKKLELQIPSLLENMQKQYVPPISETEKRLAKTWAEILNL 1000 Query: 1186 PNIDI--QDNFYELGGTSIMGIKIANRINEQYRVTMTIQDVFTHLTVASLGKLVEQKLGT 1243 I +D+F++LGG S++ +++ N+I +++ + + I+D+F H T+ASL +++ + Sbjct: 1001 GKYRISREDDFFKLGGHSLIAVQVLNQIQKEFHLKIEIRDIFEHTTIASLSAYIDKLMAV 1060 Query: 1244 KTEAGAVNKQEVEYA-KTSMPLSHAQRRIWFLQKMNPDLVAYNLPFIRYFDMAIDLELLQ 1302 + Q ++ A K S LS AQ+RIWFL K N Y+ P Y + +++ ++LQ Sbjct: 1061 NHDREEQEMQVLKVADKESYQLSSAQKRIWFLNKYNAINRVYDTPLHIYIEPSLNKDILQ 1120 Query: 1303 QAASFLAGRHLLMRTKYVLKDGNPVQEVLPAYVPAV--QSIDAAGQSDPELFVKMNIHQQ 1360 FL RH ++RT ++ ++G P Q +L + + I+ + + + +++ I+Q Sbjct: 1121 DTIRFLVERHEMLRTVFIERNGEPRQVILSSIAIDLIHDEIEHMSKKEQQEYIRTTINQT 1180 Query: 1361 KMKPFNLEMPP-YRIYLYTISDERACLYINFHHILTDGWSIDIYYRELFSLYQAFLHQQP 1419 PF+LE P +RI ++ ++ +++ LYIN HHI+TD WS+ EL +Y AF ++ Sbjct: 1181 DHTPFDLEKGPLFRIRIFNLNKKKSYLYINLHHIITDEWSVRNLLDELMKVYIAFAKRRN 1240 Query: 1420 PRLPEVKEDYFDWILEQKAWEESEAFV----EHEQFWLKELAKPLPVLSLPSDHKAPAVQ 1475 P LP + Y D+ WE+++ + + +W+ ELA PLP+L+LP D Sbjct: 1241 PELPTISNRYVDY----AEWEQAQLNLGRWDTEKSYWMAELAAPLPILNLPLDFSRNRQS 1296 Query: 1476 TYRGSFHKFTISGELYRKLKAHLETQQITANNFLLSAYFLLLHNLSQEQDIIIGVPASGR 1535 T +G+ + + E+ LK E + ++ L+AY LLH L+ ++DII+G P GR Sbjct: 1297 TNKGTVFEMKLDNEMKESLKQVCEQENVSMYMLFLAAYIQLLHYLTDQKDIIVGTPVVGR 1356 Query: 1536 NEQKWESVAGIFINTLCIRIHFQGITTFMELQDAVKHKVWSAMDKAQYPFDLLVEKVNPD 1595 N Q++E + G F+NTL IR + +L V+ K ++ YPFD ++E++NPD Sbjct: 1357 NHQEFEQIQGFFVNTLAIRTQLNDVKNLTQLLQVVREKCLNSFQNQSYPFDKVIEQINPD 1416 Query: 1596 RDLSRNPIYNVLFQFYDKLYLENEG-----------ISPFELSCLAQETNQQIEISFEYN 1644 R NPI++ +F + + +++ IS F++S +E + +SFEY+ Sbjct: 1417 RSFGNNPIFSTMFSYQKNILQQHDAYKLQLLPNKQDISKFDISLAVEEGLDYVGVSFEYD 1476 Query: 1645 SDMYTDSTISRFAGYFLNIIGQVVDKPXXXXXXXXXXXXXXXXXXXSRFQGEQADLEDGQ 1704 +++ + +I+RF L I+ + + + Q Q Sbjct: 1477 INLFKEESINRFTQNLLTILDAFIHR-RTVAFENLVFLSQEEESLYKKVNHTQRPYPYFQ 1535 Query: 1705 TIHGRFEAQVQKNPHAIALVYEEQQMTFQEVNGKANQLAWMLTGSGVQRNTPVGIFVDRS 1764 I +F QV + + IA+ E + +T++++N +NQ+A L G++R V IF+DRS Sbjct: 1536 NIQEQFYMQVDRQSNRIAIATETESLTYRQLNMSSNQVAQHLLEKGIKRGDKVAIFLDRS 1595 Query: 1765 FSSVIGILAILKAGGAYVPLDPGYPEDRIAYILAHSGAKWLLTENRYLQSVAAFAHEEGI 1824 +S++ +L ILKAG AY+P+D YPEDRI YI+ S A ++T N++ +H Sbjct: 1596 MNSIVSMLGILKAGAAYIPIDVKYPEDRINYIVRDSEACRIITSNKFK------SH---- 1645 Query: 1825 QIINLSPVKEQSAVSQMYLADYEDELSRENPRTGGHGPDRM-YIMYTSGSTGKPKGVLVT 1883 +N+S K S + +Y D++ N PD + Y++YTSGSTGKPKG L+T Sbjct: 1646 --LNVSDYK-VSIIEDIYRTTINDDVKILNK------PDDLAYVIYTSGSTGKPKGTLLT 1696 Query: 1884 HSNVLNFVTWSIGELQLQPKDALLLVTSISFDISVFEIFAALLSGSRLCIASMEHLKDTE 1943 H VLN V W Q+ P D + S SFD SV EIF+ LL+G+ L + S E T Sbjct: 1697 HKGVLNLVEWRNEVFQISPNDKVTQFYSHSFDSSVSEIFSTLLNGAELYLLSDEQRYSTV 1756 Query: 1944 CLLAYMEAQHITIWHSVPSLMVQLMTLLRHHPGRYRHSPVLQQLRHLMLGGEAWSTSLAA 2003 ++ TI +P++ ++ P S ++ LR +++GGEA ST+ Sbjct: 1757 AYAQAIQETQATI-SDLPTVFFNELSTSLTKPD----SEKIRSLRFIIMGGEAASTNAIR 1811 Query: 2004 SLRETFP-QAEIRNMYGPTEATIWVSSY-KPGPEIDE----SHPVMLIGRPIANNRLIIL 2057 S + TF Q ++ N YGPTEAT+ Y P E D S P IG PI+N +++IL Sbjct: 1812 SWQNTFKNQVQLVNEYGPTEATVSAMYYFIPVLEGDNNLLGSIP---IGIPISNTKVLIL 1868 Query: 2058 DQYGNVCPPGVAGEIYIAGNNVTQGYYNDEEKTRMAFI----PQSNGQIFYKTGDSGRYL 2113 + Y CP G GE+YI + QGY+ EEKT+ AFI + N + Y+TGD R+L Sbjct: 1869 NSYMQHCPVGAMGELYIESVGLAQGYWKQEEKTKQAFISNPFSEDNSKRLYRTGDLARWL 1928 Query: 2114 PEGNVEFTGRRDQLVKVRGYRIELGEIEQALKELTSLQQIAVTAVKDGETSKIVCLYTGD 2173 GN+EF GR+D+ VK+RG+RIELGEIE A+ +L + Q VT +DG ++ Sbjct: 1929 SNGNIEFMGRKDKQVKIRGHRIELGEIEDAMLQLEGISQAVVTQTEDGMLLQVYYKTVDG 1988 Query: 2174 QPVPQNQLKDAVRKRLPEYMIPAQFFHVERFLLTPNGKMDWRSMEK--FVRETPGSIEAA 2231 + +N+L + LPEYM+P + HV +T NGK+D+ + K F E + Sbjct: 1989 IGIEKNKLALHLSNVLPEYMVPKYYSHVLEIPITANGKIDFEKLPKIEFGHEQKDECKLK 2048 Query: 2232 GIRNEVDKKLSEIWKKLLGIPAVGIQENFFDIGGNSLLVVQMQGMIQ-QEFFQDIPMMDL 2290 + +V K ++++W ++L + ++G++++FF++GG+SL V M +++ + + ++ + D Sbjct: 2049 P-QTKVQKDITKVWSEVLNVKSIGLKDDFFNLGGHSLKV--MPALVKLKPLYPNLKIQDF 2105 Query: 2291 FKYTSIEKISDYLQE 2305 FKY +IEK++ +++E Sbjct: 2106 FKYRTIEKLASHIEE 2120 Score = 408 bits (1048), Expect = e-111, Method: Compositional matrix adjust. Identities = 293/1079 (27%), Positives = 518/1079 (48%), Gaps = 85/1079 (7%) Query: 1267 AQRRIWFLQKMNPDLVAYNLPFIRYFDMAIDLELLQQAASFLAGRHLLMRTKYVLKDGNP 1326 Q +W +M + N P I + +E+L++A + + H +RT + +D Sbjct: 19 GQEALWIAHQMEIEKGMNNEPIIIKLKGKLQIEVLKKALTVIVQSHPALRTIFKKRD-EK 77 Query: 1327 VQEVLPAYVP---AVQSIDAAGQSDPELFVKMNIHQQKMKPFNLEMPP-YRIYLYTISDE 1382 +++++ V ++ + A ++ + +K + + F+LE P ++ ++ S++ Sbjct: 78 IKQLIRKNVEFDIPIKDLTAFKNTEQKSILKNFLESIVNEKFSLEEGPLFKFHIIKFSED 137 Query: 1383 RACLYINFHHILTDGWSIDIYYRELFSLYQAFLHQQPPRLPEVKEDYFDWILEQKAWEES 1442 L++ FHHI+ DGWS+ ++ R+L + Y L Q E + Y + + ++ + +S Sbjct: 138 TFVLHLMFHHIIYDGWSLGVFIRQLSNTYGELL--QGNTNVEFESPYKNLVEYEEGFIDS 195 Query: 1443 EAFVEHEQFWLKELAKPLPVLSLPSDHKAPAVQTYRGSFHKFTISGELYRKLKAHLETQQ 1502 + E +W L L P D + Y I+ +L+ +++ + Sbjct: 196 AIYKEGSSYWKDYLQGELTPTEFPIDFNKMNEKRYTDKNISKNINSDLFYQIQCFAKKNN 255 Query: 1503 ITANNFLLSAYFLLLHNLSQEQDIIIGVPASGRNEQKWESVAGIFINTLCIRIHFQGITT 1562 I+ +LS Y LLH ++ ++II+G+P + R + G F+NT+ IRI + T Sbjct: 256 ISIYRVMLSTYCTLLHQMTNAEEIIVGIPINTRPHTEERDTFGYFVNTVPIRITIEKGET 315 Query: 1563 FMELQDAVKHKVWSAMDKAQYPFDLLVEKVNPDRDLSRNP--IYNVLFQ----------- 1609 F + + V + A+ P+ +V+ +N + + + N IY+ F Sbjct: 316 FKGILNKVNKSIHLAITYKHNPYSHIVKDLNLNTNTNTNHNMIYSTAFNTMKIPELKIPD 375 Query: 1610 FYDKLYLENEGISPFELSCLAQ----ETNQQIEISFEYNSDMYTDSTISRFAGYFLNIIG 1665 + + + ++PF ++ ET +IEI +YNS +Y +IS ++ ++ Sbjct: 376 IESTVLTDCKRVNPFNMTWRIMRYEGETENKIEI--DYNSALYKPESISDLVERYIYLLQ 433 Query: 1666 QVVDKPXXXXXXXXXXXXXXXXXXXSRFQGEQADLEDGQTIHGRFEAQVQKNPHAIALVY 1725 +++ K + + +T+ + Q K+P+ IA+ Sbjct: 434 KLM-KNVNEPIHSLDLLLKKDHRLYNEMNSNALTYPNSKTLDQLIDLQTLKSPNQIAISM 492 Query: 1726 EEQQMTFQEVNGKANQLAWMLTGSGVQRNTPVGIFVDRSFSSVIGILAILKAGGAYVPLD 1785 ++ +T+ E+ ++NQ+A L + +++ V I ++R +++ IL ILK+GG YVP+D Sbjct: 493 GDKSITYYELQQRSNQIANYLRENDLKKGQRVSITMEREIDTIVWILGILKSGGVYVPID 552 Query: 1786 PGYPEDRIAYILAHSGAKWLLTENRYLQSVAAFAHEEGIQIINLSPVKEQSAVSQMYLAD 1845 P +PE RI YIL S ++ ++T+ Y V F A+ +YL D Sbjct: 553 PKFPEKRIEYILKDSESQMIITKREYRGLVERF------------------AIHTIYLED 594 Query: 1846 YEDELSRENPRTGGHGPDRMYIMYTSGSTGKPKGVLVTHSNVLNFVTWSIGELQLQPKDA 1905 + S EN + D YI+YTSGSTG PKGV+V H V+N I L +D Sbjct: 595 FHYVNSIENIASTHTIEDAAYIIYTSGSTGLPKGVVVPHKGVVNLSYSVINTFHLGKEDV 654 Query: 1906 LLLVTSISFDISVFEIFAALLSGSRLCIASMEHLKDTECLLAYMEAQHITIWHSVPSLMV 1965 L +I FD S+ EIF LL G R+ + S + E + + IT L Sbjct: 655 FLQFATIIFDASIMEIFPILLCGGRMHLISDIEKRSAEEFINVSQKNGIT----NVVLPT 710 Query: 1966 QLMTLLRHHPGRYRHSPVLQQLRHLMLGGEA--------WSTSLAASLRETFPQAEIRNM 2017 L+ P L ++ L +GGE W + L + + N Sbjct: 711 AFFKLIADMPKEMLLK--LNSVKRLFVGGETLPAESVRKWQSKLGLKI-------PVLNA 761 Query: 2018 YGPTEATIWVSSYKPGPEIDESHPVMLIGRPIANNRLIILDQYGNVCPPGVAGEIYIAGN 2077 YGPTE T+ + Y+ EI + + IG+PIAN+ + ++ + +CP GV GE++I G+ Sbjct: 762 YGPTETTVCATMYEVNGEIQKEISSIPIGKPIANSEVFVVSPFNTLCPSGVVGELFIGGD 821 Query: 2078 NVTQGYYNDEEKTRMAFIPQ----SNGQIFYKTGDSGRYLPEGNVEFTGRRDQLVKVRGY 2133 V GY N +EKT AFI ++ + Y+TGD R LP GN+EF GR+D VK+RGY Sbjct: 822 GVANGYLNQKEKTEEAFISSDKSYNHDKKMYRTGDLVRLLPNGNLEFIGRKDNQVKIRGY 881 Query: 2134 RIELGEIEQALKELTSLQQIAVTAVKDGETSKIVCLYTG--DQPVPQNQLKDAVRKRLPE 2191 RIEL EIE L + ++ V ++ KIV Y + + Q LK + + LP+ Sbjct: 882 RIELDEIEGTLFKHPEVRDAVVFTYQN---DKIVSFYLSKDNTELKQEALKTFLSESLPD 938 Query: 2192 YMIPAQFFHVERFLLTPNGKMDWRSMEKFVRETPGSIEAAGIR-----NEVDKKLSEIWK 2246 +M+P FH+E F ++P+GK+D + +E + P +E + +E +K+L++ W Sbjct: 939 FMMPNYVFHLESFPVSPSGKLDRKKLE---LQIPSLLENMQKQYVPPISETEKRLAKTWA 995 Query: 2247 KLLGIPAVGI--QENFFDIGGNSLLVVQMQGMIQQEFFQDIPMMDLFKYTSIEKISDYL 2303 ++L + I +++FF +GG+SL+ VQ+ IQ+EF I + D+F++T+I +S Y+ Sbjct: 996 EILNLGKYRISREDDFFKLGGHSLIAVQVLNQIQKEFHLKIEIRDIFEHTTIASLSAYI 1054 >O30409.1 TYCC_BREPA Tyrocidine synthetase 3 ATP-dependent asparagine adenylase ATP-dependent glutamine adenylase ATP-dependent tyrosine adenylase ATP-dependent valine adenylase ATP-dependent ornithine adenylase ATP-dependent leucine adenylase Length = 6486 Score = 639 bits (1647), Expect = e-180, Method: Compositional matrix adjust. Identities = 394/1156 (34%), Positives = 608/1156 (52%), Gaps = 72/1156 (6%) Query: 1170 EIEQQIARIWGNLFQMPNIDIQDNFYELGGTSIMGIKIANRINEQYRVTMTIQDVFTHLT 1229 E E ++A IW ++ + I + D+F+ELGG S+ + + + + ++V + ++ +F T Sbjct: 2006 EWEAKLAAIWESVLGVEPIGVHDHFFELGGHSLKAMHVISLLQRSFQVDVPLKVLFESPT 2065 Query: 1230 VASLGKLVEQ-KLGTKTEAGAVNKQEVEYAKTSMPLSHAQRRIWFLQKMNPDLVAYNLPF 1288 +A L LV + GT T V KQE P+S AQ+R++ LQ+M ++YN+P Sbjct: 2066 IAGLAPLVAAARKGTYTAIPPVEKQEY------YPVSAAQKRMFILQQMEGAGISYNMPG 2119 Query: 1289 IRYFDMAIDLELLQQAASFLAGRHLLMRTKYVLKDGNPVQEVLPAYVPAVQSIDAAGQSD 1348 Y D +D E LQQA L RH +RT + G VQ V A+ S A +++ Sbjct: 2120 FMYLDGKLDTERLQQALKSLVQRHESLRTSFHSVQGETVQRVHDDVDLAI-SFGEATEAE 2178 Query: 1349 PELFVKMNIHQQKMKPFNLEMPPY-RIYLYTISDERACLYINFHHILTDGWSIDIYYREL 1407 I +Q ++PF+L P R L ++ ER ++ HHI+ DG SI + E Sbjct: 2179 TR-----QIAEQFIQPFDLGTAPLLRAGLIKLAPERHLFMLDLHHIVVDGVSIGLLIEEF 2233 Query: 1408 FSLYQAFLHQQPPRLPEVKEDYFDWILEQKAWEESEAFVEHEQFWLKELAKPLPVLSLPS 1467 LY LP ++ Y D+ Q+ W ++E F E E +WL +PVL+LP+ Sbjct: 2234 AQLYHG------EELPALRIQYKDFAKWQQDWFQTEEFAEQEAYWLNTFTGEIPVLNLPT 2287 Query: 1468 DHKAPAVQTYRGSFHKFTISGELYRKLKAHLETQQITANNFLLSAYFLLLHNLSQEQDII 1527 D+ P+V+++ G F L ++L + T LL+AY +LL S+++DII Sbjct: 2288 DYPRPSVKSFAGDRFVFGSGTALPKQLHQLAQETGTTLYMVLLAAYNVLLSKYSRQEDII 2347 Query: 1528 IGVPASGRNEQKWESVAGIFINTLCIRIHFQGITTFMELQDAVKHKVWSAMDKAQYPFDL 1587 +G P +GR+ + ES+ G+F+NTL +R G TF + VK A + YP D Sbjct: 2348 VGAPTAGRSHAETESIVGMFVNTLALRNEPAGGKTFRDFLAEVKINTLGAFEHQDYPLDE 2407 Query: 1588 LVEKVNPDRDLSRNPIYNVLFQFYD----KLYLENEGISP---------FELSCLAQETN 1634 LV+K++ RDLSRNP+++ +F + +E I+P F+LS A E N Sbjct: 2408 LVDKLDMQRDLSRNPLFDTVFILQNMEQKPFEMEQLTITPYSAEVKQAKFDLSLEAYEEN 2467 Query: 1635 QQIEISFEYNSDMYTDSTISRFAGYFLNIIGQVVDKPXXXXXXXXXXXXXXXXXXXSRFQ 1694 +I S +Y++ +++ TI + A +F+ I+ V+ +P F Sbjct: 2468 AEIIFSLDYSTKLFSRETIEKIATHFIQILRAVIAEPEMPLSEITMLTEAEKQRLLVDFN 2527 Query: 1695 GEQADLEDGQTIHGRFEAQVQKNPHAIALVYEEQQMTFQEVNGKANQLAWMLTGSGVQRN 1754 G D +T+ FE Q +K+P A A+ Q +++QE+N +ANQLA L GVQ + Sbjct: 2528 GAHKDFPQNKTLQALFEEQAEKSPQATAVEISGQPLSYQELNERANQLAATLRERGVQPD 2587 Query: 1755 TPVGIFVDRSFSSVIGILAILKAGGAYVPLDPGYPEDRIAYILAHSGAKWLLTENRYLQS 1814 PVGI +RS V+GILAILKAGGAYVP+DP YPE+R+AY+L A+ +LT+ Sbjct: 2588 QPVGIMANRSVEMVVGILAILKAGGAYVPIDPEYPEERVAYMLTDCQARLVLTQKHLGAK 2647 Query: 1815 VAAFAHEEGIQIINLSPVKEQSAVSQMYLADYEDE-LSRENPRTGGHGPDRMYIMYTSGS 1873 + + E +YL D + + R N + D YI+YTSG+ Sbjct: 2648 LGSSVTAEC-----------------LYLDDESNYGVHRSNLQPINTASDLAYIIYTSGT 2690 Query: 1874 TGKPKGVLVTHSNVLNFVTWSIGELQLQPKDALLLVTSISFDISVFEIFAALLSGSRLCI 1933 TGKPKGV+V H ++N V W E Q++ D LL S +FD V F +LSG+ + + Sbjct: 2691 TGKPKGVMVEHRGIVNNVLWKKAEYQMKVGDRSLLSLSFAFDAFVLSFFTPVLSGATVVL 2750 Query: 1934 ASMEHLKDTECLLAYMEAQHITIWHSVPSLMVQLMTLLRHHPGRYRHSPVLQQLRHLMLG 1993 A E KD L + A T+ VPSL ++ P R L+ + LG Sbjct: 2751 AEDEEAKDPVSLKKLIAASRCTLMTGVPSLFQAILEC--STPADIR------PLQTVTLG 2802 Query: 1994 GEAWSTSLAASLRETFPQAEIRNMYGPTEATIWVSSYK--PGPEIDESHPVMLIGRPIAN 2051 GE + L ++ P I N YGPTE+++ V++++ GP+ + IGRPIAN Sbjct: 2803 GEKITAQLVEKCKQLNPDLVIVNEYGPTESSV-VATWQRLAGPD-----AAITIGRPIAN 2856 Query: 2052 NRLIILDQYGNVCPPGVAGEIYIAGNNVTQGYYNDEEKTRMAFI--PQSNGQIFYKTGDS 2109 L I++QY + P GV GEI I G + +GY+N T F+ P + G+ YKTGD Sbjct: 2857 TSLYIVNQYHQLQPIGVVGEICIGGRGLARGYWNKPALTEEKFVSHPFAAGERMYKTGDL 2916 Query: 2110 GRYLPEGNVEFTGRRDQLVKVRGYRIELGEIEQALKELTSLQQIAVTAVKD--GETSKIV 2167 G++LP+G +E+ GR D+ VKVRGYRIE+GEIE AL L V +D G+ S + Sbjct: 2917 GKWLPDGTIEYIGRIDEQVKVRGYRIEIGEIESALLAAEKLTAAVVVVYEDQLGQ-SALA 2975 Query: 2168 CLYTGDQPVPQNQLKDAVRKRLPEYMIPAQFFHVERFLLTPNGKMDWRSMEKFVRETPGS 2227 +T D+ + +L + KRLP YMIPA F +++ LTPNGK+D +++ K + Sbjct: 2976 AYFTADEQLDVTKLWSHLSKRLPSYMIPAHFVQLDQLPLTPNGKVDKKALPKPEGKPVTE 3035 Query: 2228 IEAAGIRNEVDKKLSEIWKKLLGIPAVGIQENFFDIGGNSLLVVQMQGMIQQEFFQDIPM 2287 + N V+ KL+EIW+++LG+ +GI +NFF IGG+SL + + + +E+ ++P+ Sbjct: 3036 AQYVAPTNAVESKLAEIWERVLGVSGIGILDNFFQIGGHSLKAMAVAAQVHREYQVELPL 3095 Query: 2288 MDLFKYTSIEKISDYL 2303 LF +I+ ++ Y+ Sbjct: 3096 KVLFAQPTIKALAQYV 3111 Score = 599 bits (1545), Expect = e-168, Method: Compositional matrix adjust. Identities = 383/1158 (33%), Positives = 596/1158 (51%), Gaps = 77/1158 (6%) Query: 1171 IEQQIARIWGNLFQMPNIDIQDNFYELGGTSIMGIKIANRINEQYRVTMTIQDVFTHLTV 1230 +E ++A IW + + I I DNF+++GG S+ + +A +++ +Y+V + ++ +F T+ Sbjct: 3045 VESKLAEIWERVLGVSGIGILDNFFQIGGHSLKAMAVAAQVHREYQVELPLKVLFAQPTI 3104 Query: 1231 ASLGKLVEQKLGTKTEAGAVNKQEVEYAKTSMPLSHAQRRIWFLQKMNPDLVAYNLPFIR 1290 +L + V G +T EY P+S AQ+R++ L++ YN+P Sbjct: 3105 KALAQYVATS-GKETYVPIEPAPLQEY----YPVSSAQKRMYVLRQFADTGTVYNMPSAL 3159 Query: 1291 YFDMAIDLELLQQAASFLAGRHLLMRTKYVLKDGNPVQEVLPAYVPAVQSIDAA-GQSDP 1349 Y + +D + + A L RH +RT + +G PVQ V VQ + Q +P Sbjct: 3160 YIEGDLDRKRFEAAIHGLVERHESLRTSFHTVNGEPVQRVHEHVELNVQYAEVTEAQVEP 3219 Query: 1350 ELFVKMNIHQQKMKPFNL-EMPPYRIYLYTISDERACLYINFHHILTDGWSIDIYYRELF 1408 + + ++ F+L + P R+ L+ ++ +R ++ HHI++DG S I E Sbjct: 3220 TV-------ESFVQAFDLTKAPLLRVGLFKLAAKRHLFLLDMHHIISDGVSAGIIMEEFS 3272 Query: 1409 SLYQAFLHQQPPRLPEVKEDYFDWILEQKAWEESEAFVEHEQFWLKELAKPLPVLSLPSD 1468 LY+ LP + Y D+ + Q +S+ + EHE +WL + +PVL+LP+D Sbjct: 3273 KLYRG------EELPALSVHYKDFAVWQSELFQSDVYTEHENYWLNAFSGDIPVLNLPAD 3326 Query: 1469 HKAPAVQTYRGSFHKFTISGELYRKLKAHLETQQITANNFLLSAYFLLLHNLSQEQDIII 1528 P Q++ G F L L + Q T LL+AY +LL S ++DI++ Sbjct: 3327 FSRPLTQSFEGDCVSFQADKALLDDLHKLAQESQSTLFMVLLAAYNVLLAKYSGQEDIVV 3386 Query: 1529 GVPASGRNEQKWESVAGIFINTLCIRIHFQGITTFMELQDAVKHKVWSAMDKAQYPFDLL 1588 G P +GR+ E+V G+F+NTL +R + F + VK A YPF+ L Sbjct: 3387 GTPIAGRSHADIENVLGMFVNTLALRNYPVETKHFQAFLEEVKQNTLQAYAHQDYPFEAL 3446 Query: 1589 VEKVNPDRDLSRNPIYNVLFQF---------YDKLYLE----NEGISPFELSCLAQETNQ 1635 VEK++ RDLSRNP+++ +F D L LE G + F+L+ A E Sbjct: 3447 VEKLDIQRDLSRNPLFDTMFILQNLDQKAYELDGLKLEAYPAQAGNAKFDLTLEAHEDET 3506 Query: 1636 QIEISFEYNSDMYTDSTISRFAGYFLNIIGQVVDKPXXXXXXXXXXXXXXXXXXXSRFQG 1695 I + Y++ ++ +I R AG+FL ++ QVV F Sbjct: 3507 GIHFALVYSTKLFQRESIERMAGHFLQVLRQVVADQATALREISLLSEEERRIVTVDFNN 3566 Query: 1696 EQADLEDGQTIHGRFEAQVQKNPHAIALVYEEQQMTFQEVNGKANQLAWMLTGSGVQRNT 1755 A TI FE Q K P A+V + Q +T++E+N KANQLA +L +GV + + Sbjct: 3567 TFAAYPRDLTIQELFEQQAAKTPEHAAVVMDGQMLTYRELNEKANQLAHVLRQNGVGKES 3626 Query: 1756 PVGIFVDRSFSSVIGILAILKAGGAYVPLDPGYPEDRIAYILAHSGAKWLLTENRYLQSV 1815 VG+ DRS + GI+ ILKAGGAY+ LDP +P +R+AY+L G K +L + L V Sbjct: 3627 IVGLLADRSLEMITGIMGILKAGGAYLGLDPEHPSERLAYMLEDGGVKVVLVQKHLLPLV 3686 Query: 1816 AAFAHEEGIQIINLSPVKEQSAVSQMYLADYEDELSRE---NPRTGGHGPDRMYIMYTSG 1872 EG+ I L E+ L E NP D Y+MYTSG Sbjct: 3687 G-----EGLMPIVLE----------------EESLRPEDCGNPAIVNGASDLAYVMYTSG 3725 Query: 1873 STGKPKGVLVTHSNVLNFVTWSIGELQLQPKDALLLVTSISFDISVFEIFAALLSGSRLC 1932 STGKPKGV+V H NV V + +Q++ D ++ +I FD FEIF ALL G+ L Sbjct: 3726 STGKPKGVMVEHRNVTRLVMHT-NYVQVRESDRMIQTGAIGFDAMTFEIFGALLHGASLY 3784 Query: 1933 IASMEHLKDTECLLAYMEAQHI-TIWHSVPSLMVQLMTLLRHHPGRYRHSPVLQQLRHLM 1991 + S + L D E L ++ I T+W + P L QL + +P + LR L+ Sbjct: 3785 LVSKDVLLDAEKLGDFLRTNQITTMWLTSP-LFNQLS---QDNPAMF------DSLRALI 3834 Query: 1992 LGGEAWSTSLAASLRETFPQAEIRNMYGPTEATIWVSSYKPGPEIDESHPVMLIGRPIAN 2051 +GGEA S ++ P EI N YGPTE T + + Y +E P IG+PIAN Sbjct: 3835 VGGEALSPKHINRVKSALPDLEIWNGYGPTENTTFSTCYLIEQHFEEQIP---IGKPIAN 3891 Query: 2052 NRLIILDQYGNVCPPGVAGEIYIAGNNVTQGYYNDEEKTRMAFIPQ--SNGQIFYKTGDS 2109 + I+D P GV GE+ + G+ V +GY N E T F+P + G+ Y+TGD Sbjct: 3892 STAYIVDGNNQPQPIGVPGELCVGGDGVARGYVNKPELTAEKFVPNPFAPGETMYRTGDL 3951 Query: 2110 GRYLPEGNVEFTGRRDQLVKVRGYRIELGEIEQALKELTSLQQIAVTAVKDGETSKIVCL 2169 R+LP+G +E+ GR DQ VK+RGYRIELGEIE L + +++ V +++ K +C Sbjct: 3952 ARWLPDGTIEYLGRIDQQVKIRGYRIELGEIETVLSQQAQVKEAVVAVIEEANGQKALCA 4011 Query: 2170 Y-TGDQPVPQNQLKDAVRKRLPEYMIPAQFFHVERFLLTPNGKMDWRSMEKFVRE-TPGS 2227 Y +Q V +L++A+ K+LP YM+PA + +E+ LT NGK+D R++ + E T GS Sbjct: 4012 YFVPEQAVDAAELREAMSKQLPGYMVPAYYVQMEKLPLTANGKVDRRALPQPSGERTTGS 4071 Query: 2228 IEAAGIRNEVDKKLSEIWKKLLGIPAVGIQENFFDIGGNSLLVVQMQGMIQQEFFQDIPM 2287 A +N+ + KL +IW+++LGIPA+GI +NFF+IGG+SL + + + + F ++P+ Sbjct: 4072 AFVAA-QNDTEAKLQQIWQEVLGIPAIGIHDNFFEIGGHSLKAMNVITQVHKTFQVELPL 4130 Query: 2288 MDLFKYTSIEKISDYLQE 2305 LF +I +++ ++ E Sbjct: 4131 KALFATPTIHELAAHIAE 4148 Score = 598 bits (1542), Expect = e-168, Method: Compositional matrix adjust. Identities = 381/1203 (31%), Positives = 626/1203 (52%), Gaps = 83/1203 (6%) Query: 1132 FWNRPLPVSLAPAI----------------REQIKHPEAEIDVRLTGRADQSYTEIEQQI 1175 F R LP + P+ R+++ P + A Q+ EIE ++ Sbjct: 917 FLGRTLPSYMIPSFFIRLAEIPLTANGKVERKKLPKPAGAVVTGTAYAAPQN--EIEAKL 974 Query: 1176 ARIWGNLFQMPNIDIQDNFYELGGTSIMGIKIANRINEQYRVTMTIQDVFTHLTVASLGK 1235 A IW + + + I D+F++LGG S+ + + ++++ V + ++ +F H TVA L + Sbjct: 975 AEIWQQVLGISQVGIHDDFFDLGGHSLKAMTVVFQVSKALEVELPVKALFEHPTVAELAR 1034 Query: 1236 LVEQKLGTKTEAGAVNKQEVEYAKTSMPLSHAQRRIWFLQKMNPDLVAYNLPFIRYFDMA 1295 + + KTE A+ Q V A+ P+S AQ+R++ LQ+ + ++YN+ + Sbjct: 1035 FLSR--SEKTEYTAI--QPVA-AQEFYPVSSAQKRMYILQQFEGNGISYNISGAILLEGK 1089 Query: 1296 IDLELLQQAASFLAGRHLLMRTKYVLKDGNPVQEVLPAY-VPAVQSIDAAGQSDPELFVK 1354 +D A LA RH +RT + DG PVQ+V VP Q++ Sbjct: 1090 LDYARFASAVQQLAERHEALRTSFHRIDGEPVQKVHEEVEVPLFMLEAPEDQAE------ 1143 Query: 1355 MNIHQQKMKPFNLEMPP-YRIYLYTISDERACLYINFHHILTDGWSIDIYYRELFSLYQA 1413 I ++ ++PF+L + P R L + +R ++ HHI++DG S I RE LYQ Sbjct: 1144 -KIMREFVRPFDLGVAPLMRTGLLKLGKDRHLFLLDMHHIISDGVSSQILLREFAELYQG 1202 Query: 1414 FLHQQPPRLPEVKEDYFDWILEQKAWEESEAFVEHEQFWLKELAKPLPVLSLPSDHKAPA 1473 QP L Y D+ Q ++EA+ + EQ WL A +P+L+LP+D+ P+ Sbjct: 1203 -ADLQPLSL-----QYKDFAAWQNELFQTEAYKKQEQHWLNTFADEIPLLNLPTDYPRPS 1256 Query: 1474 VQTYRGSFHKFTISGELYRKLKAHLETQQITANNFLLSAYFLLLHNLSQEQDIIIGVPAS 1533 VQ++ G F EL +L+ T LL+AY +LL + ++DII+G P + Sbjct: 1257 VQSFAGDLVLFAAGKELLERLQQVASETGTTLYMILLAAYNVLLSKYTGQEDIIVGTPVA 1316 Query: 1534 GRNEQKWESVAGIFINTLCIRIHFQGITTFMELQDAVKHKVWSAMDKAQYPFDLLVEKVN 1593 GR+ E++ GIF+NTL +R TF + VK +A D YPF+ LVEK+ Sbjct: 1317 GRSHADVENIMGIFVNTLALRNQPASSKTFAQFLQEVKQNALAAYDHQDYPFEELVEKLA 1376 Query: 1594 PDRDLSRNPIYNVLFQFYD-------------KLYLENEGISPFELSCLAQETNQQIEIS 1640 RD+SRNP+++ LF + Y IS F+L+ A E+ I+ Sbjct: 1377 IQRDISRNPLFDTLFSLENANQQSLAIAELTASPYELFNKISKFDLALNASESPADIQFQ 1436 Query: 1641 FEYNSDMYTDSTISRFAGYFLNIIGQVVDKPXXXXXXXXXXXXXXXXXXXSRFQGEQADL 1700 + + ++ T+ R A ++L I+ + ++P + Sbjct: 1437 LTFATKLFKKETVERMARHYLEILRWISEQPTASLADIDMMTEAEKRTLLLNVNDTFVER 1496 Query: 1701 EDGQTIHGRFEAQVQKNPHAIALVYEEQQMTFQEVNGKANQLAWMLTGSGVQRNTPVGIF 1760 +H E Q + P +A+VYEE +T++E+N +ANQLA +L G +T +GI Sbjct: 1497 TAATALHQLVEEQAARTPDEVAVVYEEYALTYRELNARANQLARLLRSHGTGPDTLIGIM 1556 Query: 1761 VDRSFSSVIGILAILKAGGAYVPLDPGYPEDRIAYILAHSGAKWLLTENRYLQSVAAFAH 1820 VDRS V+G+LA+LKAGGAY P+DP YP +RI Y+L+ S A LLT+ R+LQ +AA+ Sbjct: 1557 VDRSPGMVVGMLAVLKAGGAYTPIDPSYPPERIQYMLSDSQAPILLTQ-RHLQELAAYQG 1615 Query: 1821 EEGIQIINLSPVKEQSAVSQMYLADYEDELSRENPRTGGHGPDRMYIMYTSGSTGKPKGV 1880 E II++ ++ A+ + ++ ++ D Y++YTSGSTG PKGV Sbjct: 1616 E----IIDV----DEEAIYTGADTNLDNVAGKD---------DLAYVIYTSGSTGNPKGV 1658 Query: 1881 LVTHSNVLNFVTWSIGELQLQPKDALLLVTSISFDISVFEIFAALLSGSRLCIASMEHLK 1940 +++H + N + W L +DA+L T SFD SV+E + L++G +L +A + + Sbjct: 1659 MISHQAICNHMLWMRETFPLTTEDAVLQKTPFSFDASVWEFYLPLITGGQLVLAKPDGHR 1718 Query: 1941 DTECLLAYMEAQHITIWHSVPSLMVQLMTLLRHHPGRYRHSPVLQQLRHLMLGGEAWSTS 2000 D + + + IT VPSL+ +MT PG L+ + GGEA + + Sbjct: 1719 DIAYMTRLIRDEKITTLQMVPSLLDLVMT----DPGW----SACTSLQRVFCGGEALTPA 1770 Query: 2001 LAASLRETFPQAEIRNMYGPTEATIWVSSYKPGPEIDESHPVMLIGRPIANNRLIILDQY 2060 L + ET QA++ N+YGPTE TI ++Y P P E + + IG+PI N RL +++ Sbjct: 1771 LVSRFYET-QQAQLINLYGPTETTI-DATYWPCPRQQE-YSAIPIGKPIDNVRLYVVNAS 1827 Query: 2061 GNVCPPGVAGEIYIAGNNVTQGYYNDEEKTRMAFI--PQSNGQIFYKTGDSGRYLPEGNV 2118 + P GVAGE+ IAG+ + +GY+ EE T+ +F+ P G Y+TGD RYLP+G++ Sbjct: 1828 NQLQPVGVAGELCIAGDGLARGYWQREELTKASFVDNPFEPGGTMYRTGDMVRYLPDGHI 1887 Query: 2119 EFTGRRDQLVKVRGYRIELGEIEQALKELTSLQQIAVTAVKDGETSKIVCLY-TGDQPVP 2177 E+ GR D VK+RG+RIELGEIE L + +++ + V A +DG+ + Y +Q + Sbjct: 1888 EYLGRIDHQVKIRGHRIELGEIEATLLQHEAVKAVVVMARQDGKGQNSLYAYVVAEQDIQ 1947 Query: 2178 QNQLKDAVRKRLPEYMIPAQFFHVERFLLTPNGKMDWRSMEKFVRETPGSIEAAGIRNEV 2237 +L+ + LP YM+P+ F +E+ L+ NGK+D +++ + + RNE Sbjct: 1948 TAELRTYLSATLPAYMVPSAFVFLEQLPLSANGKVDRKALPQPEDAAASAAVYVAPRNEW 2007 Query: 2238 DKKLSEIWKKLLGIPAVGIQENFFDIGGNSLLVVQMQGMIQQEFFQDIPMMDLFKYTSIE 2297 + KL+ IW+ +LG+ +G+ ++FF++GG+SL + + ++Q+ F D+P+ LF+ +I Sbjct: 2008 EAKLAAIWESVLGVEPIGVHDHFFELGGHSLKAMHVISLLQRSFQVDVPLKVLFESPTIA 2067 Query: 2298 KIS 2300 ++ Sbjct: 2068 GLA 2070 Score = 592 bits (1525), Expect = e-166, Method: Compositional matrix adjust. Identities = 363/1152 (31%), Positives = 590/1152 (51%), Gaps = 63/1152 (5%) Query: 1172 EQQIARIWGNLFQMPNIDIQDNFYELGGTSIMGIKIANRINEQYRVTMTIQDVFTHLTVA 1231 E ++A++W + +P + D+F+ LGG S+ +++ + ++ +Y+V + ++ +F T+ Sbjct: 5125 EARLAQVWEQVLNVPQVGALDDFFALGGHSLRAMRVLSSMHNEYQVDIPLRILFEKPTIQ 5184 Query: 1232 SLGKLVEQKLGTKTEAGAVNKQEVEYAKTSMPLSHAQRRIWFLQKMNPDLVAYNLPFIRY 1291 L +E+ T G V E + P+S AQ+R++ L + ++YN+P Sbjct: 5185 ELAAFIEE-----TAKGNVFSIEPVQKQAYYPVSSAQKRMYILDQFEGVGISYNMPSTML 5239 Query: 1292 FDMAIDLELLQQAASFLAGRHLLMRTKYVLKDGNPVQEVLPAYVPAVQSIDAAGQSDPEL 1351 + ++ ++ A L RH +RT + + +G PVQ + A+ + Q EL Sbjct: 5240 IEGKLERTRVEAAFQRLIARHESLRTSFAVVNGEPVQNIHEDVPFALAYSEVTEQEAREL 5299 Query: 1352 FVKMNIHQQKMKPFNLEMPPY-RIYLYTISDERACLYINFHHILTDGWSIDIYYRELFSL 1410 + ++PF+LE+ P R+ L I ++R L+ + HH ++DG S I E L Sbjct: 5300 VSSL------VQPFDLEVAPLIRVSLLKIGEDRYVLFTDMHHSISDGVSSGILLAEWVQL 5353 Query: 1411 YQAFLHQQPPRLPEVKEDYFDWILEQKAWEESEAFVEHEQFWLKELAKPLPVLSLPSDHK 1470 YQ + LPE++ Y D+ + Q+ + +S AF + E +WL+ A +PVL+LP+D Sbjct: 5354 YQGDV------LPELRIQYKDFAVWQQEFSQSAAFHKQEAYWLQTFADDIPVLNLPTDFT 5407 Query: 1471 APAVQTYRGSFHKFTISGELYRKLKAHLETQQITANNFLLSAYFLLLHNLSQEQDIIIGV 1530 P+ Q++ G L L + T LL+AY +LL + ++DII+G Sbjct: 5408 RPSTQSFAGDQCTIGAGKALTEGLHQLAQATGTTLYMVLLAAYNVLLAKYAGQEDIIVGT 5467 Query: 1531 PASGRNEQKWESVAGIFINTLCIRIHFQGITTFMELQDAVKHKVWSAMDKAQYPFDLLVE 1590 P +GR+ E + G+F+NTL +R Q TF E VK A YPF+ LVE Sbjct: 5468 PITGRSHADLEPIVGMFVNTLAMRNKPQREKTFSEFLQEVKQNALDAYGHQDYPFEELVE 5527 Query: 1591 KVNPDRDLSRNPIYNVLFQFYDK----LYLENEGISPF-----------ELSCLAQETNQ 1635 K+ RDLSRNP+++ +F F + + L ++PF +L+ A E + Sbjct: 5528 KLAIARDLSRNPLFDTVFTFQNSTEEVMTLPECTLAPFMTDETGQHAKFDLTFSATEERE 5587 Query: 1636 QIEISFEYNSDMYTDSTISRFAGYFLNIIGQVVDKPXXXXXXXXXXXXXXXXXXXSRFQG 1695 ++ I EY++ ++T T+ RF+ +FL I +V P + F Sbjct: 5588 EMTIGVEYSTSLFTRETMERFSRHFLTIAASIVQNPHIRLGEIDMLLPEEKQQILAGFND 5647 Query: 1696 EQADLEDGQTIHGRFEAQVQKNPHAIALVYEEQQMTFQEVNGKANQLAWMLTGSGVQRNT 1755 +T+H FE QV K P AL++ EQ +T+ E+N +AN+LA +L GV + Sbjct: 5648 TAVSYALDKTLHQLFEEQVDKTPDQAALLFSEQSLTYSELNERANRLARVLRAKGVGPDR 5707 Query: 1756 PVGIFVDRSFSSVIGILAILKAGGAYVPLDPGYPEDRIAYILAHSGAKWLLTENRYLQSV 1815 V I +RS VIGIL ILKAGGAYVP+DPGYP++RI Y+L S A LL++ L + Sbjct: 5708 LVAIMAERSPEMVIGILGILKAGGAYVPVDPGYPQERIQYLLEDSNAALLLSQAHLLPLL 5767 Query: 1816 AAFAHEEGIQIINLSPVKEQSAVSQMYLADYEDELSRENPRTGGHGPDRMYIMYTSGSTG 1875 A + E + ++L+ A+ + LS N D Y++YTSG+TG Sbjct: 5768 AQVSSELP-ECLDLN-------------AELDAGLSGSNLPAVNQPTDLAYVIYTSGTTG 5813 Query: 1876 KPKGVLVTHSNVLNFVTWSIGELQLQPKDALLLVTSISFDISVFEIFAALLSGSRLCIAS 1935 KPKGV++ H ++N + W E P D L V S +FD V +FA LL G+ + Sbjct: 5814 KPKGVMIPHQGIVNCLQWRRDEYGFGPSDKALQVFSFAFDGFVASLFAPLLGGATCVLPQ 5873 Query: 1936 MEHLKDTECLLAYMEAQHITIWHSVPSLMVQLMTLLRHHPGRYRHSPVLQQLRHLMLGGE 1995 KD L M A +T ++ VPSL ++ + QLR + LGGE Sbjct: 5874 EAAAKDPVALKKLMAATEVTHYYGVPSLFQAILDC--------STTTDFNQLRCVTLGGE 5925 Query: 1996 AWSTSLAASLRETFPQAEIRNMYGPTEATIWVSSYKPGPEIDESHPVMLIGRPIANNRLI 2055 L +E P EI N YGPTE ++ + + E+ + IGRP+AN ++ Sbjct: 5926 KLPVQLVQKTKEKHPAIEINNEYGPTENSVVTTISRS----IEAGQAITIGRPLANVQVY 5981 Query: 2056 ILDQYGNVCPPGVAGEIYIAGNNVTQGYYNDEEKTRMAFI--PQSNGQIFYKTGDSGRYL 2113 I+D+ ++ P GV GE+ I G + +GY N E T F+ P G+ YKTGD ++ Sbjct: 5982 IVDEQHHLQPIGVVGELCIGGAGLARGYLNKPELTAEKFVANPFRPGERMYKTGDLVKWR 6041 Query: 2114 PEGNVEFTGRRDQLVKVRGYRIELGEIEQALKELTSLQQIAVTAVKDGET--SKIVCLYT 2171 +G +E+ GR D+ VKVRGYRIE+GEIE A+ + Q V A D T S + + Sbjct: 6042 TDGTIEYIGRADEQVKVRGYRIEIGEIESAVLAYQGIDQAVVVARDDDATAGSYLCAYFV 6101 Query: 2172 GDQPVPQNQLKDAVRKRLPEYMIPAQFFHVERFLLTPNGKMDWRSMEKFVRETPGSIEAA 2231 V + L+ + K LP YMIP+ F +++ L+ NGK+D +++ K + + E Sbjct: 6102 AATAVSVSGLRSHLAKELPAYMIPSYFVELDQLPLSANGKVDRKALPKPQQSDATTREYV 6161 Query: 2232 GIRNEVDKKLSEIWKKLLGIPAVGIQENFFDIGGNSLLVVQMQGMIQQEFFQDIPMMDLF 2291 RN +++L+ IW+++LG+ +GI + FF++GG+SL + + + ++P+ +F Sbjct: 6162 APRNATEQQLAAIWQEVLGVEPIGITDQFFELGGHSLKATLLIAKVYEYMQIELPLNLIF 6221 Query: 2292 KYTSIEKISDYL 2303 +Y +IEK++D++ Sbjct: 6222 QYPTIEKVADFI 6233 Score = 567 bits (1460), Expect = e-159, Method: Compositional matrix adjust. Identities = 369/1197 (30%), Positives = 607/1197 (50%), Gaps = 67/1197 (5%) Query: 1146 REQIKHPEAEIDVRLTGRA-DQSYTEIEQQIARIWGNLFQMPNIDIQDNFYELGGTSIMG 1204 R + P E R TG A + + E ++ +IW + +P I I DNF+E+GG S+ Sbjct: 4057 RRALPQPSGE---RTTGSAFVAAQNDTEAKLQQIWQEVLGIPAIGIHDNFFEIGGHSLKA 4113 Query: 1205 IKIANRINEQYRVTMTIQDVFTHLTVASLGKLVEQKLGTKTEAGAVNKQEVEYAKTSMPL 1264 + + ++++ ++V + ++ +F T+ L + + + E Q VE A P+ Sbjct: 4114 MNVITQVHKTFQVELPLKALFATPTIHELAAHIAESAFEQFE----TIQPVEPA-AFYPV 4168 Query: 1265 SHAQRRIWFLQKMNPDLVAYNLPFIRYFDMAIDLELLQQAASFLAGRHLLMRTKYVLKDG 1324 S AQ+R++ L + ++YN+P + + +D + A L RH +RT + +G Sbjct: 4169 SFAQKRMYILHQFEGSGISYNVPSVLVLEGKLDYDRFAAAIQSLVKRHESLRTSFHSVNG 4228 Query: 1325 NPVQEVLPAYVPAVQSIDAAGQSDPELFVKMNIHQQKMKPFNLEMPP-YRIYLYTISDER 1383 P+Q V P V+ ++A L Q+ ++PF+LE+ P +R+ L + ER Sbjct: 4229 EPLQRVHPDVELPVRLLEATEDQSESLI------QELIQPFDLEIAPLFRVNLIKLGAER 4282 Query: 1384 ACLYINFHHILTDGWSIDIYYRELFSLYQAFLHQQPPRLPEVKEDYFDWILEQKAWEESE 1443 +++ HHI++DG S+ + E+ SLY +L +++ Y D+ + Q +S+ Sbjct: 4283 HLFFMDMHHIISDGVSLAVIVEEIASLYAG------KQLSDLRIQYKDFAVWQTKLAQSD 4336 Query: 1444 AFVEHEQFWLKELAKPLPVLSLPSDHKAPAVQTYRGSFHKFTISGELYRKLKAHLETQQI 1503 F + E FW + A +P+L+LP D+ P+VQ++ G L +L+ Sbjct: 4337 RFQKQEDFWTRTFAGEIPLLNLPHDYPRPSVQSFDGDTVALGTGHHLLEQLRKLAAETGT 4396 Query: 1504 TANNFLLSAYFLLLHNLSQEQDIIIGVPASGRNEQKWESVAGIFINTLCIRIHFQGITTF 1563 T LL+AY +LL + +++I++G P +GR+ E + G+F+NTL ++ G +F Sbjct: 4397 TLFMVLLAAYHVLLSKYAGQEEIVVGTPIAGRSHADVERIVGMFVNTLALKNTAAGSLSF 4456 Query: 1564 MELQDAVKHKVWSAMDKAQYPFDLLVEKVNPDRDLSRNPIYNVLFQ-------------F 1610 + VK A + YPF+ LVEK+ RDLSRNP+++ +F Sbjct: 4457 RAFLEDVKQNALHAFEHQDYPFEHLVEKLQVRRDLSRNPLFDTMFSLGLAESAEGEVADL 4516 Query: 1611 YDKLYLENEGISPFELSCLAQETNQQIEISFEYNSDMYTDSTISRFAGYFLNIIGQVVDK 1670 Y N I+ F+LS A E + + F Y + ++ T+ R A +++ ++ + Sbjct: 4517 KVSPYPVNGHIAKFDLSLDAMEKQDGLLVQFSYCTKLFAKETVDRLAAHYVQLLQTITAD 4576 Query: 1671 PXXXXXXXXXXXXXXXXXXXSRFQGEQADLEDGQTIHGRFEAQVQKNPHAIALVYEEQQM 1730 P F + +T FE QV+K P+ IA+++ +Q+ Sbjct: 4577 PDIELARISVLSKAETEHMLHSFLATKTAYPTDKTFQKLFEEQVEKTPNEIAVLFGNEQL 4636 Query: 1731 TFQEVNGKANQLAWMLTGSGVQRNTPVGIFVDRSFSSVIGILAILKAGGAYVPLDPGYPE 1790 T+QE+N KANQLA +L GV+ + VGI VDRS VIG+LA+LKAGG +VP+DP YP Sbjct: 4637 TYQELNAKANQLARVLRRKGVKPESTVGILVDRSLYMVIGMLAVLKAGGTFVPIDPDYPL 4696 Query: 1791 DRIAYILAHSGAKWLLTENRYLQSVAAFAHEEGIQIINLSPVKEQSAVSQMYLADYEDEL 1850 +R A++L S AK LLT + + S AF +E + + V Q + E Sbjct: 4697 ERQAFMLEDSEAKLLLTLQK-MNSQVAFPYE--------TFYLDTETVDQEETGNLEHVA 4747 Query: 1851 SRENPRTGGHGPDRMYIMYTSGSTGKPKGVLVTHSNVLNFVTWSIGELQLQPKDALLL-V 1909 EN YI+YTSG+TGKPKGV++ H + N E L LL + Sbjct: 4748 QPEN---------VAYIIYTSGTTGKPKGVVIEHRSYANVAFAWKDEYHLDSFPVRLLQM 4798 Query: 1910 TSISFDISVFEIFAALLSGSRLCIASMEHLKDTECLLAYMEAQHITIWHSVPSLMVQLMT 1969 S +FD+S + ALL+G +L I D L + ITI+ + P+L++ LM Sbjct: 4799 ASFAFDVSTGDFARALLTGGQLVICPNGVKMDPASLYETIRRHEITIFEATPALIMPLMH 4858 Query: 1970 LLRHHPGRYRHSPVLQQLRHLMLGGEAWSTSLAASLRETFPQA-EIRNMYGPTEATIWVS 2028 + Y + + Q++ L+LG ++ +L F Q I N YG TEA I S Sbjct: 4859 YV------YENELDMSQMKLLILGADSCPAEDFKTLLARFGQKMRIINSYGVTEACIDTS 4912 Query: 2029 SYKPGPEIDESHPVMLIGRPIANNRLIILDQYGNVCPPGVAGEIYIAGNNVTQGYYNDEE 2088 Y+ + IG+P+ N + ++D + N+ P GV GE+ I G V +GY N E Sbjct: 4913 YYEETDVTAIRSGTVPIGKPLPNMTMYVVDAHLNLQPVGVVGELCIGGAGVARGYLNRPE 4972 Query: 2089 KTRMAFIPQ--SNGQIFYKTGDSGRYLPEGNVEFTGRRDQLVKVRGYRIELGEIEQALKE 2146 T F+P + G+ Y+TGD ++ +GNVEF GR D VK+RG RIELGEIE L++ Sbjct: 4973 LTEEKFVPNPFAPGERLYRTGDLAKWRADGNVEFLGRNDHQVKIRGVRIELGEIETQLRK 5032 Query: 2147 LTSLQQIAVTAVKDGETSKIVCLY-TGDQPVPQNQLKDAVRKRLPEYMIPAQFFHVERFL 2205 L + + V A +D K +C Y D + +L+ + K LP+ MIPA F ++ Sbjct: 5033 LDGITEAVVVAREDRGQEKELCAYVVADHKLDTAELRANLLKELPQAMIPAYFVTLDALP 5092 Query: 2206 LTPNGKMDWRSMEKFVRETPGSIEAAGIRNEVDKKLSEIWKKLLGIPAVGIQENFFDIGG 2265 LT NGK+D RS+ + E R+ + +L+++W+++L +P VG ++FF +GG Sbjct: 5093 LTANGKVDRRSLPAPDVTMLRTTEYVAPRSVWEARLAQVWEQVLNVPQVGALDDFFALGG 5152 Query: 2266 NSLLVVQMQGMIQQEFFQDIPMMDLFKYTSIEKISDYLQEHTVK--VSSVETGQKRA 2320 +SL +++ + E+ DIP+ LF+ +I++++ +++E T K V S+E QK+A Sbjct: 5153 HSLRAMRVLSSMHNEYQVDIPLRILFEKPTIQELAAFIEE-TAKGNVFSIEPVQKQA 5208 Score = 374 bits (960), Expect = e-101, Method: Compositional matrix adjust. Identities = 297/1073 (27%), Positives = 505/1073 (47%), Gaps = 80/1073 (7%) Query: 1263 PLSHAQRRIWFLQKMNPDLVAYNLPFIRYFDMAIDLELLQQAASFLAGRHLLMRTKYVLK 1322 PL+ Q + F + AY L + L L +++ + L + ++RT +V + Sbjct: 12 PLTPLQEGMLFHAVTDTGSSAYCLQMSATIEGDFHLPLFEKSLNKLVENYEVLRTAFVYQ 71 Query: 1323 D-GNPVQEVLPAYVPAVQSIDAAGQSDPELFVKMNIHQQKMKPFNLEMPP-YRIYLYTIS 1380 + P Q V V + A E + + ++ F+L + ++ + Sbjct: 72 NMQRPRQVVFKERKVTVPCENIAHLPSAEQDAYIQAYTKQHHAFDLTKDNLMKAAIFQTA 131 Query: 1381 DERACLYINFHHILTDGWSIDIYYRELFSLYQAFLHQQP-PRLPEVKEDYFDWILEQKAW 1439 + + L FHHI+ DGW++ + +L + Y A +P PR E + Y ++I W Sbjct: 132 ENKYRLVWAFHHIIVDGWTLGVLLHKLLTYYAALRKGEPIPR--EATKPYSEYI----KW 185 Query: 1440 EESEAFVEHEQFWLKELAKPLPVLSLPSDHKAPAVQTYRGSFHKFTISGELYRKLKAHLE 1499 + + E +W LA + P Y FTI+ E ++L Sbjct: 186 LDKQNKDEALAYWQNYLAGYDHQAAFPKKKLGTEASRYEHVEAMFTIAPEKTQQLIQIAN 245 Query: 1500 TQQITANNFLLSAYFLLLHNLSQEQDIIIGVPASGR--NEQKWESVAGIFINTLCIRIHF 1557 Q T ++ + + +L D++ G SGR Q ES+ G+FINT+ R+ Sbjct: 246 QNQATMSSVFQALWGILASTYKNADDVVFGSVVSGRPPQIQGIESMVGLFINTIPTRVQT 305 Query: 1558 QGITTFMELQDAVKHKVWSAMDKAQYPFDLLVEKVNPDRDLSRNPI-YNVLFQFYD---- 1612 TF EL V+ + A+ A Y F L E + L + I + V F+ Y Sbjct: 306 NKQQTFSELLQTVQKQ---ALASATYDFAPLYE-IQSTTVLKQELIDHLVTFENYPDHSM 361 Query: 1613 KLYLENEGI----------SPFELSCL-AQETNQQIEISFEYNSDMYTDSTISRFAGYFL 1661 K E+ G + ++L+ + A + ++ + YN+ +Y S ++R G+ Sbjct: 362 KHLEESLGFQFTVESGDEQTSYDLNVVVALAPSNELYVKLSYNAAVYESSFVNRIEGHLR 421 Query: 1662 NIIGQVVDKPXXXXXXXXXXXXXXXXXXXSRFQGEQADLEDGQTIHGRFEAQVQKNPHAI 1721 +I QV+ P + A+ +TI Q + P Sbjct: 422 TVIDQVIGNPHVHLHEIGIITEEEKQQLLVAYNDTAAEYPRDKTIFELIAEQASRTPAKA 481 Query: 1722 ALVYEEQQMTFQEVNGKANQLAWMLTGSGVQRNTPVGIFVDRSFSSVIGILAILKAGGAY 1781 A+V E +T+QE+ ++ QLA L G+ + V I + S ++ I+A+L++G AY Sbjct: 482 AVVCGEDTLTYQELMERSAQLANALREKGIASGSIVSIMAEHSLELIVAIMAVLRSGAAY 541 Query: 1782 VPLDPGYPEDRIAYILAHSGAKWLLTENRYLQSVAAFAHEEGIQIINLSPVKEQSAVSQM 1841 +P+DP YP+DRI Y+L S LLT++ +LQ FA S + Sbjct: 542 LPIDPEYPQDRIQYLLDDSQTTLLLTQS-HLQPNIRFAG------------------SVL 582 Query: 1842 YLAD---YEDELSRENPRTGGHGPDRM-YIMYTSGSTGKPKGVLVTHSNVLNFVTWSIGE 1897 YL D YE + P + PD + Y++YTSGSTG PKG ++TH ++N++ W+ + Sbjct: 583 YLDDRSLYEGGSTSFAPESK---PDDLAYMIYTSGSTGNPKGAMITHQGLVNYIWWA-NK 638 Query: 1898 LQLQPKDA-LLLVTSISFDISVFEIFAALLSGSRLCIASMEHLKDTECLLAYMEAQHITI 1956 + +Q + L +SISFD++V IF LLSG+ + + + +L ++ + I Sbjct: 639 VYVQGEAVDFPLYSSISFDLTVTSIFTPLLSGNTIHV--YRGADKVQVILDIIKDNKVGI 696 Query: 1957 WHSVPSLMVQLMTLLRHHPGRYRHSPVLQQLRHLMLGGEAWSTSLAASLRETFPQ-AEIR 2015 P+ + L+ H G+ +R ++GGE T LA + + F + +I Sbjct: 697 IKLTPTHL----KLIEHIDGK------ASSIRRFIVGGENLPTKLAKQIYDHFGENVQIF 746 Query: 2016 NMYGPTEATI--WVSSYKPGPEIDESHPVMLIGRPIANNRLIILDQYGNVCPPGVAGEIY 2073 N YGPTE + + Y P ES P IG P N +L +LD P G GE+Y Sbjct: 747 NEYGPTETVVGCMIYLYDPQTTTQESVP---IGVPADNVQLYLLDASMQPVPVGSLGEMY 803 Query: 2074 IAGNNVTQGYYNDEEKTRMAFI--PQSNGQIFYKTGDSGRYLPEGNVEFTGRRDQLVKVR 2131 IAG+ V +GY+N E T+ FI P G Y+TGD ++LP+GN+E+ GR D VK+R Sbjct: 804 IAGDGVAKGYFNRPELTKEKFIDNPFRPGTKMYRTGDLAKWLPDGNMEYAGRMDYQVKIR 863 Query: 2132 GYRIELGEIEQALKELTSLQQIAVTAVKDGETSKIVCLY-TGDQPVPQNQLKDAVRKRLP 2190 G+RIE+GEIE L + ++++ V KD ++ Y ++ + +L++ + + LP Sbjct: 864 GHRIEMGEIETRLTQHEAVKEAVVIVEKDESGQNVLYAYLVSERELTVAELREFLGRTLP 923 Query: 2191 EYMIPAQFFHVERFLLTPNGKMDWRSMEKFVRETPGSIEAAGIRNEVDKKLSEIWKKLLG 2250 YMIP+ F + LT NGK++ + + K A +NE++ KL+EIW+++LG Sbjct: 924 SYMIPSFFIRLAEIPLTANGKVERKKLPKPAGAVVTGTAYAAPQNEIEAKLAEIWQQVLG 983 Query: 2251 IPAVGIQENFFDIGGNSLLVVQMQGMIQQEFFQDIPMMDLFKYTSIEKISDYL 2303 I VGI ++FFD+GG+SL + + + + ++P+ LF++ ++ +++ +L Sbjct: 984 ISQVGIHDDFFDLGGHSLKAMTVVFQVSKALEVELPVKALFEHPTVAELARFL 1036 >B2IXJ9.1 B2IXJ9_NOSP7 Amino acid adenylation domain protein EC=5.1.1.11 EC=6.2.1.26 Length = 3242 Score = 638 bits (1645), Expect = e-180, Method: Compositional matrix adjust. Identities = 403/1265 (31%), Positives = 661/1265 (52%), Gaps = 81/1265 (6%) Query: 1102 PRHALHAFDQILGKKINNIVVGSIQFNNDLFWNRPLPVSLAPAI-REQIKHPEA--EIDV 1158 P ++ Q LG K+ ++ S + LP++ + R + PE E++V Sbjct: 2005 PTPTINELRQFLGSKLPEYMIPSA-----FVFLETLPLTPNGKVDRRALPLPETLRELEV 2059 Query: 1159 RLTGRADQSYTEIEQQIARIWGNLFQMPNIDIQDNFYELGGTSIMGIKIANRINEQYRVT 1218 T IE+ +A IW ++ ++ I + DNF+ELGG S++ ++ +RI +++ Sbjct: 2060 NFVA----PRTPIEEILAPIWADVLRVEQIGVYDNFFELGGHSLLATQLVSRIRTTFKIE 2115 Query: 1219 MTIQDVFTHLTVASLGKLVEQKLGTKTEAGAVNKQEVEYAKTSMPLSHAQRRIWFLQKMN 1278 + ++ +F T+A+L + ++Q +E Q V + ++PLS AQ+R+WFL +++ Sbjct: 2116 LPLRSLFEAATIANLAEYIQQYQRNSSELLIPPLQPVARNE-NIPLSFAQQRLWFLNQLD 2174 Query: 1279 PDLVAYNLPFIRYFDMAIDLELLQQAASFLAGRHLLMRTKYVLKDGNPVQEVLPAYVPAV 1338 P+ AYN+P F +++ L+Q+ S + RH +RT ++ + G VQ + P + Sbjct: 2175 PNSAAYNIPGAVSFQGQLNVAALEQSLSEIIRRHEALRTNFITQAGEAVQIIRPVSSWTM 2234 Query: 1339 QSIDAAGQSDPELFVKMNIHQ----QKMKPFNL-EMPPYRIYLYTISDERACLYINFHHI 1393 ID Q P ++ I Q +PF+L R L IS+ L HHI Sbjct: 2235 TVIDL--QDLPADEREIEIQQLATVAAQQPFDLVNESLIRTTLLAISETENILLFCMHHI 2292 Query: 1394 LTDGWSIDIYYRELFSLYQAFLHQQPPRLPEVKEDYFDWILEQKAWEESEAFVEHEQFWL 1453 ++DGWS+ ++ +E+ LY AF LPE+ Y D+ + Q+ W + E +W Sbjct: 2293 VSDGWSMGVFVQEVAELYTAFSQGHLSSLPELAIQYADFAVWQRQWLQGEVKESQINYWR 2352 Query: 1454 KELAKPLPVLSLPSDHKAPAVQTYRGSFHKFTISGELYRKLKAHLETQQITANNFLLSAY 1513 ++LA +L LP+D PAVQT+RG+ F++S EL + L + +T LL+A+ Sbjct: 2353 EQLAGAPALLELPTDRPRPAVQTFRGTTQSFSLSEELSQALSLLSRQEGVTLFMTLLAAF 2412 Query: 1514 FLLLHNLSQEQDIIIGVPASGRNEQKWESVAGIFINTLCIRIHFQGITTFMELQDAVKHK 1573 LLH + + DI++G + RN + E + G F+NTL R G +F +L + V+ Sbjct: 2413 DTLLHRYTGQTDILVGSAIANRNYSEIEGLIGFFVNTLVFRTDVSGNPSFRQLLERVREV 2472 Query: 1574 VWSAMDKAQYPFDLLVEKVNPDRDLSRNPIYNVLFQFYDK------------LYLENEGI 1621 A PF+LLVE + P+RDLS P++ V+F F + L E + Sbjct: 2473 SLEAHTHQDLPFELLVEALQPERDLSHTPLFQVMFVFQNTPTSDIELPGLTLSSLTTESL 2532 Query: 1622 SP-FELSCLAQETNQQIEISFEYNSDMYTDSTISRFAGYFLNIIGQVVDKPXXXXXXXXX 1680 + F+L+ + T+Q + ++EYN+D++ TI+R G+F ++ +V P Sbjct: 2533 TAKFDLTLAFENTDQGLVGAWEYNTDLFDTLTIARMIGHFQTLLESIVTNPEQPVSQLPL 2592 Query: 1681 XXXXXXXXXXSRFQGEQADLEDGQTIHGRFEAQVQKNPHAIALVYEEQQMTFQEVNGKAN 1740 + + Q + Q IH F AQ ++NP +A V+ QQ+T+QE+N +AN Sbjct: 2593 LTVNEQHQLLNEWNNTQTEYPQNQCIHELFTAQAERNPDLVAAVFGSQQITYQELNSRAN 2652 Query: 1741 QLAWMLTGSGVQRNTPVGIFVDRSFSSVIGILAILKAGGAYVPLDPGYPEDRIAYILAHS 1800 QLA L GV VGIFV+RS ++G+L ILKAGGAYVPLDP YP++R++ +LA S Sbjct: 2653 QLAHYLRTLGVGTEVLVGIFVERSLEMLVGLLGILKAGGAYVPLDPDYPQERLSLMLADS 2712 Query: 1801 GAKWLLTENRYLQSVAAFAH-----EEGIQIINLSPVKEQSAVSQMYLADYEDELSRENP 1855 LLT+ R ++ + + + G IIN + + + ++ D+L+ Sbjct: 2713 QVPVLLTQQRLVEKLPEYGQPVVCLDTGWDIIN------RESTANLHSEVTADKLA---- 2762 Query: 1856 RTGGHGPDRMYIMYTSGSTGKPKGVLVTHSNVLNFVTWSIGELQLQPKDALLLVTSISFD 1915 Y++YTSGSTGKPKGV V H V N + ++ +QL D + + SFD Sbjct: 2763 ----------YVIYTSGSTGKPKGVAVPHRAV-NRLVFNTNYIQLDANDCIAQAANASFD 2811 Query: 1916 ISVFEIFAALLSGSRLCIASMEHLKDTECLLAYMEAQHITIWHSVPSLMVQLMTLLRHHP 1975 + FEI+ ALL G+RL + + AY+ Q I++ +L QL + + Sbjct: 2812 AATFEIWGALLHGARLVGVTHNIALSPQEFAAYIREQEISVLFLTTALFNQLASFVPQ-- 2869 Query: 1976 GRYRHSPVLQQLRHLMLGGEAWSTSLAASLRETFPQAEIRNMYGPTEATIWVSSYKPGPE 2035 LR+L+ GGEA + + + ++YGPTE+T + SS+ + Sbjct: 2870 -------AFNTLRYLLFGGEAVDPRWVKEVLQNGAPQHLLHVYGPTESTTF-SSWFLIED 2921 Query: 2036 IDESHPVMLIGRPIANNRLIILDQYGNVCPPGVAGEIYIAGNNVTQGYYNDEEKTRMAFI 2095 + + + IG+PI+N ++ +LDQ P GV GE+YI G+ + QGY N E T+ FI Sbjct: 2922 VPATATTIPIGQPISNTQIYLLDQNLQPVPIGVPGELYIGGDGLAQGYLNRLELTQEKFI 2981 Query: 2096 PQS-NGQIFYKTGDSGRYLPEGNVEFTGRRDQLVKVRGYRIELGEIEQALKELTSLQQIA 2154 N YKTGD GRYLP+GN+E+ R D VK+RG+RIELGEIE AL + +++++ Sbjct: 2982 ANPFNNSKLYKTGDLGRYLPDGNIEYLARIDNQVKIRGFRIELGEIETALLQHPAIREVV 3041 Query: 2155 VTAVKD--GETSKIVC--------LYTGDQPVPQNQLKDAVRKRLPEYMIPAQFFHVERF 2204 V A +D + +C ++ +Q + L+ ++++LP YMIPA F +E+F Sbjct: 3042 VLAREDISDDACGGLCQRRLVAYIIFELNQTHSISDLRSFLQRQLPNYMIPAAFVFLEQF 3101 Query: 2205 LLTPNGKMDWRSMEKFVRETPGSIEAAGIRNEVDKKLSEIWKKLLGIPAVGIQENFFDIG 2264 LTPNGK+D RS+ + R+++++ ++ IW+++L + VGI +NFFD+G Sbjct: 3102 PLTPNGKIDRRSLPAPDLSAQFAASYVAPRSKIEQAIANIWQEVLQLEKVGIDDNFFDLG 3161 Query: 2265 GNSLLVVQMQGMIQQEFFQDIPMMDLFKYTSIEKISDYL-QEHTVKVSSVETGQKRADMR 2323 G+SLL+V++ +Q+ QDI ++++FKY +I ++ YL E T S +E + Sbjct: 3162 GHSLLMVKLTQKLQEFLNQDISLLEMFKYPTISTLAKYLSSEKTDSASDIEKKNNQITDI 3221 Query: 2324 KRLRN 2328 K RN Sbjct: 3222 KAGRN 3226 Score = 480 bits (1235), Expect = e-133, Method: Compositional matrix adjust. Identities = 357/1190 (30%), Positives = 589/1190 (49%), Gaps = 103/1190 (8%) Query: 1169 TEIEQQIARIWGNLFQMPNIDIQDNFYELGGTSIMGIKIANRINEQYRVTMTIQDVFTHL 1228 T E+ + IW + + + I DNF+ LGG SI I++ ++ +Q ++ ++Q +F H Sbjct: 999 TPTEKLLTDIWAQVLGLEQVGINDNFFALGGDSIRSIQVQSQSQKQ-GLSFSLQQLFVHQ 1057 Query: 1229 TVASL---------GKLVEQKLGTKTEAGAVNKQEV-EYAKTSMPLSHAQRRIWFLQKMN 1278 T+++L +++ + + ++Q++ + + + PL+ Q + F ++N Sbjct: 1058 TISNLVQELQSVEVSRVIIESEKPFSLISETDRQKLPDEVEDAYPLTMLQMGMLFHSELN 1117 Query: 1279 PDLVAYNLPFIRYFDMAIDLELLQQAASFLAGRHLLMRTKYVLKD-GNPVQEVLPAYVPA 1337 D Y+ + +LE Q A L RH ++RT L + P+Q V Sbjct: 1118 EDTAVYHNVSSFHLQAHFNLEKFQTAVEQLVARHPILRTSIDLSNFSEPLQLVHRQVPIP 1177 Query: 1338 VQSIDAAGQSDPELFVKMN--IHQQKMKPFNLEMPPY-RIYLYTISDERACLYINFHHIL 1394 +Q D + S E K++ +K + F+ + P R ++ S E HH + Sbjct: 1178 LQMKDLSHLSVDEQQQKIDAWFEAEKNRKFDWKQSPLLRFQIHCYSPEEFQFSFTEHHAI 1237 Query: 1395 TDGWSIDIYYRELFSLYQAFLHQQP-PRLPEVKEDYFDWI-LEQKAWEESEAFVEHEQFW 1452 DGWS+ ELF Y + ++Q+ P LP + +++ LE++A E HE +W Sbjct: 1238 LDGWSVASMLNELFGNYFSLVNQKAQPLLPSPSSSFRNFVALERQALGSKE----HEYYW 1293 Query: 1453 LKELAKPLPVLSLP----SDHKAPAVQTYRGSFHKFTISGELYRKLKAHLETQQITANNF 1508 ++L K + +P S KA Q +S +LY L+ + + + Sbjct: 1294 TEKL-KECTITMVPRWYSSQQKAKVRQV---GTQDVPLSADLYNGLQKLAQFIGVPLKSV 1349 Query: 1509 LLSAYFLLLHNLSQEQDIIIGVPASGRNEQK-WESVAGIFINTLCIRIHFQGITTFMELQ 1567 LL+A+ +L +S + D++ G+ A+GR EQ E V G+F+N+L R++ G T+++L Sbjct: 1350 LLAAHVRVLSIISNQVDVLTGLVANGRPEQTDSEQVLGLFLNSLPFRLNLSG-GTWVDLI 1408 Query: 1568 DAVKHKVWSAMDKAQYPFDLLVEKVNPDRDLSRNPIYNVLFQF-----YDKLYLENEGIS 1622 V + +YP L R L P++ ++F F Y + N + Sbjct: 1409 RQVFDAEVELLPFRRYPLGQL------QRILGGQPLFEIIFNFVHFHVYQTVIELNNNVE 1462 Query: 1623 PFELSCLAQETN-------------QQIEISFEYNSDMYTDSTISRFAGYFLNIIGQVVD 1669 L + +ETN ++E+ F Y++ I + Y++ + +V Sbjct: 1463 LLGLKSV-EETNFTLAVNFKLNPGSSELEVGFAYDASELCREQIKAISSYYVKTLDAMVK 1521 Query: 1670 KPXXXXXXXXXXXXXXXXXXXSRFQGEQADLEDGQTIHGRFEAQVQKNPHAIALVYEEQQ 1729 +P + Q + IH FE QV++ P A+ALV+E QQ Sbjct: 1522 EPLESYELCSGLSTQEQYQLLEEWNDTQRNYLQDICIHQFFEMQVERTPDAVALVFENQQ 1581 Query: 1730 MTFQEVNGKANQLAWMLTGSGVQRNTPVGIFVDRSFSSVIGILAILKAGGAYVPLDPGYP 1789 +T++E+N +AN LA L GV+ + VG+ V+RS ++G+L ILKAGGAYVP+DP YP Sbjct: 1582 LTYRELNQQANHLAHYLRTLGVRVDVLVGLCVERSLEMLVGLLGILKAGGAYVPIDPEYP 1641 Query: 1790 EDRIAYILAHSGAKWLLTENRYLQSVAAFAHEEGIQIINLSPVKEQSAVSQMYLADYEDE 1849 ++RI++IL+ S LLT++R + + H+ + +I+ S EQ + Sbjct: 1642 QERISHILSDSQVSLLLTQHRLVARLP--EHQATLVVIDES--WEQII-----------Q 1686 Query: 1850 LSRENPRTGGHGPDRMYIMYTSGSTGKPKGVLVTHSNVLNFVTWSIGELQLQPKDALLLV 1909 S+ENP +G D + ++YTSGSTGKPKGV+V HS + N I L P +L Sbjct: 1687 HSQENPISGVKDSDLVNVIYTSGSTGKPKGVMVKHSGLCNLAQAQIDLFDLLPSSRILQF 1746 Query: 1910 TSISFDISVFEIFAALLSGSRLCIASMEHLKDTECLLAYMEAQHITIWHSVPSLMVQLMT 1969 S SFD S++E+ AL SG+RL + + E L L+ + IT PS + L Sbjct: 1747 ASFSFDASIWEVVMALGSGARLYLGTKESLLPGLELIELLRDYGITHITLPPSALAVL-- 1804 Query: 1970 LLRHHPGRYRHSPVLQQLRHLMLGGEAWSTSLAASLRETFPQAEIRNMYGPTEATIWVSS 2029 L L+++++ GEA + L +++ N YGPTE T+ + Sbjct: 1805 ----------PQAELPALQNIIVAGEACAPDL---IKQWSVGRRFFNAYGPTETTVCATV 1851 Query: 2030 YKPGPEIDESHPVMLIGRPIANNRLIILDQYGNVCPPGVAGEIYIAGNNVTQGYYNDEEK 2089 + G P IGRPI N + ILD Y P GV GE++I G V QGY N + Sbjct: 1852 AECGNGERSDKPP--IGRPIPNTQAYILDSYLQPVPIGVPGELHIGGAGVAQGYLNRPDL 1909 Query: 2090 TRMAFIPQ--SNGQI------FYKTGDSGRYLPEGNVEFTGRRDQLVKVRGYRIELGEIE 2141 T+ FIP +N + YKTGD RYLP+GN+E+ GR D VK+RG+RIELGEIE Sbjct: 1910 TQEKFIPNPFNNSKFKIQNSKLYKTGDLARYLPDGNIEYLGRIDHQVKIRGFRIELGEIE 1969 Query: 2142 QALKELTSLQQIAVTAVKD--GETSKIVCLYTGDQPVPQ-NQLKDAVRKRLPEYMIPAQF 2198 L + ++ Q+ V A +D G+ + L +P P N+L+ + +LPEYMIP+ F Sbjct: 1970 AILSQHPAILQVTVIAREDTPGDKCLVAYLALNQEPTPTINELRQFLGSKLPEYMIPSAF 2029 Query: 2199 FHVERFLLTPNGKMDWRSMEKFVRETPGSIEAAGI--RNEVDKKLSEIWKKLLGIPAVGI 2256 +E LTPNGK+D R++ + ET +E + R +++ L+ IW +L + +G+ Sbjct: 2030 VFLETLPLTPNGKVDRRALP--LPETLRELEVNFVAPRTPIEEILAPIWADVLRVEQIGV 2087 Query: 2257 QENFFDIGGNSLLVVQMQGMIQQEFFQDIPMMDLFKYTSIEKISDYLQEH 2306 +NFF++GG+SLL Q+ I+ F ++P+ LF+ +I +++Y+Q++ Sbjct: 2088 YDNFFELGGHSLLATQLVSRIRTTFKIELPLRSLFEAATIANLAEYIQQY 2137 Score = 444 bits (1143), Expect = e-122, Method: Compositional matrix adjust. Identities = 354/1109 (31%), Positives = 550/1109 (49%), Gaps = 110/1109 (9%) Query: 1263 PLSHAQRRIWFLQKMNPDLVAYNLPFIRYFDMAIDLELLQQAASFLAGRHLLMRTKYVLK 1322 PLS Q+ + F P+ Y + + +++ +QA + RH ++RT ++ + Sbjct: 18 PLSPMQQGMLFHTLYAPETGVYFQQLVCSLNGQLNISAFEQAWQRVIERHPVLRTLFLWE 77 Query: 1323 DGN-PVQEV-----LPAYVPAVQSIDAAGQSDP-ELFVKMNIHQQKMKPFNLEMPP-YRI 1374 + N P+Q V LP +S+ + Q + E F++ + + K F L P R Sbjct: 78 NRNKPLQVVRQIVNLPWTNYDWRSLSSIEQQEELENFLQAD----RDKGFELNQAPLMRC 133 Query: 1375 YLYTISDERACLYINFHHILTDGWSIDIYYRELFSLYQAFLHQQPPRL--PEVKEDYFDW 1432 L ++D + HH+L DGWSI +E+F+ Y AF L P EDY DW Sbjct: 134 TLIRVADYTYNFVWSHHHLLLDGWSIPTIIKEIFAFYDAFNEGNNLNLDKPRPYEDYIDW 193 Query: 1433 ILEQKAWEESEAFVEHEQFW---LKELAKPLPVL---SLPSDHKAPAVQTYRGSFHKFTI 1486 +Q + ++FW LK L P++ L + + P+ +Y + T Sbjct: 194 CQKQD-------ISQAKRFWQLQLKGLTATTPLIVDKPLIKNQEQPS--SYATQHAQLTE 244 Query: 1487 SGELYRKLKAHLETQQITANNFLLSAYFLLLHNLSQEQDIIIGVPASGRNEQ--KWESVA 1544 + L+A Q+T NN + A+ +LL S E D+I G SGR ES+ Sbjct: 245 PATI--ALQAFTRQHQLTLNNLVQGAWAILLSRYSGEVDVIFGATVSGRPPDIVGIESMV 302 Query: 1545 GIFINTLCIRIHFQGITTFMELQDAVKHKVWSAMDKAQYPFDLLVEKVNPDRDLSRNPIY 1604 G+FINTL IR+ + +E+ +K +++ Q+ ++ LVE + P++ Sbjct: 303 GLFINTLPIRV---SVPAEIEVLPWLKELQAQQVEREQHSYNQLVEIQSWTEIPKGMPLF 359 Query: 1605 N--VLFQFYD-KLYLENEGIS------------PFELSCLAQETNQQIEISFEYNSDMYT 1649 V+F+ Y +N GI+ P L+ + +Q+ + Y+SD + Sbjct: 360 ESIVVFENYPIDASEQNNGINISNVRSIERTNYPLNLAVIP---GRQLSVGISYDSDRFD 416 Query: 1650 DSTISRFAGYFLNIIGQVVDKPXXXXXXXXXXXXXXXXXXXSRFQGEQADLEDGQTIHGR 1709 +TISR G+F ++ + P S + Q Q IH Sbjct: 417 AATISRMLGHFQILLESLAANPHQHLNELPLLTKTEENQLLSEWNNTQTTYFQEQCIHEL 476 Query: 1710 FEAQVQKNPHAIALVYEEQQMTFQEVNGKANQLAWMLTGSGVQRNTPVGIFVDRSFSSVI 1769 FE QV+ +P AIA+VYE++Q+T+QE+N +ANQLA L GV VGI V+RS +I Sbjct: 477 FELQVECSPDAIAIVYEDEQLTYQELNNRANQLAHHLRNLGVGAEILVGICVERSIEMLI 536 Query: 1770 GILAILKAGGAYVPLDPGYPEDRIAYILAHSGAKWLLTENRYLQSVAAFAHEEGIQIINL 1829 GIL ILKAGGAYVPLDP YP++R+++ L S K L+T+ + L + AH+ + I+ Sbjct: 537 GILGILKAGGAYVPLDPNYPQERLSFSLEDSQVKVLITQQQLLSKLP--AHQAQVLCID- 593 Query: 1830 SPVKEQSAVSQMYLADYE--DELSRENPRTGGHGPDRMYIMYTSGSTGKPKGVLVTHSNV 1887 AD+E + S +NP+ + YI+YTSGSTGKPKGVL+ H+NV Sbjct: 594 --------------ADWEIIAQQSVQNPQIVTTSANLAYIIYTSGSTGKPKGVLINHANV 639 Query: 1888 LNFVTWSIGELQLQPKDALLLVTSISFDISVFEIFAALLSGSRLCIASMEHLKDTECLLA 1947 + T + +D L S +FD SV+EI+ AL+ G RL + + L Sbjct: 640 VRLFTATEEWFYFNQQDVWTLFHSFAFDFSVWEIWGALIKGGRLVVVPYWVSRSPADFLK 699 Query: 1948 YMEAQHITIWHSVPSLMVQLMTLLRHHPGRYRHSPVLQQLRHLMLGGEAWSTSLAASLRE 2007 ++ Q +T+ + PS QL+ + +P LR ++ GGEA SL+ Sbjct: 700 LLDKQKVTVLNQTPSAFRQLI-----QAEQLIDTPANLALRWVIFGGEALEIQ---SLKP 751 Query: 2008 TFPQ-----AEIRNMYGPTEATIWVSSYKPGPEID-ESHPVMLIGRPIANNRLIILDQYG 2061 F + ++ NMYG TE T+ V +Y+P D S+ +IG PI + ++ +LD+ Sbjct: 752 WFERHGDKYPQLVNMYGITETTVHV-TYRPITIADLSSNTGSVIGCPIPDLQVYVLDKAK 810 Query: 2062 NVCPPGVAGEIYIAGNNVTQGYYNDEEKTRMAFI--PQSN--GQIFYKTGDSGRYLPEGN 2117 + P GV GE+Y+ G ++ +GY N E T F+ P S+ YKTGD RYL G+ Sbjct: 811 QLLPIGVPGEMYVGGASLARGYLNRVELTSQVFVANPFSDDPNARLYKTGDLARYLENGD 870 Query: 2118 VEFTGRRDQLVKVRGYRIELGEIEQALKELTSLQQIAVTAVKD--GET------SKIVCL 2169 +E+ GR D VK+RG+RIELGEIE AL + +Q V A D G+T SK + Sbjct: 871 LEYLGRIDNQVKIRGFRIELGEIEAALTQHPQVQASVVIARVDTPGDTCTERSQSKRLVA 930 Query: 2170 YT---GDQPVPQNQLKDAVRKRLPEYMIPAQFFHVERFLLTPNGKMDWRSMEKFVRETPG 2226 Y Q + N L+ + +LPEYMIPA F ++ LT NGK+D R++ V +T Sbjct: 931 YLVIHQAQVLTVNDLRQFLDSKLPEYMIPAAFVFLDSLPLTSNGKVDRRALP--VPDTAR 988 Query: 2227 SIEAAGI--RNEVDKKLSEIWKKLLGIPAVGIQENFFDIGGNSLLVVQMQGMIQQEFFQD 2284 + E A + R +K L++IW ++LG+ VGI +NFF +GG+S+ +Q+Q Q++ Sbjct: 989 TEEKAFVAPRTPTEKLLTDIWAQVLGLEQVGINDNFFALGGDSIRSIQVQSQSQKQGL-S 1047 Query: 2285 IPMMDLFKYTSIEKISDYLQEHTVKVSSV 2313 + LF + +I + LQ +V+VS V Sbjct: 1048 FSLQQLFVHQTISNLVQELQ--SVEVSRV 1074 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.319 0.135 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 13,985,788,018 Number of extensions: 609028332 Number of successful extensions: 1656797 Number of sequences better than 1.0e-05: 23558 Number of HSP's gapped: 1550706 Number of HSP's successfully gapped: 34050 Length of query: 2331 Length of database: 3,060,696,203 Length adjustment: 152 Effective length of query: 2179 Effective length of database: 1,628,701,923 Effective search space: 3548941490217 Effective search space used: 3548941490217 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 140 (58.5 bits)