BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0486.0008.p (607 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value C0Z4C8.1 C0Z4C8_BREBN Probable two-component sensor histidine ki... 505 e-141 B3KCQ8.1 B3KCQ8_9BACI Histidine kinase internal region 475 e-132 B1DIU3.1 B1DIU3_9BACL Multi-sensor signal transduction histidine... 462 e-128 C1I2X2.1 C1I2X2_9CLOT Multi-sensor signal transduction histidine... 387 e-105 A6M1Q9.1 A6M1Q9_CLOB8 Multi-sensor signal transduction histidine... 379 e-103 >C0Z4C8.1 C0Z4C8_BREBN Probable two-component sensor histidine kinase EC=2.7.3.- Length = 587 Score = 505 bits (1300), Expect = e-141, Method: Compositional matrix adjust. Identities = 266/544 (48%), Positives = 364/544 (66%), Gaps = 6/544 (1%) Query: 52 MLYXXXXXXXXXXXXXXMQQIIEQVNYNLDLYAKGMANIFATAEEHITASPSIDSPLLSE 111 MLY QQI+EQV YNLD Y GM IF ++ I S + + LSE Sbjct: 35 MLYGKFAQTAEQNAYLHTQQILEQVKYNLDSYLNGMTQIFELVDDKIRRSKGLTADKLSE 94 Query: 112 RMDTLMSSREDLVSIAVFTPQGKYVVGTPGQNMRINTQLQSQSWFTSAVKNP-EISYSAP 170 +++T++ +R+D+VSIAVFT +G + TP + +R NT+L QSWF A+++P +++S P Sbjct: 95 QLETIVETRKDIVSIAVFTREGTLLATTPSKVLRQNTRLTEQSWFQKAIEDPTNMNFSLP 154 Query: 171 HIQNLFKGRYTWVVSISK-MIEYKENGQIRKGILLIDFNFRTIDELSRQVKLGKRGYAYI 229 HIQNLFKG YTWVVS+S+ ++ + +G+I +LL+D NF+ ID+L ++V LGK+GY YI Sbjct: 155 HIQNLFKGEYTWVVSMSREILLHGPDGEI-PTVLLVDVNFKEIDDLCQRVGLGKKGYVYI 213 Query: 230 LDPLGNIVYHPQQQLIYAGLKYENVEPVLEYKFRSYLDESTGEKRFITVRTLDLTGWKIV 289 +D +GNIVYHPQQQLIYAGLK EN L++ + SY++E+ E R IT++T+D GWKI+ Sbjct: 214 IDLVGNIVYHPQQQLIYAGLKNENRSLPLKHSYGSYVEETEDEARLITIKTIDQLGWKII 273 Query: 290 GVAYYDEIVTTKRDLNHFLAWFXXXXXXXXXXXXXXXXXXXASPIRKLERTVKLVGEGDL 349 GV+Y DEIVTTK++++ F+ W + PI+ LER+++ V +GD Sbjct: 274 GVSYMDEIVTTKKEISRFIFWLLIFVIVIVLFVLHYLSAKISRPIKLLERSMEKVEQGDF 333 Query: 350 NTPINVSGAYEVEQLSRRFNMMLQRIRQLMDQIIYEQETKRKGELEVLQSQINPHFLYNT 409 + + G++EVEQLS RF++M+ ++R+LM QII EQE KRK ELEVLQ+QINPHFLYNT Sbjct: 334 SESEPIRGSHEVEQLSLRFHLMVAKVRELMHQIIREQEAKRKSELEVLQAQINPHFLYNT 393 Query: 410 LNSVIRLAERGKTDEVVTMIQSLSKFFRISLSKGKNMITMQEELDHIRHYLVIQSFRFKN 469 LNSV+R+ GK ++V+T I SLSK FRISLS+GKN+IT++EELDH RHYL+IQ R+K Sbjct: 394 LNSVVRMVGNGKNEDVITTITSLSKLFRISLSRGKNIITVREELDHARHYLIIQKMRYKQ 453 Query: 470 KFRYEISA--EEEVLACQTIKLILQPIVENALYHGIEMLPDEGLITITAELVEGLIIIRV 527 KF YEI E+EVL C T+KL+LQPIVENA+YHGIE L D G I I A +++G ++++V Sbjct: 454 KFEYEIVVENEDEVLNCLTLKLLLQPIVENAIYHGIEHLADPGRIRIFAAIIDGKVLLQV 513 Query: 528 SDNGLGMX-XXXXXXXXXXXXXXXXXXXXXXXXXXXIGLVYGREYGLAFESELEEGTTVT 586 SDNGLGM I L +G +YGL SE EEGT V Sbjct: 514 SDNGLGMSPDVLAQVKAGFYKSEEGSGVGIQNVQERIRLTFGEQYGLEIASEQEEGTVVR 573 Query: 587 ICFP 590 + P Sbjct: 574 VWIP 577 >B3KCQ8.1 B3KCQ8_9BACI Histidine kinase internal region Length = 610 Score = 475 bits (1222), Expect = e-132, Method: Compositional matrix adjust. Identities = 253/545 (46%), Positives = 343/545 (62%), Gaps = 14/545 (2%) Query: 70 QQIIEQVNYNLDLYAKGMANIFATAEEHITASPSIDSPLLSERMDTLMSSREDLVSIAVF 129 QQI++QV+YNL+ Y GMA ++ EE++ A D +++++DT+M SR+D+VSIA+F Sbjct: 67 QQIVDQVSYNLEDYVDGMAQLYRAIEENMLADGQWDDEQVTKQLDTIMRSRDDIVSIALF 126 Query: 130 TPQGKYVVGTPGQNMRINTQLQSQSWFTSAVK-NPEISYSAPHIQNLFKGRYTWVVSISK 188 QG + P ++ + ++ QSWF SA++ + +S+S PH+QNL+ + WVV++SK Sbjct: 127 NDQGDMLRNHPAIPVKPSAKVTEQSWFHSAMRVSDHLSFSLPHVQNLYDQTFEWVVTMSK 186 Query: 189 MIEYKENGQIRKGILLIDFNFRTIDELSRQVKLGKRGYAYILDP-LGNIVYHPQQQLIYA 247 I +G+ ILL+D NF+ IDELS ++ LGKRGYAYI+D GNIVYHPQQQLIY Sbjct: 187 GITVVHDGEPMYVILLVDINFKKIDELSSRISLGKRGYAYIIDEGAGNIVYHPQQQLIYM 246 Query: 248 GLKYENVEPVLEYKFRSYLDESTGEKRFITVRTLDLTGWKIVGVAYYDEIVTTKRDLNHF 307 GL+ E+VE L SY+DES G KR TV+++ GWKIVGV+Y DEI+TT+ ++N + Sbjct: 247 GLRNESVERALTSS-ESYIDESDGVKRLNTVKSVVNIGWKIVGVSYLDEIMTTREEVNRY 305 Query: 308 LAWFXXXXXXXXXXXXXXXXXXXASPIRKLERTVKLVGEGDLNTPINVSGAYEVEQLSRR 367 L PIR++ RT+K V GD + + + G EV QLS R Sbjct: 306 LVRVVAIVLVLAIAVSLILSAMLTRPIRRMGRTMKAVERGDFDVELPLQGPLEVVQLSSR 365 Query: 368 FNMMLQRIRQLMDQIIYEQETKRKGELEVLQSQINPHFLYNTLNSVIRLAERGKTDEVVT 427 FN+ML +IRQLM QI+ EQE+KRK ELE LQ+QINPHFLYNTLNSV+R+ K +EV+T Sbjct: 366 FNLMLNKIRQLMKQIVKEQESKRKYELEALQAQINPHFLYNTLNSVVRMVGMSKKEEVIT 425 Query: 428 MIQSLSKFFRISLSKGKNMITMQEELDHIRHYLVIQSFRFKNKFRYEISAEEEVLACQTI 487 MI SLSK FR+SLSKGK I+++EEL+H RHYL IQ R+K KF + I A+E L+C T+ Sbjct: 426 MITSLSKLFRLSLSKGKTSISVREELEHARHYLTIQQMRYKQKFDFAIEADEAALSCYTL 485 Query: 488 KLILQPIVENALYHGIEMLPDEGLITITAELVEGLIIIRVSDNGLGMXXXXXXXXXXXXX 547 KL+LQP++ENA+ HGIE + D+G I I A + + + V+DNG+GM Sbjct: 486 KLVLQPLIENAIVHGIEYMVDQGHIRIGAAVKGEWLEMTVTDNGVGMTPEMVEGILDAKE 545 Query: 548 X---------XXXXXXXXXXXXXXIGLVYGREYGLAFESELEEGTTVTICFPAVQAGTEP 598 I L YG+ YGL FESE E GTTV I P + Sbjct: 546 TPHNPVQFINTAGSGVAVRNVHDRIRLYYGKRYGLEFESEQEAGTTVRIRIPVIH--DMD 603 Query: 599 EEGRE 603 EEGRE Sbjct: 604 EEGRE 608 >B1DIU3.1 B1DIU3_9BACL Multi-sensor signal transduction histidine kinase Length = 586 Score = 462 bits (1190), Expect = e-128, Method: Compositional matrix adjust. Identities = 250/537 (46%), Positives = 341/537 (63%), Gaps = 5/537 (0%) Query: 70 QQIIEQVNYNLDLYAKGMANIFATAEEHITASPSIDSPLLSERMDTLMSSREDLVSIAVF 129 QQI++QV+Y+L+ + +++F IT S +DS L ++ T+MS+R D VS+A+F Sbjct: 49 QQIVDQVSYSLENNVQATSDLFNMMYHTITQSGDVDSESLHRQLATMMSTRADTVSLALF 108 Query: 130 TPQGKYVVGTPGQNMRINTQLQSQSWFTSAVKNP-EISYSAPHIQNLFKGRYTWVVSISK 188 +G+ V+ P M+ + S+SWF SA+ P +S S PH+QNL+K ++ WVVS+SK Sbjct: 109 DDKGQLVMDLPDVTMKNALDVTSESWFQSALDTPSHLSISLPHVQNLYKEQFRWVVSLSK 168 Query: 189 MIEYKENGQIRKGILLIDFNFRTIDELSRQVKLGKRGYAYILD-PLGNIVYHPQQQLIYA 247 I NG+ +G+LL+D NF TIDELS +V LG++GY YILD GNIVYHPQ QLIYA Sbjct: 169 SITMIHNGKPIQGVLLLDVNFNTIDELSDRVSLGEKGYVYILDESAGNIVYHPQLQLIYA 228 Query: 248 GLKYENVEPVLEYKFRSYLDESTGEKRFITVRTLDLTGWKIVGVAYYDEIVTTKRDLNHF 307 GLK ENVE L++ + SY+D+++ + I+V+T+ GWK+VGV+Y DE +T+ +LN Sbjct: 229 GLKNENVELALKHTYGSYIDKTSSATKIISVQTIGNVGWKVVGVSYRDEAMTSISELNRS 288 Query: 308 LAWFXXXXXXXXXXXXXXXXXXXASPIRKLERTVKLVGEGDLNTPINVSGAYEVEQLSRR 367 + + PI++LE ++K V G+ G EV QL+ R Sbjct: 289 MFQLLLALILIVVLLSSIVSRRISKPIKQLELSMKNVEHGNFEQTAIGEGPLEVRQLADR 348 Query: 368 FNMMLQRIRQLMDQIIYEQETKRKGELEVLQSQINPHFLYNTLNSVIRLAERGKTDEVVT 427 FN+M+ I++LM QI+ EQE+KR ELE LQ+QINPHFLYNTLNSV+R+ K +EV T Sbjct: 349 FNIMISTIKKLMRQIVTEQESKRTYELEALQAQINPHFLYNTLNSVVRMVGMNKNEEVTT 408 Query: 428 MIQSLSKFFRISLSKGKNMITMQEELDHIRHYLVIQSFRFKNKFRYEISAEEEVLACQTI 487 MI SLSK FRISL KGK++IT+ +EL+H R+YLVIQ RFKNKF + I A+ EVL T+ Sbjct: 409 MITSLSKLFRISLGKGKSIITIADELEHARNYLVIQQMRFKNKFDFSIKADGEVLNYATL 468 Query: 488 KLILQPIVENALYHGIEMLPDEGLITITAELVEGLIIIRVSDNGLGMXXXXXXXXXX-XX 546 KLI+QP++ENAL HGIE D+G I + A++ I+I V DNGLGM Sbjct: 469 KLIVQPLIENALVHGIEPSVDKGHIWVEAKVDCDDIVIEVRDNGLGMSEERLKQVTAGQV 528 Query: 547 XXXXXXXXXXXXXXXXIGLVYGREYGLAFESELEEGTTVTICFPAVQAGTEPEEGRE 603 I L YG+ YGL F SELEEGTTVTI FPA++ + EGRE Sbjct: 529 TSSKGSGVGVMNVQERIRLFYGQAYGLHFASELEEGTTVTIRFPAME--LKQAEGRE 583 >C1I2X2.1 C1I2X2_9CLOT Multi-sensor signal transduction histidine kinase Length = 597 Score = 387 bits (995), Expect = e-105, Method: Compositional matrix adjust. Identities = 205/531 (38%), Positives = 313/531 (58%), Gaps = 7/531 (1%) Query: 70 QQIIEQVNYNLDLYAKGMANIFATAEEHITASPSIDSPLLSERMDTLMSSRED-LVSIAV 128 + I+EQVN NLD Y + M I T + + + MD + + +D L+SI++ Sbjct: 58 KSILEQVNLNLDSYLRKMMKISDTIYYRAIKKTDLSDENIDKEMDLIYEANKDYLISISL 117 Query: 129 FTPQGKYVVGTPGQNMRINTQLQSQSWFTSAV-KNPEISYSAPHIQNLFKG---RYTWVV 184 F+ G+ + P Q ++ N + WF SA+ K + +S PH+QNLF +YTWVV Sbjct: 118 FSDYGEVIASYPLQQLKNNIDPRESEWFQSAISKRENLHFSTPHVQNLFYDPNYKYTWVV 177 Query: 185 SISKMIEYKENGQIRKGILLIDFNFRTIDELSRQVKLGKRGYAYILDPLGNIVYHPQQQL 244 S+S+ +E E+G+I G+LL+D NF I+++ + V +GK GY Y++D G I+YHP+QQL Sbjct: 178 SLSRAVEITESGRINGGVLLVDMNFSGIEQICKNVDMGKNGYVYLIDRDGEIIYHPRQQL 237 Query: 245 IYAGLKYENVEPVLEYKFRSYLDESTGEKRFITVRTLDLTGWKIVGVAYYDEIVTTKRDL 304 IY+ L EN +Y+ +++++ G+KR +TV+T+ TGWKIV ++ +I ++ Sbjct: 238 IYSDLIKENNYEAAKYEDGNHVEKFEGDKRLVTVKTVGYTGWKIVAISPMTDITADYYEI 297 Query: 305 NHFLAWFXXXXXXXXXXXXXXXXXXXASPIRKLERTVKLVGEGDLNTPINVSGAYEVEQL 364 F + A+PI++LE++V G +N I+ SG+YE++ L Sbjct: 298 RVFAIFMMFFAIFTLISINMFVSSRIANPIKELEKSVNEFENGVVNLNISESGSYEIQHL 357 Query: 365 SRRFNMMLQRIRQLMDQIIYEQETKRKGELEVLQSQINPHFLYNTLNSVIRLAERGKTDE 424 + M++++ LM+ I+ EQE KRK EL LQ+QINPHFLYNTL+S+I + E D Sbjct: 358 GKAIKSMVKQMNMLMENIMNEQEAKRKSELNALQAQINPHFLYNTLDSIIWMIENENYDG 417 Query: 425 VVTMIQSLSKFFRISLSKGKNMITMQEELDHIRHYLVIQSFRFKNKFRYEISAEEEVLAC 484 + M+ +L++FFRISLSKGKN+IT+++EL+H R+YL IQ+ R+KNKF Y+I AEEEVL Sbjct: 418 AIVMVTALARFFRISLSKGKNVITVKDELEHARYYLTIQNIRYKNKFTYDIKAEEEVLNL 477 Query: 485 QTIKLILQPIVENALYHGIEMLPDEGLITITAELVEGLIIIRVSDNGLGM--XXXXXXXX 542 +IKLI+QP++ENA+YHG+E + +G I + A L + I + DNGLGM Sbjct: 478 TSIKLIIQPLIENAIYHGMEYMSGDGDILVQAYLKNDELYIDIIDNGLGMPQEVADKLLT 537 Query: 543 XXXXXXXXXXXXXXXXXXXXIGLVYGREYGLAFESELEEGTTVTICFPAVQ 593 I L +G YGL SE +EGTT+ I P++ Sbjct: 538 NENGVQKKGSGIGLRNVHERIKLYFGDSYGLEIYSEPDEGTTIRIHMPSID 588 >A6M1Q9.1 A6M1Q9_CLOB8 Multi-sensor signal transduction histidine kinase Length = 602 Score = 379 bits (974), Expect = e-103, Method: Compositional matrix adjust. Identities = 200/531 (37%), Positives = 306/531 (57%), Gaps = 7/531 (1%) Query: 70 QQIIEQVNYNLDLYAKGMANIFATAEEHITASPSIDSPLLSERMDTLMSSRED-LVSIAV 128 + +++QVN NLD Y + M + T ++ + + + + MD L + +D L+SI Sbjct: 61 KSMLDQVNLNLDSYLRNMMKVSDTTYYNVIKKKDLATDTIDKEMDLLYETNKDSLISICT 120 Query: 129 FTPQGKYVVGTPGQNMRINTQLQSQSWFTSAVKNPE-ISYSAPHIQNLFKG---RYTWVV 184 F+ G+ + +P + ++ + + WFT A+ E + +S PH+QNLF +Y WVV Sbjct: 121 FSQDGEVIAASPVKQLKSSIDPRVSDWFTKAIDKKENLHFSTPHVQNLFVDPDYKYRWVV 180 Query: 185 SISKMIEYKENGQIRKGILLIDFNFRTIDELSRQVKLGKRGYAYILDPLGNIVYHPQQQL 244 S+S+ IE N + G+LL+D NF I+++ + +GK GY Y++D G I+YHP+QQL Sbjct: 181 SLSRAIELTNNKKTTSGVLLVDINFSGIEQICKNANIGKSGYVYLVDREGEIIYHPRQQL 240 Query: 245 IYAGLKYENVEPVLEYKFRSYLDESTGEKRFITVRTLDLTGWKIVGVAYYDEIVTTKRDL 304 IY+ L EN + Y ++++ GEKR +TV+T+ TGWKIVG+ +I + + Sbjct: 241 IYSDLIDENNKIEAAYDDGNHIETFRGEKRLVTVKTVGYTGWKIVGITPMLDITSDYYQM 300 Query: 305 NHFLAWFXXXXXXXXXXXXXXXXXXXASPIRKLERTVKLVGEGDLNTPINVSGAYEVEQL 364 + F + A+PIR LE+ VK + G + +++SG+YEV+ L Sbjct: 301 SIFAVFIMSFAIFILVFLNMFVSSRIANPIRLLEKCVKKLENGVKDVDVSISGSYEVQHL 360 Query: 365 SRRFNMMLQRIRQLMDQIIYEQETKRKGELEVLQSQINPHFLYNTLNSVIRLAERGKTDE 424 + M+ ++ LMD I+ EQE+KRK EL LQ+QINPHFLYNTL+S+I + E D Sbjct: 361 GKAIRSMVNQMHTLMDNIMIEQESKRKSELNALQAQINPHFLYNTLDSIIWMIENENYDG 420 Query: 425 VVTMIQSLSKFFRISLSKGKNMITMQEELDHIRHYLVIQSFRFKNKFRYEISAEEEVLAC 484 + M+ +L+K FRISLSKGKN+IT+++E++H R+YL IQ+ R+KNKF Y I +E+VL Sbjct: 421 AIIMVTALAKLFRISLSKGKNIITVRDEIEHARNYLTIQNIRYKNKFTYNIEVDEKVLNY 480 Query: 485 QTIKLILQPIVENALYHGIEMLPDEGLITITAELVEGLIIIRVSDNGLGMXXXXXXXXXX 544 +IKLI+QP++ENA+YHG+E + +G I + A + + I V DNGLGM Sbjct: 481 GSIKLIIQPLIENAIYHGMEFMGGDGEILVKAYAKDNELYIDVVDNGLGMLQDVANSLLT 540 Query: 545 --XXXXXXXXXXXXXXXXXXIGLVYGREYGLAFESELEEGTTVTICFPAVQ 593 I L +G+ YGL SE +EGTTV I P V Sbjct: 541 GESKIEKKSSGIGLKNVNERIQLYFGKRYGLEIYSEPDEGTTVRIHMPCVD 591 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.319 0.136 0.385 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,791,539,495 Number of extensions: 103949850 Number of successful extensions: 295283 Number of sequences better than 1.0e-05: 2401 Number of HSP's gapped: 292663 Number of HSP's successfully gapped: 2403 Length of query: 607 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 465 Effective length of database: 1,722,912,073 Effective search space: 801154113945 Effective search space used: 801154113945 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 134 (56.2 bits)