BLASTP 2.2.18 [Mar-02-2008]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0476.0056.p
         (78 letters)

Database: pfamseq 
           9,421,015 sequences; 3,060,696,203 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

B2U8M4.1 B2U8M4_RALPJ Thymidylate synthase EC=2.1.1.45                133   5e-30
B3K6M8.1 B3K6M8_9BACI Thymidylate synthase EC=2.1.1.45                132   8e-30
A7CMA1.1 A7CMA1_BURPI Thymidylate synthase EC=2.1.1.45                132   9e-30
A4SIW7.1 TYSY_AERS4 Thymidylate synthase EC=2.1.1.45                  132   1e-29
C1ZTQ2.1 C1ZTQ2_RHOMR Thymidylate synthase EC=2.1.1.45                130   4e-29

>B2U8M4.1 B2U8M4_RALPJ Thymidylate synthase EC=2.1.1.45
          Length = 264

 Score =  133 bits (335), Expect = 5e-30,   Method: Compositional matrix adjust.
 Identities = 57/78 (73%), Positives = 69/78 (88%)

Query: 1   MVAQQTGLEVGEFIWSGGDVHIYTNHLEQVATQLAREPYPLPKLVIRRQPESIFDYTFED 60
           MVAQQTGL+VG+F+W+GGD H+Y NH EQV TQLAREP PLPKL+I+R+PESIFDY +ED
Sbjct: 187 MVAQQTGLDVGDFVWTGGDCHLYNNHFEQVQTQLAREPLPLPKLIIKRKPESIFDYQYED 246

Query: 61  FEFVGYEHHPGIKAPVAI 78
           FE +GY+ HP IKAPVA+
Sbjct: 247 FEILGYQSHPAIKAPVAV 264


>B3K6M8.1 B3K6M8_9BACI Thymidylate synthase EC=2.1.1.45
          Length = 264

 Score =  132 bits (333), Expect = 8e-30,   Method: Compositional matrix adjust.
 Identities = 61/78 (78%), Positives = 69/78 (88%)

Query: 1   MVAQQTGLEVGEFIWSGGDVHIYTNHLEQVATQLAREPYPLPKLVIRRQPESIFDYTFED 60
           MVAQQ  LE GEFIWSGGDVHIY+NH+EQV TQL REPY LPKLVI+R+P+SIFDYTFED
Sbjct: 187 MVAQQCDLEPGEFIWSGGDVHIYSNHMEQVRTQLEREPYALPKLVIKRKPDSIFDYTFED 246

Query: 61  FEFVGYEHHPGIKAPVAI 78
           FEF GY++HP IKA VA+
Sbjct: 247 FEFEGYQYHPTIKATVAV 264


>A7CMA1.1 A7CMA1_BURPI Thymidylate synthase EC=2.1.1.45
          Length = 326

 Score =  132 bits (332), Expect = 9e-30,   Method: Compositional matrix adjust.
 Identities = 58/78 (74%), Positives = 68/78 (87%)

Query: 1   MVAQQTGLEVGEFIWSGGDVHIYTNHLEQVATQLAREPYPLPKLVIRRQPESIFDYTFED 60
           MVAQQTGL+VG+F+W+GGD H+Y NH EQV TQLAREP PLPKL I+R+PESIFDY +ED
Sbjct: 249 MVAQQTGLDVGDFVWTGGDCHLYNNHFEQVETQLAREPLPLPKLHIKRKPESIFDYQYED 308

Query: 61  FEFVGYEHHPGIKAPVAI 78
           FE VGY+ HP IKAPVA+
Sbjct: 309 FEIVGYQSHPAIKAPVAV 326


>A4SIW7.1 TYSY_AERS4 Thymidylate synthase EC=2.1.1.45
          Length = 264

 Score =  132 bits (332), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 55/78 (70%), Positives = 69/78 (88%)

Query: 1   MVAQQTGLEVGEFIWSGGDVHIYTNHLEQVATQLAREPYPLPKLVIRRQPESIFDYTFED 60
           M+AQQ  LEVG+F+W+GGDVH+Y+NH+EQ A QL+REP PLP+L I+R+P+SIFDY FED
Sbjct: 187 MMAQQCDLEVGDFVWTGGDVHLYSNHMEQTALQLSREPRPLPQLAIKRKPDSIFDYRFED 246

Query: 61  FEFVGYEHHPGIKAPVAI 78
           FE +GY+ HPGIKAPVAI
Sbjct: 247 FEILGYDPHPGIKAPVAI 264


>C1ZTQ2.1 C1ZTQ2_RHOMR Thymidylate synthase EC=2.1.1.45
          Length = 283

 Score =  130 bits (326), Expect = 4e-29,   Method: Compositional matrix adjust.
 Identities = 58/78 (74%), Positives = 67/78 (85%)

Query: 1   MVAQQTGLEVGEFIWSGGDVHIYTNHLEQVATQLAREPYPLPKLVIRRQPESIFDYTFED 60
           M+AQQT L+VGEFIW+GGD HIY NHLEQV   L+REPYPLPKLVI+R+P SIFDY +ED
Sbjct: 206 MIAQQTDLDVGEFIWTGGDCHIYLNHLEQVEELLSREPYPLPKLVIKRRPPSIFDYRYED 265

Query: 61  FEFVGYEHHPGIKAPVAI 78
           FEFV Y HHP IKAP+A+
Sbjct: 266 FEFVNYRHHPPIKAPIAV 283


  Database: pfamseq
    Posted date:  Aug 5, 2010  3:22 PM
  Number of letters in database: 3,060,696,203
  Number of sequences in database:  9,421,015
  
Lambda     K      H
   0.321    0.141    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 9421015
Number of Hits to DB: 506,900,326
Number of extensions: 17403762
Number of successful extensions: 35846
Number of sequences better than 1.0e-05: 1184
Number of HSP's gapped: 35733
Number of HSP's successfully gapped: 1184
Length of query: 78
Length of database: 3,060,696,203
Length adjustment: 49
Effective length of query: 29
Effective length of database: 2,599,066,468
Effective search space: 75372927572
Effective search space used: 75372927572
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 125 (52.8 bits)