BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0476.0028.p (1145 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3K6R1.1 B3K6R1_9BACI Methionine synthase 1863 0.0 C0ZBM1.1 C0ZBM1_BREBN 5-methyltetrahydrofolate--homocysteine met... 1602 0.0 C1PC51.1 C1PC51_BACCO Methionine synthase 1501 0.0 Q9KCE1.1 Q9KCE1_BACHD 5-methyltetrahydrofolate S-homocysteine me... 1496 0.0 Q2BAQ5.1 Q2BAQ5_9BACI 5-methyltetrahydrofolate--homocysteine S-m... 1492 0.0 >B3K6R1.1 B3K6R1_9BACI Methionine synthase Length = 1146 Score = 1863 bits (4826), Expect = 0.0, Method: Compositional matrix adjust. Identities = 905/1143 (79%), Positives = 1004/1143 (87%), Gaps = 1/1143 (0%) Query: 3 KFTLAESLQQRILILDGAMGTMIQQVPLTGADFGGEELDGCNEMLVLTRPELIQGIHEKY 62 K +L E L++RILILDGAMGTMIQQ L+ DFGG ELDGCNEMLV+ RP++IQ IHE+Y Sbjct: 3 KPSLQEVLKERILILDGAMGTMIQQEDLSAEDFGGPELDGCNEMLVIHRPDVIQKIHEQY 62 Query: 63 LEAGADLIETNTFGATSVVLAEYDIPQRAREINLEAARLARNAVDKYDTPDRPRYVIGAM 122 LEAGADLIETNTFGATSVVLAEYDIP+ AREINL+AA LAR AV+KY TPD PRYV+GAM Sbjct: 63 LEAGADLIETNTFGATSVVLAEYDIPELAREINLKAAHLARAAVEKYSTPDSPRYVVGAM 122 Query: 123 GPTTKTLSVTGGVTFQELVQSYEEQAAALIDGKVDALLLETSQDTLNVKAGSIGIRNAFE 182 GPTTKTLSVTGGVTF EL++SYEEQA ALI+G VDALLLETSQDTLNVKAGSIGIR AF+ Sbjct: 123 GPTTKTLSVTGGVTFAELIESYEEQAVALIEGGVDALLLETSQDTLNVKAGSIGIRQAFD 182 Query: 183 RSGITLPVMISGTIEPMGTTLAGQNIEAFYISLEHLKPISIGLNCATGPEFMRDHIRSLS 242 ++G+TLP+MISGTIEPMGTTLAGQNIEAFYISLEHL P+SIGLNCATGPEFMRDHIRSLS Sbjct: 183 KTGVTLPIMISGTIEPMGTTLAGQNIEAFYISLEHLNPVSIGLNCATGPEFMRDHIRSLS 242 Query: 243 AISSAAVSCYPNAGLPDENGNYHESPDSLARKLAGFAEKGWLNIAGGCCGTTPDHIRAMA 302 +S +A+SCYPNAGLPDENG YHESP+SLA+K+ FAEKGWLNIAGGCCGTTPDHIRA+ Sbjct: 243 EMSRSAISCYPNAGLPDENGQYHESPESLAQKMGAFAEKGWLNIAGGCCGTTPDHIRALK 302 Query: 303 EVLAEYPPRGLDGQHPPALSGIEPVYIESDNRPYMVGERTNVLGSRKFKRLIVEGKYEEA 362 + + + PR L+G H PALSGIEPVYIE +NRPYMVGERTNVLGSRKFKRLIVEGKYEEA Sbjct: 303 QTMDGFTPRPLEGGHLPALSGIEPVYIEQENRPYMVGERTNVLGSRKFKRLIVEGKYEEA 362 Query: 363 SEIARAQVKNGAQVIDVCVQDPDRDESADITKFLELXXXXXXXPLMIDTTDPKVIDLALQ 422 SEIARAQVKNGA VIDVCVQDPDR+E+ D+ +FLEL PLMIDTTDP VIDLALQ Sbjct: 363 SEIARAQVKNGAHVIDVCVQDPDREEAEDMIQFLELVVKKVKVPLMIDTTDPAVIDLALQ 422 Query: 423 YSQGKAIINSINLEDGEEKFELVTPLIHKYGAAIVVGTIDESGQAIKAADKLNVAKRSYE 482 YSQGKAIINSINLEDGEEKFE VTPL+HKYGAA+VVGTIDESGQAI DKL VA+RSY+ Sbjct: 423 YSQGKAIINSINLEDGEEKFEHVTPLVHKYGAAVVVGTIDESGQAIHRDDKLKVAQRSYD 482 Query: 483 LLVNKYGLAPEDLIFDTLVFPVGTGDEQYIGSAKETIDGIRLIKEALPEVHTILGISNVS 542 LLVNKYG++PED+IFDTLVFPVGTGDEQYIGSAKETI+GIR+IKEA+P+VHTILGISNVS Sbjct: 483 LLVNKYGISPEDIIFDTLVFPVGTGDEQYIGSAKETIEGIRMIKEAMPKVHTILGISNVS 542 Query: 543 FGLPEAGREVLNSVFLYECTKAGLDYAIVNTEKVERYASIPEQERYLAEQLIYNTNDDTL 602 FGLPEAGREVLNSV+LYECTKAGLDYAIVNTEK+ERYASIPE+ER LAE LIY TND+TL Sbjct: 543 FGLPEAGREVLNSVYLYECTKAGLDYAIVNTEKLERYASIPEEERRLAEDLIYRTNDETL 602 Query: 603 SAFVAAFRGKKVEKKEKISNLSLEERLASYVVEGTKEGLIPDLNEALTKSGPLEIINGPL 662 +AFVAAFR KKVEKK K+SNL+LEERLASYVVEG+KEGLIPDL+EALTK G LEIINGPL Sbjct: 603 AAFVAAFRHKKVEKKVKVSNLTLEERLASYVVEGSKEGLIPDLDEALTKYGALEIINGPL 662 Query: 663 MAGMSEVGRLFNNNELIVAEVLQSAEVMKASVSHLEQFMQKDETSVKGKIMLATVKGDVH 722 MAGM+EVGRLFNNNELIVAEVLQSAEVMKASV++LE FM+K+E+SVKGKIMLATVKGDVH Sbjct: 663 MAGMTEVGRLFNNNELIVAEVLQSAEVMKASVAYLESFMEKNESSVKGKIMLATVKGDVH 722 Query: 723 DIGKNLVEIILSNNGYEIINLGIKVPPESIIEAFRREKADAIGLSGLLVKSAQQMVLTAQ 782 DIGKNLVEIILSNNGY+IINLGIKVPPE IIEA+RRE+ DAIGLSGLLVKSAQQMV TAQ Sbjct: 723 DIGKNLVEIILSNNGYQIINLGIKVPPEQIIEAYRREQPDAIGLSGLLVKSAQQMVSTAQ 782 Query: 783 DLRTAGIDVPIMVGGAALTRKFTKTRIRPEYDGLVLYAKDAMDGLDIANRLMNPEERVKI 842 DL+ AGI VPIMVGGAALTRKFTKTRIRPEYDG+VLYAKDAMDGL +AN+L +P R ++ Sbjct: 783 DLKNAGISVPIMVGGAALTRKFTKTRIRPEYDGMVLYAKDAMDGLALANQLSDPVLRTQM 842 Query: 843 XXXXXXXXXXXXXX-XXXXXXXXLTRAVRSKISPDAPVFTPPDLERHVLRNYPLGHIIPY 901 L+ +RSKIS +APV+ PPD+ERHVLRNYP+ HI+PY Sbjct: 843 AEEIKAEQEADAAAPQVVKVMPKLSEGLRSKISTEAPVYIPPDMERHVLRNYPISHILPY 902 Query: 902 VNMQMLLGHHLGLKGSVEAQLAAGDPRTVELKETVDEILHHAMLEGTMTPHAMYQFFPAQ 961 +NMQMLLGHHLGLKGSVE L A DP+ V LKETVD IL A+ G + HAMY+FFPAQ Sbjct: 903 INMQMLLGHHLGLKGSVEQLLKANDPKAVSLKETVDGILEEAVQSGIIQAHAMYRFFPAQ 962 Query: 962 SKGNDILIYDPQDTATVLHTFTFPRQNVEPYLCLADFLKSVDSGIMDYVGFLVVTAGHGI 1021 S+GNDI+IYDP+D + +LHTFTFPRQ VEPYLCLADFLKSV+SG+MDYVGFLVVTAGHG+ Sbjct: 963 SRGNDIIIYDPKDASKILHTFTFPRQQVEPYLCLADFLKSVESGVMDYVGFLVVTAGHGV 1022 Query: 1022 REMSAELRDKGDYLRSHXXXXXXXXXXXXXXXXXHHMMRDTWGFPDPADMTMKQRHGARY 1081 ++S E +DKGDYLRSH HHMMRDTWG+PDPADMTMKQR GARY Sbjct: 1023 GKLSGEWKDKGDYLRSHALQSVALETAEGLAERIHHMMRDTWGYPDPADMTMKQRLGARY 1082 Query: 1082 QGIRVSFGYPACPDLEDQGPLFKLMSPGDIGVELTEGFMMEPEASVSAMVFAHPEAQYFN 1141 QGIRVSFGYPACPDLEDQ PLFKLM P DIGV LTEGFMMEPEASVSAMVF+HPEA YFN Sbjct: 1083 QGIRVSFGYPACPDLEDQEPLFKLMQPEDIGVHLTEGFMMEPEASVSAMVFSHPEAHYFN 1142 Query: 1142 VEK 1144 V+K Sbjct: 1143 VDK 1145 >C0ZBM1.1 C0ZBM1_BREBN 5-methyltetrahydrofolate--homocysteine methyltransferase EC=2.1.1.13 Length = 1148 Score = 1602 bits (4148), Expect = 0.0, Method: Compositional matrix adjust. Identities = 771/1139 (67%), Positives = 907/1139 (79%) Query: 3 KFTLAESLQQRILILDGAMGTMIQQVPLTGADFGGEELDGCNEMLVLTRPELIQGIHEKY 62 K T E L ++ILILDGAMGTM+QQ LT DFGGE DGCNE+L LTRP++I+ IHEKY Sbjct: 2 KPTFREQLSRKILILDGAMGTMLQQANLTADDFGGEAYDGCNELLNLTRPDVIRSIHEKY 61 Query: 63 LEAGADLIETNTFGATSVVLAEYDIPQRAREINLEAARLARNAVDKYDTPDRPRYVIGAM 122 LEAGAD++ETNTFGA S+VLAEYD+ ++ EIN+ AARLAR AVD Y T + PR+V GAM Sbjct: 62 LEAGADIVETNTFGAASIVLAEYDVAEKDLEINIAAARLAREAVDAYSTEEWPRFVAGAM 121 Query: 123 GPTTKTLSVTGGVTFQELVQSYEEQAAALIDGKVDALLLETSQDTLNVKAGSIGIRNAFE 182 GPTTKTLS+TGGVTF+ELV++Y QA LI G D LLLETSQDTLNVKAG IGIR AFE Sbjct: 122 GPTTKTLSLTGGVTFEELVEAYYRQAKGLILGGSDVLLLETSQDTLNVKAGGIGIRKAFE 181 Query: 183 RSGITLPVMISGTIEPMGTTLAGQNIEAFYISLEHLKPISIGLNCATGPEFMRDHIRSLS 242 G +PVM+SGTIEPMGTTLAGQNIEAFYISLEH+KP+SIGLNCATGPEFMRDH+R+LS Sbjct: 182 ELGQEIPVMLSGTIEPMGTTLAGQNIEAFYISLEHIKPVSIGLNCATGPEFMRDHLRTLS 241 Query: 243 AISSAAVSCYPNAGLPDENGNYHESPDSLARKLAGFAEKGWLNIAGGCCGTTPDHIRAMA 302 I+ AVSCYPNAGLPDENG+YHE+P LA K+ FAE+GW+N+AGGCCGTTPDHI+AMA Sbjct: 242 GIAQCAVSCYPNAGLPDENGHYHETPQGLASKMRAFAEQGWINVAGGCCGTTPDHIQAMA 301 Query: 303 EVLAEYPPRGLDGQHPPALSGIEPVYIESDNRPYMVGERTNVLGSRKFKRLIVEGKYEEA 362 E L + PR + A+SGIE VY+E DNRP +VGERTNV+GS+KF+ +I G YEEA Sbjct: 302 ETLKDCKPRSTAVEPLSAVSGIEVVYVEDDNRPLLVGERTNVIGSKKFREMIAAGHYEEA 361 Query: 363 SEIARAQVKNGAQVIDVCVQDPDRDESADITKFLELXXXXXXXPLMIDTTDPKVIDLALQ 422 S+IARAQVK GA VID+C+ DPDRDE D+ KFL+ PLMID+TD KV++L L+ Sbjct: 362 SDIARAQVKRGAHVIDICLADPDRDEYEDMEKFLQFIVKKVKAPLMIDSTDAKVMELGLR 421 Query: 423 YSQGKAIINSINLEDGEEKFELVTPLIHKYGAAIVVGTIDESGQAIKAADKLNVAKRSYE 482 YSQGKAI+NSINLEDG E+FE V PLIHK+GA++VVGTI+E+G AI KL VA+RSY+ Sbjct: 422 YSQGKAILNSINLEDGLERFEEVVPLIHKFGASVVVGTIEEAGMAITREKKLEVAQRSYD 481 Query: 483 LLVNKYGLAPEDLIFDTLVFPVGTGDEQYIGSAKETIDGIRLIKEALPEVHTILGISNVS 542 +LVN+YG+ P+D+IFD LVFPVGTGDEQYIGSAKET++GIRLIK+A+P TILG+SNVS Sbjct: 482 ILVNQYGIKPQDIIFDPLVFPVGTGDEQYIGSAKETVEGIRLIKQAMPACKTILGVSNVS 541 Query: 543 FGLPEAGREVLNSVFLYECTKAGLDYAIVNTEKVERYASIPEQERYLAEQLIYNTNDDTL 602 FGLP AGREVLN+VFLY T AGLDYAIVNTEK+ERYASIPE ER LAE L++ TND+TL Sbjct: 542 FGLPPAGREVLNAVFLYHTTLAGLDYAIVNTEKLERYASIPEDERKLAEALLFETNDETL 601 Query: 603 SAFVAAFRGKKVEKKEKISNLSLEERLASYVVEGTKEGLIPDLNEALTKSGPLEIINGPL 662 +AF +R KK E ++S+L+LEERLA YVVEG+K+GL+ DL AL K PLEIINGPL Sbjct: 602 AAFTEFYRQKKKEVSVEVSSLTLEERLARYVVEGSKDGLVEDLKLALDKYAPLEIINGPL 661 Query: 663 MAGMSEVGRLFNNNELIVAEVLQSAEVMKASVSHLEQFMQKDETSVKGKIMLATVKGDVH 722 M GM EVGRLFN N+LIVAEVLQSAEVMKASVS LE FM+K + + KGKI+LATVKGDVH Sbjct: 662 MTGMEEVGRLFNGNQLIVAEVLQSAEVMKASVSFLEPFMEKSDAAAKGKILLATVKGDVH 721 Query: 723 DIGKNLVEIILSNNGYEIINLGIKVPPESIIEAFRREKADAIGLSGLLVKSAQQMVLTAQ 782 DIGKNLVEIILSNNGY ++NLGIKVPPE +I A R EK DAIGLSGLLVKSAQQMV+TAQ Sbjct: 722 DIGKNLVEIILSNNGYNVVNLGIKVPPEQLIAACREEKPDAIGLSGLLVKSAQQMVITAQ 781 Query: 783 DLRTAGIDVPIMVGGAALTRKFTKTRIRPEYDGLVLYAKDAMDGLDIANRLMNPEERVKI 842 DLR AGID+P+MVGGAALTRKFT RI PEY G+VLYAKDAMDGLD+ NRL NPEER ++ Sbjct: 782 DLRDAGIDIPMMVGGAALTRKFTSNRIAPEYRGIVLYAKDAMDGLDLVNRLQNPEERDRL 841 Query: 843 XXXXXXXXXXXXXXXXXXXXXXLTRAVRSKISPDAPVFTPPDLERHVLRNYPLGHIIPYV 902 RS IS P+ PPD ERHVLR YPL H+ PY+ Sbjct: 842 VEEQQHLLEAVATAQPVVEEKKAPLPARSAISRTVPIHLPPDCERHVLRQYPLSHLQPYL 901 Query: 903 NMQMLLGHHLGLKGSVEAQLAAGDPRTVELKETVDEILHHAMLEGTMTPHAMYQFFPAQS 962 N++MLLG HLG++G+V+ + GD + +EL V+E+L A +GT+T H +YQFFPAQS Sbjct: 902 NLRMLLGKHLGVRGNVDRLIEEGDEKVLELYGIVEELLKEAKQKGTITTHGVYQFFPAQS 961 Query: 963 KGNDILIYDPQDTATVLHTFTFPRQNVEPYLCLADFLKSVDSGIMDYVGFLVVTAGHGIR 1022 GNDIL+YDP+D + +L F+FPRQ EP+LCL+DFL+ V+S MDYVGFL VTAG GIR Sbjct: 962 DGNDILVYDPKDHSKLLERFSFPRQLEEPHLCLSDFLRPVESKEMDYVGFLTVTAGGGIR 1021 Query: 1023 EMSAELRDKGDYLRSHXXXXXXXXXXXXXXXXXHHMMRDTWGFPDPADMTMKQRHGARYQ 1082 E S EL+D+GDYLRSH HH+MRD WG PDP +MTM +R GARYQ Sbjct: 1022 EKSTELKDRGDYLRSHVLQSLALELAEAFAERIHHVMRDVWGIPDPVEMTMLERFGARYQ 1081 Query: 1083 GIRVSFGYPACPDLEDQGPLFKLMSPGDIGVELTEGFMMEPEASVSAMVFAHPEAQYFN 1141 GIRVSFGYPACP+LEDQ LF+L+ P DIGV+LTEGFMMEPEASVSAMVFAHPEA+YFN Sbjct: 1082 GIRVSFGYPACPNLEDQAQLFRLLRPEDIGVQLTEGFMMEPEASVSAMVFAHPEARYFN 1140 >C1PC51.1 C1PC51_BACCO Methionine synthase Length = 1154 Score = 1501 bits (3887), Expect = 0.0, Method: Compositional matrix adjust. Identities = 729/1147 (63%), Positives = 878/1147 (76%), Gaps = 12/1147 (1%) Query: 8 ESLQQRILILDGAMGTMIQQVPLTGADFGGEELDGCNEMLVLTRPELIQGIHEKYLEAGA 67 + L RILILDGAMGTMIQQ LT ADFGGE +GCNE L LT P+LI+ IHE YLEAGA Sbjct: 8 QQLANRILILDGAMGTMIQQQHLTAADFGGEAYEGCNEYLNLTAPDLIRSIHEAYLEAGA 67 Query: 68 DLIETNTFGATSVVLAEYDIPQRAREINLEAARLARNAVDKYDTPDRPRYVIGAMGPTTK 127 D+IETNTFGATS+VL EY + A +IN+EAAR+A+ A K+ TP+RPR+V G+MGPTTK Sbjct: 68 DIIETNTFGATSIVLNEYGLGHFAEKINIEAARIAKQAAKKFSTPERPRFVAGSMGPTTK 127 Query: 128 TLSVTGGVTFQELVQSYEEQAAALIDGKVDALLLETSQDTLNVKAGSIGIRNAFERSGIT 187 TLSVTGG TF L +Y+EQA LI G VD LLLETSQD LNVKA +GI +AF +G Sbjct: 128 TLSVTGGTTFDALKTAYQEQACGLIKGGVDVLLLETSQDLLNVKAAFLGITDAFNETGKK 187 Query: 188 LPVMISGTIEPMGTTLAGQNIEAFYISLEHLKPISIGLNCATGPEFMRDHIRSLSAISSA 247 LP++ISGTIEPMGTTLAGQNIEAFYIS+EH++P ++GLNCATGPEFM D IR+L+ ++ Sbjct: 188 LPLLISGTIEPMGTTLAGQNIEAFYISVEHMQPAAVGLNCATGPEFMADSIRTLAGLAKT 247 Query: 248 AVSCYPNAGLPDENGNYHESPDSLARKLAGFAEKGWLNIAGGCCGTTPDHIRAMAEVLAE 307 AVSCYPNAGLPDE G+YHE+P+SLA K+ GFAEKGWLNIAGGCCGTTP HI+A+ E LA Sbjct: 248 AVSCYPNAGLPDEEGHYHETPESLAVKMKGFAEKGWLNIAGGCCGTTPAHIKALNEALAG 307 Query: 308 YPPRGLDGQHPPALSGIEP-VYIESDNRPYMVGERTNVLGSRKFKRLIVEGKYEEASEIA 366 PPR Q A+SGIEP +Y + RP VGERTNV+GSRKF+RLI EGK+EEASEIA Sbjct: 308 LPPRQPAKQEHHAVSGIEPFIYDDPSTRPIFVGERTNVIGSRKFRRLIAEGKWEEASEIA 367 Query: 367 RAQVKNGAQVIDVCVQDPDRDESADITKFLELXXXXXXXPLMIDTTDPKVIDLALQYSQG 426 R QVKNGAQ+ID+C+ DPDRDE +D+ F+ + P MID+TD VI+ A Y QG Sbjct: 368 RTQVKNGAQIIDICLADPDRDEISDMENFISIAVKKVKVPFMIDSTDENVIEKAFTYCQG 427 Query: 427 KAIINSINLEDGEEKFELVTPLIHKYGAAIVVGTIDESGQAIKAADKLNVAKRSYELLVN 486 K+I+NSINLE+G E+FE V PL+ KYG A+VVGTIDE G A+ A KL +A+RSY+LLV+ Sbjct: 428 KSIVNSINLENGTERFEKVVPLLKKYGGAVVVGTIDEEGMAVTAERKLEIARRSYDLLVD 487 Query: 487 KYGLAPEDLIFDTLVFPVGTGDEQYIGSAKETIDGIRLIKEALPEVHTILGISNVSFGLP 546 YGL P DLIFD LVFP GTGD+QY G+AKET++GIRLIKEA+PE TILG+SNVSFGLP Sbjct: 488 TYGLNPRDLIFDPLVFPAGTGDKQYFGAAKETVEGIRLIKEAMPECQTILGVSNVSFGLP 547 Query: 547 EAGREVLNSVFLYECTKAGLDYAIVNTEKVERYASIPEQERYLAEQLIYNTNDDTLSAFV 606 AGREVLNSVFLY CTKAGLDYAIVNTEK+ER+ASIPE+ +AE+L++ T+D+ L+AF Sbjct: 548 PAGREVLNSVFLYHCTKAGLDYAIVNTEKLERFASIPEENVKMAEKLLFETSDEALAAFT 607 Query: 607 AAFRGKKVEKKEKISNLSLEERLASYVVEGTKEGLIPDLNEALTK-SGPLEIINGPLMAG 665 +RGK EKK S ++L ERLA+YVVEGTKEGLIPDL +AL + PL IINGPLM G Sbjct: 608 EYYRGKVQEKKAPKSTMTLAERLANYVVEGTKEGLIPDLEQALKEYPDPLAIINGPLMDG 667 Query: 666 MSEVGRLFNNNELIVAEVLQSAEVMKASVSHLEQFMQKDETSVKGKIMLATVKGDVHDIG 725 M+EVGRLFN+N+LIVAEVLQSAEVMKASV+ LE FM+K+ETS KGK++LATVKGDVHDIG Sbjct: 668 MAEVGRLFNDNQLIVAEVLQSAEVMKASVAFLEPFMEKNETSTKGKVLLATVKGDVHDIG 727 Query: 726 KNLVEIILSNNGYEIINLGIKVPPESIIEAFRREKADAIGLSGLLVKSAQQMVLTAQDLR 785 KNLV+IILSNNGY++++LGIKV P +I A R+EK D IGLSGLLVKSAQQMV+TAQDLR Sbjct: 728 KNLVDIILSNNGYKVVDLGIKVAPADLIHAVRKEKPDVIGLSGLLVKSAQQMVVTAQDLR 787 Query: 786 TAGIDVPIMVGGAALTRKFTKTRIRPEYDGLVLYAKDAMDGLDIANRLMNPEERVKIXXX 845 AGI PI+VGGAAL+RKFT +I P+Y+GLVLYAKDAM+GL +AN+L + ER + Sbjct: 788 EAGIRQPILVGGAALSRKFTVNKIAPQYEGLVLYAKDAMEGLTLANKLQDESERSSLETE 847 Query: 846 XXXXXX--XXXXXXXXXXXXXLTRAVRSKISPDAPVFTPPDLERHVLRNYPLGHIIPYVN 903 T RS +SPDA V+ P DL+RHVLRNYPL HI PYVN Sbjct: 848 LANQRSGGTRVAAVNAGGAPVATLPRRSSVSPDALVYQPADLKRHVLRNYPLAHIEPYVN 907 Query: 904 MQMLLGHHLGLKGSVEAQLAAGDPRTVELKETVDEILHHAMLEGTMTPHAMYQFFPAQSK 963 MQMLLGHHLGLKG VE LA GD R ++LK+ VDE+ M E + P A+YQFFPAQS Sbjct: 908 MQMLLGHHLGLKGRVEKLLAEGDERALKLKQQVDELREWVMKEKLLQPSAVYQFFPAQSD 967 Query: 964 GNDILIYDPQ--------DTATVLHTFTFPRQNVEPYLCLADFLKSVDSGIMDYVGFLVV 1015 GN +++Y+P + +VL FTFPRQ PYLCLAD+++SVDSG++DYV V Sbjct: 968 GNTLIVYEPAGEPGTLDLKSLSVLERFTFPRQAKPPYLCLADYVRSVDSGVVDYVCMFAV 1027 Query: 1016 TAGHGIREMSAELRDKGDYLRSHXXXXXXXXXXXXXXXXXHHMMRDTWGFPDPADMTMKQ 1075 AG IR + L++ G+Y +SH H ++R WGFPDPAD TM+Q Sbjct: 1028 VAGKNIRHHARYLKEAGEYFKSHALQALALETAEGFAERLHELIRGQWGFPDPADFTMQQ 1087 Query: 1076 RHGARYQGIRVSFGYPACPDLEDQGPLFKLMSPGDIGVELTEGFMMEPEASVSAMVFAHP 1135 R A+YQG R SFGYPACP+LEDQ LFKL+ P IG+ LTEG+MMEPEA+V+A+VF+HP Sbjct: 1088 RFAAKYQGQRYSFGYPACPNLEDQAKLFKLLQPQKIGLHLTEGYMMEPEAAVTALVFSHP 1147 Query: 1136 EAQYFNV 1142 EA+YF V Sbjct: 1148 EARYFAV 1154 >Q9KCE1.1 Q9KCE1_BACHD 5-methyltetrahydrofolate S-homocysteine methyltransferase EC=2.1.1.13 Length = 1146 Score = 1496 bits (3872), Expect = 0.0, Method: Compositional matrix adjust. Identities = 734/1146 (64%), Positives = 881/1146 (76%), Gaps = 5/1146 (0%) Query: 1 VAKFTLAESLQQRILILDGAMGTMIQQVPLTGADFGGEELDGCNEMLVLTRPELIQGIHE 60 + K + L+++I+ILDGAMGTM+Q LT DFGGEE +GCNE L T P +++ IH Sbjct: 1 MTKSLFEQQLERKIVILDGAMGTMLQAANLTADDFGGEEYEGCNEYLNETAPHVVEDIHR 60 Query: 61 KYLEAGADLIETNTFGATSVVLAEYDIPQRAREINLEAARLARNAVDKYDTPDRPRYVIG 120 YLEAGAD+I TNTFGAT +VL +YD+ +A E+N+ A ++A+ +++ TPD PR+V G Sbjct: 61 AYLEAGADVIATNTFGATDIVLDDYDLGYKAEELNICAVKIAKRVAEEFSTPDWPRFVAG 120 Query: 121 AMGPTTKTLSVTGGVTFQELVQSYEEQAAALIDGKVDALLLETSQDTLNVKAGSIGIRNA 180 AMGPTTK+LSVTGG TF++L++SY +QA LI G D LLLETSQD NVKA +G+ A Sbjct: 121 AMGPTTKSLSVTGGATFEQLIESYRQQATGLIKGGADILLLETSQDMRNVKAAYLGLSQA 180 Query: 181 FERSGITLPVMISGTIEPMGTTLAGQNIEAFYISLEHLKPISIGLNCATGPEFMRDHIRS 240 + + LP++ISGTIEPMGTTLAGQNIEAFY+SLEH+ P+ +GLNCATGPEFMRDH+RS Sbjct: 181 QKELEVKLPLIISGTIEPMGTTLAGQNIEAFYLSLEHMNPVVVGLNCATGPEFMRDHLRS 240 Query: 241 LSAISSAAVSCYPNAGLPDENGNYHESPDSLARKLAGFAEKGWLNIAGGCCGTTPDHIRA 300 LS +++ +VSCYPNAGLPDE GNYHESP+SLA KLAGFAEKGWLN+ GGCCGTTPDHIRA Sbjct: 241 LSDLATCSVSCYPNAGLPDEEGNYHESPESLAAKLAGFAEKGWLNMVGGCCGTTPDHIRA 300 Query: 301 MAEVLAEYPPRGLDGQHPPALSGIEPVYIESDNRPYMVGERTNVLGSRKFKRLIVEGKYE 360 + +V+ ++ PR G HP ++SGIEP+ + RP VGERTNV+GSRKFKRLI E KYE Sbjct: 301 LLDVMKQFEPRQPKGDHPHSVSGIEPLLYDDSMRPLFVGERTNVIGSRKFKRLIEEEKYE 360 Query: 361 EASEIARAQVKNGAQVIDVCVQDPDRDESADITKFLELXXXXXXXPLMIDTTDPKVIDLA 420 EASEIAR+QVK GA VIDVC+ DPDRDE D+ +FL+ PLMID+TD KVI+ A Sbjct: 361 EASEIARSQVKKGAHVIDVCLADPDRDEMEDMEEFLKFVINKVKVPLMIDSTDEKVIEQA 420 Query: 421 LQYSQGKAIINSINLEDGEEKFELVTPLIHKYGAAIVVGTIDESGQAIKAADKLNVAKRS 480 L YSQGKAIINSINLEDGEE+FE V PL+HKYGAA+VVGTIDE G AI A KL VAKRS Sbjct: 421 LTYSQGKAIINSINLEDGEERFEKVVPLVHKYGAAVVVGTIDEEGMAITAEKKLAVAKRS 480 Query: 481 YELLVNKYGLAPEDLIFDTLVFPVGTGDEQYIGSAKETIDGIRLIKEALPEVHTILGISN 540 Y+LLVNKY + P D+IFD LVFPVGTGDEQYIGSA ET++GIR IKE LPE TILG+SN Sbjct: 481 YDLLVNKYNIRPSDIIFDPLVFPVGTGDEQYIGSANETVEGIRRIKEELPECLTILGVSN 540 Query: 541 VSFGLPEAGREVLNSVFLYECTKAGLDYAIVNTEKVERYASIPEQERYLAEQLIYNTNDD 600 VSFGLP GREVLN+ +LY CT+AGLDYAIVNTEK+ERYASI ++E+ L+ +L++ T D+ Sbjct: 541 VSFGLPPVGREVLNAAYLYHCTQAGLDYAIVNTEKLERYASISDEEKELSRKLLFETTDE 600 Query: 601 TLSAFVAAFRGKKVEKKEKISNLSLEERLASYVVEGTKEGLIPDLNEALTK-SGPLEIIN 659 TL+ F A +RGKK EKK + SNL+LEERLA+Y+VEG+K+GL DL++AL K PL+IIN Sbjct: 601 TLAEFTAFYRGKKAEKKVETSNLTLEERLANYIVEGSKDGLTEDLDKALAKYDDPLDIIN 660 Query: 660 GPLMAGMSEVGRLFNNNELIVAEVLQSAEVMKASVSHLEQFMQKD-ETSVKGKIMLATVK 718 GPLM GM EVGRLFNNNELIVAEVLQSAEVMKASV+HLE M+K + KGKI+LATVK Sbjct: 661 GPLMNGMDEVGRLFNNNELIVAEVLQSAEVMKASVAHLEPHMEKKADDHGKGKIILATVK 720 Query: 719 GDVHDIGKNLVEIILSNNGYEIINLGIKVPPESIIEAFRREKADAIGLSGLLVKSAQQMV 778 GDVHDIGKNLVEIILSNNG+ I+NLGIKV +IEA RE DAIGLSGLLVKSAQQMV Sbjct: 721 GDVHDIGKNLVEIILSNNGFRIVNLGIKVTSNELIEAVARENPDAIGLSGLLVKSAQQMV 780 Query: 779 LTAQDLRTAGIDVPIMVGGAALTRKFTKTRIRPEYDGLVLYAKDAMDGLDIANRLMNPEE 838 LTAQDL+ I +PI+VGGAALTRKFT T+I PEYDGLV+YAKDAM+GL++AN+LM P+E Sbjct: 781 LTAQDLKQQQISIPILVGGAALTRKFTNTKIAPEYDGLVVYAKDAMNGLELANKLMKPDE 840 Query: 839 RVKIXXXXXXXXXXXXXXXXX--XXXXXLTRAVRSKISPDAPVFTPPDLERHVLRNYPLG 896 R K+ + RS +S PV PPD++ H+LR++ + Sbjct: 841 REKLAVSLHEAKEQANSRTQMGGGGTAVAVKPTRSHVSTTVPVAVPPDVKPHILRHHSIA 900 Query: 897 HIIPYVNMQMLLGHHLGLKGSVEAQLAAGDPRTVELKETVDEILHHAMLEGTMTPHAMYQ 956 H+ PY+NMQMLLG HLGL+G V LA D + +ELKE VD +L E M H MYQ Sbjct: 901 HLEPYINMQMLLGRHLGLQGKVSRLLAEKDEKALELKEKVDALLTRVKEEQLMEAHGMYQ 960 Query: 957 FFPAQSKGNDILIYDPQDTATVLHTFTFPRQNVEPYLCLADFLKSVDSGIMDYVGFLVVT 1016 FFPAQS G+DI+IYD Q + F FPRQN EPYLCLADFL+ V SG MDYVGFL VT Sbjct: 961 FFPAQSDGDDIVIYD-QTGTNEIERFHFPRQNKEPYLCLADFLRPVSSGEMDYVGFLAVT 1019 Query: 1017 AGHGIREMSAELRDKGDYLRSHXXXXXXXXXXXXXXXXXHHMMRDTWGFPDPADMTMKQR 1076 AG GIRE+ + ++ GDYL SH H +MRD WGFPD AD TM++R Sbjct: 1020 AGKGIRELGEQAKEAGDYLFSHLIQATALEMAEGFAERVHQLMRDKWGFPDSADFTMEER 1079 Query: 1077 HGARYQGIRVSFGYPACPDLEDQGPLFKLMSPGDIGVELTEGFMMEPEASVSAMVFAHPE 1136 A+Y+GIRVSFGYPACPDL+DQ LFKL+ PG IG+ELTEGFMMEPEASV+AMVFAHPE Sbjct: 1080 FAAKYRGIRVSFGYPACPDLDDQAKLFKLLKPGKIGIELTEGFMMEPEASVTAMVFAHPE 1139 Query: 1137 AQYFNV 1142 A+YFNV Sbjct: 1140 ARYFNV 1145 >Q2BAQ5.1 Q2BAQ5_9BACI 5-methyltetrahydrofolate--homocysteine S-methyltransferase Length = 1149 Score = 1492 bits (3863), Expect = 0.0, Method: Compositional matrix adjust. Identities = 720/1147 (62%), Positives = 883/1147 (76%), Gaps = 4/1147 (0%) Query: 3 KFTLAESLQQRILILDGAMGTMIQQVPLTGADFGGEELDGCNEMLVLTRPELIQGIHEKY 62 K +L+E + +ILI+DGAMGTM+Q+ L+ DFGGE+ DGCNE L LT P +I+ IH Y Sbjct: 3 KISLSERMNNKILIMDGAMGTMLQRADLSAEDFGGEQYDGCNEYLNLTAPGVIKEIHLAY 62 Query: 63 LEAGADLIETNTFGATSVVLAEYDIPQRAREINLEAARLARNAVDKYDTPDRPRYVIGAM 122 L+AGAD+IETNTFGATS+VL EY + ++A EIN A+ +AR A D+ TP PR+V G+M Sbjct: 63 LKAGADIIETNTFGATSIVLDEYSLKEKAYEINRTASLIARKAADQISTPSWPRFVAGSM 122 Query: 123 GPTTKTLSVTGGVTFQELVQSYEEQAAALIDGKVDALLLETSQDTLNVKAGSIGIRNAFE 182 GPTTKTLSVTGG TF+EL SYEEQA LIDGK D LLLETSQD LNVKAG IGI+NAF+ Sbjct: 123 GPTTKTLSVTGGTTFEELSLSYEEQACGLIDGKADLLLLETSQDMLNVKAGYIGIQNAFK 182 Query: 183 RSGITLPVMISGTIEPMGTTLAGQNIEAFYISLEHLKPISIGLNCATGPEFMRDHIRSLS 242 ++GITLP+++SGTIEPMGTTLAGQ IEAFYISLEH+KP+++GLNCATGPEFM++HIRSLS Sbjct: 183 KTGITLPLIVSGTIEPMGTTLAGQPIEAFYISLEHMKPLAVGLNCATGPEFMQEHIRSLS 242 Query: 243 AISSAAVSCYPNAGLPDENGNYHESPDSLARKLAGFAEKGWLNIAGGCCGTTPDHIRAMA 302 +++ AAVSCYPNAGLPDE G YHE+P+SLA KLAGFA +GWLNI GGCCGTTP+HI+A+A Sbjct: 243 SLADAAVSCYPNAGLPDEEGRYHETPESLAEKLAGFASQGWLNIVGGCCGTTPEHIKAIA 302 Query: 303 EVLAEYPPRGLDGQHPPALSGIEP-VYIESDNRPYMVGERTNVLGSRKFKRLIVEGKYEE 361 + + + PR + +SGIEP +Y + RP MVGERTNV+GSRKF+RLI EGK+EE Sbjct: 303 DKMEHFAPRKISAASAHKVSGIEPLIYDDPTLRPIMVGERTNVIGSRKFRRLIAEGKFEE 362 Query: 362 ASEIARAQVKNGAQVIDVCVQDPDRDESADITKFLELXXXXXXXPLMIDTTDPKVIDLAL 421 ASE+ARAQVKNGA VID+C+ DPDRDE D+ F++ P++ID+TD KVI+ AL Sbjct: 363 ASEVARAQVKNGAHVIDICLADPDRDELEDMENFIKEVTKKVKAPIVIDSTDEKVIEKAL 422 Query: 422 QYSQGKAIINSINLEDGEEKFELVTPLIHKYGAAIVVGTIDESGQAIKAADKLNVAKRSY 481 Y QGK++INSINLEDGEE+FE + PLI YGAA+VVGTIDE G + A KL +A RSY Sbjct: 423 IYLQGKSVINSINLEDGEERFEAIAPLIRLYGAAVVVGTIDEKGMGVSADRKLEIASRSY 482 Query: 482 ELLVNKYGLAPEDLIFDTLVFPVGTGDEQYIGSAKETIDGIRLIKEALPEVHTILGISNV 541 LLV KYG+ PED+IFD LVFPVGTGDEQYIGSA+ T++GIRLIKE P+ TILGISNV Sbjct: 483 TLLVEKYGIPPEDIIFDPLVFPVGTGDEQYIGSAEATVEGIRLIKERFPKTQTILGISNV 542 Query: 542 SFGLPEAGREVLNSVFLYECTKAGLDYAIVNTEKVERYASIPEQERYLAEQLIYNTNDDT 601 SFGLP GRE+LNSVFLY CT+AGLDYAIVNTEK+ER+ASI +E LAE+L++ T D+T Sbjct: 543 SFGLPPVGREILNSVFLYHCTQAGLDYAIVNTEKLERFASIASEEIALAEKLLFETTDET 602 Query: 602 LSAFVAAFRGKKVEKKEKISNLSLEERLASYVVEGTKEGLIPDLNEALTK-SGPLEIING 660 L+ F +RGKK E+K + ++SL ERLA Y+ EGTKEGL+ DL AL + S PLEIING Sbjct: 603 LAQFTEFYRGKKKEEKSLLPDMSLAERLAYYIKEGTKEGLLEDLKAALLEYSSPLEIING 662 Query: 661 PLMAGMSEVGRLFNNNELIVAEVLQSAEVMKASVSHLEQFMQKDETSVKGKIMLATVKGD 720 PLM GM EVGRLFN+N+LIVAEVLQSAEVMKASVS+LE FM+K +S KGKI+LATVKGD Sbjct: 663 PLMDGMKEVGRLFNDNQLIVAEVLQSAEVMKASVSYLEPFMEKGTSSGKGKIILATVKGD 722 Query: 721 VHDIGKNLVEIILSNNGYEIINLGIKVPPESIIEAFRREKADAIGLSGLLVKSAQQMVLT 780 VHDIGKNLV+IILSNNGYE+I+LGIKV P ++EA ++EK + +GLSGLLVKSAQQMV+T Sbjct: 723 VHDIGKNLVDIILSNNGYEVIDLGIKVSPSELVEAVKKEKPNMVGLSGLLVKSAQQMVIT 782 Query: 781 AQDLRTAGIDVPIMVGGAALTRKFTKTRIRPEYDGLVLYAKDAMDGLDIANRLMNPEERV 840 A D++ AGID+PI+VGGAAL+RKFT T+I EY+GLV+YAKDAM+GL IA++L + E Sbjct: 783 ASDMKQAGIDIPILVGGAALSRKFTDTKISREYNGLVMYAKDAMNGLSIADQLRDEPEYN 842 Query: 841 KIXXXXXXXXXXXXXXXXXXXXXXLTRA--VRSKISPDAPVFTPPDLERHVLRNYPLGHI 898 ++ A VR + D PVF P DLERHVLR+Y LGHI Sbjct: 843 RLLAEQEAKRSLPLPSALTERKTGALAALKVRPSVRSDVPVFVPQDLERHVLRSYTLGHI 902 Query: 899 IPYVNMQMLLGHHLGLKGSVEAQLAAGDPRTVELKETVDEILHHAMLEGTMTPHAMYQFF 958 PY+N QMLLGHHLGLKG++ + +GD + ++L +TVD ++ A EG + P A+YQFF Sbjct: 903 EPYINRQMLLGHHLGLKGNISRLIESGDEKALKLNDTVDSLIVQAKTEGWIIPSAVYQFF 962 Query: 959 PAQSKGNDILIYDPQDTATVLHTFTFPRQNVEPYLCLADFLKSVDSGIMDYVGFLVVTAG 1018 PAQS GN ++IYD D + +L F FPRQ EP+LCLAD+LK G MDYV F VTAG Sbjct: 963 PAQSDGNKVIIYDKDDHSRILEVFDFPRQQTEPFLCLADYLKPAGGGEMDYVAFFSVTAG 1022 Query: 1019 HGIREMSAELRDKGDYLRSHXXXXXXXXXXXXXXXXXHHMMRDTWGFPDPADMTMKQRHG 1078 + +RE + L+ +G +L +H H +RD WGFPDP D TMK+R Sbjct: 1023 NAVRETAEILKKEGRFLENHALQALALETAEGFAELVHRQIRDRWGFPDPVDFTMKERFS 1082 Query: 1079 ARYQGIRVSFGYPACPDLEDQGPLFKLMSPGDIGVELTEGFMMEPEASVSAMVFAHPEAQ 1138 A+YQG R SFGYPACP+LEDQ LF L+ P +IG++LTEGFMMEPEASVSAMVFAHPEA+ Sbjct: 1083 AKYQGQRFSFGYPACPELEDQRKLFDLIKPEEIGIDLTEGFMMEPEASVSAMVFAHPEAR 1142 Query: 1139 YFNVEKQ 1145 YFNV K Sbjct: 1143 YFNVLKN 1149 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.317 0.136 0.386 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 6,447,916,883 Number of extensions: 270197336 Number of successful extensions: 720006 Number of sequences better than 1.0e-05: 2087 Number of HSP's gapped: 707785 Number of HSP's successfully gapped: 2689 Length of query: 1145 Length of database: 3,060,696,203 Length adjustment: 147 Effective length of query: 998 Effective length of database: 1,675,806,998 Effective search space: 1672455384004 Effective search space used: 1672455384004 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 137 (57.4 bits)