BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0470.0004.p (609 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KFH1.1 B3KFH1_9BACI Histidine kinase internal region 984 0.0 B1D8F0.1 B1D8F0_9BACL Signal transduction histidine kinase, LytS 942 0.0 A4XMH3.1 A4XMH3_CALS8 Integral membrane sensor signal transducti... 278 2e-72 B1DAL8.1 B1DAL8_9BACL Signal transduction histidine kinase, LytS 220 3e-55 B1DGK6.1 B1DGK6_9BACL Histidine kinase internal region 197 3e-48 >B3KFH1.1 B3KFH1_9BACI Histidine kinase internal region Length = 609 Score = 984 bits (2544), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/609 (79%), Positives = 535/609 (87%) Query: 1 MKTSKLKLKHQIWLIFFFSIVIFTVMEFYFFYSFSNLTQKRAATYGNQMIEQTRRKIDSV 60 MK SKLKLKHQIWLIFFFSI+IFTVMEFY++YSFSNLTQKRAA Y NQMIEQTRRKIDS Sbjct: 1 MKISKLKLKHQIWLIFFFSIIIFTVMEFYYYYSFSNLTQKRAAHYSNQMIEQTRRKIDSA 60 Query: 61 FNDIRVSTSIAVNSKLIQEFSVVDDDYKRAFDSGPYALDLMEYMRSFNSYVSGIVINDIR 120 F+DIRVSTSIAVNS+ +QEFSVVDDDYKRAF+SGP ALDLMEYMRSFNSYV+GIVINDI+ Sbjct: 61 FSDIRVSTSIAVNSRRVQEFSVVDDDYKRAFNSGPNALDLMEYMRSFNSYVNGIVINDIQ 120 Query: 121 GRRLYSLESASGDIFYINRYEAFIRKYKDDPSLREKGMFTTILKDDRTDTEQFFYIAPIV 180 GRRLYSL SASGDIF++NRY+ FI+KYK+DPSLR+KGMFT+ILKDDRT TEQFFYIAPIV Sbjct: 121 GRRLYSLASASGDIFFLNRYDTFIQKYKEDPSLRDKGMFTSILKDDRTGTEQFFYIAPIV 180 Query: 181 ETIGGIHFSQITGYCTVMVNMEKMQGLVKNTELTQSSTLYILNNRDEVIASTNSNARGTL 240 E IGGI+FSQITGYCTV+VNM+KMQGLV+NTELT +STLYILN+RDEVIASTNSNARG L Sbjct: 181 EAIGGIYFSQITGYCTVLVNMDKMQGLVENTELTPNSTLYILNSRDEVIASTNSNARGAL 240 Query: 241 FRDVLSMDKDILLNGVKANIDGEDILVQVKGLEQADGWRVVSMIPVHELTADMAPMRKVS 300 FRDVLSMDK +LL GVK IDGEDILVQVKGLEQADGWR+VSMIPV ELTADM P+RKVS Sbjct: 241 FRDVLSMDKGLLLKGVKTTIDGEDILVQVKGLEQADGWRLVSMIPVQELTADMNPIRKVS 300 Query: 301 XXXXXXXXXXXXXXXSFFMNNLMRPVMGLVMDMKRVGRRDMGFRIKVRFTNEVGLLACDI 360 SFFMNNLMRPVMGLV+DMKRVG RDM FRIKVR TNEVG+LACDI Sbjct: 301 IIVGIGMILSMLIMGSFFMNNLMRPVMGLVLDMKRVGSRDMDFRIKVRSTNEVGMLACDI 360 Query: 361 NXXXXXXXXXXXXXFNTQARLYESELSQKQAEFSALQSQINPHFLYNTLNCISSIGLEYG 420 N TQARLYESELSQKQAEF+ALQSQINPHFLYNTLNCISSIGLEYG Sbjct: 361 NRVINEREQMARDMIKTQARLYESELSQKQAEFAALQSQINPHFLYNTLNCISSIGLEYG 420 Query: 421 SREIAQITFCMSKIFRYSIKKDDLVQIWEEVDCIQAYMKIILIRYENKFSMELDVEDRLL 480 SREIAQI CMSKIFRYSI+KDDLV+I EE+DCIQAYM II IRYENKF +E+DV++ LL Sbjct: 421 SREIAQIASCMSKIFRYSIRKDDLVRIREELDCIQAYMNIIAIRYENKFIIEIDVDEGLL 480 Query: 481 KMKTPKMILQPIVENSVYHGLERMDQGGRLLVTGSIDVHGDVCFCITDTGRGMEPEELAA 540 +M+TPKMILQPIVEN+VYHGLERMDQGGRL VTGSID HGDVCF ITDTG+GM+PE+LA+ Sbjct: 481 EMQTPKMILQPIVENAVYHGLERMDQGGRLQVTGSIDAHGDVCFQITDTGKGMDPEQLAS 540 Query: 541 LQAKLGMEYREQASEGQPAKGIGLTNIHNRLRMLFGEGYGITIESRFGEGTTVTVKIPKL 600 LQAKLGM E A +GQPA IGL+NIHNRLR+LFGEGYGI IES+ G GTTVTV+I KL Sbjct: 541 LQAKLGMASPEPAPDGQPATSIGLSNIHNRLRLLFGEGYGIAIESQIGHGTTVTVRIQKL 600 Query: 601 LDDRKPLEE 609 L++RK EE Sbjct: 601 LNNRKHSEE 609 >B1D8F0.1 B1D8F0_9BACL Signal transduction histidine kinase, LytS Length = 601 Score = 942 bits (2434), Expect = 0.0, Method: Compositional matrix adjust. Identities = 464/600 (77%), Positives = 523/600 (87%) Query: 1 MKTSKLKLKHQIWLIFFFSIVIFTVMEFYFFYSFSNLTQKRAATYGNQMIEQTRRKIDSV 60 MKTS+LKLKHQIWLIFFF+IVIFTVM YFFYSFS+LTQ RAA +GNQMIEQTR KID+V Sbjct: 1 MKTSRLKLKHQIWLIFFFAIVIFTVMVLYFFYSFSHLTQSRAANFGNQMIEQTRSKIDTV 60 Query: 61 FNDIRVSTSIAVNSKLIQEFSVVDDDYKRAFDSGPYALDLMEYMRSFNSYVSGIVINDIR 120 FNDIRVST IAVNSKLIQE++VVDDDYKRAFDSG YALDLM+YMRSFNSYVSGIVI+D+R Sbjct: 61 FNDIRVSTGIAVNSKLIQEYAVVDDDYKRAFDSGNYALDLMDYMRSFNSYVSGIVIDDVR 120 Query: 121 GRRLYSLESASGDIFYINRYEAFIRKYKDDPSLREKGMFTTILKDDRTDTEQFFYIAPIV 180 G++LYSL+S+ GDIF+++RY +FI+ YK DPSLREKGMFTT LKDD ++EQFFYIAPIV Sbjct: 121 GKQLYSLDSSGGDIFFLHRYASFIQAYKKDPSLREKGMFTTTLKDDSMESEQFFYIAPIV 180 Query: 181 ETIGGIHFSQITGYCTVMVNMEKMQGLVKNTELTQSSTLYILNNRDEVIASTNSNARGTL 240 E+IGGI+FSQITGY TVMVNM+K+QGLV+NTELT STLYIL++++EVIASTN+ ARG+L Sbjct: 181 ESIGGIYFSQITGYFTVMVNMDKLQGLVENTELTPHSTLYILDSQEEVIASTNAKARGSL 240 Query: 241 FRDVLSMDKDILLNGVKANIDGEDILVQVKGLEQADGWRVVSMIPVHELTADMAPMRKVS 300 F+D+LSMDKD L +GVK IDGEDILVQVKGLEQADGWR+VSMIPVHELTADM PMRKVS Sbjct: 241 FKDLLSMDKDNLRDGVKTTIDGEDILVQVKGLEQADGWRIVSMIPVHELTADMNPMRKVS 300 Query: 301 XXXXXXXXXXXXXXXSFFMNNLMRPVMGLVMDMKRVGRRDMGFRIKVRFTNEVGLLACDI 360 FFMN+LM PVMGLVMDMKRVGRRD GFRIKVR TNEVG LA DI Sbjct: 301 IIVGIGIILILIMMGIFFMNSLMNPVMGLVMDMKRVGRRDRGFRIKVRSTNEVGSLARDI 360 Query: 361 NXXXXXXXXXXXXXFNTQARLYESELSQKQAEFSALQSQINPHFLYNTLNCISSIGLEYG 420 N FNTQARLY+SELSQKQAEFSALQSQINPHFLYNTLNCISSIGLEYG Sbjct: 361 NRMMDEMEEMTRDMFNTQARLYKSELSQKQAEFSALQSQINPHFLYNTLNCISSIGLEYG 420 Query: 421 SREIAQITFCMSKIFRYSIKKDDLVQIWEEVDCIQAYMKIILIRYENKFSMELDVEDRLL 480 SREIAQ+T MSKIFRYSIK+D+LVQI EE DCIQAY+KII IRY+NKF+M++D+E+ LL Sbjct: 421 SREIAQMTSSMSKIFRYSIKQDELVQIKEEADCIQAYIKIITIRYDNKFAMKMDIEEGLL 480 Query: 481 KMKTPKMILQPIVENSVYHGLERMDQGGRLLVTGSIDVHGDVCFCITDTGRGMEPEELAA 540 +M+TPKMILQPIVENSVYHGLERMDQGG+L VTGS+D GDV FCI DTG+GMEPEELAA Sbjct: 481 RMRTPKMILQPIVENSVYHGLERMDQGGQLEVTGSMDEQGDVYFCIRDTGKGMEPEELAA 540 Query: 541 LQAKLGMEYREQASEGQPAKGIGLTNIHNRLRMLFGEGYGITIESRFGEGTTVTVKIPKL 600 LQAKL +Y E+A +GQP++ IGLTNIHNRLR+LFGE YGITIESR G GTTVTVKIP L Sbjct: 541 LQAKLAADYPERAQDGQPSQSIGLTNIHNRLRLLFGESYGITIESRAGYGTTVTVKIPAL 600 >A4XMH3.1 A4XMH3_CALS8 Integral membrane sensor signal transduction histidine kinase Length = 617 Score = 278 bits (710), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 179/609 (29%), Positives = 315/609 (51%), Gaps = 34/609 (5%) Query: 17 FFSIVIFTVMEFYFFYSFSNLTQKRAATYGNQMIEQTRRKIDSVFNDIRVS-TSIAVNS- 74 F SI I ++ ++ F + +K Y I Q I + I S +IA N Sbjct: 22 FISITIVIFIQVIYYIRFQVIIRKYTNVYMQNSINQVEETIYTTLKTIYKSGLTIAYNKY 81 Query: 75 --------KLIQEFSVVDDDYKRAFDSGPYALDLMEYMRSFNSYVSGIVINDIRGRRLYS 126 L Q+ ++ Y+ + Y ++M Y+ + N + I + D R+++ Sbjct: 82 TQLFLIDKPLNQDIDTQEEYYQYRLELSRYLTEMMRYIINSNENIKDIALVD-PNERVFT 140 Query: 127 LESASGDIFYINRYEAFIRKY-KDDPSLREKGMFTT--ILKDDRTDTEQFFYIAPIVETI 183 +S I +N Y+ I K K L+ IL + T F I PI T+ Sbjct: 141 FQS----IISLNNYKHAINKLLKKTGHLKRYNWVHNDDILNTNNLKTYYFSLIIPIYSTL 196 Query: 184 GGIHFSQITGYCTVMVNMEKMQGLVKNTELTQSSTLYILNNRDEVIASTNSNARGTLFRD 243 + + G ++ N + + + + +T +S+ I + ++++S++S+ G +F Sbjct: 197 EELDNLEPLGTLVILCNTAVINQISQKSLITPNSSFIITDENGKIVSSSDSSLIGEIF-- 254 Query: 244 VLSMDKDILLNGVK------ANIDGEDILVQVKGLEQADGWRVVSMIPVHELTADMAPMR 297 +K+IL+ K + G+ L+Q K + + + W+++S+IP +ELT+++ + Sbjct: 255 ----NKNILVKLNKHSGIFISQYQGKKSLIQYKNISETN-WKLISIIPWNELTSNITQLT 309 Query: 298 KVSXXXXXXXXXXXXXXXSFFMNNLMRPVMGLVMDMKRVG-RRDMGFRIKVRFTNEVGLL 356 F+ N+ RPV ++ +K + ++ RI+V NE+GL+ Sbjct: 310 FFVFIIGVIMLVLLSLTGYVFILNITRPVSQIINTIKDISVNNNIKQRIQVTTKNEIGLI 369 Query: 357 ACDINXXXXXXXXXXXXXFNTQARLYESELSQKQAEFSALQSQINPHFLYNTLNCISSIG 416 A + N Q+ +YE +L++ +AEF+AL+SQINPHFLYNTL+CI ++ Sbjct: 370 AYEFNKMLDSIEKMTETILKHQSEIYEVKLAKSRAEFTALKSQINPHFLYNTLDCIRNLA 429 Query: 417 LEYGSREIAQITFCMSKIFRYSIKKDDLVQIWEEVDCIQAYMKIILIRYENKFSMELDVE 476 Y + EI +I M+ IFRYSIK + V + EE++CI Y+KI+ IR+ NKF+ ++++ Sbjct: 430 FMYDAPEIVKIATSMANIFRYSIKGKEYVTLHEEIECINDYLKIMNIRFANKFNTQINIP 489 Query: 477 DRLLKMKTPKMILQPIVENSVYHGLERMDQGGRLLVTGSIDVHGDVCFCITDTGRGMEPE 536 + L K K KMILQPIVEN++YHGLER G L+++ S ++ + I D G+G+ + Sbjct: 490 EELFKAKILKMILQPIVENAIYHGLERKLGNGNLIISAS-AINDILQITIHDDGKGIPED 548 Query: 537 ELAALQAKLGME-YREQASEGQPAKGIGLTNIHNRLRMLFGEGYGITIESRFGEGTTVTV 595 EL+ L A++ E ++ + + G+ N+H R+++ +GE YG+ I S+ EGTTVT+ Sbjct: 549 ELSELLAQMEKEILSSYHNKNEETRSTGIINVHKRIKLYYGESYGLKIYSKLNEGTTVTI 608 Query: 596 KIPKLLDDR 604 +IP +LD++ Sbjct: 609 EIPLILDEQ 617 >B1DAL8.1 B1DAL8_9BACL Signal transduction histidine kinase, LytS Length = 596 Score = 220 bits (560), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 165/601 (27%), Positives = 290/601 (48%), Gaps = 26/601 (4%) Query: 5 KLKLKHQIWLIFFFSIVIFTVMEFYFFYSFSNLTQKRAATYGNQMIEQTRRKIDSVFNDI 64 KL ++ Q+ ++ +I++ V+ + + S + + Y Q + + ++ + S + I Sbjct: 6 KLSIRSQLLILAGSTIIVILVIVLHTYTMMSGMITRSHEEYVRQTVTEMKKNVASNRDVI 65 Query: 65 -RVSTSIAVNSKLIQEFSVVDDDYKRAFDSGPYALDLMEYMRSFNSYVSGIVINDIRGRR 123 R+ I+ N IQ++ V D+ R +D L +Y+ GI I G Sbjct: 66 YRLMQDISYNPD-IQDYLVETDNLVR-YDK---FTKLTKYLSGQKDLKEGIQDIIISGNN 120 Query: 124 LYSLESASGDIFYINRYEAFIRKYKDDPSLREKGMFTTILKDDRTDTEQFFYIAPIVETI 183 ++ A G NRY +R D SL ++ + + IV + Sbjct: 121 DTWIDLAGG-----NRYLVPLRAQLSDQSLNANYEGMRKFENLYGGADMLVFATSIVYSR 175 Query: 184 GGIHFSQITGYCTVMVNMEKMQGLVKNTELTQSSTLYILNNRDEVIASTNSNARGTLF-- 241 G F++ G +V+ + G + + + +Y+L+ +V+AS +S + G+ F Sbjct: 176 PGELFNRNIGTAFFVVDPTALMGEQEYSSKQPGTQIYLLDRDRKVVASNSSLSAGSEFPA 235 Query: 242 --RDVLSMDKDILLNGVKANIDGEDILVQVKGLEQADGWRVVSMIPVHELTADMAPMRKV 299 + S D I+ + +V+ + L + DG V+SM+P +EL D+ +R+ Sbjct: 236 MEENPPSGDNRIV------KWKNQSYVVESETLPEIDG-TVLSMVPENELLRDLLDIRRQ 288 Query: 300 SXXXXXXXXXXXXXXXSFFMNNLMRPVMGLVMDMKRVGRRD---MGFRIKVRFTNEVGLL 356 F +NN++RP+ L+ + + R D + RI + E+ ++ Sbjct: 289 ELIILGIALLMLAIPFMFIVNNILRPLKRLIFFITTLRRGDPLKLKKRISLHGYMEISIV 348 Query: 357 ACDINXXXXXXXXXXXXXFNTQARLYESELSQKQAEFSALQSQINPHFLYNTLNCISSIG 416 A ++N T RLY +EL +K++E + L+SQINPHFLYNTL I+ I Sbjct: 349 ATELNSMLDEIDHLTQSLLETNTRLYSTELEKKKSELAFLRSQINPHFLYNTLEAITGIA 408 Query: 417 LEYGSREIAQITFCMSKIFRYSIKKDDLVQIWEEVDCIQAYMKIILIRYENKFSMELDVE 476 + G +I +T +S IFRYSIK V + EE+ + +Y++I IR+E +F ++ ++ Sbjct: 409 VVEGQDKIKTMTRSLSSIFRYSIKGSSEVPLSEEIRMVDSYIRIQQIRFEGRFDVQYELT 468 Query: 477 DRLLKMKTPKMILQPIVENSVYHGLERMDQGGRLLVTGSIDVHGDVCFCITDTGRGMEPE 536 D + + PKMILQPI EN++YHG E + GRL + G++ G + + D G G+EP Sbjct: 469 DDAMAFRVPKMILQPIAENAIYHGFEPTLKKGRLWIRGAVSGDGQLIVQVEDDGVGIEPA 528 Query: 537 ELAALQAKLGMEYREQASEGQPAKGIGLTNIHNRLRMLFGEGYGITIESRFGEGTTVTVK 596 L L+ + G+ +K IGL N++NR+R++FG G+ ++S G GT V + Sbjct: 529 RLEELRLMMSATSSGPEEHGE-SKSIGLVNVNNRIRLMFGGDCGLRVDSGAGSGTRVELI 587 Query: 597 I 597 I Sbjct: 588 I 588 >B1DGK6.1 B1DGK6_9BACL Histidine kinase internal region Length = 587 Score = 197 bits (501), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 149/600 (24%), Positives = 277/600 (46%), Gaps = 42/600 (7%) Query: 5 KLKLKHQIWLIFFFSIVIFTVMEFYFFYSFSNLTQKRAATYGNQMIEQTRRKIDSVFNDI 64 K L QI ++ +V + + +++ N +++Q K+ S D+ Sbjct: 7 KPSLMRQILILIALMLVTLLITYIITNRIAQQIIERKVTASVNTILQQVNEKMTSFDGDM 66 Query: 65 RVSTSIAVNSKLIQEFSVVDDDYKRAFDSGPYALDLMEYMRSFNSYVSGIVINDIRGRRL 124 + ++ S +Q + DD R + L + S S + GI + D G+ + Sbjct: 67 QGISTFLFYSPTVQTYINTDDMLDRVLMNRE-VLSVFANTMSMKSNIRGIQLYDRSGKLM 125 Query: 125 YSLESASGDIFYINRYEAFIRKYKDDPSLREKGM-FTTILKDDRTDTEQFFYIAPIVETI 183 L +D+ + + M ++ ++ D TE F+ I + + Sbjct: 126 TRLGEG-----------------QDETTAPVQTMSYSGLVNLDDRPTEHFYIITAPIYGL 168 Query: 184 GGIHFS-QITGYCTVMVNMEKMQGLVKNTELTQSSTLYILNNRDEVIASTNSNARGTLFR 242 H + + G ++++ + ++++ ++T +S + +L+ D ++ S Sbjct: 169 DSNHIATEYRGTGRYVMDVSNLSPILRSAKVTANSRVMLLDRNDHILTSEGK-------- 220 Query: 243 DVLSMDKDILLNGVKANIDGEDILVQVKGLEQADGWRVVSMIPVHELTADMAPMRKVSXX 302 +S + + KAN +VQ L + GW+++S+IP EL ++ +++++ Sbjct: 221 --VSSSDSVNVGKWKAN---SKFIVQSITLAPS-GWKLISIIPKSELLNELGTVKRINIT 274 Query: 303 XXXXXXXXXXXXXSFFMNNLMRPVMGLVMDMKRVGRRDMGFRIKVRFTNEVGLLACDINX 362 F +++P+ L+ +K + R +V NE+G+L +N Sbjct: 275 TYAIMFGILCMFLLIFFTRILKPIKSLMDFIKSYPKNGEDSRYQVVHKNEIGVLGQKLNN 334 Query: 363 XXXXXXXXXXXXFNTQARLYESELSQKQAEFSALQSQINPHFLYNTLNCISSIGLEYGSR 422 +TQ R+ E EL++KQ E SA ++QINPHFLYNTL I ++ + R Sbjct: 335 MLDDISELSDEVRSTQIRMLEIELAKKQMEISAFRNQINPHFLYNTLESIRAMAFYHDVR 394 Query: 423 EIAQITFCMSKIFRYSIKKDDLVQIWEEVDCIQAYMKIILIRYENKFSMELDVEDRLLKM 482 +IA I+ +S++FRY++K + V I EE+ I+ Y +II R+ +F + + ++ LL Sbjct: 395 DIADISESLSRMFRYAVKGSNFVTIAEELAHIREYARIIDFRFRGRFKIVIRCDEDLLNE 454 Query: 483 KTPKMILQPIVENSVYHGLERMDQGGRLLVTGSIDVHGD----VCFCITDTGRGMEPEEL 538 KM+LQP+VEN+V+HGLER G +L ID+H + + D G GM +L Sbjct: 455 TMLKMLLQPLVENAVFHGLERKLGEGEVL----IDIHKSADHRIRVLVQDNGYGMNECQL 510 Query: 539 AALQAKLGMEYREQASEGQPAKGIGLTNIHNRLRMLFGEGYGITIESRFGEGTTVTVKIP 598 L+ L + E KGIG++NI+NR + +GE + ++S EGT+V + P Sbjct: 511 QELRDGLIGSQEFVSGEQGKQKGIGISNIYNRTHLFYGEAASLEVDSVLNEGTSVRISFP 570 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.322 0.138 0.395 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,167,756,553 Number of extensions: 124246092 Number of successful extensions: 315793 Number of sequences better than 1.0e-05: 2018 Number of HSP's gapped: 312404 Number of HSP's successfully gapped: 2019 Length of query: 609 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 467 Effective length of database: 1,722,912,073 Effective search space: 804599938091 Effective search space used: 804599938091 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 134 (56.2 bits)