BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0459.0008.p (381 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value A1HPI3.1 A1HPI3_9FIRM Acetyl-CoA acetyltransferases EC=2.3.1.9 444 e-122 Q3ACE6.1 Q3ACE6_CARHZ Acetyl-CoA acetyltransferase EC=2.3.1.9 441 e-122 A6CMV1.1 A6CMV1_9BACI Thiolase (Acetyl-CoA acetyltransferase) 429 e-118 Q2B6B7.1 Q2B6B7_9BACI Thiolase (Acetyl-CoA acetyltransferase) 429 e-118 Q898X5.1 Q898X5_CLOTE Acetyl-coA acetyltransferase EC=2.3.1.9 427 e-118 >A1HPI3.1 A1HPI3_9FIRM Acetyl-CoA acetyltransferases EC=2.3.1.9 Length = 392 Score = 444 bits (1141), Expect = e-122, Method: Compositional matrix adjust. Identities = 217/378 (57%), Positives = 284/378 (75%) Query: 1 VGSFNNGLSTLSATELGADVMTACLQQSRLEPALIDQIYLGNVLQAGIGQNPARQAALKA 60 +GSFN L+ SA ELG+ V+ A L+++ + + +D++ +GNVLQAG+GQNPARQAALKA Sbjct: 14 IGSFNGTLAPFSAPELGSFVIKAALERANVPASAVDEVIMGNVLQAGLGQNPARQAALKA 73 Query: 61 GIPIDVPASTINTVCGSGLHAVALAYNSILAEQGSVLLAGGMESMSNAPYVLKNARNGYK 120 G+P++VP TIN VCGSGL AV LA +I+ +++AGGMESM+NAPY+L +R GY+ Sbjct: 74 GLPVEVPTMTINKVCGSGLKAVNLAAQAIMTGDADIVVAGGMESMTNAPYLLDKSRWGYR 133 Query: 121 LGNGELIDSVVADGLTCPINKYHMGITAENIAAKYNISRLEQDEFAYGSQIKAREAKNKQ 180 +G+G+LIDS++ DGL C N YHMGITAENI KY ++R EQD+ A+ SQ KA +A Sbjct: 134 MGHGKLIDSMITDGLWCAFNDYHMGITAENIVEKYGVTREEQDQLAFESQDKAIKAIASG 193 Query: 181 VFAEQIVPVLTKTKKAEIWFSEDEHVRADTSKEKLSNLKPVFKENGSVTAGNASGINDGA 240 F ++IVPV+ K KK + F DE+ RA T+ EKL LKP FK++G+VTAGNASGINDGA Sbjct: 194 AFKKEIVPVVIKDKKGDKIFDTDEYPRAGTTVEKLCALKPAFKKDGTVTAGNASGINDGA 253 Query: 241 AAVLVMSEDKCKEHAVQPLAYIKGYSLVGVDPAYMGMGPVKAISSLLREQGIPLEAIDLF 300 AA++VMS DK KE ++P+A I+ Y+ GVDP+ MGMGPV A L + G+ ++ IDL Sbjct: 254 AALVVMSADKAKELGIKPMARIRSYASAGVDPSIMGMGPVPATRKALAKAGLVMDDIDLI 313 Query: 301 EINEAFAAQALAVLKELGINPEKVNVNGGAIAIGHPVGASGARILVTLVHEMVRRSSRYG 360 E NEAFAAQ LAV KELG EKVNV+GGAIA+GHP+GASGARILVTL+H M R+ + G Sbjct: 314 EANEAFAAQFLAVGKELGFVKEKVNVHGGAIALGHPIGASGARILVTLLHAMELRNVKTG 373 Query: 361 IASLCIGTGMGIAMLVEN 378 +A+LCIG G G+A +VE Sbjct: 374 LATLCIGGGQGVATIVER 391 >Q3ACE6.1 Q3ACE6_CARHZ Acetyl-CoA acetyltransferase EC=2.3.1.9 Length = 393 Score = 441 bits (1133), Expect = e-122, Method: Compositional matrix adjust. Identities = 219/379 (57%), Positives = 283/379 (74%), Gaps = 1/379 (0%) Query: 1 VGSFNNGLSTLSATELGADVMTACLQQSRLEPALIDQIYLGNVLQAGIGQNPARQAALKA 60 +GSF L+ A +LGA V+ L + L P +D++ +GNVLQAG+GQNPARQAA+KA Sbjct: 14 IGSFLGSLAQTPAVDLGALVIKESLNRINLAPRFVDEVIMGNVLQAGLGQNPARQAAIKA 73 Query: 61 GIPIDVPASTINTVCGSGLHAVALAYNSILAEQGSVLLAGGMESMSNAPYVLKNARNGYK 120 GIP +VPA T+N VCGSGL +V LAY +I +++AGGME+MS APYVL AR GY+ Sbjct: 74 GIPQEVPAFTVNKVCGSGLKSVGLAYQAIATGDADIVVAGGMENMSLAPYVLPKARTGYR 133 Query: 121 LGNGELIDSVVADGLTCPINKYHMGITAENIAAKYNISRLEQDEFAYGSQIKAREAKNKQ 180 +G+ LIDS++ DGL C HMGITAENIA KYNI+R EQD+FA SQ +A +A ++ Sbjct: 134 MGHDTLIDSMIKDGLWCAFTDVHMGITAENIAEKYNITREEQDKFALQSQERAIKAIDEG 193 Query: 181 VFAEQIVPVLTKTKKAE-IWFSEDEHVRADTSKEKLSNLKPVFKENGSVTAGNASGINDG 239 F E+IVPV+ KK E + FS DE + TS EKL+ LKP FK++G+VTAGNASGINDG Sbjct: 194 KFKEEIVPVIIPQKKGEPLVFSTDEFPKRGTSLEKLAALKPAFKKDGTVTAGNASGINDG 253 Query: 240 AAAVLVMSEDKCKEHAVQPLAYIKGYSLVGVDPAYMGMGPVKAISSLLREQGIPLEAIDL 299 AAAV+VMS K +E ++PLA I+GY+ GVDPAYMG+GP+ A L++ + + + L Sbjct: 254 AAAVVVMSAKKAQELNIKPLAVIRGYAAAGVDPAYMGLGPIPATRKALKKANLTVSDLGL 313 Query: 300 FEINEAFAAQALAVLKELGINPEKVNVNGGAIAIGHPVGASGARILVTLVHEMVRRSSRY 359 E NEAFAAQALAV+KEL +NPE NVNGGAIA+GHP+GASGARILVTL+HEM +R+++Y Sbjct: 314 IEANEAFAAQALAVIKELELNPEITNVNGGAIALGHPIGASGARILVTLLHEMQKRNTKY 373 Query: 360 GIASLCIGTGMGIAMLVEN 378 G+A+LCIG G G A++VE Sbjct: 374 GLATLCIGGGQGFALVVEK 392 >A6CMV1.1 A6CMV1_9BACI Thiolase (Acetyl-CoA acetyltransferase) Length = 394 Score = 429 bits (1104), Expect = e-118, Method: Compositional matrix adjust. Identities = 213/380 (56%), Positives = 280/380 (73%), Gaps = 1/380 (0%) Query: 1 VGSFNNGLSTLSATELGADVMTACLQQSRLEPALIDQIYLGNVLQAGIGQNPARQAALKA 60 +GSFN L +SA ELGA V+ L+++ + +D++ +GNVLQAG+GQNPARQAALKA Sbjct: 15 IGSFNGSLKDISAPELGAIVIKNALEKAGVSANDVDEVIMGNVLQAGLGQNPARQAALKA 74 Query: 61 GIPIDVPASTINTVCGSGLHAVALAYNSILAEQGSVLLAGGMESMSNAPYVLKNARNGYK 120 G+P VPA TIN VCGSGL V LA +I+A +++AGGME+MS APY+LKNARNGY+ Sbjct: 75 GMPETVPALTINKVCGSGLKTVHLAAQAIIAGDADIIVAGGMENMSQAPYLLKNARNGYR 134 Query: 121 LGNGELIDSVVADGLTCPINKYHMGITAENIAAKYNISRLEQDEFAYGSQIKAREAKNKQ 180 +G+G+++DS+++DGL C N YHMG+TAEN+ +Y+ISR EQDEFA SQ KA A Sbjct: 135 MGDGKVVDSMISDGLWCAFNDYHMGMTAENLCDRYSISREEQDEFAAWSQEKAAAAMENG 194 Query: 181 VFAEQIVPVLTKTKKAE-IWFSEDEHVRADTSKEKLSNLKPVFKENGSVTAGNASGINDG 239 F +IVPV +K + I F DE R ++ EKL L+ F++ GSVTAGNASGINDG Sbjct: 195 KFDSEIVPVEIPQRKGDPIVFKTDEFPRKSSTAEKLGGLRAAFRKEGSVTAGNASGINDG 254 Query: 240 AAAVLVMSEDKCKEHAVQPLAYIKGYSLVGVDPAYMGMGPVKAISSLLREQGIPLEAIDL 299 AAAV+VMS++K +E + PL I+G + VDPA MG+GPV A+ ++L + + L +DL Sbjct: 255 AAAVVVMSKEKAEELGITPLVTIRGNANAAVDPAVMGIGPVSAVKNVLEKTSLSLADMDL 314 Query: 300 FEINEAFAAQALAVLKELGINPEKVNVNGGAIAIGHPVGASGARILVTLVHEMVRRSSRY 359 E NEAFAAQ+LAV +EL N EK+NVNGGAIA+GHP+GASG RILVTL+HEM RR ++ Sbjct: 315 VEANEAFAAQSLAVDRELTFNKEKLNVNGGAIALGHPIGASGTRILVTLIHEMGRRDAKL 374 Query: 360 GIASLCIGTGMGIAMLVENA 379 G+A+LCIG G G+A +VE A Sbjct: 375 GLATLCIGGGQGVATVVERA 394 >Q2B6B7.1 Q2B6B7_9BACI Thiolase (Acetyl-CoA acetyltransferase) Length = 395 Score = 429 bits (1102), Expect = e-118, Method: Compositional matrix adjust. Identities = 210/378 (55%), Positives = 284/378 (75%), Gaps = 1/378 (0%) Query: 1 VGSFNNGLSTLSATELGADVMTACLQQSRLEPALIDQIYLGNVLQAGIGQNPARQAALKA 60 +GSFN L +SA LGA + L+++ LE +D++ +GNVLQAG+GQNPARQAA+ A Sbjct: 16 IGSFNGSLKGVSAPALGAAAIKGALEKAGLEAEQVDEVIMGNVLQAGLGQNPARQAAILA 75 Query: 61 GIPIDVPASTINTVCGSGLHAVALAYNSILAEQGSVLLAGGMESMSNAPYVLKNARNGYK 120 GIP V + TIN VCGSGL AV LAY +I+A V++AGGME+MS APY+LK AR+G+K Sbjct: 76 GIPESVSSMTINKVCGSGLKAVHLAYQAIMAGDAEVVVAGGMENMSQAPYLLKGARDGFK 135 Query: 121 LGNGELIDSVVADGLTCPINKYHMGITAENIAAKYNISRLEQDEFAYGSQIKAREAKNKQ 180 +G+ +L+DS+V+DGL C N YHMG+TAE + +Y +SR EQD FA SQ KA++A+ Sbjct: 136 MGDQKLVDSMVSDGLWCAFNDYHMGMTAEKLCLQYGLSREEQDTFAAWSQEKAQKAQEAG 195 Query: 181 VFAEQIVPVLTKTKKAE-IWFSEDEHVRADTSKEKLSNLKPVFKENGSVTAGNASGINDG 239 F ++IVPV +K + + F DE+++ T+ EKL+ L+P FK++GSVTAGNASGINDG Sbjct: 196 RFKDEIVPVEIPQRKGDPVIFDSDEYLKKGTTAEKLAGLRPAFKKDGSVTAGNASGINDG 255 Query: 240 AAAVLVMSEDKCKEHAVQPLAYIKGYSLVGVDPAYMGMGPVKAISSLLREQGIPLEAIDL 299 AAA++VMS K +E VQP+A I+ + GVDP+ MG+GPV A+ +L + G+ +E +DL Sbjct: 256 AAALVVMSRAKAEELGVQPIAVIRANASAGVDPSIMGIGPVPAVKKVLEKAGVSMEELDL 315 Query: 300 FEINEAFAAQALAVLKELGINPEKVNVNGGAIAIGHPVGASGARILVTLVHEMVRRSSRY 359 E NEAFAAQ+LAV KELG N E +NVNGGAIA+GHP+GASGAR+LVTL+HEM +R++ Sbjct: 316 IEANEAFAAQSLAVGKELGFNNEILNVNGGAIALGHPIGASGARVLVTLLHEMKKRNAEK 375 Query: 360 GIASLCIGTGMGIAMLVE 377 G+A+LCIG G G+A +VE Sbjct: 376 GLAALCIGGGQGVATVVE 393 >Q898X5.1 Q898X5_CLOTE Acetyl-coA acetyltransferase EC=2.3.1.9 Length = 391 Score = 427 bits (1099), Expect = e-118, Method: Compositional matrix adjust. Identities = 211/378 (55%), Positives = 278/378 (73%) Query: 1 VGSFNNGLSTLSATELGADVMTACLQQSRLEPALIDQIYLGNVLQAGIGQNPARQAALKA 60 +G F L + A ELGA V+ + ++ ++P +ID++ +GNV+QAG+GQ+P RQAA+KA Sbjct: 14 MGKFGGTLKDVPAVELGATVIKEAINRAGIKPEIIDEVIMGNVIQAGLGQSPGRQAAVKA 73 Query: 61 GIPIDVPASTINTVCGSGLHAVALAYNSILAEQGSVLLAGGMESMSNAPYVLKNARNGYK 120 GIP++VPA T+N VCGSGL AV LA I A V++AGGME+MS APYVL NAR G + Sbjct: 74 GIPVEVPAFTLNKVCGSGLRAVGLAAQMIKAGDADVVIAGGMENMSAAPYVLPNARWGQR 133 Query: 121 LGNGELIDSVVADGLTCPINKYHMGITAENIAAKYNISRLEQDEFAYGSQIKAREAKNKQ 180 + +G+++D++V DGL N YHMG+TAENIA K+ ++R QDEFA SQ KA +A + Sbjct: 134 MFDGKMVDTMVKDGLWESFNDYHMGMTAENIAEKWELTREMQDEFACASQNKAEKAIKEG 193 Query: 181 VFAEQIVPVLTKTKKAEIWFSEDEHVRADTSKEKLSNLKPVFKENGSVTAGNASGINDGA 240 F ++IVPV+ KT+K E+ F DE R + E L+ LKP FK++G+VTAGNASGINDGA Sbjct: 194 KFKDEIVPVVIKTRKGEVVFDTDEFPRFGATVESLAKLKPAFKKDGTVTAGNASGINDGA 253 Query: 241 AAVLVMSEDKCKEHAVQPLAYIKGYSLVGVDPAYMGMGPVKAISSLLREQGIPLEAIDLF 300 AA+++MS +K +E ++PLA I Y G+DPAYMG GPV A L + G +E +DL Sbjct: 254 AALVIMSAEKAEELGLKPLAKIASYGSKGLDPAYMGYGPVGATKVALEKAGWKVEDLDLI 313 Query: 301 EINEAFAAQALAVLKELGINPEKVNVNGGAIAIGHPVGASGARILVTLVHEMVRRSSRYG 360 E NEAFA+Q+LAV K+LG + EKVNVNGGAIA+GHPVG SGARILVTL+HEM RR S+ G Sbjct: 314 EANEAFASQSLAVAKDLGFDMEKVNVNGGAIALGHPVGCSGARILVTLLHEMQRRDSKKG 373 Query: 361 IASLCIGTGMGIAMLVEN 378 +A+LCIG GMG A+LVE Sbjct: 374 LATLCIGGGMGTALLVER 391 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.315 0.132 0.368 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,121,265,438 Number of extensions: 86670142 Number of successful extensions: 304787 Number of sequences better than 1.0e-05: 5210 Number of HSP's gapped: 292898 Number of HSP's successfully gapped: 5262 Length of query: 381 Length of database: 3,060,696,203 Length adjustment: 137 Effective length of query: 244 Effective length of database: 1,770,017,148 Effective search space: 431884184112 Effective search space used: 431884184112 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 132 (55.5 bits)