BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0442.0012.p (515 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KA83.1 B3KA83_9BACI Phosphoribosylaminoimidazolecarboxamide fo... 921 0.0 B1D8Y9.1 B1D8Y9_9BACL Phosphoribosylaminoimidazolecarboxamide fo... 828 0.0 C0ZKD2.1 C0ZKD2_BREBN Phosphoribosylaminoimidazolecarboxamide fo... 769 0.0 C5D4I4.1 C5D4I4_9BACI Phosphoribosylaminoimidazolecarboxamide fo... 751 0.0 C2Y582.1 C2Y582_BACCE IMP cyclohydrolase 740 0.0 >B3KA83.1 B3KA83_9BACI Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase EC=3.5.4.10 Length = 515 Score = 921 bits (2380), Expect = 0.0, Method: Compositional matrix adjust. Identities = 438/515 (85%), Positives = 482/515 (93%) Query: 1 VSIKRALVSVSDKQGIVDFCRGLSALGVEIISTGGTSTLLAKEGVPVIGISDVTGFPEIM 60 + IKRALVSVSDK G+V+FCR LS+LGVEIISTGGT LLAKEGVPVIGISDVTGFPEI+ Sbjct: 1 MGIKRALVSVSDKTGVVEFCRELSSLGVEIISTGGTKNLLAKEGVPVIGISDVTGFPEIL 60 Query: 61 DGRVKTLHPAVHSGLLAVRDNEEHTRQMQELGLDYIDLVVVNLYPFAETIAKADVSYEEA 120 DGRVKTLHPAVHSGLLA+RD++EH RQMQELGLDYIDLVVVNLYPF ETIAK DV YE+A Sbjct: 61 DGRVKTLHPAVHSGLLAIRDSKEHQRQMQELGLDYIDLVVVNLYPFQETIAKPDVEYEDA 120 Query: 121 IENIDIGGPTMLRSAAKNHAFVSVVVDAADYATVLEEVRAGGDTTLETRKRLAAKVFRHT 180 IENIDIGGPTMLRSAAKNHAFVSVVVDAADY +V+EE+R GGDTTLETRKRLAAKVFRHT Sbjct: 121 IENIDIGGPTMLRSAAKNHAFVSVVVDAADYGSVIEEIRGGGDTTLETRKRLAAKVFRHT 180 Query: 181 AAYDALISDYLANVTGEPLPERYTVTYEKIQDLRYGENPHQKAAFYRKPLAAQDTLTSAE 240 AAYD LISDYL+NVTG+PLPER++VTYEKIQDLRYGENPHQKAAFYRKPLA TLT+AE Sbjct: 181 AAYDTLISDYLSNVTGDPLPERFSVTYEKIQDLRYGENPHQKAAFYRKPLAPAGTLTTAE 240 Query: 241 QLHGKELSYNNINDANAALQIVKEFEEPAVVAVKHMNPCGVGVGASVYEAYQKAYNADPT 300 QLHGKELSYNNINDANAALQIVKEF+EP VVAVKHMNPCGVG+G +V EAYQKAYNADPT Sbjct: 241 QLHGKELSYNNINDANAALQIVKEFDEPTVVAVKHMNPCGVGIGTNVLEAYQKAYNADPT 300 Query: 301 SIFGGIVAANRIIDADTANMLKDIFLEIVLAPGFTEEALDILTKKKNIRLLKLGNLSTAA 360 SIFGGIVAANR IDA TA++LKDIFLEI+LAP FT EAL+ILTKKKNIRLLK+G +A Sbjct: 301 SIFGGIVAANRTIDAPTADLLKDIFLEIILAPDFTPEALEILTKKKNIRLLKMGEFGSAK 360 Query: 361 ARKSSFVVTSIEGGMVVQESDVHSVNPEELQVVTNRKPTEEELKQLLFGWKVVKHVKSNA 420 R+S+ VT+IEGGM+VQESDVHS++ +L+VVT+R+PTE ELKQLLFGWKVVKHVKSNA Sbjct: 361 ERQSTLAVTTIEGGMIVQESDVHSLDAADLKVVTDREPTEAELKQLLFGWKVVKHVKSNA 420 Query: 421 IVLAADDMTVGVGAGQMNRVGAAKIAIEQAGEKAKGSVLASDAFFPMGDTLEMAAKAGIT 480 I+LAADDMTVGVGAGQMNRVG+A+IA+EQAGEKAKG+VLASDAFFPMGDT+E+AAKAGIT Sbjct: 421 IILAADDMTVGVGAGQMNRVGSARIAVEQAGEKAKGAVLASDAFFPMGDTVELAAKAGIT 480 Query: 481 AVIQPGGSIKDEESIKVANEYGIAMVFTGVRHFKH 515 A+IQPGGSIKDEESIK ANEYGIAMVFTGVRHFKH Sbjct: 481 AIIQPGGSIKDEESIKAANEYGIAMVFTGVRHFKH 515 >B1D8Y9.1 B1D8Y9_9BACL Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase EC=2.1.2.3 Length = 516 Score = 828 bits (2138), Expect = 0.0, Method: Compositional matrix adjust. Identities = 404/516 (78%), Positives = 458/516 (88%), Gaps = 1/516 (0%) Query: 1 VSIKRALVSVSDKQGIVDFCRGLSALGVEIISTGGTSTLLAKEGVPVIGISDVTGFPEIM 60 ++I+RAL+SVSDK GIV+F R L+A GV+IISTGGT LL KEG+PVIGISDVTGFPEI+ Sbjct: 1 MAIRRALISVSDKTGIVEFSRELAAQGVQIISTGGTFNLLEKEGIPVIGISDVTGFPEIL 60 Query: 61 DGRVKTLHPAVHSGLLAVRDNEEHTRQMQELGLDYIDLVVVNLYPFAETIAKADVSYEEA 120 DGRVKTLHPAVHSGLLA+RDNEEH + MQELGLDYIDLVVVNLYPF +TIA +V YE+A Sbjct: 61 DGRVKTLHPAVHSGLLAIRDNEEHQKVMQELGLDYIDLVVVNLYPFKQTIANPNVEYEDA 120 Query: 121 IENIDIGGPTMLRSAAKNHAFVSVVVDAADYATVLEEVRAGGDTTLETRKRLAAKVFRHT 180 IENIDIGGPTMLRSAAKNHAFV+VVVDA DYA V+EE++AGGDTTLETRKRL AKVFRHT Sbjct: 121 IENIDIGGPTMLRSAAKNHAFVTVVVDANDYAAVIEEIKAGGDTTLETRKRLTAKVFRHT 180 Query: 181 AAYDALISDYLANVTGEPLPERYTVTYEKIQDLRYGENPHQKAAFYRKPLAAQDTLTSAE 240 AAYDALI+DYL GE LPE YTVTYEK+QDLRYGENPHQKAAFY KPLA +T+AE Sbjct: 181 AAYDALIADYLTKQVGEELPESYTVTYEKVQDLRYGENPHQKAAFYSKPLAPVGNITTAE 240 Query: 241 QLHGKELSYNNINDANAALQIVKEFEEPAVVAVKHMNPCGVGVGASVYEAYQKAYNADPT 300 QLHGKELSYNNINDANAAL IVKEF+EPA VAVKHMNPCGVG+GA ++EAYQKAY ADPT Sbjct: 241 QLHGKELSYNNINDANAALAIVKEFDEPACVAVKHMNPCGVGIGADIHEAYQKAYAADPT 300 Query: 301 SIFGGIVAANRIIDADTANMLKDIFLEIVLAPGFTEEALDILTKKKNIRLLKLGNLS-TA 359 SIFGGIVAANR I +TA +L IFLEI++AP FT EAL++LTKKKNIRLLKLG L+ +A Sbjct: 301 SIFGGIVAANRTIGVETAELLSQIFLEIIIAPDFTPEALEVLTKKKNIRLLKLGELAGSA 360 Query: 360 AARKSSFVVTSIEGGMVVQESDVHSVNPEELQVVTNRKPTEEELKQLLFGWKVVKHVKSN 419 A RKS ++ T+++GG++VQESDV S+ +LQ VTNRKPTEEELKQLLFGWKVVKHVKSN Sbjct: 361 AERKSDWLSTTVDGGLLVQESDVRSLTEADLQFVTNRKPTEEELKQLLFGWKVVKHVKSN 420 Query: 420 AIVLAADDMTVGVGAGQMNRVGAAKIAIEQAGEKAKGSVLASDAFFPMGDTLEMAAKAGI 479 AI+LA ++MT+GVGAGQMNRVGAA+IAIEQAG+KA G+VLASDAFFPMGDT+E+AAK GI Sbjct: 421 AILLAKNNMTIGVGAGQMNRVGAARIAIEQAGDKAAGAVLASDAFFPMGDTVELAAKHGI 480 Query: 480 TAVIQPGGSIKDEESIKVANEYGIAMVFTGVRHFKH 515 TA+IQ GGSIKDEESI AN + IAMV TGVRHFKH Sbjct: 481 TAIIQTGGSIKDEESIAAANAHNIAMVMTGVRHFKH 516 >C0ZKD2.1 C0ZKD2_BREBN Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase EC=2.1.2.3 EC=3.5.4.1 Length = 516 Score = 769 bits (1985), Expect = 0.0, Method: Compositional matrix adjust. Identities = 369/516 (71%), Positives = 436/516 (84%), Gaps = 1/516 (0%) Query: 1 VSIKRALVSVSDKQGIVDFCRGLSALGVEIISTGGTSTLLAKEGVPVIGISDVTGFPEIM 60 +S+K+AL+SVSDK G++ F R L A GV+IISTGGT++LL EGVPVIGIS+VTGFPEI+ Sbjct: 1 MSVKKALISVSDKTGLIPFARRLVAAGVQIISTGGTASLLKAEGVPVIGISEVTGFPEIL 60 Query: 61 DGRVKTLHPAVHSGLLAVRDNEEHTRQMQELGLDYIDLVVVNLYPFAETIAKADVSYEEA 120 DGRVKTLHP +HSGLLAVRD+E H +Q+++LG++ IDLVVVNLYPF ETIAK DV+YE+A Sbjct: 61 DGRVKTLHPNIHSGLLAVRDSEAHVQQLKDLGIETIDLVVVNLYPFKETIAKPDVTYEDA 120 Query: 121 IENIDIGGPTMLRSAAKNHAFVSVVVDAADYATVLEEVRAGGDTTLETRKRLAAKVFRHT 180 IENIDIGGPTMLRSAAKNHAFVSVVVDAADY V EE+ A GDTTLETR++LAAKVFRHT Sbjct: 121 IENIDIGGPTMLRSAAKNHAFVSVVVDAADYEKVAEEIEANGDTTLETRRKLAAKVFRHT 180 Query: 181 AAYDALISDYLANVTGEPLPERYTVTYEKIQDLRYGENPHQKAAFYRKPLAAQDTLTSAE 240 AAYDALIS YL+ GE LPE YTVTYEK QDLRYGENPHQ+AAFYR+PL+ Q ++ +A Sbjct: 181 AAYDALISRYLSEQVGELLPESYTVTYEKAQDLRYGENPHQRAAFYREPLSDQLSIGNAS 240 Query: 241 QLHGKELSYNNINDANAALQIVKEFEEPAVVAVKHMNPCGVGVGASVYEAYQKAYNADPT 300 QL GKELSYNNINDA+AAL IV+EF EPAVVA+KH NPCGVG+GA + AYQKAY ADP Sbjct: 241 QLQGKELSYNNINDADAALAIVREFAEPAVVAIKHSNPCGVGIGADIRSAYQKAYEADPV 300 Query: 301 SIFGGIVAANRIIDADTANMLKDIFLEIVLAPGFTEEALDILTKKKNIRLLKLGNLSTAA 360 SIFGGIVAANR ID DTA +K+IFLEI++AP FTEEAL +L +KKN+RLL++ L+ A Sbjct: 301 SIFGGIVAANRPIDRDTALAMKEIFLEIIIAPDFTEEALAVLAEKKNLRLLRISALNEPA 360 Query: 361 ARKSS-FVVTSIEGGMVVQESDVHSVNPEELQVVTNRKPTEEELKQLLFGWKVVKHVKSN 419 + + F V + GG ++Q+ D + E+QVVT+RKP+EEE+ QL F WKVVKHVKSN Sbjct: 361 KKVDNLFRVAPVAGGALIQDFDYKQLEENEIQVVTDRKPSEEEMAQLKFAWKVVKHVKSN 420 Query: 420 AIVLAADDMTVGVGAGQMNRVGAAKIAIEQAGEKAKGSVLASDAFFPMGDTLEMAAKAGI 479 AI+LA D+MT+GVGAGQMNRVGAAKIAIEQAG A G+V+ASDAFFPMGDT+E AAKAGI Sbjct: 421 AILLAKDNMTIGVGAGQMNRVGAAKIAIEQAGALASGAVMASDAFFPMGDTVEAAAKAGI 480 Query: 480 TAVIQPGGSIKDEESIKVANEYGIAMVFTGVRHFKH 515 TA+IQPGGSI+D+ESI N GIAM+FTG RHFKH Sbjct: 481 TAIIQPGGSIRDQESIDACNRAGIAMIFTGTRHFKH 516 >C5D4I4.1 C5D4I4_9BACI Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase EC=2.1.2.3 Length = 512 Score = 751 bits (1938), Expect = 0.0, Method: Compositional matrix adjust. Identities = 360/515 (69%), Positives = 434/515 (84%), Gaps = 3/515 (0%) Query: 1 VSIKRALVSVSDKQGIVDFCRGLSALGVEIISTGGTSTLLAKEGVPVIGISDVTGFPEIM 60 +++KRAL+SVS+K+GIV + L LGVEIISTGGT L + GVPVIGISDVTGFPEI+ Sbjct: 1 MAVKRALLSVSNKEGIVSLAKQLVELGVEIISTGGTKKTLEEAGVPVIGISDVTGFPEIL 60 Query: 61 DGRVKTLHPAVHSGLLAVRDNEEHTRQMQELGLDYIDLVVVNLYPFAETIAKADVSYEEA 120 DGRVKTLHP +H GLLA+RDNE H +++E + IDLVVVNLYPF +TIAK+DV++ EA Sbjct: 61 DGRVKTLHPMIHGGLLAIRDNERHQSELREHHITPIDLVVVNLYPFQQTIAKSDVTFAEA 120 Query: 121 IENIDIGGPTMLRSAAKNHAFVSVVVDAADYATVLEEVRAGGDTTLETRKRLAAKVFRHT 180 IENIDIGGPTMLR+AAKNH +V+VVVD ADY TV++E++ GD ++ET+ +LAAKVFRHT Sbjct: 121 IENIDIGGPTMLRAAAKNHQYVTVVVDPADYDTVVQELKKHGDVSVETKLKLAAKVFRHT 180 Query: 181 AAYDALISDYLANVTGEPLPERYTVTYEKIQDLRYGENPHQKAAFYRKPLAAQDTLTSAE 240 AAYDA+I++YL N TGE PE T+T+EK Q LRYGENPHQ AAFY+KPL A ++ A Sbjct: 181 AAYDAMIAEYLTNKTGEEYPESLTITFEKKQALRYGENPHQTAAFYKKPLGASFSIAQAM 240 Query: 241 QLHGKELSYNNINDANAALQIVKEFEEPAVVAVKHMNPCGVGVGASVYEAYQKAYNADPT 300 QLHGKELSYNNINDANAALQIVKEF EPA VAVKHMNPCGVGVGA++YEA+ KAY ADPT Sbjct: 241 QLHGKELSYNNINDANAALQIVKEFTEPAAVAVKHMNPCGVGVGATIYEAFTKAYEADPT 300 Query: 301 SIFGGIVAANRIIDADTANMLKDIFLEIVLAPGFTEEALDILTKKKNIRLLKLGNLSTAA 360 SIFGGI+A NR +D +TA + +IFLEIV+AP F++EALDILT+KKNIRLL + TA Sbjct: 301 SIFGGIIALNREVDKETAEKMHEIFLEIVIAPSFSKEALDILTQKKNIRLLTVD--FTAP 358 Query: 361 ARKSSFVVTSIEGGMVVQESDVHSVNPEELQVVTNRKPTEEELKQLLFGWKVVKHVKSNA 420 K +V S++GG++VQE+D H+++ E++VVT R+PTE+E + L F WKVVKHVKSNA Sbjct: 359 NTKEKLLV-SVQGGLLVQETDTHTLDDAEIKVVTKREPTEQEWEALRFAWKVVKHVKSNA 417 Query: 421 IVLAADDMTVGVGAGQMNRVGAAKIAIEQAGEKAKGSVLASDAFFPMGDTLEMAAKAGIT 480 IVLA D MT+G+GAGQMNRVGAAKIAIEQAGEKAKG+VLASDAFFPM DT+E AAKAGIT Sbjct: 418 IVLAKDGMTIGIGAGQMNRVGAAKIAIEQAGEKAKGAVLASDAFFPMDDTVEAAAKAGIT 477 Query: 481 AVIQPGGSIKDEESIKVANEYGIAMVFTGVRHFKH 515 A+IQPGGSI+D +SIK A+EYGIAMVFTG+RHFKH Sbjct: 478 AIIQPGGSIRDADSIKKADEYGIAMVFTGIRHFKH 512 >C2Y582.1 C2Y582_BACCE IMP cyclohydrolase Length = 511 Score = 740 bits (1910), Expect = 0.0, Method: Compositional matrix adjust. Identities = 358/513 (69%), Positives = 421/513 (82%), Gaps = 5/513 (0%) Query: 4 KRALVSVSDKQGIVDFCRGLSALGVEIISTGGTSTLLAKEGVPVIGISDVTGFPEIMDGR 63 KRALVSVSDK G+V+F +GL A G+E+ISTGGT LL + G+ VIGIS+VTGFPEIMDGR Sbjct: 3 KRALVSVSDKTGVVEFVKGLLAQGIEVISTGGTKKLLEENGLQVIGISEVTGFPEIMDGR 62 Query: 64 VKTLHPAVHSGLLAVRDNEEHTRQMQELGLDYIDLVVVNLYPFAETIAKADVSYEEAIEN 123 VKTLHP +H GLLAVRDNE H QM ELG++ ID VVVNLYPF ETIAK DV++ +AIEN Sbjct: 63 VKTLHPNIHGGLLAVRDNETHVTQMNELGMEPIDFVVVNLYPFKETIAKPDVTFADAIEN 122 Query: 124 IDIGGPTMLRSAAKNHAFVSVVVDAADYATVLEEVRAGGDTTLETRKRLAAKVFRHTAAY 183 IDIGGPTM+RSAAKNH FVSV+VD DY VL E++ G+ ET+++LAAKVFRHTAAY Sbjct: 123 IDIGGPTMIRSAAKNHKFVSVIVDPVDYDIVLAELKENGEVAEETKRKLAAKVFRHTAAY 182 Query: 184 DALISDYLANVTGEPLPERYTVTYEKIQDLRYGENPHQKAAFYRKPLAAQDTLTSAEQLH 243 DALIS+YL GE PE TVT+EK QDLRYGENPHQKA FY+ P AA ++ AEQLH Sbjct: 183 DALISNYLTEQMGEESPETLTVTFEKKQDLRYGENPHQKATFYKAPFAATSSVAYAEQLH 242 Query: 244 GKELSYNNINDANAALQIVKEFEEPAVVAVKHMNPCGVGVGASVYEAYQKAYNADPTSIF 303 GKELSYNNINDA+AAL IVKEF EPAVVAVKHMNPCGVGVG ++EAY +AY ADP SIF Sbjct: 243 GKELSYNNINDADAALSIVKEFTEPAVVAVKHMNPCGVGVGTDIHEAYTRAYEADPVSIF 302 Query: 304 GGIVAANRIIDADTANMLKDIFLEIVLAPGFTEEALDILTKKKNIRLLKLG-NLSTAAAR 362 GGI+AANR ID TA L +IFLEIV+AP F++EAL++L KKN+RLL + +T+A++ Sbjct: 303 GGIIAANREIDKATAEKLHEIFLEIVIAPSFSQEALEVLQSKKNLRLLTINIEKATSASK 362 Query: 363 KSSFVVTSIEGGMVVQESDVHSVNPEELQVVTNRKPTEEELKQLLFGWKVVKHVKSNAIV 422 K +TS++GG++VQE D S++ + + T R+P+E+E K L WKVVKHVKSNAIV Sbjct: 363 K----LTSVQGGLLVQEEDTLSLDESTISIPTKREPSEQEWKDLKLAWKVVKHVKSNAIV 418 Query: 423 LAADDMTVGVGAGQMNRVGAAKIAIEQAGEKAKGSVLASDAFFPMGDTLEMAAKAGITAV 482 LA DDMT+GVGAGQMNRVG+AKIAI QAGEKA+GS LASDAFFPM DTLE AAKAGITA+ Sbjct: 419 LAKDDMTIGVGAGQMNRVGSAKIAITQAGEKAQGSALASDAFFPMPDTLEEAAKAGITAI 478 Query: 483 IQPGGSIKDEESIKVANEYGIAMVFTGVRHFKH 515 IQPGGSI+DE+SIKVA+ YGIAMVFTGVRHFKH Sbjct: 479 IQPGGSIRDEDSIKVADTYGIAMVFTGVRHFKH 511 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.316 0.132 0.365 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,900,183,377 Number of extensions: 119108470 Number of successful extensions: 366402 Number of sequences better than 1.0e-05: 1718 Number of HSP's gapped: 358058 Number of HSP's successfully gapped: 1826 Length of query: 515 Length of database: 3,060,696,203 Length adjustment: 140 Effective length of query: 375 Effective length of database: 1,741,754,103 Effective search space: 653157788625 Effective search space used: 653157788625 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 134 (56.2 bits)