BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0442.0009.p (346 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KA81.1 B3KA81_9BACI Phosphoribosylformylglycinamidine cyclo-li... 559 e-157 B1D8Y7.1 B1D8Y7_9BACL Phosphoribosylformylglycinamidine cyclo-li... 499 e-139 C0ZKC8.1 PUR5_BREBN Phosphoribosylformylglycinamidine cyclo-liga... 482 e-134 C5D4I2.1 C5D4I2_9BACI Phosphoribosylformylglycinamidine cyclo-li... 431 e-119 Q4MHX5.1 Q4MHX5_BACCE Phosphoribosylformylglycinamidine cyclo-li... 409 e-112 >B3KA81.1 B3KA81_9BACI Phosphoribosylformylglycinamidine cyclo-ligase EC=6.3.3.1 Length = 346 Score = 559 bits (1440), Expect = e-157, Method: Compositional matrix adjust. Identities = 272/346 (78%), Positives = 303/346 (87%) Query: 1 VSEAYKNAGVDIAAGNEAVERMKKHVKRTFRPEVMTELGGFGALFGLNKDKYEEPVLVSG 60 +S+ YK AGVDIAAGNEAVERMKKHVK TFRPEVMT+LGGFGALF LNKD+YEEPVLVSG Sbjct: 1 MSDTYKQAGVDIAAGNEAVERMKKHVKTTFRPEVMTDLGGFGALFKLNKDQYEEPVLVSG 60 Query: 61 TDGVGTKLKIAFAADRHDTIGIDAVAMCVNDIVVQGAEPLFFLDYLACDKVVPEKIEAIV 120 TDGVGTKLK+AFA D+HDTIGIDAVAMCVNDIVVQGAEPLFFLDYLACDKV+P KIE+IV Sbjct: 61 TDGVGTKLKLAFAMDQHDTIGIDAVAMCVNDIVVQGAEPLFFLDYLACDKVIPSKIESIV 120 Query: 121 AGIAEGCHQAGCALIGGETAEMPGMYSAGEYDIAGFTVGVADKAKLVTGADIAPGDTVIG 180 GIA+GC+QAGC+LIGGETAEMPGMYS GEYDIAGFTVG+ DK+K++ G++IA GDTVIG Sbjct: 121 KGIADGCNQAGCSLIGGETAEMPGMYSEGEYDIAGFTVGIVDKSKMINGSNIAAGDTVIG 180 Query: 181 LASSGVHSNGFSLVRKLLLEEDGYGLNDVVPELGAPLVDVLLAPTKIYVKPLLGLLEQLP 240 LASSGVHSNGFSLVRKLLLE+ GY L +PELG L DVLLAPTKIYVKPLL LL+++ Sbjct: 181 LASSGVHSNGFSLVRKLLLEDAGYSLQQELPELGGRLGDVLLAPTKIYVKPLLELLKEIE 240 Query: 241 VKGMAHITGGGFIENIPRVLPEGVNVDINYGSWPVLPIFDLLQKKGGVSNRDMFTTFNMG 300 VKGMAHITGGGFIENIPR+LP+GVNVDI YGSWP+LPIF L+Q+KG +SN+DMFTTFNMG Sbjct: 241 VKGMAHITGGGFIENIPRMLPDGVNVDIEYGSWPILPIFKLMQEKGDISNKDMFTTFNMG 300 Query: 301 VGLVLVVAEADGXXXXXXXXXXXXXXXXIGRVTEGERIVTFTGAEV 346 +G+VLVV E D IGRVTEGERIVTFTGAEV Sbjct: 301 IGMVLVVKEQDADGVLQFLRSAGEEAYAIGRVTEGERIVTFTGAEV 346 >B1D8Y7.1 B1D8Y7_9BACL Phosphoribosylformylglycinamidine cyclo-ligase EC=6.3.3.1 Length = 347 Score = 499 bits (1284), Expect = e-139, Method: Compositional matrix adjust. Identities = 254/347 (73%), Positives = 291/347 (83%), Gaps = 1/347 (0%) Query: 1 VSEAYKNAGVDIAAGNEAVERMKKHVKRTFRPEVMTELGGFGALFGLNKDKYEEPVLVSG 60 +SEAYK AGVDIAAGNEAVERMKKHVK+TFRPEV+T+LGGFG LFGLNKDKYEEPVLVSG Sbjct: 1 MSEAYKKAGVDIAAGNEAVERMKKHVKKTFRPEVLTDLGGFGGLFGLNKDKYEEPVLVSG 60 Query: 61 TDGVGTKLKIAFAADRHDTIGIDAVAMCVNDIVVQGAEPLFFLDYLACDKVVPEKIEAIV 120 TDGVGTKLK+AF D+HDTIG+DAVAMCVNDI+VQGAEPLFFLDYLAC KVVPEKIEA+V Sbjct: 61 TDGVGTKLKLAFLMDKHDTIGVDAVAMCVNDIIVQGAEPLFFLDYLACGKVVPEKIEAVV 120 Query: 121 AGIAEGCHQAGCALIGGETAEMPGMYSAGEYDIAGFTVGVADKAKLVTGADIAPGDTVIG 180 GI++GC QAGCALIGGETAEMPGMY EYDIAGFTVGV DK K++ G IAPGD V+G Sbjct: 121 KGISDGCVQAGCALIGGETAEMPGMYQGDEYDIAGFTVGVVDKKKIIDGTTIAPGDVVLG 180 Query: 181 LASSGVHSNGFSLVRKLLLEEDGYGLNDVVPELGAPLV-DVLLAPTKIYVKPLLGLLEQL 239 ASSG+HSNG+SLVR+LLLEE GY L+ +PEL ++ DVL+ PT+IYVK L L+EQ+ Sbjct: 181 FASSGIHSNGYSLVRRLLLEECGYALDQRLPELNDEVLGDVLIEPTRIYVKSALKLIEQV 240 Query: 240 PVKGMAHITGGGFIENIPRVLPEGVNVDINYGSWPVLPIFDLLQKKGGVSNRDMFTTFNM 299 VKGMAHITGGGFIENIPRVLPEGVNV++ YGSWP+LPIF L+Q+KG ++NRDMFTTFNM Sbjct: 241 NVKGMAHITGGGFIENIPRVLPEGVNVNVEYGSWPILPIFQLMQEKGAITNRDMFTTFNM 300 Query: 300 GVGLVLVVAEADGXXXXXXXXXXXXXXXXIGRVTEGERIVTFTGAEV 346 G+GL++VV IG VTEG R+VTFTGA+V Sbjct: 301 GIGLIVVVPAEQAEEALKAAAELGEAAYRIGTVTEGNRVVTFTGADV 347 >C0ZKC8.1 PUR5_BREBN Phosphoribosylformylglycinamidine cyclo-ligase EC=6.3.3.1 Length = 346 Score = 482 bits (1240), Expect = e-134, Method: Compositional matrix adjust. Identities = 238/345 (68%), Positives = 274/345 (79%) Query: 1 VSEAYKNAGVDIAAGNEAVERMKKHVKRTFRPEVMTELGGFGALFGLNKDKYEEPVLVSG 60 +SEAYK AGVDI AGNEAVERMKKHVKRTFRPEVMT+LGGFGALF L+ KYE+P+LVSG Sbjct: 1 MSEAYKQAGVDIDAGNEAVERMKKHVKRTFRPEVMTDLGGFGALFRLDTKKYEKPILVSG 60 Query: 61 TDGVGTKLKIAFAADRHDTIGIDAVAMCVNDIVVQGAEPLFFLDYLACDKVVPEKIEAIV 120 TDGVGTKLK+AFA D+HDTIGIDAVAMCVND+VVQGAEPLFFLDYLA DKV+PEKIEAIV Sbjct: 61 TDGVGTKLKLAFAMDKHDTIGIDAVAMCVNDVVVQGAEPLFFLDYLAVDKVIPEKIEAIV 120 Query: 121 AGIAEGCHQAGCALIGGETAEMPGMYSAGEYDIAGFTVGVADKAKLVTGADIAPGDTVIG 180 GIAEGC Q+GC+LIGGETAEMPGMY+ GEYDIAGFTVGV D++K++TGA +A GD +IG Sbjct: 121 KGIAEGCSQSGCSLIGGETAEMPGMYAEGEYDIAGFTVGVVDESKMITGASVAAGDVLIG 180 Query: 181 LASSGVHSNGFSLVRKLLLEEDGYGLNDVVPELGAPLVDVLLAPTKIYVKPLLGLLEQLP 240 LASSGVHSNGFSLVRK+LL + G L+D V LG L + LL PT+IYVK +L +LE Sbjct: 181 LASSGVHSNGFSLVRKVLLADKGMSLHDHVDVLGKKLGEELLTPTRIYVKQVLSVLESHE 240 Query: 241 VKGMAHITGGGFIENIPRVLPEGVNVDINYGSWPVLPIFDLLQKKGGVSNRDMFTTFNMG 300 VK + HITGGGF ENIPRVLPEG+ IN GSWPVLPIF+L+Q G +S DM+ TFNMG Sbjct: 241 VKALVHITGGGFTENIPRVLPEGMQAVINVGSWPVLPIFELVQGAGNISYPDMYKTFNMG 300 Query: 301 VGLVLVVAEADGXXXXXXXXXXXXXXXXIGRVTEGERIVTFTGAE 345 +G++LVV D IG + GER V + G E Sbjct: 301 IGMMLVVKPEDAVSVMEKLQELGEQAYLIGNIQAGERKVVYNGVE 345 >C5D4I2.1 C5D4I2_9BACI Phosphoribosylformylglycinamidine cyclo-ligase EC=6.3.3.1 Length = 346 Score = 431 bits (1108), Expect = e-119, Method: Compositional matrix adjust. Identities = 212/343 (61%), Positives = 261/343 (76%), Gaps = 1/343 (0%) Query: 1 VSEAYKNAGVDIAAGNEAVERMKKHVKRTFRPEVMTELGGFGALFGLNKDKYEEPVLVSG 60 ++EAYK AGVDI AG +AV MK+HV++T RPEV++ LGGFG +F L+ Y EPVL+SG Sbjct: 1 MAEAYKQAGVDIEAGYKAVSLMKQHVQKTMRPEVLSGLGGFGGMFDLSSLGYREPVLISG 60 Query: 61 TDGVGTKLKIAFAADRHDTIGIDAVAMCVNDIVVQGAEPLFFLDYLACDKVVPEKIEAIV 120 TDGVGTKLKIAF D HDTIGID VAMCVNDIVVQGAEPLFFLDY+AC K +PEKI IV Sbjct: 61 TDGVGTKLKIAFMMDCHDTIGIDCVAMCVNDIVVQGAEPLFFLDYIACGKAIPEKIAQIV 120 Query: 121 AGIAEGCHQAGCALIGGETAEMPGMYSAGEYDIAGFTVGVADKAKLVTGADIAPGDTVIG 180 GIA+GC +AGCALIGGETAEMPGMY EYD+AGF VG+A+K+KLVTG+ I GD +IG Sbjct: 121 KGIADGCVEAGCALIGGETAEMPGMYDENEYDVAGFAVGIAEKSKLVTGSAIQAGDALIG 180 Query: 181 LASSGVHSNGFSLVRKLLLEEDGYGLNDVVPELGAPLVDVLLAPTKIYVKPLLGLLEQLP 240 LAS+G+HSNG+SLVR+++ E+ L+ V L PL + LL PT+IYVKPLL +++Q Sbjct: 181 LASNGIHSNGYSLVRRIVFEQAKLALDRVYEPLSVPLGEELLKPTRIYVKPLLNVMKQFE 240 Query: 241 VKGMAHITGGGFIENIPRVLPEGVNVDINYGSWPVLPIFDLLQKKGGVSNRDMFTTFNMG 300 +KGMAHITGGGFIENIPR+LP+G+ +I+YGSWP+ P+FDLLQ+KG + DMF+ FNMG Sbjct: 241 IKGMAHITGGGFIENIPRMLPKGLGAEIDYGSWPIPPVFDLLQEKGNLLRHDMFSIFNMG 300 Query: 301 VGLVLVVAEADGXXXXXXXXXXXXXXXXIGRVTEGERIVTFTG 343 +G+VL V IGRV +GE V+F G Sbjct: 301 IGMVLAVDSEMIHPVIARLEELGEKAYLIGRVKQGEG-VSFAG 342 >Q4MHX5.1 Q4MHX5_BACCE Phosphoribosylformylglycinamidine cyclo-ligase EC=6.3.3.1 Length = 346 Score = 409 bits (1050), Expect = e-112, Method: Compositional matrix adjust. Identities = 218/343 (63%), Positives = 253/343 (73%), Gaps = 1/343 (0%) Query: 1 VSEAYKNAGVDIAAGNEAVERMKKHVKRTFRPEVMTELGGFGALFGLNKDKYEEPVLVSG 60 ++ AYK AGVDI AG EAV RMKKHV+ T R EV+ LGGFG +F L+K EEPVLVSG Sbjct: 1 MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSG 60 Query: 61 TDGVGTKLKIAFAADRHDTIGIDAVAMCVNDIVVQGAEPLFFLDYLACDKVVPEKIEAIV 120 TDGVGTKL +AF AD+HDTIGIDAVAMCVNDIVVQGAEPLFFLDY+AC K P KIE IV Sbjct: 61 TDGVGTKLMLAFMADKHDTIGIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIV 120 Query: 121 AGIAEGCHQAGCALIGGETAEMPGMYSAGEYDIAGFTVGVADKAKLVTGADIAPGDTVIG 180 GI+EGC QAGCALIGGETAEMPGMYS EYD+AGFTVG+ DK K+VTG I G +IG Sbjct: 121 KGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGIVDKKKIVTGEKIEAGHVLIG 180 Query: 181 LASSGVHSNGFSLVRKLLLEEDGYGLNDVVPELGAPLVDVLLAPTKIYVKPLLGLLEQLP 240 LASSG+HSNG+SLVRK+LLE+ LN + L PL + LL PTKIYVKP+L LL++ Sbjct: 181 LASSGIHSNGYSLVRKVLLEDGELSLNRIYGRLELPLGEELLKPTKIYVKPILELLKKYE 240 Query: 241 VKGMAHITGGGFIENIPRVLPEGVNVDINYGSWPVLPIFDLLQKKGGVSNRDMFTTFNMG 300 V GMAHITGGGFIENIPR+LPEG+ +I GSW + PIF LLQ+ G + ++MF FNMG Sbjct: 241 VYGMAHITGGGFIENIPRMLPEGIGAEIELGSWEIQPIFSLLQEVGKLEEKEMFNIFNMG 300 Query: 301 VGLVLVVAEADGXXXXXXXXXXXXXXXXIGRVTEGERIVTFTG 343 +G+V+ V E D IGR +G VTF G Sbjct: 301 IGMVVAVKEEDAKDIVRLLEEQGETARIIGRTVQGAG-VTFNG 342 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.319 0.140 0.409 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,084,662,086 Number of extensions: 95890507 Number of successful extensions: 217680 Number of sequences better than 1.0e-05: 1692 Number of HSP's gapped: 214542 Number of HSP's successfully gapped: 1710 Length of query: 346 Length of database: 3,060,696,203 Length adjustment: 136 Effective length of query: 210 Effective length of database: 1,779,438,163 Effective search space: 373682014230 Effective search space used: 373682014230 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 131 (55.1 bits)