BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0417.0002.p (505 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B1D6H8.1 B1D6H8_9BACL MMPL domain protein 628 e-178 A1SIP5.1 A1SIP5_NOCSJ MMPL domain protein 582 e-164 C5BVU1.1 C5BVU1_9MICO MMPL domain protein 520 e-145 A4AL12.1 A4AL12_9ACTN Putative membrane transport protein 477 e-133 A3Q809.1 A3Q809_MYCSJ MMPL domain protein 465 e-129 >B1D6H8.1 B1D6H8_9BACL MMPL domain protein Length = 794 Score = 628 bits (1620), Expect = e-178, Method: Compositional matrix adjust. Identities = 321/498 (64%), Positives = 372/498 (74%) Query: 1 MNDITPILAVMIGLAVGIDYSLFIVNRQRRLILDEKLSAREAASRAVGTAGSAVFFAGLT 60 M DITP LA+M+GLAVGIDYSLFIVNRQRR+ILD+ LSAREAASRAVGTAGSAVFFAGLT Sbjct: 277 MTDITPALAMMVGLAVGIDYSLFIVNRQRRMILDQGLSAREAASRAVGTAGSAVFFAGLT 336 Query: 61 VIIALCGMLVIGIGFLSTMXXXXXXXXXXXXXXXXXXXXXXXXXXGERICTAKARTKKAA 120 VIIALCGM+V+ I FL+ M GERI + KAR K Sbjct: 337 VIIALCGMVVMNIDFLTAMALVAAASVFINVLVALTLLPALLGLVGERIVSEKARKKNNE 396 Query: 121 SGNNAHHGFSHRWANATVKYRWXXXXXXXXXXGTAAIPVTKMELGIPSGASANLDTPARQ 180 + G +HRWAN V+ RW G AAIP +M+LG+PSG +ANLDTP RQ Sbjct: 397 QAGVSRQGTAHRWANGVVRRRWLVIVGVIVILGAAAIPAAQMKLGMPSGDTANLDTPTRQ 456 Query: 181 SYDIISKGFGEGFNGPLLLVAEPKNPSGKISLETLGKLVQGLQMHDNVTLVSPMGVNATG 240 SYD IS GFGEG+N PLLLVAEP + KI+ E LGKLVQ +Q H++V LV+PMG+N TG Sbjct: 457 SYDAISAGFGEGYNSPLLLVAEPASSGEKITPEVLGKLVQDIQQHEDVALVNPMGINQTG 516 Query: 241 DIAIISLIPKTGPTDTETRELVQELRDPASSLASGNELTLGVTGFTAINIDMSSKLSDAF 300 DI IIS+IPK+GPTD T +LVQ+LRD SS++ N++TLGVTGFTAINIDMS+KL++ F Sbjct: 517 DIGIISVIPKSGPTDKATNDLVQDLRDHNSSISQSNKVTLGVTGFTAINIDMSAKLAEVF 576 Query: 301 PXXXXXXXXXXXXXXXXXXXXXXXPIKATVGFILSVLATFGLTTAVYQWGWLHSLFGFDT 360 P P+KAT+GF+LS+LATFG+TTAV+QWGWLH LFGFDT Sbjct: 577 PLYIGIILILSLIILLLVFRSIIVPVKATIGFLLSILATFGITTAVFQWGWLHDLFGFDT 636 Query: 361 GGPLLSFMPILVTGILYGLAMDYQVFLVSSMREAYVHGRHGKESVVHGYDLASRVVLAAG 420 GGPLLSFMPI+V+GILYGLAMDYQVFLVSSMREAYVHG G SVV GY ASRVV+AA Sbjct: 637 GGPLLSFMPIMVSGILYGLAMDYQVFLVSSMREAYVHGHKGSSSVVEGYQQASRVVVAAA 696 Query: 421 IIMVSVFAGFIFAPDAMIKQIGFALAFGILIDAFIIRMTLVPAVMAVFGDKAWWLPKWLD 480 +IMVSVFAGFI D M+KQIGFAL GILIDAF +RM LVPA+MAVFGDKAW +PKWLD Sbjct: 697 VIMVSVFAGFILTEDIMLKQIGFALTIGILIDAFFVRMALVPAIMAVFGDKAWGMPKWLD 756 Query: 481 RLLPNLDVEGDKLIAKLH 498 R+LPNLDVEGDKLIA+L+ Sbjct: 757 RILPNLDVEGDKLIAELN 774 >A1SIP5.1 A1SIP5_NOCSJ MMPL domain protein Length = 784 Score = 582 bits (1499), Expect = e-164, Method: Compositional matrix adjust. Identities = 284/505 (56%), Positives = 356/505 (70%) Query: 1 MNDITPILAVMIGLAVGIDYSLFIVNRQRRLILDEKLSAREAASRAVGTAGSAVFFAGLT 60 MN TP+L +M+GLAVGIDY+LF+VNRQRRLILD+ L+A+EAA RAVGTAGSAVFFAGLT Sbjct: 271 MNSATPVLGLMVGLAVGIDYALFVVNRQRRLILDQGLTAQEAAGRAVGTAGSAVFFAGLT 330 Query: 61 VIIALCGMLVIGIGFLSTMXXXXXXXXXXXXXXXXXXXXXXXXXXGERICTAKARTKKAA 120 V+IAL + VIGI LSTM GERIC+ KAR ++ Sbjct: 331 VLIALTALTVIGIAVLSTMALVAASTVALAVLIALSLLPALLGLVGERICSDKARARRRT 390 Query: 121 SGNNAHHGFSHRWANATVKYRWXXXXXXXXXXGTAAIPVTKMELGIPSGASANLDTPARQ 180 HG + W +++RW G AIP M LGIPSGA+AN DT ARQ Sbjct: 391 KVEAESHGVADHWVKGVIRFRWPVIAGVVAILGVMAIPAASMHLGIPSGATANQDTAARQ 450 Query: 181 SYDIISKGFGEGFNGPLLLVAEPKNPSGKISLETLGKLVQGLQMHDNVTLVSPMGVNATG 240 SY+ +S+GFGEGFNGPLL+ AEP SG+++ E KL+ Q ++ L +P+GVN G Sbjct: 451 SYEAVSQGFGEGFNGPLLVTAEPVGTSGRVTPELTAKLIGEFQDRGDIVLAAPVGVNEAG 510 Query: 241 DIAIISLIPKTGPTDTETRELVQELRDPASSLASGNELTLGVTGFTAINIDMSSKLSDAF 300 D+A+ S+IP +GP D T +LV+ LR+P +++A N++ LGVTGFTAI IDMS K++ Sbjct: 511 DLAVFSIIPASGPDDEATSDLVKSLREPGNAIAQRNQVQLGVTGFTAIRIDMSDKIAGVL 570 Query: 301 PXXXXXXXXXXXXXXXXXXXXXXXPIKATVGFILSVLATFGLTTAVYQWGWLHSLFGFDT 360 P PIKAT GF+LS+LATFG TTAV+QWGWL LFGFDT Sbjct: 571 PLYLGIIIILSILILMLVFRSVVVPIKATAGFLLSILATFGATTAVFQWGWLSGLFGFDT 630 Query: 361 GGPLLSFMPILVTGILYGLAMDYQVFLVSSMREAYVHGRHGKESVVHGYDLASRVVLAAG 420 GGPL+SFMPI+VTGILYGLAMDY+VFLVSSMREA++HG+ ++SVVHG+D ASRVV+AA Sbjct: 631 GGPLMSFMPIIVTGILYGLAMDYEVFLVSSMREAHIHGQAARQSVVHGFDQASRVVVAAA 690 Query: 421 IIMVSVFAGFIFAPDAMIKQIGFALAFGILIDAFIIRMTLVPAVMAVFGDKAWWLPKWLD 480 IIMV+VF+GFIF+ D MIKQIGFALA GILIDAF++R+TLVPA+MA F ++AWWLP+WLD Sbjct: 691 IIMVAVFSGFIFSHDIMIKQIGFALAAGILIDAFLVRLTLVPALMAAFDERAWWLPRWLD 750 Query: 481 RLLPNLDVEGDKLIAKLHAEGGDTK 505 LLP+LD+EGDKL+A L+ + T Sbjct: 751 HLLPDLDIEGDKLLAMLNQQAEPTD 775 >C5BVU1.1 C5BVU1_9MICO MMPL domain protein Length = 779 Score = 520 bits (1339), Expect = e-145, Method: Compositional matrix adjust. Identities = 270/512 (52%), Positives = 342/512 (66%), Gaps = 12/512 (2%) Query: 1 MNDITPILAVMIGLAVGIDYSLFIVNRQRRLILDEKLSAREAASRAVGTAGSAVFFAGLT 60 M +TPILA+MIGLAVGIDY+LFIVNRQRRLILD+ LSA EAA RA+GTAGSAVFFAGLT Sbjct: 267 MMSMTPILALMIGLAVGIDYALFIVNRQRRLILDQGLSAHEAAGRALGTAGSAVFFAGLT 326 Query: 61 VIIALCGMLVIGIGFLSTMXXXXXXXXXXXXXXXXXXXXXXXXXXGERICTAKARTKKAA 120 VI+AL G+ V+GI FL+TM GER+ +AK R K Sbjct: 327 VIVALTGLSVVGISFLTTMALIAAATVLVAVLVALTLLPAILGFVGERVVSAKQREKAVG 386 Query: 121 SGNNAHHGFSHRWANATVKYRWXXXXXXXXXXGTAAIPVTKMELGIPSGASANLDTPARQ 180 + F+ RWA+ +++ G A+P M L +P+ A+AN DT RQ Sbjct: 387 HRHAERTTFATRWASGIARHKVLVTIGTVVALGAIAVPFGSMNLNLPTAATANFDTVERQ 446 Query: 181 SYDIISKGFGEGFNGPLLLVAEPKNPSGKISLETLGKLVQGLQMHDNVTLVSPMGVNATG 240 SYD I++GFGEGFN PLL+VA +N I + T+G L + L D+V+ V P G++ G Sbjct: 447 SYDAITEGFGEGFNSPLLVVASSEN-GEPIDVATIGTLKEDLFALDDVSAVMPTGLSEDG 505 Query: 241 DIAIISLIPKTGPTDTETRELVQELRDPASSLASGNELTLGVTGFTAINIDMSSKLSDAF 300 A ++++P++GP D TR+LV+ +R +L + + + LGVTG AINID+S LSDA Sbjct: 506 ATATLTVVPESGPNDAATRDLVEAIR----ALDATDGVELGVTGEAAINIDISQVLSDAL 561 Query: 301 PXXXXXXXXXXXXXXXXXXXXXXXPIKATVGFILSVLATFGLTTAVYQWGWLHSLFGFDT 360 P+ AT+GF+LS+ AT G TTAV+QWGW LFGFDT Sbjct: 562 VPYLVVIVVLSLLILLLVFRSVFVPVTATLGFVLSIGATLGATTAVFQWGWARELFGFDT 621 Query: 361 GGPLLSFMPILVTGILYGLAMDYQVFLVSSMREAYVHGRHGKESVVHGYDLASRVVLAAG 420 GPLLSF+PI+VTGILYGLAMDYQ+FLVSSMRE++VHG G + VVHGY +ASRVV+AA Sbjct: 622 PGPLLSFLPIIVTGILYGLAMDYQMFLVSSMRESHVHGHPGVKGVVHGYAMASRVVVAAA 681 Query: 421 IIMVSVFAGFIFAPDAMIKQIGFALAFGILIDAFIIRMTLVPAVMAVFGDKAWWLPKWLD 480 IIM+SVFAGFIF+ DAMIKQIGFALA GIL DAF++RM L+PAVM++ G+KAWWLP+WL Sbjct: 682 IIMISVFAGFIFSHDAMIKQIGFALAIGILFDAFVVRMMLIPAVMSIAGEKAWWLPRWLG 741 Query: 481 RLLPNLDVEGDKLIAKL-------HAEGGDTK 505 R+LPNLDVEGD+L+ L HA GD + Sbjct: 742 RILPNLDVEGDRLVRSLEAADRGRHAAAGDDE 773 >A4AL12.1 A4AL12_9ACTN Putative membrane transport protein Length = 763 Score = 477 bits (1228), Expect = e-133, Method: Compositional matrix adjust. Identities = 255/497 (51%), Positives = 335/497 (67%), Gaps = 2/497 (0%) Query: 1 MNDITPILAVMIGLAVGIDYSLFIVNRQRRLILDEKLSAREAASRAVGTAGSAVFFAGLT 60 ++ +TP+LA+M+GLAVGIDYSLFIVNRQRRLILD KLSA +AA+RA GTAGSAVFFAGLT Sbjct: 261 LSAVTPVLALMVGLAVGIDYSLFIVNRQRRLILDSKLSAGDAAARATGTAGSAVFFAGLT 320 Query: 61 VIIALCGMLVIGIGFLSTMXXXXXXXXXXXXXXXXXXXXXXXXXXGERICTAKARTKKAA 120 V+IALCG+ V+GI L+TM GERI +A+AR K + Sbjct: 321 VLIALCGLSVVGIQLLTTMALVAAATVAVAIAIALTLVPALLGLVGERIVSARARLKSSG 380 Query: 121 SGNNAHHGFSHRWANATVKYRWXXXXXXXXXXGTAAIPVTKMELGIPSGASANLDTPARQ 180 + + +H +HR+ +A V++R G AIP T + LG+PS A+AN T R+ Sbjct: 381 AADE-NHPVAHRFVSAVVRFRLPAVLIVVAVLGALAIPATSLTLGLPSSATANTGTAERE 439 Query: 181 SYDIISKGFGEGFNGPLLLVAEPKNPSGKISLETLGKLVQGLQMHDNVTLVSPMGVNATG 240 SYD+ + GFGEGF+G L+L A + + KI +TL L L+ NV LV P G+N Sbjct: 440 SYDLTAAGFGEGFSGQLVLAATSEEGT-KIDDQTLADLSDELRALSNVDLVLPGGLNDDR 498 Query: 241 DIAIISLIPKTGPTDTETRELVQELRDPASSLASGNELTLGVTGFTAINIDMSSKLSDAF 300 AI+S++P +GP T +LV E+R A + LT+GVTG TAI +D+SS ++ A Sbjct: 499 TTAILSVVPTSGPASEATGDLVHEIRGLADEFSDRYGLTVGVTGQTAITLDISSAMAAAL 558 Query: 301 PXXXXXXXXXXXXXXXXXXXXXXXPIKATVGFILSVLATFGLTTAVYQWGWLHSLFGFDT 360 P PI+AT GF+ SVLAT G+ T V+Q GW ++ GFDT Sbjct: 559 PLYLTVIVVLSLIIMLLVFRSLLIPIQATAGFLFSVLATLGVLTLVFQEGWFSNVLGFDT 618 Query: 361 GGPLLSFMPILVTGILYGLAMDYQVFLVSSMREAYVHGRHGKESVVHGYDLASRVVLAAG 420 GP++SF+PILVTGILYGLAMDYQVFLVSSMRE++VHG G E++ G++ AS+VV+AA Sbjct: 619 PGPIVSFLPILVTGILYGLAMDYQVFLVSSMRESHVHGHRGHEAIERGFEHASKVVVAAA 678 Query: 421 IIMVSVFAGFIFAPDAMIKQIGFALAFGILIDAFIIRMTLVPAVMAVFGDKAWWLPKWLD 480 IIMV+VFAGF F D M+KQIG AL+ GIL+DAF+IRMTL PA++A+FG+++WW+P+WLD Sbjct: 679 IIMVAVFAGFAFNEDIMVKQIGVALSVGILLDAFLIRMTLTPALLALFGERSWWIPRWLD 738 Query: 481 RLLPNLDVEGDKLIAKL 497 RLLPNLD+EGDKL +L Sbjct: 739 RLLPNLDIEGDKLNKEL 755 >A3Q809.1 A3Q809_MYCSJ MMPL domain protein Length = 772 Score = 465 bits (1196), Expect = e-129, Method: Compositional matrix adjust. Identities = 242/500 (48%), Positives = 324/500 (64%), Gaps = 3/500 (0%) Query: 1 MNDITPILAVMIGLAVGIDYSLFIVNRQRRLILDEKLSAREAASRAVGTAGSAVFFAGLT 60 M +T +LA+M+GLAVGIDY++FIVNRQRRLILD LSA +AA+RA+GTAGSAV FAG+T Sbjct: 268 MQSMTAVLALMLGLAVGIDYAMFIVNRQRRLILDRGLSAADAAARAIGTAGSAVVFAGMT 327 Query: 61 VIIALCGMLVIGIGFLSTMXXXXXXXXXXXXXXXXXXXXXXXXXXGERICTAKARTKKAA 120 V+IAL + V+GI L+ M GERI + K R + Sbjct: 328 VVIALVALTVVGISLLTPMALAAAATVVVAVVAAITLLPALLGLVGERIASPKGR--HSV 385 Query: 121 SGNNAHHGFSHRWANATVKYRWXXXXXXXXXXGTAAIPVTKMELGIPSGASANLDTPARQ 180 S ++H F+ W A ++ R G A+P M LG+P G S N TP R+ Sbjct: 386 STEESNHRFASAWVGAILRNRVPAALAGLAVTGVIALPALSMTLGMPDGGSYNEGTPQRE 445 Query: 181 SYDIISKGFGEGFNGPLLLVAEPKNPSGKISLETLGKLVQGLQMHDNVTLVSPMGVNATG 240 SYD+I++ +G+G+NGPL++VAEP +G+++ + L+ V V+ GVN Sbjct: 446 SYDVIAEHYGDGYNGPLVVVAEPTT-AGQLTPADIAATYSDLRRVPGVADVTFGGVNDAS 504 Query: 241 DIAIISLIPKTGPTDTETRELVQELRDPASSLASGNELTLGVTGFTAINIDMSSKLSDAF 300 D A+ S++P+ GPT+ T +LV+++R + LA E+ LGVTG TA+ IDMS +L A Sbjct: 505 DTAVFSVVPENGPTEEATAQLVRDIRAQSGPLAELREVKLGVTGITAMGIDMSDRLGKAI 564 Query: 301 PXXXXXXXXXXXXXXXXXXXXXXXPIKATVGFILSVLATFGLTTAVYQWGWLHSLFGFDT 360 P P+KAT GF+L+VLATFG TTA++QWGW L G Sbjct: 565 PVYVGIVMGLSILVLMVVFRSIAVPLKATAGFLLTVLATFGATTALFQWGWFQQLIGLSA 624 Query: 361 GGPLLSFMPILVTGILYGLAMDYQVFLVSSMREAYVHGRHGKESVVHGYDLASRVVLAAG 420 GP+LS +PI+V G+LYGLAMDY+VFLVSSM+EA+VHG G +V HG+ ASRVV+AA Sbjct: 625 TGPILSMLPIMVIGVLYGLAMDYEVFLVSSMKEAHVHGHRGDAAVAHGFTQASRVVVAAA 684 Query: 421 IIMVSVFAGFIFAPDAMIKQIGFALAFGILIDAFIIRMTLVPAVMAVFGDKAWWLPKWLD 480 +IM++VFAGF+F D MIKQ+GFALAFG+LIDAF++RMT+VPAVM++ GD+AWWLPK L Sbjct: 685 LIMMAVFAGFVFNADPMIKQMGFALAFGVLIDAFVVRMTVVPAVMSMLGDRAWWLPKRLA 744 Query: 481 RLLPNLDVEGDKLIAKLHAE 500 R+LP+LD+EGDKL L AE Sbjct: 745 RVLPDLDIEGDKLNRNLEAE 764 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.322 0.138 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,572,511,271 Number of extensions: 96935063 Number of successful extensions: 270588 Number of sequences better than 1.0e-05: 931 Number of HSP's gapped: 268753 Number of HSP's successfully gapped: 1053 Length of query: 505 Length of database: 3,060,696,203 Length adjustment: 140 Effective length of query: 365 Effective length of database: 1,741,754,103 Effective search space: 635740247595 Effective search space used: 635740247595 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 133 (55.8 bits)