BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0397.0020.p (614 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B1DAE2.1 B1DAE2_9BACL Histidine kinase internal region 209 6e-52 Q9K7B9.1 Q9K7B9_BACHD Two-component sensor histidine kinase 202 1e-49 B3K9S6.1 B3K9S6_9BACI Histidine kinase internal region 192 1e-46 B3KA48.1 B3KA48_9BACI Histidine kinase internal region 189 6e-46 B1DGU0.1 B1DGU0_9BACL Histidine kinase internal region 188 1e-45 >B1DAE2.1 B1DAE2_9BACL Histidine kinase internal region Length = 627 Score = 209 bits (533), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 163/621 (26%), Positives = 288/621 (46%), Gaps = 42/621 (6%) Query: 9 NNLTYQSKLLLAFFLLGIIPSIVIGTMAYFKSVDTLESRVNEDLGVIAGQLNEAIQRQVE 68 NN + + KL+L F L+ I+PS+VIG + + +E +VN + +N+++ Sbjct: 13 NNWSIRYKLILHFLLISILPSLVIGLLMGWIVNGIVEKQVNGHTMQLIDNVNKSLDYYAG 72 Query: 69 DVDRFSTFPYFTPEIFQILNQPYIPRDQWGYRELETQLQFAKLLVTYPSIFSTIQGLIFY 128 ++ S F P+I Q ++ + + + + +K L + S++S + G+I Sbjct: 73 NIQNISYFISMNPDI-----QAFLSEGKEAIDDDHEEYRMSKFLQGFTSLYSEVAGIIVV 127 Query: 129 STKGNVYGYRVSDRSSINESVSPVEEEWYKETLSRDGGVFISGLRQEKQF----NSAPFA 184 G+ + + R+ N+S++ +E WY+E + G I G + N Sbjct: 128 RPNGDYFSNEMYART--NDSLA--KESWYQEAVEAKGIFKIIGHPANRNVTTHSNYKDSE 183 Query: 185 TITASRLLLNDDFSPA-GVVAVDIRPDFMDKIVRSFQL-KSMHVMVADEKGELIYSTRTA 242 ++ R + + D GVV +D++ + + VR +L KS ++MV D+KGE IY+ + Sbjct: 184 VVSVVRAIQDPDTQKTLGVVLIDLKLRVIAETVRDVRLGKSGYLMVIDDKGESIYAPK-- 241 Query: 243 DNQRFLSAAAQQSGRNGATRGLITVPELGDGLEAATGVYAHSEYLGWTSYLLIDRKELLE 302 N + S GR G+ G L+ +Y S + WT+ + ++ ++ Sbjct: 242 -NSKIGSLGVALPGRQ--VSGMFAQTVGGQKLQF---IYQKSSFTNWTTVGVFAVQDSVQ 295 Query: 303 DANVIRNFTIVLVVIFTXXXXXXXXXXXXXXSKPIRSLISSMRDVERGLFVAPAAPPIKG 362 + I + + V I S+PI L S MR VE G + Sbjct: 296 EIKDINLYLVTFVFIVCMLGIAASYYLSHSISRPISQLASFMRKVEEGNMSIRIPEERED 355 Query: 363 EIGQLHLSYVTMVKRLDMLIQSIEENERQKREAELYALRARIAPHFLYNTINSIRMLAVL 422 EIG L S+ M+ ++ LI + +R KREAEL +L+A I PHFLYNT+++I+ LA Sbjct: 356 EIGLLGRSFNKMLSQMTRLISQVWAEQRLKREAELRSLQAHIQPHFLYNTLDTIQWLARK 415 Query: 423 QQSDGIAKLLQSLNKLLHANMKLDSELVPXXXXXXXXRHYVRLMELRYTNRFQVDWKIEE 482 + +++++L+KL + E++P R Y+++ + RY ++ + +++ Sbjct: 416 DGAKEATEMVEALSKLFRIGLSKGQEMIPLTDEIEHIRSYLKIQQTRYKDKLNYNIEVDG 475 Query: 483 HTERAMVPPMILQPLMENAIFHGSFEVEGPLLIEVQVSFVNNGGELLITIADNGHGITPE 542 + V +ILQPL+ENAI+HG E GP +I ++ EL+I D+G G+T Sbjct: 476 SCDDLFVLKLILQPLVENAIYHGIKERRGPGMITIRAIISEEILELVIQ--DDGAGMTEA 533 Query: 543 ALNVLNGLSPQNAAGHLSN-----------------SIGVANVRDRIRLRFGPPYTLLLV 585 L L + + H +N S G+ NV++RIRL FG Y + + Sbjct: 534 RLEALRAVLQAVPSVHEANAAQRAAEERQQGQGQAASYGLRNVQERIRLSFGETYGIAIA 593 Query: 586 SEPDRGTRAELYLPFKQEDGE 606 S+ GT + P G+ Sbjct: 594 SKEKAGTTVIIKHPIIHRKGQ 614 >Q9K7B9.1 Q9K7B9_BACHD Two-component sensor histidine kinase Length = 602 Score = 202 bits (513), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 162/611 (26%), Positives = 296/611 (48%), Gaps = 37/611 (6%) Query: 5 MRRWNNLTYQSKLLLAFFLLGIIPSIVIGTMAYFKSVDTLESRVNEDLGVIAGQLNEAIQ 64 + + N+L + KL++ F L+ I+PS+++ + + +E +VNE+ + ++N I+ Sbjct: 4 LAKLNSLPIRFKLVIHFLLISILPSLLLAVLVGWAVDRIIEQQVNENTLQLIDKVNSTIE 63 Query: 65 RQVEDVDRFSTFPYFTPEIFQILNQPYIPRDQWGYRELETQLQFAKLLVTYPSIFSTIQG 124 +E+V + F I Q L+ + G E + + +K L + +++ I G Sbjct: 64 AHIENVQNMTYFISLHSNIQQFLDGTL---EHLGPDE---EYEISKFLQNFTTLYPEIAG 117 Query: 125 LIFYSTKGNVYGYRVSDRSSINESVSPVEEEWYKETLSRDGGVFISGLRQEKQFNSAPF- 183 ++ + +G+ + RSS N + +E WY++ + G + G Q ++ S Sbjct: 118 ILVVNQQGDYLSNELYTRSSFNLN----QESWYRQAVENKGIAKLIGKPQGRRITSHVHY 173 Query: 184 ---ATITASRLLLNDDFSP-AGVVAVDIRPDFMDKIVRSFQL-KSMHVMVADEKGELIYS 238 +T R +++ GV+ +D++ +++ VR +L KS ++MV D+KG+ IYS Sbjct: 174 REDEVVTVVRAIIDSTTGEEKGVILIDLKLRVIEEAVRDVRLGKSGYLMVVDQKGDPIYS 233 Query: 239 TRTADNQRFLSAAAQQS--GRNGATRGLITVPELGDGLEAATGVYAHSEYLGWTSYLLID 296 S +QS R G+ T G+ + +Y S + GWT + Sbjct: 234 PAP-------SIMYEQSFDHRFSQNYGIFTEEVEGERYQL---MYQQSAFTGWTLIGVFS 283 Query: 297 RKELLEDANVIRNFTIVLVVIFTXXXXXXXXXXXXXXSKPIRSLISSMRDVERGLFVAPA 356 + +E+ I + + V S+PI L+ +M+ E G + Sbjct: 284 TDQSVEEVQQILFYVVTFVFFVCFVGITASYFLSYTISRPINQLMLAMQKAESGDLTSRY 343 Query: 357 APPIKGEIGQLHLSYVTMVKRLDMLIQSIEENERQKREAELYALRARIAPHFLYNTINSI 416 + E+G+L S+ TM++++ LI E ER+KREAEL++L+A I PHFLYNT+++I Sbjct: 344 EGEEQDEVGRLGRSFNTMIEQIGKLISLTERQERKKREAELHSLQANIKPHFLYNTLDTI 403 Query: 417 RMLAVLQQSDGIAKLLQSLNKLLHANMKLDSELVPXXXXXXXXRHYVRLMELRYTNRFQV 476 + +A + + +A L+ +L+KL + ++P ++Y+++ +RY N+ Sbjct: 404 QWMARKKNASDVADLVGALSKLFRIGLSKGGTIIPLVDEIEHIKNYLQIQSVRYKNKLNY 463 Query: 477 DWKIEEHTERAMVPPMILQPLMENAIFHGSFEVEGPLLIEVQVSFVNNGGELLITIADNG 536 + + ER + ++LQP++ENAI+HG E GP LI ++ N+ L+I I DNG Sbjct: 464 SLVMPSNMERLSILKIVLQPIVENAIYHGIKERRGPGLITIEAEREND--MLIIRIRDNG 521 Query: 537 HGITPEAL-------NVLNGLSPQNAAGHLSNSIGVANVRDRIRLRFGPPYTLLLVSEPD 589 GI PE L N+ + L+ G+ NV R+RL FG PY + + S + Sbjct: 522 KGIKPETLQQLRTNVNLFLEKGDKEGGQRLTKGYGLINVHARLRLTFGEPYGVKIDSVFN 581 Query: 590 RGTRAELYLPF 600 GT ++ P Sbjct: 582 EGTVVTIFHPI 592 >B3K9S6.1 B3K9S6_9BACI Histidine kinase internal region Length = 647 Score = 192 bits (487), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 154/626 (24%), Positives = 287/626 (45%), Gaps = 47/626 (7%) Query: 7 RWNNLTYQSKLLLAFFLLGIIPSIVIGTMAYFKSVDTLESRVNEDLGVIAGQLNEAIQRQ 66 R+ +L + KL++ F ++GI+PSI +G + + ++ +V + + G++N+ + Sbjct: 21 RFGDLPLRYKLVILFLMVGILPSIALGVLVNWTVNRIVDQQVTSNTIQLIGKVNQTLDND 80 Query: 67 VEDVDRFSTFPYFTPEIFQIL------NQP----------YIPRDQWGYRELETQLQFAK 110 +E++ + F P + L ++P Y P+ ++ E + + Sbjct: 81 MENLQNITYLIGFDPRTERFLQGDIQGDKPAAGADVPSGTYRPQTSPVKQDNEENYEIKR 140 Query: 111 LLVTYPSIFSTIQGLIFYSTKGNVYGYRVSDRSSINESVSPVEEEWYKETLSRDGGVFIS 170 L + +++ I ++ + +G + RS N + EEEWY+E + +G + Sbjct: 141 YLQGFTTLYPEIASILLVNREGAYISNEMYARSPANLT----EEEWYREAVLNEGIFTVL 196 Query: 171 GLRQEK------QFNSAPFATITASRLLLNDDFSPAGVVAVDIRPDFMDKIVRSFQL-KS 223 G ++ + + ++ S + D G V +D++ + + VR L KS Sbjct: 197 GHPADRNVTTHVHYGNEELVSVVRS-FVDPDTREVTGAVLIDLKLRAVARAVRDVTLGKS 255 Query: 224 MHVMVADEKGELIYSTRTADNQRFLSAAAQQSGRNGATRGLITVPELGDGLEAATGVYAH 283 ++MVA+ G IY+ + + + S G + G+ L+ +Y Sbjct: 256 GYLMVAEAGGSSIYTPEDS-----IIPSIPPSWFPEEESGALIREVNGERLQL---IYGT 307 Query: 284 SEYLGWTSYLLIDRKELLEDANVIRNFTIVLVVIFTXXXXXXXXXXXXXXSKPIRSLISS 343 S + GW + + E + + IR + I + I S+PI L+S Sbjct: 308 SSFTGWRTIGVFPTSESVYEVREIRFYMICFLFIVCLFGVTASYTLSQSISRPIWQLMSF 367 Query: 344 MRDVERGLFVAPAAPPIKGEIGQLHLSYVTMVKRLDMLIQSIEENERQKREAELYALRAR 403 M+ E G + E+G L S+ M+ ++ L++ E ERQKREAEL +L+A Sbjct: 368 MQKAESGDLTIRYWGNRQDEVGMLGRSFNRMLLQIRKLMKLSELRERQKREAELRSLQAH 427 Query: 404 IAPHFLYNTINSIRMLAVLQQSDGIAKLLQSLNKLLHANMKLDSELVPXXXXXXXXRHYV 463 I PHFLYNT+++I +A + +D ++ L++SL++L + +++P Y+ Sbjct: 428 IKPHFLYNTLDTIHWMARKKGADDVSDLVESLSRLFRIGLSKGDDIIPMSDEWTHISSYL 487 Query: 464 RLMELRYTNRFQVDWKIEEHTERAMVPPMILQPLMENAIFHGSFEVEGPLLIEVQVSFVN 523 ++ + RY +R QV+ ++ ER V +ILQP++ENAI+HG GP I +Q + Sbjct: 488 QIQKTRYRDRLQVEMELSPEAERLHVLKLILQPMVENAIYHGIKARRGPGRIWIQAQVED 547 Query: 524 NGGELLITIADNGHGITPEALNVLNGL---------SPQNAAGHLSNSIGVANVRDRIRL 574 N L++ + D+G G+ E L L +P S S G+ NV+ RI+L Sbjct: 548 N--VLVLAVRDDGAGMPAERLEALRRQLADPVTAMEAPPEEGPGASRSYGMLNVQARIKL 605 Query: 575 RFGPPYTLLLVSEPDRGTRAELYLPF 600 FG Y +++ S + GT + P Sbjct: 606 TFGETYGIMIDSIENEGTTVRITHPL 631 >B3KA48.1 B3KA48_9BACI Histidine kinase internal region Length = 574 Score = 189 bits (481), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 154/600 (25%), Positives = 281/600 (46%), Gaps = 51/600 (8%) Query: 16 KLLLAFFLLGIIPSIVIGTMAYFKSVDTLESRVNEDLGVIAGQLNEAIQRQVEDVDRFST 75 K+LLA LL IP I +G ++Y+ + +E + N+ + + + ++ + ++ S Sbjct: 6 KILLAIILLVFIPVIALGGVSYYSFSEAMEKKSNDFYWISLLETDRKLKFALNEITTISN 65 Query: 76 FPYFTPEIFQILNQPYIPRDQWGYRELETQLQFAKLLVTYPSIFSTIQGLIFYSTKGNVY 135 + Q+L QP Y + Q L+ +P I S FYS +Y Sbjct: 66 SAITQQSVQQMLKQP-------EYAVTYERRQEINNLINHPMIAS----FAFYSNDRLMY 114 Query: 136 GYRVSDRSSINESVSPVEEEWYKETLSRDG-GVFISGLRQEKQFNSAPFATITASRLLLN 194 + + E ++ WY+ +G V++ + AP + SR++ Sbjct: 115 -----NTNGGMELQELRQQAWYEAVEKAEGRPVWVGPGENGSAADGAP--VLIQSRVI-K 166 Query: 195 DDFS--PAGVVAVDIRPDFMDKIV-RSFQLKSMHVMVADEKGELIYSTRTAD-NQR---- 246 D +S G V + ++PD +D++ + LK +++ +++G +++S +R Sbjct: 167 DYYSLEDIGTVVIYVKPDLLDQVFWEAATLKQGDILLVNQQGHIVFSKSGGHIGERTEFP 226 Query: 247 FLSAAAQQSGRN------GATRGLITVPELGDGLEAATGVYAHSEYLGWTSYLLIDRKEL 300 FLS + + +G+ + LIT Y+ S W + K + Sbjct: 227 FLSDSYKTNGKGYYIDQYAGEKSLIT--------------YSPSHNKDWFLVAITPSKLI 272 Query: 301 LEDANVIRNFTIVLVVIFTXXXXXXXXXXXXXXSKPIRSLISSMRDVERGLFVA-PAAPP 359 ++ IRN ++L +I + I S ++ M+ V++G+FV P+ Sbjct: 273 SAESVPIRNLALILGLISLVSAFLFDRFFVRRMVRSIISAVNGMKRVKQGIFVPIPSHNV 332 Query: 360 IKGEIGQLHLSYVTMVKRLDMLIQSIEENERQKREAELYALRARIAPHFLYNTINSIRML 419 + E L + M ++ LI +E + +K+EAEL AL A+I PHF+YN++ SI + Sbjct: 333 AEDETDLLIDGFNRMSTQIQELIGQVETEQARKKEAELQALVAQINPHFIYNSLESINSM 392 Query: 420 AVLQQSDGIAKLLQSLNKLLHANMKLDSELVPXXXXXXXXRHYVRLMELRYTNRFQVDWK 479 AVLQ + I+K++ SL KLL ++ EL+P +HY+R+ + R+ +F + Sbjct: 393 AVLQGNKDISKMVISLGKLLRISISEHHELIPLSMELEHVQHYMRIQKFRFEEKFDYGIE 452 Query: 480 IEEHTERAMVPPMILQPLMENAIFHGSFEVEGPLLIEVQVSFVNNGGELLITIADNGHGI 539 + + +I+QP++ENA++HG +E LI ++VS NG +++I + DNG G Sbjct: 453 LPNELRHYVTQKLIVQPIVENALYHGIEPMEESGLISIKVS--ENGEDIVIDVEDNGPGF 510 Query: 540 TPEALNVLNGLSPQNAAGHLSNSIGVANVRDRIRLRFGPPYTLLLVSEPDRGTRAELYLP 599 PE L L P + N +G+ NV +R+R+RFG Y L++ S P G+ + +P Sbjct: 511 DPETLMKLWNSDPGQLKKYRENGVGLKNVHERLRIRFGSRYGLMICSSPGYGSLIRIRIP 570 >B1DGU0.1 B1DGU0_9BACL Histidine kinase internal region Length = 605 Score = 188 bits (478), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 146/609 (23%), Positives = 288/609 (47%), Gaps = 40/609 (6%) Query: 10 NLTYQSKLLLAFFLLGIIPSIVIGTMAYFKSVDTLESRVNEDLGVIAGQLNEAIQRQVED 69 N+ +Q+KL+ + L +IP + + + + KS + LE E + Q+ + +++ Sbjct: 16 NMRFQNKLMAGYLLACVIPLLGVSALIFHKSAEGLEQSSQEFASLYTSQIRTTLNEFIDE 75 Query: 70 VDRFSTFPYFTPEIFQILNQPY-IPRDQWGYRELETQLQFAKLLVTYPSIFSTIQGLIFY 128 D+ + E+ L + + D+ + + Q ++ + P+I + I Sbjct: 76 YDKVTKSVLVDSEVISKLGEEQTLSMDELIIQRVAIQRLLMRITLLKPAIGTAI----LI 131 Query: 129 STKGNVYGYRVSDRSSINESVSPVEEEWYKETLSRDGGVFISGLRQEKQF-NSAPFATIT 187 S + NVY Y + S +NE + + +WYK+ S + FI+GL + + A +T Sbjct: 132 SKENNVYQYTTTT-SRVNEGM-LLSRDWYKQLRSSEDTFFITGLHDRSYYEDKGAGAVVT 189 Query: 188 ASRLLLNDDFSPAGVVAVDIRPDFMDKIVRSFQLK----SMHVMVADEKGELIYSTRTAD 243 R+L + D + AG++ +D+ P + ++ F L + V++++ + E++Y + A Sbjct: 190 VGRVLFSSDGAYAGMLLIDLDPFALLQLDPDFILARDKYGISVIISNREHEIVYHSDAAS 249 Query: 244 NQRFLSAAAQQSG----RNGATRGLITVPELGDGLEAATGVYAHSEYLGWTSYLLIDRKE 299 R SG ++ ++ G I + G + ++ +E I R + Sbjct: 250 G-RLSWEQVLDSGERYIQDDSSHGKIILT----GTTSREKLFIKTE---------IPRSK 295 Query: 300 LLEDANVIRNFTIVLVVIFTXXXXXXXXXXXXXXSKPIRSLISSMRDVERGLFVAPAAPP 359 LL+ N I+ T++ +++ +KPI++L M+ E G ++ Sbjct: 296 LLQKINQIKAMTVIAILMSCLVITLISLGLSYTITKPIKALRRRMKQAETGQYLPIERVQ 355 Query: 360 IKGEIGQLHLSYVTMVKRLDMLIQSIEENERQKREAELYALRARIAPHFLYNTINSIRML 419 EIG L SY M+ + LI+ + E ++R+A+L AL+ +I PH LYNT+ SIRM Sbjct: 356 SNDEIGSLVRSYNKMITTIGTLIEDVYIAEIKRRQAKLAALQNQINPHMLYNTLESIRMK 415 Query: 420 AVLQQSDGIAKLLQSLNKLLHANMKLDSELVPXXXXXXXXRHYVRLMELRYTNRFQVDWK 479 ++++ + A +++ L ++ + + +Y++L +R+ + F + K Sbjct: 416 SLMKDDEETADMIKILARMFRLTLGKEGRHHSVRHELEYTANYLQLQNIRFDDSFHLHIK 475 Query: 480 IEEHTERAMVPPMILQPLMENAIFHGSFEVEGPLLIEVQVSFVNNGGELLITIADNGHGI 539 + + + P++ QP++EN+I HG + PL IE++ + GE+LI I D+G GI Sbjct: 476 VPDEMLSCSIIPLVFQPIVENSINHGFEDYSRPLNIEIEGIWTEE-GEILIRITDDGAGI 534 Query: 540 TPEALNVLNGLSPQNAAG--HLSNS-------IGVANVRDRIRLRFGPPYTLLLVSEPDR 590 + L L + AG L+++ +G+ N+ +RI+L +G Y L + DR Sbjct: 535 SAGKHKELLHLLEEAGAGKHRLADAELPENEGLGLKNIAERIKLHYGERYYLTIRPGQDR 594 Query: 591 GTRAELYLP 599 GT E+ +P Sbjct: 595 GTIVEILIP 603 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.320 0.137 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,348,108,570 Number of extensions: 133888651 Number of successful extensions: 346986 Number of sequences better than 1.0e-05: 2115 Number of HSP's gapped: 343928 Number of HSP's successfully gapped: 2116 Length of query: 614 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 472 Effective length of database: 1,722,912,073 Effective search space: 813214498456 Effective search space used: 813214498456 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 134 (56.2 bits)