BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0385.0018.p (648 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3K5P4.1 B3K5P4_9BACI Histidine kinase internal region 683 0.0 B3KEQ4.1 B3KEQ4_9BACI Histidine kinase internal region 415 e-114 B1D7Q6.1 B1D7Q6_9BACL Histidine kinase internal region 259 5e-67 B1DAQ3.1 B1DAQ3_9BACL Histidine kinase internal region 209 9e-52 A6M1T7.1 A6M1T7_CLOB8 Histidine kinase internal region 193 6e-47 >B3K5P4.1 B3K5P4_9BACI Histidine kinase internal region Length = 602 Score = 683 bits (1762), Expect = 0.0, Method: Compositional matrix adjust. Identities = 322/583 (55%), Positives = 438/583 (75%) Query: 53 KWSERFYQVSIKQRVLISFIVLITLSISAMGVLTYRIAGKEIQNNAFDTSKETVDKTLQL 112 K+S+ Y ++ KQRV +SFI++ITL+I A+G+ TY IA KE+Q NAF++ +ETV+KT Q+ Sbjct: 13 KFSKWVYGITFKQRVRLSFIIMITLAIGAVGMTTYWIASKELQKNAFESRQETVNKTTQI 72 Query: 113 LDYRLNDVAMSVQSLMLSDAYRQMMIDVQAHDVTNYYVHLSEMQYVLSQATFNEPMIENV 172 LD +L ++ SV+SLM S A+++MM+DVQ++D++NYYVHLSE+QYV SQ TFNEP+IE++ Sbjct: 73 LDDKLAGISNSVRSLMFSYAFKEMMLDVQSNDISNYYVHLSELQYVFSQVTFNEPLIESI 132 Query: 173 LIATPIGDFYSTTQVRAQDNSFYGSELYDNSKKSPGGYWAKGHYDRLFTGSQRVVSFVVR 232 LIATPIGDFY +Q R+Q SFY S +Y + K++ GG W KGH D+ FTG+ R +SFV + Sbjct: 133 LIATPIGDFYPVSQRRSQTQSFYESSMYYDVKENYGGIWVKGHTDKFFTGNSRTLSFVTK 192 Query: 233 GIYENTPITNVFIVVNLRENKIASLLGQGTSGNDRKYLLLNTEGETVVQTGWPAKGEPPK 292 G EN TNVFIVVN+ E+ + ++ Q +S +D Y +++++GE V++T W + K Sbjct: 193 GTQENVSNTNVFIVVNVNESGLIGMVNQHSSNDDSDYFVIDSKGEEVIRTAWSSSHNLMK 252 Query: 293 DPEFLQDSTADSEGNFFYPFEGENYLVNYKQSAVAPNWILAGMQSKDQVLGQLKGVQRAV 352 D FL + ++G+FF+ F+ +YLVNY +SAV +W L G+Q KD++L Q+ GV+R Sbjct: 253 DKPFLYKVSEGNQGSFFHHFDETDYLVNYTRSAVVKDWSLFGIQQKDKLLEQMNGVKRTT 312 Query: 353 LYVILVFLLTTWFFSNKLTAALLRPLFKLSRLMRRVEENQLSVSFESKYNDEIAQVGFQF 412 Y++L FL+ TW S KLTA LL PL+KL RLMR VE+N+L+V F S+ DE+AQVG+QF Sbjct: 313 FYIMLFFLVLTWLLSTKLTAILLNPLYKLQRLMREVEDNRLNVRFASRSTDEVAQVGYQF 372 Query: 413 NRMMTEIKTLIEDVRQKEKDKRHAEIRALTAQMEPHFLYNTLNTIYCKSVMGENDDVNEM 472 NRM+ EI LI+DVR E KR AE+RALTAQMEPHFLYNTLNTIYCKSV+GEND+VNEM Sbjct: 373 NRMLDEINRLIDDVRLSESGKRKAEMRALTAQMEPHFLYNTLNTIYCKSVLGENDEVNEM 432 Query: 473 ILALSQMFQLGLGGGQDLITLEDELSHVQQYCAIQQKCYENLFEYHXXXXXXXXXSFPIP 532 IL+LSQMFQLGL GG+D TLEDEL HV+QYC +QQKCYE LFE+ + +P Sbjct: 433 ILSLSQMFQLGLSGGKDWNTLEDELLHVEQYCLLQQKCYEGLFEFEVTVTDDSLLTCLMP 492 Query: 533 KILLQPLVENSIQHGFSDRRSGGCIQVRISLEQSMLHIVVEDNGKGMDAAKVEQGMAKRE 592 KILLQP+VENSIQHGF D SGG I + + + +L++++EDNG GMDA V +GM + Sbjct: 493 KILLQPIVENSIQHGFRDIGSGGQIHLHVCRQGQLLYLIIEDNGIGMDADNVMKGMLEPP 552 Query: 593 ISKKGYALVNIRHRLQLYYGDEARMELSGQAGVGSRTDLWIPL 635 +SKKGYAL NI +RL L+YG++A ++L+ G GSRT++W+P+ Sbjct: 553 VSKKGYALNNIVNRLSLFYGEDAGIKLTSLPGKGSRTEIWMPI 595 >B3KEQ4.1 B3KEQ4_9BACI Histidine kinase internal region Length = 584 Score = 415 bits (1066), Expect = e-114, Method: Compositional matrix adjust. Identities = 219/576 (38%), Positives = 350/576 (60%), Gaps = 12/576 (2%) Query: 62 SIKQRVLISFIVLITLSISAMGVLTYRIAGKEIQNNAFDTSKETVDKTLQLLDYRLNDVA 121 S + ++ ++F+ +I LS+ G L+Y I+ ++ NA +++TV ++ Q++D +LN + Sbjct: 8 SFRNKLKVAFLAVIVLSVLMTGGLSYYISAATLEKNALKLTQDTVVRSAQIVDEKLNKLM 67 Query: 122 MSVQSLMLSDAYRQMMIDVQAHDVTNYYVHLSEMQYVLSQATFNEPMIENVLIATPIGDF 181 + + + M+S + M+ D + D + YY HL+++ V SQA EP+I+++ + TPIG+F Sbjct: 68 LIMMTFMISQPFYDMLKDAASGDASRYYTHLNDLDNVFSQARIAEPLIQSIYVFTPIGEF 127 Query: 182 YSTTQVRAQDNSFYGSELYDNSKKSPGGYWAKGHYDRLFTGSQRVVSFVVRGIYENTPIT 241 Y ++ R + +F + LY ++ W +GH D LF+G +RV+S ++ I+ +TP++ Sbjct: 128 YPSSMNRNRLTAFEDTVLYSRIEQEKKNLWVEGHEDMLFSGKERVISLILEPIF-DTPVS 186 Query: 242 NVFIVVNLRENKIASLLGQGTSGNDRKYLLLNTEGETVVQTGWPAKGEPPKDPEFLQDST 301 V+IVVN+RE+ L+ QG + LLN +G+TV +P K + D + Sbjct: 187 GVYIVVNIREDGFRKLV-QGNTAEGASSFLLNADGDTV----YPVKETLVRQAVETGDLS 241 Query: 302 A---DSEGNFFYPFEGENYLVNYKQSAVAPNWILAGMQSKDQVLGQLKGVQRAVLYVILV 358 SEG+ + +G+ YL+NY + +A +W + ++S+ VL + V+ + V L Sbjct: 242 GLMNRSEGSQPFDLDGQTYLLNYARLGIA-DWTMTTIRSRADVLHDMVYVKWLIAGVTLA 300 Query: 359 FLLTTWFFSNKLTAALLRPLFKLSRLMRRVEENQLSVSFESKYNDEIAQVGFQFNRMMTE 418 T S + LL+PL L ++M+RVE N L+ FES DE+AQVGF+FNRM+ + Sbjct: 301 AFTVTTLISGAFSRYLLKPLQGLLKVMKRVENNDLTARFESGSGDELAQVGFRFNRMLEQ 360 Query: 419 IKTLIEDVRQKEKDKRHAEIRALTAQMEPHFLYNTLNTIYCKSVMGENDDVNEMILALSQ 478 I LI++V + + KR AEI+AL+AQM+PHFLYNTLNTIY K + + + +M+++LS+ Sbjct: 361 IVVLIDEVTEAQTHKRTAEIKALSAQMDPHFLYNTLNTIYWKLKLKQIEPSQQMVMSLSR 420 Query: 479 MFQLGLGGGQDLITLEDELSHVQQYCAIQQKCYENLFEYHXXXXXXXXXSFPIPKILLQP 538 +FQLGL GQ++ T+ EL HV+QY +Q CYE+LF Y S IP+I+LQP Sbjct: 421 LFQLGLNNGQEITTMSKELEHVRQYLELQLSCYEDLFSYEIHVREPEVSSISIPRIILQP 480 Query: 539 LVENSIQHGFSDRRSGGCIQVRISLEQSMLHIVVEDNGKGMDAAKVEQGMAKREISKKGY 598 LVENSI HGF D ++GG I++ IS ++ I V DNG+GMD A+V + + E SKKGY Sbjct: 481 LVENSILHGFRDLKNGGLIEIEISGDEKRWTIAVRDNGRGMDEAQV-RALFWLE-SKKGY 538 Query: 599 ALVNIRHRLQLYYGDEARMELSGQAGVGSRTDLWIP 634 A+ N+ RL+LYYGD A + G+ + +P Sbjct: 539 AVSNLIRRLRLYYGDGAEFRVDSAPERGTEIRISLP 574 >B1D7Q6.1 B1D7Q6_9BACL Histidine kinase internal region Length = 284 Score = 259 bits (663), Expect = 5e-67, Method: Compositional matrix adjust. Identities = 134/256 (52%), Positives = 177/256 (69%), Gaps = 4/256 (1%) Query: 365 FFSNKLTAALLRPLFKLSRLMRRVEE-NQLSVSFESKYNDEIAQVGFQFNRMMTEIKTLI 423 +SN LTA LL+PL KL LM +VE N LSV FES+Y DE++QVG +FN M+ E+ I Sbjct: 2 IYSNILTAILLKPLLKLRNLMVKVEHSNDLSVRFESEYQDEVSQVGRKFNSMLEELALSI 61 Query: 424 EDVRQKEKDKRHAEIRALTAQMEPHFLYNTLNTIYCKSVMGENDDVNEMILALSQMFQLG 483 ++ + E KR AEI+AL AQ++PHFLYNTLNTIY K+ + ++D+V EM+L+LS+MFQLG Sbjct: 62 KETEEIEIKKRKAEIKALQAQIDPHFLYNTLNTIYWKAQLHQSDEVKEMVLSLSRMFQLG 121 Query: 484 LGGGQDLITLEDELSHVQQYCAIQQKCYENLFEYHXXXXXX--XXXSFPIPKILLQPLVE 541 L G D TLE E+ HV+QY IQ+KCY NLF+Y I K++LQPLVE Sbjct: 122 LNNGFDYTTLEKEIEHVKQYLFIQKKCYTNLFDYKVTIDLENDSIIDITILKVILQPLVE 181 Query: 542 NSIQHGFSDRRSGGCIQVRISLEQSMLHIVVEDNGKGMDAAKVEQGMAKREISKKGYALV 601 NSI HGF +R+SGG I + I + L I VEDNG+GM+ +++Q + + K GYAL Sbjct: 182 NSILHGFKNRKSGGLIHIWIRKTEEHLVITVEDNGEGMNVDEIKQSL-QVPTQKTGYALR 240 Query: 602 NIRHRLQLYYGDEARM 617 NI HRLQLYYG+++ M Sbjct: 241 NIYHRLQLYYGEDSEM 256 >B1DAQ3.1 B1DAQ3_9BACL Histidine kinase internal region Length = 601 Score = 209 bits (531), Expect = 9e-52, Method: Compositional matrix adjust. Identities = 162/625 (25%), Positives = 293/625 (46%), Gaps = 73/625 (11%) Query: 54 WSERFYQVSI--KQRVLISFIVLITLSISAMGVLTYRIAGKEIQNNAFDTSKETVDKTLQ 111 WS RF +++ + ++++SF ++I+L+ MG YR+ +E++ + + +++ Sbjct: 2 WS-RFLNLNMQFRNKMILSFFIVISLTAIIMGYSYYRMMSRELEASTLQGLERMTTQSVD 60 Query: 112 LLDYRLNDVAMSVQSLMLSDAYRQMMIDVQAHDVTNYYVHLSEMQYVLSQATFNEPMIEN 171 LD V+ ++ SD Q +D + Y + +I N Sbjct: 61 TLDLHFKTVS-NIGYSYFSDTSLQKFLDGPPNTDNEQY--------------YRNRIISN 105 Query: 172 VLIATPIGDFYSTTQVRAQDNSFY--------------GSELYDNSKKSPGG-YWAKGHY 216 L P+ F S T++ Q S Y + L+D S++ G +W H Sbjct: 106 KL-QNPLVSFISITRLDGQQISSYYYYNRSVKSLLDEEQASLFDKSRQMDGTPFWTVSHT 164 Query: 217 DRLFTGSQ-RVVSFV--VRGIYENTPITNVFIVVNLRENKIASLLGQGTSGNDRKYLLLN 273 T + + +S++ ++ I N +I +++ + + + + KY + + Sbjct: 165 TISTTVTPVKSISYIQLLKRITMNEQHPIGYIKIDIDPGVLDKIFPETQKSDAGKYYIAD 224 Query: 274 TEGETVV-----QTGWPAKGEP--------PKDPEFLQDSTADSEGNFFYPFEGENYLVN 320 G + G G P P+ +++ NF Y + + Y + Sbjct: 225 RSGHIIFARNKEDIGKSIAGSPLFAAYKKAPRSSDYV---------NFRYENQNKTY-IG 274 Query: 321 YKQSAVAPNWILAGMQSKDQVLGQLKGVQRAVLYVILVFLLTTWFFSNKLTAALLRPLFK 380 + + A +WI+ G DQVL ++ + ++ + ++ L ++ + A + RPL + Sbjct: 275 FYERLDAGDWIVIGNIPLDQVLSKVNSFRHTLIVIAMISFLAAMLIASLIAAGVTRPLKE 334 Query: 381 LSRLMRRVEENQLSVSFESKYNDEIAQVGFQFNRMMTEIKTLIEDVRQKEKDKRHAEIRA 440 L++ M++VE + E K DE++ + FN+M EI TLI V + E K+ AEI+A Sbjct: 335 LNKKMKQVEMGDFGATIEVKGKDELSTIQHSFNKMTAEISTLISKVYETELLKKEAEIKA 394 Query: 441 LTAQMEPHFLYNTLNTIYCKSVMGENDDVNEMILALSQMFQLGLGGGQDLITLEDELSHV 500 L Q+ PHFLYNTL+TI S + ++ V+ + +AL M + L GG L T+++E++H+ Sbjct: 395 LQTQINPHFLYNTLSTIDSISSIDGDERVSFICVALGSMLRYNLNGGS-LATVQEEITHL 453 Query: 501 QQYCAIQQKCYENLFEYHXXXXXXXXXSFPIPKILLQPLVENSIQHGFSDRRSGGCIQVR 560 QY +I Q + N+F Y +PK L+QPLVEN+I HG + ++V Sbjct: 454 NQYLSIYQIRFANVFAYE-IEVEPGIEDLILPKFLIQPLVENAIIHGLEQKVGSKKVRVT 512 Query: 561 I-SLEQSMLHIVVEDNGKGMDAAKVE---------QGMAKREISKKGY-ALVNIRHRLQL 609 + S+++S L I+VEDNG GMD A +E + R+ S + L N+ R+QL Sbjct: 513 LGSVDESFLKIIVEDNGVGMDPAMIELFHRKLSNPNAIVSRQTSSRTMIGLANVFKRIQL 572 Query: 610 YYGDEARMELSGQAGVGSRTDLWIP 634 YY + R+E+ Q G G++ +P Sbjct: 573 YYESDPRVEIYSQPGAGTKIYFELP 597 >A6M1T7.1 A6M1T7_CLOB8 Histidine kinase internal region Length = 589 Score = 193 bits (490), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 110/327 (33%), Positives = 185/327 (56%), Gaps = 7/327 (2%) Query: 314 GENYLVNYKQSAVAPNWILAGMQSKDQVLGQLKGVQRAVLYVILVFLLTTWFFSNKLTAA 373 GENY + K + W G+ + + L +K ++ V ++ L+ T + Sbjct: 261 GENYQLT-KIDSKYTGWETIGVFPESESLRVIKYIRYYSFVVAILALIIAEILVIIFTRS 319 Query: 374 LLRPLFKLSRLMRRVEENQLSVSFESKYNDEIAQVGFQFNRMMTEIKTLIEDVRQKEKDK 433 ++ P+ KL RLMR+ +E L+VSF +KYNDEI ++G FN M+ EI LI+ V+ +EK+K Sbjct: 320 IVNPIQKLKRLMRKAQEGDLTVSFNAKYNDEIGELGGSFNTMVKEINNLIKLVQIEEKNK 379 Query: 434 RHAEIRALTAQMEPHFLYNTLNTIYCKSVMGENDDVNEMILALSQMFQLGLGGGQDLITL 493 R AE+ L AQ++PHF+YNTL+TI + +D+ E+I A + + ++ L G+++I++ Sbjct: 380 RLAEMNVLQAQIKPHFMYNTLDTIRWMAEEHNEEDIVEIIEAFTNLLRISLSKGKEIISV 439 Query: 494 EDELSHVQQYCAIQQKCYENLFEYHXXXXXXXXXSFPIPKILLQPLVENSIQHGFSDRRS 553 ++ELSHVQ Y IQ+ YE+ +Y ++ + K++LQPLVEN+I HG ++R Sbjct: 440 KEELSHVQSYLIIQKIRYEDKLDYE-IQFDKEILNYKLIKLILQPLVENAIYHGIKEKRG 498 Query: 554 GGCIQVRISLEQSMLHIVVEDNGKGMDAAKVEQGMAKREI-----SKKGYALVNIRHRLQ 608 G I + +E ++L V DNGKGMD + + ++ GY + N+ R++ Sbjct: 499 NGKILITGKIEDNLLCFTVADNGKGMDEETLNKINNMLNNNDGNKNQIGYGIFNVNERIK 558 Query: 609 LYYGDEARMELSGQAGVGSRTDLWIPL 635 + +G E + G G+ +L P+ Sbjct: 559 IIHGSEYGLVYRSILGEGTIVELRHPI 585 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.319 0.135 0.393 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,690,384,836 Number of extensions: 149936341 Number of successful extensions: 413851 Number of sequences better than 1.0e-05: 2070 Number of HSP's gapped: 410717 Number of HSP's successfully gapped: 2070 Length of query: 648 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 506 Effective length of database: 1,722,912,073 Effective search space: 871793508938 Effective search space used: 871793508938 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 135 (56.6 bits)