BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0377.0028.p (377 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KKL1.1 B3KKL1_9BACI Dihydroorotase 486 e-135 C3ACH3.1 C3ACH3_BACMY Dihydroorotase 478 e-133 C2Q2I2.1 C2Q2I2_BACCE Dihydroorotase 478 e-133 B9J2E7.1 B9J2E7_BACCQ Adenine deaminase; dihydroorotase 477 e-133 Q3EP60.1 Q3EP60_BACTI Dihydroorotase 476 e-132 >B3KKL1.1 B3KKL1_9BACI Dihydroorotase Length = 370 Score = 486 bits (1252), Expect = e-135, Method: Compositional matrix adjust. Identities = 238/362 (65%), Positives = 283/362 (78%), Gaps = 1/362 (0%) Query: 17 VLRNLQLV-DGRTVDIAIRDGIISAITPAGRAEGKTMLDGSGLYVSSGWIDLHVHAVPEL 75 VLRN+Q V + + DI + +G I+ IT A A G DG+GLYVSSGWID+HVHAV +L Sbjct: 9 VLRNVQTVHNEKPFDIVMENGFITEITDANTASGDNGFDGTGLYVSSGWIDMHVHAVAKL 68 Query: 76 HPYGDDIDEIGVKQGVTTIVDAGSCGADRIGAFYAGSLLAATNVLAFLNISRIGLERTDE 135 PYGD IDEIGV+QGV TI+DAGSCG+D IG A A TNV AFLNIS IGL+R DE Sbjct: 69 EPYGDAIDEIGVQQGVATIIDAGSCGSDTIGELAAEVAKAKTNVFAFLNISHIGLQRIDE 128 Query: 136 LSQLEWIDRDEAVQAAAAYPDFIVGLKARISQSVVKENGIQPLKQARALSGETKLPLMVH 195 LS LEWID ++A +A YPD I+GLKARIS+SVVK+NG++PL+ AR LSG+T LPLMVH Sbjct: 129 LSSLEWIDPEKAAKAVLTYPDLIIGLKARISKSVVKDNGVEPLRLARKLSGKTSLPLMVH 188 Query: 196 IGSAPPEISEVLELLQPGDVITHYLNGKSNNLFHADGTPLQGLLEAVAKGVHLDVGHGTA 255 IGS PP I EVLELLQ D+ITHYLNGK+NNLF +DG P+ L EA+A+GVHLDVGHGTA Sbjct: 189 IGSGPPPIEEVLELLQKDDIITHYLNGKANNLFDSDGKPIPALTEAIARGVHLDVGHGTA 248 Query: 256 SFSFRIAGQAKKAGIPLNTISTDIYRGNRLNGPVYSMSNVLSKFLYLGYSLEEIIHAVTR 315 SFSF +A AK GI +TISTDIYRGNR++GPVYS++NV+SKFLYLGY L+E++ AVT Sbjct: 249 SFSFLVAEYAKAQGIKPDTISTDIYRGNRIHGPVYSLANVMSKFLYLGYGLQEVVAAVTD 308 Query: 316 NAALWLKRPELAGISVGQQANLTLFALEEGRKELTDSEGDVRVADHYIEAKGVFANGSLI 375 +AA WL RPEL I VG A+LTLFA+ +G LTDSEG+ R+AD YIEAKGV NGS I Sbjct: 309 HAAAWLGRPELGRIQVGDAAHLTLFAVRQGPMSLTDSEGETRIADRYIEAKGVVVNGSFI 368 Query: 376 TC 377 TC Sbjct: 369 TC 370 >C3ACH3.1 C3ACH3_BACMY Dihydroorotase Length = 366 Score = 478 bits (1231), Expect = e-133, Method: Compositional matrix adjust. Identities = 233/361 (64%), Positives = 276/361 (76%) Query: 17 VLRNLQLVDGRTVDIAIRDGIISAITPAGRAEGKTMLDGSGLYVSSGWIDLHVHAVPELH 76 VLRN++ V+G +DI + + I+ +T AG EG +LD SG YVSSGWIDLHVHA PE Sbjct: 6 VLRNVKRVNGEEIDIVVENNKIAQVTKAGAGEGGKVLDYSGTYVSSGWIDLHVHAFPEFD 65 Query: 77 PYGDDIDEIGVKQGVTTIVDAGSCGADRIGAFYAGSLLAATNVLAFLNISRIGLERTDEL 136 PYGD++DEIGVKQGVTTIVDAGSCGADRI A TN+ AFLNISRIGL+R DEL Sbjct: 66 PYGDEVDEIGVKQGVTTIVDAGSCGADRIADLVQSREQAKTNLFAFLNISRIGLKRIDEL 125 Query: 137 SQLEWIDRDEAVQAAAAYPDFIVGLKARISQSVVKENGIQPLKQARALSGETKLPLMVHI 196 S +EWID+++ + A Y D IVGLKAR+S+SVV ++GI+PL AR+LS ET LP+MVHI Sbjct: 126 SNMEWIDKEKVIDAVEKYKDVIVGLKARMSKSVVCDSGIEPLHVARSLSRETSLPIMVHI 185 Query: 197 GSAPPEISEVLELLQPGDVITHYLNGKSNNLFHADGTPLQGLLEAVAKGVHLDVGHGTAS 256 GSAPP I EV+ LL+ DVITHYLNGK NNLF +G PL LL+AV +GVHLDVGHG AS Sbjct: 186 GSAPPRIEEVVALLEKDDVITHYLNGKENNLFDEEGKPLSVLLDAVKRGVHLDVGHGNAS 245 Query: 257 FSFRIAGQAKKAGIPLNTISTDIYRGNRLNGPVYSMSNVLSKFLYLGYSLEEIIHAVTRN 316 FSF++A AK+ GI NTISTDIYR NR++GPVYSM+NVLSKFLYLGY LEE+I AVT+N Sbjct: 246 FSFKVAEAAKRYGIAFNTISTDIYRKNRIHGPVYSMANVLSKFLYLGYPLEEVIDAVTKN 305 Query: 317 AALWLKRPELAGISVGQQANLTLFALEEGRKELTDSEGDVRVADHYIEAKGVFANGSLIT 376 AA WLKRPEL I VG ANLTLF +++ L DSEGD RVA+ I+ KGV NG I Sbjct: 306 AAEWLKRPELGRIQVGDIANLTLFTVKDESITLIDSEGDQRVAERRIDTKGVVINGLFIE 365 Query: 377 C 377 C Sbjct: 366 C 366 >C2Q2I2.1 C2Q2I2_BACCE Dihydroorotase Length = 366 Score = 478 bits (1231), Expect = e-133, Method: Compositional matrix adjust. Identities = 231/361 (63%), Positives = 279/361 (77%) Query: 17 VLRNLQLVDGRTVDIAIRDGIISAITPAGRAEGKTMLDGSGLYVSSGWIDLHVHAVPELH 76 VLRN++ V+G +DI + + I+ +T AG EG+ +LD SG YVSSGWIDLHVHA PE Sbjct: 6 VLRNVKRVNGEEIDIVVENNKIAQVTKAGAGEGEKVLDYSGTYVSSGWIDLHVHAFPEFD 65 Query: 77 PYGDDIDEIGVKQGVTTIVDAGSCGADRIGAFYAGSLLAATNVLAFLNISRIGLERTDEL 136 PYGD++DEIGVKQGVTTIVDAGSCGADRI A TN+ AFLNISRIGL+R DEL Sbjct: 66 PYGDEVDEIGVKQGVTTIVDAGSCGADRIADLVQSREQAKTNLFAFLNISRIGLKRIDEL 125 Query: 137 SQLEWIDRDEAVQAAAAYPDFIVGLKARISQSVVKENGIQPLKQARALSGETKLPLMVHI 196 S +EWID+++ + Y D IVGLKAR+S+SVV ++GI+PL AR+LS ET LP+MVHI Sbjct: 126 SNMEWIDKEKVIDVVEKYKDVIVGLKARMSKSVVCDSGIEPLHVARSLSRETSLPIMVHI 185 Query: 197 GSAPPEISEVLELLQPGDVITHYLNGKSNNLFHADGTPLQGLLEAVAKGVHLDVGHGTAS 256 GSAPP I EV+ LL+ DVITHYLNGK NNLF +G PL LL+AV +GVHLDVGHG AS Sbjct: 186 GSAPPRIEEVVPLLEKDDVITHYLNGKENNLFDEEGKPLSVLLDAVKRGVHLDVGHGNAS 245 Query: 257 FSFRIAGQAKKAGIPLNTISTDIYRGNRLNGPVYSMSNVLSKFLYLGYSLEEIIHAVTRN 316 FSF++A AK+ GI LNTISTDIYR NR++GPVYSM++VLSKFLYLGY+LEE+I AVT+N Sbjct: 246 FSFKVAEAAKRHGIALNTISTDIYRKNRIHGPVYSMAHVLSKFLYLGYTLEEVIDAVTKN 305 Query: 317 AALWLKRPELAGISVGQQANLTLFALEEGRKELTDSEGDVRVADHYIEAKGVFANGSLIT 376 AA WLK+PEL I VG ANLTLF +++ L DSEGD R+A+ I+ KGV NGS I Sbjct: 306 AAEWLKKPELGRIQVGDIANLTLFTVKDEPITLIDSEGDQRIAERRIDTKGVVINGSFIE 365 Query: 377 C 377 C Sbjct: 366 C 366 >B9J2E7.1 B9J2E7_BACCQ Adenine deaminase; dihydroorotase Length = 366 Score = 477 bits (1227), Expect = e-133, Method: Compositional matrix adjust. Identities = 232/361 (64%), Positives = 279/361 (77%) Query: 17 VLRNLQLVDGRTVDIAIRDGIISAITPAGRAEGKTMLDGSGLYVSSGWIDLHVHAVPELH 76 VLRN++ V+G +DI I + I+ +T AG EG +LD SG YVSSGWIDLHVHA PE Sbjct: 6 VLRNVKRVNGEEIDIVIENNKIAQVTKAGAGEGGKVLDYSGTYVSSGWIDLHVHAFPEFD 65 Query: 77 PYGDDIDEIGVKQGVTTIVDAGSCGADRIGAFYAGSLLAATNVLAFLNISRIGLERTDEL 136 PYGD++DEIGVKQGVTTIVDAGSCGADRI LA TN+ AFLNISRIGL+R DEL Sbjct: 66 PYGDEVDEIGVKQGVTTIVDAGSCGADRIADLVKSRELAKTNLFAFLNISRIGLKRIDEL 125 Query: 137 SQLEWIDRDEAVQAAAAYPDFIVGLKARISQSVVKENGIQPLKQARALSGETKLPLMVHI 196 S +EWID+++ ++A Y D IVGLKAR+S+SVV ++GI+PL AR+LS ET LP+MVHI Sbjct: 126 SNMEWIDKEKVIEAVEKYKDVIVGLKARMSKSVVCDSGIEPLHVARSLSRETSLPIMVHI 185 Query: 197 GSAPPEISEVLELLQPGDVITHYLNGKSNNLFHADGTPLQGLLEAVAKGVHLDVGHGTAS 256 GSAPP I EV+ LL+ DVITHYLNGK NNLF +G PL LL+AV +GVHLDVGHG AS Sbjct: 186 GSAPPRIEEVVPLLEKDDVITHYLNGKENNLFDEEGKPLPVLLDAVNRGVHLDVGHGNAS 245 Query: 257 FSFRIAGQAKKAGIPLNTISTDIYRGNRLNGPVYSMSNVLSKFLYLGYSLEEIIHAVTRN 316 FSF++A AK+ I LNTISTDIYR NR++GPVYSM++VLSKFLYLGY LEE+I AVT+N Sbjct: 246 FSFKVAEAAKRHDIALNTISTDIYRKNRVHGPVYSMAHVLSKFLYLGYPLEEVIDAVTKN 305 Query: 317 AALWLKRPELAGISVGQQANLTLFALEEGRKELTDSEGDVRVADHYIEAKGVFANGSLIT 376 AA WLK+PEL I G ANLTLF +++ + L DSEGD R+A+ I+ KGV NGS I Sbjct: 306 AAEWLKKPELGRIQEGDIANLTLFTVKDEKITLIDSEGDQRIAERRIDTKGVVINGSFIE 365 Query: 377 C 377 C Sbjct: 366 C 366 >Q3EP60.1 Q3EP60_BACTI Dihydroorotase Length = 366 Score = 476 bits (1225), Expect = e-132, Method: Compositional matrix adjust. Identities = 232/361 (64%), Positives = 278/361 (77%) Query: 17 VLRNLQLVDGRTVDIAIRDGIISAITPAGRAEGKTMLDGSGLYVSSGWIDLHVHAVPELH 76 VLRN++ V+G +DI I + I+ +T AG EG +LD SG YVSSGWIDLHVHA PE Sbjct: 6 VLRNVKRVNGEEIDIVIENNKIAQVTKAGAGEGGKVLDYSGTYVSSGWIDLHVHAFPEFD 65 Query: 77 PYGDDIDEIGVKQGVTTIVDAGSCGADRIGAFYAGSLLAATNVLAFLNISRIGLERTDEL 136 PYGD++DEIGVKQGVTTIVDAGSCGADRI A TN+ AFLNISRIGL+R DEL Sbjct: 66 PYGDEVDEIGVKQGVTTIVDAGSCGADRIADLVKSREQAKTNLFAFLNISRIGLKRIDEL 125 Query: 137 SQLEWIDRDEAVQAAAAYPDFIVGLKARISQSVVKENGIQPLKQARALSGETKLPLMVHI 196 S +EWID+++A++A Y D IVGLKAR+S+SVV ++GI+PL ARALS ET LP+MVHI Sbjct: 126 SNMEWIDKEKAIEAVEKYKDVIVGLKARMSKSVVCDSGIEPLHVARALSRETSLPIMVHI 185 Query: 197 GSAPPEISEVLELLQPGDVITHYLNGKSNNLFHADGTPLQGLLEAVAKGVHLDVGHGTAS 256 GSAPP I EV+ LL+ DVITHYLNGK NNLF +G PL LL+AV +GVHLDVGHG AS Sbjct: 186 GSAPPRIEEVVPLLEKDDVITHYLNGKENNLFDEEGKPLPVLLDAVNRGVHLDVGHGNAS 245 Query: 257 FSFRIAGQAKKAGIPLNTISTDIYRGNRLNGPVYSMSNVLSKFLYLGYSLEEIIHAVTRN 316 FSF++A AK+ GI TISTDIYR NR++GPVYSM++VLSKFLYLGY LEE+I AVT+N Sbjct: 246 FSFKVAEAAKRYGIAFRTISTDIYRKNRIHGPVYSMAHVLSKFLYLGYPLEEVIDAVTKN 305 Query: 317 AALWLKRPELAGISVGQQANLTLFALEEGRKELTDSEGDVRVADHYIEAKGVFANGSLIT 376 AA WLK+PEL I G ANLTLF +++ + L DSEGD R+A+ I+ KGV NGS I Sbjct: 306 AAEWLKKPELGRIQEGDIANLTLFTVKDEKVTLIDSEGDQRIAERRIDTKGVVINGSFIE 365 Query: 377 C 377 C Sbjct: 366 C 366 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.317 0.136 0.389 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,266,375,721 Number of extensions: 98906681 Number of successful extensions: 272322 Number of sequences better than 1.0e-05: 227 Number of HSP's gapped: 272218 Number of HSP's successfully gapped: 227 Length of query: 377 Length of database: 3,060,696,203 Length adjustment: 137 Effective length of query: 240 Effective length of database: 1,770,017,148 Effective search space: 424804115520 Effective search space used: 424804115520 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 132 (55.5 bits)