BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0377.0025.p (1085 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KGE6.1 B3KGE6_9BACI Alpha-mannosidase EC=3.2.1.24 893 0.0 B0K7M7.1 B0K7M7_THEP3 Alpha-mannosidase EC=3.2.1.24 644 0.0 B0K6B8.1 B0K6B8_THEPX Alpha-mannosidase EC=3.2.1.24 641 0.0 Q9AJR6.2 Q9AJR6_BACGL Alpha-D-mannosidase 611 e-172 Q5KYP9.1 Q5KYP9_GEOKA Alpha-D-mannosidase EC=3.2.1.24 363 7e-98 >B3KGE6.1 B3KGE6_9BACI Alpha-mannosidase EC=3.2.1.24 Length = 868 Score = 893 bits (2307), Expect = 0.0, Method: Compositional matrix adjust. Identities = 455/872 (52%), Positives = 565/872 (64%), Gaps = 50/872 (5%) Query: 1 MKRINRFIDWLAERQWTERIELTEWKLRKSRYLAPGVYEHEEELHPDYKISRLDGGYGTT 60 M+RI RFI L+ERQW E EL +W + +S Y+ PGVYE +R GTT Sbjct: 1 MERIRRFIRELSERQWLESTELRDWNITRSAYMVPGVYEETAPYPEGQNFNRFPSTQGTT 60 Query: 61 YFLQRQVAVPEGWAPEETALLYIGRGEGLLSINGAPYHGLDSNHWFISLPPGSTGGELTL 120 YF +R + +P WA L++ GEGLL INGA Y GLD NH F+ L P TG + L Sbjct: 61 YFFRRNLELPLKWADGAIGLVFQSGGEGLLRINGASYQGLDRNHTFVKLDPKRTGMNMEL 120 Query: 121 DIELYDPVPEPEDPLNRQAVIKPPLEGVTISLVRVHLPVYSLLHTVKTAHEAALLLPEGD 180 +IEL+DP+PEP DPLN+QAVI+PP+ V LVRV++PV SL++T ++ +LLP+ D Sbjct: 121 EIELFDPIPEPVDPLNQQAVIQPPITRVQSLLVRVNVPVQSLMYTATVIRDSLILLPDTD 180 Query: 181 MRRIRTLQALEQAMDALY-MKGHLLYSGDAAAGVEERLRAAVSMERSAGTSEGIMHMVGQ 239 MRRIR ++AL QAMD + + G +E L+ +V+ G +EG HMVGQ Sbjct: 181 MRRIRMMEALYQAMDRFVGLNDAAIRDGAEVTAIEHDLKQSVAA--IGGHAEGTEHMVGQ 238 Query: 240 SHIDIAWLWPIRETVRKVSRTFSTVCALMDKYPDFRYSQSQPQLYAYAKAYYPGLYERIK 299 SHIDIAWLWP+RETVRK SRTFST+ ALM++YP+F+Y+QSQP LY + K + P LYER+K Sbjct: 239 SHIDIAWLWPVRETVRKTSRTFSTMDALMNEYPEFKYAQSQPLLYQFLKDHDPELYERVK 298 Query: 300 ARIAEGRWELVGGMWVEPDLNIPGGESLVRQMLYGQGFYMQEFGKRSTVEWLPDTFGYCA 359 ARI EGRWELVGGMWVEPDLNIP GESL+RQMLYGQ FY +EFG S +EWLPDTFGYCA Sbjct: 299 ARIKEGRWELVGGMWVEPDLNIPSGESLMRQMLYGQRFYQEEFGLTSQIEWLPDTFGYCA 358 Query: 360 SLPQLLKQAGIDYFMTTKLGWNDTNPFPHTLFHWVGIDGTKIVAYQNHGVNEHTRPKDVQ 419 SLPQ+LK GI YFMTTKLGWNDTN FP+ LFHWVGIDGT +++Y NHGVNE+T PKDV Sbjct: 359 SLPQILKHGGIRYFMTTKLGWNDTNVFPYDLFHWVGIDGTPMLSYLNHGVNENTLPKDVH 418 Query: 420 EHWQSNAQKDRHNELMLLYXXXXXXXXVTHEMLEYVARTDLMPGQPVSGFSTAEAFFSEI 479 EHWQS QK H E MLLY VT EMLEY+ R +LM GQP S +STA FF I Sbjct: 419 EHWQSYRQKAVHPEQMLLYGHGDGGGGVTREMLEYINRAELMVGQPASKYSTAAEFFDGI 478 Query: 480 GARQPELPKWYGDLYLELHRGTFTTHAYNKRSNRKAEILYRQAEIW-SVXXXXXXXXXXX 538 A QP+LPKW GDLYLELHRGT+TTHA NKR NRKAEILYR+AE+W SV Sbjct: 479 DAAQPKLPKWRGDLYLELHRGTYTTHARNKRHNRKAEILYREAELWNSVAFPSMDNEKKQ 538 Query: 539 XXKPKLDGGWKLMLLNQFHDIIPGTSISEVYTTSREQYAEVFSLGRQVLETSLHALASKV 598 +L GWKL+LLNQFHDIIPG++I+E Y TS ++YAEVF G L+ L LA + Sbjct: 539 GIVSELHDGWKLILLNQFHDIIPGSAITESYVTSEKEYAEVFQKGNHSLDLGLQVLADQA 598 Query: 599 DTSGAGRPYVAFNSLGWERTELIRLEGDCSLAAVQAFDEEGR-LDSECWSMEGDSGRYTL 657 DT G G PYV FN LGW R +I LE + L +D +G L + S E L Sbjct: 599 DTEGEGVPYVIFNGLGWRRDAVISLEVEHGLT---PYDSDGAPLPFDALSGENGETSQRL 655 Query: 658 VVRVRKVPAFGCRVFWLREAAERGRGXXXXXXXXXXXXXXXXXXXXXXXXXXLLESSEGA 717 V V+ +PA G WL+ +A Sbjct: 656 NVHVQGIPALGYTTIWLKPSAG-------------------------------------- 677 Query: 718 AGPVNGLAGISAGDAFPDLWETEYYILQFNEDGEISRWYDKSAGRELLPPGQTGNQLRYY 777 NG A + F D WET++Y + FNE GEI+ +DK A RE++ G+ N+ ++ Sbjct: 678 ----NGKAAEKSTTVFADSWETDFYKVSFNERGEITSLWDKEAHREVIKTGEAANRFHFF 733 Query: 778 HDTPPLWDAWDLDPRYEQQPAGRAELLERKVLVSGPVLTVLKFRWQLNQSLIEQEIILPR 837 HD P LWDAWD+D RYE+Q AG AEL+E+K++ +G V VL+FRW+++QS I Q++I Sbjct: 734 HDRPTLWDAWDIDTRYEEQSAGDAELIEKKLVSAGEVQDVLRFRWRIHQSEITQDMIFYH 793 Query: 838 HSRRVDFQTRVSWKEEHKLLKAAFPVDIVAAK 869 H RR+DF+T VSW E HKLLK FP+ +VA K Sbjct: 794 HDRRIDFKTFVSWNESHKLLKVGFPIGVVAEK 825 >B0K7M7.1 B0K7M7_THEP3 Alpha-mannosidase EC=3.2.1.24 Length = 1053 Score = 644 bits (1660), Expect = 0.0, Method: Compositional matrix adjust. Identities = 390/1112 (35%), Positives = 584/1112 (52%), Gaps = 110/1112 (9%) Query: 1 MKRINRFIDWLAERQWTERIELTEWKLRKSRYLAPGVYEHEEELHPDYKISRLDGGYGTT 60 ++RI R + L +++ + + ++ ++ Y + + E + E +K GG Sbjct: 5 LERIERILKELESYIYSQEVPVDMYRFKECGYNSYHLLEEDGENWDIFKRGDRYGGTDKH 64 Query: 61 YFLQRQVAVPEGWAPEETALLYIGRG-EG---------LLSINGAPYHGLDSNHWFISLP 110 ++ + Q+A+PE + + T + + G EG + +N GLD NH I L Sbjct: 65 FWFKTQIAIPETFEGK-TVVYKVSTGREGEWDALNPQFFIYVNKKLIQGLDVNHREIILT 123 Query: 111 PGSTGGELTLDIELYDPVPEPE---DPLNRQAVIKPPLEGVTISLVRVHLPVYSLLHTVK 167 + GE DI+LY E D A+++ +E L + +K Sbjct: 124 ENAKAGE-KYDIDLYAFAGMLEGYIDLYTEIAILEKEIE--------------KLYYNIK 168 Query: 168 TAHEAALLLPEGDMRRIRTLQALEQAMDALYMKGHLLYSGDAAAGVE---ERLRAAVSME 224 + LL + + I T++ L+ A++ L ++ +S D + E L E Sbjct: 169 VPLDIIKLLEKDSLEYINTIKYLQTAINILDLRKP--FSKDFYNSINKANEYLEKEF-YE 225 Query: 225 RSAGTSEGIMHMVGQSHIDIAWLWPIRETVRKVSRTFSTVCALMDKYPDFRYSQSQPQLY 284 + G + I VG +HIDIAWLW + +T K +R+FSTV LM +YP++ + SQPQLY Sbjct: 226 KYCGHDDVIEICVGHTHIDIAWLWTLSQTKEKAARSFSTVLNLMKQYPEYIFISSQPQLY 285 Query: 285 AYAKAYYPGLYERIKARIAEGRWELVGGMWVEPDLNIPGGESLVRQMLYGQGFYMQEFGK 344 + K +P +YE IK RI EGRWE G MWVE D N+ GESLVRQ+L+G+ F+ +EFG Sbjct: 286 KFIKEDHPEIYEEIKRRIKEGRWEAEGSMWVEADTNLTSGESLVRQILFGKRFFKKEFGV 345 Query: 345 RSTVEWLPDTFGYCASLPQLLKQAGIDYFMTTKLGWNDTNPFPHTLFHWVGIDGTKIVAY 404 + + WLPD FGY A+LPQ+LK++GIDYFMTTK+ WN+ N P+ F W GIDGT+I+ + Sbjct: 346 DNKILWLPDVFGYSAALPQILKKSGIDYFMTTKISWNEYNKMPYDTFMWRGIDGTEILTH 405 Query: 405 ----------QNHG----VNEHTRPKDVQEHWQSNAQKDRHNELMLLYXXXXXXXXVTHE 450 + G N + P V WQ QK+ +N ++ Y T E Sbjct: 406 FITTTDYVKGEPKGWFTTYNGNLNPSQVMGCWQRYQQKEINNYVLNSYGYGDGGGGPTKE 465 Query: 451 MLEYVAR-TDLMPGQPVSGFSTAEAFFSE---IGARQPELPKWYGDLYLELHRGTFTTHA 506 MLE R +PG P A FF + I P+LPKW G+LYLE HRGT+T+ A Sbjct: 466 MLENGKRLAKGIPGAPKVKMGKAIDFFKQLEKIVKGNPKLPKWVGELYLEYHRGTYTSMA 525 Query: 507 YNKRSNRKAEILYRQAEIWSVXXXXXXXXXXXXXKPKLDGGWKLMLLNQFHDIIPGTSIS 566 NK+ NRK E L +E++S + +++ W++ LLNQFHDIIPG+SI Sbjct: 526 RNKKYNRKTEFLNLDSELFST--MNMILQGKKYPQSEINKNWEITLLNQFHDIIPGSSIK 583 Query: 567 EVYTTSREQYAEVFSLGRQVLETSLHALASKVDTSGAGRPYVAFNSLGWERTELIRLEGD 626 EVY S++QY E+ + G+ ++ ++L ++ S ++ V FN L +ER++++ E Sbjct: 584 EVYEESKKQYEEINARGKNIINSALDSICSNINLKNIS--LVVFNQLSFERSDIVEFELP 641 Query: 627 CSLAAVQAFDEEGRLDSECWSMEGDSGRYTLVVRVRKVPAFGCRVFWLREAAERGRGXXX 686 + V +D E + S+ G ++ VP+ G +V+ L++A + Sbjct: 642 EGWSNVLVYDGEKLITSQ------KVGSNKIIFFAENVPSKGYKVYTLKKAENFSQT--- 692 Query: 687 XXXXXXXXXXXXXXXXXXXXXXXLLESSEGAAGPVNGLAGISAGDAFPDLWETEYYILQF 746 SSE I+ + + +++ ++ Sbjct: 693 --------------------------SSE---------IKINEKEI-----QNKFFNIKL 712 Query: 747 NEDGEISRWYDKSAGRELLPPGQTGNQLRYYHDTPPLWDAWDLDPRYEQQPAGRAELLER 806 +++G I YDK RE+L Q GN L+ + D P +DAWD++ Y+++ ++ + Sbjct: 713 DDNGNIISIYDKLNEREVLKNNQKGNVLQAFEDKPHNFDAWDINIYYQEKMWEINDVEKI 772 Query: 807 KVLVSGPVLTVLKFRWQLNQSLIEQEIILPRHSRRVDFQTRVSWKEEHKLLKAAFPVDIV 866 +VL +GPV LK + + S IEQ I + R+DF ++ WKE+ LLK AFPVDI Sbjct: 773 EVLETGPVRGALKVKKKFLDSTIEQIIYVYNDIPRIDFNNKIDWKEKQILLKVAFPVDIH 832 Query: 867 AAKATYEIPFGALERPTHRNTSWEQAQFEVCGHRWADLSESGYGASLLNDCKYGYDIHDG 926 A KATYEI FG +ERPTH NTSW+ A+FEV H+WADLSE GYG SLLND KYGYDI D Sbjct: 833 ADKATYEIQFGNIERPTHWNTSWDYARFEVPAHKWADLSEGGYGVSLLNDSKYGYDIKDL 892 Query: 927 VMRLSLLRSPRWPDRQADRGEHVFTYSLYPHTGDWRQAQVVRAAAELNEPLLAVSEDPHP 986 VMRL+LL+S +P+ +AD+ H F YSLYPH GDW+ V+ A LN P+ A E PH Sbjct: 893 VMRLTLLKSAIYPNEEADKEIHEFVYSLYPHKGDWKDGNTVKMAYNLNCPMYAKIEGPHD 952 Query: 987 GRYPSTYAWLGLQSGPVVLDTIKNAEDGSGIIVRLYESTGGRGTATLNW--QTADIGACR 1044 G P ++ L + V+++T+K AE+ IIVRLYE R TL + D+ C Sbjct: 953 GVLPERFSLLNVDKENVIVETVKKAEESDDIIVRLYEYQNKREKVTLTLFKEIKDVIEC- 1011 Query: 1045 VNLLECGTEPLDTAGGALTLSFKPYEVQTVKL 1076 +L+E +D G + KPYE++T K+ Sbjct: 1012 -DLMENEINKIDFEGNSFKFEIKPYEIKTFKI 1042 >B0K6B8.1 B0K6B8_THEPX Alpha-mannosidase EC=3.2.1.24 Length = 1044 Score = 641 bits (1653), Expect = 0.0, Method: Compositional matrix adjust. Identities = 389/1112 (34%), Positives = 583/1112 (52%), Gaps = 110/1112 (9%) Query: 1 MKRINRFIDWLAERQWTERIELTEWKLRKSRYLAPGVYEHEEELHPDYKISRLDGGYGTT 60 ++RI R + L +++ + + ++ ++ Y + + E + E +K GG Sbjct: 5 LERIERILKELESYIYSQEVPVDMYRFKECGYNSYHLLEEDGENWDIFKRGDRYGGTDKH 64 Query: 61 YFLQRQVAVPEGWAPEETALLYIGRG-EG---------LLSINGAPYHGLDSNHWFISLP 110 ++ + Q+A+PE + + T + + G EG + +N GLD NH I L Sbjct: 65 FWFKTQIAIPETFEGK-TVVYKVSTGREGEWDALNPQFFIYVNKKLIQGLDVNHREIILT 123 Query: 111 PGSTGGELTLDIELYDPVPEPE---DPLNRQAVIKPPLEGVTISLVRVHLPVYSLLHTVK 167 + GE DI+LY E D A+++ +E L + +K Sbjct: 124 ENAKAGE-KYDIDLYAFAGMLEGYIDLYTEIAILEKEIE--------------KLYYNIK 168 Query: 168 TAHEAALLLPEGDMRRIRTLQALEQAMDALYMKGHLLYSGDAAAGVE---ERLRAAVSME 224 + LL + + I T++ L+ A++ L ++ +S D + E L E Sbjct: 169 VPLDIIKLLEKDSLEYINTIKYLQTAINILDLRKP--FSKDFYNSINKANEYLEKEF-YE 225 Query: 225 RSAGTSEGIMHMVGQSHIDIAWLWPIRETVRKVSRTFSTVCALMDKYPDFRYSQSQPQLY 284 + G + I VG +HIDIAWLW + +T K +R+FSTV LM +YP++ + SQPQLY Sbjct: 226 KYCGHDDVIEICVGHTHIDIAWLWTLSQTKEKAARSFSTVLNLMKQYPEYIFISSQPQLY 285 Query: 285 AYAKAYYPGLYERIKARIAEGRWELVGGMWVEPDLNIPGGESLVRQMLYGQGFYMQEFGK 344 + K +P +YE IK RI EGRWE G MWVE D N+ GESLVRQ+L+G+ F+ +EFG Sbjct: 286 KFIKEDHPEIYEEIKRRIKEGRWEAEGSMWVEADTNLTSGESLVRQILFGKRFFKKEFGV 345 Query: 345 RSTVEWLPDTFGYCASLPQLLKQAGIDYFMTTKLGWNDTNPFPHTLFHWVGIDGTKIVAY 404 + + WLPD FGY A+LPQ+LK++GIDYFMTTK+ WN+ N P+ F W GIDGT+I+ + Sbjct: 346 DNKILWLPDVFGYSAALPQILKKSGIDYFMTTKISWNEYNKMPYDTFMWRGIDGTEILTH 405 Query: 405 ----------QNHG----VNEHTRPKDVQEHWQSNAQKDRHNELMLLYXXXXXXXXVTHE 450 + G N + P V WQ QK+ +N ++ Y T E Sbjct: 406 FITTTDYVKGEPKGWFTTYNGNLNPSQVMGCWQRYQQKEINNYVLNSYGYGDGGGGPTKE 465 Query: 451 MLEYVAR-TDLMPGQPVSGFSTAEAFFSE---IGARQPELPKWYGDLYLELHRGTFTTHA 506 MLE R +PG P A FF + I P+LPKW G+LYLE HRGT+T+ A Sbjct: 466 MLENGKRLAKGIPGAPKVKMGKAIDFFKQLEKIVKGNPKLPKWVGELYLEYHRGTYTSMA 525 Query: 507 YNKRSNRKAEILYRQAEIWSVXXXXXXXXXXXXXKPKLDGGWKLMLLNQFHDIIPGTSIS 566 NK+ NRK E L +E++S + +++ W++ LLNQFHDIIPG+SI Sbjct: 526 RNKKYNRKTEFLNLDSELFST--MNMILQGKKYPQSEINKNWEITLLNQFHDIIPGSSIK 583 Query: 567 EVYTTSREQYAEVFSLGRQVLETSLHALASKVDTSGAGRPYVAFNSLGWERTELIRLEGD 626 EVY S++QY E+ + G+ ++ ++L ++ S ++ V FN L +ER++++ E Sbjct: 584 EVYEESKKQYEEINARGKNIINSALDSICSNINLKNIS--LVVFNQLSFERSDIVEFELP 641 Query: 627 CSLAAVQAFDEEGRLDSECWSMEGDSGRYTLVVRVRKVPAFGCRVFWLREAAERGRGXXX 686 + V +D E + S+ G ++ V + G +V+ L++A + Sbjct: 642 EGWSDVLVYDGEKLITSQ------KVGSNKIIFFAENVSSKGYKVYTLKKAENFSQT--- 692 Query: 687 XXXXXXXXXXXXXXXXXXXXXXXLLESSEGAAGPVNGLAGISAGDAFPDLWETEYYILQF 746 SSE I+ + + +++ ++ Sbjct: 693 --------------------------SSE---------IKINEKEM-----QNKFFNIKL 712 Query: 747 NEDGEISRWYDKSAGRELLPPGQTGNQLRYYHDTPPLWDAWDLDPRYEQQPAGRAELLER 806 +++G I YDK RE+L Q GN L+ + D P +DAW+++ Y+++ E+ + Sbjct: 713 DDNGNIISIYDKLNEREVLKNNQKGNVLQAFEDKPHNFDAWNINIYYQEKMWEINEVEKI 772 Query: 807 KVLVSGPVLTVLKFRWQLNQSLIEQEIILPRHSRRVDFQTRVSWKEEHKLLKAAFPVDIV 866 +VL +GPV LK + + S IEQ I + R+DF ++ WKE+ LLK AFPVDI Sbjct: 773 EVLETGPVRGALKVKKKFLDSTIEQIIYVYNDIPRIDFNNKIDWKEKQILLKVAFPVDIH 832 Query: 867 AAKATYEIPFGALERPTHRNTSWEQAQFEVCGHRWADLSESGYGASLLNDCKYGYDIHDG 926 A KATYEI FG +ERPTH NTSW+ A+FEV H+WADLSE GYG SLLND KYGYDI D Sbjct: 833 ADKATYEIQFGNIERPTHWNTSWDYARFEVPAHKWADLSEGGYGVSLLNDSKYGYDIKDL 892 Query: 927 VMRLSLLRSPRWPDRQADRGEHVFTYSLYPHTGDWRQAQVVRAAAELNEPLLAVSEDPHP 986 VMRL+LL+S +P+ +AD+ H F YSLYPH GDW+ V+ A LN P+ A E PH Sbjct: 893 VMRLTLLKSAIYPNEEADKEIHEFVYSLYPHKGDWKDGNTVKMAYNLNCPMYAKIEGPHD 952 Query: 987 GRYPSTYAWLGLQSGPVVLDTIKNAEDGSGIIVRLYESTGGRGTATLNW--QTADIGACR 1044 G P ++ L + V+++T+K AE+ IIVRLYE R TL + D+ C Sbjct: 953 GVLPERFSLLNVDKENVIVETVKKAEESDDIIVRLYEYQNKREKVTLTLFKEIKDVIEC- 1011 Query: 1045 VNLLECGTEPLDTAGGALTLSFKPYEVQTVKL 1076 +L+E +D G + KPYE++T K+ Sbjct: 1012 -DLMENEINKIDFEGNSFKFEIKPYEIKTFKI 1042 >Q9AJR6.2 Q9AJR6_BACGL Alpha-D-mannosidase Length = 1047 Score = 611 bits (1576), Expect = e-172, Method: Compositional matrix adjust. Identities = 400/1122 (35%), Positives = 568/1122 (50%), Gaps = 134/1122 (11%) Query: 1 MKRINRFIDWLAERQWTERIELTEWKLRKSRYLAPGVYEHEEELHPDYKISRLDG--GYG 58 ++++ + I+ LA ++ + L EW++++ A GV EL + ++ + + GY Sbjct: 5 VEKLQKRIEELAAYRYRHALPLDEWEMQEDEAGANGV-SRPPELTGELRMRKGERWVGYD 63 Query: 59 TTYFLQRQVAVPEGWAPEETALLY----IGRG-----EGLLSINGAPYHGLDSNHWFISL 109 +L+R+V VPE W E L+ G G E LL +NG P+ G+D+NH + + Sbjct: 64 RYVWLRRKVRVPEDWKGREVVGLFDFGLTGAGNNAAFESLLYLNGRPFQGVDTNHQEVFV 123 Query: 110 PPGSTGGELTLDIELYDPVPEPEDPLNRQAVIKPPLEGVTISLVRVHLPVYSLLHTVKTA 169 P G E+ L L+ + P +++ K L + L T + A Sbjct: 124 PAELAGSEIELVFRLWSGLEGGGGPRDQEHQFK------RAELAVLDAAADDLYFTGRAA 177 Query: 170 HEAALLLPEGDMRRIRTLQALEQAM----------DALYMKGHLLYSGDAAAGVEERLRA 219 E A +L E + + L A ++A D Y+ L + DA LR Sbjct: 178 LETAKILEESNPFKHDLLTAADRAFKLLDWSRPGSDEFYVSVGL--AADA-------LRT 228 Query: 220 AVSMERSAGTSEGIMHMVGQSHIDIAWLWPIRETVRKVSRTFSTVCALMDKYPDFRYSQS 279 A+S + +G +HID+AWLW ++ T K +R+FSTV LM+KYP++ + Q+ Sbjct: 229 ALS--ELDNKHPVTVRALGHTHIDVAWLWQLKHTREKSARSFSTVLRLMEKYPEYLFLQT 286 Query: 280 QPQLYAYAKAYYPGLYERIKARIAEGRWELVGGMWVEPDLNIPGGESLVRQMLYGQGFYM 339 QPQLYAY K YP +YE+I+ R+ EGRWE G MW+E D N+ GESLVRQ+L+G F+ Sbjct: 287 QPQLYAYLKKDYPEIYEQIRERVKEGRWEAGGAMWLEADCNLTSGESLVRQILHGTRFFR 346 Query: 340 QEFGKRSTVEWLPDTFGYCASLPQLLKQAGIDYFMTTKLGWNDTNPFPHTLFHWVGIDGT 399 EFG WLPD FGY +LPQ+L+++GI FMTTK+ WN N PH F W GIDG+ Sbjct: 347 DEFGVECDYLWLPDVFGYSWALPQILRKSGIKTFMTTKISWNQYNRMPHDTFKWRGIDGS 406 Query: 400 KI---------VAYQN---HGVNEHTRPKDVQEHWQSNAQKDRHNELMLLYXXXXXXXXV 447 +I VA N + N P V+ W + KD + EL+L Y V Sbjct: 407 EILTHFITTPEVADPNVWWYTYNGQIEPFTVKGIWDTYRDKDINRELLLSYGYGDGGGGV 466 Query: 448 THEMLEYVARTDLMPGQPVSGFSTAEAFFSE----IGARQPELPKWYGDLYLELHRGTFT 503 MLE R D MPG P A FF + + + W G+LYLE HRGT+T Sbjct: 467 NRHMLEMRRRLDEMPGLPKVVPGRAGDFFDKLHETVAGTDRYVHTWDGELYLEYHRGTYT 526 Query: 504 THAYNKRSNRKAEILYRQAE-IWSVXXXXXXXXXXXXXKPKLDGGWKLMLLNQFHDIIPG 562 + AYNKR NRK E++YR+AE + S+ K L GW +L NQFHDIIPG Sbjct: 527 SQAYNKRMNRKLELMYREAEWLHSLGAVAGGGDWSGYPKEALYEGWTTILRNQFHDIIPG 586 Query: 563 TSISEVYTTSREQYAEVFSLGRQVLETSLHALASKVDTSGAGRPYVAFNSLGWERTELIR 622 +SI VY +R +YAE LG++ ++ + LA + + G +N ++RTEL+ Sbjct: 587 SSIGAVYQDARAEYAEAERLGKEAIQAAAERLAGQAE----GAVVSVYNGAAFDRTELVE 642 Query: 623 LEGDCSLAAVQA-FDEEGRLDSECWSMEGDSGRYTLVVRVRKVPAFGCRVFWLREAAERG 681 + + + E GR E D R+ +V VPA G Sbjct: 643 IPVQAGIGSQGGWLGEAGR----PLRAEFDGSRW--LVLAEDVPATGAATL--------- 687 Query: 682 RGXXXXXXXXXXXXXXXXXXXXXXXXXXLLESSEGAAGPVNGLAGISAGDAFPDLWETEY 741 + +AG + D + T + Sbjct: 688 -------------------------------RFDPSAGQQTSVKAFEWADG---VLRTPH 713 Query: 742 YILQFNEDGEISRWYDKSAGRELLPPGQTGNQLRYYHDTPPLWDAWDLDPRYEQQPAGRA 801 Y L F+E G + R YD+ RE+LP G N+L+ + D P +++AWD+D Y+++ Sbjct: 714 YELAFDEAGRLVRLYDRGLSREVLPRGARANELQVFEDKPKMFEAWDIDLFYQEKRREVT 773 Query: 802 ELLERKVLVSGPVLTVLKFRWQLNQSLIEQEIILPRHSRRVDFQTRVSWKEEHKLLKAAF 861 +L + +++ G + VL+ W S+IEQ +++ RR+DF TRV W+E +LLK AF Sbjct: 774 DLRKLELVECGALRAVLRLEWAYGASVIEQRLVVYADDRRIDFVTRVDWREHQQLLKVAF 833 Query: 862 PVDIVAAKATYEIPFGALERPTHRNTSWEQAQFEVCGHRWADLSESGYGASLLNDCKYGY 921 PV+I A +ATY+I FG ++RPTH NTSW+ A+FE GH+W DLSE GYG SLLNDCKYG+ Sbjct: 834 PVEIRATEATYDIQFGNVKRPTHWNTSWDHARFETVGHQWVDLSERGYGVSLLNDCKYGH 893 Query: 922 DIHDGVMRLSLLRSPRWPDRQADRGEHVFTYSLYPHTGDWRQAQVVRAAAELNEPLLAVS 981 DI D V+RLSL++S PD AD+GEH+FTYSLYPH GDW AA LN PLLAV Sbjct: 894 DIKDNVIRLSLIKSAIDPDPNADQGEHLFTYSLYPHAGDWASGGTATAAWALNNPLLAV- 952 Query: 982 EDPHPGRYPSTYAWLGL---QSGPVVLDTIKNAEDGSGIIVRLYESTGGRGTATL----- 1033 PG S +A L + D IK AED ++VRL+E GGRG TL Sbjct: 953 ----PG--ASAFAGKSLLRADGAHIAFDAIKKAEDEDALVVRLHEYAGGRGLTTLTPGCE 1006 Query: 1034 --NWQTADIGACRVNLLECGTEPLDTAGGALTLSFKPYEVQT 1073 +WQ D+ + G +P L PYE++T Sbjct: 1007 IASWQECDLLERPIGDRHDGDKP-------LRFELAPYEIKT 1041 >Q5KYP9.1 Q5KYP9_GEOKA Alpha-D-mannosidase EC=3.2.1.24 Length = 1044 Score = 363 bits (931), Expect = 7e-98, Method: Compositional matrix adjust. Identities = 225/596 (37%), Positives = 320/596 (53%), Gaps = 55/596 (9%) Query: 62 FLQRQVAVPEGWAPEETALLY----IGRG-----EGLLSINGAPYHGLDSNHWFISLPPG 112 +LQ + +PE W +E L+ G G E LL +NG+PY G+DSNH + P G Sbjct: 66 WLQADIDIPEQWKGKEIVGLFDFGKTGEGNNSGFESLLYLNGSPYQGVDSNHMEVFFPKG 125 Query: 113 STGGELTLDIELYDPVPEPEDPLNRQAVIKPP----LEGVTISLVRVHLPVYSLLHTVKT 168 S G +++L L+ + P +++ IK L+ VT L ++L TVK Sbjct: 126 SAGAKISLTFRLWSGLEGGGIPKSQEHKIKRAEVAWLDEVTDDLF---FTGKAILGTVKV 182 Query: 169 ----AHEAALLLPEGDMRRIRTLQALEQAMDALYMKGHLLYSGDAAAGVEERLRAAVSME 224 + E LLL D R R + + D+ Y ++ A E L+ ++ Sbjct: 183 LGQHSPERQLLLSLLD-RAFRQIDWSKPKSDSFY---------NSVAIALEMLKD--ELK 230 Query: 225 RSAGTSEGIMHMVGQSHIDIAWLWPIRETVRKVSRTFSTVCALMDKYPDFRYSQSQPQLY 284 R + +G +HID+AWLW ++ T K +R+FSTV LM+KYP++ + Q+QPQLY Sbjct: 231 RMEKKHPVTIRCIGHTHIDVAWLWRLKHTREKAARSFSTVLRLMEKYPEYIFLQTQPQLY 290 Query: 285 AYAKAYYPGLYERIKARIAEGRWELVGGMWVEPDLNIPGGESLVRQMLYGQGFYMQEFGK 344 Y K+ YP ++E+I+ R+AEGRWE G MW+E D NIP GESLVRQ+L G F +EFG Sbjct: 291 EYIKSDYPEIFEQIRKRVAEGRWEAGGAMWLEADCNIPSGESLVRQILMGTRFLRKEFGV 350 Query: 345 RSTVEWLPDTFGYCASLPQLLKQAGIDYFMTTKLGWNDTNPFPHTLFHWVGIDGTKIVAY 404 WLPD FGY +LPQ+LK++GI FMTTK+ WN N PH F W GIDG++I+ + Sbjct: 351 ECKYLWLPDVFGYNWALPQILKKSGIHAFMTTKISWNQYNRMPHDTFIWRGIDGSEILTH 410 Query: 405 --------QN---HGVNEHTRPKDVQEHWQSNAQKDRHNELMLLYXXXXXXXXVTHEMLE 453 +N + N P+ VQ W++ K + EL+L Y V EMLE Sbjct: 411 FITTPEPNKNWWFYTYNGVITPETVQGIWEAYRDKAINQELLLSYGYGDGGGGVNREMLE 470 Query: 454 YVARTDLMPGQPVSGFSTAEAFFSEIGARQPELPK----WYGDLYLELHRGTFTTHAYNK 509 R + +PG P A+ FF + + + W G+LYLE HRGT+T+ AYNK Sbjct: 471 MRRRLNDIPGLPNVETGRADEFFERLNEKIRNTDQYVHVWDGELYLEYHRGTYTSQAYNK 530 Query: 510 RSNRKAEILYRQAEIWSVXXXXXXXXXXXXXKPKLDGGWKLMLLNQFHDIIPGTSISEVY 569 R NRK E+LYR+ E + +L+ GWK++L NQFHDIIPG+SI EVY Sbjct: 531 RMNRKMELLYRETEWMGIVSATLNSDWSRYPFERLNEGWKIILRNQFHDIIPGSSIREVY 590 Query: 570 TTSREQY--AEVFSLGRQVLETSLHALASKVDTSGAGRPYVAFNSLGWERTELIRL 623 SRE+Y AE ++L ++ L+ + G + FNS W RT+L+R+ Sbjct: 591 EDSREEYEKAEKYAL------SAWKNLSESIIVEKKGDTVIVFNSSPWVRTDLVRI 640 Score = 285 bits (730), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 145/338 (42%), Positives = 207/338 (61%), Gaps = 15/338 (4%) Query: 741 YYILQFNEDGEISRWYDKSAGRELLPPGQTGNQLRYYHDTPPLWDAWDLDPRYEQQPAGR 800 YY +++N+ G+I YD A RE+L G+ GN L+ + D P +DAWD+D Y+++ Sbjct: 711 YYKIKWNDKGQIISIYDLQAKREVLDDGKCGNVLQVFEDKPLRFDAWDIDIFYQEKKREV 770 Query: 801 AELLERKVLVSGPVLTVLKFRWQLNQSLIEQEIILPRHSRRVDFQTRVSWKEEHKLLKAA 860 +L + + V+ F W+ S+I+Q++IL HSRR+DF+T V WKE+++LLK A Sbjct: 771 EDLQHVSIKEITSLYAVIHFEWKYMDSIIKQDMILYTHSRRIDFKTEVDWKEQNQLLKVA 830 Query: 861 FPVDIVAAKATYEIPFGALERPTHRNTSWEQAQFEVCGHRWADLSESGYGASLLNDCKYG 920 FPV I + ATY+I FG ++RPTH NTSW+ A+FE H+WADLSE+GYG SLLNDCKYG Sbjct: 831 FPVKIRSTLATYDIQFGNVKRPTHWNTSWDYAKFETVAHQWADLSETGYGVSLLNDCKYG 890 Query: 921 YDIHDGVMRLSLLRSPRWPDRQADRGEHVFTYSLYPHTGDWRQAQVVRAAAELNEPLLAV 980 YDI D V+RLSL++S +PD Q D+G H+FTYSL PH GDW + V+ A LN PL Sbjct: 891 YDIKDNVIRLSLIKSATYPDYQQDQGYHIFTYSLLPHQGDWVEGNTVKEAWYLNNPLTYA 950 Query: 981 SEDPHPGRYPSTYAWLGLQSGPVVLDTIKNAEDGSGIIVRLYESTGGRGTATLNWQTADI 1040 +P + Y+ G + +++D +K AED + I++RL+E TG R + T+D+ Sbjct: 951 VGEPIRKK----YSLFGTNTDNIMVDVVKRAEDSNRIVLRLHEFTGRRNKVYI---TSDL 1003 Query: 1041 -----GACRVNLLECGTEPLDTAGGALTLSFKPYEVQT 1073 C + E G T L PYE++T Sbjct: 1004 PIFAWQECDLMEREVGE---GTISEKLEFDINPYEIKT 1038 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.318 0.136 0.426 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 6,873,629,501 Number of extensions: 301187213 Number of successful extensions: 597984 Number of sequences better than 1.0e-05: 435 Number of HSP's gapped: 596442 Number of HSP's successfully gapped: 760 Length of query: 1085 Length of database: 3,060,696,203 Length adjustment: 147 Effective length of query: 938 Effective length of database: 1,675,806,998 Effective search space: 1571906964124 Effective search space used: 1571906964124 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 137 (57.4 bits)