BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0373.0004.p (205 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value A6LZD4.1 A6LZD4_CLOB8 Putative transcriptional regulator, TetR f... 137 8e-31 B1DCA9.1 B1DCA9_9BACL Transcriptional regulator, TetR family 135 2e-30 Q1AV27.1 Q1AV27_RUBXD Transcriptional regulator, TetR family 127 6e-28 Q5WKD2.1 Q5WKD2_BACSK TetR family transcriptional regulator 115 3e-24 B3KAF7.1 B3KAF7_9BACI Regulatory protein TetR 113 1e-23 >A6LZD4.1 A6LZD4_CLOB8 Putative transcriptional regulator, TetR family Length = 188 Score = 137 bits (344), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 69/187 (36%), Positives = 118/187 (63%), Gaps = 7/187 (3%) Query: 20 VNQEDPRVFRTRQLIREAFRELLQHKGFDAITIKDIAQRATINRATFYAHYEDKYALLDE 79 +N++DPR RT+ LI+E+F +LL+ K F ITIKDI +ATINRATFYAHY DKY LL+E Sbjct: 1 MNEKDPRAIRTKNLIKESFVQLLEEKDFKYITIKDITTKATINRATFYAHYLDKYILLEE 60 Query: 80 IIEQAFLKMIPGQVANAQEFTDETCSQLILMTYRYIVDFYQICRMDSKSIATLVDS---- 135 ++ F +M+P ++ +A + +E +LI Y Y + FYQ ++DS SIA+ VD+ Sbjct: 61 LVIDCFEEMLPIEILSATDLNEEIIKELIFFLYEYNISFYQKRKIDSTSIASTVDNLLKY 120 Query: 136 KIKKMLRQIIESIFMKGDV-HRHARIVSAMTGSAIHGAAHDWLTAGENDRPDLLVDIVRP 194 KI ++ +I+ S+ + ++ + I+ + S+++ A + +ND+ + ++ Sbjct: 121 KIDNLIEKILNSMVARNELDSKDTNILVKLISSSVYSCAQ-YCYFSKNDK-EYNIEKTIS 178 Query: 195 YVMNGLE 201 ++MNG++ Sbjct: 179 FIMNGMK 185 >B1DCA9.1 B1DCA9_9BACL Transcriptional regulator, TetR family Length = 202 Score = 135 bits (340), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 69/183 (37%), Positives = 113/183 (61%), Gaps = 11/183 (6%) Query: 24 DPRVFRTRQLIREAFRELLQHKGFDAITIKDIAQRATINRATFYAHYEDKYALLDEIIEQ 83 DPRV RTR LI+EAF L + K F+AI++KDIA++A+INRATFYAHY DK+ALLD+++ + Sbjct: 8 DPRVIRTRLLIQEAFMALAEQKEFEAISVKDIAEKASINRATFYAHYVDKFALLDDMLTE 67 Query: 84 AFLKMIPGQVANAQEFTDETCSQLILMTYRYIVDFYQICRMDSKSIATLVDSKIKKMLRQ 143 F + ++ Q F +++ QLI + + + FY+ C++D++SIA +V+ K+KK L + Sbjct: 68 RFALLASERIPPGQSFNEDSARQLIALLCEFQILFYKQCKIDTRSIAAVVEDKVKKQLHE 127 Query: 144 IIESIFMK-------GDVHRHARIVSAMTGSAIHGAAHDWLTAGENDRPDLLVDIVRPYV 196 ++ + K G++ A M GS+I+ A W + D ++ + +V Sbjct: 128 MLLQMLQKQAASADIGEIEPAAH----MIGSSIYSATRYWYNNQHSSNADKQIEDMLVFV 183 Query: 197 MNG 199 M+G Sbjct: 184 MSG 186 >Q1AV27.1 Q1AV27_RUBXD Transcriptional regulator, TetR family Length = 198 Score = 127 bits (319), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 67/201 (33%), Positives = 110/201 (54%), Gaps = 8/201 (3%) Query: 7 MMLIDVLKGDGDMVNQEDPRVFRTRQLIREAFRELLQHKGFDAITIKDIAQRATINRATF 66 M++ D + G G +EDPRV RTR+LI AF EL++ KG +T+++IA+RATINRATF Sbjct: 1 MLVKDSVAGGG---RREDPRVRRTRELILRAFAELIEEKGHAGLTVQEIAERATINRATF 57 Query: 67 YAHYEDKYALLDEIIEQAFLKMIPGQVANAQEFTDETCSQLILMTYRYIVDFYQICRMDS 126 YAH+ D+Y L D + +AF K + ++ + ++E+ L+L Y+ CR Sbjct: 58 YAHFRDQYELFDHYVSEAFRKELRRRLPGSPGLSEESLRALVLAACEYLAGLETTCRRKD 117 Query: 127 KSIATLVDSKIKKMLRQII-----ESIFMKGDVHRHARIVSAMTGSAIHGAAHDWLTAGE 181 + L+++++++ L +++ S + G + +++ AI GAA DW G Sbjct: 118 RRFRPLIEARVQRELYELLLGWMEGSPWAAGGRSAAREVTASVVSWAIFGAALDWSRGGT 177 Query: 182 NDRPDLLVDIVRPYVMNGLEL 202 P + D V V+ GL L Sbjct: 178 GCSPAEVADHVLSAVVEGLRL 198 >Q5WKD2.1 Q5WKD2_BACSK TetR family transcriptional regulator Length = 214 Score = 115 bits (288), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 60/185 (32%), Positives = 104/185 (56%), Gaps = 6/185 (3%) Query: 21 NQEDPRVFRTRQLIREAFRELLQHKGFDAITIKDIAQRATINRATFYAHYEDKYALLDEI 80 N+ DPRV RTR+L+++AF L+Q K F++IT+KDIA+RAT+NRATFYAH+ DK+ +L+ Sbjct: 24 NEADPRVIRTRRLLQDAFASLIQEKDFESITVKDIAERATVNRATFYAHFIDKFEILEAR 83 Query: 81 IEQAFLKMIPGQVANAQEFTDETCSQLILMTYRYIVDFYQICRMDSKSIATLVDSKIKKM 140 + ++F+ +I ++ + +ET + L + D +C+ + S+ + +++IK+ Sbjct: 84 LMESFMTIINRRICGHEVLNEETIQSIFLGVCDFHKDLSAMCKRRNASLGAVFETQIKEK 143 Query: 141 LRQIIESIFMKGDVHRHA------RIVSAMTGSAIHGAAHDWLTAGENDRPDLLVDIVRP 194 ++ I+ S K + + S M ++G A+ W G + V P Sbjct: 144 IQTILLSFIDKDKMLSSSNAQFLINTASIMLSWGMYGLAYVWNKEGRQISAESFVKQSMP 203 Query: 195 YVMNG 199 VMNG Sbjct: 204 LVMNG 208 >B3KAF7.1 B3KAF7_9BACI Regulatory protein TetR Length = 196 Score = 113 bits (283), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 60/185 (32%), Positives = 103/185 (55%), Gaps = 6/185 (3%) Query: 21 NQEDPRVFRTRQLIREAFRELLQHKGFDAITIKDIAQRATINRATFYAHYEDKYALLDEI 80 N+ DPRV RTR+L+++AF L+Q K F++IT+KDIA+RAT+NRATFYAH+ DK+ +L+ Sbjct: 6 NEADPRVIRTRRLLQDAFASLIQDKDFESITVKDIAERATVNRATFYAHFVDKFEILEAR 65 Query: 81 IEQAFLKMIPGQVANAQEFTDETCSQLILMTYRYIVDFYQICRMDSKSIATLVDSKIKKM 140 + ++F+ +I +++ + +ET + L + D +C+ S+ + + +IK+ Sbjct: 66 LMESFMTIINRRISGHEVLNEETIQSIFLGVCDFHKDLSTMCKRRYTSLGAVFEIQIKEK 125 Query: 141 LRQIIESIFMKGDVHRHA------RIVSAMTGSAIHGAAHDWLTAGENDRPDLLVDIVRP 194 ++ I+ S K + + M ++GAA+ W G + V P Sbjct: 126 IQTILLSFIDKDKMLSSPNAQFLINTATNMLSWGMYGAAYAWNNEGRLISAESFVKQTMP 185 Query: 195 YVMNG 199 VMNG Sbjct: 186 LVMNG 190 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.325 0.138 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 1,117,562,209 Number of extensions: 40585942 Number of successful extensions: 158569 Number of sequences better than 1.0e-05: 617 Number of HSP's gapped: 158688 Number of HSP's successfully gapped: 617 Length of query: 205 Length of database: 3,060,696,203 Length adjustment: 129 Effective length of query: 76 Effective length of database: 1,845,385,268 Effective search space: 140249280368 Effective search space used: 140249280368 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 128 (53.9 bits)