BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0368.0006.p (428 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KL43.1 B3KL43_9BACI Homoserine dehydrogenase EC=1.1.1.3 650 0.0 B1DDQ0.1 B1DDQ0_9BACL Homoserine dehydrogenase EC=1.1.1.3 590 e-167 C0ZAM2.1 C0ZAM2_BREBN Homoserine dehydrogenase EC=1.1.1.3 477 e-133 C5D737.1 C5D737_9BACI Homoserine dehydrogenase EC=1.1.1.3 452 e-125 A4ISF5.1 A4ISF5_GEOTN Homoserine dehydrogenase EC=1.1.1.3 427 e-118 >B3KL43.1 B3KL43_9BACI Homoserine dehydrogenase EC=1.1.1.3 Length = 428 Score = 650 bits (1677), Expect = 0.0, Method: Compositional matrix adjust. Identities = 326/428 (76%), Positives = 355/428 (82%) Query: 1 MKPXXXXXXXXXXXXXXXXRIVEGNQEDLSSQVGSPILIERIAVKNTDKPRDIEVDAAAI 60 MKP RIVEG+QEDLSSQVGSPI IERIAVK+ +K R + VD + + Sbjct: 1 MKPVKVGLLGLGTVGTGVVRIVEGHQEDLSSQVGSPITIERIAVKHLEKYRSVNVDQSKL 60 Query: 61 TDDPWDVIRDPEIDVIVEVMGGIAGTKEYILEALERGKHIVTANKDLMALHGSEILAKAQ 120 T+DPW VIRDPEIDVIVEVMGGI TK YILEALERGKHIVTANKDLMALHG+EILAKAQ Sbjct: 61 TEDPWAVIRDPEIDVIVEVMGGIEQTKTYILEALERGKHIVTANKDLMALHGAEILAKAQ 120 Query: 121 EKQCDVFYEASVAGGIPIIRTLIEGFSSDKIVKIMGIVNGTTNYILSKMSQEGASYHDVL 180 EKQCDVFYEASVAGGIPIIRTLIEGFSSD+I+KIMGIVNGTTN+IL+KMSQEGASY DVL Sbjct: 121 EKQCDVFYEASVAGGIPIIRTLIEGFSSDRIMKIMGIVNGTTNFILTKMSQEGASYEDVL 180 Query: 181 KEAQELGYAESDPTSDVEGLDAARKMAILGTLGFRTNVELXXXXXXXXXXXXKEDIAFAK 240 EAQELGYAE+DPTSDVEGLDAARKMAILGTLGFRTNVEL K+DIA+AK Sbjct: 181 AEAQELGYAEADPTSDVEGLDAARKMAILGTLGFRTNVELQDVSVKGISQVTKDDIAYAK 240 Query: 241 RLGYEMKLLGIAESHEDEFSISVQPTMIRTGHPIASXXXXXXXXXXXXXXXXETMFYGAG 300 RLGYEMKLLGIAE +DEFSISVQPTM+R GHPIA+ ETMFYGAG Sbjct: 241 RLGYEMKLLGIAERQDDEFSISVQPTMVRKGHPIAAVNGVFNAVYVYGEAVGETMFYGAG 300 Query: 301 AGAMPTATSIVADLVAVIKNLKLGVNGLKQIVPYKQKKLKSDEDIFYKNFLLLHVDDKAG 360 AG MPTATS+VADLVAVIKNLKLGVNGLK IVPYK KKLK+DE I YKNF+LLHVDDKAG Sbjct: 301 AGEMPTATSVVADLVAVIKNLKLGVNGLKAIVPYKPKKLKTDEQIMYKNFILLHVDDKAG 360 Query: 361 VLAKITQVFAEYDVSLDSVVQQANPSNPDAEIIIVTHNASKASMNKVMRHLEQLKVIHRI 420 VLA+ITQVFA+Y+VSL+SVVQQ N NPDAEIIIVTHNASKASM++V+ H E L+VI RI Sbjct: 361 VLAQITQVFAQYNVSLESVVQQPNEHNPDAEIIIVTHNASKASMDEVLNHFEGLEVIRRI 420 Query: 421 KSHYRVEG 428 KS YRVEG Sbjct: 421 KSVYRVEG 428 >B1DDQ0.1 B1DDQ0_9BACL Homoserine dehydrogenase EC=1.1.1.3 Length = 428 Score = 590 bits (1521), Expect = e-167, Method: Compositional matrix adjust. Identities = 291/428 (67%), Positives = 337/428 (78%) Query: 1 MKPXXXXXXXXXXXXXXXXRIVEGNQEDLSSQVGSPILIERIAVKNTDKPRDIEVDAAAI 60 MKP RIVEG+QEDL SQVGSPI+IE+I V+N K R I +DA + Sbjct: 1 MKPVKVGLLGLGTVGTGVVRIVEGHQEDLQSQVGSPIVIEKILVQNKSKARSISIDANKL 60 Query: 61 TDDPWDVIRDPEIDVIVEVMGGIAGTKEYILEALERGKHIVTANKDLMALHGSEILAKAQ 120 T+DPW++I +P+IDVIVEVMGGI TKEYI+EAL RGKH+VTANKDLMALHG EILAKAQ Sbjct: 61 TEDPWEIIGNPDIDVIVEVMGGIGSTKEYIMEALSRGKHVVTANKDLMALHGPEILAKAQ 120 Query: 121 EKQCDVFYEASVAGGIPIIRTLIEGFSSDKIVKIMGIVNGTTNYILSKMSQEGASYHDVL 180 E CDV YEASVAGGIPIIRTL+EGFSSD+I KIMGIVNGTTNYILSKMS EGASY DVL Sbjct: 121 EHGCDVLYEASVAGGIPIIRTLVEGFSSDRITKIMGIVNGTTNYILSKMSLEGASYGDVL 180 Query: 181 KEAQELGYAESDPTSDVEGLDAARKMAILGTLGFRTNVELXXXXXXXXXXXXKEDIAFAK 240 KEAQELGYAE+DPTSDVEGLDAARKM IL TLGFR V L KEDI +AK Sbjct: 181 KEAQELGYAEADPTSDVEGLDAARKMTILATLGFRAKVALEDVSVQGMSKVSKEDILYAK 240 Query: 241 RLGYEMKLLGIAESHEDEFSISVQPTMIRTGHPIASXXXXXXXXXXXXXXXXETMFYGAG 300 RLGYE+KLLGIAE +D+FSISVQPTM++ HPIAS ETMFYG G Sbjct: 241 RLGYEVKLLGIAERQDDQFSISVQPTMVKKSHPIASVNGVYNAVYVYGEAVGETMFYGPG 300 Query: 301 AGAMPTATSIVADLVAVIKNLKLGVNGLKQIVPYKQKKLKSDEDIFYKNFLLLHVDDKAG 360 AG +PTATSIV+DLVAV+KNLKLGVNG + ++ YK+KKLKSDE I K FLLLHVDD+AG Sbjct: 301 AGELPTATSIVSDLVAVVKNLKLGVNGKQSVLTYKEKKLKSDEQISSKYFLLLHVDDRAG 360 Query: 361 VLAKITQVFAEYDVSLDSVVQQANPSNPDAEIIIVTHNASKASMNKVMRHLEQLKVIHRI 420 VLA+ITQ+FAEY+VSL+SV+QQ NP+NPDAEII++TH+A+KA++ KV++ E L VI ++ Sbjct: 361 VLAQITQIFAEYEVSLESVLQQPNPNNPDAEIIVITHDANKAAIQKVLQKFESLDVIRKV 420 Query: 421 KSHYRVEG 428 KS YRVEG Sbjct: 421 KSVYRVEG 428 >C0ZAM2.1 C0ZAM2_BREBN Homoserine dehydrogenase EC=1.1.1.3 Length = 433 Score = 477 bits (1228), Expect = e-133, Method: Compositional matrix adjust. Identities = 236/409 (57%), Positives = 299/409 (73%) Query: 20 RIVEGNQEDLSSQVGSPILIERIAVKNTDKPRDIEVDAAAITDDPWDVIRDPEIDVIVEV 79 RI++ +QEDL Q G I I RI V++ +K R+I +T DP ++ DPEI+VIVEV Sbjct: 22 RIIQAHQEDLQKQTGLSIEISRILVQDAEKSRNISFMEGTLTTDPASLLDDPEIEVIVEV 81 Query: 80 MGGIAGTKEYILEALERGKHIVTANKDLMALHGSEILAKAQEKQCDVFYEASVAGGIPII 139 +GGI KEYIL ALERGKH+VTANKDLMALHG+EIL KAQEK CDVFYEASVAGGIPI+ Sbjct: 82 IGGIHPAKEYILGALERGKHVVTANKDLMALHGAEILEKAQEKGCDVFYEASVAGGIPIL 141 Query: 140 RTLIEGFSSDKIVKIMGIVNGTTNYILSKMSQEGASYHDVLKEAQELGYAESDPTSDVEG 199 R L+EGFSSD+I K+MGIVNGTTNYI++KMSQEGA Y +VLKEAQ LGYAE DPTSDVEG Sbjct: 142 RALVEGFSSDRIAKMMGIVNGTTNYIMTKMSQEGAEYSEVLKEAQALGYAEQDPTSDVEG 201 Query: 200 LDAARKMAILGTLGFRTNVELXXXXXXXXXXXXKEDIAFAKRLGYEMKLLGIAESHEDEF 259 DAARKMAIL TLGFR ++L KEDIA+ K+LGYE+KLLG+A E+ Sbjct: 202 FDAARKMAILATLGFRVPMKLEDVDVKGISSVSKEDIAYGKQLGYEIKLLGLARRDEEAI 261 Query: 260 SISVQPTMIRTGHPIASXXXXXXXXXXXXXXXXETMFYGAGAGAMPTATSIVADLVAVIK 319 +SVQPT++ HP+AS ETMFYG GAG +PTAT++V+DLV V+K Sbjct: 262 EVSVQPTLVPKSHPLASVNGVFNAVYVHGEAVGETMFYGPGAGELPTATAVVSDLVTVVK 321 Query: 320 NLKLGVNGLKQIVPYKQKKLKSDEDIFYKNFLLLHVDDKAGVLAKITQVFAEYDVSLDSV 379 N KLGVNG + PYK+K LK D + F K FL + V DK GVLA+ITQ+ A+ ++SL+ V Sbjct: 322 NRKLGVNGRGMVAPYKEKVLKEDSEKFSKYFLRIVVADKRGVLAQITQLLADKNISLEQV 381 Query: 380 VQQANPSNPDAEIIIVTHNASKASMNKVMRHLEQLKVIHRIKSHYRVEG 428 +QQ + +AEII++TH +SK+ M+ V+ ++ Q+ ++ ++S YRVEG Sbjct: 382 IQQPFNNGREAEIIMITHMSSKSDMDAVLAYMAQMDIVSTVQSCYRVEG 430 >C5D737.1 C5D737_9BACI Homoserine dehydrogenase EC=1.1.1.3 Length = 432 Score = 452 bits (1162), Expect = e-125, Method: Compositional matrix adjust. Identities = 218/409 (53%), Positives = 296/409 (72%) Query: 20 RIVEGNQEDLSSQVGSPILIERIAVKNTDKPRDIEVDAAAITDDPWDVIRDPEIDVIVEV 79 +I+E +QE L QVG P+ I++I V++ K RD+ V+ + +T + DVI DPEIDVI+EV Sbjct: 21 KIIENHQERLMHQVGCPVQIKKILVRDIYKKRDVRVEPSLLTTNVTDVIDDPEIDVIIEV 80 Query: 80 MGGIAGTKEYILEALERGKHIVTANKDLMALHGSEILAKAQEKQCDVFYEASVAGGIPII 139 MGGI T++Y+L AL +GKH+VTANKDLMAL+GSE+LA A E CD+FYEASVAGGIPI+ Sbjct: 81 MGGIEETRQYLLRALRQGKHVVTANKDLMALYGSELLAVAVENHCDLFYEASVAGGIPIL 140 Query: 140 RTLIEGFSSDKIVKIMGIVNGTTNYILSKMSQEGASYHDVLKEAQELGYAESDPTSDVEG 199 R+L++G +SD+I K+MGIVNGTTNYIL+KM + G+SY +VL EAQ LGYAE+DPT+DVEG Sbjct: 141 RSLVDGLASDRITKMMGIVNGTTNYILTKMCKYGSSYEEVLAEAQALGYAEADPTADVEG 200 Query: 200 LDAARKMAILGTLGFRTNVELXXXXXXXXXXXXKEDIAFAKRLGYEMKLLGIAESHEDEF 259 LDAARKMAIL LGF N++L +ED+ ++KRLGY MKL+GIA+ ++ Sbjct: 201 LDAARKMAILARLGFSMNIDLDDVQVKGITSITEEDLNYSKRLGYTMKLIGIAKRDGNKV 260 Query: 260 SISVQPTMIRTGHPIASXXXXXXXXXXXXXXXXETMFYGAGAGAMPTATSIVADLVAVIK 319 +SVQPT++ HP+AS ETMFYG GAG++PTAT++V+DLVAV+K Sbjct: 261 EVSVQPTLLPDSHPLASVNDEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMK 320 Query: 320 NLKLGVNGLKQIVPYKQKKLKSDEDIFYKNFLLLHVDDKAGVLAKITQVFAEYDVSLDSV 379 N++LGVNG + P +K+LKS +IF K FL +HV D+ G AKIT +F+E VS + + Sbjct: 321 NMRLGVNGCNAVAPQYEKQLKSASEIFSKYFLRIHVKDQVGAFAKITALFSERGVSFEKI 380 Query: 380 VQQANPSNPDAEIIIVTHNASKASMNKVMRHLEQLKVIHRIKSHYRVEG 428 +Q + AEI+IVTH AS+ +++ L L+++H +KS YRVEG Sbjct: 381 LQLPLKEDGLAEIVIVTHRASQKDYEDILQQLRDLEIVHEVKSSYRVEG 429 >A4ISF5.1 A4ISF5_GEOTN Homoserine dehydrogenase EC=1.1.1.3 Length = 432 Score = 427 bits (1099), Expect = e-118, Method: Compositional matrix adjust. Identities = 218/409 (53%), Positives = 296/409 (72%) Query: 20 RIVEGNQEDLSSQVGSPILIERIAVKNTDKPRDIEVDAAAITDDPWDVIRDPEIDVIVEV 79 +I+E +QE L QVG P+ +++I V++ KPR++ VD+A +T DVI DP+IDVI+EV Sbjct: 21 KIIENHQEKLIHQVGCPVKVKKILVRDVQKPREVAVDSALLTTSAADVIDDPDIDVIIEV 80 Query: 80 MGGIAGTKEYILEALERGKHIVTANKDLMALHGSEILAKAQEKQCDVFYEASVAGGIPII 139 MGGI TKE +L AL +GKH+VTANKDLMA++GSE+L A E CD+FYEASVAGGIPI+ Sbjct: 81 MGGIEETKELLLRALRQGKHVVTANKDLMAVYGSELLRVAAEHHCDLFYEASVAGGIPIL 140 Query: 140 RTLIEGFSSDKIVKIMGIVNGTTNYILSKMSQEGASYHDVLKEAQELGYAESDPTSDVEG 199 R+L++G +SD+I K+MGIVNGTTNYIL+KMSQ GASY +VL EAQ LG+AE+DPTSDVEG Sbjct: 141 RSLVDGLASDRITKMMGIVNGTTNYILTKMSQNGASYQEVLAEAQALGFAEADPTSDVEG 200 Query: 200 LDAARKMAILGTLGFRTNVELXXXXXXXXXXXXKEDIAFAKRLGYEMKLLGIAESHEDEF 259 LDAARKMAIL LGF +++L +ED+ + KRLGY MKL+GIA+ + ++ Sbjct: 201 LDAARKMAILARLGFSMDIDLDDVQVKGITHVTEEDLNYGKRLGYTMKLIGIAQRNGNKV 260 Query: 260 SISVQPTMIRTGHPIASXXXXXXXXXXXXXXXXETMFYGAGAGAMPTATSIVADLVAVIK 319 +SVQPT + HP+AS ETMFYG GAG++PTAT++V+DLVAV+K Sbjct: 261 EVSVQPTFLPDSHPLASVHNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMK 320 Query: 320 NLKLGVNGLKQIVPYKQKKLKSDEDIFYKNFLLLHVDDKAGVLAKITQVFAEYDVSLDSV 379 N++LGVNG + P +K+LK+ +IF K FL +HV D+ G AKIT +F+E VS + + Sbjct: 321 NMRLGVNGHYAVAPQYEKQLKAPAEIFSKYFLRIHVKDQVGAFAKITTLFSERGVSFEKI 380 Query: 380 VQQANPSNPDAEIIIVTHNASKASMNKVMRHLEQLKVIHRIKSHYRVEG 428 +Q N AEI+IVTH+AS+ +++ L L+++ R++S YRVEG Sbjct: 381 LQLPLKENGLAEIVIVTHDASQQDYEDILQQLSDLEIVERVQSSYRVEG 429 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.316 0.134 0.367 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,130,033,953 Number of extensions: 81345500 Number of successful extensions: 234891 Number of sequences better than 1.0e-05: 1797 Number of HSP's gapped: 230953 Number of HSP's successfully gapped: 1798 Length of query: 428 Length of database: 3,060,696,203 Length adjustment: 139 Effective length of query: 289 Effective length of database: 1,751,175,118 Effective search space: 506089609102 Effective search space used: 506089609102 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 133 (55.8 bits)