BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0350.0042.p (620 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KK08.1 B3KK08_9BACI Histidine kinase internal region 828 0.0 B1D770.1 B1D770_9BACL Integral membrane sensor signal transducti... 457 e-126 B3KA48.1 B3KA48_9BACI Histidine kinase internal region 262 1e-67 C5EKG5.1 C5EKG5_9FIRM Histidine kinase internal region 223 6e-56 B3K5A3.1 B3K5A3_9BACI Histidine kinase internal region 208 1e-51 >B3KK08.1 B3KK08_9BACI Histidine kinase internal region Length = 620 Score = 828 bits (2139), Expect = 0.0, Method: Compositional matrix adjust. Identities = 393/623 (63%), Positives = 504/623 (80%), Gaps = 8/623 (1%) Query: 1 MNLRYKLFTAXXXXXXXXXXXXXXXXXXVTYNSIEKKYSQQSEYSLKAISYSISSVFKDM 60 MNLR KLFTA +TYNSIE+KYSQQ+EYSLKAISYSI +VFK+M Sbjct: 3 MNLRNKLFTAFLGLIIIPLFVLGLFTFFITYNSIEEKYSQQAEYSLKAISYSILNVFKEM 62 Query: 61 DNVTDNGIATSVFHMALSAEDPSKQDL---TDAEQLSLNASQRNFRSLLYNHPSISYAFL 117 + VTDNGIATSVF MAL+A+DP Q+L ++A+QL LN QR+FR+LLYNHP+ISYAFL Sbjct: 63 EYVTDNGIATSVFAMALNAKDPDAQNLIKESNADQLKLNDRQRSFRNLLYNHPAISYAFL 122 Query: 118 YNFNGKGSSEIVSVFNKENFRTLPYDKFKGSELYQEVMELNGVPKWLAPHEYPELTGTEP 177 Y+FN + + + +F+KE+FRTLPY++FK S LY+EV++LNG+PKWLAPHE+PELTG +P Sbjct: 123 YHFNKESAP--IPIFSKEDFRTLPYEQFKNSPLYEEVVKLNGIPKWLAPHEFPELTGADP 180 Query: 178 VFTQIRLVKELSFFQNIGILVVQIKNWEFESIFRNLKIGDSGQKVSFMLVNDDGMILFDP 237 VFTQIRL+K+++ + +GILVVQIK WEFE IFRNL + ++ Q SFMLVN++G ILFDP Sbjct: 181 VFTQIRLIKDVTTLRKLGILVVQIKRWEFEEIFRNLTLPNNLQNTSFMLVNNEGFILFDP 240 Query: 238 DRKLDGQDFRSFTNKKFAFQKGFQSFKTEFAGEKSILSVYHLKDYPWSLVSVTSWDSLSR 297 +DGQ+ + + F++G+QSFK +F G+++I+S+YHL DY W++VSVT W+SLS+ Sbjct: 241 QNGMDGQNISQYMKRDVEFKQGYQSFKAKFNGKENIVSIYHLNDYGWNIVSVTDWNSLSQ 300 Query: 298 EVTVFARWFVVVIFLCLLGAVIFNLFFMNRITGGIAVIVRFMRRVEDGDLTTRVEEKGSD 357 EVT FA+WF V++ +CL+ A++FN FMNRITG IAVIVRFMRRVEDGDL RVEEKG D Sbjct: 301 EVTSFAKWFFVIMGICLVTAIVFNRLFMNRITGTIAVIVRFMRRVEDGDLNARVEEKGED 360 Query: 358 EMTLLAKGFNDLMDKINSLFNRVHVEQRRKNQAEMRVLQAQIKPHFLFNTLESINVLAVQ 417 E+ LL+KGFN+LM++IN+LF ++ EQR+K AEMRVLQAQIKPHFLFNTLESINVLAVQ Sbjct: 361 ELLLLSKGFNNLMNRINNLFAQIKKEQRQKTDAEMRVLQAQIKPHFLFNTLESINVLAVQ 420 Query: 418 NEGRKVSEMVYRLASILRISIQDRDEITLEEEVTHLRNYLDIQKFRFEDVFDYEIEIPQE 477 NEGRKVSEMVYRLASILRISIQD++EITL+EE+ HL++YL+IQKFRFED+F+YEI++P+E Sbjct: 421 NEGRKVSEMVYRLASILRISIQDKEEITLDEEIKHLQSYLEIQKFRFEDLFEYEIDVPKE 480 Query: 478 LMGCGILKLTLQPLVENSIQHGFEGIDYKGLVRVKGWENRGNLILQIQDNGIGMTSAQLG 537 LM ILKLTLQPLVENSIQHGFEGI Y G +R+ W+ GN++++++DNG+GMTS QL Sbjct: 481 LMHSRILKLTLQPLVENSIQHGFEGISYTGWIRISAWKELGNVVIRVEDNGLGMTSEQLS 540 Query: 538 MFQYMVGESGESAERNSGDITGHGIHLERRGLGVRSVADRIRIEYGDRYGIFICASPGEG 597 MF+YMV E G + ++ ++ ERRGLG+RSVADR+RI+YG YG+FIC+S G Sbjct: 541 MFEYMVSEDGVPDQTTLQNLK---VNQERRGLGLRSVADRLRIQYGPYYGLFICSSRPGG 597 Query: 598 TIIQCVIPKYGQGEDHYAKSIIG 620 T+IQCVIP Y +GE +A+ IIG Sbjct: 598 TVIQCVIPNYDRGEGQHAEGIIG 620 >B1D770.1 B1D770_9BACL Integral membrane sensor signal transduction histidine kinase Length = 606 Score = 457 bits (1175), Expect = e-126, Method: Compositional matrix adjust. Identities = 245/612 (40%), Positives = 359/612 (58%), Gaps = 18/612 (2%) Query: 1 MNLRYKLFTAXXXXXXXXXXXXXXXXXXVTYNSIEKKYSQQSEYSLKAISYSISSVFKDM 60 MNLR KL A T + +EKKYS+Q+E SLKA+ +I FK++ Sbjct: 1 MNLRPKLMLAFIFLVVVPMIGLGIVSFLNTESVLEKKYSEQTEISLKAVGGNIKYFFKEL 60 Query: 61 DNVTDNGIATSVFHMALSAEDPSKQDLTDAEQL-SLNASQRNFRSLLYNHPSISYAFLYN 119 D ++D + +S L+ D DA L ++N S++ + +L+ HP++S+ LY Sbjct: 61 DQLSDGNLTSSEVQDTLNYSKYYSSD--DASTLIAINQSEKEMKRILFQHPAVSFVVLYA 118 Query: 120 FNGKGSSEIVSVFNKE--NFRTLPYDKFKGSELYQEVMELNGVPKWLAPHEYPELTGTEP 177 +G + F + FR + ++ K LY E ++L G PKW+ P+E+ ELTG EP Sbjct: 119 MDGT----MFRAFRNDPTTFRPIAFEALKDQPLYNETIKLGGRPKWIGPYEHQELTGVEP 174 Query: 178 -VFTQIRLVKELSFFQNIGILVVQIKNWEFESIFRN-LKIGDSGQKVSFMLVNDDGMILF 235 +FTQ+RLVK+ ++G+++ Q K E S+ L G +++VN +G+++ Sbjct: 175 PLFTQLRLVKDYETLADLGLMITQYKTEEVYSMLNTFLNPEAEGPNSRYVIVNSEGLVML 234 Query: 236 DPDRKLDGQDFRSFTNKKFAFQKGFQSFKTEFAGEKSILSVYHLKDYPWSLVSVTSWDSL 295 D + +G + +++ + S + F GE S++S Y+L W LVSV SWD L Sbjct: 235 DSGKHFEGTNISEYSSALPQNTADYSSARLRFNGEDSLVSSYNLGFNDWVLVSVKSWDML 294 Query: 296 SREVTVFARWFVVVIFLCLLGAVIFNLFFMNRITGGIAVIVRFMRRVEDGDLTTRVEEKG 355 + E F +W ++ LC+L A++FN+FF+NR+ I +VR MR VE G L RV +G Sbjct: 295 TNENERFVQWIGMITILCILSAILFNIFFVNRVAKSIIKVVRKMRLVEQGLLDIRVNAQG 354 Query: 356 SDEMTLLAKGFNDLMDKINSLFNRVHVEQRRKNQAEMRVLQAQIKPHFLFNTLESINVLA 415 DE LLA FN ++ +I L V EQ RK AEM ++QAQIKPHFLFNTLESIN LA Sbjct: 355 KDETVLLANSFNSMVQRIGDLLTEVRTEQERKQHAEMMLMQAQIKPHFLFNTLESINALA 414 Query: 416 VQNEGRKVSEMVYRLASILRISIQDRDEITLEEEVTHLRNYLDIQKFRFEDVFDYEIEIP 475 QNEG K+ MV RL+++LR S+ +EI L +E+ H+R+YL+IQK+RFED+F YE+ + Sbjct: 415 AQNEGGKIMMMVRRLSNLLRTSMHHSEEIFLSQEIEHVRSYLEIQKYRFEDLFTYELNVS 474 Query: 476 QELMGCGILKLTLQPLVENSIQHGFEGI-DYKGLVRVKGWENRGNLILQIQDNGIGMTSA 534 +E ILKLTLQPLVENSIQHGFEG+ D G++ ++ +++ + DNG GM Sbjct: 475 EEAFEYSILKLTLQPLVENSIQHGFEGLEDGAGMITIEVTVEAHQIVILVSDNGHGMNEQ 534 Query: 535 QLGMFQYMVGESGESAERNSGDITGHGIHLERRGLGVRSVADRIRIEYGDRYGIFICASP 594 L F RN+ ++ ERRGLG+R+VADR+RI YG YG+ IC++ Sbjct: 535 TLKKFAEREQPLPSGKRRNAAELG------ERRGLGLRNVADRLRIHYGPSYGLRICSAE 588 Query: 595 GEGTIIQCVIPK 606 G GT+I+C IPK Sbjct: 589 GYGTVIRCTIPK 600 >B3KA48.1 B3KA48_9BACI Histidine kinase internal region Length = 574 Score = 262 bits (669), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 173/549 (31%), Positives = 282/549 (51%), Gaps = 50/549 (9%) Query: 70 TSVFHMALSAEDPSKQDLTDAEQLSLNASQRNFRSLLYNHPSI-SYAFLYN----FNGKG 124 T++ + A++ + S Q + + ++ +R + L NHP I S+AF N +N G Sbjct: 61 TTISNSAITQQ--SVQQMLKQPEYAVTYERRQEINNLINHPMIASFAFYSNDRLMYNTNG 118 Query: 125 SSEIVSVFNKENFRTLPYDKFKGSELYQEVMELNGVPKWLAPHEYPELTGTEPVFTQIRL 184 E+ + + Y+ V + G P W+ P E PV Q R+ Sbjct: 119 GMEL--------------QELRQQAWYEAVEKAEGRPVWVGPGENGSAADGAPVLIQSRV 164 Query: 185 VKELSFFQNIGILVVQIKNWEFESIF---RNLKIGDSGQKVSFMLVNDDGMILFDPDRKL 241 +K+ ++IG +V+ +K + +F LK GD +LVN G I+F Sbjct: 165 IKDYYSLEDIGTVVIYVKPDLLDQVFWEAATLKQGD------ILLVNQQGHIVFSKSGGH 218 Query: 242 DGQ--DFRSFTNKKFAFQKGFQSFKTEFAGEKSILSVYHLKDYPWSLVSVTSWDSLSREV 299 G+ +F ++ KG+ + ++AGEKS+++ + W LV++T +S E Sbjct: 219 IGERTEFPFLSDSYKTNGKGY--YIDQYAGEKSLITYSPSHNKDWFLVAITPSKLISAES 276 Query: 300 TVFARWFVVVIFLCLLGAVIFNLFFMNRITGGIAVIVRFMRRVEDGDLTTRVEEK-GSDE 358 +++ + L+ A +F+ FF+ R+ I V M+RV+ G DE Sbjct: 277 VPIRNLALILGLISLVSAFLFDRFFVRRMVRSIISAVNGMKRVKQGIFVPIPSHNVAEDE 336 Query: 359 MTLLAKGFNDLMDKINSLFNRVHVEQRRKNQAEMRVLQAQIKPHFLFNTLESINVLAVQN 418 LL GFN + +I L +V EQ RK +AE++ L AQI PHF++N+LESIN +AV Sbjct: 337 TDLLIDGFNRMSTQIQELIGQVETEQARKKEAELQALVAQINPHFIYNSLESINSMAVLQ 396 Query: 419 EGRKVSEMVYRLASILRISIQDRDE-ITLEEEVTHLRNYLDIQKFRFEDVFDYEIEIPQE 477 + +S+MV L +LRISI + E I L E+ H+++Y+ IQKFRFE+ FDY IE+P E Sbjct: 397 GNKDISKMVISLGKLLRISISEHHELIPLSMELEHVQHYMRIQKFRFEEKFDYGIELPNE 456 Query: 478 LMGCGILKLTLQPLVENSIQHGFEGIDYKGLVRVKGWENRGNLILQIQDNGIGMTSAQLG 537 L KL +QP+VEN++ HG E ++ GL+ +K EN ++++ ++DNG G L Sbjct: 457 LRHYVTQKLIVQPIVENALYHGIEPMEESGLISIKVSENGEDIVIDVEDNGPGFDPETLM 516 Query: 538 MFQYMVGESGESAERNSGDITGHGIHLERRGLGVRSVADRIRIEYGDRYGIFICASPGEG 597 + G + + G+G+++V +R+RI +G RYG+ IC+SPG G Sbjct: 517 KLW----------NSDPGQLKKY----RENGVGLKNVHERLRIRFGSRYGLMICSSPGYG 562 Query: 598 TIIQCVIPK 606 ++I+ IPK Sbjct: 563 SLIRIRIPK 571 >C5EKG5.1 C5EKG5_9FIRM Histidine kinase internal region Length = 597 Score = 223 bits (567), Expect = 6e-56, Method: Compositional matrix adjust. Identities = 167/585 (28%), Positives = 289/585 (49%), Gaps = 52/585 (8%) Query: 39 SQQSEYSLKAISYSISSVFKDMDNVTDNGIATSVFHMALSAEDPS-----KQDLTDAEQL 93 S S Y L A S + + + ++ TD ++ + +++ED ++ L D ++ Sbjct: 40 SMNSVYRLTADS--VGNSLRQINIDTDRALSDAQHMAEVTSEDSDIQKALRRPLPDTDK- 96 Query: 94 SLNASQRNFRSLLY----NHPSISYAFLYNFNGKGSSEIVSVFNKENFRTLPYDKFKGSE 149 + + NF + LY + +I+ ++ NG S+ +KE +R P+ Sbjct: 97 EIYKERINFNNSLYYTWRSSENINGIYVLGANGAIFRSYYSL-HKEEYRDEPW------- 148 Query: 150 LYQEVMELNGVPKWLAPHEYPELTGTEPVFTQIRLVKELSFFQNIGILVVQIKNWEFESI 209 ++ VME G P W+ PHE + + T I ++ + + IL V + + + Sbjct: 149 -FRTVME-TGKPLWMEPHEGSSVANNLNLLT-ISIIVPIHDKASTDILGVTV----VDVL 201 Query: 210 FRNLKIGDSGQKV---SFMLVNDDGMILFDPDRKLDGQDFRSFTNKKFAFQKGFQ---SF 263 +LK G+ V + ++N+D I++ + +L +D + N A Q + Sbjct: 202 VEDLKSIQDGEMVFGGNTFILNEDDRIIYANNDELSEEDIGTI-NASIAGQDSLHEGDAL 260 Query: 264 KTEFAGEKSILSVYHLKDYPWSLVSVTSWDSLSREVTVFARWFVVVIFLCLLGAVIFNLF 323 + G K + + L D W ++ + S+ + E V R ++V + GA +F + Sbjct: 261 ELNIGGRKYLGELIPLSDRNWKILGLISYKDMYAEAQVM-RNTILVFIVFFGGASLFMAW 319 Query: 324 F-MNRITGGIAVIVRFMRRVEDGDLTTRVEEKGSDEMTLLAKGFNDLMDKINSLFNRVHV 382 F I G + ++ MR+VEDGD + R+EE DE+ L GFN ++ K++ L R Sbjct: 320 FGAKNIAGPLGRVLDGMRKVEDGDFSVRIEEDRKDEIGDLIHGFNHMVYKVDDLMARERD 379 Query: 383 EQRRKNQAEMRVLQAQIKPHFLFNTLESINVLAVQNEGRKVSEMVYRLASILRISI-QDR 441 +++ QAE LQ QIKPHFL+NTL+SIN +A N KVSEM+ L LRI + + + Sbjct: 380 TRQKLVQAEFNALQDQIKPHFLYNTLDSINWMARMNRTDKVSEMIDSLTGFLRIGLSRGK 439 Query: 442 DEITLEEEVTHLRNYLDIQKFRFEDVFDYEIEIPQELMGCGILKLTLQPLVENSIQHGFE 501 D I+L EE+ H+ +Y+ IQK R++ + DY+I++ ++LMG ++K+ LQPLVEN+I HG + Sbjct: 440 DFISLAEEIRHVESYISIQKIRYDRILDYKIDVSEDLMGYRVIKMILQPLVENAIYHGIK 499 Query: 502 GIDYKGLVRVKGWENRGNLILQIQDNGIGMTSAQLGMFQYMVGESGESAERNSGDITGHG 561 D G + + G E L+L + D+G+GM +L + M+ G Sbjct: 500 EKDEHGTITITGEETEDRLVLCVSDDGLGMKPERLAQIRAMMAS---------------G 544 Query: 562 IHLERRGLGVRSVADRIRIEYGDRYGIFICASPGEGTIIQCVIPK 606 GV +V RI+ +G+ YG+ + +GT + +PK Sbjct: 545 ARYNDNAYGVINVQRRIQAYFGEEYGLDFRSEYTKGTQVYITLPK 589 >B3K5A3.1 B3K5A3_9BACI Histidine kinase internal region Length = 592 Score = 208 bits (529), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 153/590 (25%), Positives = 286/590 (48%), Gaps = 48/590 (8%) Query: 34 IEKKYSQQSEYSLKAISYSISSVFKDMDNVTDNGIATSVFHMALSAEDPSKQDLTDAEQL 93 +E++ S+ + ++ +S ++ FK +D+ + + + V H L +D SK DLT L Sbjct: 41 VEEQVSKVASLTITQVSDKLNMFFKKLDDSSMMVLNSKVVHGILEDQDISKYDLT----L 96 Query: 94 SLNASQRNFRSLLYNHPSISYAFLYNFNGKGSSEIVSVFNKENFRTLPYDKFKGSELYQE 153 + + S++ N P I ++++ S V + ++ ++P D++ S Y+ Sbjct: 97 KVKEGKDLLTSIMINSPEILDVYVFDVQRNNS-----VLSADSLMSIP-DQWD-SPWYRA 149 Query: 154 VMELNGVPKW--LAPHEYPELTGTE-PVFTQIRLVKELSFFQNIGILVVQIKNWEFESIF 210 ++E NG W L+ Y + TG PVF R ++ + +G++ ++I Sbjct: 150 ILEANGQAVWFGLSDTSYLKQTGMGFPVFGLGRAIRSWDTGEIVGVMFIEIMGDVLIDEL 209 Query: 211 RNLKIGDSGQKVSFMLV-NDDGMILFDPDRKLDGQDFRSFTNKKFAFQKGFQSFKTEFAG 269 +++ GD+G +M V ND+ + PD + G+ R G + Sbjct: 210 NHVQFGDTG----YMYVANDENRYFYHPDPSMYGKQSR------IKLPSGLTEYN--LNN 257 Query: 270 EKSILSVYHLKDYPWSLVSVTSWDSLSREVTVFARWFVVVIFLCLLGAVIFNLFFMNRIT 329 K+++ L + W +V + L+ + + V ++F +L A+ F RI Sbjct: 258 NKTLMIPSRLNN-GWHVVGMVPLKELTADSASIRSFTVWIVFGSILAAIGIGYFMTRRIG 316 Query: 330 GGIAVIVRFMRRVEDGDLTTRVEEKGSDEMTLLAKGFNDLMDKINSLFNRVHVEQRRKNQ 389 + + R MRR E GDL+ R + G E+ L + FN ++++I+ L R+ E+ K + Sbjct: 317 NPLVQLSRLMRRSEAGDLSVRSKNVGPSEIGQLGRSFNKMIEQIDLLIRRIAAEESEKKK 376 Query: 390 AEMRVLQAQIKPHFLFNTLESINVLAVQNEGRKVSEMVYRLASILRISIQDRDE-ITLEE 448 AE+R L+ QI PHFL+NTL SI +A N V V L +L S++ I L + Sbjct: 377 AEIRALRYQINPHFLYNTLNSIRWMAKLNRTNDVDRSVTALVHLLEGSLERNGVFIRLGD 436 Query: 449 EVTHLRNYLDIQKFRFEDVFDYEIEIPQELMGCGILKLTLQPLVENSIQHGFEGIDYKGL 508 E+ LR Y+ IQ +R++ + I+ P+E+ + ++ LQP+VEN+I HG +D G+ Sbjct: 437 ELELLRKYMIIQNYRYDHPIELRIDCPEEMEDLHVPRMLLQPIVENAIFHGIAPLDEGGV 496 Query: 509 VRVKGWENRGNLILQIQDNGIGMTSAQL-GMFQYMVGESGESAERNSGDITGHGIHLERR 567 ++++ + +++++I+DNGIG+ ++ G+ Y S + Sbjct: 497 IQIRITLQQQDVMVRIEDNGIGIKPERIKGLLSYEQDHSKQGMTH--------------- 541 Query: 568 GLGVRSVADRIRIEYGDRYGIFICASPGEGTIIQCVIPKYGQGEDHYAKS 617 +G+R V +++ YG RYG+++ ++ G GT + K Q D Y +S Sbjct: 542 -IGLRHVHQTVQLYYGSRYGVWVESTEGGGTRVTVTFAK--QRGDDYVQS 588 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.321 0.138 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,469,074,246 Number of extensions: 148008990 Number of successful extensions: 381304 Number of sequences better than 1.0e-05: 2158 Number of HSP's gapped: 378208 Number of HSP's successfully gapped: 2159 Length of query: 620 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 478 Effective length of database: 1,722,912,073 Effective search space: 823551970894 Effective search space used: 823551970894 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 134 (56.2 bits)