BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0346.0011.p (474 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Q3Y3F9.1 Q3Y3F9_ENTFC Glucuronate isomerase EC=5.3.1.12 647 0.0 C2H7R1.1 C2H7R1_ENTFC Glucuronate isomerase EC=5.3.1.12 642 0.0 C1P818.1 C1P818_BACCO Glucuronate isomerase EC=5.3.1.12 597 e-168 Q2B7Q3.1 Q2B7Q3_9BACI Glucuronate isomerase EC=5.3.1.12 557 e-156 Q65F21.1 UXAC_BACLD Uronate isomerase EC=5.3.1.12 553 e-155 >Q3Y3F9.1 Q3Y3F9_ENTFC Glucuronate isomerase EC=5.3.1.12 Length = 464 Score = 647 bits (1669), Expect = 0.0, Method: Compositional matrix adjust. Identities = 303/465 (65%), Positives = 358/465 (76%), Gaps = 1/465 (0%) Query: 1 MFLNDDFLLTSETARLLFHNHAKTMPIIDYHCHLDPKEIYEDKAFRNLTEAWLAGDHYKW 60 MFL+DDFLL + A+ L+H++AK MPIIDYHCHLDPKEIYE+ F NLTEAWL GDHYKW Sbjct: 1 MFLSDDFLLKDDWAKKLYHSYAKNMPIIDYHCHLDPKEIYENNNFSNLTEAWLGGDHYKW 60 Query: 61 RLMRANGIPESHITGEASDYDKFLAWARTLPKAVGNPLYSWTHLELRRFFGINETLNEAS 120 RLMRA G+PE ITG ASD++KFLAW +T+PK +GNPLYSW+HLEL+RFFGI+ +NE + Sbjct: 61 RLMRACGVPEEKITGNASDFEKFLAWCQTVPKIIGNPLYSWSHLELKRFFGIDLLINEEN 120 Query: 121 APAIWEEVNRKLAEPAYTRRSLIRNSKVKTVCTTDDPADSLEYHRLLKESEQDFQVFPTF 180 A IW + N LA P + RR + + S V+ +CTTDDPAD L YH+LL E D +V P+F Sbjct: 121 AEKIWTQANEILAAPDFRRREIAKKSNVEVICTTDDPADDLHYHQLLAHEEPDLKVLPSF 180 Query: 181 RPDKALNIDADGFTTWLTRLGEAAGVAVTTYAALVEALRSRVDFFHQNGCRLSDHALDVL 240 RPDKALNI+ +GF W+T L EAA +TTY L+E L R+++FHQ+GCR+SDHALD+L Sbjct: 181 RPDKALNIEKEGFNAWVTLLEEAADQTITTYQELIEVLGQRIEYFHQHGCRVSDHALDIL 240 Query: 241 RYQAAGEASQLERIFTKRLEGAVLSPEEITVYRTELLSELIGMYHDKNWTMQLHLHAFRN 300 RY+ A E + LE IF K +LS +EI YRTE L L YH NWTMQLH+HA+RN Sbjct: 241 RYKEADE-TVLEEIFQKARANKLLSSDEIDAYRTETLIHLTHFYHSHNWTMQLHIHAYRN 299 Query: 301 NNTPMFRRLGPDTGYDGINDLSLAEALSQLLDRAECGKGLPKTILYSLNPGDYPALLALM 360 NT M +LGPDTGYDG+NDLSL L +LL+RAE LPKTILYSLNP DYPA+LALM Sbjct: 300 CNTQMLEKLGPDTGYDGMNDLSLTIPLQKLLNRAEETDQLPKTILYSLNPNDYPAILALM 359 Query: 361 GCYQKDTAGKLQLGSGWWYNDTRDGMRRQLTLLADNSLLGNFVGMLTDSRSFLSYTRHEY 420 GC+QK+ GKLQLGSGWWYNDTR GMR QLT AD S LGNFVGMLTDSRSFLSYTRHEY Sbjct: 360 GCFQKEQNGKLQLGSGWWYNDTRAGMRDQLTQFADGSALGNFVGMLTDSRSFLSYTRHEY 419 Query: 421 FRRVLCELLGELADRGEAPDDLALLGQLVEDIAYNNAAGYFGFEA 465 FRRVLCE LGE+ RGEAP+D LLG LV+ I+Y NA YFGF A Sbjct: 420 FRRVLCEFLGEMVMRGEAPEDEQLLGSLVQAISYTNAKNYFGFFA 464 >C2H7R1.1 C2H7R1_ENTFC Glucuronate isomerase EC=5.3.1.12 Length = 478 Score = 642 bits (1655), Expect = 0.0, Method: Compositional matrix adjust. Identities = 301/465 (64%), Positives = 355/465 (76%), Gaps = 1/465 (0%) Query: 1 MFLNDDFLLTSETARLLFHNHAKTMPIIDYHCHLDPKEIYEDKAFRNLTEAWLAGDHYKW 60 MFL+DDFLL + A+ L+H++AK MPIIDYHCHLDPKEIYE+ F NLTEAWL GDHYKW Sbjct: 15 MFLSDDFLLKDDWAKNLYHSYAKNMPIIDYHCHLDPKEIYENNNFSNLTEAWLGGDHYKW 74 Query: 61 RLMRANGIPESHITGEASDYDKFLAWARTLPKAVGNPLYSWTHLELRRFFGINETLNEAS 120 RLMRA G+PE ITG ASD++KFLAW +T+PK +GNPLYSW+HLEL+RFF I+ +NE + Sbjct: 75 RLMRACGVPEEKITGNASDFEKFLAWCQTVPKIIGNPLYSWSHLELKRFFDIDLLINEEN 134 Query: 121 APAIWEEVNRKLAEPAYTRRSLIRNSKVKTVCTTDDPADSLEYHRLLKESEQDFQVFPTF 180 A IW + N LA P + RR + + S V+ +CTTDDPAD L YH+LL E D +V P+F Sbjct: 135 AEKIWTQANEILASPDFRRREIAKKSNVEVICTTDDPADDLHYHQLLAHEEPDLKVLPSF 194 Query: 181 RPDKALNIDADGFTTWLTRLGEAAGVAVTTYAALVEALRSRVDFFHQNGCRLSDHALDVL 240 RPDKALNI+ +GF W+T L EAA +TTY L+E L R+++FHQ+GCR+SDHALD L Sbjct: 195 RPDKALNIEKEGFNAWITLLEEAADQTITTYQELIEVLGQRIEYFHQHGCRVSDHALDTL 254 Query: 241 RYQAAGEASQLERIFTKRLEGAVLSPEEITVYRTELLSELIGMYHDKNWTMQLHLHAFRN 300 RY+ A E + LE IF K +LS +EI YRTE L L YH NWTMQLH+HA+RN Sbjct: 255 RYKEADE-TVLEEIFQKARANKLLSSDEIDAYRTETLIRLTHFYHSHNWTMQLHIHAYRN 313 Query: 301 NNTPMFRRLGPDTGYDGINDLSLAEALSQLLDRAECGKGLPKTILYSLNPGDYPALLALM 360 NT M +LGPDTGYDG+NDLSL L +LL+RAE LPKTILY LNP DYPA+LALM Sbjct: 314 CNTQMLEKLGPDTGYDGMNDLSLTIPLQKLLNRAEETNQLPKTILYLLNPNDYPAILALM 373 Query: 361 GCYQKDTAGKLQLGSGWWYNDTRDGMRRQLTLLADNSLLGNFVGMLTDSRSFLSYTRHEY 420 GC+QK+ GKLQLGSGWWYNDTR GMR QLT AD S LGNFVGMLTDSRSFLSYTRHEY Sbjct: 374 GCFQKEQNGKLQLGSGWWYNDTRAGMRDQLTQFADGSALGNFVGMLTDSRSFLSYTRHEY 433 Query: 421 FRRVLCELLGELADRGEAPDDLALLGQLVEDIAYNNAAGYFGFEA 465 FRRVLCE LGE+ RGEAP+D LLG LV+ I+Y NA YFGF A Sbjct: 434 FRRVLCEFLGEMVMRGEAPEDEQLLGSLVQAISYTNAKNYFGFFA 478 >C1P818.1 C1P818_BACCO Glucuronate isomerase EC=5.3.1.12 Length = 470 Score = 597 bits (1538), Expect = e-168, Method: Compositional matrix adjust. Identities = 279/469 (59%), Positives = 348/469 (74%), Gaps = 7/469 (1%) Query: 1 MFLNDDFLLTSETARLLFHNHAKTMPIIDYHCHLDPKEIYEDKAFRNLTEAWLA----GD 56 MFLN DFLLT++ A+ LFHNHA+ MPIIDYHCHL+PKEIYE+K FR+L + W+ GD Sbjct: 1 MFLNQDFLLTTDFAKKLFHNHAEKMPIIDYHCHLNPKEIYENKNFRDLAQVWINEGHYGD 60 Query: 57 HYKWRLMRANGIPESHITGEASDYDKFLAWARTLPKAVGNPLYSWTHLELRRFFGINETL 116 HYKWRLMRANG+PE +ITG+A Y+KFL WA T+ K+VGNPLY WTHLELRRFF I+ L Sbjct: 61 HYKWRLMRANGVPEKYITGDADPYEKFLKWAETIEKSVGNPLYEWTHLELRRFFEIDTIL 120 Query: 117 NEASAPAIWEEVNRKLAEPAYTRRSLIRNSKVKTVCTTDDPADSLEYHRLLKESEQD--F 174 N +APAIWE+ N+ LA + R+LI+NS VK VCTTDDP D L+YH+LL+ESE + F Sbjct: 121 NRKTAPAIWEQANQLLATDDFKPRNLIKNSNVKVVCTTDDPVDDLQYHKLLQESETENGF 180 Query: 175 QVFPTFRPDKALNIDADGFTTWLTRLGEAAGVAVTTYAALVEALRSRVDFFHQNGCRLSD 234 +V P FRPDK LNI + ++ +L +GV++ ++ LV A+R+R+++FH+ G RLSD Sbjct: 181 KVLPAFRPDKVLNIQNKEYADYVHKLATVSGVSIQNFSDLVSAVRNRIEYFHERGGRLSD 240 Query: 235 HALDVLRYQAAGEASQLERIFTKRLEGAVLSPEEITVYRTELLSELIGMYHDKNWTMQLH 294 HALD Y A QL+ I K L LS EI Y T LL EL+ +YH+K W MQ H Sbjct: 241 HALDTFTYAEAA-PQQLDAIVEKALSQEALSLNEINQYHTALLIELMHIYHEKGWVMQYH 299 Query: 295 LHAFRNNNTPMFRRLGPDTGYDGINDLSLAEALSQLLDRAECGKGLPKTILYSLNPGDYP 354 +HA+RN N PMF +LGPDTGYD +ND +AE+ +L RAE +PKTILYSLNP D+ Sbjct: 300 IHAYRNLNGPMFEKLGPDTGYDALNDRCIAESYGKLFARAENEDIIPKTILYSLNPNDWL 359 Query: 355 ALLALMGCYQKDTAGKLQLGSGWWYNDTRDGMRRQLTLLADNSLLGNFVGMLTDSRSFLS 414 L+ +MGC+QKDT KLQLG WW+NDTR GMRRQL + A+ SLL NFVGMLTDSRSFLS Sbjct: 360 PLVTMMGCFQKDTVQKLQLGCAWWFNDTRSGMRRQLEMFAEESLLPNFVGMLTDSRSFLS 419 Query: 415 YTRHEYFRRVLCELLGELADRGEAPDDLALLGQLVEDIAYNNAAGYFGF 463 Y RHEYFRRVLCEL GE A+RG+ P+D +G+++EDIAY+NA YFGF Sbjct: 420 YPRHEYFRRVLCELFGEWAERGQIPEDEEQIGKIIEDIAYHNAYRYFGF 468 >Q2B7Q3.1 Q2B7Q3_9BACI Glucuronate isomerase EC=5.3.1.12 Length = 478 Score = 557 bits (1435), Expect = e-156, Method: Compositional matrix adjust. Identities = 266/475 (56%), Positives = 342/475 (72%), Gaps = 8/475 (1%) Query: 2 FLNDDFLLTSETARLLFHNHAKTMPIIDYHCHLDPKEIYEDKAFRNLTEAWLAGDHYKWR 61 F+ ++FLL +ETA L+H AK +PIIDYHCH+ PKEIYE+K F+N+TEAWL GDHYKWR Sbjct: 4 FMGENFLLKNETAAFLYHEEAKDLPIIDYHCHISPKEIYENKKFKNITEAWLYGDHYKWR 63 Query: 62 LMRANGIPESHITGEASDYDKFLAWARTLPKAVGNPLYSWTHLELRRFFGINETLNEASA 121 +MRANGI E +ITG+A DYDKFLAWART+P +GNPLY+WTHLEL+RFFGI + LNE SA Sbjct: 64 VMRANGINEKYITGDADDYDKFLAWARTVPMTIGNPLYNWTHLELQRFFGIYDILNEKSA 123 Query: 122 PAIWEEVNRKLAEPAYTRRSLIRNSKVKTVCTTDDPADSLEYHRLLKESEQDFQVF--PT 179 P IW +VN++LA + R +IR S V+ +CTTDDPADSLEYH+LL + E+DF V P Sbjct: 124 PDIWHKVNKQLATDDFRVREIIRKSNVRVICTTDDPADSLEYHKLLSK-EEDFPVLVVPG 182 Query: 180 FRPDKALNIDADGFTTWLTRLGEAAGVAVTTYAALVEALRSRVDFFHQNGCRLSDHALDV 239 FRPDK L I+ G+ W+ RL A+G+ V +Y++L+EAL SRV FFH G R+SDHALD Sbjct: 183 FRPDKGLEINRHGYKEWIERLEAASGITVDSYSSLLEALDSRVHFFHSLGGRVSDHALDQ 242 Query: 240 LRYQAAGEASQLERIFTKRLEGAVLSPEEITVYRTELLSELIGMYHDKNWTMQLHLHAFR 299 + Y+ A ++ +IF K+L G +S +E Y+T L L +Y W MQ H++A R Sbjct: 243 VVYEEAA-FEEVSQIFAKKLSGGTVSEKEEKQYKTYTLIHLGKLYASLGWAMQYHMNAHR 301 Query: 300 NNNTPMFRRLGPDTGYDGINDLSLAEALSQLLDRAECGKGLPKTILYSLNPGDYPALLAL 359 NNNT MF+ LGPDTGYD IND +A+ L LLD + GLPKTILYSLNPGD L ++ Sbjct: 302 NNNTKMFQTLGPDTGYDSINDDKIAKPLVSLLDSLDQAGGLPKTILYSLNPGDNHILASI 361 Query: 360 MGCYQKDT-AGKLQLGSGWWYNDTRDGMRRQLTLLADNSLLGNFVGMLTDSRSFLSYTRH 418 + +Q + GK+Q G+ WW+NDTRDGM Q+ LA+ L F+GMLTDSRSFLSYTRH Sbjct: 362 INSFQDGSIPGKIQFGTAWWFNDTRDGMLDQMKALANMGLFSRFIGMLTDSRSFLSYTRH 421 Query: 419 EYFRRVLCELLGELADRGEAPDDLALLGQLVEDIAYNNAAGYFGFEARSAAKLQH 473 EYFRRV+C L+GE + GE P+D LL ++++ I+Y NA YF F+ A+ QH Sbjct: 422 EYFRRVVCSLIGEWVENGEIPNDKELLSRIIKGISYYNAEEYFQFQ---EAEKQH 473 >Q65F21.1 UXAC_BACLD Uronate isomerase EC=5.3.1.12 Length = 473 Score = 553 bits (1424), Expect = e-155, Method: Compositional matrix adjust. Identities = 261/470 (55%), Positives = 336/470 (71%), Gaps = 2/470 (0%) Query: 2 FLNDDFLLTSETARLLFHNHAKTMPIIDYHCHLDPKEIYEDKAFRNLTEAWLAGDHYKWR 61 FLNDDFLLT+ET+++L+H +AK MPIIDYHCHL PKEIYE+K F+NLTE WL GDHYKWR Sbjct: 4 FLNDDFLLTNETSKVLYHQYAKGMPIIDYHCHLSPKEIYENKTFKNLTEVWLYGDHYKWR 63 Query: 62 LMRANGIPESHITGEASDYDKFLAWARTLPKAVGNPLYSWTHLELRRFFGINETLNEASA 121 MRANGI E ITG+ASD +KF AWART+P +GNPLY WTHLELRRFFGI++ L+E SA Sbjct: 64 AMRANGISEEFITGDASDEEKFSAWARTVPMTIGNPLYHWTHLELRRFFGIDDRLDEKSA 123 Query: 122 PAIWEEVNRKLAEPAYTRRSLIRNSKVKTVCTTDDPADSLEYHRLLKESEQDFQVFPTFR 181 P IWE VN +LA + R LI S V+TV TTDDP DSLEYH LK+ + + V P FR Sbjct: 124 PHIWERVNEQLAGGGFGARDLIEKSNVETVVTTDDPTDSLEYHVKLKDEDFNVSVLPGFR 183 Query: 182 PDKALNIDADGFTTWLTRLGEAAGVAVTTYAALVEALRSRVDFFHQNGCRLSDHALDVLR 241 PDKA+ I+ +GF W+ +L A+G+ + Y ++AL++R+DFFH+ G R+SDHA++ + Sbjct: 184 PDKAMEINQEGFAAWVRKLETASGMKIANYDDFLKALKNRIDFFHEAGGRISDHAINQMM 243 Query: 242 YQAAGEASQLERIFTKRLEGAVLSPEEITVYRTELLSELIGMYHDKNWTMQLHLHAFRNN 301 Y E S++ IF K + G SPEE +++ L L Y +K W MQLH++A RNN Sbjct: 244 YTETDE-SEVRPIFAKVMNGESASPEEECKFKSLTLHFLGTCYAEKGWAMQLHINALRNN 302 Query: 302 NTPMFRRLGPDTGYDGINDLSLAEALSQLLDRAECGKGLPKTILYSLNPGDYPALLALMG 361 ++ M+R+LGPDTGYD IND +A+ L LD + LPKTILYSLNP D + +L G Sbjct: 303 SSKMYRKLGPDTGYDAINDQDIAKPLCSFLDSLDRKDALPKTILYSLNPRDNVVISSLCG 362 Query: 362 CYQKD-TAGKLQLGSGWWYNDTRDGMRRQLTLLADNSLLGNFVGMLTDSRSFLSYTRHEY 420 +Q GK+Q G+ WW+NDT+DGM Q+ LA+ LL F+GMLTDSRSFLSYTRHEY Sbjct: 363 SFQDGRIPGKIQHGTAWWFNDTKDGMLEQMKSLANIGLLSRFIGMLTDSRSFLSYTRHEY 422 Query: 421 FRRVLCELLGELADRGEAPDDLALLGQLVEDIAYNNAAGYFGFEARSAAK 470 FRR+LC+++G + GEAPDD+ LLG++V+ I Y NA YF FE + K Sbjct: 423 FRRLLCDVIGTWVENGEAPDDIELLGRIVKGICYENAKHYFQFEVKDRLK 472 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.321 0.136 0.417 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,966,445,267 Number of extensions: 128739553 Number of successful extensions: 276869 Number of sequences better than 1.0e-05: 414 Number of HSP's gapped: 275397 Number of HSP's successfully gapped: 414 Length of query: 474 Length of database: 3,060,696,203 Length adjustment: 140 Effective length of query: 334 Effective length of database: 1,741,754,103 Effective search space: 581745870402 Effective search space used: 581745870402 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 133 (55.8 bits)