BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0345.0010.p (351 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KHK6.1 B3KHK6_9BACI Dihydroorotate oxidase EC=1.3.3.1 558 e-157 B1DMM1.1 B1DMM1_9BACL Dihydroorotate oxidase EC=1.3.3.1 487 e-136 Q1J132.1 PYRD_DEIGD Dihydroorotate dehydrogenase EC=1.3.3.1 372 e-101 C0Z506.1 C0Z506_BREBN Dihydroorotate dehydrogenase EC=1.3.3.1 352 3e-95 C1CX89.1 C1CX89_DEIDV Putative bifunctional protein: dihydroorot... 342 2e-92 >B3KHK6.1 B3KHK6_9BACI Dihydroorotate oxidase EC=1.3.3.1 Length = 370 Score = 558 bits (1438), Expect = e-157, Method: Compositional matrix adjust. Identities = 273/350 (78%), Positives = 305/350 (87%) Query: 1 MDPEKAHHLVIGGLNKSDLVPGGSAAMRLMYGVPETADLAVDLFGLHFPTPVGLAAGLDK 60 +DPEKAHHLV+GGL ++ V G A MR MYGV ET DLAVDLFGLHFPTPVGLAAGLDK Sbjct: 20 LDPEKAHHLVVGGLGRASGVVGADAVMRGMYGVNETPDLAVDLFGLHFPTPVGLAAGLDK 79 Query: 61 NAEAVGGFSSIGFGFMEVGTVTPKGQPGNDSPRLFRLLPDEALINRMGFNNKGAEAMAGR 120 NA AV GFSSIGFGFMEVGTVTPKGQPGN+ PRLFRL PDEALINRMGFNN+GAEAMA R Sbjct: 80 NAHAVKGFSSIGFGFMEVGTVTPKGQPGNEQPRLFRLPPDEALINRMGFNNEGAEAMAKR 139 Query: 121 LKAIKKRRIPVAVNIGRNKTTPNESAHEDYRQCIRTLYPYGDFFVVNISSPNTPDLRSLQ 180 L A+K+RRIPVAVNIG+NK TPNE A++DY CI+ L+PYGDFFVVNISSPNTPDLRSLQ Sbjct: 140 LSALKERRIPVAVNIGKNKATPNEKANDDYEACIQALFPYGDFFVVNISSPNTPDLRSLQ 199 Query: 181 HGSELSNLLAQVKEEMELQHQQSGAAKSLLVKIAPDVSDGELEYMVHTIAEAGMDGVIAT 240 HGSELS+LL V EM Q + G K++LVKIAPDVSD ELE+MV TI+ +G+ G+IAT Sbjct: 200 HGSELSSLLEAVMNEMSRQAKIHGGEKAVLVKIAPDVSDEELEFMVDTISASGVSGIIAT 259 Query: 241 NTTLSREGLQSDKAGETGGLSGKPLRDRSTEIISRIYRQTGGKLPIIGSGGIFTGQDAYD 300 NTTLSR+GL A ETGGLSGKPLR+RSTEI+SRIY+QTGG LPIIGSGGIFT +DAYD Sbjct: 260 NTTLSRDGLTHSNAKETGGLSGKPLRNRSTEIVSRIYKQTGGSLPIIGSGGIFTARDAYD 319 Query: 301 KIRAGASLVEIYTALIYEGPEVNRKVHAGLRKLLRRDGFSHILEAVGADH 350 KIRAGASLVEIYTALIYEGPEVNRK+H+GLR+LL R+GFSHI EAVGA+H Sbjct: 320 KIRAGASLVEIYTALIYEGPEVNRKLHSGLRELLAREGFSHISEAVGANH 369 >B1DMM1.1 B1DMM1_9BACL Dihydroorotate oxidase EC=1.3.3.1 Length = 427 Score = 487 bits (1254), Expect = e-136, Method: Compositional matrix adjust. Identities = 242/351 (68%), Positives = 285/351 (81%), Gaps = 1/351 (0%) Query: 1 MDPEKAHHLVIGGLNKSDLVPGGSAAMRLMYGVPETADLAVDLFGLHFPTPVGLAAGLDK 60 MDPEKAHHLVI GL+ + VPG + + MYGV ++ +LAVDLFG+HFP PVGLAAGLDK Sbjct: 76 MDPEKAHHLVIDGLHTAGRVPGMNNMLHAMYGVADSPELAVDLFGIHFPHPVGLAAGLDK 135 Query: 61 NAEAVGGFSSIGFGFMEVGTVTPKGQPGNDSPRLFRLLPDEALINRMGFNNKGAEAMAGR 120 N A GFSSIGFGF EVGTVTPKGQPGN+ PRLFRL DEALINRMGFNN+GAEAMA Sbjct: 136 NGVAADGFSSIGFGFAEVGTVTPKGQPGNELPRLFRLPSDEALINRMGFNNEGAEAMARE 195 Query: 121 LKAIKKRRIPVAVNIGRNKTTPNESAHEDYRQCIRTLYPYGDFFVVNISSPNTPDLRSLQ 180 L K RIP+AVN+G+NK TPNE AHEDYR CI+ LYPYGDFFVVNISSPNTPDLR+LQ Sbjct: 196 LSQRKINRIPIAVNVGKNKATPNERAHEDYRSCIQVLYPYGDFFVVNISSPNTPDLRALQ 255 Query: 181 HGSELSNLLAQVKEEMELQHQQSGA-AKSLLVKIAPDVSDGELEYMVHTIAEAGMDGVIA 239 HG EL LL +V EE+ LQ + G+ AK +LVKIAPD++D +LE V TI ++G+ G+IA Sbjct: 256 HGDELRTLLGEVLEEIGLQASKLGSKAKPVLVKIAPDMTDEQLELTVSTIKDSGVAGIIA 315 Query: 240 TNTTLSREGLQSDKAGETGGLSGKPLRDRSTEIISRIYRQTGGKLPIIGSGGIFTGQDAY 299 +NTT++REGL+ A ETGGLSG PLR+RSTE+I +YR T GKLPIIGSGGIFT DAY Sbjct: 316 SNTTITREGLKHPNAKETGGLSGAPLRERSTEVIRSVYRLTEGKLPIIGSGGIFTADDAY 375 Query: 300 DKIRAGASLVEIYTALIYEGPEVNRKVHAGLRKLLRRDGFSHILEAVGADH 350 DKIRAGASLVEIYTALIY+GP V R++ GL++ LR+DG+ ++ EAVGADH Sbjct: 376 DKIRAGASLVEIYTALIYKGPGVLRELTNGLKERLRKDGYRNVSEAVGADH 426 >Q1J132.1 PYRD_DEIGD Dihydroorotate dehydrogenase EC=1.3.3.1 Length = 361 Score = 372 bits (955), Expect = e-101, Method: Compositional matrix adjust. Identities = 190/349 (54%), Positives = 241/349 (69%), Gaps = 1/349 (0%) Query: 1 MDPEKAHHLVIGGLNKSDLVPGGSAAMRLMYGVPETADLAVDLFGLHFPTPVGLAAGLDK 60 +DPE AHHL + L + VP + +R + P L L+G F +P+GLAAGLDK Sbjct: 13 LDPEDAHHLTLRALGLASAVPAWPSLVRRLTA-PTDLRLTQTLWGRTFSSPLGLAAGLDK 71 Query: 61 NAEAVGGFSSIGFGFMEVGTVTPKGQPGNDSPRLFRLLPDEALINRMGFNNKGAEAMAGR 120 N EAV F ++GFGF+EVGTVTP+ QPGN PRLFRL DEALINRMGFNN GAEA+ G+ Sbjct: 72 NGEAVPAFGALGFGFVEVGTVTPRAQPGNARPRLFRLPSDEALINRMGFNNAGAEALQGQ 131 Query: 121 LKAIKKRRIPVAVNIGRNKTTPNESAHEDYRQCIRTLYPYGDFFVVNISSPNTPDLRSLQ 180 L A R +PV VNIG+NK TPNE A +DYR+ +R L D FVVN+SSPNTP LR+LQ Sbjct: 132 LAAHFARPVPVWVNIGKNKVTPNEEAVQDYREAVRVLQAVADAFVVNVSSPNTPGLRALQ 191 Query: 181 HGSELSNLLAQVKEEMELQHQQSGAAKSLLVKIAPDVSDGELEYMVHTIAEAGMDGVIAT 240 +L+ L+ V +E+E ++ + +LVK+APD+ + E V + EAG DG+I Sbjct: 192 AAGDLAALVRAVLDEVEAGRVRTLSRPPVLVKLAPDLHPADFEASVGAVLEAGADGLIIG 251 Query: 241 NTTLSREGLQSDKAGETGGLSGKPLRDRSTEIISRIYRQTGGKLPIIGSGGIFTGQDAYD 300 NTTL REGL + GETGGLSG+PL RSTE++ YR T G++PI+G GGIFT +DAY Sbjct: 252 NTTLRREGLTHPRRGETGGLSGRPLTARSTELVRAAYRLTRGRMPIVGVGGIFTAEDAYA 311 Query: 301 KIRAGASLVEIYTALIYEGPEVNRKVHAGLRKLLRRDGFSHILEAVGAD 349 KIRAGA LVE+YTALIYEGP + +++ L +LL RDG H+ EAVG D Sbjct: 312 KIRAGARLVEVYTALIYEGPGLPARLNRDLARLLARDGVRHLTEAVGVD 360 >C0Z506.1 C0Z506_BREBN Dihydroorotate dehydrogenase EC=1.3.3.1 Length = 363 Score = 352 bits (903), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 173/349 (49%), Positives = 235/349 (67%), Gaps = 2/349 (0%) Query: 2 DPEKAHHLVIGGLNKSDLVPGGSAAMRLMYGVPETADLAVDLFGLHFPTPVGLAAGLDKN 61 D E+ H IG L + G + ++++Y V + L L+G+ FP PVGLAAG DKN Sbjct: 13 DAEEIHEKTIGALRLVEDSAPGKSILKMIYQVKDQR-LENKLWGMTFPNPVGLAAGFDKN 71 Query: 62 AEAVGGFSSIGFGFMEVGTVTPKGQPGNDSPRLFRLLPDEALINRMGFNNKGAEAMAGRL 121 AE ++GFGF+E+GT+TP+GQPGN PRLFRL +A+INRMGFNN GA + L Sbjct: 72 AEVYHALGALGFGFVEIGTLTPQGQPGNPKPRLFRLPEHQAVINRMGFNNHGAYLASQHL 131 Query: 122 KAIKKRRIPVAVNIGRNKTTPNESAHEDYRQCIRTLYPYGDFFVVNISSPNTPDLRSLQH 181 +P+ +NIG+NK TPNE A DY +C+ LY YG +FV+NISSPNTP+LR LQ Sbjct: 132 VDYAYSDVPIGINIGKNKVTPNEEAAVDYSKCMDMLYAYGHYFVINISSPNTPNLRDLQE 191 Query: 182 GSELSNLLAQVKEEMELQHQQSGAAKSLLVKIAPDVSDGELEYMVHTIAEAGMDGVIATN 241 L +L+ VKE+ +S K +L+K+APD+SD + +VH E G+ G+IATN Sbjct: 192 TESLRHLVRAVKEKATEMEGRSIKKKPILLKVAPDMSDEHMRDVVHAAVEEGISGIIATN 251 Query: 242 TTLSREGLQSDK-AGETGGLSGKPLRDRSTEIISRIYRQTGGKLPIIGSGGIFTGQDAYD 300 TTLSRE + + A E GGLSG+PL +RST + IY++ G K+PIIG GGI+ G+DAY Sbjct: 252 TTLSREAVSGHRFAEEAGGLSGRPLTERSTAWVKEIYQEVGDKVPIIGVGGIYNGEDAYA 311 Query: 301 KIRAGASLVEIYTALIYEGPEVNRKVHAGLRKLLRRDGFSHILEAVGAD 349 KIRAGASLV++YT +IY+GP + ++++ L KL++RDGF HI E +G D Sbjct: 312 KIRAGASLVQVYTGMIYQGPGIAKQINKKLLKLMQRDGFKHISEVIGVD 360 >C1CX89.1 C1CX89_DEIDV Putative bifunctional protein: dihydroorotate oxidase (Dihydroorotate dehydrogenase)/dihydropyrimidine dehydrogenase (NADP(+)) Length = 360 Score = 342 bits (878), Expect = 2e-92, Method: Compositional matrix adjust. Identities = 187/350 (53%), Positives = 238/350 (68%), Gaps = 4/350 (1%) Query: 1 MDPEKAHHLVIGGLNKSDLVPGGSAAMRLMYGVPETADLAVDLFGLHFPTPVGLAAGLDK 60 +D E AHHL + L +PG AA R + P + L L+G + +PVGLAAGLDK Sbjct: 13 LDAEDAHHLTVNALALMSRLPGWPAAARRL-SAPADSRLMQTLWGHTYASPVGLAAGLDK 71 Query: 61 NAEAVGGFSSIGFGFMEVGTVTPKGQPGNDSPRLFRLLPDEALINRMGFNNKGAEAMAGR 120 N AV FS++GFGF+EVGTVTP+ QPGND PRLFRL PDEALINRMGFNN GA A+ G+ Sbjct: 72 NGVAVPAFSALGFGFVEVGTVTPQPQPGNDRPRLFRLPPDEALINRMGFNNAGAAALRGQ 131 Query: 121 LKAIKKRRIPVAVNIGRNKTTPNESAHEDYRQCIRTLYPYGDFFVVNISSPNTPDLRSLQ 180 L + +R +PV VNIG+NK T E A +DY C++ LY D FVVN+SSPNTP LR+LQ Sbjct: 132 LSRLGRRTVPVWVNIGKNKLT--EEAAQDYVACVQELYDVADAFVVNVSSPNTPGLRALQ 189 Query: 181 HGSELSNLLAQVKEEMELQHQQSGA-AKSLLVKIAPDVSDGELEYMVHTIAEAGMDGVIA 239 +EL LL V E E Q ++ A +LVK+APD+ + E V AG+ G+I Sbjct: 190 ASAELEALLRAVLNETEAQRLRTARRAPPVLVKLAPDLHPADFEASVQGALNAGVQGLIV 249 Query: 240 TNTTLSREGLQSDKAGETGGLSGKPLRDRSTEIISRIYRQTGGKLPIIGSGGIFTGQDAY 299 +NTTLSR+GL + GGLSG+PL RST ++ YR T G +P++G GGIF+ DAY Sbjct: 250 SNTTLSRDGLTHAHREQAGGLSGRPLTGRSTALVQDAYRLTRGAVPVVGVGGIFSADDAY 309 Query: 300 DKIRAGASLVEIYTALIYEGPEVNRKVHAGLRKLLRRDGFSHILEAVGAD 349 KIRAGASLVE+Y++LIYEGP + ++H GL +LL RDG SH+ +AVGAD Sbjct: 310 AKIRAGASLVEVYSSLIYEGPGLPARIHRGLGQLLERDGISHVRDAVGAD 359 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.316 0.136 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,196,705,119 Number of extensions: 97186580 Number of successful extensions: 286698 Number of sequences better than 1.0e-05: 1754 Number of HSP's gapped: 283736 Number of HSP's successfully gapped: 1789 Length of query: 351 Length of database: 3,060,696,203 Length adjustment: 136 Effective length of query: 215 Effective length of database: 1,779,438,163 Effective search space: 382579205045 Effective search space used: 382579205045 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 132 (55.5 bits)