BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0290.0014.p (581 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B1DHH9.1 B1DHH9_9BACL Histidine kinase internal region 347 2e-93 B3KD30.1 B3KD30_9BACI Histidine kinase internal region 338 7e-91 B3K539.1 B3K539_9BACI Histidine kinase internal region 327 2e-87 B1DAG5.1 B1DAG5_9BACL Histidine kinase internal region 325 1e-86 B1D8T7.1 B1D8T7_9BACL Signal transduction histidine kinase, LytS 296 3e-78 >B1DHH9.1 B1DHH9_9BACL Histidine kinase internal region Length = 570 Score = 347 bits (890), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 199/575 (34%), Positives = 320/575 (55%), Gaps = 12/575 (2%) Query: 1 MAWRPNLFIKMVAILLSLISVTLLFYGLSYRKDIGVITSQIKTTDLNHLEFLTQQMDNNI 60 M R N+F K+ ++L L+ L Y S R+ + VI ++I++ N L Q+++NI Sbjct: 1 MLLRFNVFTKISLLVLLLLIPVLSLYTYSNRESVRVIENEIQSGTTNRLSSFAAQVESNI 60 Query: 61 NQLAGSMYALQRDPTVRDYEQIRQLGHLIDPAQTIMTVLEKLSLQTSSSTWENRIVLYKP 120 QL+ ++ +D ++++Y++ + + + +LEK++L ++S W + I L+ P Sbjct: 61 YQLSLYGVSIGQDSSIQEYQRPDFREQPYERVKLSVAILEKMNLYNAASKWHSTITLFFP 120 Query: 121 HSGETLGXXXXXXXXXX--ILGKPLPAGWEYISEDKGSAEAGFRLLLSDPIESRNDPRQA 178 +G+ L KP WEY + F ++P + ++PR A Sbjct: 121 RTGDALSTEYYNTITYREDAFTKPFLKSWEYTGD-------SFVWYATEPTTAMSNPRSA 173 Query: 179 GLLMSMYFPVSNIERMFDAYQSQNKGDTFLFHPAFGVILSRNTDRELAERIVATLTSST- 237 L+ + FP++++ M D + N GD FLF+P G I + + + + + L SS Sbjct: 174 RLITKISFPINHVTTMLDENKVNNSGDPFLFNPEQGSIRNHSANSAKIDLLSEKLKSSKL 233 Query: 238 GQGSSDIFSLKEGSFLVSSVPSSAINWQVVHYSPLKQILQPIRSSRYSFLTGXXXXXXXX 297 G+ L + VS + S ++ W V Y P++QIL PI +SR F T Sbjct: 234 GERGGFRTKLDNTEYYVSYIKSDSLKWYYVDYVPMQQILSPITNSRNLFYTSIAVLLVMS 293 Query: 298 XXXXXXXYRQVQRPVSLLLRSLNRMKEGRWSTRI-HTRTNPEFTMLNEEFNEMAEKIQSL 356 YR VQ P+ L+R R+ G +S R+ H+ TN EF++L FN MA++IQ L Sbjct: 294 IAVIFVIYRSVQVPLLQLVRGTKRLSSGDFSVRLSHSGTN-EFSLLLGRFNIMAQRIQEL 352 Query: 357 IEQVYLEQLRAKDAHLKQLQSQINPHFLYNCLFFIKSKAVVGDTGSVEAMALNLGEYYRY 416 IE VY E+LR ++A LK LQSQINPHFLYNCLF+IK+ A + + +V AMALNLG+Y+RY Sbjct: 353 IENVYEEKLRRREATLKHLQSQINPHFLYNCLFYIKNMARMKNEKAVVAMALNLGDYFRY 412 Query: 417 ITKADHSLTTLQDELKLLENYLEIQNLRKQRICYEMDIADDLLGLHIPRLLIQPLVENSI 476 IT++++ + T+++EL ++ NYLEIQ+LR +R+ + +++ D+L+ I RL +QP+VEN+I Sbjct: 413 ITRSENDVATIREELSMVTNYLEIQSLRLERMRFAIEVPDELMNKTISRLTLQPIVENAI 472 Query: 477 IHGIEKKIGQGFIRITASXXXXXXXXXXXDNGAGMTSEAIASLHARMSEPTREDGGCGLW 536 +HG+E + G IRI D+G GMT E I L +++P ++ GCG W Sbjct: 473 VHGLEPQAENGEIRIRGYAEDGMYRLVVEDSGIGMTDEEIQKLQLSLTKPLDDNMGCGTW 532 Query: 537 NIQQRLKTHYGDSSGLLIAPSSEGGLQITLRMEKK 571 N+ QRL +G+ +GL S GG++ T+ K Sbjct: 533 NVHQRLIYLFGEGAGLSYTRSDLGGIKTTITWSDK 567 >B3KD30.1 B3KD30_9BACI Histidine kinase internal region Length = 578 Score = 338 bits (868), Expect = 7e-91, Method: Compositional matrix adjust. Identities = 196/568 (34%), Positives = 300/568 (52%), Gaps = 12/568 (2%) Query: 4 RPNLFIKMVAILLSLISVTLLFYGLSYRKDIGVITSQIKTTDLNHLEFLTQQMDNNINQL 63 R + F K+ +L L+ +L Y S++ I V+ S ++ N L F QMD I+QL Sbjct: 5 RTSTFAKLTTLLAVLVIPIILLYAYSHQVSINVVRSAVEEGQRNRLTFFMSQMDTMIDQL 64 Query: 64 AGSMYALQRDPTVRDYEQIRQLGHLIDPAQTIMTVLEKLSLQTSSSTWENRIVLYKPHSG 123 D ++ Y R ++ + + + L++Q ++S+W+++I++Y Sbjct: 65 TKYSVIASNDDGIKSYLAERSGSTPMERIDSQQRITDMLNMQIATSSWDSQILMYLTQYR 124 Query: 124 ETLGXXXXXXXXXXILGKPLPAGWEYISEDKGSAEAGFRLLLSDPIESRNDPRQAGLLMS 183 E L L W Y + +G +A F + R L++ Sbjct: 125 ELLTTDLSARYDAEYLAHAHKQNWTYHRDSRG--QAFFSWM-------RTSASSQDLIVE 175 Query: 184 MYFPVSNIERMFDAYQSQNKGDTFLFHPAFGVILSRNTDRELAERIVA-TLTS-STGQGS 241 + F N+ M + + + FL+ P G +++ +T E R+ A TL G+ Sbjct: 176 VRFTDQNLVNMLNRLKQDGDSEPFLYAPD-GTVIANSTSVEETIRMAAGTLNELQLGEEG 234 Query: 242 SDIFSLKEGSFLVSSVPSSAINWQVVHYSPLKQILQPIRSSRYSFLTGXXXXXXXXXXXX 301 S I +G ++++ V SS++ W +V + L + PI S F Sbjct: 235 SRIVQSGQGKYVMNYVLSSSLGWYLVDFVRLDSVYSPITLSSVLFYISVSLLLVLVLLLT 294 Query: 302 XXXYRQVQRPVSLLLRSLNRMKEGRWSTRIHTRTNPEFTMLNEEFNEMAEKIQSLIEQVY 361 YR VQRP+S LL ++ R+++G++ TR+ EF L FN MAE+I+ LIE+VY Sbjct: 295 LLLYRNVQRPISRLLHAVRRIRDGQYMTRLKDVPKNEFMYLFHSFNNMAEQIEELIERVY 354 Query: 362 LEQLRAKDAHLKQLQSQINPHFLYNCLFFIKSKAVVGDTGSVEAMALNLGEYYRYITKAD 421 E LR+K+A LKQLQSQINPHFLYNCLF+IK+ A +GD +V AMALNLGEYYRY T+ + Sbjct: 355 KESLRSKEATLKQLQSQINPHFLYNCLFYIKNMANLGDKEAVVAMALNLGEYYRYTTRLE 414 Query: 422 HSLTTLQDELKLLENYLEIQNLRKQRICYEMDIADDLLGLHIPRLLIQPLVENSIIHGIE 481 L++E+KL++NYL IQ LR QR+ +E+++ D ++ L IPRLL+QP+VEN++IHG+E Sbjct: 415 KPTAPLEEEVKLVDNYLTIQMLRLQRLTFEIEVPDSMMQLEIPRLLLQPIVENAVIHGVE 474 Query: 482 KKIGQGFIRITASXXXXXXXXXXXDNGAGMTSEAIASLHARMSEPTREDGGCGLWNIQQR 541 ++ I I+ +NG GM I L ++ EP E GG GLWNI QR Sbjct: 475 DQLDFAMIHISGEIEGSRCRIRIDNNGQGMDVGIIDKLKRQVEEPLNESGGFGLWNIHQR 534 Query: 542 LKTHYGDSSGLLIAPSSEGGLQITLRME 569 L T YG +GL + S GGL++ + E Sbjct: 535 LVTRYGKHAGLAFSESPSGGLRVEICWE 562 >B3K539.1 B3K539_9BACI Histidine kinase internal region Length = 596 Score = 327 bits (839), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 186/566 (32%), Positives = 296/566 (52%), Gaps = 6/566 (1%) Query: 6 NLFIKMVA-ILLSLISVTLLFYGLSYRKDIGVITSQIKTTDLNHLEFLTQQMDNNINQLA 64 NLF K+V I L LI + L++ S + V++ ++ ++ N L F Q++ NI+ LA Sbjct: 5 NLFRKIVLFIFLMLIPIVGLYF-YSNQTTTNVLSKELSQSNTNQLVFFQNQVNTNIDILA 63 Query: 65 GSMYALQRDPTVRDYEQIR-QLGHL-IDPAQTIMTVLEKLSLQTSSSTWENRIVLYKPHS 122 L DP + + I Q +L +D + + KLS+Q SSS W + + +Y P Sbjct: 64 SWPNLLLHDPDISSFRDIYLQDKYLNLDAINLVKQIQTKLSIQESSSNWRSHLAIYSPSL 123 Query: 123 GETLGXXXXXXXXXXILGKPLPAGWEYISEDKGSAEAGFRLLLS-DPIESRNDPRQAGLL 181 G + L + + GW+ +GS + S P +++ ++ + Sbjct: 124 GRVVTESDAGFYSPEELAEDVKPGWQVTPYYEGSDRRFLFVWYSVAPYSTQHRTGKSNTV 183 Query: 182 MSMYFPVSNIERMFDAYQSQNKGDTFLFHPAFGVILSRNTDRELAERIVATLTSSTGQGS 241 + + F +NI+ M D ++S + D F + P GVI +R D+EL ++A L + Sbjct: 184 IKVEFDSTNIQDMLDRFKSDGRSDPFYYKPDSGVIYNRTADQELINHMMAELDREPLEDV 243 Query: 242 SD-IFSLKEGSFLVSSVPSSAINWQVVHYSPLKQILQPIRSSRYSFLTGXXXXXXXXXXX 300 + + + ++ VS V S W ++ Y PL I++PI +S F Sbjct: 244 ENRVKEVGGKTYSVSIVLSETTGWYLIDYIPLSDIMKPIHTSNRLFYISIAALLLMSCLA 303 Query: 301 XXXXYRQVQRPVSLLLRSLNRMKEGRWSTRIHTRTNPEFTMLNEEFNEMAEKIQSLIEQV 360 Y QVQ P+ L+ R++ G + R+ EF+ L FN M E+IQ L E V Sbjct: 304 AYLLYSQVQVPIKQLVYVFRRLQAGDYGVRMKVAGRNEFSFLATRFNSMVEQIQELFEHV 363 Query: 361 YLEQLRAKDAHLKQLQSQINPHFLYNCLFFIKSKAVVGDTGSVEAMALNLGEYYRYITKA 420 Y+E++ ++A LKQLQSQINPHF YNC FI S A + +V AM+ +L Y+RY T+ Sbjct: 364 YMEKIHVREAKLKQLQSQINPHFFYNCFSFITSMAKLRKYEAVVAMSHSLSRYFRYTTRQ 423 Query: 421 DHSLTTLQDELKLLENYLEIQNLRKQRICYEMDIADDLLGLHIPRLLIQPLVENSIIHGI 480 + L L DE++ + +YLEIQ +R +R+ Y + + ++ G+ IP L+IQPLVEN+++HGI Sbjct: 424 ERELVPLSDEVEFVTHYLEIQQMRMRRLQYHLVLTEEAEGMEIPPLVIQPLVENAVLHGI 483 Query: 481 EKKIGQGFIRITASXXXXXXXXXXXDNGAGMTSEAIASLHARMSEPTREDGGCGLWNIQQ 540 E G G IR+T DNG GM E +A L AR++ P ++ GCG+WN+ Q Sbjct: 484 EPHSGDGEIRVTFRIVNGLACIQVDDNGIGMNGEKLAELEARLNRPMDQEMGCGVWNVHQ 543 Query: 541 RLKTHYGDSSGLLIAPSSEGGLQITL 566 R++ YG+ +GL A S +GG++ L Sbjct: 544 RMRLRYGEEAGLRFAASPQGGVRAVL 569 >B1DAG5.1 B1DAG5_9BACL Histidine kinase internal region Length = 582 Score = 325 bits (832), Expect = 1e-86, Method: Compositional matrix adjust. Identities = 196/575 (34%), Positives = 303/575 (52%), Gaps = 10/575 (1%) Query: 6 NLFIKMVA-ILLSLISVTLLFYGLSYRKDI--GVITSQIKTTDLNHLEFLTQQMDNNINQ 62 +LF+K + I+L I + +LF +Y ++ GVI +I+ +++ L FL+ Q+++ INQ Sbjct: 11 SLFVKYLGLIILLFIPIGILF---AYSNNVATGVIGKEIRNSNIKQLSFLSSQIESRINQ 67 Query: 63 LAGSMYALQRDPTVRDYEQIRQLGHLIDPAQTIMTVLEKLSLQTSS-STWENRIVLYKPH 121 ++ +DP V+ Y + D QT VLEK++LQ+ + W +Y Sbjct: 68 TMDFVFTFSKDPNVQKYNGLNIWDDNYDWMQTRYMVLEKMALQSGVVNIWPVEFTVYSQL 127 Query: 122 SGETLGXXXXXXXXXX-ILGKPLPAGWEYISEDKGSAEAGFRLLLSDPIESRNDPRQAGL 180 E L L + + W Y G+ FR +D + + + L Sbjct: 128 HKEALSNSSTSVAYDEDYLKRNISKNWTYSEGATGTEGMAFRWYYADSL-GQQKLTGSNL 186 Query: 181 LMSMYFPVSNIERMFDAYQSQNKGDTFLFHPAFGVILSRNTDRELAERIVATLTSSTGQG 240 ++ F SNI+ M D Y+ +GD + P IL+R+ ELAE + L + Sbjct: 187 VVGASFGSSNIQNMLDTYKEGGQGDPLFYAPGQKPILNRSASPELAEELTRYLDGQKLED 246 Query: 241 S-SDIFSLKEGSFLVSSVPSSAINWQVVHYSPLKQILQPIRSSRYSFLTGXXXXXXXXXX 299 S L S+LVS V S + W +V PL QIL PI SSR F Sbjct: 247 SMQKTIKLNGQSYLVSLVKSPQLEWYLVDPVPLDQILGPISSSRNLFYLAMALLLVIGAF 306 Query: 300 XXXXXYRQVQRPVSLLLRSLNRMKEGRWSTRIHTRTNPEFTMLNEEFNEMAEKIQSLIEQ 359 YR VQRP+ L+R L +++ G +S RIH + N EFT L FN+M+ +I++LI+ Sbjct: 307 FSIVLYRDVQRPILKLIRGLKKVQLGDFSARIHAKANSEFTFLFYRFNDMSAQIETLIDN 366 Query: 360 VYLEQLRAKDAHLKQLQSQINPHFLYNCLFFIKSKAVVGDTGSVEAMALNLGEYYRYITK 419 V E+L A++A +KQLQ+QINPHFLYNCL ++ + A + D +V M +L YYRYIT+ Sbjct: 367 VLKERLIAQEATMKQLQAQINPHFLYNCLGYMINMAQMKDEEAVVKMGYSLSSYYRYITR 426 Query: 420 ADHSLTTLQDELKLLENYLEIQNLRKQRICYEMDIADDLLGLHIPRLLIQPLVENSIIHG 479 + +++LQDE++L+ NYL+IQ +R RI Y +DI +++ G +PRL++QPLVEN++IHG Sbjct: 427 MEKPVSSLQDEIQLIVNYLDIQKMRNGRIHYSIDIPEEMRGQQVPRLMLQPLVENAVIHG 486 Query: 480 IEKKIGQGFIRITASXXXXXXXXXXXDNGAGMTSEAIASLHARMSEPTREDGGCGLWNIQ 539 + K G IRI D+G G+ E + ++ +M P ++D G GLWN Sbjct: 487 VSKSYSSGEIRIAGQIEGGFWRIFVDDDGPGLDGEKLELMNQKMRGPMQDDMGYGLWNTN 546 Query: 540 QRLKTHYGDSSGLLIAPSSEGGLQITLRMEKKEES 574 QR+ +G S L + S GG + + E +E+ Sbjct: 547 QRIIHCFGPRSSLSFSSSELGGFRTEIVWEIPKEA 581 >B1D8T7.1 B1D8T7_9BACL Signal transduction histidine kinase, LytS Length = 575 Score = 296 bits (759), Expect = 3e-78, Method: Compositional matrix adjust. Identities = 178/583 (30%), Positives = 299/583 (51%), Gaps = 15/583 (2%) Query: 1 MAWRPNLFIKMVAILLSLISVTLLFYGLSYRKDIGVITSQIKTTDLNHLEFLTQQMDNNI 60 M+ R N F K+V I++ L+ + Y S + + V+ ++++ + L + Q D Sbjct: 1 MSLRLNTFTKIVGIIVLLLIPIIALYWFSNKTSMDVVMNEVEISMHKDLSYFAAQTDETA 60 Query: 61 NQLAGSMYALQRDPTVRDYEQIRQLGHLIDPAQTIMTVLEKLSLQTSSSTWENRIVLYKP 120 QLA S + D VR E + ++ L + + + +KL L +SS W+ I +Y P Sbjct: 61 EQLAKSGLMITEDINVRTLEFL-EIATLYEQTDQKIRIADKLRLINASSDWDTTISIYAP 119 Query: 121 HSGETLGXXXXXXXXXXILGKPLPAGWEYISEDKGSAEAGFRLL--LSDPIESRNDPRQA 178 + + ++ K W+Y + R + LS+P +S + A Sbjct: 120 ATNTFVSTDFHLEYDKDLVTKNYSKVWKYTENVAPYYQNNPRFVRFLSEPYDSSSS--NA 177 Query: 179 GLLMSMYFPVSNIERMFDAYQSQNKGDTFLFHPAFGVILSRNTDRELAERIVATLT-SST 237 G+++ + F + + + +++ +KGD F P ++ +D EL ++++A + Sbjct: 178 GVIVEVSFSADELVKALERFKAGSKGDVFFSSPDQRILAVNGSDAELQKKLLAKVNLEKL 237 Query: 238 GQGSSDIFSLKEGSFLVSSVPSSAINWQVVHYSPLKQILQPIRSSRYSFLTGXXXXXXXX 297 + L + V+SV + W + Y P+ +++PI ++ F Sbjct: 238 SESQYTRIKLDGIEYTVNSVYMPELGWYLFDYLPIDDVVRPITANSNLFYICIVFLLIGS 297 Query: 298 XXXXXXXYRQVQRPVSLLLRSLNRMKEGRWSTRIHTRTNPEFTMLNEEFNEMAEKIQSLI 357 Y VQ P+ L+R + ++K+G + N EF L FN+MA +I+ LI Sbjct: 298 TIAAYVLYTNVQVPIRELIRGVKKLKKGEYPKLKVFHPNNEFHFLLVSFNDMASQIEQLI 357 Query: 358 EQVYLEQLRAKDAHLKQLQSQINPHFLYNCLFFIKSKAVVGDTGSVEAMALNLGEYYRYI 417 + VYLEQ+R++DA+LKQLQSQINPHFLYNC I+S +G+ SV +AL+L YYRY Sbjct: 358 QNVYLEQIRSRDANLKQLQSQINPHFLYNCFSLIRSLTRLGEKESVMELALHLSRYYRYT 417 Query: 418 TKADHSLTTLQDELKLLENYLEIQNLRKQRICYEMDIADDLLGLHIPRLLIQPLVENSII 477 T+++ L L++E++L+++YL IQ + Q + Y + I + + L IPRL++QP+VEN+++ Sbjct: 418 TRSERQLAYLREEIELVKSYLAIQAMNVQDMTYVITIPEAMEELEIPRLILQPIVENAVL 477 Query: 478 HGIEKKIGQGFIRITASXXXXXXXXXXXDNGAGMTSEAIASLHARMSEPTREDGGCGLWN 537 HG+E IG G ++IT S DNG G+T E +A L +MS P ED GC LWN Sbjct: 478 HGLE-PIGGGEVQITGSQNDRYNVITVTDNGVGVTEEQLAQLKLQMSMPPTEDKGCALWN 536 Query: 538 IQQRLKTHYGDSSGLLIAPSSEGGLQITLRMEKKEESYAPNSA 580 +QR+ YG +G+ + +GGL + L Y PN + Sbjct: 537 TRQRMTLQYGQEAGVRLIRGDDGGLTVEL--------YWPNDS 571 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.318 0.134 0.384 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,058,998,497 Number of extensions: 116038847 Number of successful extensions: 319959 Number of sequences better than 1.0e-05: 1890 Number of HSP's gapped: 316522 Number of HSP's successfully gapped: 1890 Length of query: 581 Length of database: 3,060,696,203 Length adjustment: 141 Effective length of query: 440 Effective length of database: 1,732,333,088 Effective search space: 762226558720 Effective search space used: 762226558720 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 134 (56.2 bits)