BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0264.0017.p (426 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KGB6.1 B3KGB6_9BACI Dihydroorotase EC=3.5.2.3 666 0.0 B1DKL0.1 B1DKL0_9BACL Dihydroorotase EC=3.5.2.3 617 e-175 Q9K9V7.1 PYRC_BACHD Dihydroorotase EC=3.5.2.3 534 e-150 Q5L0U5.1 PYRC_GEOKA Dihydroorotase EC=3.5.2.3 509 e-142 P46538.1 PYRC_BACCL Dihydroorotase EC=3.5.2.3 509 e-142 >B3KGB6.1 B3KGB6_9BACI Dihydroorotase EC=3.5.2.3 Length = 433 Score = 666 bits (1718), Expect = 0.0, Method: Compositional matrix adjust. Identities = 325/428 (75%), Positives = 363/428 (84%), Gaps = 5/428 (1%) Query: 2 IIKNASVLNGEGVLERKHIVVQDGIISAIKDGSEAVDEAG---EIVEAEGKLLIPGLIDM 58 +IKNA V+N +G LE KHIV+ DG+I ++ A+ E G +I++AEGKL+ PG IDM Sbjct: 5 VIKNAKVINEQGQLEDKHIVIADGLIQSVASDIAALPEPGDHVQIIDAEGKLVTPGFIDM 64 Query: 59 HVHLREPGFEHKETIETGARSAAKGGFTTIACMPNTRPVTDSPEIVQFVKDKAAEAGLVK 118 HVHLREPG+EHKETIE+G+RSA KGGFTTIACMPNTRPVTD+PE V+ V DKA+EA L K Sbjct: 65 HVHLREPGYEHKETIESGSRSAVKGGFTTIACMPNTRPVTDTPETVKLVLDKASEANLAK 124 Query: 119 VLPYAAITKNELGRELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAMKIAAGLDMPVIAH 178 VLPYAAITKNELGRELTDF ALK AGAIGFTDDGVGVQ+AQMMKDAM A L MPVIAH Sbjct: 125 VLPYAAITKNELGRELTDFEALKAAGAIGFTDDGVGVQNAQMMKDAMNKAKALGMPVIAH 184 Query: 179 CEDNSLVEGCAVAEGTFAAKHGLRGIPNESEAIHVGRDILLAEATGVHYHVCHVSTEQSV 238 CED+SLV+G V EG FA +HGL+GIPNESEAIHVGRDILL EATGVHYHVCHVSTEQSV Sbjct: 185 CEDDSLVKGACVTEGKFAQQHGLKGIPNESEAIHVGRDILLTEATGVHYHVCHVSTEQSV 244 Query: 239 RLIRQAKEIGIKVTAEVCPHHLLLSEEDIPGLDAXXXXKTPPPLRSRRDVEACIAGLLDG 298 RLIRQAK IGI VTAEVCPHHL+LS+EDIPGLDA K PPLR+ RDVEACI GLLDG Sbjct: 245 RLIRQAKAIGISVTAEVCPHHLVLSDEDIPGLDA--NWKMNPPLRTPRDVEACIEGLLDG 302 Query: 299 TIDIIVTDHAPHSEEEKAKGMQLAPFGIVGFETAFPLLYTAFVATGKWDLSLLVQRMTAD 358 T+D+IVTDHAPHS EEKAKGM+LAPFGIVGFETAFPLLYT FVATGKWDL+LLV+RMT+D Sbjct: 303 TLDMIVTDHAPHSAEEKAKGMELAPFGIVGFETAFPLLYTKFVATGKWDLALLVKRMTSD 362 Query: 359 PARVFRLNTGSLTVGLPADLTLIDLTEEKEVDPASFASKGRNTPFGGWKLKGWPVKTWVN 418 PARVF L TG L G ADLT+IDL EKEV+P FA+KGRNTPF GWKLKGWPV TWV+ Sbjct: 363 PARVFGLATGVLEAGKAADLTMIDLEAEKEVNPEEFATKGRNTPFTGWKLKGWPVMTWVD 422 Query: 419 GTAVWTEE 426 G W+E+ Sbjct: 423 GEVKWSEQ 430 >B1DKL0.1 B1DKL0_9BACL Dihydroorotase EC=3.5.2.3 Length = 430 Score = 617 bits (1592), Expect = e-175, Method: Compositional matrix adjust. Identities = 301/427 (70%), Positives = 350/427 (81%), Gaps = 4/427 (0%) Query: 1 VIIKNASVLN-GEGVLERKHIVVQDGIISAIKDGSEAVDE-AGEIVEAEGKLLIPGLIDM 58 V I N SV + G L++KHI ++ I+ I DGS A D + E+++A GKL+ G IDM Sbjct: 3 VWIINGSVWDKASGSLQKKHIRLEGEQIAEIVDGSAAPDTGSAEVIDAAGKLVSAGFIDM 62 Query: 59 HVHLREPGFEHKETIETGARSAAKGGFTTIACMPNTRPVTDSPEIVQFVKDKAAEAGLVK 118 HVHLR+PGFE+KE I TG RSAAKGGFTTIACMPNTRP D+PE V+++ DK A G+VK Sbjct: 63 HVHLRDPGFEYKEDIATGTRSAAKGGFTTIACMPNTRPAVDTPETVKYILDKNAAEGVVK 122 Query: 119 VLPYAAITKNELGRELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAMKIAAGLDMPVIAH 178 VLPYAAITKN+LGRELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAM +A ++MP+IAH Sbjct: 123 VLPYAAITKNQLGRELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAMALAESMNMPIIAH 182 Query: 179 CEDNSLVEGCAVAEGTFAAKHGLRGIPNESEAIHVGRDILLAEATGVHYHVCHVSTEQSV 238 CEDN+LVEG V+EG+F+ KHGL+GIPNESEAIHVGRD+LL+EATG HYHVCHVSTEQSV Sbjct: 183 CEDNTLVEGLYVSEGSFSRKHGLKGIPNESEAIHVGRDVLLSEATGAHYHVCHVSTEQSV 242 Query: 239 RLIRQAKEIGIKVTAEVCPHHLLLSEEDIPGLDAXXXXKTPPPLRSRRDVEACIAGLLDG 298 RLIR AK+IG++VTAEVCPHHL+LS+EDIPG D+ K PPLR+ RDVEA I L DG Sbjct: 243 RLIRLAKQIGVRVTAEVCPHHLVLSDEDIPGFDS--NWKMNPPLRTPRDVEAVIEALEDG 300 Query: 299 TIDIIVTDHAPHSEEEKAKGMQLAPFGIVGFETAFPLLYTAFVATGKWDLSLLVQRMTAD 358 TID+IVTDHAPHS EEKA+ MQLAPFGIVGFETAFPLLYT FV TGKW L L+ RMTAD Sbjct: 301 TIDMIVTDHAPHSAEEKARDMQLAPFGIVGFETAFPLLYTKFVQTGKWTLGFLLDRMTAD 360 Query: 359 PARVFRLNTGSLTVGLPADLTLIDLTEEKEVDPASFASKGRNTPFGGWKLKGWPVKTWVN 418 PARVF L TG + G PADLT++DL E+ VDP++FASK NTPFGGWKL+GWPV T V+ Sbjct: 361 PARVFGLPTGRIKAGAPADLTIVDLDNERAVDPSTFASKSNNTPFGGWKLQGWPVATIVD 420 Query: 419 GTAVWTE 425 G V+ E Sbjct: 421 GKIVYNE 427 >Q9K9V7.1 PYRC_BACHD Dihydroorotase EC=3.5.2.3 Length = 428 Score = 534 bits (1375), Expect = e-150, Method: Compositional matrix adjust. Identities = 260/425 (61%), Positives = 321/425 (75%), Gaps = 4/425 (0%) Query: 2 IIKNASVLNGEGVLERKHIVVQDGIISAIKDGSEAVDEAGEIVEAEGKLLIPGLIDMHVH 61 +IKN S++ EG ++ + +++ DG+ISAI E D ++EA GKL+ PGL+D+HVH Sbjct: 4 LIKNGSIVTKEGTVKTQDVLLHDGVISAIGLNLEETD--AHVIEANGKLVTPGLVDLHVH 61 Query: 62 LREPGFEHKETIETGARSAAKGGFTTIACMPNTRPVTDSPEIVQFVKDKAAEAGLVKVLP 121 LREPG E KETIETG ++AAKGGFTT+A MPNTRPV DS E + ++ + E G+V+VLP Sbjct: 62 LREPGGEAKETIETGTKAAAKGGFTTVAAMPNTRPVPDSAEQMSWLTGRIDETGVVRVLP 121 Query: 122 YAAITKNELGRELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAMKIAAGLDMPVIAHCED 181 YAAIT +LGRELTDFA LKEAGA FTDDGVGVQSA MM +AMK AA L+M ++AHCE+ Sbjct: 122 YAAITTRQLGRELTDFAKLKEAGAFAFTDDGVGVQSAAMMLEAMKEAAKLEMAIVAHCEE 181 Query: 182 NSLVEGCAVAEGTFAAKHGLRGIPNESEAIHVGRDILLAEATGVHYHVCHVSTEQSVRLI 241 N+L++ +V EG F+ KHG+ GIP+ E++H+ RD+LLAEA GVHYHVCH+ST++SVR++ Sbjct: 182 NTLIQNGSVHEGVFSKKHGIAGIPSVCESVHIARDVLLAEAAGVHYHVCHISTKESVRVV 241 Query: 242 RQAKEIGIKVTAEVCPHHLLLSEEDIPGLDAXXXXKTPPPLRSRRDVEACIAGLLDGTID 301 R AK GI+VTAEV PHHLLL +EDIPGLDA K PPLR + D EA I GLLDGTID Sbjct: 242 RDAKRAGIRVTAEVTPHHLLLCDEDIPGLDA--HYKMNPPLRGKEDREALIEGLLDGTID 299 Query: 302 IIVTDHAPHSEEEKAKGMQLAPFGIVGFETAFPLLYTAFVATGKWDLSLLVQRMTADPAR 361 I TDHAPH+EEEK +GM+ APFGIVG ETAFPLLYT FV G + L LV +T DPA Sbjct: 300 FIATDHAPHTEEEKGQGMERAPFGIVGLETAFPLLYTHFVKKGTFTLKQLVDWLTIDPAE 359 Query: 362 VFRLNTGSLTVGLPADLTLIDLTEEKEVDPASFASKGRNTPFGGWKLKGWPVKTWVNGTA 421 F+L G L G PAD+T+IDL E+ +DPA FASKGRNTPF GW +GWPV T V G Sbjct: 360 TFQLPYGRLEEGAPADVTIIDLEAERAIDPAHFASKGRNTPFAGWTCQGWPVATLVGGKL 419 Query: 422 VWTEE 426 VW E+ Sbjct: 420 VWEEK 424 >Q5L0U5.1 PYRC_GEOKA Dihydroorotase EC=3.5.2.3 Length = 428 Score = 509 bits (1312), Expect = e-142, Method: Compositional matrix adjust. Identities = 256/425 (60%), Positives = 314/425 (73%), Gaps = 6/425 (1%) Query: 1 VIIKNASVLNGEGVLERKHIVVQDGIISAI--KDGSEAVDEAGEIVEAEGKLLIPGLIDM 58 V +KN N +G L R HI ++ G I+AI + EA +E ++++ G+L++PGLID+ Sbjct: 3 VWLKNGMSFNKDGELMRTHIKIEHGTIAAILYEQPLEANEE--DVIDVGGRLIVPGLIDL 60 Query: 59 HVHLREPGFEHKETIETGARSAAKGGFTTIACMPNTRPVTDSPEIVQFVKDKAAEAGLVK 118 HVHLREPG E KETIETG +AAKGGFTT+A MPNT P D E +++++ + E V Sbjct: 61 HVHLREPGGEAKETIETGTLAAAKGGFTTVAAMPNTNPAPDRKEQMEWLQARIRETARVN 120 Query: 119 VLPYAAITKNELGRELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAMKIAAGLDMPVIAH 178 VLPYAAIT + G ELTDFAALKEAGA FTDDGVGVQSA MM +AMK AA LDM ++AH Sbjct: 121 VLPYAAITIGQKGEELTDFAALKEAGAFAFTDDGVGVQSAGMMFEAMKQAAALDMAIVAH 180 Query: 179 CEDNSLVEGCAVAEGTFAAKHGLRGIPNESEAIHVGRDILLAEATGVHYHVCHVSTEQSV 238 CED++L G AV +G FA ++GLRGIP+ EA+H+ RD+LLAEA G HYHVCH+ST++SV Sbjct: 181 CEDDTLTNGGAVHDGEFARRYGLRGIPSVCEAVHIARDVLLAEAAGCHYHVCHISTKESV 240 Query: 239 RLIRQAKEIGIKVTAEVCPHHLLLSEEDIPGLDAXXXXKTPPPLRSRRDVEACIAGLLDG 298 R++R AK GI+VTAEV PHHLLL +EDIPGLDA K PPLRSR D +A I GLLDG Sbjct: 241 RVVRDAKRAGIRVTAEVTPHHLLLCDEDIPGLDA--NYKMNPPLRSREDRDALIEGLLDG 298 Query: 299 TIDIIVTDHAPHSEEEKAKGMQLAPFGIVGFETAFPLLYTAFVATGKWDLSLLVQRMTAD 358 TID I TDHAPH+ EKAKG++ APFGIVG ETAFPLLYT FV TG + L LV +T Sbjct: 299 TIDFIATDHAPHTAAEKAKGIEAAPFGIVGLETAFPLLYTHFVKTGVFTLKQLVDWLTIK 358 Query: 359 PARVFRLNTGSLTVGLPADLTLIDLTEEKEVDPASFASKGRNTPFGGWKLKGWPVKTWVN 418 PA+ F L G L VG PAD+ +IDL E+ +DP +FASKG+NTPF GW +GWPV T+V Sbjct: 359 PAQCFGLKAGRLAVGAPADIAVIDLETEEAIDPETFASKGKNTPFAGWVCQGWPVMTFVG 418 Query: 419 GTAVW 423 GT VW Sbjct: 419 GTLVW 423 >P46538.1 PYRC_BACCL Dihydroorotase EC=3.5.2.3 Length = 427 Score = 509 bits (1311), Expect = e-142, Method: Compositional matrix adjust. Identities = 257/424 (60%), Positives = 312/424 (73%), Gaps = 5/424 (1%) Query: 1 VIIKNASVLNGEGVLERKHIVVQDGIISAIKDGSEAVDEAGE-IVEAEGKLLIPGLIDMH 59 V +KN N +G L R HI ++ G I+AI E EA E +++ G+L++PGLID+H Sbjct: 3 VWLKNGMSFNKDGELMRTHIKIEHGTIAAIL--YEQPLEANEDVIDVGGRLIVPGLIDLH 60 Query: 60 VHLREPGFEHKETIETGARSAAKGGFTTIACMPNTRPVTDSPEIVQFVKDKAAEAGLVKV 119 VHLREPG E KETIETG +AAKGGFTT+A MPNT P D E +++++ + E V V Sbjct: 61 VHLREPGGEAKETIETGTLAAAKGGFTTVAAMPNTNPAPDRKEQMEWLQARIRETARVNV 120 Query: 120 LPYAAITKNELGRELTDFAALKEAGAIGFTDDGVGVQSAQMMKDAMKIAAGLDMPVIAHC 179 LPYAAIT + G ELTDFAALKEAGA FTDDGVGVQSA MM +AMK AA LDM ++AHC Sbjct: 121 LPYAAITIGQKGEELTDFAALKEAGAFAFTDDGVGVQSAGMMFEAMKQAAALDMAIVAHC 180 Query: 180 EDNSLVEGCAVAEGTFAAKHGLRGIPNESEAIHVGRDILLAEATGVHYHVCHVSTEQSVR 239 ED++L G AV +G FA ++GLRGIP+ EA+H+ RD+LLAEA G HYHVCH+ST++SVR Sbjct: 181 EDDTLTNGGAVHDGEFARRYGLRGIPSVCEAVHIARDVLLAEAAGCHYHVCHISTKESVR 240 Query: 240 LIRQAKEIGIKVTAEVCPHHLLLSEEDIPGLDAXXXXKTPPPLRSRRDVEACIAGLLDGT 299 ++R AK GI+VTAEV PHHLLL +EDIPGLDA K PPLRSR D +A I GLLDGT Sbjct: 241 VVRDAKRAGIRVTAEVTPHHLLLCDEDIPGLDA--NYKMNPPLRSREDRDALIEGLLDGT 298 Query: 300 IDIIVTDHAPHSEEEKAKGMQLAPFGIVGFETAFPLLYTAFVATGKWDLSLLVQRMTADP 359 ID I TDHAPH+ EKAKG++ APFGIVG ETAFPLLYT FV TG + L LV +T P Sbjct: 299 IDFIATDHAPHTAAEKAKGIEAAPFGIVGLETAFPLLYTHFVKTGVFTLKQLVDWLTIKP 358 Query: 360 ARVFRLNTGSLTVGLPADLTLIDLTEEKEVDPASFASKGRNTPFGGWKLKGWPVKTWVNG 419 A+ F L G L VG PAD+ +IDL E+ +DP +FASKG+NTPF GW +GWPV T+V G Sbjct: 359 AQCFGLKAGRLAVGAPADIAVIDLETEEAIDPETFASKGKNTPFAGWVCQGWPVMTFVGG 418 Query: 420 TAVW 423 T VW Sbjct: 419 TLVW 422 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.317 0.135 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,516,635,835 Number of extensions: 103952569 Number of successful extensions: 277108 Number of sequences better than 1.0e-05: 2251 Number of HSP's gapped: 271711 Number of HSP's successfully gapped: 2356 Length of query: 426 Length of database: 3,060,696,203 Length adjustment: 138 Effective length of query: 288 Effective length of database: 1,760,596,133 Effective search space: 507051686304 Effective search space used: 507051686304 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 133 (55.8 bits)