BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0247.0034.p (417 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KL57.1 B3KL57_9BACI 3,4-dihydroxy-2-butanone 4-phosphate synth... 705 0.0 C5D3N0.1 C5D3N0_9BACI 3,4-dihydroxy-2-butanone 4-phosphate synth... 628 e-178 B7GKI0.1 B7GKI0_ANOFW 3,4-dihydroxy-2-butanone 4-phosphate synth... 625 e-177 Q9KCL5.1 Q9KCL5_BACHD GTP cyclohydrolase II / 3, 4-dihydroxy-2-b... 618 e-175 A4IQG8.1 A4IQG8_GEOTN GTP cyclohydrolase II / 3, 4-dihydroxy-2-b... 617 e-175 >B3KL57.1 B3KL57_9BACI 3,4-dihydroxy-2-butanone 4-phosphate synthase EC=3.5.4.25 Length = 412 Score = 705 bits (1820), Expect = 0.0, Method: Compositional matrix adjust. Identities = 333/402 (82%), Positives = 372/402 (92%) Query: 14 IEDAIYDLMRGKVIIVVDDEDRENEGDFIALAERSTPEVINFMITEGRGLVCVPITAERA 73 IE+A+ DL GKV+IVVDDEDRENEGDFIALA+++TPEVINFMITEGRGLVC+P+T RA Sbjct: 10 IEEALSDLKEGKVVIVVDDEDRENEGDFIALADKATPEVINFMITEGRGLVCLPMTQTRA 69 Query: 74 AELDLQPMVAHNTDNHGTAFTVSVDHKDTTTGISAAERSKTIQALMDPEAKPSDFRRPGH 133 ELDL+PMV NTD HGTAFTVS+DHKDTTTGISA ERS T+ ++DP A +DFRRPGH Sbjct: 70 QELDLKPMVTQNTDYHGTAFTVSIDHKDTTTGISAYERSITVNGILDPNASAADFRRPGH 129 Query: 134 MFPLIAKKGGVLRRSGHTEAAVDLARMCGAYPASVICEVVKEDGTMARLPDLVEIARKHE 193 MFPLIAK GGVLRR+GHTEAAVDLAR+ G+YPA VICEV+KEDGTMARLPDLVEIA+KH+ Sbjct: 130 MFPLIAKDGGVLRRAGHTEAAVDLARLSGSYPAGVICEVIKEDGTMARLPDLVEIAKKHD 189 Query: 194 LKLISIKDLIHYRNEKEQLVTREVSVKLPTDFGDFQTIAYTNEVDDKEHVALVKGDISGE 253 LKLISIKDLIHYRNEKE+LV REV+V++PTD+G FQ +AYTN+VD+KEHVALVKG+I Sbjct: 190 LKLISIKDLIHYRNEKEKLVQREVAVRMPTDYGVFQAVAYTNDVDNKEHVALVKGEIDPS 249 Query: 254 EPVLVRVHSECLTGDVFHSHRCDCGPQFEAALRQIEAAGRGVLLYMRQEGRGIGLINKLR 313 EPVLVRVHSECLTGDVFHSHRCDCGPQFEAALRQI+ AGRGVLLYMRQEGRGIGLINKL+ Sbjct: 250 EPVLVRVHSECLTGDVFHSHRCDCGPQFEAALRQIDEAGRGVLLYMRQEGRGIGLINKLK 309 Query: 314 AYKLQEEGLDTVDANLKLGFPADLRDYGIGAQILKDLGVRQIKLMTNNPRKIKGLEGYGL 373 AYKLQEEGLDTVDANLKLGF ADLRDYGIGAQILKDLGVR+I+L+TNNPRKIKGLEGYGL Sbjct: 310 AYKLQEEGLDTVDANLKLGFAADLRDYGIGAQILKDLGVRKIRLLTNNPRKIKGLEGYGL 369 Query: 374 EVVERVPIQMPENKDNTNYLHTKQAKLGHLLTFDNIEQNEDS 415 EVVERVPIQMPEN+DNT YLHTKQAKLGH+L F++IEQNE + Sbjct: 370 EVVERVPIQMPENEDNTGYLHTKQAKLGHMLKFNDIEQNESA 411 >C5D3N0.1 C5D3N0_9BACI 3,4-dihydroxy-2-butanone 4-phosphate synthase EC=3.5.4.25 Length = 397 Score = 628 bits (1619), Expect = e-178, Method: Compositional matrix adjust. Identities = 303/397 (76%), Positives = 345/397 (86%) Query: 10 VLDPIEDAIYDLMRGKVIIVVDDEDRENEGDFIALAERSTPEVINFMITEGRGLVCVPIT 69 + D IE+AIY+LM+GKVIIV DDEDRENEGDF+ALAE++TPEVINFMI GRGLVCVPIT Sbjct: 1 MFDMIEEAIYELMQGKVIIVCDDEDRENEGDFVALAEKATPEVINFMIKYGRGLVCVPIT 60 Query: 70 AERAAELDLQPMVAHNTDNHGTAFTVSVDHKDTTTGISAAERSKTIQALMDPEAKPSDFR 129 E A +LDL PMV HNTD+HGTAFTVS+D+K TTTGISA ERS TIQAL+DP AK SDF+ Sbjct: 61 EELADKLDLAPMVNHNTDSHGTAFTVSIDYKSTTTGISAYERSMTIQALLDPNAKASDFK 120 Query: 130 RPGHMFPLIAKKGGVLRRSGHTEAAVDLARMCGAYPASVICEVVKEDGTMARLPDLVEIA 189 RPGH+FPL+AKKGGVLRR+GHTEAAVDLAR+CGA PA VICE++KEDGTMAR+ DL +IA Sbjct: 121 RPGHVFPLVAKKGGVLRRAGHTEAAVDLARLCGAKPAGVICEIIKEDGTMARVSDLRKIA 180 Query: 190 RKHELKLISIKDLIHYRNEKEQLVTREVSVKLPTDFGDFQTIAYTNEVDDKEHVALVKGD 249 + +LK+I+IKDLI YR KE+LV REV V LPT+FG F+ I YTN VD KEHVALVKG+ Sbjct: 181 DEFDLKMITIKDLIEYRRRKEKLVKREVEVMLPTEFGKFKAIGYTNIVDGKEHVALVKGE 240 Query: 250 ISGEEPVLVRVHSECLTGDVFHSHRCDCGPQFEAALRQIEAAGRGVLLYMRQEGRGIGLI 309 I +EP LVRVHSECLTGDVF S RCDCGPQ AALRQIE GRGVLLYMRQEGRGIGLI Sbjct: 241 IIPDEPTLVRVHSECLTGDVFGSCRCDCGPQLHAALRQIEEEGRGVLLYMRQEGRGIGLI 300 Query: 310 NKLRAYKLQEEGLDTVDANLKLGFPADLRDYGIGAQILKDLGVRQIKLMTNNPRKIKGLE 369 NKLRAYKLQE+G DTV+AN +LGFPADLRDYGIGAQILKDLGV +++L+TNNPRKI GL+ Sbjct: 301 NKLRAYKLQEQGYDTVEANERLGFPADLRDYGIGAQILKDLGVTKMRLLTNNPRKITGLK 360 Query: 370 GYGLEVVERVPIQMPENKDNTNYLHTKQAKLGHLLTF 406 G+GLEVVERVP+QMP NK+N YL TK KLGH+L F Sbjct: 361 GHGLEVVERVPLQMPANKENEKYLRTKYEKLGHMLHF 397 >B7GKI0.1 B7GKI0_ANOFW 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II Length = 400 Score = 625 bits (1613), Expect = e-177, Method: Compositional matrix adjust. Identities = 296/398 (74%), Positives = 344/398 (86%) Query: 9 SVLDPIEDAIYDLMRGKVIIVVDDEDRENEGDFIALAERSTPEVINFMITEGRGLVCVPI 68 ++ IE+AIYDLM+GK+IIV DDEDRENEGDF+ALAE++TPEVINFMIT GRGLVCVPI Sbjct: 3 AMFHTIEEAIYDLMQGKIIIVCDDEDRENEGDFVALAEKATPEVINFMITHGRGLVCVPI 62 Query: 69 TAERAAELDLQPMVAHNTDNHGTAFTVSVDHKDTTTGISAAERSKTIQALMDPEAKPSDF 128 T E A LDL PMV HNTD HGTAFTVS+DHK TTTGISA ERS TIQ +++PEAK SDF Sbjct: 63 TEELADRLDLTPMVNHNTDAHGTAFTVSIDHKATTTGISAFERSLTIQEMLNPEAKASDF 122 Query: 129 RRPGHMFPLIAKKGGVLRRSGHTEAAVDLARMCGAYPASVICEVVKEDGTMARLPDLVEI 188 +RPGH+FPL+AKKGGVLRR+GHTEAAVDLAR+CGA PA VICE++K+DGTMAR+PDL +I Sbjct: 123 KRPGHIFPLVAKKGGVLRRAGHTEAAVDLARLCGAKPAGVICEIIKDDGTMARVPDLKKI 182 Query: 189 ARKHELKLISIKDLIHYRNEKEQLVTREVSVKLPTDFGDFQTIAYTNEVDDKEHVALVKG 248 A + ++K+I+IKDLI YRN KE+LV REV + LPTDFG+F+ I Y+N +D KEH+A+VKG Sbjct: 183 AEQFDMKMITIKDLIAYRNRKEKLVKREVEITLPTDFGEFKVIGYSNTLDGKEHIAIVKG 242 Query: 249 DISGEEPVLVRVHSECLTGDVFHSHRCDCGPQFEAALRQIEAAGRGVLLYMRQEGRGIGL 308 +I +EPVLVRVHSECLTGDVF SHRCDCGPQ AAL QIE GRGVLLYMRQEGRGIGL Sbjct: 243 EIIPDEPVLVRVHSECLTGDVFGSHRCDCGPQLHAALAQIEEEGRGVLLYMRQEGRGIGL 302 Query: 309 INKLRAYKLQEEGLDTVDANLKLGFPADLRDYGIGAQILKDLGVRQIKLMTNNPRKIKGL 368 +NKLRAYKLQE+G DTV+AN KLGF DLRDYGIGAQILKDLGV +++L+TNNPRKI GL Sbjct: 303 LNKLRAYKLQEQGYDTVEANEKLGFAPDLRDYGIGAQILKDLGVTKMRLLTNNPRKITGL 362 Query: 369 EGYGLEVVERVPIQMPENKDNTNYLHTKQAKLGHLLTF 406 +GYGLEVVERVP+QMP + N YL TK KLGH+L F Sbjct: 363 KGYGLEVVERVPLQMPAKRHNERYLRTKYEKLGHMLHF 400 >Q9KCL5.1 Q9KCL5_BACHD GTP cyclohydrolase II / 3, 4-dihydroxy-2-butanone 4-phosphate synthase EC=3.5.4.25 EC=5.4.99.- Length = 404 Score = 618 bits (1594), Expect = e-175, Method: Compositional matrix adjust. Identities = 293/400 (73%), Positives = 342/400 (85%) Query: 7 NDSVLDPIEDAIYDLMRGKVIIVVDDEDRENEGDFIALAERSTPEVINFMITEGRGLVCV 66 + + DPIE+AIY+LM+G+V+IV DDEDRENEGDF+ALAE++TPEVINFMIT GRGLVC Sbjct: 2 DKKLFDPIEEAIYELMQGRVVIVCDDEDRENEGDFVALAEKATPEVINFMITHGRGLVCT 61 Query: 67 PITAERAAELDLQPMVAHNTDNHGTAFTVSVDHKDTTTGISAAERSKTIQALMDPEAKPS 126 PIT ERA ELDL PMV HNTD HGTAFTVS+DH+ TTTGISA ER+ TIQAL+D + K Sbjct: 62 PITEERAKELDLVPMVDHNTDPHGTAFTVSIDHQMTTTGISAHERAMTIQALIDKKTKKH 121 Query: 127 DFRRPGHMFPLIAKKGGVLRRSGHTEAAVDLARMCGAYPASVICEVVKEDGTMARLPDLV 186 F+RPGH+FPLIAK GGVLRR+GHTEAAVDLAR+ GA PA VICE++KEDG+MAR+PDL Sbjct: 122 HFKRPGHIFPLIAKNGGVLRRAGHTEAAVDLARLSGAEPAGVICEIIKEDGSMARVPDLR 181 Query: 187 EIARKHELKLISIKDLIHYRNEKEQLVTREVSVKLPTDFGDFQTIAYTNEVDDKEHVALV 246 +IA + ELK+I+IKDLI YR+ K++LV REV + LPTDFG F+ I YT+ +D KE VALV Sbjct: 182 KIADQFELKMITIKDLIEYRHRKDKLVKREVDISLPTDFGSFRAIGYTDVIDGKESVALV 241 Query: 247 KGDISGEEPVLVRVHSECLTGDVFHSHRCDCGPQFEAALRQIEAAGRGVLLYMRQEGRGI 306 KG I EP LVRVHSECLTGDVF SHRCDCGPQ +AAL QIE G+G+LLYMRQEGRGI Sbjct: 242 KGQIVEGEPTLVRVHSECLTGDVFGSHRCDCGPQLQAALTQIEQQGKGILLYMRQEGRGI 301 Query: 307 GLINKLRAYKLQEEGLDTVDANLKLGFPADLRDYGIGAQILKDLGVRQIKLMTNNPRKIK 366 GL+NKL+AYKLQEEG DTV+AN KLGFPADLRDYG+GAQIL+DLGV +++L+TNNPRKI Sbjct: 302 GLMNKLKAYKLQEEGYDTVEANEKLGFPADLRDYGMGAQILRDLGVSKMRLLTNNPRKIT 361 Query: 367 GLEGYGLEVVERVPIQMPENKDNTNYLHTKQAKLGHLLTF 406 GL+GYGLEVVERVP+Q+P NKDN YL TK KLGHLL F Sbjct: 362 GLKGYGLEVVERVPLQLPHNKDNERYLKTKHEKLGHLLNF 401 >A4IQG8.1 A4IQG8_GEOTN GTP cyclohydrolase II / 3, 4-dihydroxy-2-butanone4-phosphate synthase Length = 399 Score = 617 bits (1592), Expect = e-175, Method: Compositional matrix adjust. Identities = 295/398 (74%), Positives = 344/398 (86%) Query: 9 SVLDPIEDAIYDLMRGKVIIVVDDEDRENEGDFIALAERSTPEVINFMITEGRGLVCVPI 68 ++ D IE A+ L G+VIIV DDEDRENEGDF+ALAE++TP+VINFMIT GRGLVCVPI Sbjct: 2 AMFDTIEAALAALKNGEVIIVCDDEDRENEGDFVALAEKATPDVINFMITHGRGLVCVPI 61 Query: 69 TAERAAELDLQPMVAHNTDNHGTAFTVSVDHKDTTTGISAAERSKTIQALMDPEAKPSDF 128 T E AA L+L+PMVAHNTD HGTAFTVSVD+K TTTGISA ER+ TIQAL+DP K SDF Sbjct: 62 TEELAARLELEPMVAHNTDAHGTAFTVSVDYKTTTTGISAYERAATIQALLDPNVKASDF 121 Query: 129 RRPGHMFPLIAKKGGVLRRSGHTEAAVDLARMCGAYPASVICEVVKEDGTMARLPDLVEI 188 +RPGH+FPLIAKKGGVLRR+GHTEAAVDLAR+CGA PA VICE++KEDGTMAR+PDL I Sbjct: 122 KRPGHIFPLIAKKGGVLRRAGHTEAAVDLARLCGAKPAGVICEIIKEDGTMARVPDLRHI 181 Query: 189 ARKHELKLISIKDLIHYRNEKEQLVTREVSVKLPTDFGDFQTIAYTNEVDDKEHVALVKG 248 A + LK+I+IKDLI YR+++E+LV REV + LPT+FG+F+ I YTN +D KEHVALVKG Sbjct: 182 ADQFGLKMITIKDLIAYRSQREKLVKREVEISLPTEFGEFRAIGYTNILDGKEHVALVKG 241 Query: 249 DISGEEPVLVRVHSECLTGDVFHSHRCDCGPQFEAALRQIEAAGRGVLLYMRQEGRGIGL 308 +I ++ +LVRVHSECLTGDVF S+RCDCGPQ AALRQIEA G GVLLYMRQEGRGIGL Sbjct: 242 EIVPDKAILVRVHSECLTGDVFGSYRCDCGPQLHAALRQIEAEGNGVLLYMRQEGRGIGL 301 Query: 309 INKLRAYKLQEEGLDTVDANLKLGFPADLRDYGIGAQILKDLGVRQIKLMTNNPRKIKGL 368 +NKLRAYKLQE+G DTV+AN KLGFPADLRDYGIGAQILKDLGV +++L+TNNPRKI GL Sbjct: 302 MNKLRAYKLQEQGYDTVEANEKLGFPADLRDYGIGAQILKDLGVTKMRLLTNNPRKIAGL 361 Query: 369 EGYGLEVVERVPIQMPENKDNTNYLHTKQAKLGHLLTF 406 +G+GLEVVERVP+QMP K+N YL TK KLGH+L F Sbjct: 362 KGHGLEVVERVPLQMPPTKENEKYLRTKYEKLGHMLHF 399 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.318 0.137 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,489,617,436 Number of extensions: 106083153 Number of successful extensions: 273381 Number of sequences better than 1.0e-05: 2573 Number of HSP's gapped: 269479 Number of HSP's successfully gapped: 2574 Length of query: 417 Length of database: 3,060,696,203 Length adjustment: 138 Effective length of query: 279 Effective length of database: 1,760,596,133 Effective search space: 491206321107 Effective search space used: 491206321107 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 132 (55.5 bits)