BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0244.0003.p (355 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KLB0.1 B3KLB0_9BACI Uroporphyrinogen decarboxylase EC=4.1.1.37 598 e-169 B1DL26.1 B1DL26_9BACL Uroporphyrinogen decarboxylase EC=4.1.1.37 569 e-160 A7GM02.2 DCUP_BACCN Uroporphyrinogen decarboxylase EC=4.1.1.37 405 e-111 C0ZAI2.1 C0ZAI2_BREBN Uroporphyrinogen decarboxylase EC=4.1.1.37 402 e-110 A4IKU7.1 DCUP_GEOTN Uroporphyrinogen decarboxylase EC=4.1.1.37 398 e-109 >B3KLB0.1 B3KLB0_9BACI Uroporphyrinogen decarboxylase EC=4.1.1.37 Length = 352 Score = 598 bits (1541), Expect = e-169, Method: Compositional matrix adjust. Identities = 279/350 (79%), Positives = 320/350 (91%) Query: 1 MTYNDTFIRACRKQDTDHIPVWYMRQAGRYDPEYRKIKENYSLLEICEQPELAAEVTMMP 60 MTYND FIRACRKQ+ DH+PVWYMRQAGRYDPEYRKIKE YSLLEIC QPELAAEVT+MP Sbjct: 1 MTYNDQFIRACRKQEVDHVPVWYMRQAGRYDPEYRKIKEKYSLLEICSQPELAAEVTLMP 60 Query: 61 VRKLGVDAAILYSDIMNPVASLGVKFDIVKNIGPVIENPIRSAADVERLKPIDVEGDLSH 120 VRKLGVDAAILYSDIMNPVAS+GV FDIVKNIGPVI+NPIRSAADVE+L+PIDVEGDL H Sbjct: 61 VRKLGVDAAILYSDIMNPVASIGVDFDIVKNIGPVIDNPIRSAADVEKLRPIDVEGDLGH 120 Query: 121 ILKTIAILDKELDVPLITFAGAPFTIASYLIEGRPSKSYHRTKEMMYSQPQVWFMLMDKL 180 +L+TI ILDKELDVPLITFAGAPFTIASYLIEGRPSK+Y RTKE+MYS+P+VWF LMDKL Sbjct: 121 VLETIRILDKELDVPLITFAGAPFTIASYLIEGRPSKNYLRTKELMYSEPKVWFSLMDKL 180 Query: 181 GDMVIAYLRAHVASGGKAFQLFDSWVGALAPHDFELYVLPTISRIFAGLADLNVPKIYFP 240 GDMVIAYLRAHVA+GGKAFQLFDSWVGAL+P DF+ +VLPTI RIFA L DL+VPKIYFP Sbjct: 181 GDMVIAYLRAHVANGGKAFQLFDSWVGALSPKDFQTFVLPTIQRIFAELQDLSVPKIYFP 240 Query: 241 GVSSGELLPSLAHLQADVIGLDWRVSLTEGRRRIGGRFAVQGNLDPYLLTAPLDLLKERA 300 GVSSGELLP+L L DVIGLDWRVS+TEGRRR+ ++AVQGNLDP +LT P+ ++++ A Sbjct: 241 GVSSGELLPTLTDLSTDVIGLDWRVSITEGRRRLEHKYAVQGNLDPTVLTGPMPVIQQYA 300 Query: 301 KALIDEGIREPGYIFNLGHGLFPEASLDTLKELTEYVHDYSREALKQTAK 350 K +ID+GI+EPG++FNLGHGLFPEASL+ L+ELT Y+H+YS +AL+ A+ Sbjct: 301 KEIIDQGIQEPGFVFNLGHGLFPEASLEKLRELTSYIHEYSAQALQAGAQ 350 >B1DL26.1 B1DL26_9BACL Uroporphyrinogen decarboxylase EC=4.1.1.37 Length = 356 Score = 569 bits (1467), Expect = e-160, Method: Compositional matrix adjust. Identities = 267/345 (77%), Positives = 307/345 (88%) Query: 1 MTYNDTFIRACRKQDTDHIPVWYMRQAGRYDPEYRKIKENYSLLEICEQPELAAEVTMMP 60 M+YND FIRACRK+ D +PVWYMRQAGRYDPEYRKIKE YSLLEIC+QPELAAEVTMMP Sbjct: 1 MSYNDRFIRACRKELVDTVPVWYMRQAGRYDPEYRKIKEKYSLLEICKQPELAAEVTMMP 60 Query: 61 VRKLGVDAAILYSDIMNPVASLGVKFDIVKNIGPVIENPIRSAADVERLKPIDVEGDLSH 120 VRKLGVDAAILYSDIMNPVAS+G+ FDIV NIGPVI NPIR+AADVERL PIDVEGDL H Sbjct: 61 VRKLGVDAAILYSDIMNPVASIGIDFDIVANIGPVIHNPIRTAADVERLTPIDVEGDLGH 120 Query: 121 ILKTIAILDKELDVPLITFAGAPFTIASYLIEGRPSKSYHRTKEMMYSQPQVWFMLMDKL 180 +L+TI ILDKEL+VPLITFAGAPFTIASYLIEG+PSK+Y RTK +MY +P+VWF LMDKL Sbjct: 121 VLETIRILDKELEVPLITFAGAPFTIASYLIEGKPSKNYLRTKALMYGEPKVWFSLMDKL 180 Query: 181 GDMVIAYLRAHVASGGKAFQLFDSWVGALAPHDFELYVLPTISRIFAGLADLNVPKIYFP 240 GDMVIAYLRAH+ASGGKAFQLFDSWVGAL P DF +VLPTI RIFA L+DL PKIYFP Sbjct: 181 GDMVIAYLRAHMASGGKAFQLFDSWVGALTPADFSKFVLPTIERIFAELSDLPQPKIYFP 240 Query: 241 GVSSGELLPSLAHLQADVIGLDWRVSLTEGRRRIGGRFAVQGNLDPYLLTAPLDLLKERA 300 GVSSGELLP L +L+ADVIGLDWRVS+ EGRRR+ G++AVQGNLDP +LTAP+ +++ A Sbjct: 241 GVSSGELLPELRNLKADVIGLDWRVSIPEGRRRLDGKYAVQGNLDPVILTAPMSVIESYA 300 Query: 301 KALIDEGIREPGYIFNLGHGLFPEASLDTLKELTEYVHDYSREAL 345 +ID+GI++PG++FNLGHGLFPEASL+ L ELT ++H YS +A+ Sbjct: 301 AEIIDQGIQQPGFVFNLGHGLFPEASLEKLTELTAFIHSYSEKAI 345 >A7GM02.2 DCUP_BACCN Uroporphyrinogen decarboxylase EC=4.1.1.37 Length = 348 Score = 405 bits (1040), Expect = e-111, Method: Compositional matrix adjust. Identities = 192/345 (55%), Positives = 255/345 (73%), Gaps = 3/345 (0%) Query: 4 NDTFIRACRKQDTDHIPVWYMRQAGRYDPEYRKIKENYSLLEICEQPELAAEVTMMPVRK 63 N+TF++AC+ + TD++P WYMRQAGR PEYRKIKE YSL EI PEL A VT +PV + Sbjct: 6 NETFLKACKGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQ 65 Query: 64 LGVDAAILYSDIMNPVASLGVKFDIVKNIGPVIENPIRSAADVERLKPIDVEGDLSHILK 123 VDAAILY DIM+P+ ++GV +I IGPVIENPIRS DVE+L I E D+ +IL Sbjct: 66 YNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIENPIRSMQDVEKLGEIHPEEDVPYILD 125 Query: 124 TIAILDKE-LDVPLITFAGAPFTIASYLIEGRPSKSYHRTKEMMYSQPQVWFMLMDKLGD 182 TI +L E LDVPLI F+GAPFT+ASY+IEG PS++YH+TK MY++P+ WF LMDKL D Sbjct: 126 TIRLLTAEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHKTKAFMYAEPKAWFALMDKLSD 185 Query: 183 MVIAYLRAHVASGGKAFQLFDSWVGALAPHDFELYVLPTISRIFAGLADLNVPKIYFPGV 242 MVIAYL+A + +G KA Q+FDSWVG + D+ +++ P + RIFA + ++NVP I GV Sbjct: 186 MVIAYLKAQIQAGAKAVQVFDSWVGTVNVADYRIFIKPAMERIFAQVREMNVPMIMH-GV 244 Query: 243 SSGELLPSLAHLQADVIGLDWRVSLTEGRRRIGGRFAVQGNLDPYLLTAPLDLLKERAKA 302 +G L L DV+GLDWR+S+ E R R G AVQGN+DP LL AP ++++E K Sbjct: 245 GAGHLANEWNDLPLDVVGLDWRLSIEEARTR-GIHKAVQGNMDPSLLLAPWNVIEEHVKG 303 Query: 303 LIDEGIREPGYIFNLGHGLFPEASLDTLKELTEYVHDYSREALKQ 347 ++D+G+++PGY+FNLGHG+FPE + DTLK LT ++H+YS+E L + Sbjct: 304 ILDQGMKQPGYVFNLGHGVFPEVNPDTLKRLTAFIHEYSKEQLAK 348 >C0ZAI2.1 C0ZAI2_BREBN Uroporphyrinogen decarboxylase EC=4.1.1.37 Length = 345 Score = 402 bits (1032), Expect = e-110, Method: Compositional matrix adjust. Identities = 188/342 (54%), Positives = 250/342 (73%), Gaps = 2/342 (0%) Query: 2 TYNDTFIRACRKQDTDHIPVWYMRQAGRYDPEYRKIKENYSLLEICEQPELAAEVTMMPV 61 T+NDTF++ACR + T+H+PVWYMRQAGRY PEYR I+ +S E+ PE+ AEVT +PV Sbjct: 5 TFNDTFLKACRGEATEHVPVWYMRQAGRYQPEYRAIRAKHSFFEMNYIPEVCAEVTRLPV 64 Query: 62 RKLGVDAAILYSDIMNPVASLGVKFDIVKNIGPVIENPIRSAADVERLKPIDVEGDLSHI 121 +LGVDAAIL++DIM P+ +GV +I IGPVI NPI S DVERL +D E + +I Sbjct: 65 EQLGVDAAILFADIMTPLKPIGVDVNIESGIGPVIANPIESLKDVERLLELDPETHVPYI 124 Query: 122 LKTIAILDKELDVPLITFAGAPFTIASYLIEGRPSKSYHRTKEMMYSQPQVWFMLMDKLG 181 L++I IL ++L VPLI FAGAPFT+ASYLIEG PSK YH+TK MY++P W LM+KLG Sbjct: 125 LESIKILRQQLSVPLIGFAGAPFTLASYLIEGGPSKHYHKTKAFMYTEPVAWQALMEKLG 184 Query: 182 DMVIAYLRAHVASGGKAFQLFDSWVGALAPHDFELYVLPTISRIFAGLADLNVPKIYFPG 241 DM I YL+A + +G +A Q+FDSWVGAL D+ Y+ P ++RIF L D VP IYF G Sbjct: 185 DMTITYLKAQIKAGAQAVQVFDSWVGALNDEDYREYITPVMTRIFNALKDTGVPTIYF-G 243 Query: 242 VSSGELLPSLAHLQADVIGLDWRVSLTEGRRRIGGRFAVQGNLDPYLLTAPLDLLKERAK 301 + +G LL L DV+GLDWR S+T R +G +QGNLDP LL AP + L+ +AK Sbjct: 244 IGAGHLLMDWNRLPVDVVGLDWRTSITTA-REMGVTKTLQGNLDPTLLLAPWEKLEAKAK 302 Query: 302 ALIDEGIREPGYIFNLGHGLFPEASLDTLKELTEYVHDYSRE 343 ++DEG ++PG+IFNLGHG+FP+A ++TL++LT+++H Y R+ Sbjct: 303 EILDEGTKQPGFIFNLGHGVFPDAKVETLQQLTKFIHRYKRD 344 >A4IKU7.1 DCUP_GEOTN Uroporphyrinogen decarboxylase EC=4.1.1.37 Length = 345 Score = 398 bits (1023), Expect = e-109, Method: Compositional matrix adjust. Identities = 191/339 (56%), Positives = 248/339 (73%), Gaps = 3/339 (0%) Query: 4 NDTFIRACRKQDTDHIPVWYMRQAGRYDPEYRKIKENYSLLEICEQPELAAEVTMMPVRK 63 NDTF+RACR + T ++PVWYMRQAGR PEYR +KE YSL EI QPEL A VT +PV + Sbjct: 6 NDTFLRACRGEKTAYVPVWYMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTRLPVEQ 65 Query: 64 LGVDAAILYSDIMNPVASLGVKFDIVKNIGPVIENPIRSAADVERLKPIDVEGDLSHILK 123 GVDAAILY DIM P+ ++GV +I +GPVI NPIRS DVERL ID E D+ ++L+ Sbjct: 66 YGVDAAILYKDIMTPLPAIGVDVEIRGGVGPVIANPIRSLHDVERLGEIDPEHDVPYVLE 125 Query: 124 TIAIL-DKELDVPLITFAGAPFTIASYLIEGRPSKSYHRTKEMMYSQPQVWFMLMDKLGD 182 TI +L +++LDVPLI FAGAPFT+ASY+IEG PSK+YH+TK MY++P+ WF LMDKL + Sbjct: 126 TIRLLVNEQLDVPLIGFAGAPFTLASYMIEGGPSKNYHKTKAFMYAEPKAWFALMDKLAE 185 Query: 183 MVIAYLRAHVASGGKAFQLFDSWVGALAPHDFELYVLPTISRIFAGLADLNVPKIYFPGV 242 M I Y++A + +G A Q+FDSWVGA+ D+ ++ P ++RIFA L + P I F GV Sbjct: 186 MTIRYVKAQIQAGASAVQIFDSWVGAVNADDYRTFIKPAMARIFAALREEGAPLIMF-GV 244 Query: 243 SSGELLPSLAHLQADVIGLDWRVSLTEGRRRIGGRFAVQGNLDPYLLTAPLDLLKERAKA 302 + L L DVIGLDWR+S+ E RRR G A+QGNLDP +L AP D+++ER K Sbjct: 245 GASHLAHEWNDLPLDVIGLDWRLSIREARRR-GITKAIQGNLDPAVLLAPWDVIEERVKR 303 Query: 303 LIDEGIREPGYIFNLGHGLFPEASLDTLKELTEYVHDYS 341 ++DEG+ +PGYIFNLGHG+FP+ TLK LT ++HDY+ Sbjct: 304 ILDEGMEQPGYIFNLGHGIFPDVQPATLKRLTAFIHDYT 342 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.322 0.140 0.415 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,193,186,685 Number of extensions: 94994823 Number of successful extensions: 214831 Number of sequences better than 1.0e-05: 1294 Number of HSP's gapped: 210610 Number of HSP's successfully gapped: 1295 Length of query: 355 Length of database: 3,060,696,203 Length adjustment: 137 Effective length of query: 218 Effective length of database: 1,770,017,148 Effective search space: 385863738264 Effective search space used: 385863738264 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 132 (55.5 bits)