BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0231.0039.p (649 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KB04.1 B3KB04_9BACI Radical SAM domain protein 906 0.0 B1DJL1.1 B1DJL1_9BACL Radical SAM domain protein 816 0.0 Q9K8Q1.1 Q9K8Q1_BACHD Mg-protoporphyrin IX monomethyl ester oxid... 797 0.0 C5D7G2.1 C5D7G2_9BACI Cobalamin B12-binding domain protein 733 0.0 A4ILK5.1 A4ILK5_GEOTN Mg-protoporphyrin IX monomethyl ester oxid... 723 0.0 >B3KB04.1 B3KB04_9BACI Radical SAM domain protein Length = 589 Score = 906 bits (2341), Expect = 0.0, Method: Compositional matrix adjust. Identities = 425/555 (76%), Positives = 483/555 (87%), Gaps = 1/555 (0%) Query: 1 MKIILATLNAKYIHTSLAIRLLKAYSEHEFQDIHLAEYTIKDPVMNIVSDLFQKKPDVIG 60 MK+IL+TLNAKYIHTSLAIR LKAYSE +F DI L EYTIKDPVMNIVSDLFQ+KPDVIG Sbjct: 1 MKVILSTLNAKYIHTSLAIRCLKAYSEKDF-DIELTEYTIKDPVMNIVSDLFQRKPDVIG 59 Query: 61 FSCYIWNIEETVKVIGILKQVMPEVTVVLGGPEVSYEPLYWMQREAGIDFVVNGDGEETF 120 FSCYIWNIEET+KVI I+K++MPEVT++LGGPEVSY+ YWM+R +DF+V G+GEETF Sbjct: 60 FSCYIWNIEETIKVIDIVKKIMPEVTIILGGPEVSYDTEYWMKRLHHVDFIVMGEGEETF 119 Query: 121 HHLLQELRDDRKFHFVYGAAYRKGEELIVNPPRPKSDLNTLPSPHRFPDDLPDLGKRIVY 180 HHLLQ + DRKFHFVYG AYRK +E+IVNP RPKS L LPSPHRFP+D+P LGKR+VY Sbjct: 120 HHLLQTIEGDRKFHFVYGVAYRKQDEIIVNPGRPKSILAELPSPHRFPEDIPHLGKRVVY 179 Query: 181 FETSRGCPFNCQFCLSSIEVGVRYYDIERVKADLLYLIENGAKVIKFLDRTFNINRNYAM 240 FETSRGCPF+CQFCLSSIEVGVRYYDIER KAD+LYLIENGAK+IKF+DRTFNI R+YA+ Sbjct: 180 FETSRGCPFSCQFCLSSIEVGVRYYDIERTKADILYLIENGAKLIKFVDRTFNIKRDYAL 239 Query: 241 EMFQFLIDNHQGCVFQFEITADIMRPEVLDFLAEHAPPGIFRFEIGVQSTNDETNELVKR 300 EMF+FLI+NH GCVFQFEITADIMRPEVL++LA HAPPGIFRFEIGVQSTND TNELVKR Sbjct: 240 EMFEFLIENHGGCVFQFEITADIMRPEVLEYLANHAPPGIFRFEIGVQSTNDPTNELVKR 299 Query: 301 RQNFTKLSRTVMKIKASGNIDQHLDLIAGLPQEDYATFRKTFNDVFAMEPEELQLGFLKM 360 RQNFTKLSRTV IK S IDQHLDLIAGLP+EDY TFRKTFNDVFA+ PEELQLGFLKM Sbjct: 300 RQNFTKLSRTVTMIKESRKIDQHLDLIAGLPEEDYITFRKTFNDVFALGPEELQLGFLKM 359 Query: 361 LRGTGLRAQAAKYNYTYMEHAPYEILSSHVMPFSDIIRLKRLEDVLEKYWTSHRLDHSVK 420 LRGTGLR A KYNYTYM+HAPYEIL S V+PFSDI+RLKRLEDVLEKYW +HR+DH++ Sbjct: 360 LRGTGLRIDADKYNYTYMDHAPYEILGSDVLPFSDIVRLKRLEDVLEKYWNAHRMDHTLN 419 Query: 421 YLIRHVFQSPFDFFQEFGDYWEARGWQKIGHQLEDLFTRLHAFLTDRRTPSMPVITGLMK 480 YL++H F SPFDFFQEFGDYWE +GWQKIGHQLEDLFTRL AFL R TP+M V++GLMK Sbjct: 420 YLMKHEFTSPFDFFQEFGDYWEGQGWQKIGHQLEDLFTRLTAFLEFRNTPNMNVVSGLMK 479 Query: 481 LDYFLGHKYKPRKIWWDITLDKPEWSHYMKEIAEHPERLSAKLADAGFSERELQKFTVLE 540 DYFLGHKYKPRKIWWD DK +W+ +++I E P LSA AD G +ER+LQK ++E Sbjct: 480 FDYFLGHKYKPRKIWWDHAQDKAQWNANVRKIVEDPAALSADFADLGITERDLQKHAMIE 539 Query: 541 VLPFRLEAVLDSISG 555 VLPF L+ + +G Sbjct: 540 VLPFNLDDAIQGGTG 554 >B1DJL1.1 B1DJL1_9BACL Radical SAM domain protein Length = 608 Score = 816 bits (2107), Expect = 0.0, Method: Compositional matrix adjust. Identities = 378/565 (66%), Positives = 463/565 (81%), Gaps = 14/565 (2%) Query: 1 MKIILATLNAKYIHTSLAIRLLKAYSEHEFQDIHLAEYTIKDPVMNIVSDLFQKKPDVIG 60 MK++L+TLNAKYIHTSLA+R LKAYS F D+ +AEYTIKDPVMNIVSD+F +KPDV+G Sbjct: 1 MKVVLSTLNAKYIHTSLALRCLKAYSGEHF-DMEIAEYTIKDPVMNIVSDIFSRKPDVVG 59 Query: 61 FSCYIWNIEETVKVIGILKQVMPEVTVVLGGPEVSYEPLYWMQREAGIDFVVNGDGEETF 120 FSCYIWNIEET+ VI +L+++MPE+ ++LGGPEVSY+ YWM+R + +DF+V G+GEETF Sbjct: 60 FSCYIWNIEETITVINMLRKIMPEIKIILGGPEVSYDTEYWMERISEVDFIVVGEGEETF 119 Query: 121 HHLLQELRDDRKFHFVYGAAYRKGEE----LIVNPPRPKSDLNTLPSPHRFPDDLPDLGK 176 HHLL E+ K+H V+G AYRK E +++NP RPK DL TLPSPHRF +D+P LG Sbjct: 120 HHLLTEIEGAGKYHMVFGIAYRKQREDRVEILLNPGRPKLDLATLPSPHRFEEDIPHLGS 179 Query: 177 RIVYFETSRGCPFNCQFCLSSIEVGVRYYDIERVKADLLYLIENGAKVIKFLDRTFNINR 236 R+VYFETSRGCPF+CQFCLSSIEVGVRY+D+ER KAD+ YLI++GAK+IKF+DRTFNI R Sbjct: 180 RVVYFETSRGCPFSCQFCLSSIEVGVRYFDMERTKADITYLIDSGAKLIKFVDRTFNIKR 239 Query: 237 NYAMEMFQFLIDNHQGCVFQFEITADIMRPEVLDFLAEHAPPGIFRFEIGVQSTNDETNE 296 +YA+EMF+FLI+NH+GCVFQFEITADIMRPEVLD+LAEHAPPG+FRFEIGVQSTND TNE Sbjct: 240 DYALEMFKFLIENHRGCVFQFEITADIMRPEVLDYLAEHAPPGVFRFEIGVQSTNDPTNE 299 Query: 297 LVKRRQNFTKLSRTVMKIKASGNIDQHLDLIAGLPQEDYATFRKTFNDVFAMEPEELQLG 356 V+RRQN+ KL RTV K+K SG IDQHLDLIAGLP E+Y TFR TFNDVF + PEELQLG Sbjct: 300 AVQRRQNWKKLVRTVTKVKESGKIDQHLDLIAGLPLENYDTFRGTFNDVFELGPEELQLG 359 Query: 357 FLKMLRGTGLRAQAAKYNYTYMEHAPYEILSSHVMPFSDIIRLKRLEDVLEKYWTSHRLD 416 FLKMLRGTGLR A K+ Y YM+HAPYE+L + +MPF DI+R+KR+EDVLEKYW +HR+D Sbjct: 360 FLKMLRGTGLRRDADKWGYIYMDHAPYEMLGNELMPFGDIVRIKRVEDVLEKYWNAHRMD 419 Query: 417 HSVKYLIRHVFQSPFDFFQEFGDYWEARGWQKIGHQLEDLFTRLHAFLTDRRTPS----- 471 ++ YL+ VF SPFDFFQ FGD+WE RGWQKIGHQLEDLF+RL AFL++ + + Sbjct: 420 RTLGYLVNKVFPSPFDFFQYFGDFWEERGWQKIGHQLEDLFSRLWAFLSEYKAGAASEEA 479 Query: 472 ----MPVITGLMKLDYFLGHKYKPRKIWWDITLDKPEWSHYMKEIAEHPERLSAKLADAG 527 + V+ GLMK DYFL H YKPRK WW+ T++K EWS +M+ +AE PE +S AD Sbjct: 480 AKLDLDVVLGLMKYDYFLNHNYKPRKTWWEFTMEKSEWSGWMRRLAERPEEVSQAFADLQ 539 Query: 528 FSERELQKFTVLEVLPFRLEAVLDS 552 +E+EL K TV+E+LPF LE L + Sbjct: 540 LNEKELYKHTVIELLPFDLEHYLAT 564 >Q9K8Q1.1 Q9K8Q1_BACHD Mg-protoporphyrin IX monomethyl ester oxidative cyclase Length = 592 Score = 797 bits (2059), Expect = 0.0, Method: Compositional matrix adjust. Identities = 370/546 (67%), Positives = 448/546 (82%), Gaps = 1/546 (0%) Query: 1 MKIILATLNAKYIHTSLAIRLLKAYSEHEFQDIHLAEYTIKDPVMNIVSDLFQKKPDVIG 60 MK ++ TLNAKYIHT LA+R LKAY+E EF I + EYTIKDP MNIV+DL Q+KPDVIG Sbjct: 1 MKTVVTTLNAKYIHTCLALRCLKAYAEPEFP-IEMVEYTIKDPAMNIVADLHQRKPDVIG 59 Query: 61 FSCYIWNIEETVKVIGILKQVMPEVTVVLGGPEVSYEPLYWMQREAGIDFVVNGDGEETF 120 FSCYIWNI+ET++VI +LK+VMP V +VLGGPEVSY+ WM+R +DF+V G+GEETF Sbjct: 60 FSCYIWNIQETIQVIEMLKKVMPSVKIVLGGPEVSYDTREWMERLHAVDFIVVGEGEETF 119 Query: 121 HHLLQELRDDRKFHFVYGAAYRKGEELIVNPPRPKSDLNTLPSPHRFPDDLPDLGKRIVY 180 HLL+E+ K+H V+G AYRKG+++++NPPRPK LN LPSP+RF +D+ L KR+ Y Sbjct: 120 KHLLEEMNTTAKYHLVFGLAYRKGDDIVINPPRPKLPLNELPSPYRFSEDVASLSKRVTY 179 Query: 181 FETSRGCPFNCQFCLSSIEVGVRYYDIERVKADLLYLIENGAKVIKFLDRTFNINRNYAM 240 FETSRGCP++CQFCLSSIEVGVRY+D+ERVKADLLYLI +GAK+IKF+DRTFNI R+YA+ Sbjct: 180 FETSRGCPYSCQFCLSSIEVGVRYFDLERVKADLLYLINSGAKLIKFVDRTFNIRRDYAL 239 Query: 241 EMFQFLIDNHQGCVFQFEITADIMRPEVLDFLAEHAPPGIFRFEIGVQSTNDETNELVKR 300 E+F+FLI+NHQGCVFQFEITADIMRPEVL FL EHAP GIFRFEIGVQSTND TNELV+R Sbjct: 240 EVFRFLIENHQGCVFQFEITADIMRPEVLAFLNEHAPKGIFRFEIGVQSTNDLTNELVQR 299 Query: 301 RQNFTKLSRTVMKIKASGNIDQHLDLIAGLPQEDYATFRKTFNDVFAMEPEELQLGFLKM 360 RQNF KL RTV +K G IDQHLDLIAGLP+EDY +FRKTFNDVFAM PEELQLGFLKM Sbjct: 300 RQNFEKLKRTVTMVKEGGKIDQHLDLIAGLPEEDYQSFRKTFNDVFAMHPEELQLGFLKM 359 Query: 361 LRGTGLRAQAAKYNYTYMEHAPYEILSSHVMPFSDIIRLKRLEDVLEKYWTSHRLDHSVK 420 LRGTGLR +A +NY +M+ APYEIL ++V+ F +I+R+KR+EDVLEKYW +HR+D ++ Sbjct: 360 LRGTGLRLRAEDHNYLFMDQAPYEILGNNVLSFDEIVRIKRVEDVLEKYWNAHRMDTTIL 419 Query: 421 YLIRHVFQSPFDFFQEFGDYWEARGWQKIGHQLEDLFTRLHAFLTDRRTPSMPVITGLMK 480 YL+ + F SPFDFFQ FGDYW+ +GW +IGHQLEDLF RL AFL DRRT ++P+I GLM Sbjct: 420 YLVEYEFDSPFDFFQSFGDYWDEKGWARIGHQLEDLFIRLFAFLEDRRTDNLPIIKGLMM 479 Query: 481 LDYFLGHKYKPRKIWWDITLDKPEWSHYMKEIAEHPERLSAKLADAGFSERELQKFTVLE 540 DYF GHK+KPRK WW +L K + S +K +A PE S LA SE+EL K T+LE Sbjct: 480 YDYFRGHKHKPRKTWWPFSLTKEKQSSLIKRLAATPEVFSEALARHQLSEKELHKHTMLE 539 Query: 541 VLPFRL 546 V+PF L Sbjct: 540 VIPFSL 545 >C5D7G2.1 C5D7G2_9BACI Cobalamin B12-binding domain protein Length = 590 Score = 733 bits (1893), Expect = 0.0, Method: Compositional matrix adjust. Identities = 340/545 (62%), Positives = 429/545 (78%), Gaps = 2/545 (0%) Query: 1 MKIILATLNAKYIHTSLAIRLLKAYSEHEFQDIHLAEYTIKDPVMNIVSDLFQKKPDVIG 60 M II TLN+KYIHT+LAIR LKAY++ EF DI L EYTIKDP MNIV+DL+++KPD+IG Sbjct: 1 MNIICTTLNSKYIHTNLAIRYLKAYAQPEF-DIKLVEYTIKDPAMNIVTDLYRRKPDIIG 59 Query: 61 FSCYIWNIEETVKVIGILKQVMPEVTVVLGGPEVSYEPLYWMQREAGIDFVVNGDGEETF 120 FSCYIWNIEET+KV+ +LK++ P++T+V+GGPEVSY+ WM+ DF+V G+GEETF Sbjct: 60 FSCYIWNIEETIKVVKMLKKIAPDITIVVGGPEVSYDVREWMETVPEFDFIVIGEGEETF 119 Query: 121 HHLLQELRDDRKFHFVYGAAYRKGEELIVNPPRPKSDLNTLPSPHRFPDDLPDLGKRIVY 180 L E+ DR FH V+G A+R ++ +NP R K L +PSP RFP+D+P L KRI Y Sbjct: 120 KQFLMEMHGDRNFHNVHGLAFRHHGDIFINPQRNKIRLADMPSPFRFPEDIPHLPKRITY 179 Query: 181 FETSRGCPFNCQFCLSSIEVGVRYYDIERVKADLLYLIENGAKVIKFLDRTFNINRNYAM 240 ETSRGCPF+CQFCLSSIEVGVRY+D E++K D+ YL+++GA+ IKF+DRTFNI+R+YAM Sbjct: 180 IETSRGCPFSCQFCLSSIEVGVRYFDREKIKEDIRYLMKHGARTIKFVDRTFNISRSYAM 239 Query: 241 EMFQFLIDNH-QGCVFQFEITADIMRPEVLDFLAEHAPPGIFRFEIGVQSTNDETNELVK 299 +MFQFLID H G VFQFEITADIMRPEV++FL + APPG+FRFEIGVQSTNDE N LV Sbjct: 240 DMFQFLIDEHVPGTVFQFEITADIMRPEVIEFLNKEAPPGLFRFEIGVQSTNDEVNRLVM 299 Query: 300 RRQNFTKLSRTVMKIKASGNIDQHLDLIAGLPQEDYATFRKTFNDVFAMEPEELQLGFLK 359 R+QNF KL+RTVM +K G I QHLDLIAGLP+EDY +FRKTFNDVFA+ PEELQLGFLK Sbjct: 300 RKQNFEKLTRTVMMVKEGGKIAQHLDLIAGLPEEDYTSFRKTFNDVFALRPEELQLGFLK 359 Query: 360 MLRGTGLRAQAAKYNYTYMEHAPYEILSSHVMPFSDIIRLKRLEDVLEKYWTSHRLDHSV 419 MLRGTGLR +A Y Y +M+HAPYE+L ++V+ F DIIR+K++EDVLEKYW +HR+D ++ Sbjct: 360 MLRGTGLRLRAKDYGYVFMDHAPYEVLQNNVLSFDDIIRIKQVEDVLEKYWNAHRMDETI 419 Query: 420 KYLIRHVFQSPFDFFQEFGDYWEARGWQKIGHQLEDLFTRLHAFLTDRRTPSMPVITGLM 479 +YL+ +VF SPFDFFQEFG YW+ RGW KIGHQLEDLF RLH FL ++ +P+I LM Sbjct: 420 EYLVTNVFPSPFDFFQEFGTYWDERGWAKIGHQLEDLFRRLHEFLQTKKLDELPIIEALM 479 Query: 480 KLDYFLGHKYKPRKIWWDITLDKPEWSHYMKEIAEHPERLSAKLADAGFSERELQKFTVL 539 K DY K+KPRK WW+ DK S +++ EHPE+L + +E++L K TV+ Sbjct: 480 KYDYLRNQKHKPRKPWWEEKTDKSLRSSLYRQLLEHPEQLGNEFVSLELNEKKLFKHTVM 539 Query: 540 EVLPF 544 E++ F Sbjct: 540 EIIEF 544 >A4ILK5.1 A4ILK5_GEOTN Mg-protoporphyrin IX monomethyl ester oxidativecyclase Length = 597 Score = 723 bits (1866), Expect = 0.0, Method: Compositional matrix adjust. Identities = 341/544 (62%), Positives = 421/544 (77%), Gaps = 2/544 (0%) Query: 1 MKIILATLNAKYIHTSLAIRLLKAYSEHEFQDIHLAEYTIKDPVMNIVSDLFQKKPDVIG 60 M ++ TLNAKYIH +LAIR LKAY++ EF D+ L EYTIKDP MNIV+DL+Q++PDV+G Sbjct: 8 MNVVCTTLNAKYIHMNLAIRYLKAYAQPEF-DVKLVEYTIKDPAMNIVADLYQQQPDVVG 66 Query: 61 FSCYIWNIEETVKVIGILKQVMPEVTVVLGGPEVSYEPLYWMQREAGIDFVVNGDGEETF 120 FSCYIWNIEET+KV+ +LK+V P+VTVV+GGPEVSY+ WM+R DF+V G+GEETF Sbjct: 67 FSCYIWNIEETIKVVKMLKKVAPDVTVVVGGPEVSYDVREWMERVPEFDFIVIGEGEETF 126 Query: 121 HHLLQELRDDRKFHFVYGAAYRKGEELIVNPPRPKSDLNTLPSPHRFPDDLPDLGKRIVY 180 LL L D V G A+R G+ ++VNP R K L +PSP RFP+DLP L RIVY Sbjct: 127 KQLLFALNGDGNVSDVAGLAFRDGDRIVVNPQRNKIRLADMPSPFRFPEDLPHLPNRIVY 186 Query: 181 FETSRGCPFNCQFCLSSIEVGVRYYDIERVKADLLYLIENGAKVIKFLDRTFNINRNYAM 240 ETSRGCPF+CQFCLSSIEVGVRY+D E++K DL YL+++GA+ IKF+DRTFNI+R+YAM Sbjct: 187 VETSRGCPFSCQFCLSSIEVGVRYFDREKIKDDLRYLMQHGARTIKFVDRTFNISRSYAM 246 Query: 241 EMFQFLIDNH-QGCVFQFEITADIMRPEVLDFLAEHAPPGIFRFEIGVQSTNDETNELVK 299 +MF+FLID H G VFQFEITADIMRPEV++FL APPG+FRFEIGVQSTNDE N L+ Sbjct: 247 DMFRFLIDEHVPGTVFQFEITADIMRPEVIEFLNNEAPPGLFRFEIGVQSTNDEVNRLIM 306 Query: 300 RRQNFTKLSRTVMKIKASGNIDQHLDLIAGLPQEDYATFRKTFNDVFAMEPEELQLGFLK 359 R+QNF KLSRTV IK G I QHLDLIAGLP+EDY +FRKTFNDVFA+ PEELQLGFLK Sbjct: 307 RKQNFAKLSRTVTMIKEGGKITQHLDLIAGLPEEDYDSFRKTFNDVFALRPEELQLGFLK 366 Query: 360 MLRGTGLRAQAAKYNYTYMEHAPYEILSSHVMPFSDIIRLKRLEDVLEKYWTSHRLDHSV 419 +LRGTGLR +A +Y Y YM+HAPYE+L ++V+ F D+IR+K++EDVLEKYW +HR+D ++ Sbjct: 367 LLRGTGLRLRAHEYGYVYMDHAPYEVLRNNVLSFDDVIRIKQVEDVLEKYWNAHRMDETI 426 Query: 420 KYLIRHVFQSPFDFFQEFGDYWEARGWQKIGHQLEDLFTRLHAFLTDRRTPSMPVITGLM 479 +YL+ VF SPFDFFQ+FG YW+ RGW +IGHQLEDLF RL+ FL ++PV LM Sbjct: 427 EYLVTDVFPSPFDFFQQFGTYWDERGWARIGHQLEDLFRRLYEFLRTSVPDALPVAESLM 486 Query: 480 KLDYFLGHKYKPRKIWWDITLDKPEWSHYMKEIAEHPERLSAKLADAGFSERELQKFTVL 539 K DY KYKPRK WWD +K + + + E PE L A A G E+EL K TV+ Sbjct: 487 KYDYLRNQKYKPRKPWWDEKTEKTTRTAVYRTLLERPEVLGADFAALGLGEKELFKHTVV 546 Query: 540 EVLP 543 E++P Sbjct: 547 EIVP 550 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.323 0.140 0.424 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,682,377,522 Number of extensions: 156936395 Number of successful extensions: 351527 Number of sequences better than 1.0e-05: 589 Number of HSP's gapped: 350953 Number of HSP's successfully gapped: 592 Length of query: 649 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 507 Effective length of database: 1,722,912,073 Effective search space: 873516421011 Effective search space used: 873516421011 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.5 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (22.0 bits) S2: 135 (56.6 bits)