BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0217.0008.p (257 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3K3X9.1 B3K3X9_9BACI Beta-lactamase 197 8e-49 C4D7V3.1 C4D7V3_9SPHI Penicillin-binding protein, beta-lactamase... 164 8e-39 A9AUR5.1 A9AUR5_HERA2 Beta-lactamase 161 7e-38 B1ZWJ7.1 B1ZWJ7_OPITP Beta-lactamase 145 2e-33 C1TX04.1 C1TX04_9SPHI Penicillin-binding protein, beta-lactamase... 144 5e-33 >B3K3X9.1 B3K3X9_9BACI Beta-lactamase Length = 477 Score = 197 bits (501), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 100/245 (40%), Positives = 145/245 (59%), Gaps = 5/245 (2%) Query: 2 WNNRQLLPKEWVAAAASKQIDNNDGSPGASSSDWSKGYGYQFWRCRHNAYRGDGAFGQFC 61 W+ R+L+P+ W+ A SKQI N P S+SDW++GYGYQFW CR+ AYRGDGAFGQFC Sbjct: 227 WDGRRLIPEAWIEEATSKQISNG---PADSTSDWTEGYGYQFWMCRNGAYRGDGAFGQFC 283 Query: 62 IVMPEQDAVIAITSGGSDMQSILNGVWDILLPGMSMEPEAVESDPXXXXXXXXXXXXXSI 121 IV P+QDAV+AITSG DMQ++LN VW+ LLP M +P ++ + Sbjct: 284 IVFPQQDAVLAITSGLGDMQAVLNEVWEHLLPAMGADPLPADA--DAAASLAETLQALKL 341 Query: 122 QPVQLQKASTLEETLNGKVYRLKDHPQQLASLALSFTATEAVLTLQGRYGEQTVKLGRGE 181 P + S +E+ ++G VY L+++ ++L S ++ F VL L G +G ++ LGR E Sbjct: 342 DPPSEEALSPIEKDVSGIVYDLEENEEKLHSFSVRFEEDGGVLELTGEHGVNSIALGRSE 401 Query: 182 WAESSAKILDHKNNLIMSSFTWTDENKLKMTLLLVETPFCLTFEVSVREDSIVLKQQFNV 241 W + K++ + +S TW D+ L++ + L ETPF LT E + E+ I L N Sbjct: 402 WKSGTTKLIMMTDQAYAASMTWKDDRTLQLIVRLTETPFYLTTECTFSEEGIHLAYWMNQ 461 Query: 242 SMSAE 246 S + Sbjct: 462 SFEGK 466 >C4D7V3.1 C4D7V3_9SPHI Penicillin-binding protein, beta-lactamase class C Length = 530 Score = 164 bits (414), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 73/186 (39%), Positives = 113/186 (60%), Gaps = 2/186 (1%) Query: 1 VWNNRQLLPKEWVAAAASKQIDNNDGSPGASSSDWSKGYGYQFWRCRHNAYRGDGAFGQF 60 VWN ++L+ + W+A A SK++ + G AS +DW +GYGYQFWRCRH+AYRGDGAFGQ+ Sbjct: 261 VWNGKRLISEAWIADATSKEVQSKGGKGDASVNDWIQGYGYQFWRCRHDAYRGDGAFGQY 320 Query: 61 CIVMPEQDAVIAITSGGSDMQSILNGVWDILLPGMSMEPEAVESDPXXXXXXXXXXXXXS 120 CIV+P +DAVIAITS DMQ +LN +WD +LP +++ + + +D + Sbjct: 321 CIVLPNEDAVIAITSETGDMQGVLNAIWDHILP--ALQGKGLPADKIQQAALVQKLGSLT 378 Query: 121 IQPVQLQKASTLEETLNGKVYRLKDHPQQLASLALSFTATEAVLTLQGRYGEQTVKLGRG 180 + P Q +S++ +NGK + + D+ + ++L+F + L+ G+ V G G Sbjct: 379 LPPAASQTSSSVASQINGKTFAVADNASHVKDVSLTFGKDGCIFKLKDEQGDHQVLCGIG 438 Query: 181 EWAESS 186 W E + Sbjct: 439 RWREGT 444 >A9AUR5.1 A9AUR5_HERA2 Beta-lactamase Length = 486 Score = 161 bits (407), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 85/248 (34%), Positives = 131/248 (52%), Gaps = 13/248 (5%) Query: 2 WNNRQLLPKEWVAAAASKQIDNNDGSPGASSSDWSKGYGYQFWRCRHNAYRGDGAFGQFC 61 WN QLLP+ WV A++ QI N SDW++GYGYQFWRCRH AYRGDG FGQ+C Sbjct: 232 WNGIQLLPEAWVGQASAMQIING----ADPHSDWAQGYGYQFWRCRHGAYRGDGVFGQYC 287 Query: 62 IVMPEQDAVIAITSGGSD---MQSILNGVWDILLPGMSMEPEAVESDPXXXXXXXXXXXX 118 IVMPEQDAV+ IT GG D MQ LN VW+ LLP +M+ E + D Sbjct: 288 IVMPEQDAVLVIT-GGVDVFAMQQPLNLVWEYLLP--AMQAERLIDDTLAQRQLTEKLAN 344 Query: 119 XSIQPVQLQKASTLEETLNGKVYRLKDHPQQLASLALSFTATEAVLTLQGRYGEQTVKLG 178 + + + ++ + + ++G+ Y++ + + ++ F+AT + +Q +T+ G Sbjct: 345 LQVPTIHGESSAAIAQHVSGRSYQVDSNSFMIERISFDFSATGCSVVVQTATATETIVCG 404 Query: 179 RGEWAESSAKILDHK---NNLIMSSFTWTDENKLKMTLLLVETPFCLTFEVSVREDSIVL 235 W+ + + + +M+ WT ++ M + L +TPF T E + +++ Sbjct: 405 YRTWSLGRSSLFAQHFFDDTPVMAYGAWTAPDRFTMVVRLYQTPFVYTMEYHFVDAELLM 464 Query: 236 KQQFNVSM 243 Q NVS Sbjct: 465 TIQINVSF 472 >B1ZWJ7.1 B1ZWJ7_OPITP Beta-lactamase Length = 505 Score = 145 bits (367), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 79/253 (31%), Positives = 126/253 (49%), Gaps = 14/253 (5%) Query: 2 WNNRQLLPKEWVAAAASKQIDNNDGSPGASSSDWSKGYGYQFWRCRHNAYRGDGAFGQFC 61 WN +QL+P+ W+A A ++Q+ N G DW +GYGYQFWRCRH YRGDGAFGQFC Sbjct: 251 WNGKQLIPEAWIAEATARQMSNGSNPDG----DWDQGYGYQFWRCRHGFYRGDGAFGQFC 306 Query: 62 IVMPEQDAVIAITSGGSDMQSILNGVWDILLPGMSMEPEAVESDPXXXXXXXXXXXXXSI 121 IVMP+ DAV+AITSG DM ++N VWD ++PG ++ A+ +D SI Sbjct: 307 IVMPQYDAVVAITSGTRDMGLVMNLVWDHIVPG--LKDSALPADAAAEQSLKERLAHLSI 364 Query: 122 QPVQLQKASTLEETLNGKVYRLKDHPQQLASLALSFTATEAV--LTLQGRYGEQTVKLGR 179 + +S L ++ G+ + + + ++ + +T+ E+ + + Sbjct: 365 ATTKGAASSPLAASIAGRRFVFPANGAGIEAIQFEPAGADGTQPVTVWAGGEERQLVVAH 424 Query: 180 GEWAESSAKILDHKNN----LIMSSFTWTDENKLKMTLLLVETPFCLTFEVSVREDSIVL 235 G W + + D N L+ +S WT ++ ++ TP T+ D + + Sbjct: 425 GRW--NKGVMGDGGNQPGSELVAASGAWTADDTYTTQIVRYRTPLITTYRCRFAGDQVFM 482 Query: 236 KQQFNVSMSAEDL 248 + NV+ L Sbjct: 483 DAENNVAFGERKL 495 >C1TX04.1 C1TX04_9SPHI Penicillin-binding protein, beta-lactamase class C Length = 530 Score = 144 bits (364), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 82/247 (33%), Positives = 122/247 (49%), Gaps = 14/247 (5%) Query: 2 WNNRQLLPKEWVAAAASKQIDNNDGSPGASSSDWSKGYGYQFWRCRHNAYRGDGAFGQFC 61 +N +++LP WV A I + + DW +GYGYQFWRCR+ AYRGDGAFGQ+C Sbjct: 262 YNGKRILPAAWVEEATRSHIMSKGSNRKPEDDDWQQGYGYQFWRCRNGAYRGDGAFGQYC 321 Query: 62 IVMPEQDAVIAITSGGSDMQSILNGVWDILLPGMSMEPEAVESDPXXXXXXXXXXXXXSI 121 IVMP++D V+AITS SDMQ+ILN VW +LP +++ V +D ++ Sbjct: 322 IVMPKEDMVVAITSETSDMQAILNHVWAHILP--AVKATGVPADKDVQNQMQKKLTSLAL 379 Query: 122 QPVQLQKASTLEETLNGKVYRLKDHPQQLASLALSFTATEAVLTLQGRYGEQTVKLGRGE 181 + S L LNGK ++L D+ +++ +A F + L GE V G G Sbjct: 380 PLTPGKPTSELASKLNGKAFKLADNDLKISKVAFEFDKGWCLFRLTDAKGEHLVVNGLGN 439 Query: 182 W-------AESSAKIL-----DHKNNLIMSSFTWTDENKLKMTLLLVETPFCLTFEVSVR 229 W + K++ K I ++ W D+ +MT +ET T Sbjct: 440 WKIGLTDLSTMPLKLVLTPVPGEKKTKIAANGAWIDDATFEMTWRFIETAHYETVRCKFE 499 Query: 230 EDSIVLK 236 D++ L+ Sbjct: 500 GDNLQLE 506 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.315 0.130 0.387 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 1,427,777,759 Number of extensions: 52677159 Number of successful extensions: 121684 Number of sequences better than 1.0e-05: 42 Number of HSP's gapped: 121670 Number of HSP's successfully gapped: 42 Length of query: 257 Length of database: 3,060,696,203 Length adjustment: 133 Effective length of query: 124 Effective length of database: 1,807,701,208 Effective search space: 224154949792 Effective search space used: 224154949792 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 130 (54.7 bits)