BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0210.0008.p (575 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3K5A9.1 B3K5A9_9BACI Histidine kinase internal region 431 e-119 B8I4I2.1 B8I4I2_CLOCE Putative sensor with HAMP domain 425 e-117 B1D4M9.1 B1D4M9_9BACL Histidine kinase internal region 390 e-106 B9MQL3.1 B9MQL3_ANATD Putative sensor with HAMP domain 289 5e-76 A4XMX5.1 A4XMX5_CALS8 Integral membrane sensor signal transducti... 280 4e-73 >B3K5A9.1 B3K5A9_9BACI Histidine kinase internal region Length = 614 Score = 431 bits (1109), Expect = e-119, Method: Compositional matrix adjust. Identities = 234/562 (41%), Positives = 362/562 (64%), Gaps = 1/562 (0%) Query: 1 VLVPILSINALFYVQISRNVEARERENLEISVDRVVYDLMQIVNECVAISNTVAADRPYM 60 VL+PIL +N +F ++S + RE +NL+IS++R D+ ++ VA+S+ ++ D+ Sbjct: 28 VLLPILVVNLIFMDRMSELIREREEQNLDISMERARKDIHNFIDGGVAVSHALSTDKTLY 87 Query: 61 EMMDYAYPDNEAYYDAYNDSLKDKLRQYSNLHSYISWMGIYTSNPTIQNGNSYFILSDAD 120 EM+D Y +Y+ +++ L++++ Y +++ I + I+T N TI +G +Y +++D Sbjct: 88 EMLDREYESQLDFYETFDEQLRNRVTSYIPVNNQIQRISIFTENSTIVSGGNYHVINDNV 147 Query: 121 KRSEWYRKISSSTDKVLLTSYQGTNPLNPPQQEVLVSLIRKLDNF-TGQPYTKYLRIDLR 179 S+WY SSS VL+ +Y+ N +S+I K+D + T Y K LRID+ Sbjct: 148 LESDWYALWSSSAHPVLVAAYRAAEANNSASTVPYLSVIEKMDYYDTYDTYEKLLRIDID 207 Query: 180 LNNMQEVFQKERDYLDFKLLDEKNRVVLASDRSFSSLDASALLNVDTSLDQPPKQIVRAL 239 L+ + +V +ERDYLD L++E N +++++ + SA +D + V ++ Sbjct: 208 LSKIYDVIVRERDYLDMYLVNENNEIIMSASSGYERGKYSAYSKLDLEQYDEEDRHVFSI 267 Query: 240 SSAAYTTGWRLVGTPEGRKINHEMDRALRNSXXXXXXXXXXXXXXXXXXXRSYNLRVRLL 299 +A Y GW+L+G G +I M + RSYN RV+ L Sbjct: 268 GTARYVKGWKLIGINRGSRITSAMLDMQLFTVVLAAVVTLVAAVFITVMLRSYNYRVKRL 327 Query: 300 YKHMKLVKYEQFESIDMYEGKDEIGGLIRSFNLMTGKIRNLINDVYKLEIQKKDLELERV 359 +HM+ V E+F+ I++ EG+DEIGGLIR+FN MT K+ +LIN+VYKLEIQKK LE+ERV Sbjct: 328 ARHMQKVSNEKFDLIELDEGRDEIGGLIRNFNQMTAKMNSLINNVYKLEIQKKSLEMERV 387 Query: 360 RAELKYLESQVDPHFLFNTLNAILVICKKYKYEQVTDVIRNLALIMRRLLSWKDDLITLE 419 RAEL +L+SQ++PHFLFNTLNAILV+C K +Y VTD+I++L+ ++RRLLSW++DL+++E Sbjct: 388 RAELNFLQSQMNPHFLFNTLNAILVVCTKNRYTDVTDIIKSLSKLLRRLLSWREDLVSVE 447 Query: 420 EEVSFIEMYLQIEKFRFQNRFSYVLDIEPEVLNCRIPKMSIQALVENSCKHGLQSVKWAR 479 EE+ FIEMYL+IEKFRF+++F Y +I+ E L+ +IPKMSIQ LVEN+CK+GLQ++ A Sbjct: 448 EEIRFIEMYLKIEKFRFRDKFEYQFNIDMEALHYKIPKMSIQPLVENACKYGLQAMDGAG 507 Query: 480 EVHVSASRNGTGLLIMVTDNGKGIEKEKLEWIKSHLETEEDTGQNVGLRNVYKRLMLYYN 539 V +SAS L I++TD+GKGIE+ KL I + E+ +G + G+RNVY+RL LYY+ Sbjct: 508 LVTISASVARDYLRIVITDSGKGIEQSKLRDIILSVRNEQFSGNSFGIRNVYRRLELYYD 567 Query: 540 GKATFSIESTEYERTVITIQIP 561 F+I ST + T ++ +IP Sbjct: 568 DHVIFNIASTPNQGTTVSFEIP 589 >B8I4I2.1 B8I4I2_CLOCE Putative sensor with HAMP domain Length = 594 Score = 425 bits (1093), Expect = e-117, Method: Compositional matrix adjust. Identities = 223/565 (39%), Positives = 355/565 (62%), Gaps = 2/565 (0%) Query: 1 VLVPILSINALFYVQISRNVEARERENLEISVDRVVYDLMQIVNECVAISNTVAADRPYM 60 +L PI+ INA F + V RE N +IS+ R D+ ++ +A+S++++ D Sbjct: 28 ILTPIIIINAAFLDKFYTVVTQREENNYQISMQRAKNDINALIEGGIAVSHSISTDAIIY 87 Query: 61 EMMDYAYPDNEAYYDAYNDSLKDKLRQYSNLHSYISWMGIYTSNPTIQNGNSYFILSDAD 120 ++MD Y D YYD Y+ +L+++L Y+ ++YI+ +G+Y NP+I+ GN+Y+ + + Sbjct: 88 DLMDARYEDAGEYYDIYSSTLRNRLSIYTVAYNYITNIGLYVDNPSIRAGNTYYYIDRSV 147 Query: 121 KRSEWYRKISSSTDKVLLTSYQGTNPLNPPQQEVLVSLIRKL-DNFTGQPYTKYLRIDLR 179 + + WY+ +S S ++VL+ +Y G++ P ++ +S++R +N + K L++D+ Sbjct: 148 RNTIWYKDLSESNEQVLIRTYMGSSNSVPIRRIQYLSILRSSKNNPSLGSREKILKVDIS 207 Query: 180 LNNMQEVFQKERDYLDFKLLDEKNRVVLASDRSFSSLDASALLNVDTSLDQPPKQIVRA- 238 L + +F +ERDYL L+D +N +V ++ + + L +++ I+ A Sbjct: 208 LEKVFTIFNRERDYLSLYLIDPQNTIVCSTTGRYGLNNIDKLEKLNSESLGKENMILEAY 267 Query: 239 LSSAAYTTGWRLVGTPEGRKINHEMDRALRNSXXXXXXXXXXXXXXXXXXXRSYNLRVRL 298 L +++Y GW+L+G + +I+ + LR RSYN R+R Sbjct: 268 LGNSSYFKGWKLIGVTDRERISDSVGDTLRFVLIFAFISVLISSLLMYIIVRSYNYRLRK 327 Query: 299 LYKHMKLVKYEQFESIDMYEGKDEIGGLIRSFNLMTGKIRNLINDVYKLEIQKKDLELER 358 L KHM K +FE I++ EG+DEIGG+IR+FNLM +I LINDVYKLE+QKK LELER Sbjct: 328 LSKHMLKFKDGKFELININEGEDEIGGVIRNFNLMAARINTLINDVYKLELQKKSLELER 387 Query: 359 VRAELKYLESQVDPHFLFNTLNAILVICKKYKYEQVTDVIRNLALIMRRLLSWKDDLITL 418 VRAE+ +L+SQ++PHFLFNTLNAILV+ K Y ++ DVI+ L+ +RRLLSWKDDL+T+ Sbjct: 388 VRAEINFLQSQMNPHFLFNTLNAILVVSVKNNYTEIVDVIKYLSKTLRRLLSWKDDLVTI 447 Query: 419 EEEVSFIEMYLQIEKFRFQNRFSYVLDIEPEVLNCRIPKMSIQALVENSCKHGLQSVKWA 478 EEE+SF EMYL+IEKFRF ++F Y +++ +L+ +IPKMS+Q LVEN+CKHG+Q++K Sbjct: 448 EEELSFTEMYLKIEKFRFCDKFHYNINVNETLLDYQIPKMSLQPLVENACKHGIQTIKEV 507 Query: 479 REVHVSASRNGTGLLIMVTDNGKGIEKEKLEWIKSHLETEEDTGQNVGLRNVYKRLMLYY 538 ++++ +GL + V DNG GI++ L I ++++E + ++G+RNVY+RL LYY Sbjct: 508 GVININIDMCESGLRVSVKDNGSGIDQYTLSGIIDNVKSEVEQSTSIGIRNVYRRLRLYY 567 Query: 539 NGKATFSIESTEYERTVITIQIPGE 563 +F+IES T I IP E Sbjct: 568 GENISFNIESCINTGTTIYFTIPFE 592 >B1D4M9.1 B1D4M9_9BACL Histidine kinase internal region Length = 598 Score = 390 bits (1003), Expect = e-106, Method: Compositional matrix adjust. Identities = 222/569 (39%), Positives = 341/569 (59%), Gaps = 19/569 (3%) Query: 1 VLVPILSINALFYVQISRNVEARERENLEISVDRVVYDLMQIVNECVAISNTVAADRPYM 60 +L+PI+ IN FY Q S N+ RE+ENL S+DR +L +++E VA+S+++ D Sbjct: 26 ILIPIIGINVFFYQQNSDNIRIREQENLRKSMDRAAAELHSMIDESVAVSHSIEGDDTLN 85 Query: 61 EMMDYAYPDNEAYYDAYNDSLKDKLRQYSNLHSYISWMGIYTSNPTIQNGNSYFILSDAD 120 E +D Y + Y++Y+ L++KL++Y ++ I + IYT N TIQ GN+Y++++ + Sbjct: 86 EALDKTYDSPVSSYESYDSVLRNKLKRYMPVYPNILEIRIYTYNHTIQTGNNYYVINAPE 145 Query: 121 KRSEWY----RKISSSTDKVLLTSYQGTNPLNPPQQEVLVSLIRKLD---NFTGQPYTKY 173 ++S W R+ + + + GT Q +S+I +D + Y K+ Sbjct: 146 EKSPWLGPLLRQPGHAFRVIAYSEVSGTT-----GQTKKISVISDMDQGFSIVKPQYRKF 200 Query: 174 LRIDLRLNNMQEVFQKERDYLDFKLLDEKNRVVL-ASDRSFSSLDASALLNVDTSLDQPP 232 LRIDL ++ + ++ +E D L +L++E+N++V R S DA D S Sbjct: 201 LRIDLNVDKIYDILSRESDSLQLELVNEQNQIVAETGGRGKSVYDA------DMSDWGKG 254 Query: 233 KQIVRALSSAAYTTGWRLVGTPEGRKINHEMDRALRNSXXXXXXXXXXXXXXXXXXXRSY 292 V L + +Y GW+L+G +I +D A R+ RSY Sbjct: 255 DVFVSNLGTVSYVQGWKLIGRANNDRITTLLDEARRSILWLAVISTLIPSLLIFVMLRSY 314 Query: 293 NLRVRLLYKHMKLVKYEQFESIDMYEGKDEIGGLIRSFNLMTGKIRNLINDVYKLEIQKK 352 + R++ L +HM V+ E+F+ + + EGKDEIGGLI ++N+MT KI LINDVYKLEI +K Sbjct: 315 HYRIKKLARHMDRVRNERFDQVTLPEGKDEIGGLINTYNMMTRKINTLINDVYKLEIHQK 374 Query: 353 DLELERVRAELKYLESQVDPHFLFNTLNAILVICKKYKYEQVTDVIRNLALIMRRLLSWK 412 LE+ERVR E+ L+SQ++PHFLFNTLNA+LV+ K Y+ VT++I++L+L++RRLL Sbjct: 375 SLEVERVRMEMNMLQSQMNPHFLFNTLNALLVVATKNGYKDVTEIIKSLSLLLRRLLRRA 434 Query: 413 DDLITLEEEVSFIEMYLQIEKFRFQNRFSYVLDIEPEVLNCRIPKMSIQALVENSCKHGL 472 DDL+ L+EE+ F MYLQIEKFRF +RF YV+DI+P + R+P MSIQ L EN+CKHGL Sbjct: 435 DDLVPLKEELQFTLMYLQIEKFRFGDRFDYVVDIDPLANDVRVPIMSIQPLAENACKHGL 494 Query: 473 QSVKWAREVHVSASRNGTGLLIMVTDNGKGIEKEKLEWIKSHLETEEDTGQNVGLRNVYK 532 Q++K V + A + GL + V DNG G+E+E L+ I+ + +E+ +VGLRNVY+ Sbjct: 495 QAIKGGGAVRIEARMSERGLTVSVADNGIGMEQEALDRIQQAVRSEQAMEGHVGLRNVYR 554 Query: 533 RLMLYYNGKATFSIESTEYERTVITIQIP 561 RL L+Y+ F + + ++ QIP Sbjct: 555 RLELFYHESVQFRMMNGPEGGLTVSYQIP 583 >B9MQL3.1 B9MQL3_ANATD Putative sensor with HAMP domain Length = 610 Score = 289 bits (740), Expect = 5e-76, Method: Compositional matrix adjust. Identities = 189/575 (32%), Positives = 323/575 (56%), Gaps = 19/575 (3%) Query: 1 VLVPILSINALFYVQISRNVEARERENLEISVDRVVYDLMQIVNECVAISNTVAADRPYM 60 VL+P L + +F + I +N++ ++ ++ + + + ++ ++++E + SNT+ D Sbjct: 39 VLIPTLVSHFIFTIFIIKNLQQQKITQIKSAFNILNTNIKKVIDEAILYSNTLYTDDLLN 98 Query: 61 EMMDYAYPDNEAYYDAYNDSLKDKLRQYSNLHSYISWMGIYTSNPTIQNGNSYFILSDAD 120 +M+D Y + +Y Y L++++ Q N++S I+ + IYT+NPTI N + Y L+ + Sbjct: 99 DMLDINYHGMDDFYSNYVQYLRNRIYQGRNVYSNIARVTIYTNNPTILNSDGYRKLNIQE 158 Query: 121 KRSEWYRKISSSTDKVLL--TSYQGTNPLNPPQQEVLVSLIRKLDNF------TGQ--PY 170 + EWY K+ ++ +++ TS G N +E VSLIR L+ + TG Y Sbjct: 159 VK-EWYDKVINNLQGIVIIPTSDDGVNG-----EEGYVSLIRNLNQYEQRSTSTGNNSKY 212 Query: 171 TKYLRIDLRLNNMQEVFQKERDYLDFKLLDEKNRVVLASDRSFSSLDASALLNVDTSLDQ 230 TK +ID+ L++ E + L+D NR++ A + + + + +TS Sbjct: 213 TKIAKIDIYLSSFFNSINFEVFGGEIYLIDSSNRIIAAHTYN-NLIFTKPFVKFETSKFV 271 Query: 231 PPKQIVRALS-SAAYTTGWRLVGTPEGRKINHEMDRALRNSXXXXXXXXXXXXXXXXXXX 289 P V + GW+LVG + E+ RA+ Sbjct: 272 PKGSYVFVNNLDINLLNGWKLVGVFSRSYMMGEIYRAIEFILLISLLSLIFATFLIRLIT 331 Query: 290 RSYNLRVRLLYKHMKLVKYEQFESIDMYEGKDEIGGLIRSFNLMTGKIRNLINDVYKLEI 349 S + R+ LL +HM+ VK ++FE + EG DEIG LIR FN MT +++ LI EI Sbjct: 332 SSISNRLELLERHMRKVKKQRFEILTCREGNDEIGNLIREFNNMTIRLKELIEKEMLSEI 391 Query: 350 QKKDLELERVRAELKYLESQVDPHFLFNTLNAILVICKKYKYEQVTDVIRNLALIMRRLL 409 QKK LE+E+ +AE+ L+SQ++PHFLFNTL++I + + ++I+ L +RRL+ Sbjct: 392 QKKTLEVEKKQAEINALQSQINPHFLFNTLDSIRMRSVLKNELETAEIIKYLTRTLRRLI 451 Query: 410 SWKDDLITLEEEVSFIEMYLQIEKFRFQNRFSYVLDIEPEVLNCRIPKMSIQALVENSCK 469 W +D+ T++EE++F+E +L+I+++RF + +Y + +E + NC IPKM+IQ LVEN+C Sbjct: 452 YWGNDITTVQEEINFVEDFLKIQQYRFGEKLTYEIFVEEDAKNCLIPKMTIQPLVENACI 511 Query: 470 HGLQSVKWAREVHVSASRNGTGLLIMVTDNGKGIEKEKLEWIKSHLETEEDTGQNVGLRN 529 HG++ + + +V V + G L+I V DNG G+ ++KLE + ++L +++GL+N Sbjct: 512 HGIEEKEDSGKVIVKVKKEGINLIIEVADNGIGMNEKKLEELYANLNNPL-YDKSIGLKN 570 Query: 530 VYKRLMLYYNGKATFSIESTEYERTVITIQIPGEL 564 VY+RLMLYYN A F IES+ + T + I++P EL Sbjct: 571 VYRRLMLYYNDNAEFYIESSINKGTKVVIKLPLEL 605 >A4XMX5.1 A4XMX5_CALS8 Integral membrane sensor signal transduction histidine kinase Length = 613 Score = 280 bits (715), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 181/581 (31%), Positives = 312/581 (53%), Gaps = 31/581 (5%) Query: 1 VLVPILSINALFYVQISRNVEARERENLEISVDRVVYDLMQIVNECVAISNTVAADRPYM 60 VL+P + + +F + I +N++ ++ + ++ + + ++ +++ E + SNT+ D Sbjct: 40 VLIPTIVTHFIFTLFIVKNLQQQKIDQIKGVFNILNANIKKVLEEAILYSNTLYTDELLN 99 Query: 61 EMMDYAYPDNEAYYDAYNDSLKDKLRQYSNLHSYISWMGIYTSNPTIQNGNSYFILSDAD 120 +M+D Y E +Y Y L++++ Q N++S I+ + IYT+NPTI + + Y +D + Sbjct: 100 DMLDIGYRGLEDFYSNYEGYLRNRIYQGRNVYSNIARVTIYTNNPTIVDSDGYRKFNDGE 159 Query: 121 KRSEWYRKISSSTDKVLL--TSYQGTNPLNPPQQEVLVSLIRKLDNF--------TGQPY 170 + EW+ + + +++ T +G N +E VSL R L+ F Y Sbjct: 160 AK-EWFSLVMDNQQGIIVIPTVDEGVNG-----EEGYVSLFRNLNQFERRSTSRGNNSKY 213 Query: 171 TKYLRIDLRLNNMQEVFQKERDYLDFKLLDEKNRVVLASD-------RSFSSLDASALLN 223 K +ID+ L++ E + LLD+ NR++ A + F D ++ Sbjct: 214 LKIAKIDMYLSSFFNSINFEIFGGEIYLLDKSNRIIAARSNNSVIFAKPFIKFDKRKFVS 273 Query: 224 VDTSLDQPPKQIVRALSSAAYTTGWRLVGTPEGRKINHEMDRALRNSXXXXXXXXXXXXX 283 D+ + + K LSS W+LVG + E+ RA+ Sbjct: 274 KDSYIFEE-KLDYNLLSS------WKLVGVFSKSYMLREIYRAIEYILFISVLSLLFATL 326 Query: 284 XXXXXXRSYNLRVRLLYKHMKLVKYEQFESIDMYEGKDEIGGLIRSFNLMTGKIRNLIND 343 S + R+ LL +H+K ++ + FE ++ EG DEIG +I+ FN MT K++ LI Sbjct: 327 LIRMITSSLSARLELLTRHIKKIRKQNFEILNCKEGNDEIGNVIKEFNNMTIKLKELIEK 386 Query: 344 VYKLEIQKKDLELERVRAELKYLESQVDPHFLFNTLNAILVICKKYKYEQVTDVIRNLAL 403 EIQ+K LE+E+ +AEL L+SQ++PHFLFNTL++I + + ++I+ L Sbjct: 387 EMLSEIQRKTLEIEKKQAELNALQSQINPHFLFNTLDSIRMRSVLKNELETAEIIKYLTR 446 Query: 404 IMRRLLSWKDDLITLEEEVSFIEMYLQIEKFRFQNRFSYVLDIEPEVLNCRIPKMSIQAL 463 +RRL+ W +D+ T+EEE+ F+E +L+I+K+R + +Y + ++ NC IPKM+IQ L Sbjct: 447 TLRRLIYWGNDITTVEEEIGFVEDFLKIQKYRLGEKLAYRIYVDEVARNCLIPKMTIQPL 506 Query: 464 VENSCKHGLQSVKWAREVHVSASRNGTGLLIMVTDNGKGIEKEKLEWIKSHLETEEDTGQ 523 VEN+C HG++ ++ E+ + + L+I V DNG G+++EKL + +L + + Sbjct: 507 VENACIHGIEEIEGNGEIIIEVKKEEAYLIIKVEDNGIGMDEEKLSQLYENL-SNNTYEK 565 Query: 524 NVGLRNVYKRLMLYYNGKATFSIESTEYERTVITIQIPGEL 564 N+GL+NVYKRLMLYYN F I S + T + I+IP EL Sbjct: 566 NIGLKNVYKRLMLYYNNAVDFKIHSNFKQGTRVVIKIPLEL 606 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.318 0.135 0.382 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,200,732,262 Number of extensions: 129844584 Number of successful extensions: 427201 Number of sequences better than 1.0e-05: 2108 Number of HSP's gapped: 424158 Number of HSP's successfully gapped: 2110 Length of query: 575 Length of database: 3,060,696,203 Length adjustment: 141 Effective length of query: 434 Effective length of database: 1,732,333,088 Effective search space: 751832560192 Effective search space used: 751832560192 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 134 (56.2 bits)