BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0183.0008.p (615 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B8I996.1 B8I996_CLOCE Putative sensor with HAMP domain 243 6e-62 B1DAS7.1 B1DAS7_9BACL Integral membrane sensor signal transducti... 237 3e-60 B1DFV6.1 B1DFV6_9BACL Histidine kinase internal region 233 4e-59 A4XMF9.1 A4XMF9_CALS8 Integral membrane sensor signal transducti... 214 2e-53 Q8R7Q4.1 Q8R7Q4_THETN Predicted ATPase 211 2e-52 >B8I996.1 B8I996_CLOCE Putative sensor with HAMP domain Length = 603 Score = 243 bits (619), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 165/592 (27%), Positives = 308/592 (52%), Gaps = 19/592 (3%) Query: 24 QNMPLRRKILISNILIVLLALMIFVLSIHRIVFNQTLGRTSASSQQEVKLVSQSMKTVFQ 83 N+ ++ KI I I+L +L IF + I + + + ++++E+ L+ +S+ + Sbjct: 15 NNISIKSKIFIFYAGILLASLSIFAILTINISNQAIVEKVTKNAERELSLIDKSLLNLAN 74 Query: 84 SVQNFSKFALINQDTQNVLSRDTGADGDVSPLKSIHNTLAAMLET--EPNIDSVIIESIG 141 + +N+++ ++ QN L R + D + TL+ ++ +PN + + SI Sbjct: 75 NSENYARILSMDNRMQNQLERIENNELDSIDNIEVEKTLSTVISNVVQPNTN-IAAASIM 133 Query: 142 GDLYYTSNLTGVTPQSLAIY-PKDKIDAAKGGAV--WVDTLKPSFLSGMTAKNMISVCRV 198 Y ++ + S++ Y +D I++ V W K + G +++ ++ + Sbjct: 134 SSKYMFFDVGYIDNSSISRYFNRDLINSITKNKVPTWTRLFKVRYKFG-GDEDVFAIAKT 192 Query: 199 IMSMEKGTPIGYIYVNIDERTLARLYHNEQDNQNPT--LVVNQEGVVISAYEAALVSRTV 256 I+ M+ G +G + + E+ +A +Y N N+N +V NQ+ ++ + ++ L + Sbjct: 193 IIGMDTGHVLGTAVLYLKEKDVAAIYLNNIVNENDKFYIVDNQKNIISTQDKSELYRKFD 252 Query: 257 EDHSLARWVKSASGGSRT--ERVGDKPYLVSLQRLDPYGWKVIHLVPTSELTNGYWKIAL 314 E+ L ++ +++ +GDK L+++Q D WKV+ ++P E+T K+ Sbjct: 253 EELYLGKYKLEDISDTKSLIRNIGDKKVLITVQNFDKLDWKVVSVIPLDEITYENKKMTQ 312 Query: 315 SIAVFGLISMLSAMVLSFVFARRLTRPLSELSEVIVEVGAGNFERRASAGSQDEVGRLGA 374 I +FG+ ++ A V S++ + +++P+ +L ++ E+ +GN + RA + E+G LG Sbjct: 313 LILIFGVTCLICAFVASYLLSYTISKPILKLVNIMKEIKSGNLKLRADLNVKGEIGMLGD 372 Query: 375 TFNEMVEHIQDLMLTIXXXXXXXXXXXXXXXYSQIKPHFLYNTLDTIRAMAVMTNAKEIS 434 FN +++ I L+ I SQIKPHFLYNT++TI + + Sbjct: 373 GFNSLMDKINVLVEHIYTEQRLKRENEFKLLQSQIKPHFLYNTIETIISFIKLNLKDNAM 432 Query: 435 SILKALGEFYRISLSNGQELIAAAQEKRHLESYLYIQQIRF-KKLNYRISFEPGIESCQV 493 K L FYRISLS G ++I E +++YL IQ++R+ + L+YR+ FE I Q+ Sbjct: 433 LTAKYLAGFYRISLSKGNDIITIRDEMNLIDNYLSIQKMRYVEYLDYRLEFEEEILKYQI 492 Query: 494 PTMLLQPLVENAIHHGIRGMPDGGLCEITGSMERSGEERILCFIVRDNGKGMSEEEQRQI 553 P + LQPLVEN+I+HG++ D G+ I G E +GE +I F D+G GMSEE ++ Sbjct: 493 PKLTLQPLVENSIYHGLKQKEDRGILIIKGEFE-NGEIKIEVF---DDGVGMSEENINRV 548 Query: 554 WLSSSEEGEYS--FGLKNIQDRIQLRFGEAYGIVLSSEPGHGVEVKVRLPLI 603 L+ G+ S FG+ ++ R++L +G+ YG+ + S+ V +RLP I Sbjct: 549 -LNRLINGQKSNDFGIYSVNSRLKLLYGDEYGLSIESKESEFTRVTLRLPAI 599 >B1DAS7.1 B1DAS7_9BACL Integral membrane sensor signal transduction histidine kinase Length = 598 Score = 237 bits (604), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 163/605 (26%), Positives = 306/605 (50%), Gaps = 40/605 (6%) Query: 22 YRQNMPLRRKILISNILIVLLALMIFVLSIHRIVFNQTLGRTSASSQQEVKLVSQSMKTV 81 Y + ++ KI ISNILI+++ + + + I + + + +S +E+ L+ +++T+ Sbjct: 7 YIGGISIKNKIFISNILIIVVFISTQSIFANTISQKAIIDKATNNSSRELVLIKNNLQTL 66 Query: 82 FQSVQNFSKFALINQDTQNVLSRDTGADGD---VSPLKSIHN---------TLAAMLETE 129 S++++SK + QN L D + + + P++ ++N T++ ++E Sbjct: 67 LSSIEDYSKILASDYRLQNALYYDYLLNNEPNAIKPVEGLNNLSMNKTLSETISNIVEPN 126 Query: 130 PNIDSVIIES-------IG-GDLYYTSNLTGVTPQSLAIYPKDKIDAAKGGAVWVDTLKP 181 I +V I + +G D Y + L G + D +W +K Sbjct: 127 TKIKAVSILTSNQHWVDVGFADNAYAARLFGYGYGA---------DDRTYLPIWTGLIKF 177 Query: 182 SFLSGMTAKNMISVCRVIMSMEKGTPIGYIYVNIDERTLARLYHNEQDNQNPTLVVNQEG 241 FL N+ +V + ++ + G IG I++ + E T+A +Y + +V+ +G Sbjct: 178 RFLY-EGDDNVFAVSKTVIHKDTGKTIGRIFLYVKETTIASIYEEGKKKGGEFYIVDADG 236 Query: 242 VVISAYEAALVSRTVEDHSLARWVKSASGGSRTERVGDKPYLVSLQRLDPYGWKVIHLVP 301 +ISA A++ R ++ + S T+ G + L+ R +P W ++ + Sbjct: 237 RIISAQNKAMLYRDFKEAASISIPDDGKDASFTQGSGSEEMLILTHRFEPLQWTIVSAIA 296 Query: 302 TSELTNGYWKIALSIAVFGLISMLSAMVLSFVFARRLTRPLSELSEVIVEVGAGNFERRA 361 +E+T+ +I I G +L A+++SF +R +T P+ L++ + E+ G + R+ Sbjct: 297 MNEITSERKEINQLIIGIGAACLLLALMVSFQLSRSITSPIFRLAKTMREIRTGKMQVRS 356 Query: 362 SAGSQDEVGRLGATFNEMVEHIQDLMLTIXXXXXXXXXXXXXXXYSQIKPHFLYNTLDTI 421 S S DE+G L FN +++ I+ LM SQ+KPHFLYNT++TI Sbjct: 357 SYQSTDEIGYLSEGFNNLMDRIEALMAENVEKQRTKAEIEFKLLQSQVKPHFLYNTVETI 416 Query: 422 RAMAVMTNAKEISSILKALGEFYRISLSNGQELIAAAQEKRHLESYLYIQQIRF-KKLNY 480 ++ + K+ + + + FY+ISLS G ++I+ +E R ESYL IQQ+R+ + + Y Sbjct: 417 ISLIKLGLGKQAITAAQYMANFYKISLSKGNDIISVGEEMRLTESYLEIQQLRYVEYMAY 476 Query: 481 RISFEPGIESCQVPTMLLQPLVENAIHHGIRGMPDGGLCEITGSMERSGEERILCFIVRD 540 + + I + +P + LQP+VENAI+HG++ + G+ ITG RSG + + D Sbjct: 477 TMDIDDDILTYSIPKLTLQPIVENAIYHGLKLKQEKGIVRITG--RRSGNH--IEIEIYD 532 Query: 541 NGKGMSEEEQRQIWLSS---SEEGEYSFGLKNIQDRIQLRFGEAYGIVLSSEPGHGVEVK 597 NG GM +++ + I S SE G FG++++ +RI++ +G+ YG+ + SE G ++ Sbjct: 533 NGAGMHKDQAKAIMAESGVPSESG--GFGIRSVSNRIRMLYGDRYGLQVESESGVYTKII 590 Query: 598 VRLPL 602 + LPL Sbjct: 591 IVLPL 595 >B1DFV6.1 B1DFV6_9BACL Histidine kinase internal region Length = 599 Score = 233 bits (595), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 170/596 (28%), Positives = 292/596 (48%), Gaps = 28/596 (4%) Query: 22 YRQNMPLRRKILISNILIVLLALMIFVLSIHRIVFNQTLGRTSASSQQEVKLVSQSMKTV 81 YR NM +R+KI I I IV+L L++ V + + I + TL +T + + E ++S M + Sbjct: 8 YR-NMYIRKKITIVFIPIVVLPLLVIVFTSNSIFSDSTLQKTKVNIKGETSVISARMDNI 66 Query: 82 FQSVQNFSKFAL--INQDTQNVLSRDTGADGDVSPLKSIHNTLAAMLETEPNIDSVIIES 139 + + + S + IN+ Q++ + +V I N L +I+S+ Sbjct: 67 YSNGETCSSILVKDINRIYQDLGIGEQNTYQNVRFQNQILNEFDFNLRAFKDIESIAYMD 126 Query: 140 IGGDLYYTS-NLTGVTPQSLAIYPKDKIDAAK-GGAVWVDTLKPSFLSGMTAKNMISVCR 197 +LY + L +++ + + A +VW +L+ ++++ + Sbjct: 127 SMNNLYVSDYRLNANMDKAMRSRMLESLKAPGIPTSVWFPMQTRDYLTTDPNSPVLTIGK 186 Query: 198 VIMSMEKGTPIGYIYVNIDERTLARLYHNE----QDNQNPTLVVNQEGVVISAYEAALVS 253 ++ +E G +G I +NI E T + ++ E +D N +V+ G V+S+ + + Sbjct: 187 RVVDIESGETLGIIILNIRESTFSSIFPMEGIKGEDGFN---IVDANGRVVSSTDKDALL 243 Query: 254 RTVEDHSLARWVKSASGG-SRTERVGDKPYLVSLQRLDPYGWKVIHLVPTSELTNGYWKI 312 + V + +L W+++ + G S+ +G+ YL+ + + GW + + ELT + Sbjct: 244 QPVPNANLLNWLQTGNDGESKYVHLGNGDYLIVKKEIPELGWTLYKQMMVKELTIDTYTN 303 Query: 313 ALSIAVFGLISMLSAMVLSFVFARRLTRPLSELSEVIVEVGAGNFERRASAGSQDEVGRL 372 + +I V GL+ + A++ S V +R + +P+ +L+ V V GN + SQDEVG L Sbjct: 304 SFTIFVVGLLCTIIAIISSIVLSRHIAKPIIKLTRVAKLVREGNLNTASEVKSQDEVGIL 363 Query: 373 GATFNEMVEHIQDLMLTIXXXXXXXXXXXXXXXYSQIKPHFLYNTLDTIRAMAVMTNAKE 432 TFNEM+ I L+ + +QIKPHF YNTLD I + Sbjct: 364 AGTFNEMIVTINGLLNKVTQEQRKKREYEFALIQAQIKPHFFYNTLDLIYVLCEKGKTSL 423 Query: 433 ISSILKALGEFYRISLSNGQELIAAAQEKRHLESYLYIQQIRFKK-LNYRISFEPGIESC 491 + AL +FYRISLS G+E+I A+E + E YL+IQ+ R+ +++ I +P I Sbjct: 424 AADTTMALADFYRISLSKGKEIITIAEELKVAEDYLFIQKTRYSDIIDFTIDVDPAILEY 483 Query: 492 QVPTMLLQPLVENAIHHGIRGMPDGGLCEITGSMERSGEERILCFIVRDNGKGMSEEEQR 551 + + +QPL+ENAI+HG+R G I G +R G + V D+G G EE Sbjct: 484 TIIKLTIQPLIENAIYHGLRPKMTPGKITIKGFWDRQG----IILQVIDDGIGFPTEE-- 537 Query: 552 QIWLSSSEEGEY------SFGLKNIQDRIQLRFGEAYGIVLSSEPGHGVEVKVRLP 601 W ++ + SFGLK++ +RIQL FGE YGI + S G +V + +P Sbjct: 538 --WQANIDPAAQPIPAGKSFGLKSVHERIQLYFGERYGIQVESGMSRGTKVTITIP 591 >A4XMF9.1 A4XMF9_CALS8 Integral membrane sensor signal transduction histidine kinase Length = 596 Score = 214 bits (546), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 164/601 (27%), Positives = 288/601 (47%), Gaps = 39/601 (6%) Query: 22 YRQNMPLRRKILISNILIVLLALMIFVLSIHRIVFNQTLGRTSASSQQEVKLVSQSMKTV 81 Y + ++ KILI I+++ ++ L + I NQ ++ K ++ S+ + Sbjct: 8 YFLRLSIKYKILILFYSIIVITSLVLALFSYTISTNQLKEEVGNLLLRDTKRIAASIDFL 67 Query: 82 FQSVQNFSKFALINQDTQNVLS-RDTGADGDVSPLKSIHNTLAAMLETEPNIDSVIIESI 140 + V S F ++Q QN ++ R + PL A++L ++ I +++ S Sbjct: 68 QKDVNELSSFLFLDQRIQNFINPRPDFTKYSLEPL-------ASLLASKDYISFIMLYSF 120 Query: 141 GGDLYYTSN--LTGVTP----QSLAIYPKDKIDAAKGGAVWVDTLKPSFLSGMTAKN--- 191 GD YY SN TGV +S + +I KG +WV F + AKN Sbjct: 121 QGDKYYFSNDNSTGVADFYELKSTDFF--KQIIKNKGAPMWVSLNSLPF--SLIAKNNYP 176 Query: 192 MISVCRVIMSMEKGTPIGYIYVNIDERTLARLYHNEQDNQNPTLVVNQEGVVISAYEAAL 251 I++ R+++ P G + + I+ T+ ++Y + + + I ++E+ Sbjct: 177 KIAMARLLLDFNTYEPAGVLIICINIPTIEKIYMEDLKEKEACFFIADSSNRIISFESTT 236 Query: 252 VSRTVEDHSLARWVKSASGGSRTERV---GDKPYLVSLQRLDPYGWKVIHLVPTSELTNG 308 T + A+ + + + SR + L++ + W+++ +V N Sbjct: 237 PQFTA---TFAQKLLNKNILSRENEIITANSSKLLITSSYIPTSNWRLVSVVSLENAINA 293 Query: 309 YWK--IALSIAVFGLISMLSAMVLSFVFARRLTRPLSELSEVIVEVGAGNFERRASAG-- 364 + L I V ++ ++ A V+S F+ LT PL +L + +V GNF + + Sbjct: 294 IRNSFVLLYIRVL-ILCLIFAFVISMYFSSMLTAPLQKLVSSMKKVRQGNFREQVNIDPH 352 Query: 365 SQDEVGRLGATFNEMVEHIQDLMLTIXXXXXXXXXXXXXXXYSQIKPHFLYNTLDTIRAM 424 + DE+ + + +N MVE I +L+ + +QI PHFLYNTLDTI Sbjct: 353 ASDEIAIVVSEYNNMVEKINELINKVLKLEIHKKEAELKALEAQINPHFLYNTLDTIFWK 412 Query: 425 AVMTNAKEISSILKALGEFYRISLSNGQELIAAAQEKRHLESYLYIQQIRFK-KLNYRIS 483 A ++ EIS ++ +L +R++L+ G E I EK +E YL++Q R+K +L Y I Sbjct: 413 AEKSHDSEISEMIYSLSRLFRLTLNRGSEFIQVKGEKELIEHYLFLQSKRYKNRLQYSIE 472 Query: 484 FEPGIESCQVPTMLLQPLVENAIHHGIRGMPDGGLCEITGSMERSGEERILCFIVRDNGK 543 +P I +P ++LQP VENAI HG+ +ITG E GE LCF ++DNG Sbjct: 473 IDPEILDYYIPKLILQPFVENAIVHGMENSTTPTFIQITGKKE--GEN--LCFTIKDNGI 528 Query: 544 GMSEEEQRQI--WLSSSEEGEYSFGLKNIQDRIQLRFGEAYGIVLSSEPGHGVEVKVRLP 601 GMS+ + +I L S +E + + +KN+ +R++L + + + + S+PG G EVK+ LP Sbjct: 529 GMSKTQLDRIKDLLESGKEATFGYAIKNVNERLKLYYETHFKLNIQSQPGQGTEVKLILP 588 Query: 602 L 602 + Sbjct: 589 I 589 >Q8R7Q4.1 Q8R7Q4_THETN Predicted ATPase Length = 593 Score = 211 bits (537), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 163/597 (27%), Positives = 287/597 (48%), Gaps = 40/597 (6%) Query: 26 MPLRRKILISNILIVLLALMIFVLSIHRIVFNQTLGRTSASSQQEVKLVSQSMKTVFQSV 85 + +R KILI IV++ ++ V + I NQ S ++ K ++ S+ + + V Sbjct: 12 LNIRHKILILFYGIVVITSLLIVFFSYTISINQLKKEVGNSLLRDTKRIAASIDFLQRDV 71 Query: 86 QNFSKFALINQDTQNVLSRDTG-ADGDVSPLKSIHNTLAAMLETEPNIDSVIIESIGGDL 144 S F +++Q QN +S + + PL A++L ++ I + + S GD Sbjct: 72 NELSSFLVLDQRIQNFISPHSDFTKYSLGPL-------ASLLASKDYISFIALYSFQGDK 124 Query: 145 YYTSNLTGVTPQSLAIYPKD----KIDAAKGGAVWVDTLKPSFLSGMTAKN---MISVCR 197 YY SN + L + + ++ G +W+ F + KN I++ R Sbjct: 125 YYFSNDSSTLIMDLELIKRTSFYREVLEKNGAPMWLSLENLPF--DLIIKNNYPKIAMAR 182 Query: 198 VIMSMEKGTPIGYIYVNIDERTLARLY-HNEQDNQNPTLVVNQEGVVISAYEAALVSRTV 256 V++ P G + + I+ T+ ++Y N ++ ++ + ++ G +IS +++ T Sbjct: 183 VLLDFNTYKPEGLLVICINIPTIEKVYSENLKEKESAFFIADRNGNIIS-FKSTFSGFTP 241 Query: 257 ED--HSLARWVKSASGGSRTERVGDKPYLVSLQRLDPYGWKVIHLVPTSELTNG----YW 310 + + LA+++K + LV+ + W+++ +V N + Sbjct: 242 KSAQNILAKYLKDKQNV--VININSSKLLVTSSPIPTSDWRLVSVVSLKNAINSIRISFI 299 Query: 311 KIALSIAVFGLISMLSAMVLSFVFARRLTRPLSELSEVIVEVGAGNFERRAS--AGSQDE 368 + L I VF L L A ++S F+R LT PL L+ + +V GN E + S+DE Sbjct: 300 EFYLRILVFCL---LFAFLVSMYFSRALTHPLERLANSMKKVRQGNLEEKVEFEYHSKDE 356 Query: 369 VGRLGATFNEMVEHIQDLMLTIXXXXXXXXXXXXXXXYSQIKPHFLYNTLDTIRAMAVMT 428 + + +N MVE I DL+ I +QI PHFLYNTLDTI A Sbjct: 357 IAIVIKEYNRMVERINDLINRILKLEINKREAELKALEAQINPHFLYNTLDTIFWKAEKA 416 Query: 429 NAKEISSILKALGEFYRISLSNGQELIAAAQEKRHLESYLYIQQIRFK-KLNYRISFEPG 487 +E+S ++ +L +R++L+ G+E I EK +E YL++Q R+K K Y + Sbjct: 417 KDRELSEMIYSLSRLFRLTLNRGEEFIQVRGEKELIERYLFLQSKRYKNKFKYSVKISDE 476 Query: 488 IESCQVPTMLLQPLVENAIHHGIRGMPDGGLCEITGSMERSGEERILCFIVRDNGKGMSE 547 I +P ++LQP VENAI HG+ + E+ G E+ GE L FI++DNG GMSE Sbjct: 477 ILDYYIPKLILQPFVENAIVHGLENNSEESFVEVIG--EKEGEN--LKFIIKDNGPGMSE 532 Query: 548 E--EQRQIWLSSSE-EGEYSFGLKNIQDRIQLRFGEAYGIVLSSEPGHGVEVKVRLP 601 E E+ + ++ S E + + ++N+ +R++L +G+ Y + + S G G + + LP Sbjct: 533 ETLEKLKRFIESENIEEKVGYAIRNVNERLRLYYGDKYELKIESRQGEGTTISLILP 589 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.319 0.134 0.375 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,237,580,465 Number of extensions: 126398292 Number of successful extensions: 378523 Number of sequences better than 1.0e-05: 2210 Number of HSP's gapped: 375468 Number of HSP's successfully gapped: 2210 Length of query: 615 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 473 Effective length of database: 1,722,912,073 Effective search space: 814937410529 Effective search space used: 814937410529 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 134 (56.2 bits)