BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0178.0022.p (475 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Q5L028.1 Q5L028_GEOKA Dihydropyrimidinase (D-hydantoinase) EC=3.... 717 0.0 Q45515.1 HYDA_BACST D-hydantoinase EC=3.5.2.- 717 0.0 C3J120.1 C3J120_9BACI Dihydropyrimidinase 716 0.0 B7Y9X1.1 B7Y9X1_9BACI Dihydropyrimidinase 716 0.0 Q56S49.1 Q56S49_9BACI Dihydropyrimidinase 716 0.0 >Q5L028.1 Q5L028_GEOKA Dihydropyrimidinase (D-hydantoinase) EC=3.5.2.2 Length = 472 Score = 717 bits (1851), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/460 (73%), Positives = 392/460 (85%) Query: 1 MKKMIKNGIIVTAADTYAGDVLIEDGIIAGIGLNLEAPGAEIIDASGCYVFPGGIDPHTH 60 M K+IKNG IVTA D Y D+LI+DG IA IG NL+ GAE+IDA+GCYVFPGGIDPHTH Sbjct: 2 MTKLIKNGTIVTATDIYEADLLIQDGKIAVIGRNLDESGAEVIDATGCYVFPGGIDPHTH 61 Query: 61 LDMPFGGTVTADDFEXXXXXXXXXXXXXXIDFCLTAKGQPLQQAVDTWHHKSQDKAVIDY 120 LDMPFGGTVT DDFE IDFCLT KG+PL++A++TWH+K+ KAVIDY Sbjct: 62 LDMPFGGTVTKDDFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNKATGKAVIDY 121 Query: 121 SFHLMVSELNDKVLGELPQIIENEGITSLKVFMAYKNTFQADDGVLYKTLQAAKREGALV 180 FHLM+SE+ D VL ELP++IE EGITS KVFMAYK+ FQADDG LY+TL AAK GALV Sbjct: 122 GFHLMISEITDDVLEELPKVIEEEGITSFKVFMAYKDVFQADDGTLYRTLVAAKELGALV 181 Query: 181 MVHAENGDVIEYLVEQALAAGNTDPIYHALTRPPELEGEATGRAAYLTELTGSQLYVVHV 240 MVHAENGDVI+YL ++AL G+TDPIYHALTRPPELEGEATGRA LTEL GSQLYVVHV Sbjct: 182 MVHAENGDVIDYLTKKALEDGHTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHV 241 Query: 241 TCAEAAWKIAEARRKGLRVYGETCPQYLVLDQTALEKPDFEGAKYVWSPPLREEWNQAVL 300 +CA+A KIAEAR KGL V+GETCPQYLVLDQ+ LEKP+FEGAKYVWSPPLRE+W+Q VL Sbjct: 242 SCAQAVEKIAEARNKGLNVWGETCPQYLVLDQSYLEKPNFEGAKYVWSPPLREKWHQEVL 301 Query: 301 WDALWSGALQTIGSDQCSFNFKGQKDLGLGDFSKIPNGGPTIEDRFSVLYSEGVQKGRIS 360 W+AL +G LQT+GSDQCSF+FKGQK+LG GDF+KIPNGGP IEDR S+L+SEGV+KGRI+ Sbjct: 302 WNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRIT 361 Query: 361 LNKFVDIISTSSAKLFGLFPQKGTIAVGSDADIVIFDPSVERTLSAETHHMNVDYNPFEG 420 LN+FVDI+ST AKLFGLFP+KGTIAVG+DAD+VIFDP+VER +SAETHHM VDYNPFEG Sbjct: 362 LNQFVDIVSTRIAKLFGLFPKKGTIAVGADADLVIFDPTVERVISAETHHMAVDYNPFEG 421 Query: 421 MEVKGEPVSVLSRGKFVIRDKQFVGQAGSGKYLHRKRFEA 460 M+V GEPVSVL RG+FV+RDKQFVG+ G G+Y+ R ++ A Sbjct: 422 MKVTGEPVSVLCRGEFVVRDKQFVGKPGYGQYVKRAKYGA 461 >Q45515.1 HYDA_BACST D-hydantoinase EC=3.5.2.- Length = 471 Score = 717 bits (1850), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/460 (73%), Positives = 392/460 (85%) Query: 1 MKKMIKNGIIVTAADTYAGDVLIEDGIIAGIGLNLEAPGAEIIDASGCYVFPGGIDPHTH 60 M K+IKNG IVTA D Y D+LI+DG IA IG NL+ GAE+IDA+GCYVFPGGIDPHTH Sbjct: 1 MTKLIKNGTIVTATDIYEADLLIQDGKIAVIGRNLDESGAEVIDATGCYVFPGGIDPHTH 60 Query: 61 LDMPFGGTVTADDFEXXXXXXXXXXXXXXIDFCLTAKGQPLQQAVDTWHHKSQDKAVIDY 120 LDMPFGGTVT DDFE IDFCLT KG+PL++A++TWH+K+ KAVIDY Sbjct: 61 LDMPFGGTVTKDDFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNKATGKAVIDY 120 Query: 121 SFHLMVSELNDKVLGELPQIIENEGITSLKVFMAYKNTFQADDGVLYKTLQAAKREGALV 180 FHLM+SE+ D VL ELP++IE EGITS KVFMAYK+ FQADDG LY+TL AAK GALV Sbjct: 121 GFHLMISEITDDVLEELPKVIEEEGITSFKVFMAYKDVFQADDGTLYRTLVAAKELGALV 180 Query: 181 MVHAENGDVIEYLVEQALAAGNTDPIYHALTRPPELEGEATGRAAYLTELTGSQLYVVHV 240 MVHAENGDVI+YL ++AL G+TDPIYHALTRPPELEGEATGRA LTEL GSQLYVVHV Sbjct: 181 MVHAENGDVIDYLTKKALEDGHTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHV 240 Query: 241 TCAEAAWKIAEARRKGLRVYGETCPQYLVLDQTALEKPDFEGAKYVWSPPLREEWNQAVL 300 +CA+A KIAEAR KGL V+GETCPQYLVLDQ+ LEKP+FEGAKYVWSPPLRE+W+Q VL Sbjct: 241 SCAQAVEKIAEARNKGLNVWGETCPQYLVLDQSYLEKPNFEGAKYVWSPPLREKWHQEVL 300 Query: 301 WDALWSGALQTIGSDQCSFNFKGQKDLGLGDFSKIPNGGPTIEDRFSVLYSEGVQKGRIS 360 W+AL +G LQT+GSDQCSF+FKGQK+LG GDF+KIPNGGP IEDR S+L+SEGV+KGRI+ Sbjct: 301 WNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRIT 360 Query: 361 LNKFVDIISTSSAKLFGLFPQKGTIAVGSDADIVIFDPSVERTLSAETHHMNVDYNPFEG 420 LN+FVDI+ST AKLFGLFP+KGTIAVG+DAD+VIFDP+VER +SAETHHM VDYNPFEG Sbjct: 361 LNQFVDIVSTRIAKLFGLFPKKGTIAVGADADLVIFDPTVERVISAETHHMAVDYNPFEG 420 Query: 421 MEVKGEPVSVLSRGKFVIRDKQFVGQAGSGKYLHRKRFEA 460 M+V GEPVSVL RG+FV+RDKQFVG+ G G+Y+ R ++ A Sbjct: 421 MKVTGEPVSVLCRGEFVVRDKQFVGKPGYGQYVKRAKYGA 460 >C3J120.1 C3J120_9BACI Dihydropyrimidinase Length = 472 Score = 716 bits (1849), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/460 (73%), Positives = 391/460 (85%) Query: 1 MKKMIKNGIIVTAADTYAGDVLIEDGIIAGIGLNLEAPGAEIIDASGCYVFPGGIDPHTH 60 M K+IKNG IVTA D Y D+LI+ G IA IG NL+ GAE+IDA+GCYVFPGGIDPHTH Sbjct: 2 MTKLIKNGTIVTATDIYEADLLIQGGKIAVIGRNLDESGAEVIDATGCYVFPGGIDPHTH 61 Query: 61 LDMPFGGTVTADDFEXXXXXXXXXXXXXXIDFCLTAKGQPLQQAVDTWHHKSQDKAVIDY 120 LDMPFGGTVT DDFE IDFCLT KG+PL++A++TWH+K+ KAVIDY Sbjct: 62 LDMPFGGTVTKDDFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNKATGKAVIDY 121 Query: 121 SFHLMVSELNDKVLGELPQIIENEGITSLKVFMAYKNTFQADDGVLYKTLQAAKREGALV 180 FHLM+SE+ D VL ELP++IE EGITS KVFMAYKN FQADDG LY+TL AAK GALV Sbjct: 122 GFHLMISEITDDVLEELPKVIEEEGITSFKVFMAYKNVFQADDGTLYRTLVAAKELGALV 181 Query: 181 MVHAENGDVIEYLVEQALAAGNTDPIYHALTRPPELEGEATGRAAYLTELTGSQLYVVHV 240 MVHAENGDVI+YL ++AL G+TDPIYHALTRPPELEGEATGRA LTEL GSQLYVVHV Sbjct: 182 MVHAENGDVIDYLTKKALEDGHTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHV 241 Query: 241 TCAEAAWKIAEARRKGLRVYGETCPQYLVLDQTALEKPDFEGAKYVWSPPLREEWNQAVL 300 +CA+A KIAEAR KGL V+GETCPQYLVLDQ+ LEKP+FEGAKYVWSPPLRE+W+Q VL Sbjct: 242 SCAQAVEKIAEARNKGLNVWGETCPQYLVLDQSYLEKPNFEGAKYVWSPPLREKWHQEVL 301 Query: 301 WDALWSGALQTIGSDQCSFNFKGQKDLGLGDFSKIPNGGPTIEDRFSVLYSEGVQKGRIS 360 W+AL +G LQT+GSDQCSF+FKGQK+LG GDF+KIPNGGP IEDR S+L+SEGV+KGRI+ Sbjct: 302 WNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRIT 361 Query: 361 LNKFVDIISTSSAKLFGLFPQKGTIAVGSDADIVIFDPSVERTLSAETHHMNVDYNPFEG 420 LN+FVDI+ST AKLFGLFP+KGTIAVG+DAD+VIFDP+VER +SAETHHM VDYNPFEG Sbjct: 362 LNQFVDIVSTRIAKLFGLFPKKGTIAVGADADLVIFDPTVERVISAETHHMAVDYNPFEG 421 Query: 421 MEVKGEPVSVLSRGKFVIRDKQFVGQAGSGKYLHRKRFEA 460 M+V GEPVSVL RG+FV+RDKQFVG+ G G+Y+ R ++ A Sbjct: 422 MKVTGEPVSVLCRGEFVVRDKQFVGKPGYGQYVKRAKYGA 461 >B7Y9X1.1 B7Y9X1_9BACI Dihydropyrimidinase Length = 472 Score = 716 bits (1849), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/460 (73%), Positives = 391/460 (85%) Query: 1 MKKMIKNGIIVTAADTYAGDVLIEDGIIAGIGLNLEAPGAEIIDASGCYVFPGGIDPHTH 60 M K+IKNG IVTA D Y D+LI+ G IA IG NL+ GAE+IDA+GCYVFPGGIDPHTH Sbjct: 2 MTKLIKNGTIVTATDIYEADLLIQGGKIAVIGRNLDESGAEVIDATGCYVFPGGIDPHTH 61 Query: 61 LDMPFGGTVTADDFEXXXXXXXXXXXXXXIDFCLTAKGQPLQQAVDTWHHKSQDKAVIDY 120 LDMPFGGTVT DDFE IDFCLT KG+PL++A++TWH+K+ KAVIDY Sbjct: 62 LDMPFGGTVTKDDFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNKATGKAVIDY 121 Query: 121 SFHLMVSELNDKVLGELPQIIENEGITSLKVFMAYKNTFQADDGVLYKTLQAAKREGALV 180 FHLM+SE+ D VL ELP++IE EGITS KVFMAYKN FQADDG LY+TL AAK GALV Sbjct: 122 GFHLMISEITDDVLEELPKVIEEEGITSFKVFMAYKNVFQADDGTLYRTLVAAKELGALV 181 Query: 181 MVHAENGDVIEYLVEQALAAGNTDPIYHALTRPPELEGEATGRAAYLTELTGSQLYVVHV 240 MVHAENGDVI+YL ++AL G+TDPIYHALTRPPELEGEATGRA LTEL GSQLYVVHV Sbjct: 182 MVHAENGDVIDYLTKKALEDGHTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHV 241 Query: 241 TCAEAAWKIAEARRKGLRVYGETCPQYLVLDQTALEKPDFEGAKYVWSPPLREEWNQAVL 300 +CA+A KIAEAR KGL V+GETCPQYLVLDQ+ LEKP+FEGAKYVWSPPLRE+W+Q VL Sbjct: 242 SCAQAVEKIAEARNKGLNVWGETCPQYLVLDQSYLEKPNFEGAKYVWSPPLREKWHQEVL 301 Query: 301 WDALWSGALQTIGSDQCSFNFKGQKDLGLGDFSKIPNGGPTIEDRFSVLYSEGVQKGRIS 360 W+AL +G LQT+GSDQCSF+FKGQK+LG GDF+KIPNGGP IEDR S+L+SEGV+KGRI+ Sbjct: 302 WNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRIT 361 Query: 361 LNKFVDIISTSSAKLFGLFPQKGTIAVGSDADIVIFDPSVERTLSAETHHMNVDYNPFEG 420 LN+FVDI+ST AKLFGLFP+KGTIAVG+DAD+VIFDP+VER +SAETHHM VDYNPFEG Sbjct: 362 LNQFVDIVSTRIAKLFGLFPKKGTIAVGADADLVIFDPTVERVISAETHHMAVDYNPFEG 421 Query: 421 MEVKGEPVSVLSRGKFVIRDKQFVGQAGSGKYLHRKRFEA 460 M+V GEPVSVL RG+FV+RDKQFVG+ G G+Y+ R ++ A Sbjct: 422 MKVTGEPVSVLCRGEFVVRDKQFVGKPGYGQYVKRAKYGA 461 >Q56S49.1 Q56S49_9BACI Dihydropyrimidinase Length = 472 Score = 716 bits (1847), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/458 (73%), Positives = 391/458 (85%) Query: 1 MKKMIKNGIIVTAADTYAGDVLIEDGIIAGIGLNLEAPGAEIIDASGCYVFPGGIDPHTH 60 MKK+IKNG IVTAAD Y DVLIEDG IA IG ++ AEIIDA GCYVFPGGIDPHTH Sbjct: 1 MKKLIKNGTIVTAADVYHADVLIEDGKIAAIGEHVSPHDAEIIDAKGCYVFPGGIDPHTH 60 Query: 61 LDMPFGGTVTADDFEXXXXXXXXXXXXXXIDFCLTAKGQPLQQAVDTWHHKSQDKAVIDY 120 LDMPFGGTVT DDF+ IDFCLT KG+PL +A++TWH+K++ K VIDY Sbjct: 61 LDMPFGGTVTKDDFQSGTIAAAFGGTTTVIDFCLTNKGEPLAKAIETWHNKAKAKPVIDY 120 Query: 121 SFHLMVSELNDKVLGELPQIIENEGITSLKVFMAYKNTFQADDGVLYKTLQAAKREGALV 180 FHLM+SE+ND VL ELP++IE EGITS KVFMAYKN FQADDG LY+TL AAK+ GALV Sbjct: 121 GFHLMISEINDDVLSELPKVIEEEGITSFKVFMAYKNVFQADDGTLYRTLSAAKQLGALV 180 Query: 181 MVHAENGDVIEYLVEQALAAGNTDPIYHALTRPPELEGEATGRAAYLTELTGSQLYVVHV 240 MVHAENGDVI+YL++QALA G+T+PIYHALTRPPELEGEATGRA LT+L SQLYVVHV Sbjct: 181 MVHAENGDVIDYLIKQALAEGHTEPIYHALTRPPELEGEATGRACQLTQLADSQLYVVHV 240 Query: 241 TCAEAAWKIAEARRKGLRVYGETCPQYLVLDQTALEKPDFEGAKYVWSPPLREEWNQAVL 300 +CA+A KIAEAR KGL V+GETCPQYLVLDQ+ LEKP+FEGAKYVWSPPLRE+W+Q VL Sbjct: 241 SCAQAVEKIAEARNKGLNVWGETCPQYLVLDQSYLEKPNFEGAKYVWSPPLREKWHQEVL 300 Query: 301 WDALWSGALQTIGSDQCSFNFKGQKDLGLGDFSKIPNGGPTIEDRFSVLYSEGVQKGRIS 360 W+AL +G LQT+GSDQCSF+FKGQK+LG DF+KIPNGGP IEDR S+L+SEGV+KGRI+ Sbjct: 301 WNALKNGQLQTLGSDQCSFDFKGQKELGRDDFTKIPNGGPIIEDRLSILFSEGVKKGRIT 360 Query: 361 LNKFVDIISTSSAKLFGLFPQKGTIAVGSDADIVIFDPSVERTLSAETHHMNVDYNPFEG 420 LN+FVDI ST AKLFGLFP+KGTIAVGSDAD+VIFDP+VER +SAETHHM VDYNPFEG Sbjct: 361 LNQFVDITSTRIAKLFGLFPKKGTIAVGSDADLVIFDPNVERVISAETHHMAVDYNPFEG 420 Query: 421 MEVKGEPVSVLSRGKFVIRDKQFVGQAGSGKYLHRKRF 458 M+V GEP+SVLSRG+FV+RDK FVG+ G G+YL R+++ Sbjct: 421 MKVAGEPISVLSRGEFVVRDKVFVGKPGYGQYLKREKY 458 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.317 0.136 0.405 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,870,802,333 Number of extensions: 122403903 Number of successful extensions: 284531 Number of sequences better than 1.0e-05: 1927 Number of HSP's gapped: 280660 Number of HSP's successfully gapped: 1952 Length of query: 475 Length of database: 3,060,696,203 Length adjustment: 140 Effective length of query: 335 Effective length of database: 1,741,754,103 Effective search space: 583487624505 Effective search space used: 583487624505 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 133 (55.8 bits)