BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0178.0021.p (429 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B1DD85.1 B1DD85_9BACL Dihydroorotate dehydrogenase family protei... 703 0.0 A6CS58.1 A6CS58_9BACI Dihydropyrimidine dehydrogenase EC=1.3.1.1 692 0.0 A3I8S2.1 A3I8S2_9BACI Dihydropyrimidine dehydrogenase EC=1.3.1.1 677 0.0 B1HU37.1 B1HU37_LYSSC Dihydropyrimidine dehydrogenase 672 0.0 C3J121.1 C3J121_9BACI Dihydroorotate dehydrogenase family protei... 669 0.0 >B1DD85.1 B1DD85_9BACL Dihydroorotate dehydrogenase family protein EC=1.3.1.2 Length = 434 Score = 703 bits (1814), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/422 (79%), Positives = 364/422 (86%) Query: 1 MADLSIDLAGIKSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLGDPIINTSSRFAA 60 MADL I+LAGI SPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLGDPIINTSSRFAA Sbjct: 1 MADLRINLAGISSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLGDPIINTSSRFAA 60 Query: 61 VHFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVASLMVEPKQEKWHEIVKR 120 VHFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVV SLMVEPK+EKWHEIVK+ Sbjct: 61 VHFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVVSLMVEPKREKWHEIVKK 120 Query: 121 AEAVGVDGLELNFGCPHGMAERGMGAASGQQPDLVEAQTYWVKEVAATPVIVKLTPNITD 180 EAVGVDGLELNFGCPHGMAERGMG+ASGQQPDLVEAQT W KE A TPVIVKLTPNITD Sbjct: 121 VEAVGVDGLELNFGCPHGMAERGMGSASGQQPDLVEAQTMWAKEAAKTPVIVKLTPNITD 180 Query: 181 ITVVARHAVKGGADAISLINTINSLAGVDIHSWNTIPNVGGQGAHGGYCGPAVKPIALSM 240 IT A+ AV+GGADAISLINTINSLAGVD+ +WNTIP+VGG+GAHGGYCGPAVKPIAL+M Sbjct: 181 ITATAKAAVRGGADAISLINTINSLAGVDLDTWNTIPHVGGKGAHGGYCGPAVKPIALNM 240 Query: 241 VAECARDRXXXXXXXXXXXXXTWQDVVEFMLMGSTGIQVCTAVMHHGFRIVGEMIDGLNN 300 VAECAR+ W+D VEFMLMG+TG+QVCTA MHHGF IV +MIDGLNN Sbjct: 241 VAECARNAQVNVPISGIGGVSNWRDAVEFMLMGATGVQVCTAAMHHGFSIVEDMIDGLNN 300 Query: 301 YLDDKGLASVTELIGKSVPKYSNWGDLDLNYKVVARXXXXXXXXXXKCHIACEDASHQCI 360 YLDDKGL+SVTELIGKSV +YS+WGDLDLNY+VVAR KCHIACED SHQCI Sbjct: 301 YLDDKGLSSVTELIGKSVSRYSDWGDLDLNYQVVARIHEENCIVCNKCHIACEDTSHQCI 360 Query: 361 DMLTDAGGKAILHVREEDCVGCNLCSIVCPADGAIDMVALDSGAVPMSWNQRQKVISSLN 420 + LT G+A L VREEDCVGCNLCSIVCP +GAI MV + SG +PMSWN RQK ++S+ Sbjct: 361 ERLTTDDGRAYLKVREEDCVGCNLCSIVCPVEGAISMVEIPSGELPMSWNARQKAVASVG 420 Query: 421 GS 422 S Sbjct: 421 DS 422 >A6CS58.1 A6CS58_9BACI Dihydropyrimidine dehydrogenase EC=1.3.1.1 Length = 428 Score = 692 bits (1785), Expect = 0.0, Method: Compositional matrix adjust. Identities = 324/416 (77%), Positives = 362/416 (87%) Query: 1 MADLSIDLAGIKSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLGDPIINTSSRFAA 60 MA+L+IDLAGIKSPNPFWLASAPPTN+GYQVQRAFEAGWGGAVWKTLG+PIIN SSRFAA Sbjct: 1 MANLNIDLAGIKSPNPFWLASAPPTNSGYQVQRAFEAGWGGAVWKTLGEPIINVSSRFAA 60 Query: 61 VHFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVASLMVEPKQEKWHEIVKR 120 V FNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHA++ASLMVEPKQEKWHEIVK+ Sbjct: 61 VSFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAIIASLMVEPKQEKWHEIVKK 120 Query: 121 AEAVGVDGLELNFGCPHGMAERGMGAASGQQPDLVEAQTYWVKEVAATPVIVKLTPNITD 180 EAVGVDGLELNFGCPHGMAERGMGAASGQ P+LVE QTYW KEVA TPVIVKLTPNITD Sbjct: 121 VEAVGVDGLELNFGCPHGMAERGMGAASGQVPELVEKQTYWAKEVAKTPVIVKLTPNITD 180 Query: 181 ITVVARHAVKGGADAISLINTINSLAGVDIHSWNTIPNVGGQGAHGGYCGPAVKPIALSM 240 ITV A AV+GGADA+S+INTINSLAGVD+ SWNTIP+V G+GAHGGYCGPAVKPI+L+M Sbjct: 181 ITVTAEAAVQGGADAVSMINTINSLAGVDLDSWNTIPHVAGKGAHGGYCGPAVKPISLNM 240 Query: 241 VAECARDRXXXXXXXXXXXXXTWQDVVEFMLMGSTGIQVCTAVMHHGFRIVGEMIDGLNN 300 VAECAR+ WQD VEF+LMG++G+QVCTA MHHGFRIV +MIDGLNN Sbjct: 241 VAECARNPRVNVPISGMGGVSNWQDAVEFILMGASGVQVCTAAMHHGFRIVEDMIDGLNN 300 Query: 301 YLDDKGLASVTELIGKSVPKYSNWGDLDLNYKVVARXXXXXXXXXXKCHIACEDASHQCI 360 YLD+KG+ASV +++GKSVPKYS+WG+LDLNY VVA+ KCHIACED SHQCI Sbjct: 301 YLDEKGIASVQDIVGKSVPKYSDWGNLDLNYSVVAKINNDVCINCNKCHIACEDTSHQCI 360 Query: 361 DMLTDAGGKAILHVREEDCVGCNLCSIVCPADGAIDMVALDSGAVPMSWNQRQKVI 416 DML D+ G + L VREEDCVGCNLCSIVCP DGAIDM+ + SG +PM+WN+RQ + Sbjct: 361 DMLKDSSGNSYLKVREEDCVGCNLCSIVCPVDGAIDMIEVPSGHMPMTWNERQAAV 416 >A3I8S2.1 A3I8S2_9BACI Dihydropyrimidine dehydrogenase EC=1.3.1.1 Length = 427 Score = 677 bits (1748), Expect = 0.0, Method: Compositional matrix adjust. Identities = 321/420 (76%), Positives = 357/420 (85%), Gaps = 1/420 (0%) Query: 1 MADLSIDLAGIKSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLGDPIINTSSRFAA 60 MADL I+LAGI+SPNPFWLASAPPTN+GYQVQRAFEAGWGGAVWKTLGDPI+N SSRFAA Sbjct: 8 MADLRINLAGIQSPNPFWLASAPPTNSGYQVQRAFEAGWGGAVWKTLGDPILNVSSRFAA 67 Query: 61 VHFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVASLMVEPKQEKWHEIVKR 120 V FNGQRVAGFNNIELITDRPLEVNL+EIYETKK+FPNHA++ASLMVEPKQEKWHEIVKR Sbjct: 68 VSFNGQRVAGFNNIELITDRPLEVNLQEIYETKKKFPNHAIIASLMVEPKQEKWHEIVKR 127 Query: 121 AEAVGVDGLELNFGCPHGMAERGMGAASGQQPDLVEAQTYWVKEVAATPVIVKLTPNITD 180 E VGVDGLELNFGCPHGMAERGMG+ASGQ P+LVE QTYWVKE A TPVIVKLTPNITD Sbjct: 128 VEDVGVDGLELNFGCPHGMAERGMGSASGQVPELVEKQTYWVKEAARTPVIVKLTPNITD 187 Query: 181 ITVVARHAVKGGADAISLINTINSLAGVDIHSWNTIPNVGGQGAHGGYCGPAVKPIALSM 240 ITV A A +GGADAIS+INTINSLAGVD+ +WNT+P+V G+GAHGGYCGPAVKPIAL+M Sbjct: 188 ITVTAEAAKRGGADAISMINTINSLAGVDLDTWNTVPHVAGKGAHGGYCGPAVKPIALNM 247 Query: 241 VAECARDRXXXXXXXXXXXXXTWQDVVEFMLMGSTGIQVCTAVMHHGFRIVGEMIDGLNN 300 VAECAR+ WQD EF+LMG+TG+QVCTA MHHGF IV +MIDGLNN Sbjct: 248 VAECARNPLVNVPISGIGGISNWQDAAEFILMGATGVQVCTAAMHHGFSIVEDMIDGLNN 307 Query: 301 YLDDKGLASVTELIGKSVPKYSNWGDLDLNYKVVARXXXXXXXXXXKCHIACEDASHQCI 360 YLDDKGLASV +L+G+SV +YSNWGDLDLNYK+VA KCHIACED SHQCI Sbjct: 308 YLDDKGLASVMDLVGRSVSRYSNWGDLDLNYKIVAEINNDVCINCNKCHIACEDTSHQCI 367 Query: 361 DMLTDAGGKAILHVREEDCVGCNLCSIVCPADGAIDMVALDSGAVPMSWNQRQKVISSLN 420 D+ T+ G+ +L VREEDCVGCNLCSIVCP DGAI MV S PM+WN+RQ +ISSL+ Sbjct: 368 DLYTE-NGRPLLKVREEDCVGCNLCSIVCPVDGAISMVERKSTVPPMTWNERQSLISSLS 426 >B1HU37.1 B1HU37_LYSSC Dihydropyrimidine dehydrogenase Length = 420 Score = 672 bits (1735), Expect = 0.0, Method: Compositional matrix adjust. Identities = 317/420 (75%), Positives = 357/420 (85%), Gaps = 1/420 (0%) Query: 1 MADLSIDLAGIKSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLGDPIINTSSRFAA 60 MADL I+LAGI+SPNPFWLASAPPTN+GYQVQRAFEAGWGGAVWKTLG+PI+N SSRFAA Sbjct: 1 MADLRINLAGIQSPNPFWLASAPPTNSGYQVQRAFEAGWGGAVWKTLGEPILNVSSRFAA 60 Query: 61 VHFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVASLMVEPKQEKWHEIVKR 120 V +NGQRVAGFNNIELITDRPLEVNL+EIYETKK+FP+HA++ASLMVEPKQEKWHEIVKR Sbjct: 61 VSYNGQRVAGFNNIELITDRPLEVNLQEIYETKKKFPHHAIIASLMVEPKQEKWHEIVKR 120 Query: 121 AEAVGVDGLELNFGCPHGMAERGMGAASGQQPDLVEAQTYWVKEVAATPVIVKLTPNITD 180 E VGVDGLELNFGCPHGMAERGMG+ASGQ P+LVE QTYWVKE A TPVIVKLTPNITD Sbjct: 121 VEDVGVDGLELNFGCPHGMAERGMGSASGQVPELVEKQTYWVKEAARTPVIVKLTPNITD 180 Query: 181 ITVVARHAVKGGADAISLINTINSLAGVDIHSWNTIPNVGGQGAHGGYCGPAVKPIALSM 240 ITV A A +GGADA+S+INTINSLAGVD+ +WNT+P+V G+GAHGGYCGPAVKPIAL+M Sbjct: 181 ITVTAEAATRGGADAVSMINTINSLAGVDLDTWNTVPHVAGKGAHGGYCGPAVKPIALNM 240 Query: 241 VAECARDRXXXXXXXXXXXXXTWQDVVEFMLMGSTGIQVCTAVMHHGFRIVGEMIDGLNN 300 VAECAR+ WQD EF+LMG+TG+QVCTA MHHGF IV +MIDGLNN Sbjct: 241 VAECARNPLVNVPISGIGGISNWQDAAEFILMGATGVQVCTAAMHHGFSIVEDMIDGLNN 300 Query: 301 YLDDKGLASVTELIGKSVPKYSNWGDLDLNYKVVARXXXXXXXXXXKCHIACEDASHQCI 360 YLDDKGLASV +L+G+SV +YSNWGDLDLNYK+VA KCHIACED SHQCI Sbjct: 301 YLDDKGLASVMDLVGRSVSRYSNWGDLDLNYKIVAEINNDVCINCNKCHIACEDTSHQCI 360 Query: 361 DMLTDAGGKAILHVREEDCVGCNLCSIVCPADGAIDMVALDSGAVPMSWNQRQKVISSLN 420 D+ T+ G+ +L VREEDCVGCNLCSIVCP DGAI MV S PM+WN+RQ +ISSL+ Sbjct: 361 DLYTE-NGRPLLKVREEDCVGCNLCSIVCPVDGAISMVERKSTVPPMTWNERQTLISSLS 419 >C3J121.1 C3J121_9BACI Dihydroorotate dehydrogenase family protein EC=1.3.1.2 Length = 429 Score = 669 bits (1726), Expect = 0.0, Method: Compositional matrix adjust. Identities = 319/421 (75%), Positives = 356/421 (84%) Query: 1 MADLSIDLAGIKSPNPFWLASAPPTNTGYQVQRAFEAGWGGAVWKTLGDPIINTSSRFAA 60 MADLSI+LAGIKSPNPFWLASAPPTN+GYQVQRAFEAGWGGAVWKTLG+PI+N SSRFAA Sbjct: 1 MADLSINLAGIKSPNPFWLASAPPTNSGYQVQRAFEAGWGGAVWKTLGEPILNVSSRFAA 60 Query: 61 VHFNGQRVAGFNNIELITDRPLEVNLKEIYETKKRFPNHAVVASLMVEPKQEKWHEIVKR 120 + FNGQRV GFNNIELITDRPLE NLKEIYETKKRFP+ AVVASLMVEPK+EKWHEIVKR Sbjct: 61 ISFNGQRVMGFNNIELITDRPLEENLKEIYETKKRFPDRAVVASLMVEPKREKWHEIVKR 120 Query: 121 AEAVGVDGLELNFGCPHGMAERGMGAASGQQPDLVEAQTYWVKEVAATPVIVKLTPNITD 180 E VGVDGLELNFGCPHGMAERGMG+ASGQ P+LVE QTYWVKEVA TPVIVKLTPNITD Sbjct: 121 VEDVGVDGLELNFGCPHGMAERGMGSASGQVPELVERQTYWVKEVARTPVIVKLTPNITD 180 Query: 181 ITVVARHAVKGGADAISLINTINSLAGVDIHSWNTIPNVGGQGAHGGYCGPAVKPIALSM 240 IT A A +GGADAISLINTINSL GVD+ +WNTIP+V G+GAHGGYCGPAVKPIAL+M Sbjct: 181 ITATAEAAAQGGADAISLINTINSLMGVDLDTWNTIPHVAGKGAHGGYCGPAVKPIALNM 240 Query: 241 VAECARDRXXXXXXXXXXXXXTWQDVVEFMLMGSTGIQVCTAVMHHGFRIVGEMIDGLNN 300 VAECAR W+D VEFMLMG+TG+QVCTAVMHHGFRI+ +MI+GLN+ Sbjct: 241 VAECARHPRIRIPISGIGGISNWRDAVEFMLMGATGVQVCTAVMHHGFRIIEDMIEGLNH 300 Query: 301 YLDDKGLASVTELIGKSVPKYSNWGDLDLNYKVVARXXXXXXXXXXKCHIACEDASHQCI 360 YLD+KG+ASV +++GKSV KYS+WGDLDLNYKVVAR KC+I+CEDASHQCI Sbjct: 301 YLDEKGIASVMDIVGKSVSKYSDWGDLDLNYKVVARIHRERCIQCNKCYISCEDASHQCI 360 Query: 361 DMLTDAGGKAILHVREEDCVGCNLCSIVCPADGAIDMVALDSGAVPMSWNQRQKVISSLN 420 + L D GK L VREEDCVGCNLCSIVCP DGAI+MV + S PM+WN+RQ + L+ Sbjct: 361 ERLVDENGKEYLKVREEDCVGCNLCSIVCPVDGAIEMVEVPSEHPPMTWNERQAALGRLS 420 Query: 421 G 421 G Sbjct: 421 G 421 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.318 0.134 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,520,990,607 Number of extensions: 101769125 Number of successful extensions: 277973 Number of sequences better than 1.0e-05: 895 Number of HSP's gapped: 275207 Number of HSP's successfully gapped: 897 Length of query: 429 Length of database: 3,060,696,203 Length adjustment: 139 Effective length of query: 290 Effective length of database: 1,751,175,118 Effective search space: 507840784220 Effective search space used: 507840784220 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 133 (55.8 bits)