BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0176.0005.p (322 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KL14.1 B3KL14_9BACI Delta-aminolevulinic acid dehydratase EC=4... 548 e-154 B1DDS8.1 B1DDS8_9BACL Delta-aminolevulinic acid dehydratase EC=4... 494 e-138 Q5KWK8.1 Q5KWK8_GEOKA Delta-aminolevulinic acid dehydratase EC=4... 469 e-130 C3IY20.1 C3IY20_9BACI Porphobilinogen synthase EC=4.2.1.24 468 e-130 B7Y655.1 B7Y655_9BACI Delta-aminolevulinic acid dehydratase EC=4... 468 e-130 >B3KL14.1 B3KL14_9BACI Delta-aminolevulinic acid dehydratase EC=4.2.1.24 Length = 332 Score = 548 bits (1412), Expect = e-154, Method: Compositional matrix adjust. Identities = 258/322 (80%), Positives = 290/322 (90%) Query: 1 LRGTAGIRGMVRETILNTLDFIQPIFVTYGTGVKNEISSMPGVYHFSLDTLKAEVDEIAA 60 LR AGIR MVRET+L+T D +QPIFVTYG+GVK+EISSMPGVYHFSLDTLK EVDEI Sbjct: 11 LRQNAGIRSMVRETVLHTEDLVQPIFVTYGSGVKSEISSMPGVYHFSLDTLKEEVDEIVN 70 Query: 61 LGIPAVLLFGIPETKDAVGSSAFAEDGIVQEATRLIKKWYPELLVVADTCLCEFTDHGHC 120 LGIPAVLLFGIPETKD+VG+S FA+DGIVQEATRLIK W+P+LLV+ADTCLCEFTDHGHC Sbjct: 71 LGIPAVLLFGIPETKDSVGTSGFADDGIVQEATRLIKSWHPDLLVIADTCLCEFTDHGHC 130 Query: 121 GMXXXXXXXXXXXXXXINDASLDLLTRTAVSQARAGADIIAPSNMMDGFVHAIRAGLDEN 180 GM +ND SL+LL RTAVSQA+AGADIIAPSNMMDGFV AIR+GLDE Sbjct: 131 GMVHTFERDGHTCGDVLNDESLELLVRTAVSQAKAGADIIAPSNMMDGFVQAIRSGLDEA 190 Query: 181 GFEHVPIMSYSVKYASAFYGPFREAADSAPQFGNRKTYQMDPANLREAIREADSDVLEGA 240 GF +VPIMSYSVKYASAFYGPFREAADSAPQFG+RKTYQMDPAN+REA+REA++DVLEGA Sbjct: 191 GFYNVPIMSYSVKYASAFYGPFREAADSAPQFGDRKTYQMDPANVREALREAETDVLEGA 250 Query: 241 DMLMVKPALAYLDVIRTIRDQFDLPLVAYNVSGEYSMVKAAALQGWIDEKAVVLEMLTGM 300 DMLMVKPA+AYLDV+R +RDQFDLP+VAYNVSGEYSM+KAAA QGWI E+A+V+E+LTGM Sbjct: 251 DMLMVKPAMAYLDVVRLLRDQFDLPIVAYNVSGEYSMIKAAAQQGWISEQAIVMELLTGM 310 Query: 301 KRAGADIIITYFAKDAARWLRG 322 KRAGADIIITYF+KDAARW+RG Sbjct: 311 KRAGADIIITYFSKDAARWMRG 332 >B1DDS8.1 B1DDS8_9BACL Delta-aminolevulinic acid dehydratase EC=4.2.1.24 Length = 331 Score = 494 bits (1273), Expect = e-138, Method: Compositional matrix adjust. Identities = 236/322 (73%), Positives = 269/322 (83%), Gaps = 2/322 (0%) Query: 1 LRGTAGIRGMVRETILNTLDFIQPIFVTYGTGVKNEISSMPGVYHFSLDTLKAEVDEIAA 60 LR +A +R +VRET+L DFI PI+V YGT +K EISSMPGVY FSLD L+AE+ EI + Sbjct: 11 LRQSAAMRNIVRETVLTANDFIYPIYVKYGTNIKEEISSMPGVYRFSLDLLEAEIREITS 70 Query: 61 LGIPAVLLFGIPETKDAVGSSAFAEDGIVQEATRLIKKWYPELLVVADTCLCEFTDHGHC 120 LGI A++LFG+P+ KDA G+SA+ +GIVQEATRLIKKW PEL+V+ADTCLC+FTDHGHC Sbjct: 71 LGIQAIMLFGLPDHKDAEGTSAYDPNGIVQEATRLIKKWAPELIVMADTCLCQFTDHGHC 130 Query: 121 GMXXXXXXXXXXXXXXINDASLDLLTRTAVSQARAGADIIAPSNMMDGFVHAIRAGLDEN 180 GM ND SL LL RTAVSQA AGAD+IAPSNMMDGFV AIR GLDE Sbjct: 131 GMVHLDQATGTAVVD--NDPSLSLLVRTAVSQAEAGADVIAPSNMMDGFVSAIREGLDEA 188 Query: 181 GFEHVPIMSYSVKYASAFYGPFREAADSAPQFGNRKTYQMDPANLREAIREADSDVLEGA 240 GF HVPI+SYSVKYASAFYGPFR+AA SAPQFG+RKTYQMDPAN REA+READSDVLEGA Sbjct: 189 GFSHVPILSYSVKYASAFYGPFRDAAKSAPQFGDRKTYQMDPANAREALREADSDVLEGA 248 Query: 241 DMLMVKPALAYLDVIRTIRDQFDLPLVAYNVSGEYSMVKAAALQGWIDEKAVVLEMLTGM 300 DMLMVKPAL+YLD++R +RD FDLP+VAYNVSGEY+MVKAAA GWIDEKA+VLE L M Sbjct: 249 DMLMVKPALSYLDIVRQLRDSFDLPIVAYNVSGEYAMVKAAAANGWIDEKAIVLEKLISM 308 Query: 301 KRAGADIIITYFAKDAARWLRG 322 KRAGAD+IITY AKDA+RWLRG Sbjct: 309 KRAGADLIITYHAKDASRWLRG 330 >Q5KWK8.1 Q5KWK8_GEOKA Delta-aminolevulinic acid dehydratase EC=4.2.1.24 Length = 324 Score = 469 bits (1206), Expect = e-130, Method: Compositional matrix adjust. Identities = 226/320 (70%), Positives = 261/320 (81%), Gaps = 8/320 (2%) Query: 1 LRGTAGIRGMVRETILNTLDFIQPIFVTYGTGVKNEISSMPGVYHFSLDTLKAEVDEIAA 60 LR TA IR MVRET L D I P+FV G+G+K E+ SMPGVYH SLD L EVD+IA Sbjct: 11 LRQTAAIRAMVRETHLRVEDLIYPLFVVEGSGIKREVPSMPGVYHLSLDRLSEEVDDIAK 70 Query: 61 LGIPAVLLFGIPETKDAVGSSAFAEDGIVQEATRLIKKWYPELLVVADTCLCEFTDHGHC 120 LGIPAV++FG+P KD VGS A+ E GIVQ A R IK + +L+V+ADTCLCE+T HGHC Sbjct: 71 LGIPAVMVFGVPNEKDEVGSQAYCETGIVQRAIRQIKAEHKDLVVIADTCLCEYTSHGHC 130 Query: 121 GMXXXXXXXXXXXXXXINDASLDLLTRTAVSQARAGADIIAPSNMMDGFVHAIRAGLDEN 180 G+ +ND SL+LLT+TAVSQA+AGADIIAPSNMMDGFV AIR GLDE Sbjct: 131 GVVENERV--------LNDPSLELLTKTAVSQAQAGADIIAPSNMMDGFVAAIRRGLDEA 182 Query: 181 GFEHVPIMSYSVKYASAFYGPFREAADSAPQFGNRKTYQMDPANLREAIREADSDVLEGA 240 GFE+VPIMSY++KYASAFYGPFR+AADSAPQFG+RKTYQMDPAN EA REA+SDV EGA Sbjct: 183 GFEYVPIMSYAIKYASAFYGPFRDAADSAPQFGDRKTYQMDPANRLEAFREAESDVKEGA 242 Query: 241 DMLMVKPALAYLDVIRTIRDQFDLPLVAYNVSGEYSMVKAAALQGWIDEKAVVLEMLTGM 300 D LMVKPALAY+D+IR ++++F LPLVAYNVSGEY+MVKAAA GWIDEK+VV+EMLTGM Sbjct: 243 DFLMVKPALAYMDIIRDVKNRFPLPLVAYNVSGEYAMVKAAAQNGWIDEKSVVMEMLTGM 302 Query: 301 KRAGADIIITYFAKDAARWL 320 KRAGAD+IITYFAKD ARWL Sbjct: 303 KRAGADLIITYFAKDVARWL 322 >C3IY20.1 C3IY20_9BACI Porphobilinogen synthase EC=4.2.1.24 Length = 324 Score = 468 bits (1204), Expect = e-130, Method: Compositional matrix adjust. Identities = 226/320 (70%), Positives = 260/320 (81%), Gaps = 8/320 (2%) Query: 1 LRGTAGIRGMVRETILNTLDFIQPIFVTYGTGVKNEISSMPGVYHFSLDTLKAEVDEIAA 60 LR TA IR MVRET L D I P+FV G+G+K E+ SMPGVYH SLD L EVD+IA Sbjct: 11 LRQTAAIRAMVRETHLRVEDLIYPLFVVEGSGIKREVPSMPGVYHLSLDRLSEEVDDIAK 70 Query: 61 LGIPAVLLFGIPETKDAVGSSAFAEDGIVQEATRLIKKWYPELLVVADTCLCEFTDHGHC 120 LGIPAV++FG+P KD VGS A+ E GIVQ A R IK + +L+V+ADTCLCE+T HGHC Sbjct: 71 LGIPAVMVFGVPNEKDEVGSQAYCETGIVQRAIRQIKAEHKDLVVIADTCLCEYTSHGHC 130 Query: 121 GMXXXXXXXXXXXXXXINDASLDLLTRTAVSQARAGADIIAPSNMMDGFVHAIRAGLDEN 180 G+ +ND SL+LLT+TAVSQA+AGADIIAPSNMMDGFV AIR GLDE Sbjct: 131 GVVENERV--------LNDPSLELLTKTAVSQAQAGADIIAPSNMMDGFVAAIRRGLDEA 182 Query: 181 GFEHVPIMSYSVKYASAFYGPFREAADSAPQFGNRKTYQMDPANLREAIREADSDVLEGA 240 GFE+VPIMSY++KYASAFYGPFR+AADSAPQFG+RKTYQMDPAN EA REA+SDV EGA Sbjct: 183 GFEYVPIMSYAIKYASAFYGPFRDAADSAPQFGDRKTYQMDPANRLEAFREAESDVKEGA 242 Query: 241 DMLMVKPALAYLDVIRTIRDQFDLPLVAYNVSGEYSMVKAAALQGWIDEKAVVLEMLTGM 300 D LMVKPALAY+D+IR ++++F LPLVAYNVSGEY+MVKAAA GWIDEK VV+EMLTGM Sbjct: 243 DFLMVKPALAYMDIIRDVKNRFPLPLVAYNVSGEYAMVKAAAQNGWIDEKPVVMEMLTGM 302 Query: 301 KRAGADIIITYFAKDAARWL 320 KRAGAD+IITYFAKD ARWL Sbjct: 303 KRAGADLIITYFAKDVARWL 322 >B7Y655.1 B7Y655_9BACI Delta-aminolevulinic acid dehydratase EC=4.2.1.24 Length = 324 Score = 468 bits (1204), Expect = e-130, Method: Compositional matrix adjust. Identities = 226/320 (70%), Positives = 260/320 (81%), Gaps = 8/320 (2%) Query: 1 LRGTAGIRGMVRETILNTLDFIQPIFVTYGTGVKNEISSMPGVYHFSLDTLKAEVDEIAA 60 LR TA IR MVRET L D I P+FV G+G+K E+ SMPGVYH SLD L EVD+IA Sbjct: 11 LRQTAAIRAMVRETHLRVEDLIYPLFVVEGSGIKREVPSMPGVYHLSLDRLSEEVDDIAK 70 Query: 61 LGIPAVLLFGIPETKDAVGSSAFAEDGIVQEATRLIKKWYPELLVVADTCLCEFTDHGHC 120 LGIPAV++FG+P KD VGS A+ E GIVQ A R IK + +L+V+ADTCLCE+T HGHC Sbjct: 71 LGIPAVMVFGVPNEKDEVGSQAYCETGIVQRAIRQIKAEHKDLVVIADTCLCEYTSHGHC 130 Query: 121 GMXXXXXXXXXXXXXXINDASLDLLTRTAVSQARAGADIIAPSNMMDGFVHAIRAGLDEN 180 G+ +ND SL+LLT+TAVSQA+AGADIIAPSNMMDGFV AIR GLDE Sbjct: 131 GVVENERV--------LNDPSLELLTKTAVSQAQAGADIIAPSNMMDGFVAAIRRGLDEA 182 Query: 181 GFEHVPIMSYSVKYASAFYGPFREAADSAPQFGNRKTYQMDPANLREAIREADSDVLEGA 240 GFE+VPIMSY++KYASAFYGPFR+AADSAPQFG+RKTYQMDPAN EA REA+SDV EGA Sbjct: 183 GFEYVPIMSYAIKYASAFYGPFRDAADSAPQFGDRKTYQMDPANRLEAFREAESDVKEGA 242 Query: 241 DMLMVKPALAYLDVIRTIRDQFDLPLVAYNVSGEYSMVKAAALQGWIDEKAVVLEMLTGM 300 D LMVKPALAY+D+IR ++++F LPLVAYNVSGEY+MVKAAA GWIDEK VV+EMLTGM Sbjct: 243 DFLMVKPALAYMDIIRDVKNRFPLPLVAYNVSGEYAMVKAAAQNGWIDEKPVVMEMLTGM 302 Query: 301 KRAGADIIITYFAKDAARWL 320 KRAGAD+IITYFAKD ARWL Sbjct: 303 KRAGADLIITYFAKDVARWL 322 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.321 0.137 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 1,755,300,929 Number of extensions: 68783857 Number of successful extensions: 175061 Number of sequences better than 1.0e-05: 1500 Number of HSP's gapped: 171306 Number of HSP's successfully gapped: 1500 Length of query: 322 Length of database: 3,060,696,203 Length adjustment: 136 Effective length of query: 186 Effective length of database: 1,779,438,163 Effective search space: 330975498318 Effective search space used: 330975498318 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 131 (55.1 bits)