BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0167.0009.p (614 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KDQ9.1 B3KDQ9_9BACI Histidine kinase internal region 607 e-171 B1D7X4.1 B1D7X4_9BACL Integral membrane sensor signal transducti... 584 e-165 Q9KBL7.1 Q9KBL7_BACHD Two-component sensor histidine kinase 452 e-125 Q5WIY4.1 Q5WIY4_BACSK Two-component sensor histidine kinase 378 e-103 B8I617.1 B8I617_CLOCE Histidine kinase 315 6e-84 >B3KDQ9.1 B3KDQ9_9BACI Histidine kinase internal region Length = 602 Score = 607 bits (1564), Expect = e-171, Method: Compositional matrix adjust. Identities = 309/589 (52%), Positives = 413/589 (70%) Query: 21 MFHWFVKLMNDIKIRNKXXXXXXXXXXXXXXXXXXXXTFEMRTMAFDNALEQASTNVDRV 80 M F++L+ND+KIRNK T E+R AFDNALEQA NVDRV Sbjct: 1 MLSNFIQLINDMKIRNKLILSFVVVVFVPVAIVGIFLTGELRKFAFDNALEQAYQNVDRV 60 Query: 81 RKRTEEVIGVSQDISYRLNNDTRLKRLAVRKYESIYEVVKAYQDYTDVREYIRLYSEISN 140 +KR+ EVI V+ D+SYRL+ D RL+ LA R+YES+Y+V AY++Y D+++ IR+Y EISN Sbjct: 61 KKRSTEVINVADDLSYRLSYDERLRNLANRQYESVYDVFVAYREYPDLQQAIRMYKEISN 120 Query: 141 IRLYTDNSSLLNNWELINPSPAIKESEWYQRAQRYEGLVGWEYIEDERDHHKYLSLVRKI 200 IR Y+DN ++LNNWE + P I+ +EWY+RA+ G++ W+YIEDERD YLSL++ + Sbjct: 121 IRFYSDNPTMLNNWEFLYPKDEIRSTEWYRRAEDDIGVIYWDYIEDERDQKVYLSLIKGV 180 Query: 201 ELEGSSKTGVLVINVNSNKLTSILNQESFDTMIVDDQNNIIASNRKEREGKTLADISFDT 260 +L GVLVINVN+ L +IL+QE+FDT+IVD NNI+A+NR E GKTLA+I + Sbjct: 181 DLGSKDNRGVLVINVNTGMLNTILSQEAFDTIIVDSSNNIVAANRPELYGKTLAEIEDAS 240 Query: 261 KLLGRGSGSYEAVVEGEPSQIVIDELSPQASRNALRVVSVFSIDSIVKEPNRIIRLALSV 320 + SGSYE+V+ E S+++I+ L+ ++ N LR++S+FSIDSIV + NRI +LA++V Sbjct: 241 GAVYHASGSYESVIHDEASKVLIEPLNTESGVNGLRIISIFSIDSIVADANRISKLAMTV 300 Query: 321 IAIXXXXXXXXXXXXXXXXXXXXXXXXKHINRVGTGDFDTSLQIDGKDEIALLARQFNSM 380 I I KHI +VGTG+ +++IDGKDEI L+RQFNSM Sbjct: 301 IIISLLLAVLLIYSFSSLISNRLLRLSKHITKVGTGNLGVAMEIDGKDEIGQLSRQFNSM 360 Query: 381 VRSIHDLMLEVQVSNEQNSLLQQKQNDIRFKMLASQINPHFLFNALESIRMEAHMKNQQE 440 V +++DLM EVQ SNEQ L++QKQN+I+FKM+ASQINPHFLFNALESIRMEAH+K + E Sbjct: 361 VGNVNDLMNEVQESNEQKRLMEQKQNEIKFKMMASQINPHFLFNALESIRMEAHLKGETE 420 Query: 441 IARVVRLLGQMMRSSLEVGRSKVTLKQELDMVRCYLEIQQFRYEERLKYHFIVDPAIESL 500 IAR+VRLLG+MMRS+LEVG K T+K E++MV+CYL+IQ+FRYE+RLKY VDP + Sbjct: 421 IARIVRLLGKMMRSNLEVGSGKTTIKDEIEMVQCYLDIQKFRYEDRLKYELQVDPEANRV 480 Query: 501 SMPPLIIQPLVENAVIHGLDNTLEGAVVTVEIRYEQEHAVFTITDNGVGITQDRLEQVRS 560 +PPLIIQPLVENAVIHG+D+ EG + V + + DNG GI+ D+L+ + Sbjct: 481 RIPPLIIQPLVENAVIHGMDHKEEGTSIKVRVTASEGKLHVMTEDNGAGISLDKLQMIYG 540 Query: 561 TLETQEEQEGARIGLRNVHDRLKLSYGEKYGLTIESHPDEGTRISFRIP 609 L +E++G RIGLRNVH RL+L+YG + GL I S P GTRI F IP Sbjct: 541 YLNDTDEKDGGRIGLRNVHVRLQLTYGPEAGLIIYSEPGIGTRIEFSIP 589 >B1D7X4.1 B1D7X4_9BACL Integral membrane sensor signal transduction histidine kinase Length = 595 Score = 584 bits (1505), Expect = e-165, Method: Compositional matrix adjust. Identities = 292/590 (49%), Positives = 398/590 (67%), Gaps = 1/590 (0%) Query: 21 MFHWFVKLMNDIKIRNKXXXXXXXXXXXXXXXXXXXXTFEMRTMAFDNALEQASTNVDRV 80 MF F L+N++K+R K T E+R MA DNA+EQ TNV RV Sbjct: 1 MFQMFSHLLNNVKLRTKLILSCIVVAFIPILIVGVFLTNELRNMALDNAMEQTHTNVQRV 60 Query: 81 RKRTEEVIGVSQDISYRLNNDTRLKRLAVRKYESIYEVVKAYQDYTDVREYIRLYSEISN 140 + RT E++ V+ D +YRL N +RL+ + RKYES YEVVKAY++YTD E + + E++N Sbjct: 61 KARTTELMNVAYDSAYRLEN-SRLEAVTNRKYESTYEVVKAYREYTDFNEIRQQHDEVAN 119 Query: 141 IRLYTDNSSLLNNWELINPSPAIKESEWYQRAQRYEGLVGWEYIEDERDHHKYLSLVRKI 200 IR Y +N ++LNNW+ I P ++KE+ WY A R V W Y+EDERD YLSLVR I Sbjct: 120 IRFYMENPTMLNNWDFIQPDNSMKETVWYANALRPGSGVNWYYLEDERDKRNYLSLVRGI 179 Query: 201 ELEGSSKTGVLVINVNSNKLTSILNQESFDTMIVDDQNNIIASNRKEREGKTLADISFDT 260 ++ +GVLVI +N L SILNQESF+TMIVDD N I+A+NR R GKTL +I ++ Sbjct: 180 SFSSNNTSGVLVITLNMQALNSILNQESFETMIVDDNNRIVAANRMGRAGKTLQEIDYEQ 239 Query: 261 KLLGRGSGSYEAVVEGEPSQIVIDELSPQASRNALRVVSVFSIDSIVKEPNRIIRLALSV 320 ++ SG Y A ++G+ S+++I+ L P+AS N LR++SVFS+D+IV + NRI LAL+V Sbjct: 240 SIVEEQSGMYSANIDGQASRVLIEPLIPEASGNTLRIISVFSVDTIVADANRINSLALTV 299 Query: 321 IAIXXXXXXXXXXXXXXXXXXXXXXXXKHINRVGTGDFDTSLQIDGKDEIALLARQFNSM 380 I+I KHI +V TG D ++IDGKDEI L+RQFNSM Sbjct: 300 ISISLVIAIFLIIGVSTIITKRMLRLSKHITKVATGKLDIVMEIDGKDEIGQLSRQFNSM 359 Query: 381 VRSIHDLMLEVQVSNEQNSLLQQKQNDIRFKMLASQINPHFLFNALESIRMEAHMKNQQE 440 V SI+ L+ EVQ SN+ L+ KQN+I+ KM+ASQINPHFLFNALESIRM+AH+K ++E Sbjct: 360 VSSINGLVEEVQESNKMKRQLEAKQNEIKLKMMASQINPHFLFNALESIRMKAHLKGEKE 419 Query: 441 IARVVRLLGQMMRSSLEVGRSKVTLKQELDMVRCYLEIQQFRYEERLKYHFIVDPAIESL 500 I++VVRLLG++MR S+EV + L E+D+VRCYL+IQ+FRYE+RL Y VDP +E + Sbjct: 420 ISQVVRLLGKLMRRSIEVSQRLTPLADEMDIVRCYLDIQKFRYEDRLSYELHVDPVVERV 479 Query: 501 SMPPLIIQPLVENAVIHGLDNTLEGAVVTVEIRYEQEHAVFTITDNGVGITQDRLEQVRS 560 S+PPLIIQPLVENAVIHG +N +EG +VTV E ++ + DNG G+T+++++++ Sbjct: 480 SIPPLIIQPLVENAVIHGFENKVEGGMVTVRAVREGDYVRVDVIDNGAGMTREKIDKLTQ 539 Query: 561 TLETQEEQEGARIGLRNVHDRLKLSYGEKYGLTIESHPDEGTRISFRIPM 610 L E+ E RIGLRNVH RL+L+YG ++GL ES P GT++SF +P Sbjct: 540 HLNETEDAENNRIGLRNVHLRLQLTYGPEHGLQYESEPGIGTKVSFTLPF 589 >Q9KBL7.1 Q9KBL7_BACHD Two-component sensor histidine kinase Length = 597 Score = 452 bits (1162), Expect = e-125, Method: Compositional matrix adjust. Identities = 240/589 (40%), Positives = 357/589 (60%), Gaps = 2/589 (0%) Query: 21 MFHWFVKLMNDIKIRNKXXXXXXXXXXXXXXXXXXXXTFEMRTMAFDNALEQASTNVDRV 80 M+ ++ +ND+K+R+K T E+R+ A +A++Q+ NV+RV Sbjct: 1 MYSTLIQTINDMKLRDKLMFMFVVVVFFPMMIVGIFLTNELRSNAIQDAIQQSRVNVERV 60 Query: 81 RKRTEEVIGVSQDISYRLNNDTRLKRLAVRKYESIYEVVKAYQDYTDVREYIRLYSEISN 140 ++RT EV+ V I+ L D R L ++YE+ Y+VV AY Y + Y++ YSEI N Sbjct: 61 KERTTEVLNVPVLIANNLQFDERFIELVNQEYETTYDVVDAYLQYMNFTNYLQYYSEIHN 120 Query: 141 IRLYTDNSSLLNNWELINPSPAIKESEWYQRAQRYEGLVGWEYIEDE-RDHHKYLSLVRK 199 ++ Y++N+SL+NNW +I P EW++ A W Y+EDE + + YLS+V++ Sbjct: 121 MKYYSENTSLMNNWVII-PVEHEAGEEWFKEAMADPAYYRWFYLEDETKKNQAYLSMVKR 179 Query: 200 IELEGSSKTGVLVINVNSNKLTSILNQESFDTMIVDDQNNIIASNRKEREGKTLADISFD 259 + GVLVI V+ KL IL QESF TMIVD++N I A+N++E GK L ++ Sbjct: 180 LNFLEYGSAGVLVITVDPRKLDRILQQESFTTMIVDERNRIAATNQREYIGKDLHEVIDF 239 Query: 260 TKLLGRGSGSYEAVVEGEPSQIVIDELSPQASRNALRVVSVFSIDSIVKEPNRIIRLALS 319 +++ G YE + GEPSQI++D L+ Q S++ L+++S+ + + I+K+ R+ + + Sbjct: 240 HEMIQEGPAIYEGKMNGEPSQIIVDYLTLQMSQSELKIISIVTKEHIMKDAKRLSIMGAT 299 Query: 320 VIAIXXXXXXXXXXXXXXXXXXXXXXXXKHINRVGTGDFDTSLQIDGKDEIALLARQFNS 379 V + IN+V +GD T + +DGKDEI L+ QFN Sbjct: 300 VTMGGMAVAVLLIVHFSWLISKRLSHLSERINQVASGDLKTKIVVDGKDEIGQLSVQFNQ 359 Query: 380 MVRSIHDLMLEVQVSNEQNSLLQQKQNDIRFKMLASQINPHFLFNALESIRMEAHMKNQQ 439 MV ++ L+ +V +N Q LL++ QN+I+ KMLASQINPHFLFN LESIRM++HMK + Sbjct: 360 MVANLRSLIHQVHETNRQKRLLEKSQNEIKLKMLASQINPHFLFNTLESIRMKSHMKGET 419 Query: 440 EIARVVRLLGQMMRSSLEVGRSKVTLKQELDMVRCYLEIQQFRYEERLKYHFIVDPAIES 499 EIA+VV+ LG++MR SLEV + L+ ELDMVRCYLEIQ FRY +RL Y +DP E Sbjct: 420 EIAKVVKQLGKLMRKSLEVTGHHIPLRNELDMVRCYLEIQTFRYGDRLHYELYIDPQSEM 479 Query: 500 LSMPPLIIQPLVENAVIHGLDNTLEGAVVTVEIRYEQEHAVFTITDNGVGITQDRLEQVR 559 + + PLIIQPLVENAVIHGL+ T +G VT+ + D+G G+ +++LE ++ Sbjct: 480 VEILPLIIQPLVENAVIHGLERTEDGGTVTISTIVNGNDLTVIVNDDGCGMDEEKLEAIQ 539 Query: 560 STLETQEEQEGARIGLRNVHDRLKLSYGEKYGLTIESHPDEGTRISFRI 608 + L +E +G +IGL NVH RL+L+YG+ GL IES +GT + F I Sbjct: 540 NMLHHPQEVDGNKIGLLNVHKRLQLTYGKTSGLIIESAKGKGTCVRFTI 588 >Q5WIY4.1 Q5WIY4_BACSK Two-component sensor histidine kinase Length = 599 Score = 378 bits (971), Expect = e-103, Method: Compositional matrix adjust. Identities = 220/592 (37%), Positives = 327/592 (55%), Gaps = 4/592 (0%) Query: 22 FHWFVKL-MNDIKIRNKXXXXXXXXXXXXXXXXXXXXTFEMRTMAFDNALEQASTNVDRV 80 FH +V +N IKIR+K T E++ A +A EQA NV+RV Sbjct: 5 FHQYVSTKLNQIKIRDKLILMFLSSVVIPIAVVGLFLTNELKANAIKDAQEQADMNVERV 64 Query: 81 RKRTEEVIGVSQDISYRLNNDTRLKRLAVRKYESIYEVVKAYQDYTDVREYIRLYSEISN 140 ++R EV+ ++ L D RL L YE + V +AY+ Y D + + EI Sbjct: 65 KQRINEVLKGPIMVANHLQFDERLSELVNTDYEHSFSVFQAYRSYPDFAYHKGNHPEIET 124 Query: 141 IRLYTDNSSLLNNWELINPSPAIKESEWYQRAQRYEGLVGWEYIEDE-RDHHKYLSLVRK 199 IRLY DN +LLNNW I P + + WY A+ G W Y++DE + YLSL+++ Sbjct: 125 IRLYVDNPTLLNNWTFI-PVERSQMASWYTIAKADVGFYQWFYLQDETQGGGHYLSLMKR 183 Query: 200 IELEGSSKTGVLVINVNSNKLTSILNQESFDTMIVDDQNNIIASNRKEREGKTLADISFD 259 I G+LVI + + L +I+ QE+ T++VD+QN+II+S+ G+ L ++ Sbjct: 184 INFIEYGTFGLLVITIAPDLLETIMQQETHQTVVVDEQNSIISSSEPSFIGENLDELVVV 243 Query: 260 TKLLGRGSGSYEAVVEGEPSQIVIDELSPQASRNALRVVSVFSIDSIVKEPNRIIRLALS 319 T G YE GEP ++ L P+ S+N LR+VS+ + IV ++ + Sbjct: 244 TDRGEGKHGFYEGQANGEPIHMMETSLFPELSQNQLRIVSIIHTEDIVGAAKKLSYFGVL 303 Query: 320 VIAIXXXXXXXXXXXXXXXXXXXXXXXXKHINRVGTGDFDTSLQIDGKDEIALLARQFNS 379 V + + V G+ T + +DG DEI ++ Q N Sbjct: 304 VTGLGIAFSLFLIVWFSWGYVNRLSRLSATMKEVAQGNLTTKVALDGTDEIGQISLQLNK 363 Query: 380 MVRSIHDLMLEVQVSNEQNSLLQQKQNDIRFKMLASQINPHFLFNALESIRMEAHMKNQQ 439 M+ +++ + ++ +NEQ + L++KQN+++FKM+ASQ+NPHFLFN LE+IRM AHM N+ Sbjct: 364 MIDDLNESIAQLLEANEQKTALERKQNEMKFKMMASQMNPHFLFNTLEAIRMRAHMSNET 423 Query: 440 EIARVVRLLGQMMRSSLEVGRSKVTLKQELDMVRCYLEIQQFRYEERLKYHFIVDPAIES 499 +IA+ V+ LGQ++R SLEVG S + LK+EL+MVR YLEIQ FRY ERL Y I++ Sbjct: 424 DIAKAVKRLGQLLRKSLEVGSSMIPLKEELEMVRSYLEIQSFRYGERLTYDMDDAVTIDN 483 Query: 500 LSMPPLIIQPLVENAVIHGLDNTLEGAVVTVEIRYEQEHAVFTITDNGVGITQDRLEQVR 559 +++ PL IQPLVENAV HGL+ V + I+ ++ ++DNG+G+ R ++V+ Sbjct: 484 VAVIPLTIQPLVENAVSHGLEAKEADGYVNIRIKQAEDGTWIEVSDNGIGMGPQRQQEVQ 543 Query: 560 STLETQEEQEGARIGLRNVHDRLKLSYGEKYGLTIESHPDEGTRISFRIPME 611 + +E E+ RIGLRNVH RLK +YG GL I S EGT + F IP E Sbjct: 544 AMIEDPLEKPENRIGLRNVHQRLKQTYGTD-GLLISSSQGEGTTVRFLIPKE 594 >B8I617.1 B8I617_CLOCE Histidine kinase Length = 612 Score = 315 bits (808), Expect = 6e-84, Method: Compositional matrix adjust. Identities = 194/593 (32%), Positives = 308/593 (51%), Gaps = 14/593 (2%) Query: 30 NDIKIRNKXXXXXXXXXXXXXXXXXXXXTFEMRTMAFDNALEQASTNVDRVRKRTEEVIG 89 N+I+IR K T+ M + + +A T+ RVR R E++ Sbjct: 11 NNIRIRKKMIGIYAISVLLPVFFVSLYLTYSMSNAVYSRMVNEAKTDTVRVRDRVNELLY 70 Query: 90 VSQDISYRLNNDTRLKRLAVRKYESIYEVVKAYQDYTDVREYIRLYSEISNIRLYTDNSS 149 + +IS ++ D +LK + KY S E A + Y ++EYI+ YS+I I LY DNS+ Sbjct: 71 LMTNISDKIYFDKQLKNIISTKYSSFLEFNNACKSYPALKEYIQYYSQIEAITLYVDNST 130 Query: 150 LLNNWELINPSPAIKESEWYQRAQRYEGLVGWEYIEDERDHHKYLSLVRKIELEGSSKTG 209 + +N + + +++ +WY+ A R G + W+ + ++ YL+LVR+I ++ + Sbjct: 131 MWDNGFFVKTTDTVRKEDWYKAAVRSGGNMIWQCFYNNDNNSYYLALVRRIRIDDNGNYA 190 Query: 210 VLVINVNSNKLTSIL-NQESFDTMIVDDQNNIIASNRKEREGKTLADISFDTKLLGRGSG 268 V+V+ V+ + LTS++ N+++ M VD+ ++A +RK+ K D K L SG Sbjct: 191 VMVMRVSYSYLTSVIQNEKTTMLMTVDNDRIVLADDRKKLGTK------IDLKGLTAVSG 244 Query: 269 SYEAVV-----EGEPSQIVIDELSPQASRNALRVVSVFSIDSIVKEPNRIIRLALSVIAI 323 E + E IV D PQ +R+ ++++++ I ++ + + I Sbjct: 245 DSEQFLKDVSYENRKVFIVHDSFLPQKTRSTIQIINITPTSDITRQVIDTYTTGILIALI 304 Query: 324 XXXXXXXXXXXXXXXXXXXXXXXXKHINRVGTGDFDTSLQIDGKDEIALLARQFNSMVRS 383 I+R +GD D S I G DEIA L + M+ Sbjct: 305 SLVAPVMLMVLFTGNFSKRILFIRTQIHRAASGDLDISPGISGSDEIAELYKDLIKMIGD 364 Query: 384 IHDLMLEVQVSNEQNSLLQQKQNDIRFKMLASQINPHFLFNALESIRMEAHMKNQQEIAR 443 + L+ E Q L KQN+ +FKMLASQINPHFLFN LESIRM+A + Q+EIA Sbjct: 365 MKKLLQENYEHKLQQQKLLTKQNEAQFKMLASQINPHFLFNTLESIRMKAFVCGQREIAT 424 Query: 444 VVRLLGQMMRSSLEVGRSKVTLKQELDMVRCYLEIQQFRYEERLKYHFIVDPAIES--LS 501 V++LLG+ MRS LE+ + LK ELD VR YLEIQ+FR+ ER+ Y V I+ L Sbjct: 425 VIKLLGKSMRSLLELDDNPQPLKSELDFVRNYLEIQKFRFAERVDYTIDVQDGIDEKILK 484 Query: 502 MPPLIIQPLVENAVIHGLDNTLEGAVVTVEIRYEQEHAVFTITDNGVGITQDRLEQVRST 561 + PL+IQP+VENA +HGL+ + + + E+ + + D+G+G+ ++LE+V Sbjct: 485 VLPLLIQPIVENAFVHGLEQKEGHGRIDIIVNRYNENIMVIVKDDGLGMEAEKLEEVHCK 544 Query: 562 LETQEEQEGARIGLRNVHDRLKLSYGEKYGLTIESHPDEGTRISFRIPMEVAK 614 ++ + G IGL NV+ R+KL YGE YG+ ++S P GT + P + K Sbjct: 545 IKESGGKTGKSIGLSNVNQRIKLYYGESYGIRVDSSPGTGTTVWISFPEQCLK 597 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.317 0.134 0.369 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,028,442,469 Number of extensions: 114022273 Number of successful extensions: 409545 Number of sequences better than 1.0e-05: 2124 Number of HSP's gapped: 406753 Number of HSP's successfully gapped: 2124 Length of query: 614 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 472 Effective length of database: 1,722,912,073 Effective search space: 813214498456 Effective search space used: 813214498456 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 134 (56.2 bits)