BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0126.0020.p (607 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B1D501.1 B1D501_9BACL Signal transduction histidine kinase, LytS 422 e-116 B3K495.1 B3K495_9BACI Histidine kinase internal region 409 e-112 A9U718.1 A9U718_PHYPA Predicted protein 326 4e-87 A4XMI9.1 A4XMI9_CALS8 Integral membrane sensor signal transducti... 291 2e-76 A9KLC0.1 A9KLC0_CLOPH Histidine kinase internal region 229 4e-58 >B1D501.1 B1D501_9BACL Signal transduction histidine kinase, LytS Length = 633 Score = 422 bits (1084), Expect = e-116, Method: Compositional matrix adjust. Identities = 238/607 (39%), Positives = 355/607 (58%), Gaps = 6/607 (0%) Query: 1 LTYILVILIPTTVFSGYILGVNYQNSITSIINKNEYFLNTEKANILNNMEAMELTSQLAL 60 L+++ VI IP +FS Y L ++ + NE L EK NI NNME ME T QLAL Sbjct: 27 LSFVFVIFIPVILFSWYTLNEESAKAMEELTKNNENVLAIEKINIENNMELMEWTGQLAL 86 Query: 61 SDREVLDYMLSNRDFTAEELINFNTHSFHNLQYIMYNNPNISNLRFFTSNKYAREIWPII 120 S+RE+ +Y+ + A +++ +N QY ++NNP I+N+R FT N Y EIWP+I Sbjct: 87 SNREMNNYLQIEQIQDAAHVLHIKKDVVNNFQYFLFNNPRIANVRLFTDNLYVNEIWPVI 146 Query: 121 YNERRIAGENWANEFYAQPEAVWWTIYRGPEELRGSTEGERQDYLNFASLVREVKYPLDQ 180 E RI + W +E + W I + + E Q F + ++E KY ++ Sbjct: 147 LQESRIEDKPWHDEVVKRSGLPLWEIQE--DVVLTGVPSEPQPNEPFMTYLQEFKYADNR 204 Query: 181 -HLALLQVNMRLDVFFSNIYGNLQEASTQLLAIDRNSHLYYNGTSSFYEKIAPEDIRSEF 239 H +L+++M+L FFS + ++Q+ ++QL+ I RN +Y S + + + E + + Sbjct: 205 AHNGILEISMQLSDFFSQTFSSVQDNNSQLIVIARNGQVYSLEASPVFAQHSAEQLMNRV 264 Query: 240 ALHTQGSEGNFQFTHEGIPYLCLYTSIERXXXXXXXXXXXXXXYNDMNKTRLAIGGATLM 299 L + +F G YL T I +N +R+ + Sbjct: 265 KLTSNTDYETVKFKVSGQSYLAFQTYIPSIDLHLVNMVSLADTMEGINHSRVRYLVLISL 324 Query: 300 LVLILSLITYKLLSVILKRLHLLRDSMKKVRQGDFNVEIPQL-GGDEVGELGNHIRQMLS 358 LV L +++Y + + IL+RL +LR+SM++VR G+FNVE+P + G DEVGELG H R+++ Sbjct: 325 LVAFLVVLSYSMQAFILRRLKVLRESMQQVRSGNFNVELPPITGSDEVGELGFHYRELIL 384 Query: 359 KINELIAEAVNKQASSKEAELNSLKNQIDAHFLYNTLENLKMLAEIEGQLVISDTLTSLG 418 KINELI E + A+ KEAEL +LKNQID+HFLYNTLEN+KMLAEIEGQ +ISD +TSLG Sbjct: 385 KINELIQEQAARHAAGKEAELKALKNQIDSHFLYNTLENVKMLAEIEGQYLISDIMTSLG 444 Query: 419 AMLRYNLHWTTHYVRLYEEIQHIQNYIAVMNIRYGGKLELRLDVRQQYRQQEILKMSLQP 478 M+RY++ W +V L +EI+ +Q+YI+VMNIRY G+L+LRL + Q+ +QE LKMSLQP Sbjct: 445 GMMRYSMEWKQDHVMLSDEIKQVQHYISVMNIRYDGRLDLRLSIAQECLKQETLKMSLQP 504 Query: 479 IVENALKYGMNAPGLRKRGLMIVIHAYEQDDFMYIEIRDNGAGISAERLYNINLALQLDP 538 +VENA+K+GM+ L++ I A + IEI D+G GI L +N L+++ Sbjct: 505 VVENAIKHGMSRMHSSDGNLVVAISADRRGHACVIEITDSGCGIPEGMLNLLNQMLRMEE 564 Query: 539 AAAAMYAPPVNGDSAYDTSGSGIGLRNVHLRIQLHYGKTSGLWLESVEGEYTKVTIKVPY 598 +A V D+ +GIGLRNV R+ + YG G+ +ES EG YT++ + +PY Sbjct: 565 SAYQDVRQLVVRKDNQDS--NGIGLRNVDQRLVMSYGPEYGIRIESQEGSYTRIIMTLPY 622 Query: 599 LILSGGL 605 + GG+ Sbjct: 623 RLTGGGV 629 >B3K495.1 B3K495_9BACI Histidine kinase internal region Length = 667 Score = 409 bits (1051), Expect = e-112, Method: Compositional matrix adjust. Identities = 241/615 (39%), Positives = 364/615 (59%), Gaps = 24/615 (3%) Query: 2 TYILVILIPTTVFSGYILGVNYQNSITSIINKNEYFLNTEKANILNNMEAMELTSQLALS 61 YIL++LIP+ + S Y I+ +N+N + L EK N+LN +EA+E+ +QLA+S Sbjct: 54 AYILILLIPSMIVSNYFFKQIRDTYISDALNQNSFLLEIEKMNMLNQIEAIEMAAQLAIS 113 Query: 62 DREVLDYMLSNRDFTAEELINFNTHSFHNLQYIMYNNPNISNLRFFTSNKYAREIWPIIY 121 D + DY+ N + LI+ F ++Q I NNPNI++LR +T+N Y E+WPII+ Sbjct: 114 DDGIKDYLRINEEPEPAWLIDLAWGPFKDIQRIQTNNPNITHLRLYTNNSYVTEMWPIIF 173 Query: 122 NERRIAGENWANEFYAQPEAVWWTI-YRGPEELR--GSTEGERQDYLNFASLVREVKYPL 178 +E+RIA E W + W +R P+ L+ + E Q + SL+R+V Sbjct: 174 HEKRIASEPWFPKVKELDGGEMWVFNHRDPDILQRYAADVSEEQPKV---SLIRQVHN-- 228 Query: 179 DQHLALLQVNMRLDVFFSNIYGNLQEASTQLLAIDRNSHLYYNGTSSFYEKIAPEDIRSE 238 + ++QV+M L F + + + S+Q++ +D+ L+ + + SF + E +R E Sbjct: 229 GNYSGVIQVDMLLKYFAPKTFAGIVDNSSQMVIVDQEGKLFMDRSQSFM--TSHEGLRDE 286 Query: 239 ----FA---LHTQGSEGNF--QFTHEGIPYLCLYTSIERXXXXXXXXXXXXXXYNDMNKT 289 FA L T SE +F+ +G +L + T +ER N+++K Sbjct: 287 VELQFAKLKLQTGDSEETMHARFSLDGSSFLLIATPMERLHAHVLNVVSLEGALNNVSKA 346 Query: 290 RLAIGGATLMLVLILSLITYKLLSVILKRLHLLRDSMKKVRQGDFNVEIPQLGGDEVGEL 349 + I A ++L+++LS+ITY L S+ILK L L ++MK+VR+G+ I GG EVGEL Sbjct: 347 QGQIIAANVVLIILLSIITYYLNSIILKSLRRLTETMKRVRKGEVTAAIAIRGGGEVGEL 406 Query: 350 GNHIRQMLSKINELIAEAVNKQASSKEAELNSLKNQIDAHFLYNTLENLKMLAEIEGQLV 409 +H +++ INELIA+ V KQA +KEAEL +L +QID+HFLYNTLEN+KMLAEIEGQ Sbjct: 407 AHHFNKLIRTINELIAQGVRKQAVTKEAELRTLHSQIDSHFLYNTLENIKMLAEIEGQRT 466 Query: 410 ISDTLTSLGAMLRYNLHWTTHYVRLYEEIQHIQNYIAVMNIRYGGKLELRLDVRQQYRQQ 469 ISD LTSLG M+RYN W+ YV+L +EI+HI+NYI VMNIR+ + L L++ ++ + Sbjct: 467 ISDALTSLGGMMRYNFKWSGEYVKLRDEIRHIRNYIDVMNIRFDEPIRLELNIPSEFMEL 526 Query: 470 EILKMSLQPIVENALKYGMNAPGLRKRGLMIVIHAYEQDDFMYIEIRDNGAGISAERLYN 529 E+LKMSLQPIVENA+K+ +++ + I + A+E+D + I + DNG GI RL Sbjct: 527 EVLKMSLQPIVENAVKHAWPEFPDQEKQIKIDVIAWEEDQ-ITINVTDNGIGIEPYRLGR 585 Query: 530 INLALQLDPAAAAMYAPPVNGDSAYDTSGSGIGLRNVHLRIQLHYGKTSGLWLESVEGEY 589 + L+ A P GIGLRNVH RI+L YG G+ L+S +G++ Sbjct: 586 LGEILR----TADDEELPSGDYGRGGVQAGGIGLRNVHQRIRLFYGNEYGIELKSEKGKF 641 Query: 590 TKVTIKVPYLILSGG 604 T+VT+ P ++L+GG Sbjct: 642 TQVTMTFPKVLLTGG 656 >A9U718.1 A9U718_PHYPA Predicted protein Length = 450 Score = 326 bits (836), Expect = 4e-87, Method: Compositional matrix adjust. Identities = 180/438 (41%), Positives = 271/438 (61%), Gaps = 12/438 (2%) Query: 173 EVKYPLDQ-HLALLQVNMRLDVFFSNIYGNLQEASTQLLAIDRNSHLYYNGTSSFYEKIA 231 E KYP + H +L+++M+L FFS + ++Q+ ++QL+ + RN ++ SS +++ Sbjct: 19 EFKYPDNTTHNGILEISMQLSDFFSQTFSSVQDKNSQLIVVARNGQVFSLKDSSVFKQNG 78 Query: 232 PEDIRSEFALHTQGSEGNFQFTHEGIPYLCLYTSIERXXXXXXXXXXXXXXYNDMNKTRL 291 E++ S L + +F G YL L + I +N +R+ Sbjct: 79 AEELISSIKLTSHTDYETVRFKVNGHSYLALQSYIPSIDVHLVNMASLEETMEGINHSRV 138 Query: 292 AIGGATLMLVLILSLITYKLLSVILKRLHLLRDSMKKVRQGDFNVEIPQLGG-DEVGELG 350 +L L L++Y + ++IL+RL LR+SM++VR G+FNVE+P + G DEVGELG Sbjct: 139 RYIVLVSLLAAFLVLLSYSMQAIILRRLKALRESMQQVRNGNFNVELPPITGTDEVGELG 198 Query: 351 NHIRQMLSKINELIAEAVNKQASSKEAELNSLKNQIDAHFLYNTLENLKMLAEIEGQLVI 410 H R+++ KINELI + +QA+ KEAEL +LKNQID+HFLYNTLEN+KMLAEIEGQ +I Sbjct: 199 FHYRKLILKINELIQDQAARQAAGKEAELRALKNQIDSHFLYNTLENVKMLAEIEGQYLI 258 Query: 411 SDTLTSLGAMLRYNLHWTTHYVRLYEEIQHIQNYIAVMNIRYGGKLELRLDVRQQYRQQE 470 SD +TSLG M+RY++ W +V L +EIQ +Q+Y++VMNIRY G+L+L+L + + +QE Sbjct: 259 SDIMTSLGGMMRYSMEWRQDHVMLSDEIQQVQHYVSVMNIRYDGRLDLQLSIEPECLKQE 318 Query: 471 ILKMSLQPIVENALKYGMNAPGLRKRGLMIVIHAYEQDDFMYIEIRDNGAGISAERLYNI 530 LKMSLQP+VENA+K+GM+ + L+I I A + IEI D+G GI E L + Sbjct: 319 SLKMSLQPVVENAIKHGMSRMHSKDGNLLITISAVRRGQACVIEITDSGRGIPDETLGLL 378 Query: 531 NLALQLDPAA----AAMYAPPVNGDSAYDTSGSGIGLRNVHLRIQLHYGKTSGLWLESVE 586 N L+++ A ++ N D G+GIGLRNV R+ + YG G+ +ES E Sbjct: 379 NQMLRMEEHAYQEVRQLFVRKENED------GNGIGLRNVDQRLVMSYGVEYGIRIESQE 432 Query: 587 GEYTKVTIKVPYLILSGG 604 G YT++ + +PY ++ GG Sbjct: 433 GSYTRIIMTLPYRVMGGG 450 >A4XMI9.1 A4XMI9_CALS8 Integral membrane sensor signal transduction histidine kinase Length = 614 Score = 291 bits (744), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 191/620 (30%), Positives = 328/620 (52%), Gaps = 59/620 (9%) Query: 1 LTYILVILIPTTVFSGYILGVNYQNSITSIINKNEYFLNTE------KANILNNMEAMEL 54 +YIL++ IP + IL +N ++ + K EY N K++I+ N+E Sbjct: 26 FSYILIVAIPIS-----ILQINAFQNVKDMTEK-EYINNIAFEVEKLKSDIVKNVEQYVK 79 Query: 55 TSQLALSDREVLDYMLSNRDFTAEELINFNTHSFHNLQYIMYNNPNISNLRFFTSNKYAR 114 +Q L++++ +D++ ++ + EE+ +F + ++Y+ Y N NI+ +RFFT+N + Sbjct: 80 ATQFILNNQDFIDFVSIYQERSPEEIFSFKVNVLDEIEYLQYVNFNINRIRFFTNNVFLP 139 Query: 115 EIWPIIYNERRIAGENWANEFYAQPEAV-WWTIYR----GPEELRGSTEGERQDYLNFAS 169 E WP++Y RI + + +F PE + W I GP L T+ S Sbjct: 140 ETWPVLYQLDRIKNQKYIADFLDNPEKISLWKINNTDNLGPP-LNNDTK--------VVS 190 Query: 170 LVREVKYPLDQHLALLQVNMRLDVFFSNIYGNLQEASTQLLAIDRNSHLYYNGTSSFYEK 229 +V + + +++VNM D FF+N S ++AI ++ + YN S + + Sbjct: 191 YYTKVIDSVGNLVGIIEVNMLTDEFFANELTRSNRNSV-MVAITKDGEIVYNHQLSDFLR 249 Query: 230 IAPEDIRS--EFALHTQGSEGNFQFTHEGIPYLCL--------YTSIERXXXXXXXXXXX 279 D++ EF + N E I Y L YT + Sbjct: 250 TLKIDLKDFKEFLIKKTDVTKN-----EEIVYFRLGRTSAAFVYTYVPMLGMYLYKVVLF 304 Query: 280 XXXYNDMNKTRLAIGGATLMLVLILSLITYKLLSVILKRLHLLRDSMKKVRQGDFNVEIP 339 +N+ + + ++L+ I S + + ++S+IL++L + +M+KV GDF+V+I Sbjct: 305 DALTQKINQLTIKMLWQVVVLMFISSALIFVIISLILRKLKDIISTMRKVENGDFDVKIE 364 Query: 340 QLGGDEVGELGNHIRQMLSKINELIAEAVNKQASSKEAELNSLKNQIDAHFLYNTLENLK 399 G DE+ EL H ++M+ +I LI + V K+ + K+A++ +L++QI+AHF+YN LEN+K Sbjct: 365 IKGDDEIDELAFHFQKMIERIKVLIVDTVKKELAQKDAQIKALQSQINAHFIYNVLENIK 424 Query: 400 MLAEIEGQLVISDTLTSLGAMLRYNLHWTTHYVRLYEEIQHIQNYIAVMNIRYGGKLELR 459 M+AE + +SD +T LG M+RYN+ W +V LY+E+++I+NY+A+MN+R+ +++L Sbjct: 425 MMAECKEDYEVSDAITKLGKMMRYNMSWKRKFVTLYDELENIKNYVALMNLRFDKEIKLM 484 Query: 460 LDV-RQQYRQQEILKMSLQPIVENALKYGMNAPGLRKRGLMIVIHAYEQDDFMYIEIRDN 518 +++ ++ E+ K+ LQPI+EN++ YG+ G G I I A +F+ I I D+ Sbjct: 485 INIYNEEILNYEVPKLILQPIIENSITYGIEPKG---EGGSIFIDANVIGEFLVITIVDD 541 Query: 519 GAGISAERLYNINLALQLDPAAAAMYAPPVNGDSAYDTSGSGIGLRNVHLRIQLHYGKTS 578 G GI E+L I A++ G A G GI L+NV+ RI+L YGK Sbjct: 542 GKGIEEEKLRQIQEAIE-------------KGIDAECYHGQGIALKNVNERIKLTYGKAY 588 Query: 579 GLWLESVEGEYTKVTIKVPY 598 GL +ES E E+TKVTI +P+ Sbjct: 589 GLKIESKENEFTKVTITLPF 608 >A9KLC0.1 A9KLC0_CLOPH Histidine kinase internal region Length = 599 Score = 229 bits (585), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 165/616 (26%), Positives = 311/616 (50%), Gaps = 50/616 (8%) Query: 4 ILVILIPTTVFSGYILGVN-YQNSITSIINKN----EYFLNTEKANILNNMEAMELTSQL 58 I +++I T V IL V +QN S+I + E +N +I N+E +++Q+ Sbjct: 17 ITILIIGTIVIPMVILSVLLFQNMRESVIKEKVKNVEISINQSYNHIQKNVELCHMSTQV 76 Query: 59 ALSDREVLDYML---SNRDFTAEELINFNTHSFHNLQYIMYNNPNISNLRFFTSNKYARE 115 L+ D ++ ++ D E+I F+ + N++ ++ +NP + +R + K E Sbjct: 77 ILNSEGFWDKLIEFQNSEDVDKNEIIKFSKNDVRNIERLVNSNPYLYQIRIYIGTKKVPE 136 Query: 116 IWPIIYNERRIAGENWANEFYAQPEAVWWTIYRGPEELRGSTEGERQDYLNFASLVREVK 175 + P++Y R+ +W +E ++W + ++ + V K Sbjct: 137 MMPVLYYMDRLEVFDWYDE--NDTRKIFWNFDYDGTIFPYYVLKPSKHIVSLTTRVIATK 194 Query: 176 YPLDQHLALLQVNMRLDVFFSNIYGNLQEASTQLLAIDRNSHLYYNGTSSFYEKIAPEDI 235 +D AL++V ++DV F +IY +E T + + ++ Y G S+ E + Sbjct: 195 KKVD---ALIEVATKMDVIFPDIYEANEEQWTCFVD-EHGTYFYGEGDSNQKWLEFAEGV 250 Query: 236 RSEFALHTQGSE-GNFQFTHEGIPYLCLYTSIERXXXXXXXXXXXXXXYNDMNKTR---- 290 T+ S N E P + Y +E+ + D+N R Sbjct: 251 FKTIQKDTKESYYHNMYLDKE--PVVVGYIPLEQFNGHLLKIVSLKKAFRDINDKRNVFL 308 Query: 291 LAIGGATLMLVLILSLITYKLLSVILKRLHLLRDSMKKVRQGDFNVEIPQLGGDEVGELG 350 + GA +L++ + L+ ++L+ + + ++ KV++GD + +P +E+G+L Sbjct: 309 VGFSGAVAILIVAANF----LVKLVLRDFYRVIHTVTKVKEGDLAIRVPVCSSNEIGQLS 364 Query: 351 NHIRQMLSKINELIAEAVNKQASSKEAELNSLKNQIDAHFLYNTLENLKMLAEIEGQLVI 410 I M+ I +L+ + ++ K++E+ +L+NQI+AHF+YN LE++KM+AEIE + I Sbjct: 365 GQINDMMDTITDLMEGQLKRELLVKDSEIRALQNQINAHFIYNVLESIKMMAEIEERYDI 424 Query: 411 SDTLTSLGAMLRYNLHWTTHYVRLYEEIQHIQNYIAVMNIRYGGKLELRLDVRQQYRQQE 470 SD +TSLG +LRY++ W + V + EE+ +I+NY+A++N+R+ ++ L +++ QE Sbjct: 425 SDAVTSLGKLLRYSMKWVSKNVTVREEVDYIKNYLALINLRFDYEIYLSINMPDIIWSQE 484 Query: 471 ILKMSLQPIVENALKYGMNA----PGLRKRGLMIVIHAYEQDDFMYIEIRDNGAGISAER 526 I KMSLQPI+ENA+ +G+ + +G++ +D+ IEI D+G G++ E Sbjct: 485 IPKMSLQPIIENAIYHGIEEIAEDTSIYMKGILF-------EDYCTIEITDSGKGMTEEE 537 Query: 527 LYNINLALQLDPAAAAMYAPPVNGDSAYDTSGSGIGLRNVHLRIQLHYGKTSGLWLESVE 586 + + + + + +SG+GIGL+NV RI++ +G+ G+ + S + Sbjct: 538 VRKLQRKISGEIETSG-------------SSGNGIGLKNVQDRIKISFGEPYGISVASRK 584 Query: 587 GEYTKVTIKVPYLILS 602 YTKV +K+P LILS Sbjct: 585 DCYTKVIVKIP-LILS 599 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.319 0.136 0.390 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,394,845,873 Number of extensions: 139075151 Number of successful extensions: 479670 Number of sequences better than 1.0e-05: 1984 Number of HSP's gapped: 476669 Number of HSP's successfully gapped: 1987 Length of query: 607 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 465 Effective length of database: 1,722,912,073 Effective search space: 801154113945 Effective search space used: 801154113945 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 134 (56.2 bits)