BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0078.0008.p (608 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KGE0.1 B3KGE0_9BACI Histidine kinase internal region 617 e-175 B1D5E7.1 B1D5E7_9BACL Integral membrane sensor signal transducti... 587 e-165 B3K8I6.1 B3K8I6_9BACI Histidine kinase internal region 330 3e-88 B1RLM8.1 B1RLM8_CLOPE Sensor histidine kinase 267 3e-69 Q8XIM7.1 Q8XIM7_CLOPE Two-component sensor histidine kinase 266 4e-69 >B3KGE0.1 B3KGE0_9BACI Histidine kinase internal region Length = 607 Score = 617 bits (1592), Expect = e-175, Method: Compositional matrix adjust. Identities = 296/600 (49%), Positives = 424/600 (70%), Gaps = 10/600 (1%) Query: 4 PGKWYKKHLKNNLFMKIILIFSIIAVVTTITFSYLMFLLMSQSVVQRQLEIQKRTVESVN 63 P + Y K++KNN+F K++L+ ++IAVV +T S+LM+ + QS V+ +L+IQ+ VE V Sbjct: 3 PARLYLKYIKNNMFTKMLLLIALIAVVIIVTLSFLMYYFLFQSAVRSELDIQRSAVERVE 62 Query: 64 DYMQHKYNAVQTMMRDVYRDSELTANTSYLLEHPYQDYVTYRLDRYLNETSTTTDSV-QF 122 ++ KY Q+ + D+YR+S L +TSY L + + +Y+ R++R + +DSV + Sbjct: 63 RHLNQKYENAQSYVNDLYRNSSLGIDTSYFLMNSFNEYMAKRMNRIAGGGQSNSDSVVAY 122 Query: 123 FRNQLEDDPDIRRLLLYSSVKQQLYVFNDRENFNIISTNAAHSLVPDALYLEEASSVTLP 182 F+ +L+DDPDI ++LYS+ KQ +YV+ + NA HS +PD + LE + SVTLP Sbjct: 123 FKQRLDDDPDIENIMLYSAEKQYVYVYKQGSMTRLYQANATHSYIPDVMALE-SQSVTLP 181 Query: 183 NIWVRKTISLSDSPMFSIRVPINDKQSLRNIGQLLVFYDADHIWKSMGDYKDDFKGDIIV 242 N+W+RK P+FSIR PIND + +N+GQLL+ Y + + + + D KG ++V Sbjct: 182 NLWIRKLAGDVTLPLFSIRSPINDMTTYKNLGQLLILYRTEALDAVLNNSDDSLKGSVLV 241 Query: 243 LSADNDVLFDSSGTFYGKKYPYPEQI----EAIYADGEKVNGMLITKLTHTQGGFTVLSA 298 LS D V+FDSSG +YG+KYPY +Q+ E + D E IT H Q G+TV+ Sbjct: 242 LSGDGRVMFDSSGKYYGEKYPYADQLLNSKETVTLDEES----YITTAAHNQAGYTVVGI 297 Query: 299 VPERELAATYRGLRNMIVIICLICILFAVITPSLFISNFATRAHNIIRFTRKVKNGDLDA 358 P+RE+A ++ GL++ I+I L+CI+ AV PSL I N++ R NIIRF RKV+ G+ A Sbjct: 298 TPKREIAESFHGLQSTIIIAALLCIVIAVSIPSLMIVNYSRRTDNIIRFMRKVEKGEFVA 357 Query: 359 RIADVKEDELGQISKSFNDMLDELNLYIDRVFKAEIKQKHSEISALEARVNPHFLYNTLE 418 R+ D K+D+LGQI+ SFN+MLDEL+ YID+V+KAEI QK++E+SAL+AR+NPHFLYNTLE Sbjct: 358 RMQDTKDDQLGQIAGSFNEMLDELSRYIDKVYKAEINQKNAELSALQARINPHFLYNTLE 417 Query: 419 VIRMRAISQGAADVGEMIYSLSVLFKSYVHPKAKHTMKDELEACRLYLELFRIRYKDKFS 478 VIRMRA+SQGA DVG+MIYSLS+LFK+ V K+ +T+KDELEACRLYLELFRIRYKDK+ Sbjct: 418 VIRMRALSQGAQDVGDMIYSLSMLFKNIVQHKSHYTLKDELEACRLYLELFRIRYKDKYI 477 Query: 479 YELHCPKELEGRVVLKMSLQPIVENYILHGMRTDRSDNHISIHLAKEGVILRAVVTDNGR 538 Y++HC +++ ++KMSLQP++ENYI+HG+R+D+ DN ++I+ +E + + DNG+ Sbjct: 478 YKMHCDDQIKHVPMIKMSLQPLIENYIVHGLRSDQDDNWLTINATQEDDEVHIEIKDNGK 537 Query: 539 GIKQERLEQIQHDLLDKDSSSESFGLRSINERMKLLYGEPHGLAVDSEEGKGTTVTVCFP 598 GI +RLE I+ L +SS ESFGLRS+NER+KL YG +G+ + SE G GTTVTV FP Sbjct: 538 GIPPQRLEDIKSRLDVAESSGESFGLRSVNERLKLTYGSSYGMDIQSEPGNGTTVTVKFP 597 >B1D5E7.1 B1D5E7_9BACL Integral membrane sensor signal transduction histidine kinase Length = 609 Score = 587 bits (1514), Expect = e-165, Method: Compositional matrix adjust. Identities = 285/603 (47%), Positives = 419/603 (69%), Gaps = 3/603 (0%) Query: 6 KWYKKHLKNNLFMKIILIFSIIAVVTTITFSYLMFLLMSQSVVQRQLEIQKRTVESVNDY 65 K Y+ +++NNLF+K+IL+F++I +T IT SYL+F L+S S+V +L QK+ +E VN Y Sbjct: 5 KIYRNYIQNNLFVKVILVFALIVNLTIITLSYLLFGLISDSIVNSELNNQKQAMERVNRY 64 Query: 66 MQHKYNAVQTMMRDVYRDSELTANTSYLLEHPYQDYVTYRLDR-YLNETSTTTDSVQFFR 124 M+ KY+ VQ ++D+YR+S L +N SY L H Y +Y Y LD+ Y + D + + Sbjct: 65 MEQKYDWVQNTVQDIYRNSLLASNASYFLRHSYSEYAQYMLDQNYAGGNESAVDILSYLA 124 Query: 125 NQLEDDPDIRRLLLYSSVKQQLYVFNDRENFNIISTNAAHSLVPDALYLEEASSVTLPNI 184 ++++ DPDI+ +LLYS+ QQLY FN + TN S +P+ + E ++ T PNI Sbjct: 125 DRMDADPDIQNILLYSTDMQQLYAFNRNGPRRLYKTNPTRSYIPEIMAAEGPAAAT-PNI 183 Query: 185 WVRKTISLSDSPMFSIRVPINDKQSLRNIGQLLVFYDADHIWKSMGDYKDDFKGDIIVLS 244 W+R I +S ++S+RV +NDK +L+NIGQLLV++D+ + +S+ + KG+I+VLS Sbjct: 184 WIRGLIGQWNSQLYSMRVQVNDKNTLKNIGQLLVYFDSGMVNRSLDQQRTPLKGEILVLS 243 Query: 245 ADNDVLFDSSGTFYGKKYPYPEQIEAIYADGEKVNGMLITKLTHTQGGFTVLSAVPEREL 304 D VL DS+ +YG+ +PY +QI ++ G I+ LT + G+ V+ P+ + Sbjct: 244 QDGQVLSDSANRYYGQIFPYMKQIGSLKETGMLDEPSYISTLTQNKAGYFVVGITPKSAM 303 Query: 305 AATYRGLRNMIVIICLICILFAVITPSLFISNFATRAHNIIRFTRKVKNGDLDARIADVK 364 A Y GL+ I++I ICI+ AVI PS+ I N + R + I+ F RKV+ G+L AR+ D + Sbjct: 304 AEAYAGLKRTIILISSICIVVAVIIPSIVIVNISRRTNRIVHFMRKVEGGNLTARLQDAR 363 Query: 365 EDELGQISKSFNDMLDELNLYIDRVFKAEIKQKHSEISALEARVNPHFLYNTLEVIRMRA 424 EDELGQIS+SFN+MLDEL +IDR +KAE++ K +E++AL+AR+NPHFLYNTLEVIRMRA Sbjct: 364 EDELGQISQSFNEMLDELGRHIDREYKAELRHKQTELAALQARINPHFLYNTLEVIRMRA 423 Query: 425 ISQGAADVGEMIYSLSVLFKSYVHPKAKHTMKDELEACRLYLELFRIRYKDKFSYELHCP 484 +SQGA DVGEMIYSL+VLF++ V KA++T+ +ELE CRLYLELFRIRYKDKF+YE+ C Sbjct: 424 MSQGAVDVGEMIYSLAVLFRNSVSAKAENTLGEELEMCRLYLELFRIRYKDKFAYEVECE 483 Query: 485 KELEGRVVLKMSLQPIVENYILHGMRTDRSDNHISIHLAKEGVILRAVVTDNGRGIKQER 544 +EL V K+ LQPIVENYI+HGM + R +N ++I A+E ++R + DNG+GI E+ Sbjct: 484 EELLRVPVAKLLLQPIVENYIVHGMDSRRKNNRLTIEAAQEHGLIRVRIRDNGKGIDPEQ 543 Query: 545 LEQIQHDL-LDKDSSSESFGLRSINERMKLLYGEPHGLAVDSEEGKGTTVTVCFPDLGEE 603 L I L + + +SFGLRS++ER++L++G +GL+++S GKGT+VTV +P ++ Sbjct: 544 LAHIMRRLKMPETEEQQSFGLRSVHERIELVHGPGYGLSIESTPGKGTSVTVIWPAAEQQ 603 Query: 604 EPT 606 E T Sbjct: 604 EET 606 >B3K8I6.1 B3K8I6_9BACI Histidine kinase internal region Length = 635 Score = 330 bits (845), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 201/613 (32%), Positives = 339/613 (55%), Gaps = 20/613 (3%) Query: 6 KWYKKHLKNNLFMKIILIFSIIAVVTTITFSYLMFLLMSQSVVQRQLEIQKRTVESVNDY 65 ++Y HLK +F KI++++S + +V + L++ +Q +++ Q + ++ +N Y Sbjct: 31 QFYLNHLKRKMFNKIVVLYSAVMIVLFAIAATLVYQYQTQRILREQTDANLKSAHVLNIY 90 Query: 66 MQHKYNAVQTMMRDVYRDSELTANTSYLLEHPYQDYVTYRLDRYLNETSTTTDSVQFF-- 123 + +Y ++Q + + +Y D+ L+ Y L + Y+ Y+ YRLD Y T T ++ F Sbjct: 91 LSRQYESIQNIFQQIYGDATLSDELIYFLNNEYESYLKYRLDLY---TKTGEQRLRSFNT 147 Query: 124 --RNQLEDDPDIRRLLLYSSVKQQLYVFNDRENFNIISTNAAHSLVPDALYLEEASSV-T 180 +N LE +P + + +YS Y+ R N + + + + S + E S T Sbjct: 148 LLKNYLEQEPSAKSVSIYS-YPNDFYMHISRTNQQLNNESGSKSKWENWFARREQHSWDT 206 Query: 181 LPNIWVRKTISLSDSPMFSIRVPINDKQSLRNIGQLLVFYDADHIWKSMGDYKDDFKGDI 240 +P + +++ S + +S + D +L +G L V +DA I + + + KG I Sbjct: 207 MPLNELSGSVAGSSARSYSYSRELKDPWTLERVGMLNVEFDARQI-STWLESRASVKGRI 265 Query: 241 IVLSADNDVLFDSSGTFYGKKYPYPEQIEAIYADGEKVNGMLITKLTHTQGGFTVLSAVP 300 +VL+A V++DS +YG+ YPY + E E + L G +V+ V Sbjct: 266 MVLNAQGTVIYDSEDVYYGQTYPYHLEPEKAGDWVELDEPSKVNMLNVGNAGLSVVGIVS 325 Query: 301 ERELAATYRGLRNMIVIICLICILFAVITPSLFISNFATRAHNIIRFTRKVKNGDLDARI 360 + + LR ++++ L+ + + + F+ + IIR ++ GDL RI Sbjct: 326 KSSIEENTESLRTGLILVTLVFMAASFAITFTIVRKFSKKVQRIIRSMNRIGEGDLSTRI 385 Query: 361 ADVKEDELGQISKSFNDMLDELNLYIDRVFKAEIKQKHSEISALEARVNPHFLYNTLEVI 420 EDEL QIS+ FNDM D L YID+++ +EIKQK++E+ AL++++NPHFLYNTLE I Sbjct: 386 QMSGEDELQQISRRFNDMGDRLEQYIDKMYTSEIKQKNAELVALQSQINPHFLYNTLESI 445 Query: 421 RMRAISQGAADVGEMIYSLSVLFKSYVHPKAKHTMKDELEACRLYLELFRIRYKDKFSYE 480 RM+A GA +VG+MIYSLSV+FK+ V T+++E++ C +YL+LFRIRY+ + E Sbjct: 446 RMKAYFVGAKEVGQMIYSLSVMFKNMVKKSTMVTVEEEIDMCSVYLDLFRIRYEGRLETE 505 Query: 481 LHCPKELEGRVVLKMSLQPIVENYILHGMRTDRSDNHISI--HLAKEGVILRAVVTDNGR 538 + E++ ++K+ +QPIVENYI+HG R +N IS+ H ++ V++ V+DNG Sbjct: 506 IEVDPEIQNLSIIKLLVQPIVENYIVHGFRPLEDNNKISVRAHGTEDRVVI--TVSDNGT 563 Query: 539 GIKQERLEQIQHDLLDK-----DSSSESFGLRSINERMKLLYGEPHGLAVDSEEGKGTTV 593 GI +++L QI+ LDK D S GL +++ER+ L YG +G+ + S EG+GT V Sbjct: 564 GIPEDKLIQIRQT-LDKVLQPPDKGYRSIGLMNVHERIVLNYGSDYGVTICSTEGRGTEV 622 Query: 594 TVCFPDLGEEEPT 606 + P L + E T Sbjct: 623 RMEIPKLRKGETT 635 >B1RLM8.1 B1RLM8_CLOPE Sensor histidine kinase Length = 578 Score = 267 bits (682), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 175/594 (29%), Positives = 321/594 (54%), Gaps = 27/594 (4%) Query: 10 KHLKNNLFMKIILIFSIIAVVTTITFSYLMFLLMSQSVVQRQ-LEIQKRTVESVNDYMQH 68 K K+NL+ ++ + ++I+ +++ ++ + FL + ++R L + + ++ VN+ +++ Sbjct: 2 KFSKSNLYKRLFITYTIV-ILSVVSILCIYFLSKTSEEIKRNNLYLNDKILQDVNETLEY 60 Query: 69 KYNAVQTMMRDVYRDSELTANTSYLLEHPYQDYVTYRLDRYLNETSTTTDSVQ-FFRNQL 127 + + +M +Y D + L DY+ +LD Y + ++ F ++ Sbjct: 61 NSSTSRRIMNMLYEDDFRLNDVIKYLNSDLVDYIKGKLDYYSASDKLYYNGIESFVKSSF 120 Query: 128 EDDPDIRRLLLYSSVKQQLYVFNDRENFNIISTNAAHSLVPDALYLEEASSVTLPNIWVR 187 + + ++ + S + ++ VFN + N+ L D +E A I+ + Sbjct: 121 QLNNFLKSISFISYSRNEISVFNRKGEIKTYPFNSNELL--DKKDIEYA-------IYNK 171 Query: 188 KTISLSDSPMFSIRVPINDKQSLRNIGQLLVFYDADHIWKSMGDYKDDFKGDIIVLSADN 247 IS+ + I D SL+ G L+ YD I + YKD ++++L+ + Sbjct: 172 NEISIINE--------IRDAASLKPEGMLMTTYDVGVISDVIKKYKDT-NSEVLILNKEG 222 Query: 248 DVLFDSSGTFYGKKYPYPEQIEAIYADGEKVNGMLITKLTHTQGGFTVLSAVPERELAAT 307 VL+DS + + YPY ++++ + + + L G ++S V + AT Sbjct: 223 MVLYDSENKYDYEYYPYFDKLKVGRHEILLEDSYYVDILPDNNG---LMSVVRIKVSNAT 279 Query: 308 YRGLRNMIVIICLICILFAVITPSLFIS--NFATRAHNIIRFTRKVKNGDLDARIADVKE 365 L + + LF + L+I N ++R +++ KV+ GD+D I K+ Sbjct: 280 KVPLLFKVSAFLVSLFLFIIAECVLYIKFKNLSSRMDSLVLAMEKVEKGDIDVHIPLSKD 339 Query: 366 -DELGQISKSFNDMLDELNLYIDRVFKAEIKQKHSEISALEARVNPHFLYNTLEVIRMRA 424 DE+ I+ +FN M ++LN +I + + AE++Q+ +EI AL+ ++NPHFLYNTLE IRM+A Sbjct: 340 RDEITFIADNFNKMCEKLNDHIRKSYLAELRQREAEIVALQNQINPHFLYNTLESIRMKA 399 Query: 425 ISQGAADVGEMIYSLSVLFKSYVHPKAKHTMKDELEACRLYLELFRIRYKDKFSYELHCP 484 I G +VG+M+YSL+ LF+S V ++ E++ C YLELF+ RY +KF +++ C Sbjct: 400 ICNGDKEVGKMLYSLAFLFRSQVKGNLIVSIDQEIKYCNKYLELFKFRYDEKFKFKIECE 459 Query: 485 KELEGRVVLKMSLQPIVENYILHGMRTDRSDNHISIHLAKEGVILRAVVTDNGRGIKQER 544 ++L + ++K +LQP++ENY +HG+R +R DN + I++ K + V DNGRGI +E+ Sbjct: 460 EDLYDKGIVKFTLQPLIENYFVHGIRLERDDNELKIYIYKHLEDIVVEVIDNGRGIPKEK 519 Query: 545 LEQIQHDLLDKDSSSESFGLRSINERMKLLYGEPHGLAVDSEEGKGTTVTVCFP 598 L+ I + + D S +S G+ +++ER+K+ YGEP+GL V SEE KGT + + FP Sbjct: 520 LDDINRKIRECDHSGKSIGMLNVHERIKIKYGEPYGLTVTSEENKGTNMILKFP 573 >Q8XIM7.1 Q8XIM7_CLOPE Two-component sensor histidine kinase Length = 578 Score = 266 bits (680), Expect = 4e-69, Method: Compositional matrix adjust. Identities = 175/594 (29%), Positives = 321/594 (54%), Gaps = 27/594 (4%) Query: 10 KHLKNNLFMKIILIFSIIAVVTTITFSYLMFLLMSQSVVQRQ-LEIQKRTVESVNDYMQH 68 K K+NL+ ++ + ++I+ +++ ++ + FL + ++R L + + ++ VN+ +++ Sbjct: 2 KFSKSNLYKRLFITYTIV-ILSVVSILCIYFLSKTSEEIKRNNLYLNDKILQDVNETLEY 60 Query: 69 KYNAVQTMMRDVYRDSELTANTSYLLEHPYQDYVTYRLDRYLNETSTTTDSVQ-FFRNQL 127 + + +M +Y D + L DY+ +LD Y + ++ F ++ Sbjct: 61 NSSTSRRIMNMLYEDDFRLNDVIKYLNSDLVDYIKGKLDYYSASDKLYYNGIESFVKSSF 120 Query: 128 EDDPDIRRLLLYSSVKQQLYVFNDRENFNIISTNAAHSLVPDALYLEEASSVTLPNIWVR 187 + + ++ + S + ++ VFN + N+ L D +E A I+ + Sbjct: 121 QLNNFLKSISFISYSRNEISVFNRKGEIKTYPFNSNELL--DKKDIEYA-------IYNK 171 Query: 188 KTISLSDSPMFSIRVPINDKQSLRNIGQLLVFYDADHIWKSMGDYKDDFKGDIIVLSADN 247 IS+ + I D SL+ G L+ YD I + YKD ++++L+ + Sbjct: 172 NEISIINE--------IRDAASLKPEGMLMTTYDVGVISDVIKKYKDT-NSEVLILNKEG 222 Query: 248 DVLFDSSGTFYGKKYPYPEQIEAIYADGEKVNGMLITKLTHTQGGFTVLSAVPERELAAT 307 VL+DS + + YPY ++++ + + + L G ++S V + AT Sbjct: 223 MVLYDSENKYDYEYYPYFDKLKVGRHEILLEDSYYVDILPDNNG---LMSVVRIKVSNAT 279 Query: 308 YRGLRNMIVIICLICILFAVITPSLFIS--NFATRAHNIIRFTRKVKNGDLDARIADVKE 365 L + + LF + L+I N ++R +++ KV+ GD+D I K+ Sbjct: 280 KVPLLFKVSAFLVSLFLFIIAECVLYIKFKNLSSRMDSLVLAMEKVEKGDIDVHIPLSKD 339 Query: 366 -DELGQISKSFNDMLDELNLYIDRVFKAEIKQKHSEISALEARVNPHFLYNTLEVIRMRA 424 DE+ I+ +FN M ++LN +I + + AE++Q+ +EI AL+ ++NPHFLYNTLE IRM+A Sbjct: 340 RDEITFIADNFNKMCEKLNDHIRKSYLAELRQREAEIVALQNQINPHFLYNTLESIRMKA 399 Query: 425 ISQGAADVGEMIYSLSVLFKSYVHPKAKHTMKDELEACRLYLELFRIRYKDKFSYELHCP 484 I G +VG+M+YSL+ LF+S V ++ E++ C YLELF+ RY +KF +++ C Sbjct: 400 ICNGDKEVGKMLYSLAFLFRSQVKGNLIVSIDQEIKYCNKYLELFKFRYDEKFKFKIECE 459 Query: 485 KELEGRVVLKMSLQPIVENYILHGMRTDRSDNHISIHLAKEGVILRAVVTDNGRGIKQER 544 ++L + ++K +LQP++ENY +HG+R +R DN + I++ K + V DNGRGI +E+ Sbjct: 460 EDLYDKGIVKFTLQPLIENYFVHGIRLERDDNELKIYIYKHLEDIVVEVIDNGRGIPKEK 519 Query: 545 LEQIQHDLLDKDSSSESFGLRSINERMKLLYGEPHGLAVDSEEGKGTTVTVCFP 598 L+ I + + D S +S G+ +++ER+K+ YGEP+GL V SEE KGT + + FP Sbjct: 520 LDDINRRIRECDHSGKSIGMLNVHERIKIKYGEPYGLTVTSEENKGTNMILKFP 573 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.321 0.137 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,441,610,738 Number of extensions: 142427358 Number of successful extensions: 411325 Number of sequences better than 1.0e-05: 1896 Number of HSP's gapped: 408926 Number of HSP's successfully gapped: 1897 Length of query: 608 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 466 Effective length of database: 1,722,912,073 Effective search space: 802877026018 Effective search space used: 802877026018 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 134 (56.2 bits)