BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0073.0015.p (601 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B1D7X4.1 B1D7X4_9BACL Integral membrane sensor signal transducti... 630 e-178 B3KDQ9.1 B3KDQ9_9BACI Histidine kinase internal region 599 e-169 Q9KBL7.1 Q9KBL7_BACHD Two-component sensor histidine kinase 490 e-136 Q5WIY4.1 Q5WIY4_BACSK Two-component sensor histidine kinase 449 e-124 B9MLE3.1 B9MLE3_ANATD Putative sensor with HAMP domain 351 1e-94 >B1D7X4.1 B1D7X4_9BACL Integral membrane sensor signal transduction histidine kinase Length = 595 Score = 630 bits (1624), Expect = e-178, Method: Compositional matrix adjust. Identities = 314/588 (53%), Positives = 413/588 (70%), Gaps = 2/588 (0%) Query: 15 MNNLRLRTKLFLSFGCVALIPVLIVGVFLTSELRNMAMDNALKQITANVDRVKKRTGELL 74 +NN++LRTKL LS VA IP+LIVGVFLT+ELRNMA+DNA++Q NV RVK RT EL+ Sbjct: 9 LNNVKLRTKLILSCIVVAFIPILIVGVFLTNELRNMALDNAMEQTHTNVQRVKARTTELM 68 Query: 75 DVPLDIAYRLSNDSRLEEAANHRYVSVYDVVQAYWNYPDFREFVRLYREISSIRLYIDNP 134 +V D AYRL N SRLE N +Y S Y+VV+AY Y DF E + + E+++IR Y++NP Sbjct: 69 NVAYDSAYRLEN-SRLEAVTNRKYESTYEVVKAYREYTDFNEIRQQHDEVANIRFYMENP 127 Query: 135 TVLDNWEFLQADGTVTQEPWYRTALAQKGMVCWNYIRDNRDGRYYLSLIRKVNFFKQRTS 194 T+L+NW+F+Q D ++ + WY AL V W Y+ D RD R YLSL+R ++F TS Sbjct: 128 TMLNNWDFIQPDNSMKETVWYANALRPGSGVNWYYLEDERDKRNYLSLVRGISFSSNNTS 187 Query: 195 GVLVVNVNTDRLNGILNQESFETLIVDENDNIVASNRTELLGQTLNDLNFKAE-SAAGPG 253 GVLV+ +N LN ILNQESFET+IVD+N+ IVA+NR G+TL +++++ G Sbjct: 188 GVLVITLNMQALNSILNQESFETMIVDDNNRIVAANRMGRAGKTLQEIDYEQSIVEEQSG 247 Query: 254 FYDVSIDGKPFTMLIDDWQPGGSLNSLRIISIFSVESIVKEPNRXXXXXXXXXXXXXXXX 313 Y +IDG+ +LI+ P S N+LRIIS+FSV++IV + NR Sbjct: 248 MYSANIDGQASRVLIEPLIPEASGNTLRIISVFSVDTIVADANRINSLALTVISISLVIA 307 Query: 314 XXXXYYFSRLLTGRMLQLSKHISKVGSGNLGATLVIDGKDEIGQLARQFNHMVRNINDLM 373 S ++T RML+LSKHI+KV +G L + IDGKDEIGQL+RQFN MV +IN L+ Sbjct: 308 IFLIIGVSTIITKRMLRLSKHITKVATGKLDIVMEIDGKDEIGQLSRQFNSMVSSINGLV 367 Query: 374 SEVQESNRQKNAILLKQNEIKFKMMASQINPHFLFNALESIRMKAHVRGQADISQVVRLL 433 EVQESN+ K + KQNEIK KMMASQINPHFLFNALESIRMKAH++G+ +ISQVVRLL Sbjct: 368 EEVQESNKMKRQLEAKQNEIKLKMMASQINPHFLFNALESIRMKAHLKGEKEISQVVRLL 427 Query: 434 GKMMRKNLEVGNRRISLQSELETVSCYLVIQKFRYDDRLAYELHIDPKANLVQIPPLIIQ 493 GK+MR+++EV R L E++ V CYL IQKFRY+DRL+YELH+DP V IPPLIIQ Sbjct: 428 GKLMRRSIEVSQRLTPLADEMDIVRCYLDIQKFRYEDRLSYELHVDPVVERVSIPPLIIQ 487 Query: 494 PLVENSVVHGLENRIDGGMVRVDIRIEDGLLKVQVSDNGAGISKTRMHEIRQMLESKDDY 553 PLVEN+V+HG EN+++GGMV V E ++V V DNGAG+++ ++ ++ Q L +D Sbjct: 488 PLVENAVIHGFENKVEGGMVTVRAVREGDYVRVDVIDNGAGMTREKIDKLTQHLNETEDA 547 Query: 554 ESNNIGMRNIHLRLKLTYGPECGLTLASQEGFGTQISFEIPLRSDSYV 601 E+N IG+RN+HLRL+LTYGPE GL S+ G GT++SF +P D YV Sbjct: 548 ENNRIGLRNVHLRLQLTYGPEHGLQYESEPGIGTKVSFTLPFGEDLYV 595 >B3KDQ9.1 B3KDQ9_9BACI Histidine kinase internal region Length = 602 Score = 599 bits (1545), Expect = e-169, Method: Compositional matrix adjust. Identities = 315/598 (52%), Positives = 419/598 (70%), Gaps = 9/598 (1%) Query: 7 MYARIITSMNNLRLRTKLFLSFGCVALIPVLIVGVFLTSELRNMAMDNALKQITANVDRV 66 M + I +N++++R KL LSF V +PV IVG+FLT ELR A DNAL+Q NVDRV Sbjct: 1 MLSNFIQLINDMKIRNKLILSFVVVVFVPVAIVGIFLTGELRKFAFDNALEQAYQNVDRV 60 Query: 67 KKRTGELLDVPLDIAYRLSNDSRLEEAANHRYVSVYDVVQAYWNYPDFREFVRLYREISS 126 KKR+ E+++V D++YRLS D RL AN +Y SVYDV AY YPD ++ +R+Y+EIS+ Sbjct: 61 KKRSTEVINVADDLSYRLSYDERLRNLANRQYESVYDVFVAYREYPDLQQAIRMYKEISN 120 Query: 127 IRLYIDNPTVLDNWEFLQADGTVTQEPWYRTALAQKGMVCWNYIRDNRDGRYYLSLIRKV 186 IR Y DNPT+L+NWEFL + WYR A G++ W+YI D RD + YLSLI+ V Sbjct: 121 IRFYSDNPTMLNNWEFLYPKDEIRSTEWYRRAEDDIGVIYWDYIEDERDQKVYLSLIKGV 180 Query: 187 NFFKQRTSGVLVVNVNTDRLNGILNQESFETLIVDENDNIVASNRTELLGQTLNDLNFKA 246 + + GVLV+NVNT LN IL+QE+F+T+IVD ++NIVA+NR EL G+TL ++ Sbjct: 181 DLGSKDNRGVLVINVNTGMLNTILSQEAFDTIIVDSSNNIVAANRPELYGKTLAEI---- 236 Query: 247 ESAAGP-----GFYDVSIDGKPFTMLIDDWQPGGSLNSLRIISIFSVESIVKEPNRXXXX 301 E A+G G Y+ I + +LI+ +N LRIISIFS++SIV + NR Sbjct: 237 EDASGAVYHASGSYESVIHDEASKVLIEPLNTESGVNGLRIISIFSIDSIVADANRISKL 296 Query: 302 XXXXXXXXXXXXXXXXYYFSRLLTGRMLQLSKHISKVGSGNLGATLVIDGKDEIGQLARQ 361 Y FS L++ R+L+LSKHI+KVG+GNLG + IDGKDEIGQL+RQ Sbjct: 297 AMTVIIISLLLAVLLIYSFSSLISNRLLRLSKHITKVGTGNLGVAMEIDGKDEIGQLSRQ 356 Query: 362 FNHMVRNINDLMSEVQESNRQKNAILLKQNEIKFKMMASQINPHFLFNALESIRMKAHVR 421 FN MV N+NDLM+EVQESN QK + KQNEIKFKMMASQINPHFLFNALESIRM+AH++ Sbjct: 357 FNSMVGNVNDLMNEVQESNEQKRLMEQKQNEIKFKMMASQINPHFLFNALESIRMEAHLK 416 Query: 422 GQADISQVVRLLGKMMRKNLEVGNRRISLQSELETVSCYLVIQKFRYDDRLAYELHIDPK 481 G+ +I+++VRLLGKMMR NLEVG+ + +++ E+E V CYL IQKFRY+DRL YEL +DP+ Sbjct: 417 GETEIARIVRLLGKMMRSNLEVGSGKTTIKDEIEMVQCYLDIQKFRYEDRLKYELQVDPE 476 Query: 482 ANLVQIPPLIIQPLVENSVVHGLENRIDGGMVRVDIRIEDGLLKVQVSDNGAGISKTRMH 541 AN V+IPPLIIQPLVEN+V+HG++++ +G ++V + +G L V DNGAGIS ++ Sbjct: 477 ANRVRIPPLIIQPLVENAVIHGMDHKEEGTSIKVRVTASEGKLHVMTEDNGAGISLDKLQ 536 Query: 542 EIRQMLESKDDYESNNIGMRNIHLRLKLTYGPECGLTLASQEGFGTQISFEIPLRSDS 599 I L D+ + IG+RN+H+RL+LTYGPE GL + S+ G GT+I F IP +S Sbjct: 537 MIYGYLNDTDEKDGGRIGLRNVHVRLQLTYGPEAGLIIYSEPGIGTRIEFSIPTGGES 594 >Q9KBL7.1 Q9KBL7_BACHD Two-component sensor histidine kinase Length = 597 Score = 490 bits (1262), Expect = e-136, Method: Compositional matrix adjust. Identities = 256/598 (42%), Positives = 388/598 (64%), Gaps = 4/598 (0%) Query: 7 MYARIITSMNNLRLRTKLFLSFGCVALIPVLIVGVFLTSELRNMAMDNALKQITANVDRV 66 MY+ +I ++N+++LR KL F V P++IVG+FLT+ELR+ A+ +A++Q NV+RV Sbjct: 1 MYSTLIQTINDMKLRDKLMFMFVVVVFFPMMIVGIFLTNELRSNAIQDAIQQSRVNVERV 60 Query: 67 KKRTGELLDVPLDIAYRLSNDSRLEEAANHRYVSVYDVVQAYWNYPDFREFVRLYREISS 126 K+RT E+L+VP+ IA L D R E N Y + YDVV AY Y +F +++ Y EI + Sbjct: 61 KERTTEVLNVPVLIANNLQFDERFIELVNQEYETTYDVVDAYLQYMNFTNYLQYYSEIHN 120 Query: 127 IRLYIDNPTVLDNWEFLQADGTVTQEPWYRTALAQKGMVCWNYIRD-NRDGRYYLSLIRK 185 ++ Y +N ++++NW + + +E W++ A+A W Y+ D + + YLS++++ Sbjct: 121 MKYYSENTSLMNNWVIIPVEHEAGEE-WFKEAMADPAYYRWFYLEDETKKNQAYLSMVKR 179 Query: 186 VNFFKQRTSGVLVVNVNTDRLNGILNQESFETLIVDENDNIVASNRTELLGQTLND-LNF 244 +NF + ++GVLV+ V+ +L+ IL QESF T+IVDE + I A+N+ E +G+ L++ ++F Sbjct: 180 LNFLEYGSAGVLVITVDPRKLDRILQQESFTTMIVDERNRIAATNQREYIGKDLHEVIDF 239 Query: 245 KAESAAGPGFYDVSIDGKPFTMLIDDWQPGGSLNSLRIISIFSVESIVKEPNRXXXXXXX 304 GP Y+ ++G+P +++D S + L+IISI + E I+K+ R Sbjct: 240 HEMIQEGPAIYEGKMNGEPSQIIVDYLTLQMSQSELKIISIVTKEHIMKDAKRLSIMGAT 299 Query: 305 XXXXXXXXXXXXXYYFSRLLTGRMLQLSKHISKVGSGNLGATLVIDGKDEIGQLARQFNH 364 +FS L++ R+ LS+ I++V SG+L +V+DGKDEIGQL+ QFN Sbjct: 300 VTMGGMAVAVLLIVHFSWLISKRLSHLSERINQVASGDLKTKIVVDGKDEIGQLSVQFNQ 359 Query: 365 MVRNINDLMSEVQESNRQKNAILLKQNEIKFKMMASQINPHFLFNALESIRMKAHVRGQA 424 MV N+ L+ +V E+NRQK + QNEIK KM+ASQINPHFLFN LESIRMK+H++G+ Sbjct: 360 MVANLRSLIHQVHETNRQKRLLEKSQNEIKLKMLASQINPHFLFNTLESIRMKSHMKGET 419 Query: 425 DISQVVRLLGKMMRKNLEVGNRRISLQSELETVSCYLVIQKFRYDDRLAYELHIDPKANL 484 +I++VV+ LGK+MRK+LEV I L++EL+ V CYL IQ FRY DRL YEL+IDP++ + Sbjct: 420 EIAKVVKQLGKLMRKSLEVTGHHIPLRNELDMVRCYLEIQTFRYGDRLHYELYIDPQSEM 479 Query: 485 VQIPPLIIQPLVENSVVHGLENRIDGGMVRVDIRIEDGLLKVQVSDNGAGISKTRMHEIR 544 V+I PLIIQPLVEN+V+HGLE DGG V + + L V V+D+G G+ + ++ I+ Sbjct: 480 VEILPLIIQPLVENAVIHGLERTEDGGTVTISTIVNGNDLTVIVNDDGCGMDEEKLEAIQ 539 Query: 545 QMLESKDDYESNNIGMRNIHLRLKLTYGPECGLTLASQEGFGTQISFEIP-LRSDSYV 601 ML + + N IG+ N+H RL+LTYG GL + S +G GT + F I +R D V Sbjct: 540 NMLHHPQEVDGNKIGLLNVHKRLQLTYGKTSGLIIESAKGKGTCVRFTISQIRGDDDV 597 >Q5WIY4.1 Q5WIY4_BACSK Two-component sensor histidine kinase Length = 599 Score = 449 bits (1156), Expect = e-124, Method: Compositional matrix adjust. Identities = 242/594 (40%), Positives = 361/594 (60%), Gaps = 6/594 (1%) Query: 11 IITSMNNLRLRTKLFLSFGCVALIPVLIVGVFLTSELRNMAMDNALKQITANVDRVKKRT 70 + T +N +++R KL L F +IP+ +VG+FLT+EL+ A+ +A +Q NV+RVK+R Sbjct: 9 VSTKLNQIKIRDKLILMFLSSVVIPIAVVGLFLTNELKANAIKDAQEQADMNVERVKQRI 68 Query: 71 GELLDVPLDIAYRLSNDSRLEEAANHRYVSVYDVVQAYWNYPDFREFVRLYREISSIRLY 130 E+L P+ +A L D RL E N Y + V QAY +YPDF + EI +IRLY Sbjct: 69 NEVLKGPIMVANHLQFDERLSELVNTDYEHSFSVFQAYRSYPDFAYHKGNHPEIETIRLY 128 Query: 131 IDNPTVLDNWEFLQADGTVTQEPWYRTALAQKGMVCWNYIRD-NRDGRYYLSLIRKVNFF 189 +DNPT+L+NW F+ + + WY A A G W Y++D + G +YLSL++++NF Sbjct: 129 VDNPTLLNNWTFIPVERS-QMASWYTIAKADVGFYQWFYLQDETQGGGHYLSLMKRINFI 187 Query: 190 KQRTSGVLVVNVNTDRLNGILNQESFETLIVDENDNIVASNRTELLGQTLNDLNFKAESA 249 + T G+LV+ + D L I+ QE+ +T++VDE ++I++S+ +G+ L++L + Sbjct: 188 EYGTFGLLVITIAPDLLETIMQQETHQTVVVDEQNSIISSSEPSFIGENLDELVVVTDRG 247 Query: 250 AGP-GFYDVSIDGKPFTMLIDDWQPGGSLNSLRIISIFSVESIVKEPNRXXXXXXXXXXX 308 G GFY+ +G+P M+ P S N LRI+SI E IV + Sbjct: 248 EGKHGFYEGQANGEPIHMMETSLFPELSQNQLRIVSIIHTEDIVGAAKKLSYFGVLVTGL 307 Query: 309 XXXXXXXXXYYFSRLLTGRMLQLSKHISKVGSGNLGATLVIDGKDEIGQLARQFNHMVRN 368 +FS R+ +LS + +V GNL + +DG DEIGQ++ Q N M+ + Sbjct: 308 GIAFSLFLIVWFSWGYVNRLSRLSATMKEVAQGNLTTKVALDGTDEIGQISLQLNKMIDD 367 Query: 369 INDLMSEVQESNRQKNAILLKQNEIKFKMMASQINPHFLFNALESIRMKAHVRGQADISQ 428 +N+ ++++ E+N QK A+ KQNE+KFKMMASQ+NPHFLFN LE+IRM+AH+ + DI++ Sbjct: 368 LNESIAQLLEANEQKTALERKQNEMKFKMMASQMNPHFLFNTLEAIRMRAHMSNETDIAK 427 Query: 429 VVRLLGKMMRKNLEVGNRRISLQSELETVSCYLVIQKFRYDDRLAYELHIDPKANLVQIP 488 V+ LG+++RK+LEVG+ I L+ ELE V YL IQ FRY +RL Y++ + V + Sbjct: 428 AVKRLGQLLRKSLEVGSSMIPLKEELEMVRSYLEIQSFRYGERLTYDMDDAVTIDNVAVI 487 Query: 489 PLIIQPLVENSVVHGLENRIDGGMVRVDIR-IEDGLLKVQVSDNGAGISKTRMHEIRQML 547 PL IQPLVEN+V HGLE + G V + I+ EDG ++VSDNG G+ R E++ M+ Sbjct: 488 PLTIQPLVENAVSHGLEAKEADGYVNIRIKQAEDGTW-IEVSDNGIGMGPQRQQEVQAMI 546 Query: 548 ESKDDYESNNIGMRNIHLRLKLTYGPECGLTLASQEGFGTQISFEIPLRSDSYV 601 E + N IG+RN+H RLK TYG + GL ++S +G GT + F IP SYV Sbjct: 547 EDPLEKPENRIGLRNVHQRLKQTYGTD-GLLISSSQGEGTTVRFLIPKEEGSYV 599 >B9MLE3.1 B9MLE3_ANATD Putative sensor with HAMP domain Length = 587 Score = 351 bits (901), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 202/586 (34%), Positives = 329/586 (56%), Gaps = 14/586 (2%) Query: 15 MNNLRLRTKLFLSFGCVALIPVLIVGVFLTSELRNMAMDNALKQITANVDRVKKRTGELL 74 + NL++R K L+F A IP +++G+ L L +A++NA+ NV VKK ++L Sbjct: 5 LTNLKMRKKFILAFIISAFIPQIVLGIILFLNLHAIALENAINNTKRNVQDVKKNLLDVL 64 Query: 75 DVPLDIAYRLSNDSRLEEAANHRYVSVYDVVQAYWNYPDFREFVRLY-REISSIRLYIDN 133 +DI+ +L D +L + + Y V + + Y +Y +F + +Y + I I++Y N Sbjct: 65 QNAVDISNKLYLDKKLLDILSTEYSDVSKLYEDYTSYKEFSNLLSIYNKNIHLIKVYTFN 124 Query: 134 PTVLDNWEFLQADGTVTQEPWYRTALAQKGMVCWNYIRDNRDGR--YYLSLIRKVNFFKQ 191 PT+LD EF++ D + ++ W+ AL + G + W I DN R YY SL+R + Sbjct: 125 PTLLDTGEFVKVDNYIKKQRWFIHALKEDGKILWELIFDNSPFRPQYYFSLVRLLKNSYG 184 Query: 192 RTSGVLVVNVNTDRLNGILNQESFETLIVDENDNIVASNRTELLGQTLNDLNFKAESAAG 251 GV+V+ + ++++ IL+Q T++V + +VA+ L+G+T++ KA Sbjct: 185 EKVGVMVIYIKKEKIDEILSQNE-NTIVVTDKGTVVAAKDESLIGKTID---IKAFEDGD 240 Query: 252 PGFYDVSIDGKPFTMLIDDWQP---GGSLNSLRIISIFSVESIVKEPNRXXXXXXXXXXX 308 +V I+ + L+ P GG N L++IS FS + I K PN+ Sbjct: 241 RLIENVKINQRNLMALVGTIAPNETGG--NYLKVISFFSKKEIFKVPNKVSFFAFVVITV 298 Query: 309 XXXXXXXXXYYFSRLLTGRMLQLSKHISKVGSGNLGATLVIDGKDEIGQLARQFNHMVRN 368 FS+L+T R+ L++ ++++ G L ++ I GKDEIGQLA M +N Sbjct: 299 NLLISLFLMLLFSKLITDRLTILNEKVNQISHGKLDTSIEILGKDEIGQLAENVKEMAKN 358 Query: 369 INDLMSEVQESNRQKNAILLKQNEIKFKMMASQINPHFLFNALESIRMKAHVRGQADISQ 428 I +L+ +V + QK ++ KQ EI+F+M+ SQINPHF+FN LE+IRMKA GQ +IS Sbjct: 359 IKNLIEQVYLAEIQKQQMITKQREIQFEMLCSQINPHFIFNTLEAIRMKAFCSGQEEISH 418 Query: 429 VVRLLGKMMRKNLEVGNRRISLQSELETVSCYLVIQKFRYDDRLAYELHIDPKANLVQIP 488 +V LL ++RK++ V + ISL+ E+E V +L IQKFR+ DR+ +++ ID +I Sbjct: 419 IVYLLSNLLRKSITVSSELISLKEEIEFVQQFLEIQKFRFGDRIDFDIQIDEDLFNQKIL 478 Query: 489 PLIIQPLVENSVVHGLENRIDGGMVRVDIRIEDGLLKVQVSDNGAGISKTRMHEIRQMLE 548 P IIQPLVENS+ HG+E ++ G + + I D + ++V DNG G+ K + +L+ Sbjct: 479 PFIIQPLVENSIKHGIEPKVGKGYISIRIFKRDEKIVIRVEDNGIGMKKEECDNLITLLK 538 Query: 549 SKDDYESNNIGMRNIHLRLKLTYGPECGLTLASQEGFGTQISFEIP 594 S D + ++G+RN++ RLKL YG E + S+ G GT + +P Sbjct: 539 S--DQKDAHVGLRNVYTRLKLFYGNEFEFLIKSEYGSGTVVEITVP 582 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.321 0.138 0.394 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,149,876,848 Number of extensions: 125029016 Number of successful extensions: 386499 Number of sequences better than 1.0e-05: 2171 Number of HSP's gapped: 383412 Number of HSP's successfully gapped: 2176 Length of query: 601 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 459 Effective length of database: 1,722,912,073 Effective search space: 790816641507 Effective search space used: 790816641507 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 134 (56.2 bits)