BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0043.0024.p (598 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3KA19.1 B3KA19_9BACI Histidine kinase internal region 581 e-164 B1DAK2.1 B1DAK2_9BACL Integral membrane sensor signal transducti... 551 e-155 A6TTD2.1 A6TTD2_ALKMQ Histidine kinase internal region 492 e-137 Q9K6Q0.1 Q9K6Q0_BACHD Two-component sensor histidine kinase 476 e-132 Q09LZ7.1 Q09LZ7_BACST Two-component sensor histidine kinase 437 e-120 >B3KA19.1 B3KA19_9BACI Histidine kinase internal region Length = 590 Score = 581 bits (1498), Expect = e-164, Method: Compositional matrix adjust. Identities = 291/580 (50%), Positives = 407/580 (70%), Gaps = 5/580 (0%) Query: 4 KIKELNTLRNQIFIGFLLVMLIIIAVSGAFVYNRVSYLLKNNAERHIQQTAVQANGRLDA 63 + LNTLRNQIF+GF+LVM+I++A+ G FVY++VS LL+N+AE+HIQQTAVQA G+LDA Sbjct: 3 RFGRLNTLRNQIFLGFMLVMIIVLALVGVFVYDQVSALLRNSAEKHIQQTAVQATGKLDA 62 Query: 64 LIGQIDSLMEQVANHPTIQQLLTEELDGKSVTFNQRQSLLQIISSYQAYMPSVGSLELYT 123 L+ Q+D+L QV+ + T+Q+ L +E G +TF +RQSL Q + Y+AY + SLELYT Sbjct: 63 LLKQVDTLTAQVSTNATVQRYLAQETAGHPITFGERQSLQQEVRKYEAYATGIRSLELYT 122 Query: 124 ADYRLLFPIRDGSLETRINSAYITSANTKKGRLVWIGVDPKDEESLLAIRQVSLMDRWFS 183 DYR LFP+ +GSL +R+ +I +A+ G+LVW G DP+D + ++A+R++ L+D F Sbjct: 123 TDYRRLFPLDEGSLTSRVGVDWIIAADKGMGKLVWFGQDPRDPDVVVAVRRIRLIDHSFM 182 Query: 184 RGGYLMARIQRSYFQLDDPLSG--SDGGESVLLVNDEGELLGXXXXXXXXXXXXXXXKDQ 241 GGYL+ ++++ YF L D G SD E++ L + G + + + Sbjct: 183 HGGYLLVKLEKDYFALTDSAGGMGSDSRETMGLFDQAGHEISSDFATAVDSRAVLHREGE 242 Query: 242 TVSFRGKEYVQVKLRSDKTNWTLLVLTPVSYVTRGLSVLRTVLLVSGGFGTLLFLIMSFV 301 TV+ ++Y+ V+ +S T W L++LTPV Y T G+SVLRT ++VSGG G LLFLI+SF+ Sbjct: 243 TVTVGDEDYIAVQRQSAATGWNLVILTPVDYTTEGISVLRTAIIVSGGVGALLFLILSFI 302 Query: 302 LSTMITRPIIQLIRAMRKSRLGVLTPNPESVSTIELRELNNTYNGMIANMNDLIRVVYEK 361 L+TMI RPI+ LI+AMR RLG L P + T+E+ ELNN+YN M+ ++N+LI VVY+K Sbjct: 303 LTTMIIRPILNLIKAMRGVRLGTLKPIAVTSKTMEINELNNSYNQMVDSLNELIEVVYQK 362 Query: 362 EVLQSRTELKALQAQINPHFLFNTLEAFNWSXXXXXXXXXXXXXXXMSRLFRYIIGNPNK 421 E++QSRTELKALQAQINPHFLFNTLEAF W+ MS LFRY+I ++ Sbjct: 363 EIIQSRTELKALQAQINPHFLFNTLEAFYWALDDQGEEELAQIVVAMSGLFRYVINRKDE 422 Query: 422 DEWVTLGEEMEQVQRYLKIMEMRMGDRLSWTIQLGPEEAAVPVPKLLIQPIVENAILHGV 481 DEWV++ +E++ +RYL IM+MRM DRLSW I+ VP+PKLLIQPIVENAILHGV Sbjct: 423 DEWVSVRDELDHAERYLMIMKMRMLDRLSWRIEADEASKNVPIPKLLIQPIVENAILHGV 482 Query: 482 ESRVGSGTVSVIVAPAQRKGWTQITVQDNGPGMDADTLQSLYSALEGGPSISAKGTGIGL 541 E R+G GTV V + + G+T +++ D+GPGMD +T+ SLYS++E G + SAK +G+G+ Sbjct: 483 EQRLGPGTVIVRAQASDQPGYTVVSIADDGPGMDEETVASLYSSMEKGYAESAKKSGVGI 542 Query: 542 VNVQRRIRLYYEAEGTGVKGLNIESKLSEGTVITFEIPNN 581 NV++RIRLYY +E GL I S L +GT I+F+IPN+ Sbjct: 543 ANVEQRIRLYYASEQA---GLRIHSVLGQGTTISFQIPND 579 >B1DAK2.1 B1DAK2_9BACL Integral membrane sensor signal transduction histidine kinase Length = 584 Score = 551 bits (1420), Expect = e-155, Method: Compositional matrix adjust. Identities = 284/584 (48%), Positives = 394/584 (67%), Gaps = 5/584 (0%) Query: 4 KIKELNTLRNQIFIGFLLVMLIIIAVSGAFVYNRVSYLLKNNAERHIQQTAVQANGRLDA 63 + +NTLRNQIF+GF+LVML+++A G F Y +VS LL+NNAE HIQQTAVQA G++D Sbjct: 3 QFNRMNTLRNQIFLGFVLVMLLVLASVGFFTYGQVSELLRNNAENHIQQTAVQATGKMDV 62 Query: 64 LIGQIDSLMEQVANHPTIQQLLTEELDGKSVTFNQRQSLLQIISSYQAYMPSVGSLELYT 123 L+ Q+++ QVA + +IQ L+ +E G ++TF +RQ L I QAY+ V S+ELY+ Sbjct: 63 LLHQMETFTMQVATNASIQNLMAKEAGGTNLTFEERQVLQHEIRKQQAYVSGVQSIELYS 122 Query: 124 ADYRLLFPIRDGSLETRINSAYITSANTKKGRLVWIGVDPKDEESLLAIRQVSLMDRWFS 183 +R+LFP+ D SL R+ + +I A+ G+LVW G+DP + + AIR+V L+D+ FS Sbjct: 123 NGFRVLFPLTDISLYNRVPNEWIREADRAAGQLVWFGIDPNNPNQITAIRRVRLIDQSFS 182 Query: 184 RGGYLMARIQRSYFQLDDPLSGSDGGESVLLVNDEGELLGXXXXXXXXXXXXXXXKDQTV 243 GYL+ RI + YF+L D + SDG E + L++ G+++ +T+ Sbjct: 183 NAGYLLVRIDKKYFELIDTNTSSDGKEEMGLIDGSGQIIAANFSADIPQDVLQRTDGKTI 242 Query: 244 SFRGKEYVQVKLRSDKT-NWTLLVLTPVSYVTRGLSVLRTVLLVSGGFGTLLFLIMSFVL 302 S G+ Y+ ++ + + W +L+LTP Y G+SVLRT ++VS G LLFLI++F+L Sbjct: 243 SMHGRLYIPIQKQLEAAAGWKVLILTPAEYAAEGVSVLRTAIIVSVMVGVLLFLILTFIL 302 Query: 303 STMITRPIIQLIRAMRKSRLGVLTPNPESVSTIELRELNNTYNGMIANMNDLIRVVYEKE 362 STMIT PI+ LI+AMR ++ G L P P + ST+E+ ELNNTYN M+A +N+LI VVYEKE Sbjct: 303 STMITSPILNLIKAMRGAKYGSLKPIPVTSSTLEINELNNTYNQMVAYLNELIEVVYEKE 362 Query: 363 VLQSRTELKALQAQINPHFLFNTLEAFNWSXXXXXXXXXXXXXXXMSRLFRYIIGNPNKD 422 ++QSRTELKALQAQINPHFLFNTLEA W+ MS LFRY+I + D Sbjct: 363 IIQSRTELKALQAQINPHFLFNTLEALYWALEDKDEEELSQVVVAMSGLFRYVINRADGD 422 Query: 423 EWVTLGEEMEQVQRYLKIMEMRMGDRLSWTIQLGPEEAAVPVPKLLIQPIVENAILHGVE 482 EWVT+ +E+E +RYLKIMEMR+ DRL W+I+ VP+PKLLIQP+VENAI HGVE Sbjct: 423 EWVTVADELEHAERYLKIMEMRLIDRLKWSIEGDESLRGVPIPKLLIQPLVENAISHGVE 482 Query: 483 SRVGSGTVSVIVAPAQRKGWTQITVQDNGPGMDADTLQSLYSALEGGPSISAKGTGIGLV 542 R+G G+V + + +R G+ +I+V DNGPGM+ D +QSLY+A++ G AKGTG+G+ Sbjct: 483 QRIGQGSVVIGIEKTERPGYIRISVTDNGPGMNFDKVQSLYAAMKQGHVHDAKGTGVGIS 542 Query: 543 NVQRRIRLYYEAEGTGVKGLNIESKLSEGTVITFEIP-NNGGHT 585 NV RRIRLYY G +GL I+S+ GT ++FEIP +GG Sbjct: 543 NVDRRIRLYY---GEETEGLQIQSEQGTGTRMSFEIPIEHGGEA 583 >A6TTD2.1 A6TTD2_ALKMQ Histidine kinase internal region Length = 578 Score = 492 bits (1266), Expect = e-137, Method: Compositional matrix adjust. Identities = 266/580 (45%), Positives = 368/580 (63%), Gaps = 9/580 (1%) Query: 2 YGKIKELNTLRNQIFIGFLLVMLIIIAVSGAFVYNRVSYLLKNNAERHIQQTAVQANGRL 61 + K + NTLRNQI + FL V+++++ +N VS LLK+NAE IQ+T +Q + R+ Sbjct: 5 FNKFSKFNTLRNQILVVFLFVIILVLFFVSISTFNIVSSLLKSNAEIQIQETTIQVSERV 64 Query: 62 DALIGQIDSLMEQVANHPTIQQLLTEELDGKSVTFNQRQSLLQIISSYQAYMPSVGSLEL 121 D L QID + QV +QQLL +E++GK+ +F+QRQ+L+Q+++ YQAY + S EL Sbjct: 65 DTLYRQIDIISRQVITDSYVQQLLLDEVEGKTASFDQRQALMQVVNRYQAYSDGIHSFEL 124 Query: 122 YTADYRLLFPIRDGSLETRINSAYITSANTKKGRLVWIGVDPKDEESLLAIRQVSLMDRW 181 Y DY+ +FP+ L +R++ +I A KG+LVWIG DPKD L IRQVSL+DRW Sbjct: 125 YLRDYKRIFPLNGMVLPSRVDEKWIEQAKDAKGKLVWIGRDPKDPNLYLGIRQVSLIDRW 184 Query: 182 FSRGGYLMARIQRSYFQLDDPLSGSDGGESVLLVNDEGELLGXXXXXXXXXXXXXXXKDQ 241 FS GGYL+ RI +YF+L D E +++V+ + + K+ Sbjct: 185 FSNGGYLLTRIDENYFRLKDESKTGKDNEYMVIVDQKNSPVFSNYYGDIEEIVMENQKN- 243 Query: 242 TVSFRGKEYVQVKLRSDKTNWTLLVLTPVSYVTRGLSVLRTVLLVSGGFGTLLFLIMSFV 301 V+ Y+ VK +S T WT ++LTPV+ + GLSVLR ++ SG G +F SF+ Sbjct: 244 -VNINEANYIVVKKKSALTGWTAVILTPVNTLMNGLSVLRAAIIFSGIAGFSIFFFFSFI 302 Query: 302 LSTMITRPIIQLIRAMRKSRLGVLTPNPESVSTIELRELNNTYNGMIANMNDLIRVVYEK 361 LS MITRPI+ LIR M+ ++LG L P ES ST+EL ELN TYN ++ N N L+ VVYEK Sbjct: 303 LSIMITRPILNLIRTMQIAKLGGLKPIAESASTVELVELNKTYNQLVENTNHLMEVVYEK 362 Query: 362 EVLQSRTELKALQAQINPHFLFNTLEAFNWSXXXXXXXXXXXXXXXMSRLFRYIIGNPN- 420 E+ + ELKALQAQINPHFL+NTLEA WS MS LFRY I P Sbjct: 363 ELCLRQAELKALQAQINPHFLYNTLEALYWS-LEEKGEELAEVVVAMSDLFRYTISGPKV 421 Query: 421 KDEWVTLGEEMEQVQRYLKIMEMRMGDRLSWTIQLGPEEAAVPVPKLLIQPIVENAILHG 480 + EWV + EE+E V+RYL++M+MR GDRL+W + P + V +PKLLIQP+VENAILHG Sbjct: 422 EQEWVLVKEELEHVERYLQVMKMRFGDRLTWYVS-SPSDCNVKIPKLLIQPLVENAILHG 480 Query: 481 VESRVGSGTVSVIVAPAQRKGWTQITVQDNGPGMDADTLQSLYSALEGGPSISAKGTGIG 540 V ++ G GTVSVIV + I V D+GPG++ D L S+ +L+ G S K G+ Sbjct: 481 VGNKNGQGTVSVIVEDFKLHSRLVIKVIDDGPGIEVDALYSIMQSLKFGRVASIKEKGMA 540 Query: 541 LVNVQRRIRLYY-EAEGTGVKGLNIESKLSEGTVITFEIP 579 + NV +R++LYY + EG+ GL+IESK+++GT +TFEIP Sbjct: 541 IANVHKRLKLYYKDDEGS---GLSIESKVNQGTCVTFEIP 577 >Q9K6Q0.1 Q9K6Q0_BACHD Two-component sensor histidine kinase Length = 605 Score = 476 bits (1225), Expect = e-132, Method: Compositional matrix adjust. Identities = 248/587 (42%), Positives = 364/587 (62%), Gaps = 4/587 (0%) Query: 3 GKIKELNTLRNQIFIGFLLVMLIIIAVSGAFVYNRVSYLLKNNAERHIQQTAVQANGRLD 62 GK K+ NTLRNQIFI F+ VM++++ G +N V +LK NAE+ ++QTA++ R+D Sbjct: 15 GKRKKWNTLRNQIFINFISVMVVVLLFVGFITFNLVMDILKGNAEKQMEQTAIETLHRVD 74 Query: 63 ALIGQIDSLMEQVANHPTIQQLLTEELDGKSVTFNQRQSLLQIISSYQAYMPSVGSLELY 122 + I+ +M Q+A + +IQQLL E +G TF QRQS+ Q+I+SYQAY+ + S ELY Sbjct: 75 SQFEAIEMIMSQIATNGSIQQLLYNEANGHPTTFEQRQSMNQVINSYQAYITGITSFELY 134 Query: 123 TADYRLLFPIRDGSLETRINSAYITSANTKKGRLVWIGVDPKDEESLLAIRQVSLMDRWF 182 DYR LFP+ + L +RI +I A + GR+VW G+DP D +S L +++V+L+D+ F Sbjct: 135 FTDYRRLFPLNELPLPSRIRYEWIEMALEENGRVVWSGIDPLDADSFLTLKKVNLLDQDF 194 Query: 183 SRGGYLMARIQRSYFQLDDPLSGSD-GGESVLLVNDEGELLGXXXXXXXXXXXXXXXKDQ 241 S GGYL++++ +YF+L D + V L + +G+ + Q Sbjct: 195 SHGGYLVSKVNTNYFELRQENGQLDMDNQYVALFDQQGQFITTNMPEEWHDQIAPKTDKQ 254 Query: 242 TVSFRGKEYVQVKLRSDKTNWTLLVLTPVSYVTRGLSVLRTVLLVSGGFGTLLFLIMSFV 301 V+ G +YV+V+ S+KT W+LL+ TPV + +G++ + T +LV+GG G L+F I ++ Sbjct: 255 VVTMDGTDYVRVEAASNKTGWSLLIYTPVHSLAQGITGIGTAILVAGGIGLLIFTISTYF 314 Query: 302 LSTMITRPIIQLIRAMRKSRLGVLTPNPESVSTIELRELNNTYNGMIANMNDLIRVVYEK 361 LS++IT PI +L AMR LG L +P ST+EL ELN+TYN M+ N LI+VVYE+ Sbjct: 315 LSSLITNPIQRLTHAMRFGTLGALKESPSIASTVELNELNDTYNRMVETTNYLIKVVYEQ 374 Query: 362 EVLQSRTELKALQAQINPHFLFNTLEAFNWSXXXXXXXXXXXXXXXMSRLFRYIIGNPNK 421 E+ QSR ELKALQ+QINPHFLFNTLEA WS ++ LFRY I + Sbjct: 375 ELTQSRAELKALQSQINPHFLFNTLEALYWS-LEEKDEEQAEVVIALAELFRYTISDVKG 433 Query: 422 DEWVTLGEEMEQVQRYLKIMEMRMGDRLSWTIQLGPEEAAVPVPKLLIQPIVENAILHGV 481 D+WV L EE + ++RYL IM++R RL+W I+L P V +PKLLIQP+VENAI+HG+ Sbjct: 434 DDWVALHEEFDHIERYLHIMKLRYDHRLAWEIELDPSLREVQIPKLLIQPVVENAIIHGI 493 Query: 482 ESRVGSGTVSVIVAPAQRKGWTQITVQDNGPGMDADTLQSLYSALEGGPSISAKGTGIGL 541 ++V G V V + ++G+ ITV+D+G GMD T Q L +LE K +GI L Sbjct: 494 GNKVDGGKVQVSAYTSVKQGYVNITVRDDGQGMDEKTKQKLEHSLETRVGHPEKRSGIAL 553 Query: 542 VNVQRRIRLYYEAEGTGVKGLNIESKLSEGTVITFEIPNNGGHTYES 588 VN+++R+ L Y ++ + + S+ GT +TF IP + E+ Sbjct: 554 VNIRQRLDLCYASDPH--TSIELTSRHGVGTTVTFTIPKKEAPSDEA 598 >Q09LZ7.1 Q09LZ7_BACST Two-component sensor histidine kinase Length = 575 Score = 437 bits (1125), Expect = e-120, Method: Compositional matrix adjust. Identities = 231/582 (39%), Positives = 368/582 (63%), Gaps = 18/582 (3%) Query: 5 IKELNTLRNQIFIGFLLVMLIIIAVSGAFVYNRVSYLLKNNAERHIQQTAVQANGRLDAL 64 +K+ NTLRNQI I FL VM+I++++ +VS L+++NAE I+QTA++ +GR+D+L Sbjct: 5 LKKWNTLRNQILIVFLFVMVIVLSIVSMITLKQVSLLIRHNAESQIKQTAMETSGRIDSL 64 Query: 65 IGQIDSLMEQVANHPTIQQLLTEELDGKSVTFNQRQSLLQIISSYQAYMPSVGSLELYTA 124 Q+++ + + + +Q+L G+ VTF + Q L ++++ QA + S+ELYT Sbjct: 65 FEQLNTATKFMMTNQEVQRLFERIHAGEKVTFPELQRLKSVVNNIQANSEGIYSVELYTE 124 Query: 125 DYRLLFPIRDGSLET--RINSAYITSANTKKGRLVWIGVDPKDEESLLAIRQVSLMDRWF 182 D + +FP+ D S++ R+N +I A+ KGRLVWIG DP++ + LAIR+++LM+R F Sbjct: 125 DLKQVFPL-DSSMKMFERLNVKWIYEADRAKGRLVWIGEDPRNSQFYLAIRRITLMERQF 183 Query: 183 SRGGYLMARIQRSYFQLDDPLSGSDGGESVLLVNDEGELLGXXXXXXXXXXXXXXXKDQT 242 GGYL+ RI + YF + + + G+ V + + EG+++ ++T Sbjct: 184 VNGGYLLVRIYKPYFSITE----VNTGQYVFVSDPEGKMI---FSNTSNSIDLSSLNERT 236 Query: 243 VSFRGK-EYVQVKLRSDKTNWTLLVLTPVSYVTRGLSVLRTVLLVSGGFGTLLFLIMSFV 301 + + EY+ K SDK +T+ +LTPVS +T+G++ +R ++ +G G L++ + S + Sbjct: 237 ATIMNQTEYMVTKQSSDK-GFTVFILTPVSALTKGINGIRLGIIFAGIIGMLVYFLCSLL 295 Query: 302 LSTMITRPIIQLIRAMRKSRLGVLTPNPESVSTIELRELNNTYNGMIANMNDLIRVVYEK 361 LST+ITRPI+QL + MR + +LT +P+ V+ E+RELN+TYN ++ N LI++VY+K Sbjct: 296 LSTIITRPIVQLTKTMRLANERLLTVDPKMVTVNEIRELNSTYNQLVRETNHLIKMVYQK 355 Query: 362 EVLQSRTELKALQAQINPHFLFNTLEAFNWSXXXXXXXXXXXXXXXMSRLFRYIIGNPNK 421 E+++S++ELKALQAQINPHFL+NTLE+ WS MS LFRY I Sbjct: 356 EIVRSQSELKALQAQINPHFLYNTLESLRWSLEEKGEEELADVVVSMSELFRYTISRNVN 415 Query: 422 DEWVTLGEEMEQVQRYLKIMEMRMGDRLSWTIQLGPEEAAVPVPKLLIQPIVENAILHGV 481 D+WVTL EE ++ Y+ I++ R GDR+ W + L E V +PKLLIQP+VENA++HG Sbjct: 416 DDWVTLKEEFRHIENYMDIIKFRFGDRIKWHLSLPEEWENVKIPKLLIQPLVENAVVHGS 475 Query: 482 ESRVGSGTVSVIVAPAQRKGWTQITVQDNGPGMDADTLQSLYSALEGGPSISAKGTGIGL 541 E+R T++V V P + +I V+D+G GMD + L+++ A+ G AKG G+ L Sbjct: 476 ENRTAPCTITVAVKPVSDRH-LEIMVEDDGVGMDEERLEAVKQAMHTG---EAKGKGMAL 531 Query: 542 VNVQRRIRLYYEAEGTGVKGLNIESKLSEGTVITFEIPNNGG 583 NV++R++LYY+ E + G+ I+S ++GT +T IP NGG Sbjct: 532 YNVKKRLQLYYKKETSD--GITIDSHKNKGTKVTIRIPVNGG 571 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.318 0.136 0.384 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,243,273,166 Number of extensions: 129701209 Number of successful extensions: 379052 Number of sequences better than 1.0e-05: 1975 Number of HSP's gapped: 375544 Number of HSP's successfully gapped: 1978 Length of query: 598 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 456 Effective length of database: 1,722,912,073 Effective search space: 785647905288 Effective search space used: 785647905288 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 134 (56.2 bits)