BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0031.p (435 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3K345.1 B3K345_9BACI Histidinol dehydrogenase EC=1.1.1.23 622 e-176 B1DKX1.1 B1DKX1_9BACL Histidinol dehydrogenase EC=1.1.1.23 618 e-175 Q9K6Z2.1 HISX_BACHD Histidinol dehydrogenase EC=1.1.1.23 469 e-130 B8FP19.1 B8FP19_DESHD Histidinol dehydrogenase EC=1.1.1.23 454 e-125 C5D7P2.1 C5D7P2_9BACI Histidinol dehydrogenase EC=1.1.1.23 453 e-125 >B3K345.1 B3K345_9BACI Histidinol dehydrogenase EC=1.1.1.23 Length = 427 Score = 622 bits (1605), Expect = e-176, Method: Compositional matrix adjust. Identities = 311/426 (73%), Positives = 347/426 (81%) Query: 1 VKVQSSKEFKLQREVEYGTPEQNKAVKEIVADIKQEGDAALLRYTERFDGAALTAAGLRV 60 +KV S+++F+L+RE +YGTPEQN+ VK IV DI+ EGDAALLR+TE+ D LTA LRV Sbjct: 1 MKVVSARDFELKRENDYGTPEQNEVVKAIVRDIRSEGDAALLRHTEQLDRVRLTAGQLRV 60 Query: 61 TEEELQAAYGRVEESFVTXXXXXXXXXXXXXXXQKRNSWMDLQPDGTILGQIIRPLKRVG 120 T+EEL+AAY VE SFV QKRNSWMDLQPDG+ILGQIIRPLKRVG Sbjct: 61 TDEELKAAYDHVEPSFVKAIQAAADNIRAFHVKQKRNSWMDLQPDGSILGQIIRPLKRVG 120 Query: 121 VYVPGGKAAYPSSVLMNVIPAQIAGVPEIVMVTPPSTGGTEGIDPYILVAAAEAGVNEIY 180 VYVPGGKAAYPSSVLMNVIPAQ+AGVPEIVMVTPP+TGG +GI+PYILVAAAEAGV EIY Sbjct: 121 VYVPGGKAAYPSSVLMNVIPAQVAGVPEIVMVTPPATGGKDGINPYILVAAAEAGVTEIY 180 Query: 181 RVGGAQAIAALAFGTASIAPVDKICGPGNIYVALAKREVYGAVDIDSIAGPSEIVVXXXX 240 RVGGAQAIAALA+GT +I+PVDKICGPGNIYVALAKREVYGAV+IDS+AGPSEI V Sbjct: 181 RVGGAQAIAALAYGTETISPVDKICGPGNIYVALAKREVYGAVNIDSLAGPSEIAVLADE 240 Query: 241 XXXXXXXXXXXXSQAEHDEMASAILVTPSXXXXXXXXXXXXXXXXXLPREAIARASVDNY 300 SQAEHDEMASAILVTPS LPR IARASVD+Y Sbjct: 241 HADASYIAADLLSQAEHDEMASAILVTPSRNLGEAVAAEVERQLELLPRRDIARASVDSY 300 Query: 301 GAIIVVDSLAEGISVVNRLAPEHLEIVTEDPMGLLGSIENAGAVFLGPYSSEPVGDYFAG 360 GA+IV +SL EGI V+N LAPEHLEIVTE+PM ++G IENAGA+FLGPYSSEPVGDYFAG Sbjct: 301 GAVIVTESLQEGIEVINSLAPEHLEIVTEEPMAIVGQIENAGAIFLGPYSSEPVGDYFAG 360 Query: 361 PNHIIPTNGTARFSSPVDVDDFIKKSSLIYYSKEALLQDGATIIELARREGLEGHARAIE 420 PNHIIPTNGTARF+SPVD+DDFIKKSSLIYYSKEALL+DG I+ELARREGLEGHARAIE Sbjct: 361 PNHIIPTNGTARFASPVDLDDFIKKSSLIYYSKEALLRDGEQIMELARREGLEGHARAIE 420 Query: 421 IRLQNE 426 IRL+ E Sbjct: 421 IRLEQE 426 >B1DKX1.1 B1DKX1_9BACL Histidinol dehydrogenase EC=1.1.1.23 Length = 429 Score = 618 bits (1594), Expect = e-175, Method: Compositional matrix adjust. Identities = 303/426 (71%), Positives = 348/426 (81%) Query: 1 VKVQSSKEFKLQREVEYGTPEQNKAVKEIVADIKQEGDAALLRYTERFDGAALTAAGLRV 60 +++ +++F LQREVEYGTPEQN+ V++IV IK+EGDAALL YTE+ D L A+ LRV Sbjct: 1 MRIMKAEQFGLQREVEYGTPEQNETVRQIVEAIKEEGDAALLAYTEQLDRVRLDASSLRV 60 Query: 61 TEEELQAAYGRVEESFVTXXXXXXXXXXXXXXXQKRNSWMDLQPDGTILGQIIRPLKRVG 120 T+EE+ AAY RV+ +F+T Q RNSWMDLQPDGT+LGQI+RPLKRVG Sbjct: 61 TQEEINAAYDRVDAAFLTAIREAAVNIRVFHEKQMRNSWMDLQPDGTMLGQILRPLKRVG 120 Query: 121 VYVPGGKAAYPSSVLMNVIPAQIAGVPEIVMVTPPSTGGTEGIDPYILVAAAEAGVNEIY 180 VYVPGGKAAYPSSVLMNVIPAQ+AGVPEIVMVTPP+TGG EGIDPYILVAAAEAGV E+Y Sbjct: 121 VYVPGGKAAYPSSVLMNVIPAQVAGVPEIVMVTPPATGGKEGIDPYILVAAAEAGVKEMY 180 Query: 181 RVGGAQAIAALAFGTASIAPVDKICGPGNIYVALAKREVYGAVDIDSIAGPSEIVVXXXX 240 RVGGAQAIAALA+GTA+IAPVDKICGPGNIYVALAKR V+GAVDIDSIAGPSEIVV Sbjct: 181 RVGGAQAIAALAYGTATIAPVDKICGPGNIYVALAKRTVFGAVDIDSIAGPSEIVVLADE 240 Query: 241 XXXXXXXXXXXXSQAEHDEMASAILVTPSXXXXXXXXXXXXXXXXXLPREAIARASVDNY 300 SQAEHDEMASAILVTPS LPREAIARAS+D+Y Sbjct: 241 GANASYIAADLLSQAEHDEMASAILVTPSETLAEAVAAEVERQISTLPREAIARASIDSY 300 Query: 301 GAIIVVDSLAEGISVVNRLAPEHLEIVTEDPMGLLGSIENAGAVFLGPYSSEPVGDYFAG 360 GA+++V+S+ GI VVN+LAPEHLE++T DPM LLG IENAGA+FLGPYSSEPVGDYFAG Sbjct: 301 GAVLLVESIEAGIDVVNKLAPEHLEVLTADPMSLLGLIENAGAIFLGPYSSEPVGDYFAG 360 Query: 361 PNHIIPTNGTARFSSPVDVDDFIKKSSLIYYSKEALLQDGATIIELARREGLEGHARAIE 420 PNHIIPTNGTARFSSPV+VDDF+KKSSLIYYSKEALL++G++I+ LAR EGLE HARAI+ Sbjct: 361 PNHIIPTNGTARFSSPVNVDDFLKKSSLIYYSKEALLKNGSSIMTLARHEGLEAHARAIQ 420 Query: 421 IRLQNE 426 IRL+ E Sbjct: 421 IRLEQE 426 >Q9K6Z2.1 HISX_BACHD Histidinol dehydrogenase EC=1.1.1.23 Length = 424 Score = 469 bits (1207), Expect = e-130, Method: Compositional matrix adjust. Identities = 244/416 (58%), Positives = 294/416 (70%), Gaps = 4/416 (0%) Query: 11 LQREVEYGTPEQNKAVKEIVADIKQEGDAALLRYTERFDGAALTAAGLRVTEEELQAAYG 70 L+R+++ GT Q AV I+A ++++GD AL T++FDGA LT LRV + E++AAY Sbjct: 12 LKRDLDTGTDMQQNAVHSIIAQVREQGDQALFTLTKQFDGADLTT--LRVQQAEIEAAYR 69 Query: 71 RVEESFVTXXXXXXXXXXXXXXXQKRNSWMDLQPDGTILGQIIRPLKRVGVYVPGGKAAY 130 +EE + QKRNSWM + DGTILGQ I PL VG+YVPGGKAAY Sbjct: 70 EMEEPVLQAIGEAIENIRDFHERQKRNSWMTTKSDGTILGQKITPLDSVGLYVPGGKAAY 129 Query: 131 PSSVLMNVIPAQIAGVPEIVMVTPPSTGGTEGIDPYILVAAAEAGVNEIYRVGGAQAIAA 190 PSS++MNVIPAQ+AGV IV+V+PP G+ I +LV AAE GV I +VGGAQAIAA Sbjct: 130 PSSIMMNVIPAQVAGVQNIVIVSPPQKDGS--IPAGVLVTAAELGVKTILKVGGAQAIAA 187 Query: 191 LAFGTASIAPVDKICGPGNIYVALAKREVYGAVDIDSIAGPSEIVVXXXXXXXXXXXXXX 250 LA+GT S+ VDKI GPGNIYVALAKR V+G VDID IAGPSEIVV Sbjct: 188 LAYGTESVPAVDKITGPGNIYVALAKRAVFGHVDIDMIAGPSEIVVLADERANPRYIAAD 247 Query: 251 XXSQAEHDEMASAILVTPSXXXXXXXXXXXXXXXXXLPREAIARASVDNYGAIIVVDSLA 310 SQAEHDE ASAILVTPS LP+ IA AS+ +YGAI V ++L Sbjct: 248 LLSQAEHDERASAILVTPSRALAEEVAVEVDQQLTTLPKREIAAASIRDYGAIYVTETLE 307 Query: 311 EGISVVNRLAPEHLEIVTEDPMGLLGSIENAGAVFLGPYSSEPVGDYFAGPNHIIPTNGT 370 E +SVVN LAPEHLEI+ E+PM LG I +AGA+FLGPYSSEPVGDYFAGPNH++PTNGT Sbjct: 308 EAVSVVNELAPEHLEILAEEPMSFLGKIRHAGAIFLGPYSSEPVGDYFAGPNHVLPTNGT 367 Query: 371 ARFSSPVDVDDFIKKSSLIYYSKEALLQDGATIIELARREGLEGHARAIEIRLQNE 426 ARFSSP++VDDF+KKSS+I YSK ALL++GA I LAR EGLE HARAI+IRL++E Sbjct: 368 ARFSSPLNVDDFVKKSSIISYSKAALLENGAKISALARLEGLEAHARAIDIRLEDE 423 >B8FP19.1 B8FP19_DESHD Histidinol dehydrogenase EC=1.1.1.23 Length = 426 Score = 454 bits (1167), Expect = e-125, Method: Compositional matrix adjust. Identities = 227/397 (57%), Positives = 283/397 (71%), Gaps = 2/397 (0%) Query: 26 VKEIVADIKQEGDAALLRYTERFDGAALTAAGLRVTEEELQAAYGRVEESFVTXXXXXXX 85 V EI+++IK+EGD+AL TE+FDG L +GLRV EEL AY +V+E F+ Sbjct: 29 VAEILSEIKKEGDSALYALTEKFDGVDLRPSGLRVRAEELVKAYSQVDEEFLAALRLAKE 88 Query: 86 XXXXXXXXQKRNSWMDLQPDGTILGQIIRPLKRVGVYVPGGKAAYPSSVLMNVIPAQIAG 145 QKR SW+D Q DG+ILGQ++ PLKRVG+YVPGG AAYPSSVLMN +PA +AG Sbjct: 89 KITSYHEKQKRTSWLDAQEDGSILGQLLLPLKRVGIYVPGGTAAYPSSVLMNAVPAVVAG 148 Query: 146 VPEIVMVTPPSTGGTEGIDPYILVAAAEAGVNEIYRVGGAQAIAALAFGTASIAPVDKIC 205 V EIVMV+PP G+ + P +LVAAAEAGV EIY+VGGAQAIAALAFGT I+PVDKI Sbjct: 149 VEEIVMVSPPRKDGS--LLPEVLVAAAEAGVTEIYKVGGAQAIAALAFGTGEISPVDKIT 206 Query: 206 GPGNIYVALAKREVYGAVDIDSIAGPSEIVVXXXXXXXXXXXXXXXXSQAEHDEMASAIL 265 GPGNIYV LAK++V+G VDID +AGPSEI++ SQAEHD +AS+IL Sbjct: 207 GPGNIYVTLAKKQVFGTVDIDMLAGPSEILILADESAQPEELAADLLSQAEHDPLASSIL 266 Query: 266 VTPSXXXXXXXXXXXXXXXXXLPREAIARASVDNYGAIIVVDSLAEGISVVNRLAPEHLE 325 V+P LPR+ IARAS + YGA I+V LAEG+++VN++APEH E Sbjct: 267 VSPDRKVLEETVAEVERQLKLLPRQDIARASWETYGAAILVKDLAEGMNLVNQIAPEHFE 326 Query: 326 IVTEDPMGLLGSIENAGAVFLGPYSSEPVGDYFAGPNHIIPTNGTARFSSPVDVDDFIKK 385 +V ++P LG + NAGAVFLG +S EPVGDYFAGPNH++PT GTARF SP++VD F+KK Sbjct: 327 LVIKEPYSWLGRVRNAGAVFLGRFSPEPVGDYFAGPNHVLPTGGTARFYSPLNVDTFMKK 386 Query: 386 SSLIYYSKEALLQDGATIIELARREGLEGHARAIEIR 422 S+I YS++AL +DG I LAR+EGLE HARA+E R Sbjct: 387 VSVISYSEKALQRDGKHIAHLARKEGLEAHARAVEAR 423 >C5D7P2.1 C5D7P2_9BACI Histidinol dehydrogenase EC=1.1.1.23 Length = 422 Score = 453 bits (1166), Expect = e-125, Method: Compositional matrix adjust. Identities = 238/415 (57%), Positives = 285/415 (68%), Gaps = 4/415 (0%) Query: 11 LQREVEYGTPEQNKAVKEIVADIKQEGDAALLRYTERFDGAALTAAGLRVTEEELQAAYG 70 L+R +E GT EQ V EI+AD++ GD AL YTE+FDG L + L VT EE++ AY Sbjct: 12 LRRTIESGTEEQRSKVLEIIADVRARGDEALKSYTEKFDGVRLDS--LCVTNEEIERAYQ 69 Query: 71 RVEESFVTXXXXXXXXXXXXXXXQKRNSWMDLQPDGTILGQIIRPLKRVGVYVPGGKAAY 130 V + QKR SW+ + DGT+LGQ I PL VG+YVPGG AAY Sbjct: 70 NVSAEVLRIIQEAAENIRDYHERQKRESWIMTKEDGTMLGQKITPLDAVGLYVPGGTAAY 129 Query: 131 PSSVLMNVIPAQIAGVPEIVMVTPPSTGGTEGIDPYILVAAAEAGVNEIYRVGGAQAIAA 190 PSSVLMNVIPAQ+AGV IV+ +PP+ GT + +LVAA E GV EIY+VGGAQAIAA Sbjct: 130 PSSVLMNVIPAQVAGVKRIVITSPPNKDGT--LPAGVLVAANELGVKEIYKVGGAQAIAA 187 Query: 191 LAFGTASIAPVDKICGPGNIYVALAKREVYGAVDIDSIAGPSEIVVXXXXXXXXXXXXXX 250 LA+GT +I PVDKI GPGNIYVALAKREV+G V ID IAGPSEIVV Sbjct: 188 LAYGTETIRPVDKIFGPGNIYVALAKREVFGQVAIDMIAGPSEIVVLADETAKANEIAAD 247 Query: 251 XXSQAEHDEMASAILVTPSXXXXXXXXXXXXXXXXXLPREAIARASVDNYGAIIVVDSLA 310 SQAEHDE ASAILVTPS LPR+AIA AS++NYGAI V ++LA Sbjct: 248 LLSQAEHDERASAILVTPSMKLALAVAREVEKQLETLPRKAIASASLENYGAIYVTETLA 307 Query: 311 EGISVVNRLAPEHLEIVTEDPMGLLGSIENAGAVFLGPYSSEPVGDYFAGPNHIIPTNGT 370 E + VVN LAPEHLE++T +PM LLG I +AGA+FLG +SSEPVGDYFAGPNH++PTNGT Sbjct: 308 EAVEVVNELAPEHLEVMTAEPMQLLGQIRHAGAIFLGRFSSEPVGDYFAGPNHVLPTNGT 367 Query: 371 ARFSSPVDVDDFIKKSSLIYYSKEALLQDGATIIELARREGLEGHARAIEIRLQN 425 ARFSS + VD+F+KKSS+I+YS+ AL Q+ I AR EGLE HARA+E R + Sbjct: 368 ARFSSGLSVDEFVKKSSIIFYSEPALKQNAEKIAAFARLEGLEAHARAVEERFKK 422 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.314 0.134 0.374 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 2,325,413,850 Number of extensions: 91930506 Number of successful extensions: 191840 Number of sequences better than 1.0e-05: 1521 Number of HSP's gapped: 185941 Number of HSP's successfully gapped: 1531 Length of query: 435 Length of database: 3,060,696,203 Length adjustment: 139 Effective length of query: 296 Effective length of database: 1,751,175,118 Effective search space: 518347834928 Effective search space used: 518347834928 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 133 (55.8 bits)