BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0028.p (245 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B3K348.1 B3K348_9BACI 1-(5-phosphoribosyl)-5-[(5-phosphoribosyla... 355 2e-96 C0Z6P5.1 HIS4_BREBN 1-(5-phosphoribosyl)-5-[(5-phosphoribosylami... 308 3e-82 A8FHR0.1 HIS4_BACP2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylami... 293 9e-78 B4AGN8.1 B4AGN8_BACPU 1-(5-phosphoribosyl)-5-[(5-phosphoribosyla... 292 2e-77 Q9K6Z5.1 HIS4_BACHD 1-(5-phosphoribosyl)-5-[(5-phosphoribosylami... 291 3e-77 >B3K348.1 B3K348_9BACI 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase EC=5.3.1.16 Length = 227 Score = 355 bits (910), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 175/215 (81%), Positives = 190/215 (88%) Query: 25 YNQETIYNDSPVSVAKSWEEQGGKFIHLVDLDGAKAGHPVNDAIIGAIAKNAGVPVQVGG 84 YNQET+YND+P+ VAKSWEEQGG FIHLVDLDGAKAG PVND IIG IA + VPVQVGG Sbjct: 9 YNQETVYNDNPLEVAKSWEEQGGTFIHLVDLDGAKAGQPVNDGIIGKIASSVQVPVQVGG 68 Query: 85 GLRTLADVEKLLGLGVSRVIIGTAAINDHAFTEAVLAKYGDKVAIGIDARGGYVATHGWL 144 GLRTLADVE+LL LGVSRVIIGTAAI D FTEAVL KYGDKVAIGIDAR GYVAT GWL Sbjct: 69 GLRTLADVERLLSLGVSRVIIGTAAIEDRVFTEAVLGKYGDKVAIGIDARNGYVATRGWL 128 Query: 145 NTSEVRAEDLAKELASKGAETFIYTDISRDGMMQGPNIEGILSMAATSGKTVIASGGVTS 204 TSEV+AE LAKELA+KGAETFI+TDISRDGMMQGPN+E I+S+A SG++VIASGGVT Sbjct: 129 ETSEVQAEVLAKELAAKGAETFIFTDISRDGMMQGPNVEAIVSLAKASGRSVIASGGVTK 188 Query: 205 LDDLLRLSVHSGSGIGGAIVGKALYTGNIDLAEAL 239 LDDLL LS HSG G+GGAIVGKALYTGNIDL EA+ Sbjct: 189 LDDLLALSAHSGDGVGGAIVGKALYTGNIDLKEAI 223 >C0Z6P5.1 HIS4_BREBN 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase EC=5.3.1.16 Length = 249 Score = 308 bits (789), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 150/243 (61%), Positives = 184/243 (75%) Query: 3 SFIVYPAIDIRDGKCVRLQQGDYNQETIYNDSPVSVAKSWEEQGGKFIHLVDLDGAKAGH 62 SFIVYPAIDIR GKCVRL QGDY QET+Y DSP+++AK W EQG ++HLVDLDGAK G Sbjct: 2 SFIVYPAIDIRGGKCVRLFQGDYGQETVYADSPLAMAKRWVEQGASWVHLVDLDGAKEGK 61 Query: 63 PVNDAIIGAIAKNAGVPVQVGGGLRTLADVEKLLGLGVSRVIIGTAAINDHAFTEAVLAK 122 P N AII IA++ VPVQVGGG+RT + L GV+RVI+GTAAI D FT+ +L Sbjct: 62 PANAAIIKEIARSIPVPVQVGGGIRTEEQIADYLEAGVARVIVGTAAIEDEPFTKRILQN 121 Query: 123 YGDKVAIGIDARGGYVATHGWLNTSEVRAEDLAKELASKGAETFIYTDISRDGMMQGPNI 182 GDK+AIG+D R G VAT GWL T++V+A +LAK L + GAETFIYTDI+RDG M GPN+ Sbjct: 122 DGDKIAIGLDCRNGLVATRGWLTTTDVQATELAKRLVTYGAETFIYTDIARDGTMTGPNV 181 Query: 183 EGILSMAATSGKTVIASGGVTSLDDLLRLSVHSGSGIGGAIVGKALYTGNIDLAEALQAL 242 E I ++A +GK+VIASGGV+ LDDLL L+ H+ G+ GAIVGKALYT L EALQ + Sbjct: 182 EEIAALAMATGKSVIASGGVSQLDDLLTLATHASDGVSGAIVGKALYTDAFTLEEALQRM 241 Query: 243 DSK 245 + + Sbjct: 242 EGR 244 >A8FHR0.1 HIS4_BACP2 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase EC=5.3.1.16 Length = 245 Score = 293 bits (750), Expect = 9e-78, Method: Compositional matrix adjust. Identities = 140/243 (57%), Positives = 187/243 (76%) Query: 1 MSSFIVYPAIDIRDGKCVRLQQGDYNQETIYNDSPVSVAKSWEEQGGKFIHLVDLDGAKA 60 MS F +YPAID+R+GKCVRL QGDY+QETIY DSP+ +A + +G K+IHLVDLDGAKA Sbjct: 1 MSEFTLYPAIDMRNGKCVRLVQGDYDQETIYGDSPLDMATRFANEGAKWIHLVDLDGAKA 60 Query: 61 GHPVNDAIIGAIAKNAGVPVQVGGGLRTLADVEKLLGLGVSRVIIGTAAINDHAFTEAVL 120 G+ VN + AIA + V VQ+GGG+RT DV + GV+RVI+G++A+++ AF + +L Sbjct: 61 GNRVNHEHVLAIASSLDVKVQIGGGIRTEEDVAFYINNGVARVILGSSAVSNSAFVKKML 120 Query: 121 AKYGDKVAIGIDARGGYVATHGWLNTSEVRAEDLAKELASKGAETFIYTDISRDGMMQGP 180 A+YG+K+AIGIDAR G+V+T GWL TS+V+AEDL KELA +GAE FI+TDI DGM+ GP Sbjct: 121 AQYGEKIAIGIDARNGFVSTEGWLETSKVKAEDLGKELAKEGAEVFIFTDIQMDGMLAGP 180 Query: 181 NIEGILSMAATSGKTVIASGGVTSLDDLLRLSVHSGSGIGGAIVGKALYTGNIDLAEALQ 240 N+E + +A +GK VIASGG++S+ DL +LS +G+ GAI+GKALYT LAEA++ Sbjct: 181 NVESTVRLAEATGKQVIASGGISSVADLQKLSAQKQTGVSGAIIGKALYTERFTLAEAIE 240 Query: 241 ALD 243 LD Sbjct: 241 GLD 243 >B4AGN8.1 B4AGN8_BACPU 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase EC=5.3.1.16 Length = 245 Score = 292 bits (747), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 141/243 (58%), Positives = 186/243 (76%) Query: 1 MSSFIVYPAIDIRDGKCVRLQQGDYNQETIYNDSPVSVAKSWEEQGGKFIHLVDLDGAKA 60 MS F +YPAID+R+GKCVRL QGDY+QETIY DSP+ +A + +G K+IHLVDLDGAKA Sbjct: 1 MSDFTLYPAIDMRNGKCVRLVQGDYDQETIYGDSPLDMATRFANEGAKWIHLVDLDGAKA 60 Query: 61 GHPVNDAIIGAIAKNAGVPVQVGGGLRTLADVEKLLGLGVSRVIIGTAAINDHAFTEAVL 120 G VN + AIA + V VQ+GGG+RT DV + GV+RVI+G++A+++ AF + +L Sbjct: 61 GSRVNHEHVLAIASSLDVNVQIGGGIRTEEDVAFYINNGVARVILGSSAVSNPAFVKKML 120 Query: 121 AKYGDKVAIGIDARGGYVATHGWLNTSEVRAEDLAKELASKGAETFIYTDISRDGMMQGP 180 A+YG+K+AIGIDAR G+V+T GWL TS+V+AEDL KELA +GAE FI+TDI DGM+ GP Sbjct: 121 AQYGEKIAIGIDARNGFVSTEGWLETSKVKAEDLGKELAKEGAEVFIFTDIQMDGMLAGP 180 Query: 181 NIEGILSMAATSGKTVIASGGVTSLDDLLRLSVHSGSGIGGAIVGKALYTGNIDLAEALQ 240 N+E + +A +GK VIASGG++S+ DL +LS SG+ GAI+GKALYT LAEA++ Sbjct: 181 NVESTIRLAEATGKQVIASGGISSVADLQKLSAQKQSGVSGAIIGKALYTERFTLAEAIE 240 Query: 241 ALD 243 LD Sbjct: 241 GLD 243 >Q9K6Z5.1 HIS4_BACHD 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase EC=5.3.1.16 Length = 244 Score = 291 bits (745), Expect = 3e-77, Method: Compositional matrix adjust. Identities = 144/241 (59%), Positives = 180/241 (74%), Gaps = 1/241 (0%) Query: 1 MSSFIVYPAIDIRDGKCVRLQQGDYNQETIYNDSPVSVAKSWEEQGGKFIHLVDLDGAKA 60 M+ FI+YPAID+RDGKCVRL QGDYNQET+Y DSP ++AKS+ EQG ++IH+VDLDGAKA Sbjct: 1 MAKFIIYPAIDMRDGKCVRLVQGDYNQETVYGDSPFTMAKSFAEQGAEWIHMVDLDGAKA 60 Query: 61 GHPVNDAIIGAIAKNAGVPVQVGGGLRTLADVEKLLGLGVSRVIIGTAAINDHAFTEAVL 120 +N + +A V VQVGGG+RT D+ L G+SRVI+G+ A+N+ AFT+ +L Sbjct: 61 KERMNHEHVVKVATELDVNVQVGGGIRTAEDIAYYLDRGISRVILGSVAVNNPAFTKEML 120 Query: 121 AKY-GDKVAIGIDARGGYVATHGWLNTSEVRAEDLAKELASKGAETFIYTDISRDGMMQG 179 KY G+K+AIG+DAR GYVAT GWL TS V+AE L +ELA GAE FI+TDISRDGM+ G Sbjct: 121 QKYGGEKIAIGLDARDGYVATEGWLETSSVKAETLGQELARHGAEVFIFTDISRDGMLSG 180 Query: 180 PNIEGILSMAATSGKTVIASGGVTSLDDLLRLSVHSGSGIGGAIVGKALYTGNIDLAEAL 239 PN E I+ +A +GK VIASGGV+SL DL L +GI GAIVGKALYT L +AL Sbjct: 181 PNTEAIVQLAKATGKQVIASGGVSSLQDLDALRNEKQNGIAGAIVGKALYTNQFTLEDAL 240 Query: 240 Q 240 + Sbjct: 241 K 241 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.315 0.135 0.382 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 1,462,407,578 Number of extensions: 62596419 Number of successful extensions: 161608 Number of sequences better than 1.0e-05: 2640 Number of HSP's gapped: 156218 Number of HSP's successfully gapped: 2640 Length of query: 245 Length of database: 3,060,696,203 Length adjustment: 132 Effective length of query: 113 Effective length of database: 1,817,122,223 Effective search space: 205334811199 Effective search space used: 205334811199 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 129 (54.3 bits)