BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0008.p (600 letters) Database: pfamseq 9,421,015 sequences; 3,060,696,203 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value C5EE53.1 C5EE53_9FIRM Histidine kinase internal region 282 8e-74 B8I3I8.1 B8I3I8_CLOCE Putative sensor with HAMP domain 212 8e-53 A8RMQ3.1 A8RMQ3_9CLOT Putative uncharacterized protein 209 6e-52 C1I2X2.1 C1I2X2_9CLOT Multi-sensor signal transduction histidine... 208 1e-51 A6M1Q9.1 A6M1Q9_CLOB8 Multi-sensor signal transduction histidine... 207 2e-51 >C5EE53.1 C5EE53_9FIRM Histidine kinase internal region Length = 599 Score = 282 bits (721), Expect = 8e-74, Method: Compositional matrix adjust. Identities = 164/561 (29%), Positives = 300/561 (53%), Gaps = 16/561 (2%) Query: 37 SSRQLKENAFYALSDTTHQTALFMNDKFMTIFEQLVRLERND---ALGNILSGEGQTAEQ 93 S Q+ E++ + ++ Q+ ++ + + E+ +E + +L ++S E + Sbjct: 44 SYNQVTESSRANMLNSLTQSTSVLDSRMADLMERFQYIENSSDMLSLALVMSQENVDRAK 103 Query: 94 HRYDDLIELHKQLDDVYHSYFQMIDSIFVAFNNGRSFNLQQEYVPRKVHIDLGDWLKRYN 153 +Y I L K +DD + S +DS+ + FN+ R + E +P K+ + W Y Sbjct: 104 GQY--YINLRKSIDDQFVSSGSFLDSVIIDFNDSRFRMYRCEDIPVKIDFNYDAW---YG 158 Query: 154 TSKKGYYWLNSHKDTVFETVE------QRKVMSSFKIIGTESSPVSGIVLINLRESYFLD 207 ++ Y W H DT+F+ + +V S +++ G P G ++ N+RES F D Sbjct: 159 RNQSIYNWSFLHDDTIFQVTDAENNRKNNRVFSLYRLYGKPGQPGRGGIVFNIRESMFRD 218 Query: 208 IMENVNISPGGTLVLISPEGALFSKELDKGYELSGDTITALRNXXXXXXXXXXXXKEGRK 267 ++ +IS G + LI + K++D+ Y LS ++ L+ G++ Sbjct: 219 MLTIPDISENGYVALIHDGSLIRYKDVDESYTLSEQSLRQLQQMADVSAGIKVKSVSGQE 278 Query: 268 MAIAYNTLPLNHWVLAAVVPEKDILEGANRIKYITLVIMVFXXXXXXXXXXXXXRNLSNP 327 M + L N W++AA++P ++ ++ M+ R + P Sbjct: 279 MMVYTRHLKTNGWLVAALLPTNEMFHDVRTMQNSIHFTMIAVIVCSVLACVVLSRLIVLP 338 Query: 328 LRYLSKQVKRFERGDFTVSFALDQHNEMGVLARGLSGLLASVVQLLDKVRSEQEKKRQIE 387 ++ L+ V E + + E+ +L+ ++ LL+ V QL+++V+ EQEKKR+ E Sbjct: 339 IKRLTDTVS-VEDVTSIANVSSGGAREIQILSDKINELLSRVRQLIEQVKEEQEKKREAE 397 Query: 388 LQAMQAQIQPHFLYNTLSSIKHLIDMNERQRASTMVSALTSYFRISISKGREIIPVREEM 447 L MQ QI PHFLYNTL S++ L +++E + AS MV AL+++FR +S+G ++I + E+ Sbjct: 398 LSLMQEQINPHFLYNTLYSVQQLCELDESKEASAMVLALSNFFRTGLSRGEDVITIDTEI 457 Query: 448 EHVRSYLMILNIRYSQEFDYEINVADEXXXXXXXXXXXQPIVENAIYHGIKNKHGQGHLS 507 HV++YL+I +++Y +F+YEI +A + QP+VENA++HGI+N+ G+G ++ Sbjct: 458 NHVKNYLVIQHMKYGDKFEYEIEIAPDIRDCRILKLTLQPLVENALHHGIQNQAGKGMIT 517 Query: 508 VTGYREGDNAVFEVYDNGHGISEAKLSQLRASLQSDTAAYEAITYGLWNAHMRIVLHFGS 567 +TG REG +FEV D G G++ +L Q+R S+ + Y +++GL N + R++L++ Sbjct: 518 ITGKREGGRILFEVRDTGAGMASERLEQVRKSMNQE-EGYSQVSFGLRNVYSRLMLYYDG 576 Query: 568 SYGLQLDSEEGVYTRVKVYLP 588 GL+++S +G T +KVY+P Sbjct: 577 EAGLEIESVQGRGTVIKVYIP 597 >B8I3I8.1 B8I3I8_CLOCE Putative sensor with HAMP domain Length = 597 Score = 212 bits (540), Expect = 8e-53, Method: Compositional matrix adjust. Identities = 154/588 (26%), Positives = 278/588 (47%), Gaps = 27/588 (4%) Query: 10 IQSKLLICFLPILVLSVVLTGFFSYLSSSRQLKENAFYALSDTTHQTALFMNDKFMTIFE 69 I+SK+ ICFL + ++ ++L G SY + L +N + S+ + + +++ E Sbjct: 24 IRSKMTICFLALGLVPILLFGIISYHLYLQNLHKNV-TSYSEQVIERVDKNLETYISDIE 82 Query: 70 QLVRLERNDALGNI--LSGEGQTAEQHRYDDLIELHKQLDDVYHSYFQMIDSIFVAFNNG 127 ++RL+ N L+ G +Y + + + D V ++D F++ ++G Sbjct: 83 NIMRLKSNYYFQQYSKLNEAGDIEGNRKY--TVRIWETFDSVKQMKTDLVDIRFIS-SSG 139 Query: 128 RSFNLQQEYVPRKVHIDLGDWLKRYNTSKKGYYWLNSHKDTVFE------TVEQRKVMSS 181 + + Y W+ N + Y L + K ++ +KV S Sbjct: 140 STISCYGRY-----------WVDVSN--EPLYRELINKKSSIVAIQPPHLNALNKKVFSI 186 Query: 182 FKIIGTESSPVSGIVLINLRESYFLDIMENVNISPGGTLVLISPEGALFSKELDKGYELS 241 + + + GI+ I++ ++ I ++ + G + +FS + + S Sbjct: 187 GQAVNRNINGNIGIMAIDIDINFLKKICSDIKLGETGFVFFEKDGKVVFSPQSSDKHGYS 246 Query: 242 GDTITALRNXXXXXXXXXXXXKEGRKMAIAYNTLPLNHWVLAAVVPEKDILEGANRIKYI 301 + I + I Y T + W + V PE ++ G + + Sbjct: 247 NNIIQNPK-LMDSENGSFIDSINNTNYIITYKTSAITGWKIVGVSPEAEMTSGVIMLSKV 305 Query: 302 TLVIMVFXXXXXXXXXXXXXRNLSNPLRYLSKQVKRFERGDFTVSFALDQHNEMGVLARG 361 ++ L+NP+R L +K+ D ++ + +E+G LA Sbjct: 306 FFWLITLIIIIILLLTIYLTSVLTNPMRKLRSTMKQASENDLSIYADIRTRDEIGQLASS 365 Query: 362 LSGLLASVVQLLDKVRSEQEKKRQIELQAMQAQIQPHFLYNTLSSIKHLIDMNERQRAST 421 + ++ + +L+DKV+ +Q+K R +E++AMQ I+PHF+YNTL SI L++ N A Sbjct: 366 FNKMMNQIRELMDKVKEDQQKIRVMEMKAMQELIKPHFIYNTLDSIIGLLEQNRNDDAID 425 Query: 422 MVSALTSYFRISISKGREIIPVREEMEHVRSYLMILNIRYSQEFDYEINVADEXXXXXXX 481 ++ +L +FR S+S GRE++ +REE++H+RSYLMI R+S +FDY + D Sbjct: 426 IIDSLGKFFRTSLSHGREVVLIREEIDHIRSYLMIQQFRFSNKFDYLFELDDVIYNFKTV 485 Query: 482 XXXXQPIVENAIYHGIKNKHGQGHLSVTGYREGDNAVFEVYDNGHGISEAKLSQLRASLQ 541 QP+VEN+IYHGI++ +G + + GY + D +FE+ DNG GI E K++QL + Sbjct: 486 KLILQPLVENSIYHGIRSLDKKGLIVINGYLKDDQIIFEISDNGEGIGEEKIAQLNRIMS 545 Query: 542 SDTAAYEAITY-GLWNAHMRIVLHFGSSYGLQLDSEEGVYTRVKVYLP 588 + + Y G+ N + RI L+FGS YGL+ S+ V T+V V +P Sbjct: 546 GEEEVEDQNMYFGIRNVNERIKLNFGSDYGLKYQSKVSVGTKVVVNIP 593 >A8RMQ3.1 A8RMQ3_9CLOT Putative uncharacterized protein Length = 620 Score = 209 bits (532), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 152/598 (25%), Positives = 275/598 (45%), Gaps = 19/598 (3%) Query: 10 IQSKLLICFLPILVLSVVLTGFFSYLSSSRQLKENAFYALSDTTHQTALFMNDKFMTIFE 69 ++ K+++ F VVLTG Y ++ ++ E A +N+ F+ F+ Sbjct: 29 LKEKMILSFAAASTGIVVLTGALHYYMTASRILEEAEATTVQMVGNACQDINELFLQTFQ 88 Query: 70 QLVRLERNDALGNILSGEGQTAEQHRYDDLIELHKQLDDVYHSYFQMIDSIFVAFNNGRS 129 + N ++ ++ + + ++ DL + + V SY + I ++V +NG Sbjct: 89 VCSAMNDNISMQKLIRRQFSSIKEMYSHDLEGSMEMM--VLPSYNRDIFGVYVLGDNGGR 146 Query: 130 FNLQQEYV----PRKVHIDLGDWLKRYNTSKKGYYWLNSHKDT-VFETVEQRKVMSSFKI 184 + PR DW + + + + W H+++ V T V Sbjct: 147 YKSNSSSFLVSDPRDT-----DWYRIIHATGQAQ-WFPPHENSYVVSTPYTSYVSMGIPF 200 Query: 185 IGTESSPVSGIVLINLRESYFLDIMENVNISPGGTLVLISPEGALFSKELDKGYELSGDT 244 I + G+VL ++ DI +S G + L+ + + +G D Sbjct: 201 IDKATGRTKGVVLADIDSDKLSDIAARA-VSGAGDVFLMDERNRIMNLTAGEGPWKDRDG 259 Query: 245 ITALR-----NXXXXXXXXXXXXKEGRKMAIAYNTLPLNHWVLAAVVPEKDILEGANRIK 299 + R N + + + Y TL W + V+P+ I IK Sbjct: 260 VEKARRMVEENLSEIPEYGVSHVLKDKGQLVVYQTLNQTDWKIVGVIPKASITRSVEYIK 319 Query: 300 YITLVIMVFXXXXXXXXXXXXXRNLSNPLRYLSKQVKRFERGDFTVSFALDQHNEMGVLA 359 + ++++ +++ PL L K +++ G+ S ++ +E+GVL Sbjct: 320 VLMIMLLALAVVISMILSEIVADSVTRPLFTLVKAMEQVCAGNLETSVETERGDEIGVLY 379 Query: 360 RGLSGLLASVVQLLDKVRSEQEKKRQIELQAMQAQIQPHFLYNTLSSIKHLIDMNERQRA 419 + + + L+D + EQEK R+ EL+A+QAQI PHFLYNTL SI + M + + + Sbjct: 380 DSFNHMTGEMRNLIDTIYREQEKLRREELKALQAQINPHFLYNTLDSIIWSLRMRQVEES 439 Query: 420 STMVSALTSYFRISISKGREIIPVREEMEHVRSYLMILNIRYSQEFDYEINVADEXXXXX 479 M++ALT +F+IS+SKGR+II + EE++H++SYL I + RY ++FDY+I+V Sbjct: 440 IEMLTALTDFFKISLSKGRDIITIEEEVKHIKSYLSIQHRRYQEKFDYDIHVDPSILSCR 499 Query: 480 XXXXXXQPIVENAIYHGIKNKHGQGHLSVTGYREGDNAVFEVYDNGHGISEAKLSQLRAS 539 QP+VENAIYHGIK +G++ + + + + + +V D G G+ E +L Sbjct: 500 TPKLILQPVVENAIYHGIKPMEEKGYIYIHIFPQEGDVILQVQDTGMGMDEDTCRRLNRE 559 Query: 540 LQSDTAAYEAITYGLWNAHMRIVLHFGSSYGLQLDSEEGVYTRVKVYLPYANEAKGES 597 L + ++ + YG+ N + +I + +GS YG+ ++S G T V + + EA ES Sbjct: 560 LDTISSDQQGTGYGVRNVNDKIKIVYGSKYGVTIESAMGEGTVVTLRIGKKGEASDES 617 >C1I2X2.1 C1I2X2_9CLOT Multi-sensor signal transduction histidine kinase Length = 597 Score = 208 bits (529), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 128/404 (31%), Positives = 202/404 (50%), Gaps = 6/404 (1%) Query: 187 TESSPVSG-IVLINLRESYFLDIMENVNISPGGTLVLISPEGALFSKELDKGYELSGDTI 245 TES ++G ++L+++ S I +NV++ G + LI +G + + + D I Sbjct: 186 TESGRINGGVLLVDMNFSGIEQICKNVDMGKNGYVYLIDRDGEIIYHP--RQQLIYSDLI 243 Query: 246 TALRNXXXXXXXXXXXXK-EGRKMAIAYNTLPLNHWVLAAVVPEKDILEGANRIKYITLV 304 K EG K + T+ W + A+ P DI I+ + Sbjct: 244 KENNYEAAKYEDGNHVEKFEGDKRLVTVKTVGYTGWKIVAISPMTDITADYYEIRVFAIF 303 Query: 305 IMVFXXXXXXXXXXXXXRNLSNPLRYLSKQVKRFERGDFTVSFALDQHNEMGVLARGLSG 364 +M F ++NP++ L K V FE G ++ + E+ L + + Sbjct: 304 MMFFAIFTLISINMFVSSRIANPIKELEKSVNEFENGVVNLNISESGSYEIQHLGKAIKS 363 Query: 365 LLASVVQLLDKVRSEQEKKRQIELQAMQAQIQPHFLYNTLSSIKHLIDMNERQRASTMVS 424 ++ + L++ + +EQE KR+ EL A+QAQI PHFLYNTL SI +I+ A MV+ Sbjct: 364 MVKQMNMLMENIMNEQEAKRKSELNALQAQINPHFLYNTLDSIIWMIENENYDGAIVMVT 423 Query: 425 ALTSYFRISISKGREIIPVREEMEHVRSYLMILNIRYSQEFDYEINVADEXXXXXXXXXX 484 AL +FRIS+SKG+ +I V++E+EH R YL I NIRY +F Y+I +E Sbjct: 424 ALARFFRISLSKGKNVITVKDELEHARYYLTIQNIRYKNKFTYDIKAEEEVLNLTSIKLI 483 Query: 485 XQPIVENAIYHGIKNKHGQGHLSVTGYREGDNAVFEVYDNGHGISEAKLSQLRASLQSDT 544 QP++ENAIYHG++ G G + V Y + D ++ DNG G+ + +L + Sbjct: 484 IQPLIENAIYHGMEYMSGDGDILVQAYLKNDELYIDIIDNGLGMPQEVADKLLTNENGVQ 543 Query: 545 AAYEAITYGLWNAHMRIVLHFGSSYGLQLDSEEGVYTRVKVYLP 588 I GL N H RI L+FG SYGL++ SE T +++++P Sbjct: 544 KKGSGI--GLRNVHERIKLYFGDSYGLEIYSEPDEGTTIRIHMP 585 >A6M1Q9.1 A6M1Q9_CLOB8 Multi-sensor signal transduction histidine kinase Length = 602 Score = 207 bits (527), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 142/467 (30%), Positives = 222/467 (47%), Gaps = 39/467 (8%) Query: 145 LGDWLKRYNTSKKGYYWLNSHKDTVF--ETVEQRKVMSSFKII--GTESSPVSGIVLINL 200 + DW + K+ ++ H +F + R V+S + I SG++L+++ Sbjct: 144 VSDWFTKAIDKKENLHFSTPHVQNLFVDPDYKYRWVVSLSRAIELTNNKKTTSGVLLVDI 203 Query: 201 RESYFLDIMENVNISPGGTLVLISPEGAL---------FSKELDKGYEL-----SGDTIT 246 S I +N NI G + L+ EG + +S +D+ ++ G+ I Sbjct: 204 NFSGIEQICKNANIGKSGYVYLVDREGEIIYHPRQQLIYSDLIDENNKIEAAYDDGNHIE 263 Query: 247 ALRNXXXXXXXXXXXXKEGRKMAIAYNTLPLNHWVLAAVVPEKDILEGANRIKYITLVIM 306 R G K + T+ W + + P DI ++ + IM Sbjct: 264 TFR---------------GEKRLVTVKTVGYTGWKIVGITPMLDITSDYYQMSIFAVFIM 308 Query: 307 VFXXXXXXXXXXXXXRNLSNPLRYLSKQVKRFERGDFTVSFALDQHNEMGVLARGLSGLL 366 F ++NP+R L K VK+ E G V ++ E+ L + + ++ Sbjct: 309 SFAIFILVFLNMFVSSRIANPIRLLEKCVKKLENGVKDVDVSISGSYEVQHLGKAIRSMV 368 Query: 367 ASVVQLLDKVRSEQEKKRQIELQAMQAQIQPHFLYNTLSSIKHLIDMNERQRASTMVSAL 426 + L+D + EQE KR+ EL A+QAQI PHFLYNTL SI +I+ A MV+AL Sbjct: 369 NQMHTLMDNIMIEQESKRKSELNALQAQINPHFLYNTLDSIIWMIENENYDGAIIMVTAL 428 Query: 427 TSYFRISISKGREIIPVREEMEHVRSYLMILNIRYSQEFDYEINVADEXXXXXXXXXXXQ 486 FRIS+SKG+ II VR+E+EH R+YL I NIRY +F Y I V ++ Q Sbjct: 429 AKLFRISLSKGKNIITVRDEIEHARNYLTIQNIRYKNKFTYNIEVDEKVLNYGSIKLIIQ 488 Query: 487 PIVENAIYHGIKNKHGQGHLSVTGYREGDNAVFEVYDNGHGISEAKLSQLRASLQSDTAA 546 P++ENAIYHG++ G G + V Y + + +V DNG G+ L + SL + + Sbjct: 489 PLIENAIYHGMEFMGGDGEILVKAYAKDNELYIDVVDNGLGM----LQDVANSLLTGESK 544 Query: 547 YEAIT--YGLWNAHMRIVLHFGSSYGLQLDSEEGVYTRVKVYLPYAN 591 E + GL N + RI L+FG YGL++ SE T V++++P + Sbjct: 545 IEKKSSGIGLKNVNERIQLYFGKRYGLEIYSEPDEGTTVRIHMPCVD 591 Database: pfamseq Posted date: Aug 5, 2010 3:22 PM Number of letters in database: 3,060,696,203 Number of sequences in database: 9,421,015 Lambda K H 0.319 0.135 0.383 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 9421015 Number of Hits to DB: 3,139,169,898 Number of extensions: 118929600 Number of successful extensions: 335255 Number of sequences better than 1.0e-05: 2155 Number of HSP's gapped: 332497 Number of HSP's successfully gapped: 2156 Length of query: 600 Length of database: 3,060,696,203 Length adjustment: 142 Effective length of query: 458 Effective length of database: 1,722,912,073 Effective search space: 789093729434 Effective search space used: 789093729434 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 134 (56.2 bits)