BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0599.0017.p (579 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_244314.1| two-component sensor histidine kinase [Bacillus... 192 2e-47 ref|NP_623881.1| predicted ATPase [Thermoanaerobacter tengcongen... 182 2e-44 ref|NP_388576.1| similar to two-component sensor histidine kinas... 169 2e-40 ref|ZP_00100011.1| COG2972: Predicted signal transduction protei... 154 4e-36 ref|NP_345167.1| sensor histidine kinase, putative [Streptococcu... 154 5e-36 >ref|NP_244314.1| two-component sensor histidine kinase [Bacillus halodurans] pir||G84080 two-component sensor histidine kinase BH3447 [imported] - Bacillus halodurans (strain C-125) dbj|BAB07166.1| two-component sensor histidine kinase [Bacillus halodurans] Length = 602 Score = 192 bits (488), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 138/562 (24%), Positives = 269/562 (47%), Gaps = 39/562 (6%) Query: 39 LSKVIENKMSDTTSNLLGSINWNIQTFVNDVESISKLMLSSRDVQNFLSYTKNDFKEIYD 98 + ++IE ++++ T L+ +N I+ + +V++++ + ++Q FL T D Sbjct: 39 VDRIIEQQVNENTLQLIDKVNSTIEAHIENVQNMTYFISLHSNIQQFLDGTLEHLGP--D 96 Query: 99 LQNATRSLIVNITNNKSYIRYVYVGSGQRELITTNQWDRLTYDNIYQAVSRTTWYQQVGE 158 + + N T I + V + Q + ++ + R +++ +++ +WY+Q E Sbjct: 97 EEYEISKFLQNFTTLYPEIAGILVVNQQGDYLSNELYTRSSFN-----LNQESWYRQAVE 151 Query: 159 MGGRGLWLNSDEVRLLKGSPN-----LLLYGKRLNNLETLEPIGMLIISIDRRVFDEMFK 213 G + + R + + ++ + + + T E G+++I + RV +E + Sbjct: 152 NKGIAKLIGKPQGRRITSHVHYREDEVVTVVRAIIDSTTGEEKGVILIDLKLRVIEEAVR 211 Query: 214 NISNAEKGDLMILEQN-KIIYSNSGNNDLKKVPQKDLNQIYDLPERGNRIETMGGERYVI 272 ++ + G LM+++Q IYS + + ++ +Q Y G E + GERY + Sbjct: 212 DVRLGKSGYLMVVDQKGDPIYSPAPSIMYEQSFDHRFSQNY-----GIFTEEVEGERYQL 266 Query: 273 TFETNPVTQWKVVSMIPYSSINSEIILIRNVTLSLTLVAFLLAAYGAYLISKRITKQLTL 332 ++ + T W ++ + E+ I ++ + +Y +S I++ + Sbjct: 267 MYQQSAFTGWTLIGVFSTDQSVEEVQQILFYVVTFVFFVCFVGITASYFLSYTISRPINQ 326 Query: 333 LTSVARKAAKRDEIEGILFVEEDEIGKIGNQFLRTFRTNTELSDXXXXXXXXXXXXXXXX 392 L +KA D E+DE+G++G F +L Sbjct: 327 LMLAMQKAESGDLTSRYEGEEQDEVGRLGRSFNTMIEQIGKLISLTERQERKKREAELHS 386 Query: 393 XQSQINPHFLYNTLNSIYLMAERISAKNISKMVMSLSNIFKLSLNNGDYITTVGNEIEQV 452 Q+ I PHFLYNTL++I MA + +A +++ +V +LS +F++ L+ G I + +EIE + Sbjct: 387 LQANIKPHFLYNTLDTIQWMARKKNASDVADLVGALSKLFRIGLSKGGTIIPLVDEIEHI 446 Query: 453 KNYLEIQNIRYKGKFEVIIDLEPGIEHIRMLKLLIQPLVENAIFHGIELKEGKGSIVIRG 512 KNYL+IQ++RYK K + + +E + +LK+++QP+VENAI+HGI+ + G G I I Sbjct: 447 KNYLQIQSVRYKNKLNYSLVMPSNMERLSILKIVLQPIVENAIYHGIKERRGPGLITIEA 506 Query: 513 RREGAILIFEVEDDGVGFDPVDMQ---------------------PRGYALRNIQERIQL 551 RE +LI + D+G G P +Q +GY L N+ R++L Sbjct: 507 ERENDMLIIRIRDNGKGIKPETLQQLRTNVNLFLEKGDKEGGQRLTKGYGLINVHARLRL 566 Query: 552 HYGQDRGIRIDSIPGAGTKITL 573 +G+ G++IDS+ GT +T+ Sbjct: 567 TFGEPYGVKIDSVFNEGTVVTI 588 >ref|NP_623881.1| predicted ATPase [Thermoanaerobacter tengcongensis] gb|AAM25485.1| predicted ATPase [Thermoanaerobacter tengcongensis] Length = 593 Score = 182 bits (463), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 152/573 (26%), Positives = 281/573 (49%), Gaps = 38/573 (6%) Query: 28 LVLIASLTFVYLSKVIE-NKMSDTTSNLL----GSINWNIQTFVNDVESISKLMLSSRDV 82 +V+I SL V+ S I N++ N L I +I DV +S ++ + + Sbjct: 25 IVVITSLLIVFFSYTISINQLKKEVGNSLLRDTKRIAASIDFLQRDVNELSSFLVLDQRI 84 Query: 83 QNFLSYTKNDFKEIYDLQNATRSLIVNITNNKSYIRYVYVGSGQ-RELITTNQWDRLTYD 141 QNF+S +DF + Y L + ++ +K YI ++ + S Q + +N L D Sbjct: 85 QNFIS-PHSDFTK-YSL-----GPLASLLASKDYISFIALYSFQGDKYYFSNDSSTLIMD 137 Query: 142 NIYQAVSRTTWYQQVGEMGGRGLWLNSDEVR---LLKGSPNLLLYGKRLNNLETLEPIGM 198 + + RT++Y++V E G +WL+ + + ++K + + + L + T +P G+ Sbjct: 138 --LELIKRTSFYREVLEKNGAPMWLSLENLPFDLIIKNNYPKIAMARVLLDFNTYKPEGL 195 Query: 199 LIISIDRRVFDEMFKNISNAEKGDLMILEQNK--IIYSNSGNNDLKKVPQKDLNQIYDLP 256 L+I I+ ++++ ++ I ++N I + ++ + K Q L + L Sbjct: 196 LVICINIPTIEKVYSENLKEKESAFFIADRNGNIISFKSTFSGFTPKSAQNILAKY--LK 253 Query: 257 ERGNRIETMGGERYVITFETNPVTQWKVVSMIPY-SSINSEIILIRNVTLSLTLVAFLLA 315 ++ N + + + ++T P + W++VS++ ++INS I L + + L A Sbjct: 254 DKQNVVININSSKLLVTSSPIPTSDWRLVSVVSLKNAINSIRISFIEFYLRILVFCLLFA 313 Query: 316 AYGAYLISKRITKQLTLLTSVARKAAKRDEIEGILF--VEEDEIGKIGNQFLRTFRTNTE 373 + S+ +T L L + +K + + E + F +DEI + ++ R + Sbjct: 314 FLVSMYFSRALTHPLERLANSMKKVRQGNLEEKVEFEYHSKDEIAIVIKEYNRMVERIND 373 Query: 374 LSDXXXXXXXXXXXXXXXXXQSQINPHFLYNTLNSIYLMAERISAKNISKMVMSLSNIFK 433 L + ++QINPHFLYNTL++I+ AE+ + +S+M+ SLS +F+ Sbjct: 374 LINRILKLEINKREAELKALEAQINPHFLYNTLDTIFWKAEKAKDRELSEMIYSLSRLFR 433 Query: 434 LSLNNGDYITTVGNEIEQVKNYLEIQNIRYKGKFEVIIDLEPGIEHIRMLKLLIQPLVEN 493 L+LN G+ V E E ++ YL +Q+ RYK KF+ + + I + KL++QP VEN Sbjct: 434 LTLNRGEEFIQVRGEKELIERYLFLQSKRYKNKFKYSVKISDEILDYYIPKLILQPFVEN 493 Query: 494 AIFHGIELKEGKGSIVIRGRREGAILIFEVEDDGVGFDPVDMQPR-------------GY 540 AI HG+E + + + G +EG L F ++D+G G ++ GY Sbjct: 494 AIVHGLENNSEESFVEVIGEKEGENLKFIIKDNGPGMSEETLEKLKRFIESENIEEKVGY 553 Query: 541 ALRNIQERIQLHYGQDRGIRIDSIPGAGTKITL 573 A+RN+ ER++L+YG ++I+S G GT I+L Sbjct: 554 AIRNVNERLRLYYGDKYELKIESRQGEGTTISL 586 >ref|NP_388576.1| similar to two-component sensor histidine kinase [YesN] [Bacillus subtilis] pir||D69796 two-component sensor histidine kinase homolog yesM - Bacillus subtilis emb|CAB12514.1| yesM [Bacillus subtilis subsp. subtilis str. 168] Length = 577 Score = 169 bits (428), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 141/572 (24%), Positives = 274/572 (47%), Gaps = 43/572 (7%) Query: 25 LLPLVLIASLTFVYLS-----KVIENKMSDTTSNLLGSINWNIQTFVNDVESISKLMLSS 79 L L++ S FVY V + ++ +S +L + I+ + +E +S +++ Sbjct: 21 FLSLIMAVSFLFVYSGVQYAFHVYDEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITD 80 Query: 80 RDVQNFLSY-TKNDFKEIYDLQNATRSLIVNITNNKSYIRYVYV--GSGQRELITTNQWD 136 +Q LS ++D + Y ++ + +++ YI ++V G ++ D Sbjct: 81 EQIQRILSMQNRDDTYDQYQMKQELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSD 140 Query: 137 RLTYDNIYQAVSRTTWYQQVGEMGGRGLWLNSDEVRLLKGSPNLLLYGKRLNNLE--TLE 194 L + + +++ GR LW+ L GS +L+ +++ + +L Sbjct: 141 LLQQE-------QEEVFKRAKAKSGRNLWMT------LGGSDPVLISARQIRSYHQLSLN 187 Query: 195 PIGMLIISID-RRVFDEMFKNISNAEKGDLMILEQN-KIIYSNSGNNDLKKVPQKDLNQI 252 +GM++I ++ +++ ++ K+ ++ GD+MI +Q ++Y+ + + + ++ L Sbjct: 188 GLGMVLIQVNVKQMIRDVPKDWGDS-VGDIMIADQGGNLVYTAHASAHVPEAAKETLKHP 246 Query: 253 -YDLPERGNRIETMGGERYVITFETNPVTQWKVVSMIPYSSINSEIILIRNVTLSLTLVA 311 YDL ++ G+RY I++ + W ++IP+ + ++I ++ V + L+ Sbjct: 247 GYDLIKKN-------GKRYFISYLQSSYQNWSYYNVIPFDQMFAKISFMKTVIGTCFLLF 299 Query: 312 FLLAAYGAYLISKRITKQLTLLTSVARKAAKRDEIEGILFVE-----EDEIGKIGNQFLR 366 F + I+ IT+ + L + A K+ + IE + + +DE G + F Sbjct: 300 FCVVLLFGRKIANSITEPIEQLVT-AMKSVQHSGIEAGVSLSLPEHTQDEAGMLNRHFTV 358 Query: 367 TFRTNTELSDXXXXXXXXXXXXXXXXXQSQINPHFLYNTLNSIYLMAERISAKNISKMVM 426 + EL + Q+QINPHFLYNTL SI +A+ K ISKMV Sbjct: 359 MMKRINELMEENVEKQLIIKETELKALQAQINPHFLYNTLESINWLAKANQQKQISKMVE 418 Query: 427 SLSNIFKLSLNNGDYITTVGNEIEQVKNYLEIQNIRYKGKFEVIIDLEPGIEHIRMLKLL 486 SL + + S++ I T+ E + V++Y+ IQ R++ + + +D++ ++H + KL Sbjct: 419 SLGFLLRNSIHMKKDIVTIQEEADIVRHYMTIQRFRFEERLKFTLDIDDEVKHCLIPKLT 478 Query: 487 IQPLVENAIFHGIELKEGKGSIVIRGRREGAILIFEVEDDGVGFDPVDMQP---RGYALR 543 +QPL ENAI + +E +I I+ ++ + VED+G G D ++ RG L Sbjct: 479 LQPLAENAIQYALEPFTRPCAIRIQAKKAKGCVCITVEDNGPGMDGRILESTGGRGIGLW 538 Query: 544 NIQERIQLHYGQDRGIRIDSIPGAGTKITLEI 575 NI+ERI L +G+ G+RI S GT+I + I Sbjct: 539 NIRERISLTFGEPYGLRIHSEHEKGTRIVITI 570 >ref|ZP_00100011.1| COG2972: Predicted signal transduction protein with a C-terminal ATPase domain [Desulfitobacterium hafniense] Length = 577 Score = 154 bits (390), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 145/575 (25%), Positives = 260/575 (45%), Gaps = 45/575 (7%) Query: 22 ACSLLPLVLIASLTFVYLSKVIENKMSDTTSNLLGSINWNIQTFVNDVESISKLMLSSRD 81 A +L + + F ++++ +++ TT+ + ++ +++ ++ +S L+ S Sbjct: 20 AATLFIVGAMGLALFFSTTRIVSQEVAKTTATAIDKSGRQLEMYIDQLKGLSDLLAESPQ 79 Query: 82 VQNFLSYTKNDFKEIYDLQNATRSLIVNITNNKSYIRYVYVGSGQRELITTNQWDRLTYD 141 V + + D D + +I + N I + + + +LIT Q + Y Sbjct: 80 VHRYFDQSGPD-DVAGDERRDIERMIQGMLNTNPEIASIILIGAKGQLITNEQNLEMHYS 138 Query: 142 NIYQAVSRTTWYQQVGEMGGRGLWLNSDEVRLLKGSPN--LLLYGKRLNNLETLEPIGML 199 + WYQ+ +G L S ++ + ++ G+ L + E + +G+L Sbjct: 139 G---DIQDQEWYQEA--LGSTMPILTSARMQEFSMDKDNWVISLGRELTD-EKKKHLGVL 192 Query: 200 IISIDRRVFDEMFKNISNAEKGDLMILEQNK-IIYSNSGNN-----------DLKKVPQK 247 I + + + K++S ++G IL Q++ ++Y + D+ ++ K Sbjct: 193 RIDLKYDAIESILKDMSLGQEGYSYILNQSQQVVYHPNPQYFSQEEKRLELIDMLEMEGK 252 Query: 248 DLNQIYDLPERGNRIETMGGERYVITFETNPVTQWKVVSMIPYSSINSEIILIRNVTLSL 307 +L++ Y L R N + +V+ V S+ + +EII + L + Sbjct: 253 ELSREYKLTHRYN----LNNSDWVLV---------GVASLDGVRRMEAEII----IVLVV 295 Query: 308 TLVAFLLAAYGAYLI-SKRITKQLTLLTSVARKAAKRDEIEGILFVEEDEIGKIGNQFLR 366 LLAA+G+ I + + + + L + K + V EI + FL Sbjct: 296 LGSVLLLAAFGSSAIYASSVARPIRQLEKAMEEVEKGSLATEVGVVGSAEIASLSTHFLS 355 Query: 367 TFRTNTELSDXXXXXXXXXXXXXXXXXQSQINPHFLYNTLNSIYLMAERISAKNISKMVM 426 EL SQINPHFLYNTL++I +AE + + + + Sbjct: 356 MLDRIRELMQEIRNKEQFLRASELKTLYSQINPHFLYNTLDTIVWLAEFGNTERVITVSK 415 Query: 427 SLSNIFKLSLNNGDYITTVGNEIEQVKNYLEIQNIRYKGKFEVIIDLEPGIEHIRMLKLL 486 +++ F+LSL G TTV +E++ V+ YL IQ RY+ K I E G+ I + K+L Sbjct: 416 AMARFFRLSLRGGSETTTVRDELDHVRQYLFIQKERYQDKLSYEIQAEDGLMDITIPKIL 475 Query: 487 IQPLVENAIFHGIELKEGKGSIVIRGRR-EGAILIFEVEDDGVGFDPVD-----MQPRGY 540 +QPLVENAI+HG+ G G I I R+ E L VED+G GF+ + ++ G Sbjct: 476 LQPLVENAIYHGLRKMPGGGMIRITARKGEKEDLFLVVEDNGGGFEDAEKGKDPLRLGGV 535 Query: 541 ALRNIQERIQLHYGQDRGIRIDSIPGAGTKITLEI 575 L+N+ ERI+L+YG+D G+ I + PG G I L + Sbjct: 536 GLKNVAERIRLYYGEDYGLSIANRPGQGATIILRL 570 >ref|NP_345167.1| sensor histidine kinase, putative [Streptococcus pneumoniae TIGR4] pir||F95076 sensor histidine kinase, probable [imported] - Streptococcus pneumoniae (strain TIGR4) emb|CAB54581.1| histidine kinase [Streptococcus pneumoniae] gb|AAF31453.1| putative histidine kinase [Streptococcus pneumoniae] gb|AAK74807.1| sensor histidine kinase, putative [Streptococcus pneumoniae TIGR4] Length = 563 Score = 154 bits (389), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 150/577 (25%), Positives = 262/577 (45%), Gaps = 64/577 (11%) Query: 25 LLPLVLIASLTFVYLSKVIENKMSDTTSNLLGSINWNIQTFVNDVESISKLMLSSRDVQN 84 L+ L L+ + + S IE + + + + IQ+++ +E+ S + DV Sbjct: 19 LILLALVGTFYYQSSSSAIEATIEGNSQTTISQTSHFIQSYIKKLETTSTGLTQQTDV-- 76 Query: 85 FLSYTKNDFKEIYDLQNATRSLIVNITNNKSYIRYVYVGSGQRELITTNQWDRLTYDNIY 144 L+Y +N + D R L + I + ++ V + + ++I+T+ ++ + Sbjct: 77 -LAYAENPSQ---DKVEGIRDLFLTILKSDKDLKTVVLVTKSGQVISTDDSVQMKTSSDM 132 Query: 145 QAVSRTTWYQQVGEMGGRGLWL---NSDEVRLLKGSPNLLLYGKRLNNLETLEPIGMLII 201 A WYQ+ G + SD ++ + L+ K N +G+L + Sbjct: 133 MA---EDWYQKAIHQGAMPVLTPARKSDSQWVISVTQELV-DAKGAN-------LGVLRL 181 Query: 202 SIDRRVFDEMFKNISNAEKGDLMILEQNK--------IIYSNSGNNDLKKVPQKDLNQIY 253 I + + ++G I+ +N +YS+S + K P D Q Y Sbjct: 182 DISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQHTVYSSSSKMEAMK-PYIDTGQGY 240 Query: 254 DLPERGNRIETMGGERYVITFETNPVTQWKVV---SMIPYSSINSEIIL------IRNVT 304 T G + YV + E T W V+ S+ + S+++ + ++ Sbjct: 241 ----------TPGHKSYV-SQEKIAGTDWTVLGVSSLEKLDQVRSQLLWTLLGASVTSLL 289 Query: 305 LSLTLVAFLLAAYGAYLISKRITKQLTLLTSVARKAAKRDEIEGILFVEEDEIGKIGNQF 364 + L LV F L + A L R T L + + AK V E+ ++ QF Sbjct: 290 VCLCLVWFSLKRWIAPLKDLRET-MLEIASGAQNLRAKE--------VGAYELREVTRQF 340 Query: 365 LRTFRTNTELSDXXXXXXXXXXXXXXXXXQSQINPHFLYNTLNSIYLMAERISAKNISKM 424 +L SQINPHFLYNTL++I MAE ++ + ++ Sbjct: 341 NAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFHDSQRVVQV 400 Query: 425 VMSLSNIFKLSLNNGDYITTVGNEIEQVKNYLEIQNIRYKGKFEVIIDLEPGIEHIRMLK 484 SL+ F+L+LN G + + +EI V+ YL IQ RY K E I+ +++ + K Sbjct: 401 TKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINENVAFDNLVLPK 460 Query: 485 LLIQPLVENAIFHGIELKEGKGSIVIRGRREGAILIFEVEDDGVGF-DPVD-----MQPR 538 L++QPLVENA++HGI+ KEG+G I + +++ + L+ +EDDGVGF D D ++ Sbjct: 461 LVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQDAGDSSQSQLKRG 520 Query: 539 GYALRNIQERIQLHYGQDRGIRIDSIPGAGTKITLEI 575 G L+N+ +R++LH+G + ++IDS P GTK+ + I Sbjct: 521 GVGLQNVDQRLKLHFGANYHMKIDSRPQKGTKVEIYI 557 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.319 0.138 0.385 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 767,771,242 Number of extensions: 32187004 Number of successful extensions: 103300 Number of sequences better than 1.0e-05: 195 Number of HSP's gapped: 103106 Number of HSP's successfully gapped: 195 Length of query: 579 Length of database: 757,237,578 Length adjustment: 131 Effective length of query: 448 Effective length of database: 401,559,609 Effective search space: 179898704832 Effective search space used: 179898704832 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 129 (54.3 bits)