BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0591.0029.p (453 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|ZP_00130102.1| COG2233: Xanthine/uracil permeases [Desulfovi... 222 1e-56 ref|NP_987801.1| Xanthine/uracil permease family [Methanococcus ... 188 3e-46 ref|NP_578969.1| putative purine permease [Pyrococcus furiosus D... 186 1e-45 ref|NP_126472.1| uracil/xanthine permease [Pyrococcus abyssi] >g... 182 1e-44 ref|NP_816078.1| xanthine/uracil permease family protein [Entero... 178 3e-43 >ref|ZP_00130102.1| COG2233: Xanthine/uracil permeases [Desulfovibrio desulfuricans G20] Length = 435 Score = 222 bits (566), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 137/417 (32%), Positives = 228/417 (54%), Gaps = 11/417 (2%) Query: 4 THSEEQVLTVGIEEKLSIGANVTYGFQHLLALTGIFLFPVLIGQALGLDASIIGYMIQAC 63 + + E LTVG++E +S G QH+LA+ +++ P ++ L L IQ Sbjct: 2 SRNTELHLTVGVDEPVSPLKAFALGLQHVLAMD-VYIAPFVMAGLLSLSVPETATFIQMT 60 Query: 64 FLTTGIVTVLQSGKMLRLPVVQGPTAAFFVAVLSAGSTVGLGTAFGSMAVAGLIFMLLSI 123 F+ G+ T++Q+G +RLPV+QGP+ A+ + G+++GLG FGS+ L+ LL Sbjct: 61 FVAAGLATLIQAGFGIRLPVMQGPSYVPIGALAAIGNSLGLGAMFGSLLPGALVMTLLGK 120 Query: 124 PVRRFGLIGYLNKFISPPIVYGTLLIIIGAQLADIGLKNWFGS-ADTGINFAASXXXXXX 182 P+R F I +F PP+V GT+++I+G L + LK +G D N + Sbjct: 121 PLRVFSRI---VRFFIPPLVGGTVIVIVGIALMPVALKGCYGYFGDPAHNAVVALVSAAV 177 Query: 183 XXXXXXFGG-----NTILRRGALLWGIIAGTIFYSIFGTTNFSSVAAAGWFSFPDVFPFG 237 G N ++R G++++ + AGT+ + FG NF SVAAA W + P +FP+G Sbjct: 178 LVVLTVAGSRPGRFNQVVRMGSVVFSMAAGTLTAAAFGMVNFDSVAAAPWLALPVIFPYG 237 Query: 238 F-GVSVPIVILMLLAFLQASAEAVGMYTLLTKWGNQKLDNDRVNRGLFGEFLGSTLGAVF 296 + V + ++ +L E G + + +LD++R+N G FGE +G LGA+ Sbjct: 238 TPHIDVSAALTLVFIYLVVLVETTGTWFAVEAVTGSRLDDERINGGTFGEGVGCFLGAML 297 Query: 297 GGLGTTSYPENIGIVRVSGIGSRYVTMTAGVLAIVLGLIPKVGMFIASLPGPVLSAASTI 356 GG T Y N GI+ ++G+ SR+ M G + +VLG++PK+ IAS+PGPV+S + Sbjct: 298 GGTPVTGYSTNAGIIAITGVASRWAIMAGGGILLVLGMVPKLMNVIASIPGPVISGVFAV 357 Query: 357 LFGIIAISGIQMVSKVVWDELNLVVAGSSFIISLGTMYLPAELTQNLPLAFQSIVTQ 413 + +IA++G ++V V E N++V G +++L +++PAEL LP + +V Sbjct: 358 ICVVIAMNGFRVVRTVTLSERNMLVMGLPILLTLAAVFMPAELRDRLPALVRYLVES 414 >ref|NP_987801.1| Xanthine/uracil permease family [Methanococcus maripaludis S2] emb|CAF30237.1| Xanthine/uracil permease family [Methanococcus maripaludis] Length = 413 Score = 188 bits (477), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 131/401 (32%), Positives = 216/401 (53%), Gaps = 15/401 (3%) Query: 24 NVTYGFQHLLALTGIFL-FPVLIGQALGLDASIIGYMIQACFLTTGIVTVLQSGKMLRLP 82 + GFQH+LA+ G + P+++G A+GL S I ++QA L G+ T+LQ+ R P Sbjct: 3 RIALGFQHVLAMFGATVTVPLVVGYAIGLSMSEIALLLQAVLLAMGVATLLQTFAGSRFP 62 Query: 83 VVQGPTAAFFVAVLSAGSTVGLGTAFGSMAVAGLIFMLLSIPVRRFGLIGYLNKFISPPI 142 +VQG + AF +++ GS +GL G++ + G+I + GLIG L K SP I Sbjct: 63 IVQGSSFAFIPGLIAVGSGMGLAAVEGALIIGGVIEAI----TGALGLIGKLKKLFSP-I 117 Query: 143 VYGTLLIIIGAQLADIGLK---NWFGSADTGINFAASXXXXXXX---XXXXXFGGNTILR 196 V G +++IG LAD+ ++ N+F TG + S G L+ Sbjct: 118 VTGVTIMLIGFSLADVAVQYSFNYFAD-PTGSSIVTSILVAALTFITTILVSLQGKGTLK 176 Query: 197 RGALLWGIIAGTIFYSIFGTTNFSSVAAAGWFSFPDVFPFGFGV-SVPIVILMLLAFLQA 255 ++ G + G + G +FS + WF+ P + P+G V V +I++L AF+ + Sbjct: 177 AMPVIIGAVVGYVISIFLGLVDFSMMNQLSWFALPKLMPWGMPVFDVNAIIILLFAFMVS 236 Query: 256 SAEAVGMYTLLTKWGNQKLDNDRVNRGLFGEFLGSTLGAVFGGLGTTSYPENIGIVRVSG 315 E+VG Y ++ + K+D++++NRG+ E TL +FG GTTSY ENIG+V ++ Sbjct: 237 IIESVGDYHAISTIADLKIDDNKINRGIASEGFSCTLAGLFGACGTTSYSENIGLVALTK 296 Query: 316 IGSRYVTMTAGVLAIVLGLIPKVGMFIASLPGPVLSAASTILFGIIAISGIQMV-SKVVW 374 + S V V+ ++L +IPK +AS+P PVL +T L+G+I+I+G++++ KV Sbjct: 297 VSSVQVVQIGAVILVLLSMIPKFSGLLASIPAPVLGGLTTALYGMISITGLKLIKDKVEL 356 Query: 375 DELNLVVAGSSFIISLGTMYLPAELTQNLPLAFQSIVTQPM 415 ++ N ++ S+ ++ LG LPAE P SI+ M Sbjct: 357 NDRNTLILASALVLGLGAPQLPAEFLSLFPKIISSILESGM 397 >ref|NP_578969.1| putative purine permease [Pyrococcus furiosus DSM 3638] gb|AAL81364.1| putative purine permease [Pyrococcus furiosus DSM 3638] Length = 427 Score = 186 bits (471), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 127/413 (30%), Positives = 214/413 (51%), Gaps = 13/413 (3%) Query: 11 LTVGIEEKLSIGANVTYGFQHLLALTGIFL-FPVLIGQALGLDASIIGYMIQACFLTTGI 69 + V I+EK+ + +G QH+LA+ G + P+++G +GL I MIQA L GI Sbjct: 5 IKVKIDEKVEPKRAILFGLQHVLAMFGATVTVPLVVGTTVGLSTREIATMIQAVLLAMGI 64 Query: 70 VTVLQSGKMLRLPVVQGPTAAFFVAVLSAGSTVGLGTAFGSMAVAGLIFMLLSIPVRRFG 129 T+LQ+ R P+VQG + AF ++S G ++G+ G++ V G+I L V G Sbjct: 65 ATILQTTIGSRYPIVQGSSFAFIPGLISIGKSLGMAATQGALIVGGIIEAL----VGGLG 120 Query: 130 LIGYLNKFISPPIVYGTLLIIIGAQLADIGLKNWFGS-AD-TGINFAASXXXXXXXXXXX 187 ++G + K +P +V G +++IG LA + +K +F AD +G + + Sbjct: 121 IVGKIKKLFTP-VVTGVTIMLIGFSLAHVSVKYFFNYFADPSGASIPRATIVALITFGTT 179 Query: 188 XF---GGNTILRRGALLWGIIAGTIFYSIFGTTNFSSVAAAGWFSFPDVFPFGFGV-SVP 243 + LR ++ G G + G +F V S P +FP+G V V Sbjct: 180 VYVALKSRGTLRAMPVIVGAFVGYLVSIPLGLADFQLVKELPVVSVPKIFPWGTPVFDVG 239 Query: 244 IVILMLLAFLQASAEAVGMYTLLTKWGNQKLDNDRVNRGLFGEFLGSTLGAVFGGLGTTS 303 +I +L AF+ + E+VG Y ++ + N +NRG+ E + ++ V G GTTS Sbjct: 240 AIITLLFAFMVSIIESVGDYHAISAIAEAPITNKHINRGIMSEGIACSIAGVLGACGTTS 299 Query: 304 YPENIGIVRVSGIGSRYVTMTAGVLAIVLGLIPKVGMFIASLPGPVLSAASTILFGIIAI 363 Y ENIG+V ++ + SRYV G++ IV+ L PK +A++P PVL + L+G+I++ Sbjct: 300 YSENIGLVALTKVASRYVVQVGGIILIVISLFPKFAGLLAAMPAPVLGGLTLALYGMISV 359 Query: 364 SGIQMV-SKVVWDELNLVVAGSSFIISLGTMYLPAELTQNLPLAFQSIVTQPM 415 +G++++ KV ++ N ++ ++ I LG LP E ++ P SI+ M Sbjct: 360 TGLRLIKEKVELNDRNTIIIATALIAGLGAPQLPPEFLEHFPQIIASILESGM 412 >ref|NP_126472.1| uracil/xanthine permease [Pyrococcus abyssi] pir||F75123 uracil/xanthine permease PAB1838 - Pyrococcus abyssi (strain Orsay) emb|CAB49703.1| Uracil/xanthine permease [Pyrococcus abyssi] Length = 427 Score = 182 bits (462), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 121/411 (29%), Positives = 213/411 (51%), Gaps = 13/411 (3%) Query: 13 VGIEEKLSIGANVTYGFQHLLALTGIFL-FPVLIGQALGLDASIIGYMIQACFLTTGIVT 71 V ++EK+ + G QH+LA+ G + P+++G A+GL I MIQA L GI T Sbjct: 7 VKVDEKVEPRKAILLGLQHVLAMFGATVTVPLVVGTAVGLSKEEISIMIQAVLLAMGIAT 66 Query: 72 VLQSGKMLRLPVVQGPTAAFFVAVLSAGSTVGLGTAFGSMAVAGLIFMLLSIPVRRFGLI 131 +LQ+ R P+VQG + AF ++S G ++G+ G++ V G+I L+ G++ Sbjct: 67 LLQTTIGSRYPIVQGSSFAFIPGLISIGKSLGMAATEGALIVGGIIEALIG----GTGIV 122 Query: 132 GYLNKFISPPIVYGTLLIIIGAQLADIGLKNWFG--SADTGINFAASXXXXXXXXXXXXF 189 G + + +P +V G +++IG LAD+ +K +F + +G + + + Sbjct: 123 GKVKRLFTP-LVTGVTIMLIGFSLADVAVKYFFNFYADPSGSSIPRATIVALVTFITTVY 181 Query: 190 ---GGNTILRRGALLWGIIAGTIFYSIFGTTNFSSVAAAGWFSFPDVFPFGF-GVSVPIV 245 +R ++ G + G + G NF V S P FP+G ++ + Sbjct: 182 VALKAKGPIRAMPVIAGALVGYLVSVPLGLANFQLVKELPLVSLPRPFPWGIPEFNLTAI 241 Query: 246 ILMLLAFLQASAEAVGMYTLLTKWGNQKLDNDRVNRGLFGEFLGSTLGAVFGGLGTTSYP 305 + +L AF+ + E+VG Y ++ + N +NRG+ E + ++ + G GTTSY Sbjct: 242 VTLLFAFMVSIIESVGDYHAISAIAEAPITNKHINRGIMSEGIACSIAGILGACGTTSYS 301 Query: 306 ENIGIVRVSGIGSRYVTMTAGVLAIVLGLIPKVGMFIASLPGPVLSAASTILFGIIAISG 365 ENIG+V ++ + SRYV G++ +VL L PK +AS+P PVL + L+G+I+++G Sbjct: 302 ENIGLVALTKVASRYVVQIGGIILVVLSLFPKFAGILASMPAPVLGGLTIALYGMISVTG 361 Query: 366 IQMV-SKVVWDELNLVVAGSSFIISLGTMYLPAELTQNLPLAFQSIVTQPM 415 ++++ KV ++ N ++ +S I+ LG LP + + P SI+ M Sbjct: 362 LRLIKDKVELNDRNTLILATSLIVGLGAPQLPPKFLAHFPRIVASILESGM 412 >ref|NP_816078.1| xanthine/uracil permease family protein [Enterococcus faecalis V583] gb|AAO82148.1| xanthine/uracil permease family protein [Enterococcus faecalis V583] Length = 443 Score = 178 bits (451), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 126/435 (28%), Positives = 213/435 (48%), Gaps = 32/435 (7%) Query: 1 MHSTHSEEQVLTVGIEEKLSIGANVTYGFQHLLALTGIFLFPVLIGQALGLDASIIGYMI 60 M LTVG E+ +S G G QH+LA+ +++ PV+I +G+ + +I Sbjct: 1 MSEKKQNNLHLTVGPEDSVSFGQATMLGIQHVLAMD-VYVVPVIIASIIGISTAQTSSLI 59 Query: 61 QACFLTTGIVTVLQSGKMLRLPVVQGPT-------AAFFVAVLSAGSTVGLGTAFGSMAV 113 QA F+ G+ T++QS +RLPV QGP+ A + A G+ G G G+ V Sbjct: 60 QATFIAAGLATIIQSHFCMRLPVAQGPSFIPIGAIAGIYFANNQQGN--GWGAVLGASLV 117 Query: 114 AGLIFMLLSIPVRRFGLIGYLNKFIS---PPIVYGTLLIIIGAQLADIGLKN--WFGSAD 168 ++ ++L G G N+ I+ PPIV GT++ ++G L + L + + + Sbjct: 118 GAIVVIIL-------GFTGIFNRLITKFVPPIVGGTIIFVVGLSLMPVALSDNIYHAKGE 170 Query: 169 TGIN----FAASXXXXXXXXXXXXFGGNTILRRGALLWGIIAGTIFYSIFGTTNFSSVAA 224 G N F A+ I R +++ ++ G+I + G + S+V+ Sbjct: 171 LGQNILLAFIAAGTLIFFALLGSALKKGRIFRVSSVILALLFGSIAAQLLGVLDLSAVSK 230 Query: 225 AGWFSFPDV----FPFGFGVSVPIVILMLLAFLQASAEAVGMYTLLTKWGNQKLDNDRVN 280 A WFS P + F F F S + ML+ +L AE G + ++ + L +++N Sbjct: 231 AAWFSLPQLPLVNFSFQFDWSA--IATMLVIYLVLMAETTGTWFAVSHVVAEPLTEEKIN 288 Query: 281 RGLFGEFLGSTLGAVFGGLGTTSYPENIGIVRVSGIGSRYVTMTAGVLAIVLGLIPKVGM 340 RG+ GE LG + + GG TSY N GI+ ++G+ SR V + AG ++ GL K+ Sbjct: 289 RGVIGEGLGCLVSSFIGGTPVTSYSTNAGIISITGVASRKVFVAAGAWFVLFGLSGKLST 348 Query: 341 FIASLPGPVLSAASTILFGIIAISGIQMVSKVVWDELNLVVAGSSFIISLGTMYLPAELT 400 I+++P PV+ ++ GII++SG++++S V E + V I++L LP E Sbjct: 349 LISAIPAPVIGGVFVVVCGIISVSGMKVMSDVTIHEKEMYVIAVPIIMTLALTLLPKEFL 408 Query: 401 QNLPLAFQSIVTQPM 415 + LP Q + + P+ Sbjct: 409 ETLPQFLQYLFSSPV 423 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.325 0.141 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 583,430,365 Number of extensions: 23943028 Number of successful extensions: 93568 Number of sequences better than 1.0e-05: 432 Number of HSP's gapped: 92789 Number of HSP's successfully gapped: 439 Length of query: 453 Length of database: 757,237,578 Length adjustment: 129 Effective length of query: 324 Effective length of database: 406,989,807 Effective search space: 131864697468 Effective search space used: 131864697468 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 128 (53.9 bits)